WO2001047498A3 - Hydrogel-driven layered drug dosage form comprising sertraline - Google Patents

Hydrogel-driven layered drug dosage form comprising sertraline Download PDF

Info

Publication number
WO2001047498A3
WO2001047498A3 PCT/IB2000/001871 IB0001871W WO0147498A3 WO 2001047498 A3 WO2001047498 A3 WO 2001047498A3 IB 0001871 W IB0001871 W IB 0001871W WO 0147498 A3 WO0147498 A3 WO 0147498A3
Authority
WO
WIPO (PCT)
Prior art keywords
sertraline
dosage form
hour
water
use environment
Prior art date
Application number
PCT/IB2000/001871
Other languages
French (fr)
Other versions
WO2001047498A2 (en
Inventor
William John Curatolo
Michael Bruce Fergione
Michael Christopher Roy
Avinash Govind Thombre
Kenneth Craig Waterman
Leah Elizabeth Appel
Ronald Arthur Beyerinck
Mark Brian Chidlaw
Dwayne Thomas Friesen
Danielle Supplee
Original Assignee
Pfizer Prod Inc
William John Curatolo
Michael Bruce Fergione
Michael Christopher Roy
Avinash Govind Thombre
Kenneth Craig Waterman
Leah Elizabeth Appel
Ronald Arthur Beyerinck
Mark Brian Chidlaw
Dwayne Thomas Friesen
Danielle Supplee
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc, William John Curatolo, Michael Bruce Fergione, Michael Christopher Roy, Avinash Govind Thombre, Kenneth Craig Waterman, Leah Elizabeth Appel, Ronald Arthur Beyerinck, Mark Brian Chidlaw, Dwayne Thomas Friesen, Danielle Supplee filed Critical Pfizer Prod Inc
Priority to MXPA02006335A priority Critical patent/MXPA02006335A/en
Priority to AU17243/01A priority patent/AU1724301A/en
Priority to CA002395231A priority patent/CA2395231C/en
Priority to JP2001548093A priority patent/JP2003518487A/en
Priority to EP00979866A priority patent/EP1239839A2/en
Priority to BR0016707-0A priority patent/BR0016707A/en
Publication of WO2001047498A2 publication Critical patent/WO2001047498A2/en
Publication of WO2001047498A3 publication Critical patent/WO2001047498A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

A controlled release dosage form for sertraline has a core comprising a sertraline-containing composition and a water-swellable composition wherein the water-swellable composition is in a separate region within the core. A coating around the core is water-permeable, water-insoluble, and has at least one delivery port therethrough. In one embodiment, the dosage form releases sertraline to the use environment at an average rate of 6 to 10 wt.% per hour from the second to the twentieth hour after introduction to a use environment and less than about 25 wt.% for the first two hours and at least 70 wt.% by the twelfth hour, where the percentages correspond to the mass of drug released from the tablet divided by the total mass of drug originally present in the tablet. In another embodiment, the dosage form releases less than about 25 wt.% of sertraline to the use environment by the second hour after introduction of the dosage form to the use environment, and delivers at least 25 wt.% from the eighth to the twenty-fourth hour.
PCT/IB2000/001871 1999-12-23 2000-12-13 Hydrogel-driven layered drug dosage form comprising sertraline WO2001047498A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
MXPA02006335A MXPA02006335A (en) 1999-12-23 2000-12-13 Hydrogeldriven layered drug dosage form.
AU17243/01A AU1724301A (en) 1999-12-23 2000-12-13 Hydrogel-driven layered drug dosage form
CA002395231A CA2395231C (en) 1999-12-23 2000-12-13 Hydrogel-driven layered drug dosage form
JP2001548093A JP2003518487A (en) 1999-12-23 2000-12-13 Hydrogel-driven laminated drug formulation
EP00979866A EP1239839A2 (en) 1999-12-23 2000-12-13 Hydrogel-driven layered drug dosage form comprising sertraline
BR0016707-0A BR0016707A (en) 1999-12-23 2000-12-13 Hydrogel-driven layered drug dosage form

