WO2001055297A3 - Dreidimensionalen matrixkörper und vorrichtung sowie verfahren zum messen von kontraktionen eines zellgewebes - Google Patents
Dreidimensionalen matrixkörper und vorrichtung sowie verfahren zum messen von kontraktionen eines zellgewebes Download PDFInfo
- Publication number
- WO2001055297A3 WO2001055297A3 PCT/EP2001/000856 EP0100856W WO0155297A3 WO 2001055297 A3 WO2001055297 A3 WO 2001055297A3 EP 0100856 W EP0100856 W EP 0100856W WO 0155297 A3 WO0155297 A3 WO 0155297A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- relates
- cell
- cell culture
- dimensional matrix
- cell tissue
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M21/00—Bioreactors or fermenters specially adapted for specific uses
- C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/10—Petri dish
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/12—Well or multiwell plates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0657—Cardiomyocytes; Heart cells
Abstract
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001561132A JP2004500093A (ja) | 2000-01-27 | 2001-01-26 | 3次元マトリックス体、細胞組織の収縮を測定する装置および方法 |
EP01909695A EP1250416B1 (de) | 2000-01-27 | 2001-01-26 | Künstlich hergestelltes, dreidimensionales Säugerherzmuskelgewebe und Herstellungsverfahren |
DE50109950T DE50109950D1 (de) | 2000-01-27 | 2001-01-26 | Künstlich hergestelltes, dreidimensionales Säugerherzmuskelgewebe und Herstellungsverfahren |
CA002398084A CA2398084A1 (en) | 2000-01-27 | 2001-01-26 | Three-dimensional matrix body, and device and method for measuring contractions of a cell tissue |
AU2001237345A AU2001237345A1 (en) | 2000-01-27 | 2001-01-26 | Three-dimensional matrix body, and device and method for measuring contractions of a cell tissue |
US10/182,131 US7618452B2 (en) | 2000-01-27 | 2001-01-26 | Artificially produced, three-dimensional muscle tissue |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10003521.3 | 2000-01-27 | ||
DE10003521A DE10003521A1 (de) | 2000-01-27 | 2000-01-27 | Vorrichtung zum Herstellen eines dreidimensionalen Matrixkörpers, Multi-Well-Platte, Lösung zum Kultivieren von Säugerkardiomyocyten, Verfahren zum Kultivieren einer Zellkultur, Vorrichtung für die Messung isometrischer Kraftparameter von Zellkulturen sowie Verfahren zum meßbaren Verfolgen von Kontraktionen eines in eine Trägersubstanz eingelagerten Zellgewebes |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2001055297A2 WO2001055297A2 (de) | 2001-08-02 |
WO2001055297A3 true WO2001055297A3 (de) | 2002-02-07 |
Family
ID=7628900
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2001/000856 WO2001055297A2 (de) | 2000-01-27 | 2001-01-26 | Dreidimensionalen matrixkörper und vorrichtung sowie verfahren zum messen von kontraktionen eines zellgewebes |
Country Status (9)
Country | Link |
---|---|
US (1) | US7618452B2 (de) |
EP (1) | EP1250416B1 (de) |
JP (1) | JP2004500093A (de) |
AT (1) | ATE328065T1 (de) |
AU (1) | AU2001237345A1 (de) |
CA (1) | CA2398084A1 (de) |
DE (2) | DE10003521A1 (de) |
ES (1) | ES2265414T3 (de) |
WO (1) | WO2001055297A2 (de) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
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US8227240B2 (en) | 2001-08-14 | 2012-07-24 | The Washington University | Systems for screening pharmaceutical chemicals |
CA2497343C (en) | 2001-08-14 | 2013-04-02 | Washington University In St. Louis | Systems and methods for screening pharmaceutical chemicals |
JP4566008B2 (ja) * | 2003-05-23 | 2010-10-20 | ホイゼルマン・ハンス・イェルク | インビトロの組織を機械的に活性化する方法および装置 |
