WO2001062209A2 - Dental cleaning agents containing propellant gas - Google Patents

Dental cleaning agents containing propellant gas Download PDF

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Publication number
WO2001062209A2
WO2001062209A2 PCT/EP2001/001721 EP0101721W WO0162209A2 WO 2001062209 A2 WO2001062209 A2 WO 2001062209A2 EP 0101721 W EP0101721 W EP 0101721W WO 0162209 A2 WO0162209 A2 WO 0162209A2
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WIPO (PCT)
Prior art keywords
weight
agent according
cleaning agent
propellant gas
tooth cleaning
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PCT/EP2001/001721
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German (de)
French (fr)
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WO2001062209A3 (en
Inventor
Hans-Theo Leinen
Guido Poschen
Peter Wülknitz
Christian Bressler
Original Assignee
Henkel Kommanditgesellschaft Auf Aktien
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Application filed by Henkel Kommanditgesellschaft Auf Aktien filed Critical Henkel Kommanditgesellschaft Auf Aktien
Priority to AU2001233770A priority Critical patent/AU2001233770A1/en
Publication of WO2001062209A2 publication Critical patent/WO2001062209A2/en
Publication of WO2001062209A3 publication Critical patent/WO2001062209A3/en

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/02Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04Dispersions; Emulsions
    • A61K8/046Aerosols; Foams

Definitions

  • the invention relates to a propellant-containing tooth cleaning and care agent in a dispenser system, which is released as a paste or gel strand when a valve is actuated and then swells slowly through the release of the propellant gas and develops a fine-bubble, stable foam.
  • Tooth cleaning agents are available in various forms and primarily serve to clean the tooth surface ; and prevention of tooth and gum disease. They usually contain a combination of polishing agents, humectants, surfactants, binders, flavorings and fluoride-containing and anti-microbial agents.
  • tooth cleaning agents are mainly offered in paste, cream and translucent or transparent gel form.
  • liquid or liquid toothpastes and mouthwashes have also become increasingly important.
  • a disadvantage of the products in paste, cream or gel form is their comparatively high viscosity and the resulting poor spreadability and slow release of the active ingredients and flavorings.
  • Foamed toothpastes which are usually dispensed from aerosol dispensers, improve the spreadability.
  • Such formulations are known from WO 99/22704, WO 82/03975, EP 0 208 009, AU 8542824, DE 2 217 953, DE 36 23 934, JP 5714520 A and JP 5714521 A.
  • CFCs, carbon dioxide, oxygen and low-boiling hydrocarbons are used as propellants.
  • fluorine-chlorine hydrocarbons CFCs
  • toothpaste foams are emulsions or dispersions that are released from the dispensers in an already foamed form.
  • the task was therefore to develop a dentifrice and care product with improved spreadability, which is initially dispensed from a dispenser as a non-foamed or only slightly foamed, and then gradually - especially when applied in the mouth - with a mousse-like, "tingling" foam
  • Another task was to optimize the composition in such a way that the propellant gas and toothpaste base form a stable dispersion that does not separate or blocks the line system of the dispenser.
  • a tooth cleaning agent containing a) at least one polishing agent b) at least one humectant c) at least one surfactant d) at least one oil / fat and / or wax component, characterized in that it is used together with a propellant gas or propellant gas mixture in a dispenser system is filled with a manually operated valve.
  • compositions according to the invention are stable against separation of the propellant gas / propellant gas mixture. Blockage of the donor's piping does not occur.
  • the composition according to the invention is dispensed from the dispenser in the form of a gel-like, not or only slightly foamed strand which forms an extremely stable, fine-bubble mousse through the gradual escape of the propellant gas / propellant gas mixture. This ensures a higher amount of active ingredient compared to preparations that are taken directly from the donors as voluminous foam.
  • the proportion of water in the composition according to the invention is 1-60% by weight, preferably 5-50% by weight and in particular 30-50% by weight.
  • the tooth cleaning agent usually has a pH of 5.5-9, preferably 6.5-8.0 and in particular 7.0-7.3.
  • compositions according to the invention are suitable for cleaning and caring for the teeth and for preventing gum and gum diseases.
  • the agent according to the invention without propellant gas at 25 ° C has a viscosity of at least 10,000 mPa-s (Brookfield rotational viscometer RVF, spindle 3 or 4 at 4rpm), which ensures the dimensional stability after removal of the agent from the dispenser, d. H. in particular prevents flow.
  • the agent can directly, e.g. B. be applied with a toothbrush, but is also particularly suitable as a mouthwash when diluted with water, since the fine foam is very easily dispersible in water.
  • compositions according to the invention can be filled together with the propellant gas using commercially available filling systems through the valve head opening of the dispenser, it is advantageous that the viscosity of the agent without propellant gas at 25 ° C is not higher than 100,000 mPa-s, with a range of 10,000 - 80,000 mPa-s and in particular between 10,000 and 50,000 mPa-s is preferred (Brookfield rotational viscometer RVF, spindle 3 - 5 at 4rpm).
  • Another object of the invention is a method for dental care and cleaning, characterized in that from a dispenser system, by manually actuating a valve, a toothpaste strand that is not or only slightly foamed is applied to an object suitable for mechanical cleaning of the teeth, the toothpaste strand at 20 ° C and normal pressure has an expansion rate of not more than 100% by volume in 5 seconds and then expands to not more than 6 times its volume in a period of 10-100 seconds, and the gas-containing tooth pasta mousse used to clean the tooth surfaces, interdental spaces and the oral cavity.
  • Water-insoluble inorganic substances are usually used as polishing agents, cleaning agents or abrasives, which mechanically remove the plaque without damaging the enamel or dentin.
  • polishing agents cleaning agents or abrasives, which mechanically remove the plaque without damaging the enamel or dentin.
  • the polishing agent is used in the compositions according to the invention in an amount of 5 to 50% by weight, preferably 8 to 30% by weight and in particular 10 to 20% by weight, based on the total composition. It is often particularly advantageous to use a combination of polishing agents.
  • water-insoluble metaphosphates such as z. B. sodium metaphosphate, calcium phosphates such. B. tricalcium phosphate, calcium hydrogen phosphate, calcium hydrogen phosphate dihydrate and calcium pyrophosphate, calcium carbonate (chalk), magnesium carbonate, magnesium dihydrogen phosphate, trimagnesium phosphate, aluminum oxide, calcined aluminum oxide, aluminum hydroxide and aluminum oxide hydrates, hydroxyapatite and various silicates.
  • Sodium bicarbonate can also be used as a polishing agent according to the invention, in particular in a mixture with other polishing agents.
  • the composition preferably contains at least one compound from the group of silicas or silicates as the polishing agent.
  • silicic acid polishing agents precipitated and gel silicic acids are preferred because their properties can be varied widely during manufacture and are particularly well tolerated with fluoride active substances. They are also particularly suitable for the production of gel or liquid toothpastes.
  • Gel silicas are produced by reacting sodium silicate solutions with strong aqueous mineral acids to form a hydrosol, aging to the hydrogel, washing and subsequent drying. If drying is carried out under gentle conditions to water contents of 15-35% by weight, so-called hydrogel silicas are obtained, as are known, for example, from US Pat. No. 4,153,680.
  • xerogel silicas are e.g. B. described in US 3,538,230.
  • Precipitated silicas are produced from aqueous alkali silicate solutions by precipitation with mineral acids and under conditions in which aggregation to form sol and gel cannot occur.
  • Suitable processes for the preparation of precipitated silicas are e.g. B. in DE-OS 25 22 486 and described in DE-OS 31 14 493.
  • suitable silica abrasives include, for example, under the name ® Sident 8, Zeodent ® 113 and 623, Sorbosil AC39 ®, Tixosü ® 123 and 73 commercially.