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17210899P 1999-12-23 1999-12-23
US60/172,108 1999-12-23

Publications (2)

Publication Number Publication Date
WO2001047498A2 WO2001047498A2 (en) 2001-07-05
WO2001047498A3 true WO2001047498A3 (en) 2001-11-15

Family

ID=22626396

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2000/001871 WO2001047498A2 (en) 1999-12-23 2000-12-13 Hydrogel-driven layered drug dosage form comprising sertraline

Country Status (15)

Country Link
US (1) US6899896B2 (en)
EP (1) EP1239839A2 (en)
JP (1) JP2003518487A (en)
AR (1) AR027066A1 (en)
AU (1) AU1724301A (en)
BR (1) BR0016707A (en)
CA (1) CA2395231C (en)
CO (1) CO5271728A1 (en)
GT (1) GT200000220A (en)
MX (1) MXPA02006335A (en)
PA (1) PA8508901A1 (en)
PE (1) PE20010983A1 (en)
TN (1) TNSN00251A1 (en)
UY (1) UY26493A1 (en)
WO (1) WO2001047498A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9060941B2 (en) 2002-09-20 2015-06-23 Actavis, Inc. Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100523127B1 (en) * 1999-12-23 2005-10-20 화이자 프로덕츠 인코포레이티드 Hydrogel-driven drug dosage form
BR0211028A (en) * 2001-06-22 2004-06-15 Pfizer Prod Inc Aqueous solution, method for forming drug and polymer combinations, pharmaceutical compositions, method for forming a pharmaceutical composition and product
JP2004534812A (en) 2001-06-22 2004-11-18 ファイザー・プロダクツ・インク Pharmaceutical composition of dispersion of drug and neutral polymer
MXPA04002979A (en) * 2001-09-28 2005-06-20 Johnson & Johnson Modified release dosage forms.
US20040146559A1 (en) * 2002-09-28 2004-07-29 Sowden Harry S. Dosage forms having an inner core and outer shell with different shapes
EP1469832B2 (en) 2002-02-01 2016-10-26 Bend Research, Inc. Pharmaceutical compositions of amorphous dispersions of drugs and lipophilic microphase-forming materials
GB0203296D0 (en) 2002-02-12 2002-03-27 Glaxo Group Ltd Novel composition
US8637512B2 (en) 2002-07-29 2014-01-28 Glaxo Group Limited Formulations and method of treatment
ES2529180T3 (en) * 2002-09-20 2015-02-17 Andrx Labs Llc Multi-stage formulation containing a biguanide and a thiazolidinedione derivative
US7959946B2 (en) 2002-09-20 2011-06-14 Watson Pharmaceuticals, Inc. Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
US8084058B2 (en) 2002-09-20 2011-12-27 Watson Pharmaceuticals, Inc. Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
US7785627B2 (en) 2002-09-20 2010-08-31 Watson Pharmaceuticals, Inc. Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
US20040081695A1 (en) * 2002-09-28 2004-04-29 Sowden Harry S Dosage forms having an inner core and an outer shell
RU2310647C2 (en) * 2002-11-07 2007-11-20 Торрент Фармасьютикалз Лтд Method for preparing sertraline hydrochloride polymorphous formulation
CA2415154C (en) * 2002-12-24 2009-06-16 Biovail Laboratories Inc. Modified release formulations of selective serotonin re-uptake inhibitors
ATE540671T1 (en) 2003-08-04 2012-01-15 Bend Res Inc PHARMACEUTICAL COMPOSITIONS OF AMORPHOUS DRUG ADSORBATES AND LIPOPHILIC MICROPHASE-FORMING MATERIALS
WO2005117911A2 (en) * 2004-05-06 2005-12-15 Cydex, Inc. Taste-masked formulations containing sertraline and sulfoalkyl ether cyclodextrin
WO2006072878A1 (en) * 2005-01-07 2006-07-13 Ranbaxy Laboratories Limited Oral dosage forms of sertraline having controlled particle size and processes for their preparation
US20060233882A1 (en) * 2005-04-15 2006-10-19 Sowden Harry S Osmotic dosage form
US20060239956A1 (en) * 2005-04-26 2006-10-26 Lulu Henson Preparation and use of hydrogels
CN101299993A (en) * 2005-11-04 2008-11-05 伊士曼化工公司 Carboxyalkylcellulose esters for administration of poorly soluble pharmaceutically active agents
WO2007057762A2 (en) * 2005-11-16 2007-05-24 Pfizer Limited Osmotic bi-layer tablet
CN100563637C (en) * 2006-10-13 2009-12-02 北京红林制药有限公司 A kind of medicated core compositions of controlled release drug administration and controlled release preparation and preparation method thereof
ECSP077628A (en) * 2007-05-03 2008-12-30 Smithkline Beechman Corp NEW PHARMACEUTICAL COMPOSITION
AU2010325894B2 (en) * 2009-12-04 2015-07-30 Sunovion Pharmaceuticals Inc. Formulations, salts and polymorphs of transnorsertraline and uses thereof
US10485770B2 (en) 2009-12-21 2019-11-26 Aptapharma, Inc. Functionally-coated multilayer tablets
WO2016020936A2 (en) * 2014-07-21 2016-02-11 Patel Jayendrakumar Dasharathlal A novel oral gastroretentive pharmaceutical dosage form
JP6455293B2 (en) * 2015-04-21 2019-01-23 ニプロ株式会社 Formulation containing sertraline and / or a pharmaceutically acceptable salt thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997037640A2 (en) * 1996-04-05 1997-10-16 Alza Corporation Uniform drug delivery therapy
WO1999001121A1 (en) * 1997-07-01 1999-01-14 Pfizer Inc. Sertraline salts and sustained-release dosage forms of sertraline
EP1027888A2 (en) * 1999-02-10 2000-08-16 Pfizer Products Inc. Osmotic system for delivery of solid amorphous dispersions of drugs