DE602004030254D1 (de) | 2003-08-01 | 2011-01-05 | Two Cells Co Ltd | Scaffoldfreies, selbstorganisiertes, 3 dimensionales, synthetisches gewebe |
WO2007083504A1 (ja) * | 2003-08-01 | 2007-07-26 | Norimasa Nakamura | スキャフォールドフリー自己組織性三次元人工組織(Scaffold-free Self-Organized 3D synthetic tissue) |
US20080145921A1 (en) * | 2003-09-29 | 2008-06-19 | Danish Myo Technology A/S | Tissue Bath System With Air Heating |
US20070178584A1 (en) * | 2004-03-11 | 2007-08-02 | Nagoya Industrial Science Research Institute | Culture device |
WO2006102890A1 (en) * | 2005-03-29 | 2006-10-05 | Danish Myo Technology A/S | Tissue bath system with gas heating |
EP1783206A1 (de) * | 2005-11-08 | 2007-05-09 | Universitätsklinikum Hamburg-Eppendorf | Polyzyklisches künstliches Herzgewebe |
JP5409009B2 (ja) * | 2005-12-01 | 2014-02-05 | エイジェンシー フォー サイエンス,テクノロジー アンド リサーチ | 組織工学の足場としての三次元再構成細胞外マトリクス |
WO2007107038A1 (fr) * | 2006-03-20 | 2007-09-27 | Hua Liu | Construction d'un modèle tumoral in vitro et application |
EP1920789A1 (de) * | 2006-11-11 | 2008-05-14 | Universitätsklinikum Hamburg-Eppendorf | Beutelartige Konstruktion mit Gewebe von Säugern |
EP2294177B8 (de) * | 2008-06-05 | 2016-12-21 | InvivoSciences, Inc. | Dreidimensionale gewebe für testverfahren mit hohem durchsatz |
EP2459986B1 (de) * | 2009-07-28 | 2020-11-04 | Menixis Limited | Vorrichtung und verfahren für nachweis und analyse von partikeln in fluiden |
US10034738B2 (en) | 2012-12-07 | 2018-07-31 | The Governing Council Of The University Of Toronto | Cardiac tissue constructs and methods of fabrication thereof |
EP2743345A1 (de) | 2012-12-13 | 2014-06-18 | IMBA-Institut für Molekulare Biotechnologie GmbH | Dreidimensionale heterogen differenzierte Gewebekultur |
EP2784149A1 (de) * | 2013-03-25 | 2014-10-01 | Technische Universität Hamburg-Harburg | Verfahren und Vorrichtung zur Messung von Kontraktionseigenschaften von künstlich hergestellten Herzgewebe-Konstrukten |
DK2840132T3 (en) | 2013-08-22 | 2017-02-20 | Georg-August-Universität Göttingen Stiftung Öffenlichen Rechts Universitätsmedizin | Method of Manufacturing Constructed Heart Muscle (EHM) |
ES2706401T3 (es) | 2013-08-30 | 2019-03-28 | Georg August Univ Goettingen Stiftung Oeffentlichen Rechts Univsmedizin | Estructura saquiforme con actividad paracrina y métodos para su preparación |
EP3176252A1 (de) | 2015-12-04 | 2017-06-07 | Ludwig-Maximilians-Universität München | System und verfahren zur bestimmung einer kraft, die auf eine zell- oder gewebekultur angewendet oder dadurch erzeugt wird |
EP3190176A1 (de) | 2016-01-11 | 2017-07-12 | IMBA-Institut für Molekulare Biotechnologie GmbH | Verfahren zur gewebekulturentwicklung auf einem gerüst und differenzierte gewebekultur |
WO2017156455A1 (en) | 2016-03-11 | 2017-09-14 | University Of Washington | System for magnetic detection of myocardial forces |
DE102016110328B3 (de) | 2016-06-03 | 2017-09-07 | Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin | Lochplatte |
JPWO2018124210A1 (ja) * | 2016-12-28 | 2019-10-31 | 国立大学法人京都大学 | 環状心筋細胞塊 |
EP3395942A1 (de) | 2017-04-25 | 2018-10-31 | IMBA-Institut für Molekulare Biotechnologie GmbH | Bi- oder multi-differenziertes organoid |
JP2020523027A (ja) | 2017-06-16 | 2020-08-06 | イーエムベーアー−インスティテュート フュール モレクラレ バイオテクノロジー ゲゼルシャフト ミット ベシュレンクテル ハフツング | 血管オルガノイド、オルガノイドの製造及び使用方法 |
EP3681998A1 (de) | 2017-09-11 | 2020-07-22 | IMBA-Institut für Molekulare Biotechnologie GmbH | Tumororganoidmodell |
WO2019200042A1 (en) * | 2018-04-11 | 2019-10-17 | Trustees Of Boston University | Engineered platform to generate 3d cardiac tissues |