  • polishes among the silicates.
  • Sodium aluminum silicates can also be suitable as polishing agents, such as. B. synthetic zeolites, in particular zeolite A.
  • Particulate organic polymers e.g. B. polymethacrylate or polyethylene and polypropylene an average particle size of about 5 - 15 microns and an average molecular weight of 3000 g / mol can be used as a cleaning body.
  • Moisturizers are not only added to toothpastes to protect them from drying out, they also serve to provide consistency and low-temperature stability.
  • a moist holding agents can be used toxicologically harmless polyols, such as. B. sorbitol, xylitol, glycerin, mannitol, 1,2-propylene glycol or mixtures of these polyols.
  • Polyethylene glycols with molecular weights of 400-2000 can also be present in part as humectant components.
  • the agent according to the invention contains at least sorbitol, glycerol or xylitol or any mixture of these substances as a humectant.
  • the total composition contains the humectant or the mixture of humectants in an amount of 15-85% by weight, preferably 20-70% by weight and in particular 30-50% by weight.
  • the composition according to the invention preferably contains a mixture of humectants, in particular with a proportion of sorbitol / polyethylene glycol in a weight ratio of 10: (0.1-1).
  • a further improvement in the cleaning effect of the tooth cleaning agents according to the invention is achieved by adding a suitable surface-active surfactant or surfactant mixture.
  • a suitable surface-active surfactant or surfactant mixture A detailed list of suitable surfactants is given in U.S. 3,988,433 which are intended to be part of the disclosure of the present application.
  • the addition of surfactants also serves to generate a foam when brushing teeth and thus to better distribute active ingredients, to stabilize the polishing agent and propellant gas dispersion and to emulsify or solubilize the fats, oils, waxes and aroma oils.
  • the surfactant or surfactant mixture is used in the compositions according to the invention in an amount of 0.1-10% by weight, preferably 0.3-7% and in particular 1-5% by weight, based on the total composition.
  • the composition preferably contains a surfactant from the group of anionic surfactants, zwitterionic surfactants, amphoteric surfactants and nonionic surfactants or any mixture of these sur
  • Suitable surfactants with good foaming action are anionic surfactants, which also have a certain enzyme-inhibiting effect on the bacterial metabolism of the plaque. ben.
  • anionic surfactants include alkali or ammonium salts - in particular sodium salts of C 8 -C 8 -alkane carboxylic acids, of alkyl polyglycol ether sulfates with 12-16 C atoms in the linear alkyl group and 2-6 glycol ether groups in the molecule, of linear alkane (C ⁇ -C 18 ) sulfonates, sulfosuccinic acid monoalkyl (C 12 -C 18 ) esters, sulfated fatty acid monoglycerides, sulfated fatty acid alkanolamides, sulfoacetic acid alkyl (C 12 -C 16 ) esters, acyl sarcosines, acyl taurides and acyl isethionates each with 8
  • At least one anionic surfactant in particular a sodium alkyl sulfate with 12-18 C atoms in the alkyl group.
  • a surfactant is sodium lauryl sulfate which is, for example, under the name Texapon.RTM ® K1296 commercially.
  • Zwitterionic and ampholytic surfactants can also be used, preferably in combination with anionic surfactants.
  • the amphoteric surfactants which can be used according to the invention include, for. B. alkylaminopropane carboxylic acid.
  • the best known and most widespread group of zwitterionic surfactants is that of betaine surfactants, such as. B. alkyldimethylcarboxymethylbetaine and acylaminoalkyldimethylcarboxymethylbetaine. Cocosacylaminopropyldimethylammonium glycinates, known under the INCI name Cocamidopropylbetaine, are particularly suitable.
  • Such products are commercially available, for example, under the name Tego-Betain ® BL 215 and ZF 50 and Genagen ® CAB.
  • Non-ionic surfactants are particularly suitable for supporting the cleaning action, among which the addition products of ethylene oxide with fatty alcohols, with fatty acids, with fatty acid monoglycerides, with sorbitan fatty acid monoesters or with methyl glucoside fatty acid monoesters are preferred.
  • the amount of ethylene oxide added should be so high that the surfactants are water-soluble, ie at least 1 g of the product should be clearly soluble in 11 water at 20 ° C.
  • nonionic Surfactants are ethoxylated glyceryl monoalkyl esters with a degree of ethoxylation of 20-60 and a C 8 -C 18 alkyl chain, such as, for example, PEG-30 glyceryl stearate, which, for. B. is commercially available under the name Tagat ® S, and also acts as a solubilizer.
  • Suitable nonionic surfactants are also alkyl (oligo) glycosides with 8-16 carbon atoms in the alkyl group and a degree of oligomerization of the glycoside residue of 1-4 alkyl (oligo) glycosides.
  • Their preparation and use as surface-active substances are e.g. , B. from US-A-3,839,318, DE-A-20 36 472, EP-A-77 167 or WO-A-93/10132 known.
  • the degree of oligomerization is a statistical mean value which is based on a homolog distribution customary for such technical products.
  • an alkyl group suitable alkyl (oligo) glycoside is an alkyl (oligo) glucoside of the formula RO (C 6 H, 0 O) X -H, in which R 12 to 14 carbon atoms and x is a Has mean of 1 to 4.
  • Amine oxides can also be used as surfactants.
  • a mixture of anionic and nonionic surfactant or a mixture of anionic surfactant, nonionic surfactant and betaine is preferably used in the compositions according to the invention, for example sodium lauryl sulfate / PEG-30 glyceryl stearate / cocamidopropyl.
  • non-ionic solubilizers from the group of surface-active substances are used to improve the solubilization of the predominantly water-insoluble oil and wax components and the propellant gases.
  • these include in particular ethoxylated compounds with a degree of ethoxylation of 20-60.
  • Ethoxylated fatty acid glycerides, ethoxylated fatty acid sorbitan partial esters or fatty acid partial esters of glycerol or sorbitan ethoxylates are particularly suitable for this purpose.
  • Solubilizers from the group of ethoxylated fatty acid gly- cerides primarily include adducts of 20 to 60 moles of ethylene oxide with mono- and diglycerides of linear fatty acids with 12 to 18 carbon atoms or with triglycerides of hydroxy fatty acids such as oxystearic acid or ricinoleic acid.
  • Other suitable solubilizers are ethoxylated fatty acid sorbitan partial esters, e.g. B. Adducts of 20 to 60 moles of ethylene oxide with sorbitan monoesters and sorbitan diesters of fatty acids with 12 to 18 carbon atoms.
  • solubilizers are fatty acid partial esters of glycerol or sorbitan ethoxylates; the preferred are mono- and diesters of C I2 - C 18 fatty acids and addition products of 20 to 60 moles of ethylene oxide with 1 mole of glycerol or with 1 mol of sorbitol.
  • alkyl-trimethylammonium chloride alkyldimethylbenzylammonium chloride, alkylpyridinium chloride, alkyldimethylhyroxyethylammonium chloride, acylimidazolinium methosulfates and acyloxyethyltrimethylammonium chloride are suitable as surfactants in the agents according to the invention.
  • the oil fat and wax components are essential components of the composition according to the invention. In combination with the surfactants, they enable partial solubilization of the propellant gas or propellant gas mixture, stabilization of the foam and give the toothpaste base composition shine and smoothness.
  • natural, chemically modified and synthetic waxes, fats and oils can be used alone or in any combination.
  • the oil / fat and wax components are present in an amount of 0.1 to 10% by weight, based on the total composition, preferably 0.5 to 5% by weight and in particular 0.8 to 3% by weight. Oils / fats
  • the compositions of the invention comprise, as oil components triglycerides and / or a paraffin oil. These can be of vegetable, animal or synthetic origin.