Family Cites Families (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4536518A (en) 1979-11-01 1985-08-20 Pfizer Inc. Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
US4327725A (en) 1980-11-25 1982-05-04 Alza Corporation Osmotic device with hydrogel driving member
US5366738A (en) 1982-07-29 1994-11-22 Merck & Co., Inc. Controlled release drug dispersion delivery device
US4612008A (en) 1983-05-11 1986-09-16 Alza Corporation Osmotic device with dual thermodynamic activity
US4783337A (en) 1983-05-11 1988-11-08 Alza Corporation Osmotic system comprising plurality of members for dispensing drug
US5082668A (en) 1983-05-11 1992-01-21 Alza Corporation Controlled-release system with constant pushing source
US4765989A (en) 1983-05-11 1988-08-23 Alza Corporation Osmotic device for administering certain drugs
USRE33994E (en) 1983-08-16 1992-07-14 Burroughs Wellcome Co. Pharmaceutical delivery system
US4968507A (en) 1984-06-20 1990-11-06 Merck & Co., Inc. Controlled porosity osmotic pump
US4609374A (en) 1985-04-22 1986-09-02 Alza Corporation Osmotic device comprising means for governing initial time of agent release therefrom
US4624847A (en) 1985-04-22 1986-11-25 Alza Corporation Drug delivery device for programmed delivery of beneficial drug
GB8518301D0 (en) 1985-07-19 1985-08-29 Fujisawa Pharmaceutical Co Hydrodynamically explosive systems
US4865598A (en) 1985-08-16 1989-09-12 Alza Corporation Dispensing system for administering beneficial agent
GB8521494D0 (en) 1985-08-29 1985-10-02 Zyma Sa Controlled release tablet
IT1188212B (en) 1985-12-20 1988-01-07 Paolo Colombo SYSTEM FOR THE RELEASE SPEED OF ACTIVE SUBSTANCES
US4755180A (en) 1986-06-16 1988-07-05 Alza Corporation Dosage form comprising solubility regulating member
DE3868077D1 (en) 1987-01-14 1992-03-12 Ciba Geigy Ag THERAPEUTIC SYSTEM FOR HEAVY-SOLUBLE ACTIVE SUBSTANCES.
US4915954A (en) 1987-09-03 1990-04-10 Alza Corporation Dosage form for delivering a drug at two different rates
US4946687A (en) 1987-10-02 1990-08-07 Alza Corporation Dosage form for treating cardiovascular diseases
US4971998A (en) 1987-10-22 1990-11-20 Massachusetts Institute Of Technology Methods for treating the premenstrual or late luteal phase syndrome
US4837111A (en) 1988-03-21 1989-06-06 Alza Corporation Dosage form for dispensing drug for human therapy
FI101344B1 (en) 1988-03-31 1998-06-15 Tanabe Seiyaku Co Process for the preparation of a composition for controlled release of a pharmaceutically active substance
US5030456A (en) 1988-11-07 1991-07-09 Alza Corporation Dosage form for treating cardiovascular diseases
US5034229A (en) 1988-12-13 1991-07-23 Alza Corporation Dispenser for increasing feed conversion of hog
IL92966A (en) 1989-01-12 1995-07-31 Pfizer Dispensing devices powered by hydrogel
DD295760A5 (en) 1989-01-31 1991-11-14 Martin-Luther-Universitaet Halle Wittenberg,De DRUG DISTRIBUTION SYSTEM WITH COTROLLED ACTIVE INGREDIENT TRANSFER