US20230078423A1 (en) | 2020-02-05 | 2023-03-16 | Lifetaq-Analytics Gmbh | Three-dimensional cell culture |
EP4150049A1 (de) * | 2020-05-15 | 2023-03-22 | Westfälische Wilhelms-Universität Münster | Kulturplattform zur gewebezüchtung und verfahren zur beobachtung von darin kultiviertem gewebe |
CN111690614B (zh) * | 2020-05-27 | 2023-09-22 | 吴宏伟 | 一种标准化肿瘤动物模型的建立方法及培养装置 |
EP4029537A1 (de) * | 2021-01-19 | 2022-07-20 | Universitätsklinikum Hamburg-Eppendorf | Gezüchtetes herzgewebspflaster, vorrichtung und verfahren zu dessen herstellung |
WO2023230603A2 (en) * | 2022-05-26 | 2023-11-30 | Trustees Of Tufts College | Systems and methods for making biological robots |
EP4286513A1 (de) | 2022-06-03 | 2023-12-06 | IMBA-Institut für Molekulare Biotechnologie GmbH | Dreifache gewebekulturfusion |
Citations (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3540985A (en) * | 1968-11-22 | 1970-11-17 | Leo Gross | Microbiological inhibition testing device |
US3902972A (en) * | 1973-02-02 | 1975-09-02 | Corning Glass Works | Modified petri dish for automatic inoculation |
US3985608A (en) * | 1969-05-03 | 1976-10-12 | Rolf Saxholm | Supporting element for use in microbiological, serological, immunological, clinical-chemical and similar laboratory work |
US4140582A (en) * | 1969-05-03 | 1979-02-20 | Rolf Saxholm | Supporting element for use in microbiological, serological, immunological clinical-chemical and similar laboratory work |
EP0218065A2 (de) * | 1985-08-30 | 1987-04-15 | THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce | Wiederhergestellter Basalmembrankomplex mit biologischer Aktivität |
JPH02154679A (ja) * | 1988-12-06 | 1990-06-14 | Mochida Pharmaceut Co Ltd | 医療用検査容器 |
US4975377A (en) * | 1987-05-14 | 1990-12-04 | Key Marc E | Cell growth chambers and method of use thereof |
US5153136A (en) * | 1988-07-22 | 1992-10-06 | Vandenburgh Herman H | Apparatus for growing tissue specimens in vitro |
JPH0632345A (ja) * | 1992-07-10 | 1994-02-08 | Sony Corp | シャーレ |
DE19500498A1 (de) * | 1995-01-10 | 1996-07-11 | Thomas Dr Med Eschenhagen | Matrixkörper für die Messung isometrischer Kraftparameter von Zellgewebe, Verfahren zum Kultivieren von Muskelzellen in Kollagengel und zum gleichzeitigen Herstellen von Muskelgewebe enthaltenden Matrixkörpern für die Messung von isometrischen Kraftparametern an diesen Körpern, sowie Vorrichtung zur Durchführung des Verfahrens |
EP0751215A2 (de) * | 1995-06-29 | 1997-01-02 | Becton, Dickinson and Company | Kulturgefäss zum Gebrauch mit Kulturplatten |
DE19843234A1 (de) * | 1998-09-09 | 2000-03-23 | Inst Pflanzengenetik & Kultur | Differenzierte Herzzellen mit pathologischen Merkmalen als in vitro-Modell für Herzerkrankungen |
Family Cites Families (6)
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NO124603B (de) * | 1969-05-03 | 1972-05-08 | Rolf Saxholm | |
US5605836A (en) * | 1995-06-13 | 1997-02-25 | Chen; Chin-Yu | Modular method and device for the evaluation of the ability of biocide to penetrate biofilm |
US6110459A (en) * | 1997-05-28 | 2000-08-29 | Mickle; Donald A. G. | Transplants for myocardial scars and methods and cellular preparations |
US6866842B1 (en) * | 1998-05-01 | 2005-03-15 | University Of Pittsburgh | Muscle-derived cells (MDCs) for treating muscle-or bone-related injury or dysfunction |
US6034053A (en) * | 1998-07-13 | 2000-03-07 | Wayne Hughes Institute | EGF-isoflavone conjugates for the prevention of restenosis |