  • Di- and triglycerides are the di- and triester of fatty acids with glycerin, ie acylglycerols, whereby the glycerin can be esterified with the same or with different fatty acids or fatty acid derivatives (eg lecithin).
  • the fatty acids are preferably C 6 -C 30 fatty acids, which can be saturated or unsaturated and branched or unbranched.
  • glycerol with naturally occurring fatty acids such as, for example, caproic acid, oenanthic acid, caprylic acid, pelargonic acid, capric acid, undecanoic acid, lauric acid, tridecanoic acid, myristic acid, pentadecanoic acid, palmitic acid, margaric acid, stearic acid, nonadecanoic acid, arenic acid, arachinic acid , Lignoceric acid, cerotinic acid, melissic acid, 2-ethylhexanoic acid, isotridecanoic acid, isostearic acid, palmitoleic acid, oleic acid, elaidic acid, petroselinic acid, elaeostearic acid, erucic acid, linoleic acid, linolenic acid, arachidonic acid, clupanodonic acid and technical blends, docosaoleic acid and doco
  • natural fats and oils such as e.g. B. beef tallow, peanut oil, rape oil, cottonseed oil, soybean oil, sunflower oil, palm oil, palm kernel oil, linseed oil, almond oil, castor oil, corn oil, olive oil, rapeseed oil, sesame oil, cocoa butter and coconut oil and the like.
  • the hydrogenated or hardened oils e.g. B. hydrogenated soybean oil, castor oil and peanut oil can be used.
  • Thin to viscous silicone oils or natural and synthetic hydrocarbons such as thin to viscous paraffin can also be used according to the invention.
  • oils, isohexadecane, isoeicosane or polydecenes, e.g. B. are available under the name Emery ® 3004, 3006, 3010, Ethylflo ® or Nexbase ® 2004G.
  • inverse fats e.g. esters of vicinal tricarboxylic acids with C 6 -C 30 fatty alcohols
  • glyceryl trialkyethers is also conceivable here.
  • Waxes are understood to mean naturally or artificially obtained substances with the following properties: they have a firm to fragile hard consistency, coarse to fine crystalline, translucent to opaque, but not glassy, and melt without decomposition above 35 ° C. They are low viscosity and not stringy a little above the melting point and show a strongly temperature-dependent consistency and solubility. From a chemical point of view, the most common representatives from the wax group are esters from fatty acids and higher fatty alcohols, which are of animal and vegetable origin. Natural vegetable waxes, such as, for example, B.
  • the mineral waxes that can be used according to the invention also include the mineral waxes, such as. B.
  • waxes such as paraffin waxes (z. B. Vaseline) and micro waxes.
  • paraffin waxes z. B. Vaseline
  • micro waxes z. B. Vaseline
  • chemically modified waxes such as. B. Montanester waxes, Sasol waxes and hydrogenated jojoba waxes can be used.
  • the synthetic waxes which can be used according to the invention also include, for example, wax-like polyalkylene waxes and silicone waxes.
  • Synthetic waxes can also be used according to the invention, in particular the esters of C 6 -C 30 fatty acids with C 6 -C 30 fatty alcohols, which can be of natural or synthetic origin. Both the fatty acid component and the fatty alcohol component can be straight-chain or branched and saturated or mono- or polyunsaturated.
  • the wax component is preferably selected from the group of vegetable or animal and / or paraffin waxes or any mixture of these waxes.
  • the propellant gas or propellant gas mixture is preferably present in the compositions according to the invention in an amount of at least 1% by weight. A content of 1-10% by weight and in particular 3-4% by weight is particularly preferred.
  • the propellant gas or propellant mixture preferably contains at least one component which has a boiling point in the range from 0 to 40 ° C., preferably 15 to 35 ° C. and in particular 20 to 30 ° C. at normal pressure. In this way, a "post-foaming" effect can be produced in combination with the dispenser systems described below, hydrocarbon-containing propellants being particularly advantageous.
  • the propellant preferably contains a C 5 alkane.
  • Such formulations are still gel-like immediately after being dispensed from the dispenser and then swell gradually on the toothbrush to form a foam which is particularly at body temperature, that is, when the composition is applied inside the mouth, unfolds relatively quickly.
  • the tooth cleaning agents are filled in commercial filling systems together with the liquefied propellant gas or propellant gas mixture into dispenser systems which are sufficiently pressure-resistant that the propellant gas is liquefied in the composition.
  • a container for example, is suitable as a dispenser for the composition with valve made of a rigid material, which is equipped with a device which uses the contraction force of a stretched rubber hose and / or a stretched product container to eject the composition stored therein (i.e. dentifrice and propellant).
  • a dispenser is described for example in EP 69699.
  • the containers offered by 3D Dispenser-Distributions GmbH under the name FlexPack ® also use the restoring force of a stretched rubber to eject the composition.
  • containers which contain a folded, essentially gas-impermeable flexible inner bag made of a chemically inert plastic (for example PET) which is surrounded by an elastic, thick-walled rubber tube.
  • a chemically inert plastic for example PET
  • Such dispensers are described for example in US 5,927,551, US 4,964,540 and EP 69738 and are sold by the Exxel Container company under the name Atmos TM Dispensing System. In combination with such dispensers, pure butane as the propellant gas can already produce a "post-foaming" effect.
  • two-chamber aerosol cans with inner bags are preferably suitable as dispensers. These contain the contents (tooth cleaning agent with liquefied gas) in the inner bag and a further propellant gas in the outer chamber, which serves to expel the composition when the valve is actuated.
  • Such systems can either be filled through an opening in the bottom of the can or - as in the so-called "under cup system” - by lifting the valve.
  • the agent according to the invention additionally contains at least one binding or thickening agent.
  • Binding agents or thickeners have a consistency-regulating effect and help to prevent separation of the liquid and solid components. They are contained in the compositions according to the invention in a total amount of 0.1-5% by weight, preferably 0.1-3% by weight and in particular 0.5-2% by weight.
  • natural and / or synthetic water-soluble polymers such as alginates, carragenes, agar-agar, guar-gum, rubber are used arabicum, succinoglycan gum, guar flour, locust bean gum, tragacanth, karaya gum, xanthan, pectins, cellulose and their ionogenic and non-ionogenic derivatives such as B. carboxymethyl cellulose, hydroxyethyl cellulose or methyl hydroxypropyl cellulose, hydrophobically modified celluloses, starch and starch ethers.
  • natural and / or synthetic water-soluble polymers such as alginates, carragenes, agar-agar, guar-gum, rubber are used arabicum, succinoglycan gum, guar flour, locust bean gum, tragacanth, karaya gum, xanthan, pectins, cellulose and their ionogenic and non-ionogenic derivatives such as B. carboxymethyl
  • carboxyvinyl polymers for example Carbopol ® grades.
  • Polyvinyl alcohol, polyvinylpyrrolidone and high molecular weight polyethylene glycols are useful as binders and thickeners.
  • Layered silicates and finely divided silicas airgel silicas and pyrogenic silicas
  • Particularly suitable is powdered cellulose, which is offered for example, from J. Rettenmaier & Söhne under the name of Arbocel ® or Vitacel ®.
  • Arbocel ® CGP 5000 a highly viscous paste made of powder cellulose with thixotropic properties, is particularly preferably suitable according to the invention.
  • Arbocel ® celluloses are extremely effective thickeners, which increase the viscosity of the compositions considerably even at low use concentrations, are inert to ionic components and can be easily combined with other thickeners.
  • a further preferred embodiment of the tooth cleaning agent is characterized in that it contains anti-caries agents, antimicrobial agents, tartar inhibitors, remineralizing agents, flavoring agents or any combination of these substances as additional agents.
  • fluorine compounds are particularly suitable, preferably from the group of fluorides or monofluorophosphates in an amount of 0.1-0.5% by weight of fluorine.