US4981870A (en) 1989-03-07 1991-01-01 Pfizer Inc. Use of 4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine derivatives in the treatment of psychosis, inflammation and as immunosuppressants
US5019396A (en) 1989-05-12 1991-05-28 Alza Corporation Delivery dispenser for treating cardiac arrhythmias
US5126142A (en) 1989-07-18 1992-06-30 Alza Corporation Dispenser comprising ionophore
US5273752A (en) 1989-07-18 1993-12-28 Alza Corporation Controlled release dispenser comprising beneficial agent
US4940731A (en) 1989-08-30 1990-07-10 Pfizer Inc. Method of treating premature ejaculation using sertraline
US5130338A (en) 1989-08-30 1992-07-14 Pfizer Inc. Method of treating chemical dependencies using sertraline
US5091190A (en) 1989-09-05 1992-02-25 Alza Corporation Delivery system for administration blood-glucose lowering drug
US5035897A (en) 1989-09-05 1991-07-30 Alza Corporation Dosage form for delivering soluble or insoluble drugs
US4962128A (en) 1989-11-02 1990-10-09 Pfizer Inc. Method of treating anxiety-related disorders using sertraline
US5120548A (en) 1989-11-07 1992-06-09 Merck & Co., Inc. Swelling modulated polymeric drug delivery device
US5200197A (en) 1989-11-16 1993-04-06 Alza Corporation Contraceptive pill
US5178866A (en) 1990-03-23 1993-01-12 Alza Corporation Dosage form for delivering drug to the intestine
US5190763A (en) 1990-05-07 1993-03-02 Alza Corporation Dosage form indicated for the management of abnormal posture, tremor and involuntary movement
US5221536A (en) 1990-05-07 1993-06-22 Alza Corporation Dosage form indicated for the management of abnormal posture, tremor and involuntary movement
US5192550A (en) 1990-05-07 1993-03-09 Alza Corporation Dosage form for treating central nervous system disorders
US5057321A (en) 1990-06-13 1991-10-15 Alza Corporation Dosage form comprising drug and maltodextrin
US5128145A (en) 1990-06-13 1992-07-07 Alza Corporation Dosage form for Parkinson's disease, spasticity and muscle spasms
US5156850A (en) 1990-08-31 1992-10-20 Alza Corporation Dosage form for time-varying patterns of drug delivery
DE69102140T2 (en) 1990-09-28 1994-09-08 Pfizer ACTIVE SUBSTANCE DELIVERY DEVICE CONTAINING A HYDROPHOBIC AGENT.
US5284662A (en) 1990-10-01 1994-02-08 Ciba-Geigy Corp. Oral osmotic system for slightly soluble active agents
US5208037A (en) 1991-04-22 1993-05-04 Alza Corporation Dosage forms comprising polymers comprising different molecular weights
US5160744A (en) 1991-06-27 1992-11-03 Alza Corporation Verapmil therapy
US5178867A (en) 1991-08-19 1993-01-12 Alza Corporation Dosage form for delivering drug in short-time period
CA2115648C (en) 1991-10-10 2002-04-09 Eun Soo Lee Osmotic drug delivery devices with hydrophobic wall materials
US5183942A (en) 1991-11-05 1993-02-02 The Scripps Research Institute Ten-membered ring enediynediols and enediynediones having DNA cleaving properties
