WO2001041736A3 - Microchip devices for delivery of molecules and methods of fabrication thereof - Google Patents

Microchip devices for delivery of molecules and methods of fabrication thereof Download PDF

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Publication number
WO2001041736A3
WO2001041736A3 PCT/US2000/042478 US0042478W WO0141736A3 WO 2001041736 A3 WO2001041736 A3 WO 2001041736A3 US 0042478 W US0042478 W US 0042478W WO 0141736 A3 WO0141736 A3 WO 0141736A3
Authority
WO
WIPO (PCT)
Prior art keywords
molecules
substrate
reservoirs
devices
methods
Prior art date
Application number
PCT/US2000/042478
Other languages
French (fr)
Other versions
WO2001041736A2 (en
Inventor
Amy C Richards
John T Santini
Michael J Cima
Robert S Langer
Original Assignee
Massachusetts Inst Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Inst Technology filed Critical Massachusetts Inst Technology
Priority to AU45131/01A priority Critical patent/AU782639B2/en
Priority to CA2393603A priority patent/CA2393603C/en
Priority to JP2001542904A priority patent/JP2003516343A/en
Priority to EP00992588A priority patent/EP1235560B1/en
Priority to DE60027458T priority patent/DE60027458T2/en
Publication of WO2001041736A2 publication Critical patent/WO2001041736A2/en
Publication of WO2001041736A3 publication Critical patent/WO2001041736A3/en
Priority to AU2005234663A priority patent/AU2005234663B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0097—Micromachined devices; Microelectromechanical systems [MEMS]; Devices obtained by lithographic treatment of silicon; Devices comprising chips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation

Abstract

Methods of manufacturing microchip devices are provided for controlled release of molecules, such as drugs. Methods include compression molding and casting, alone or in combination with microfabrication techniques. In preferred embodiments, devices are made by (1) filling a die with a polymer powder; (2) compressing the powder to form a polymer preform; (3) thermal compression molding the preform to form a substrate in a mold having a plurality of protrusions that form reservoirs in the substrate; and (4) filling the reservoirs with a release system comprising the molecules to be released. Alternatively, ceramic devices are formed by casting the substrate from a ceramic powder or a slurry using a mold having protrusions that form reservoirs in the substrate. Control over the release rate and time of the molecules from the reservoirs of the microchip device is provided by incorporating release systems and/or reservoir caps.
PCT/US2000/042478 1999-12-10 2000-12-01 Microchip devices for delivery of molecules and methods of fabrication thereof WO2001041736A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
AU45131/01A AU782639B2 (en) 1999-12-10 2000-12-01 Microchip devices for delivery of molecules and methods of fabrication thereof
CA2393603A CA2393603C (en) 1999-12-10 2000-12-01 Microchip devices for delivery of molecules and methods of fabrication thereof
JP2001542904A JP2003516343A (en) 1999-12-10 2000-12-01 Microchip device for delivering molecules and method of making the same
EP00992588A EP1235560B1 (en) 1999-12-10 2000-12-01 Microchip devices for delivery of molecules and methods of fabrication thereof
DE60027458T DE60027458T2 (en) 1999-12-10 2000-12-01 MICROCHIP DRUG DISABLING SYSTEMS AND MANUFACTURING METHOD
AU2005234663A AU2005234663B2 (en) 1999-12-10 2005-11-18 Microchip devices for delivery of molecules and methods of fabrication thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17021899P 1999-12-10 1999-12-10
US60/170,218 1999-12-10

Publications (2)

Publication Number Publication Date
WO2001041736A2 WO2001041736A2 (en) 2001-06-14
WO2001041736A3 true WO2001041736A3 (en) 2002-01-31

Family

ID=22619035

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/042478 WO2001041736A2 (en) 1999-12-10 2000-12-01 Microchip devices for delivery of molecules and methods of fabrication thereof

Country Status (8)

Country Link
US (3) US6808522B2 (en)
EP (1) EP1235560B1 (en)
JP (1) JP2003516343A (en)
AT (1) ATE323470T1 (en)
AU (2) AU782639B2 (en)
CA (1) CA2393603C (en)
DE (1) DE60027458T2 (en)
WO (1) WO2001041736A2 (en)

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