  • Suitable fluorine compounds are e.g. As sodium fluoride, potassium fluoride, tin fluoride, disodium monofluorophosphate (Na 2 PO 3 F), dipotassium monofluorophosphate or the fluoride of an organic amino compound.
  • Antimicrobial agents are e.g. As sodium fluoride, potassium fluoride, tin fluoride, disodium monofluorophosphate (Na 2 PO 3 F), dipotassium monofluorophosphate or the fluoride of an organic amino compound.
  • antimicrobial component examples include, for. B. phenols, resorcinols, bisphenols, salicylanilides and amides and their halogenated derivatives, halogenated carbanilides and p-hydroxybenzoic acid esters.
  • antimicrobial components those which inhibit the growth of plaque bacteria are particularly suitable.
  • halogenated diphenyl ethers such as 2,4-dichloro-2'-hydroxydiphenyl ether, 4,4'-dichloro-2'-hydroxy diphenyl ether, 2,4,4 '-tribromo-2'-hydroxy diphenyl ether, 2,4,4 '-Trichlor-2' - hydroxydiphenyl ether (triclosan) suitable as antimicrobial agents.
  • bisbiguanides such as chlorhexidine and alexidine, phenylsalicylic acid esters and 5-amino-1,3-bis (2-ethylhexyl) hexahydro-5-methylpyrimidine (hexetidine)
  • zinc and copper ions also have an antimicrobial effect, with synergistic effects in particular in combination occur with hexetidine and triclosan.
  • Quaternary ammonium compounds such as. B. cetylpyridinium chloride, benzalkonium chloride, domiphen bromide and dequalinium chloride can be used.
  • Octapinol, octenidines and sanguinarine have also proven to be antimicrobial.
  • the antimicrobial active ingredients are preferably used in amounts of 0.01-1% by weight in the agents according to the invention and can also be used in the form of nanoparticles.
  • Irgacare ® MP is particularly preferred in an amount from 0.01 to 0.3 wt .-% is used.
  • Tartar is mineral deposits that are very similar to natural tooth enamel.
  • substances are added to the tooth cleaning agents according to the invention which specifically intervene in the crystal nucleation and prevent existing germs from continuing to grow.
  • These are, for example, condensed phosphates, which are preferably selected from the group of tripolyphosphates, pyrophophates, trimetaphosphates or mixtures thereof. They are used in the form of their alkali or ammonium salts, preferably in the form of their sodium or potassium salts.
  • Aqueous solutions of these phosphates typically have an alkaline reaction, so that the pH of the dentifrices according to the invention is adjusted to values of 7.5-9, if necessary by adding acid.
  • acids z. B.
  • citric acid, phosphoric acid or acid salts e.g. B. NaH 2 PO 4 can be used.
  • the desired pH of the dentifrice can also be achieved by adding acidic salts of the condensed phosphates, e.g. B. K 2 H 2 P 2 O 7 can be set.
  • Tartar inhibitors are usually used in amounts of 0.1-5% by weight, preferably 0.1-3% by weight and in particular 0.1-2% by weight in the agents according to the invention.
  • organophosphonates such as 1-azacycloheptane-2,2-diphosphonate (Na salt) or 1-hydroxyethane-1, 1-diphosphonate (Na salt) and zinc citrate.
  • the agents according to the invention preferably also contain substances which promote remineralization of the tooth enamel and are able to close dental lesions. These are usually contained in a total amount of 0.1-10% by weight, preferably 0.1-5% by weight and in particular 0.1-3% by weight. These include e.g. B. fluorides, phosphate salts of calcium such. As calcium glycerol phosphates, calcium hydrogen phosphate, hydroxyapatite, fluoroapatite, F-doped hydroxyapatite, dicalcium phosphate dihydrate and calcium fluoride. But also magnesium salts such as. B. magnesium sulfate, magnesium fluoride or magnesium monofluorophosphate have a remineralizing effect.
  • the agents according to the invention preferably contain flavorings, to which e.g. B. sweeteners and / or aromatic oils.
  • suitable sweeteners are saccharinates (in particular sodium saccharinate), cyclamates (in particular sodium cyclamate) and sucrose, lactose, maltose or fructose.
  • Aromatic oils that can be used are all natural and synthetic aromas that are common for oral and dental care products. Natural aromas can be used both in the form of the essential oils (mixture) isolated from the drugs and in the form of the individual components isolated from them.
  • At least one aromatic oil from the group peppermint oil, Spearmint oil, anise oil, star anise oil, caraway oil, eucalyptus oil, fennel oil, cinnamon oil, clove oil, geranium oil, sage oil, allspice oil, thyme oil, marjoram oil, basil oil, citrus oil, Gaultheria oil or one / more components of these oils isolated or synthetically produced.
  • aromatic oil from the group peppermint oil, Spearmint oil, anise oil, star anise oil, caraway oil, eucalyptus oil, fennel oil, cinnamon oil, clove oil, geranium oil, sage oil, allspice oil, thyme oil, marjoram oil, basil oil, citrus oil, Gaultheria oil or one / more components of these oils isolated or synthetically produced.
  • the most important components of the oils mentioned are e.g. B.
  • menthol carvone, anethole, cineol, eugenol, cinnamaldehyde, caryophyllene, geraniol, citronellol, linalool, salvos, thymol, terpinene, terpinol, methylchavicol and methyl salicylate.
  • suitable flavors are e.g. B. menthyl acetate, vanillin, jonone, linalyl acetate, rhodinol and piperiton.
  • a particularly preferred embodiment of the tooth cleaning agent contains a) 5-30% by weight of a polishing agent; b) 20-85% by weight of a humectant; c) 0.3-5% by weight of a surfactant or surfactant mixture; d) 0.1-40% by weight of an oil, fat and / or wax, e) 0.05-0.5% by weight of a fluoride; f) 5-50% by weight of water g) 1-10% by weight of a C 4 and / or C 5 -containing propellant gas or propellant gas mixture and in a dispenser system with a manually operable valve.
  • This combination enables a particularly good post-foaming effect and very easy distribution.
  • the agent according to the invention can preferably contain a number of further toothpaste ingredients. These include a .:
  • Vitamins e.g. B. retinol, biotin, tocopherol, ascorbic acid and their derivatives (e.g. esters, salts);
  • pigments e.g. B. titanium dioxide or zinc oxide
  • pH adjusting agents and buffer substances e.g. B. sodium citrate, sodium bicarbonate or potassium and sodium phosphates,
  • the dentifrice was prepared with degassing, i.e. H. in a moderate vacuum ( ⁇ 50 mbar), at room temperature.
  • the humectants, silicas and possibly other polishing agents were homogenized together with demineralized water in a vacuum with stirring.
  • the soluble salts and dyes were then added.
  • Cellulose - if used - was suspended in a little water and worked into the mass.
  • Organic binders e.g. xanthan gum etc.
  • the paste mass (90-99% by weight) was placed together with 1-10% by weight of the propellant gas / propellant gas mixture in the Atmos TM dispensing system (70 or 140 ml) from Exxel Container Inc. or in a two-chamber aerosol can bottled under the usual conditions for such systems (filling pressure: approx. 40 bar).