US5543154A (en) 1991-12-27 1996-08-06 Merck & Co., Inc. Controlled release nifedipine delivery device
US5294770A (en) 1992-01-14 1994-03-15 Alza Corporation Laser tablet treatment system with dual access to tablet
US5246711A (en) 1992-02-27 1993-09-21 Alza Corporation Dosage form for treating dysthymia
US5185158A (en) 1992-02-27 1993-02-09 Alza Corporation Dosage form comprising succinimide drug for treating depressive disorders and composition comprising same
US5688518A (en) 1992-02-27 1997-11-18 Alza Corporation Antidepressive therapy
US5246710A (en) 1992-02-27 1993-09-21 Alza Corporation Dosage form for treating cyclothymia
US5609885A (en) 1992-09-15 1997-03-11 Alza Corporation Osmotic membrane and delivery device
US5260069A (en) 1992-11-27 1993-11-09 Anda Sr Pharmaceuticals Inc. Pulsatile particles drug delivery system
US5358721A (en) 1992-12-04 1994-10-25 Alza Corporation Antiviral therapy
ATE195252T1 (en) 1993-04-23 2000-08-15 Novartis Erfind Verwalt Gmbh DRUG DELIVERY DEVICE WITH CONTROLLED RELEASE
US6287598B1 (en) 1993-05-28 2001-09-11 Alza Corporation Method for providing sustained antiepileptic therapy
US5455046A (en) 1993-09-09 1995-10-03 Edward Mendell Co., Inc. Sustained release heterodisperse hydrogel systems for insoluble drugs
HU213407B (en) 1993-12-09 1997-06-30 Egyt Gyogyszervegyeszeti Gyar Process for producing tablet with diffusive-osmotic release
US5458887A (en) 1994-03-02 1995-10-17 Andrx Pharmaceuticals, Inc. Controlled release tablet formulation
US5458888A (en) 1994-03-02 1995-10-17 Andrx Pharmaceuticals, Inc. Controlled release tablet formulation
ZA953078B (en) 1994-04-28 1996-01-05 Alza Corp Effective therapy for epilepsies
AU680356B2 (en) 1994-05-06 1997-07-24 Pfizer Inc. Controlled-release dosage forms of azithromycin
US5698224A (en) 1994-06-27 1997-12-16 Alza Corporation Tacrine therapy
US5529787A (en) 1994-07-07 1996-06-25 Alza Corporation Hydromorphone therapy
US5718700A (en) 1994-09-20 1998-02-17 Alza Corporation Exit means in dosage form
US5658474A (en) 1994-12-16 1997-08-19 Alza Corporation Method and apparatus for forming dispenser delivery ports
US5607696A (en) 1995-02-10 1997-03-04 Alza Corporation Osmotic membrane and delivery device
US5736159A (en) 1995-04-28 1998-04-07 Andrx Pharmaceuticals, Inc. Controlled release formulation for water insoluble drugs in which a passageway is formed in situ
US5654005A (en) 1995-06-07 1997-08-05 Andrx Pharmaceuticals, Inc. Controlled release formulation having a preformed passageway
US5840332A (en) 1996-01-18 1998-11-24 Perio Products Ltd. Gastrointestinal drug delivery system
US5837379A (en) 1997-01-31 1998-11-17 Andrx Pharmaceuticals, Inc. Once daily pharmaceutical tablet having a unitary core
AU7706598A (en) 1997-05-30 1998-12-30 Laboratorios Phoenix U.S.A., Inc. Multi-layered osmotic device