DE19903506C2 (de) * | 1999-01-29 | 2002-04-04 | Inst Chemo Biosensorik | Verfahren, Gefäß und Vorrichtung zur Überwachung der Stoffwechselaktivität von Zellkulturen in flüssigen Medien |
-
2000
- 2000-01-27 DE DE10003521A patent/DE10003521A1/de not_active Withdrawn
-
2001
- 2001-01-26 ES ES01909695T patent/ES2265414T3/es not_active Expired - Lifetime
- 2001-01-26 DE DE50109950T patent/DE50109950D1/de not_active Expired - Lifetime
- 2001-01-26 CA CA002398084A patent/CA2398084A1/en not_active Abandoned
- 2001-01-26 AU AU2001237345A patent/AU2001237345A1/en not_active Withdrawn
- 2001-01-26 AT AT01909695T patent/ATE328065T1/de active
- 2001-01-26 US US10/182,131 patent/US7618452B2/en active Active
- 2001-01-26 WO PCT/EP2001/000856 patent/WO2001055297A2/de active IP Right Grant
- 2001-01-26 JP JP2001561132A patent/JP2004500093A/ja active Pending
- 2001-01-26 EP EP01909695A patent/EP1250416B1/de not_active Expired - Lifetime
Patent Citations (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3540985A (en) * | 1968-11-22 | 1970-11-17 | Leo Gross | Microbiological inhibition testing device |
US3985608A (en) * | 1969-05-03 | 1976-10-12 | Rolf Saxholm | Supporting element for use in microbiological, serological, immunological, clinical-chemical and similar laboratory work |
US4140582A (en) * | 1969-05-03 | 1979-02-20 | Rolf Saxholm | Supporting element for use in microbiological, serological, immunological clinical-chemical and similar laboratory work |
US3902972A (en) * | 1973-02-02 | 1975-09-02 | Corning Glass Works | Modified petri dish for automatic inoculation |
EP0218065A2 (de) * | 1985-08-30 | 1987-04-15 | THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce | Wiederhergestellter Basalmembrankomplex mit biologischer Aktivität |
US4975377A (en) * | 1987-05-14 | 1990-12-04 | Key Marc E | Cell growth chambers and method of use thereof |
US5153136A (en) * | 1988-07-22 | 1992-10-06 | Vandenburgh Herman H | Apparatus for growing tissue specimens in vitro |
JPH02154679A (ja) * | 1988-12-06 | 1990-06-14 | Mochida Pharmaceut Co Ltd | 医療用検査容器 |
JPH0632345A (ja) * | 1992-07-10 | 1994-02-08 | Sony Corp | シャーレ |
DE19500498A1 (de) * | 1995-01-10 | 1996-07-11 | Thomas Dr Med Eschenhagen | Matrixkörper für die Messung isometrischer Kraftparameter von Zellgewebe, Verfahren zum Kultivieren von Muskelzellen in Kollagengel und zum gleichzeitigen Herstellen von Muskelgewebe enthaltenden Matrixkörpern für die Messung von isometrischen Kraftparametern an diesen Körpern, sowie Vorrichtung zur Durchführung des Verfahrens |
EP0751215A2 (de) * | 1995-06-29 | 1997-01-02 | Becton, Dickinson and Company | Kulturgefäss zum Gebrauch mit Kulturplatten |
DE19843234A1 (de) * | 1998-09-09 | 2000-03-23 | Inst Pflanzengenetik & Kultur | Differenzierte Herzzellen mit pathologischen Merkmalen als in vitro-Modell für Herzerkrankungen |
Non-Patent Citations (2)
Title |
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PATENT ABSTRACTS OF JAPAN vol. 014, no. 406 (C - 0754) 4 September 1990 (1990-09-04) * |
PATENT ABSTRACTS OF JAPAN vol. 018, no. 245 (M - 1603) 11 May 1994 (1994-05-11) * |
Also Published As
Publication number | Publication date |
---|---|
DE10003521A1 (de) | 2001-08-09 |
AU2001237345A1 (en) | 2001-08-07 |
ES2265414T3 (es) | 2007-02-16 |
EP1250416B1 (de) | 2006-05-31 |
JP2004500093A (ja) | 2004-01-08 |
WO2001055297A2 (de) | 2001-08-02 |
US7618452B2 (en) | 2009-11-17 |
EP1250416A2 (de) | 2002-10-23 |
CA2398084A1 (en) | 2001-08-02 |
DE50109950D1 (de) | 2006-07-06 |
ATE328065T1 (de) | 2006-06-15 |
US20030091979A1 (en) | 2003-05-15 |
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