  • Example 1 composition without propellant
  • silica e.g. Sident ® 8
  • sorbitol e.g. Neosorb ® 70/70 B; 70% by weight in water
  • sodium lauryl sulfate e.g. Texapon ® K 1296
  • cocamidopropylbetaine e.g. Tego-Betain ® BL 215; 30% by weight in water
  • PEG-30 glyceryl stearate e.g. Tagat ® S
  • beeswax e.g. beeswax type 8100 DAB
  • polyethylene glycol MG 1550 (e.g. Polywachs ® 1550)
  • carboxymethyl cellulose e.g. Cekol ® 2000 H
  • triclosan e.g. Irgacare ® MP
  • dye solution e.g. Brillant Blue FCF, 1% by weight in water
  • silica e.g. Sident ® 8
  • sorbitol e.g. Neosorb ® 70/70 B; 70% by weight in water
  • sodium lauryl sulfate e.g. Texapon ® K 1296
  • cocamidopropyl betaine e.g. Tego-Betain ® BL 215, 30% by weight in water
  • PEG-30 glyceryl stearate e.g. Tagat ® S
  • paraffin oil 1.0% by weight paraffin oil, low viscosity (e.g. Paraffinum perliquidum P 130)
  • polyethylene glycol MG 1550 (e.g. Polywachs ® 1550)
  • xanthan gum e.g. Keltrol ® F
  • triclosan e.g. Irgacare ® MP
  • dye solution e.g. brilliant blue FCF, 1% by weight in water
  • silica e.g. Sident ® 8
  • sorbitol e.g. Neosorb ® 70/70 B; 70% by weight in water
  • sodium lauryl sulfate e.g. Texapon ® K 1296
  • cocamidopropylbetaine e.g. Tego-Betain ® BL 215; 30% by weight in water
  • PEG-30 glyceryl stearate e.g. Tagat ® S
  • beeswax e.g. beeswax type 8100 DAB
  • polyethylene glycol MG 1550 (e.g. Polywachs ® 1550)
  • carboxymethyl cellulose e.g. Cekol ® 2000 H
  • triclosan e.g. Irgacare ® MP
  • dye solution e.g. Brillant Blue FCF, 1% by weight in water
  • silica e.g. Sident ® 8
  • sorbitol e.g. Neosorb ® 70/70 B; 70% by weight in water
  • sodium lauryl sulfate e.g. Texapon ® K 1296
  • cocamidopropylbetaine e.g. Tego-Betain ® BL 215; 30% by weight in water
  • PEG-30 glyceryl stearate e.g. Tagat ® S
  • paraffin oil e.g. Paraffinum perliquidum P 130
  • polyethylene glycol MG 1550 (e.g. Polywachs ® 1550)
  • xanthan gum e.g. Keltrol ® F
  • triclosan e.g. Irgacare ® MP
  • dye solution e.g. Brillant Blue FCF, 1% by weight in water
  • silica e.g. Sident ® 8
  • sorbitol e.g. Neosorb ® 70/70 B; 70% by weight in water
  • sodium lauryl sulfate e.g. Texapon ® K 1296
  • cocamidopropylbetaine e.g. Tego-Betain ® BL 215; 30% by weight in water
  • PEG-30 glyceryl stearate e.g. Tagat ® S
  • polyethylene glycol MG 1550 (e.g. Polywachs ® 1550)
  • xanthan gum e.g. Keltrol ® F
  • triclosan e.g. Irgacare ® MP
  • dye solution e.g. Brillant Blue FCF, 1% by weight in water
  • silica e.g. Sident ® 8
  • sorbitol e.g. Neosorb ® 70/70 B; 70% by weight in water
  • sodium lauryl sulfate e.g. Texapon ® K 1296
  • cocamidopropylbetaine e.g. Tego-Betain ® BL 215; 30% by weight in water
  • PEG-30 glyceryl stearate e.g. Tagat ® S
  • paraffin oil e.g. BP-Energol ® WM-6
  • viscous e.g. BP-Energol ® WM-6
  • polyethylene glycol MG 1550 (e.g. Polywachs ® 1550)
  • carboxymethyl cellulose e.g. Cekol ® 2000H
  • triclosan e.g. Irgacare ® MP
  • dye solution e.g. brilliant blue FCF, 1% by weight in water
  • silica e.g. Sident ® 8
  • sorbitol e.g. Neosorb ® 70/70 B; 70% by weight in water
  • sodium lauryl sulfate e.g. Texapon ® K 1296
  • cocamidopropylbetaine e.g. Tego-Betain ® BL 215; 30% by weight in water
  • PEG-30 glyceryl stearate e.g. Tagat ® S
  • paraffin oil e.g. BP-Energol ® WM-6
  • viscous e.g. BP-Energol ® WM-6
  • glycerol monostearate e.g. Cutina ® GMS-V
  • polyethylene glycol MG 1550 (e.g. Polywachs ® 1550)
  • xanthan gum e.g. Keltrol ® F
  • triclosan e.g. Irgacare ® MP
  • dye solution e.g. Brillant Blue FCF, 1% by weight in water
  • silica e.g. Sident ® 8
  • sorbitol e.g. Neosorb ® 70/70 B; 70% by weight in water
  • sodium lauryl sulfate e.g. Texapon ® K 1296
  • cocamidopropylbetaine e.g. Tego-Betain ® BL 215; 30% by weight in water
  • PEG-30 glyceryl stearate e.g. Tagat ® S
  • paraffin oil e.g. BP-Energol ® WM-6
  • viscous e.g. BP-Energol ® WM-6
  • glycerol monostearate e.g. Cutina ® GMS-V
  • polyethylene glycol MG 1550 (e.g. Polywachs ® 1550)
  • xanthan gum e.g. Keltrol ® F
  • triclosan e.g. Irgacare ® MP
  • dye solution e.g. Brillant Blue FCF, 1% by weight in water
  • Süica e.g. Sident ® 8
  • sorbitol e.g. Neosorb ® 70/70 B; 70% by weight in water
  • sodium lauryl sulfate e.g. Texapon ® K 1296
  • cocamidopropylbetaine e.g. Tego-Betain ® BL 215; 30% by weight in water
  • PEG-30 glyceryl stearate e.g. Tagat ® S
  • polyethylene glycol MG 1550 (e.g. Polywachs ® 1550)
  • cellulose e.g. Arbocel ® CGP 5000; 5% by weight in water
  • xanthan gum e.g. Keltrol ® F
  • triclosan e.g. Irgacare ® MP
  • dye solution e.g. combination of: Brillant Blue FCF, 1% by weight in
  • Example 10 composition without propellant
  • silica e.g. Sident ® 8
  • layered silicate e.g. Laponite ® DF
  • sorbitol e.g. Neosorb ® 70/70 B; 70% by weight in water
  • sodium lauryl sulfate e.g. Texapon ® K 1296
  • cocamidopropylbetaine e.g. Tego-Betain ® BL 215; 30% by weight in water
  • PEG-30 glyceryl stearate e.g. Tagat ® S
  • polyethylene glycol MG 1550 (e.g. Polywachs ® 1550)
  • xanthan gum e.g. Keltrol ® F
  • triclosan e.g. Irgacare ® MP
  • dye solution e.g. combination of: Brillant Blue FCF, 1% by weight in
  • silica e.g. Sident ® 8
  • sorbitol e.g. Neosorb ® 70/70 B; 70% by weight in water
  • sodium lauryl sulfate e.g. Texapon ® K 1296
  • cocamidopropylbetaine e.g. Tego-Betain ® BL 215; 30% by weight in water
  • PEG-30 glyceryl stearate e.g. Tagat ® S
  • cellulose e.g. Arbocel ® CGP 5000; 5% by weight in water
  • xanthan gum e.g. Keltrol ® F
  • polyethylene glycol MG 1550 (e.g. Polywachs ® 1550)
  • triclosan e.g. Irgacare ® MP
  • dye solution e.g. combination of: Brillant Blue FCF, 1% by weight in

Abstract

The invention relates to dental cleaning agents containing polishing agents, humectants and tensides combined with liquid oils or wax components, which are fed into a dispenser system with propellant gases, said dispenser system having a valve.