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997037640A2 (en) * 1996-04-05 1997-10-16 Alza Corporation Uniform drug delivery therapy
WO1999001121A1 (en) * 1997-07-01 1999-01-14 Pfizer Inc. Sertraline salts and sustained-release dosage forms of sertraline
EP1027888A2 (en) * 1999-02-10 2000-08-16 Pfizer Products Inc. Osmotic system for delivery of solid amorphous dispersions of drugs

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9060941B2 (en) 2002-09-20 2015-06-23 Actavis, Inc. Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative

Also Published As

Publication number Publication date
AU1724301A (en) 2001-07-09
CA2395231C (en) 2006-08-15
JP2003518487A (en) 2003-06-10
AR027066A1 (en) 2003-03-12
WO2001047498A2 (en) 2001-07-05
US6899896B2 (en) 2005-05-31
MXPA02006335A (en) 2002-12-13
PE20010983A1 (en) 2001-10-01
UY26493A1 (en) 2001-07-31
BR0016707A (en) 2002-09-03
GT200000220A (en) 2002-06-14
CO5271728A1 (en) 2003-04-30
PA8508901A1 (en) 2003-12-10
TNSN00251A1 (en) 2002-05-30
EP1239839A2 (en) 2002-09-18
US20010044474A1 (en) 2001-11-22
CA2395231A1 (en) 2001-07-05

Similar Documents

Publication Publication Date Title
WO2001047498A3 (en) Hydrogel-driven layered drug dosage form comprising sertraline
AP2002002553A0 (en) Hydrogel-driven Drug Dosoge Form.
CA2191178A1 (en) Long-lasting release nifedipine preparation
MY127797A (en) 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol-containing pharmaceutical composition with slow release of active indgredient
AU5680100A (en) Controlled release and taste masking oral pharmaceutical compositions
CA2232450A1 (en) Oral pharmaceutical composition containing antimicrobial actives and sustained release pantoprazole
BG102228A (en) Medicamentous form with controlled release of slightly soluble medicamentous substances
AU6517596A (en) Oral pharmaceutical compositions with delayed release of reversible proton pump inhibitors
WO2003103637A3 (en) Modified release, multiple unit drug delivery systems
CA2199778A1 (en) Extended release formulation of venlafaxine
CA2346001A1 (en) Controlled release nanoparticulate compositions
WO2001052823A3 (en) Compositions to effect the release profile in the transdermal administration of drugs
WO2007052125A3 (en) Solid oral pharmaceutical compositions for once daily dosing containing pregabalin, a matrix forming agent and a swelling agent
GEP20022851B (en) Flash-Melt Oral Dosage Formulation
NZ524767A (en) Composition for the transdermal delivery of fentanyl
CA2622805A1 (en) Compressed tablets comprising valsartan
CA2312936A1 (en) Compositions and methods for weight reduction
WO2005016306A3 (en) Uniform delivery of topiramate over prolonged period of time with enhanced dispersion formulation
MXPA02006603A (en) Brittle-coating, soft core dosage form.
HK1067299A1 (en) Pharmaceutical compositions containing terbinafineand use thereof
CA2256751A1 (en) Coated trimebutine maleate tablet
CA2340898A1 (en) Compositions and methods for treating intracellular infections
AU2697100A (en) Pharmaceutical capsule compositions containing loratadine and pseudoephedrine
WO2005020957A3 (en) Stepwise delivery of topiramate over prolonged period of time
EP1782798A3 (en) Ascending-dose dosage form

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 2000979866

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2395231

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: PA/a/2002/006335

Country of ref document: MX

ENP Entry into the national phase

Ref country code: JP

Ref document number: 2001 548093

Kind code of ref document: A

Format of ref document f/p: F

WWP Wipo information: published in national office

Ref document number: 2000979866

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWW Wipo information: withdrawn in national office

Ref document number: 2000979866

Country of ref document: EP