WO2001044307A3 - Degradable poly(vinyl alcohol) hydrogels - Google Patents

Degradable poly(vinyl alcohol) hydrogels Download PDF

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Publication number
WO2001044307A3
WO2001044307A3 PCT/US2000/042190 US0042190W WO0144307A3 WO 2001044307 A3 WO2001044307 A3 WO 2001044307A3 US 0042190 W US0042190 W US 0042190W WO 0144307 A3 WO0144307 A3 WO 0144307A3
Authority
WO
WIPO (PCT)
Prior art keywords
hydrogels
vinyl alcohol
biodegradable
degradable poly
prepolymers
Prior art date
Application number
PCT/US2000/042190
Other languages
French (fr)
Other versions
WO2001044307A2 (en
Inventor
Thomas Hirt
Troy Holland
Vimala Francis
Hassan Chaouk
Original Assignee
Biocure Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocure Inc filed Critical Biocure Inc
Priority to EP00993007A priority Critical patent/EP1250361A2/en
Priority to AU49029/01A priority patent/AU4902901A/en
Priority to CA002391618A priority patent/CA2391618A1/en
Priority to JP2001544794A priority patent/JP2003516810A/en
Publication of WO2001044307A2 publication Critical patent/WO2001044307A2/en
Publication of WO2001044307A3 publication Critical patent/WO2001044307A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F283/00—Macromolecular compounds obtained by polymerising monomers on to polymers provided for in subclass C08G
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/24—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/64—Use of materials characterised by their function or physical properties specially adapted to be resorbable inside the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/048—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/145—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/148—Materials at least partially resorbable by the body
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F261/00—Macromolecular compounds obtained by polymerising monomers on to polymers of oxygen-containing monomers as defined in group C08F16/00
    • C08F261/02—Macromolecular compounds obtained by polymerising monomers on to polymers of oxygen-containing monomers as defined in group C08F16/00 on to polymers of unsaturated alcohols
    • C08F261/04—Macromolecular compounds obtained by polymerising monomers on to polymers of oxygen-containing monomers as defined in group C08F16/00 on to polymers of unsaturated alcohols on to polymers of vinyl alcohol
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/12—Hydrolysis
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L51/00—Compositions of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers
    • C08L51/003—Compositions of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers grafted on to macromolecular compounds obtained by reactions only involving unsaturated carbon-to-carbon bonds

Abstract

Biodegradable biocompatible hydrogels based on poly(vinyl alcohol) and methods for their preparation. The methods for preparation of the hydrogels involve the use of prepolymers. The prepolymers have a PVA backbone and pendant chains that include a polymerizable group. In one embodiment, the pendant chains also include a biodegradable region. In another embodiment, biodegradable regions are incorporated into the hydrogel during formation.
PCT/US2000/042190 1999-11-15 2000-11-15 Degradable poly(vinyl alcohol) hydrogels WO2001044307A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP00993007A EP1250361A2 (en) 1999-11-15 2000-11-15 Degradable poly(vinyl alcohol) hydrogels
AU49029/01A AU4902901A (en) 1999-11-15 2000-11-15 Degradable poly(vinyl alcohol) hydrogels
CA002391618A CA2391618A1 (en) 1999-11-15 2000-11-15 Degradable poly(vinyl alcohol) hydrogels
JP2001544794A JP2003516810A (en) 1999-11-15 2000-11-15 Degradable poly (vinyl alcohol) hydrogel

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16553199P 1999-11-15 1999-11-15
US60/165,531 1999-11-15

Publications (2)

Publication Number Publication Date
WO2001044307A2 WO2001044307A2 (en) 2001-06-21
WO2001044307A3 true WO2001044307A3 (en) 2002-02-07

Family

ID=22599297

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/042190 WO2001044307A2 (en) 1999-11-15 2000-11-15 Degradable poly(vinyl alcohol) hydrogels

Country Status (5)

Country Link
EP (1) EP1250361A2 (en)
JP (1) JP2003516810A (en)
AU (1) AU4902901A (en)
CA (1) CA2391618A1 (en)
WO (1) WO2001044307A2 (en)