Description

"Treibgashaltiges Zahnreinigungsmittel" "Dental cleaning agent containing propellant gas"
Die Erfindung betrifft ein treibgashaltiges Zahnreinigungs- und Pflegemittel in einem Spendersystem, welches bei Betätigung eines Ventils als Pasten- oder Gelstrang abgegeben wird und danach durch Freisetzung des Treibgases langsam aufquillt und einen feinblasigen, stabilen Schaum entwickelt.The invention relates to a propellant-containing tooth cleaning and care agent in a dispenser system, which is released as a paste or gel strand when a valve is actuated and then swells slowly through the release of the propellant gas and develops a fine-bubble, stable foam.
Zahnreinigungsmittel sind in verschiedenen Formen auf dem Markt und dienen in erster Linie der Reinigung der Zahnoberflache ; und der Vorbeugung von Zahn- und Zahnfleischerkrankungen. Sie enthalten üblicherweise eine Kombination aus Poliermitteln, Feuchthaltemitteln, Tensiden, Bindemitteln, Aromastoffen und fluoridhaltigen sowie anti- mikrobiellen Wirkstoffen. Neben Zahnpulvern, die wegen ihrer erhöhten Abrasivität eine untergeordnete Rolle spielen, werden Zahnreinigungsmittel vor allem in Pasten-, Creme- und transluzenter oder transparenter Gelform angeboten. In den letzten Jahren haben auch Liquid- oder Flüssigzahncremes und Mundwässer zunehmend an Bedeutung gewonnen. Ein Nachteil der Produkte in Pasten-, Creme- oder Gelform ist deren vergleichsweise hohe Viskosität und dadurch bedingte schlechte Verteilbarkeit und langsame Freisetzung der Wirk- und Aromastoffe.Tooth cleaning agents are available in various forms and primarily serve to clean the tooth surface ; and prevention of tooth and gum disease. They usually contain a combination of polishing agents, humectants, surfactants, binders, flavorings and fluoride-containing and anti-microbial agents. In addition to tooth powders, which play a subordinate role due to their increased abrasiveness, tooth cleaning agents are mainly offered in paste, cream and translucent or transparent gel form. In recent years, liquid or liquid toothpastes and mouthwashes have also become increasingly important. A disadvantage of the products in paste, cream or gel form is their comparatively high viscosity and the resulting poor spreadability and slow release of the active ingredients and flavorings.
Eine verbesserte Verteilbarkeit erreicht man durch aufgeschäumte Zahncremes, die üblicherweise aus Aerosolspendern abgegeben werden. Derartige Formulierungen sind aus der WO 99/22704, WO 82/03975, EP 0 208 009, AU 8542824, DE 2 217 953, DE 36 23 934, JP 5714520 A und der JP 5714521 A bekannt. Als Treibgase werden FCKW's, Kohlendioxid, Sauerstoff und niedrigsiedende Kohlenwasserstoffe eingesetzt. Der Einsatz von Fluor-Chlor-Kohlenwasserstoffen (FCKWs) ist wegen ihrer ökologischen Bedenklichkeit in vielen Ländern jedoch nicht mehr erlaubt. Generell handelt es sich bei Zahnpastaschäumen um Emulsionen oder Dispersionen, die aus den Spendern in bereits aufgeschäumter Form abgegeben werden. Dies hat den Nachteil, daß die Wirkstoffmenge oft viel zu niedrig ist. Derartige Zahnpastaschäume sind meist nur über kurze Zeit stabil. Darüber hinaus sind reine Kohlenwasserstofftreibgase mit den üblichen Zahnpastaformu- lierungen meist nicht kompatibel, da sie in diesen unlöslich sind, so daß es zu einer Phasentrennung kommt.Foamed toothpastes, which are usually dispensed from aerosol dispensers, improve the spreadability. Such formulations are known from WO 99/22704, WO 82/03975, EP 0 208 009, AU 8542824, DE 2 217 953, DE 36 23 934, JP 5714520 A and JP 5714521 A. CFCs, carbon dioxide, oxygen and low-boiling hydrocarbons are used as propellants. However, the use of fluorine-chlorine hydrocarbons (CFCs) is no longer permitted in many countries due to their ecological concern. In general, toothpaste foams are emulsions or dispersions that are released from the dispensers in an already foamed form. This has the disadvantage that the amount of active ingredient is often far too low. Such toothpaste foams are usually only stable for a short time. In addition, pure hydrocarbon propellants with the usual toothpaste form Mostly not compatible because they are insoluble in them, so that there is a phase separation.
Aufgabe war es daher, ein Zahnreinigungs- und Pflegemittel mit verbesserter Verteilbarkeit zu entwickeln, das zunächst als nicht oder nur gering aufgeschäumter, gelartiger Strang aus einem Spender abgegeben wird und dann allmählich - insbesondere bei Applikation im Mund - einen mousseartigen, „prickelnden" Schaum mit völlig neuartiger Sen- sorik und intensivierter Aromafreisetzung ausbildet. Eine weitere Aufgabe bestand darin, die Zusammensetzung so zu optimieren, daß Treibgas und Zahnpastagrundlage eine stabile Dispersion ausbilden, die sich nicht trennt oder das Leitungssystem des Spenders blockiert.The task was therefore to develop a dentifrice and care product with improved spreadability, which is initially dispensed from a dispenser as a non-foamed or only slightly foamed, and then gradually - especially when applied in the mouth - with a mousse-like, "tingling" foam Another task was to optimize the composition in such a way that the propellant gas and toothpaste base form a stable dispersion that does not separate or blocks the line system of the dispenser.
Diese Aufgabe wurde erfindungsgemäß gelöst durch ein Zahnreinigungsmittel enthaltend a) wenigstens ein Poliermittel b) wenigstens ein Feuchthaltemittel c) wenigstens ein Tensid d) wenigstens eine Öl/Fett- und/oder Wachskomponente dadurch gekennzeichnet, daß es zusammen mit einem Treibgas oder Treibgasgemisch in einem Spendersystem mit manuell betätigbarem Ventil abgefüllt ist.This object was achieved according to the invention by a tooth cleaning agent containing a) at least one polishing agent b) at least one humectant c) at least one surfactant d) at least one oil / fat and / or wax component, characterized in that it is used together with a propellant gas or propellant gas mixture in a dispenser system is filled with a manually operated valve.
Durch die Kombination der Komponenten a) und b) mit Wachs- und/oder Öl-Komponenten sowie Tensiden oder Emulgatoren wird eine stabile Dispersion des Treibgas/Treibgasgemisches in den erfindungsgemäßen Zusammensetzungen ermöglicht. Auch bei längerer Lagerung sind die erfmdungsgemäßen Zusammensetzungen gegen eine Separation des Treibgases/Treibgasgemisches stabil. Eine Blockierung des Leitungssystems des Spenders tritt nicht ein. Die erfindungsgemäße Zusammensetzung wird aus dem Spender in Form eines gelartigen, nicht oder nur wenig aufgeschäumten Stranges abgegeben, der durch allmähliches Entweichen des Treibgas/Treibgasgemisches ein äußerst stabiles, feinblasiges Mousse ausbildet. Dies gewährleistet eine höhere Wirkstoffmenge im Vergleich zu Präparaten, die den Spendern direkt als voluminöser Schaum entnommen werden. Durch die zeitverzögerte Schaumbildung, besonders bei Applikation des Mittels im Mundraum, resultiert jedoch auch eine im Vergleich zu den üblichen Zahnreinigungsmitteln in Creme-, Gel- oder Pastenform verbesserte Verteilbarkeit der Wirkstoffe, eine optimierte Wirkstofffreisetzung sowie eine intensivierte Aromaentfaltung. Der Anteil des Wassers an der erfindungsgemäßen Zusammensetzung beträgt 1 - 60 Gew.-%, vorzugsweise 5 - 50 Gew.-% und insbesondere 30 - 50 Gew.-%. Das Zahnreinigungsmittel weist üblicherweise einen pH- Wert von 5,5 - 9, vorzugsweise 6,5 - 8,0 und insbesondere 7,0 - 7,3 auf.The combination of components a) and b) with wax and / or oil components and surfactants or emulsifiers enables a stable dispersion of the propellant / propellant mixture in the compositions according to the invention. Even when stored for a long time, the compositions according to the invention are stable against separation of the propellant gas / propellant gas mixture. Blockage of the donor's piping does not occur. The composition according to the invention is dispensed from the dispenser in the form of a gel-like, not or only slightly foamed strand which forms an extremely stable, fine-bubble mousse through the gradual escape of the propellant gas / propellant gas mixture. This ensures a higher amount of active ingredient compared to preparations that are taken directly from the donors as voluminous foam. Due to the delayed foaming, especially when applying the agent in the oral cavity, however, this also results in an improved distributability of the active ingredients, an optimized release of active ingredients and an intensified aroma development in comparison to the usual tooth cleaning agents in cream, gel or paste form. The proportion of water in the composition according to the invention is 1-60% by weight, preferably 5-50% by weight and in particular 30-50% by weight. The tooth cleaning agent usually has a pH of 5.5-9, preferably 6.5-8.0 and in particular 7.0-7.3.
Die erfindungsgemäßen Zusammensetzungen sind zur Reinigung und Pflege der Zähne und zur Prävention von Zahn- und Zahnfleischerkrankungen geeignet. Vorzugsweise weist das erfindungsgemäße Mittel ohne Treibgas bei 25 °C eine Viskosität von wenigstens 10000 mPa-s auf (Brookfield Rotationsviskosimeter RVF, Spindel 3 oder 4 bei 4rpm), welche die Formbeständigkeit nach Entnahme des Mittels aus dem Spender gewährleistet, d. h. insbesondere ein Zerfließen verhindert. Das Mittel kann direkt, z. B. mit einer Zahnbürste appliziert werden, eignet sich jedoch bei Verdünnung mit Wasser auch besonders gut als Mundspülung, da der feine Schaum sehr leicht in Wasser dispergierbar ist. Damit die erfmdungsgemäßen Zusammensetzungen zusammen mit dem Treibgas unter Verwendung handelsüblicher Abfüllanlagen durch die Ventilkopföffhung des Spenders abgefüllt werden können, ist es vorteilhaft, daß die Viskosität des Mittels ohne Treibgas bei 25 °C nicht höher als 100000 mPa-s ist, wobei ein Bereich von 10000 - 80000 mPa-s und insbesondere zwischen 10000 und 50000 mPa-s bevorzugt ist (Brookfield Rotationsviskosimeter RVF, Spindel 3 - 5 bei 4rpm).The compositions according to the invention are suitable for cleaning and caring for the teeth and for preventing gum and gum diseases. Preferably, the agent according to the invention without propellant gas at 25 ° C has a viscosity of at least 10,000 mPa-s (Brookfield rotational viscometer RVF, spindle 3 or 4 at 4rpm), which ensures the dimensional stability after removal of the agent from the dispenser, d. H. in particular prevents flow. The agent can directly, e.g. B. be applied with a toothbrush, but is also particularly suitable as a mouthwash when diluted with water, since the fine foam is very easily dispersible in water. So that the compositions according to the invention can be filled together with the propellant gas using commercially available filling systems through the valve head opening of the dispenser, it is advantageous that the viscosity of the agent without propellant gas at 25 ° C is not higher than 100,000 mPa-s, with a range of 10,000 - 80,000 mPa-s and in particular between 10,000 and 50,000 mPa-s is preferred (Brookfield rotational viscometer RVF, spindle 3 - 5 at 4rpm).
Ein weiterer Gegenstand der Erfindung ist ein Verfahren zur Zahnpflege und -reinigung, dadurch gekennzeichnet, daß man aus einem Spendersystem durch manuelle Betätigung eines Ventils einen nicht oder nur wenig aufgeschäumten Zahnpastastrang auf einen zur mechanischen Reinigung der Zähne geeigneten Gegenstand aufbringt, wobei der Zahnpastastrang bei 20 °C und Normaldruck eine Expansionsrate von nicht mehr als 100 Vol.-% in 5 Sekunden aufweist und dann in einer Zeitspanne von 10 - 100 Sekunden auf nicht mehr als das 6-fache seines Volumens expandiert, und man das gashaltige Zahn- pasta-Mousse zur Reinigung der Zahnoberflächen, Zahnzwischenräume uύd der Mundhöhle verwendet.Another object of the invention is a method for dental care and cleaning, characterized in that from a dispenser system, by manually actuating a valve, a toothpaste strand that is not or only slightly foamed is applied to an object suitable for mechanical cleaning of the teeth, the toothpaste strand at 20 ° C and normal pressure has an expansion rate of not more than 100% by volume in 5 seconds and then expands to not more than 6 times its volume in a period of 10-100 seconds, and the gas-containing tooth pasta mousse used to clean the tooth surfaces, interdental spaces and the oral cavity.
1. Poliermittel1. Polish
Als Poliermittel, Putzkörper oder Abrasivmittel werden in der Regel wasserunlösliche anorganische Stoffe eingesetzt, die den Zahnbelag mechanisch entfernen, ohne den Zahnschmelz oder das Dentin zu schädigen. Besonders vorteilhaft kann die Verwendung sehr feinteiliger Poliermittel mit einer mittleren Korngröße von 1 - 200 μm, vorzugsweise 1 - 50 μm und insbesondere 1 - 10 μm sein. Das Poliermittel wird in den erfindungsgemäßen Zusammensetzungen in einer Menge von 5 - 50 Gew.-%, vorzugsweise 8 - 30 Gew.-% und insbesondere 10 - 20 Gew.-% bezogen auf die Gesamtzusammensetzung eingesetzt. Häufig ist es besonders vorteilhaft, eine Kombinationen von Poliermitteln zu verwenden.Water-insoluble inorganic substances are usually used as polishing agents, cleaning agents or abrasives, which mechanically remove the plaque without damaging the enamel or dentin. The use of very finely divided polishing agents with an average grain size of 1 to 200 μm, preferably 1 to 50 μm and in particular 1 to 10 μm can be particularly advantageous. The polishing agent is used in the compositions according to the invention in an amount of 5 to 50% by weight, preferably 8 to 30% by weight and in particular 10 to 20% by weight, based on the total composition. It is often particularly advantageous to use a combination of polishing agents.
Erfϊndungsgemäß geeignet sind neben Kieselsäuren, wasserunlösliche Metaphosphate wie z. B. Natriummetaphosphat, Calciumphosphate wie z. B. Tricalciumphosphat, Calcium- hydrogenphosphat, Calciumhydrogenphosphat-Dihydrat und Calciumpyrophosphat, Cal- ciumcarbonat (Kreide), Magnesiumcarbonat, Magnesiumdihydrogenphosphat, Trimagne- siumphosphat, Aluminiumoxid, calciniertes Aluminiumoxid, Alumimumhydroxid und Aluminiumoxid-Hydrate, Hydroxylapatit sowie verschiedene Silikate. Auch Natriumhy- drogencarbonat ist als Poliermittel erfindungsgemäß einsetzbar, insbesondere in Mischung mit anderen Poliermitteln.In addition to silicas, water-insoluble metaphosphates such as z. B. sodium metaphosphate, calcium phosphates such. B. tricalcium phosphate, calcium hydrogen phosphate, calcium hydrogen phosphate dihydrate and calcium pyrophosphate, calcium carbonate (chalk), magnesium carbonate, magnesium dihydrogen phosphate, trimagnesium phosphate, aluminum oxide, calcined aluminum oxide, aluminum hydroxide and aluminum oxide hydrates, hydroxyapatite and various silicates. Sodium bicarbonate can also be used as a polishing agent according to the invention, in particular in a mixture with other polishing agents.