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US6652883B2 (en) 2000-03-13 2003-11-25 Biocure, Inc. Tissue bulking and coating compositions
DE60130544T2 (en) 2000-03-13 2008-06-26 Biocure, Inc. EMBOLIC COMPOSITIONS
DE60115212T2 (en) 2000-03-13 2006-07-27 Biocure, Inc. BIOMEDICAL ARTICLES FROM HYDROGEL
JP2004504887A (en) * 2000-08-02 2004-02-19 アエスクラップ　アーゲー　ウント　コー　カーゲー Medical technology products, their production methods and their surgical uses
US20020122771A1 (en) * 2000-09-23 2002-09-05 Troy Holland Spray hydrogel wound dressings
WO2002072166A1 (en) * 2001-03-13 2002-09-19 Biocure, Inc. Compositions for drug delivery
US6713646B2 (en) 2002-04-12 2004-03-30 Biosphere Medical Degradable crosslinkers, and degradable crosslinked hydrogels comprising them
US6884905B2 (en) 2002-07-23 2005-04-26 Biosphere Medical Degradable carbamate-containing bis(acryloyl) crosslinkers, and degradable crosslinked hydrogels comprising them
JP4440888B2 (en) 2003-11-04 2010-03-24 スプラポリックス・ビー．ブイ． Production of supramolecular polymer containing 4-deuterium bond unit in polymer backbone
DE102004014633A1 (en) * 2004-03-22 2005-10-13 Aesculap Ag & Co. Kg Composition for adhesion prophylaxis
JP4655505B2 (en) * 2004-04-28 2011-03-23 東レ株式会社 Crosslinked biodegradable particles and method for producing the same
CA2572603C (en) 2004-06-29 2013-01-15 Biocure, Inc. Spinal disc nucleus pulposus implant
EP1773903B1 (en) 2004-07-12 2017-08-09 SupraPolix B.V. Supramolecular ionomers
US20060222596A1 (en) * 2005-04-01 2006-10-05 Trivascular, Inc. Non-degradable, low swelling, water soluble radiopaque hydrogel polymer
EP1877113B1 (en) 2005-05-04 2011-11-09 SupraPolix B.V. Modular bioresorbable or biomedical, biologically active supramolecular materials
TWI436793B (en) * 2006-08-02 2014-05-11 Baxter Int Rapidly acting dry sealant and methods for use and manufacture
GB0623043D0 (en) * 2006-11-18 2006-12-27 Univ Sheffield Sensor devices
WO2008063057A2 (en) 2006-11-20 2008-05-29 Suprapolix B.V. Supramolecular polymers from low-melting, easily processable building blocks
ATE515538T1 (en) 2007-03-23 2011-07-15 Suprapolix Bv STRONG REVERSIBLE HYDROGELS
US8628789B2 (en) 2007-03-23 2014-01-14 Suprapolix, B.V. Strong reversible hydrogels
US8754213B2 (en) 2008-07-04 2014-06-17 Suprapolix B.V. High flow supramolecular compounds
US9232805B2 (en) 2010-06-29 2016-01-12 Biocure, Inc. In-situ forming hydrogel wound dressings containing antimicrobial agents
EP2450394B1 (en) 2010-11-05 2017-06-07 SupraPolix B.V. A process for the preparation of a supramolecular polymer
PL2455104T3 (en) 2010-11-19 2013-12-31 Univ Freiburg Bio-functionalized stimulus-responsive dissolvable PEG-hydrogels
US20120231072A1 (en) * 2011-03-11 2012-09-13 Chemisches Institut Schaefer Ag Thermo-responsive hydrogel compositions
GB2521997A (en) * 2013-09-06 2015-07-15 Biocompatibles Uk Ltd Radiopaque polymers
WO2016018145A1 (en) 2014-07-28 2016-02-04 Suprapolix B.V. Durable hydrogen bonded hydrogels
JP7021197B2 (en) * 2016-09-05 2022-02-16 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング UV curable adhesion promoter based on functionalized polyvinyl alcohol
CN114099765B (en) * 2021-11-30 2022-10-28 上海汇禾医疗科技有限公司 Photo-initiated cross-linked polyvinyl alcohol drug-loaded embolism microsphere and preparation method thereof

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Also Published As

Publication number Publication date
JP2003516810A (en) 2003-05-20
EP1250361A2 (en) 2002-10-23
CA2391618A1 (en) 2001-05-21
AU4902901A (en) 2001-06-25
WO2001044307A2 (en) 2001-06-21

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