Vorzugsweise enthält die Zusammensetzung als Poliermittel wenigstens eine Verbindung aus der Gruppe der Kieselsäuren oder Silikate. Unter den Kieselsäure-Poliermitteln sind Fällungs- und Gelkieselsäuren bevorzugt geeignet, da sie bei der Herstellung in ihren Eigenschaften breit variiert werden können und besonders gut mit Fluorid- Wirkstoffen verträglich sind. Sie eignen sich auch besonders gut für die Herstellung von Gel- oder Li- quid-Zahncremes. Gelkieselsäuren werden durch Umsetzung von Natriumsilikatlösungen mit starken wäßrigen Mineralsäuren unter Ausbildung eines Hydrosols, Alterung zum Hydrogel, Waschen und anschließendem Trocknen erzeugt. Erfolgt die Trocknung unter schonenden Bedingungen auf Wassergehalte von 15 - 35 Gew.-%, so werden sogenannte Hydrogelkiesel- säuren erhalten, wie sie beispielsweise aus US 4,153,680 bekannt sind. Durch Trocknung auf Wassergehalte unterhalb 15 Gew.-% erfolgt eine irreversible Schrumpfung der vorher lockeren Struktur des Hydrogels zur dichten Struktur des sogenannten Xerogels. Solche Xerogelkieselsäuren sind z. B. in US 3,538,230 beschrieben.The composition preferably contains at least one compound from the group of silicas or silicates as the polishing agent. Among the silicic acid polishing agents, precipitated and gel silicic acids are preferred because their properties can be varied widely during manufacture and are particularly well tolerated with fluoride active substances. They are also particularly suitable for the production of gel or liquid toothpastes. Gel silicas are produced by reacting sodium silicate solutions with strong aqueous mineral acids to form a hydrosol, aging to the hydrogel, washing and subsequent drying. If drying is carried out under gentle conditions to water contents of 15-35% by weight, so-called hydrogel silicas are obtained, as are known, for example, from US Pat. No. 4,153,680. Drying to water contents below 15% by weight results in an irreversible shrinkage of the previously loose structure of the hydrogel to form the dense structure of the so-called xerogel. Such xerogel silicas are e.g. B. described in US 3,538,230.
Fällungskieselsäuren werden aus wässrigen Alkalisilikat-Lösungen durch Ausfallung mit Mineralsäuren hergestellt und zwar unter Bedingungen, bei denen eine Aggregation zum Sol und Gel nicht eintreten kann. Geeignete Verfahren zur Herstellung von Fällungskieselsäuren sind z. B. in DE-OS 25 22 486 und in DE-OS 31 14 493 beschrieben.Precipitated silicas are produced from aqueous alkali silicate solutions by precipitation with mineral acids and under conditions in which aggregation to form sol and gel cannot occur. Suitable processes for the preparation of precipitated silicas are e.g. B. in DE-OS 25 22 486 and described in DE-OS 31 14 493.
Erfindungsgemäß geeignete Kieselsäurepoliermittel sind beispielsweise unter der Bezeichnung Sident® 8, Zeodent® 113 und 623, Sorbosil® AC39, Tixosü® 123 und 73 im Handel.According to the invention suitable silica abrasives include, for example, under the name ® Sident 8, Zeodent ® 113 and 623, Sorbosil AC39 ®, Tixosü ® 123 and 73 commercially.
Unter den Silikaten sind verschiedene Aluminiumsilikate und Zirkoniumsilikate als Poliermittel bekannt. Auch Natrium-Aluminiumsilikate können als Poliermittel geeignet sein, wie z. B. synthetische Zeolithe, insbesondere Zeolith A.Various aluminum silicates and zirconium silicates are known as polishes among the silicates. Sodium aluminum silicates can also be suitable as polishing agents, such as. B. synthetic zeolites, in particular zeolite A.
Ferner können auch teilchenförmige organische Polymere, z. B. Polymethacrylat oder Polyethylen und Polypropylen einer mittleren Teilchengröße von ca. 5 - 15 μm und einem durchschnittlichen Molekulargewicht von 3000 g/mol als Putzkörper eingesetzt werden.Particulate organic polymers, e.g. B. polymethacrylate or polyethylene and polypropylene an average particle size of about 5 - 15 microns and an average molecular weight of 3000 g / mol can be used as a cleaning body.
2. Feuchthaltemittel2. Humectant
Feuchthaltemittel werden Zahncremes nicht nur zugesetzt, um sie vor Austrockung zu schützen, sie dienen auch der Konsistenzgebung und der Kältestabiltät. Als Feucht- haltemittel können toxikologisch unbedenkliche Polyole eingesetzt werden, wie z. B. Sorbitol, Xylitol, Glycerin, Mannitol, 1,2-Propylenglycol oder Gemische dieser Polyole. Auch Polyethylenglycole mit Molekulargewichten von 400 - 2000 können anteilig als Feuchthaltemittelkomponenten enthalten sein. In einer bevorzugten Ausführungsform enthält das erfindungsgemäße Mittel als Feuchthaltemittel wenigstens Sorbitol, Glycerin oder Xylitol bzw. ein beliebiges Gemisch dieser Substanzen. Das Feuchthaltemittel oder das Gemisch aus Feuchthaltemitteln ist in der Gesamtzusammensetzung in einer Menge von 15 - 85 Gew.-%, vorzugsweise 20 - 70 Gew.-% und insbesondere 30 - 50 Gew.-% enthalten. Vorzugsweise enthält die erfindungsgemäße Zusammensetzung ein Gemisch aus Feuchthaltemitteln, insbesondere mit einem Anteil an Sorbit/Polyethylenglycol im Gewichtsverhälnis 10 : (0,1-1).Moisturizers are not only added to toothpastes to protect them from drying out, they also serve to provide consistency and low-temperature stability. As a moist holding agents can be used toxicologically harmless polyols, such as. B. sorbitol, xylitol, glycerin, mannitol, 1,2-propylene glycol or mixtures of these polyols. Polyethylene glycols with molecular weights of 400-2000 can also be present in part as humectant components. In a preferred embodiment, the agent according to the invention contains at least sorbitol, glycerol or xylitol or any mixture of these substances as a humectant. The total composition contains the humectant or the mixture of humectants in an amount of 15-85% by weight, preferably 20-70% by weight and in particular 30-50% by weight. The composition according to the invention preferably contains a mixture of humectants, in particular with a proportion of sorbitol / polyethylene glycol in a weight ratio of 10: (0.1-1).
3. Oberflächenaktive Substanzen3. Surface-active substances
Eine weitere Verbesserung der Reinigungswirkung der erfindungsgemäßen Zahnreinigungsmittel wird durch Zusatz eines geeigneten oberflächenaktiven Tensids oder Tensid- gemisches erzielt. Eine ausführliche Auflistung geeigneter Tenside ist in U.S. 3,988,433 enthalten, die Teil der Offenbarung der vorliegenden Anmeldung sein sollen. Der Zusatz von Tensiden dient außerdem zur Erzeugung eines Schaums beim Zähnebürsten und damit zur besseren Wirkstoffverteilung, zur Stabilisierung der Poliermittel- und Treibgasdispersion sowie zur Emulgierung oder Solubilisierung der Fette, Öle, Wachse und der Aromaöle. Das Tensid oder Tensidgemisch wird in den erfindungsgemäßen Zusammensetzungen in einer Menge von 0,1 - 10 Gew.-%, vorzugweise 0,3 - 7 und insbesondere 1 - 5 Gew.-% bezogen auf die Gesamtzusammensetzung eingesetzt. Vorzugsweise enthält die Zusammensetzung ein Tensid aus der Gruppe der Aniontenside, der zwitterionischen, der Amphotenside und der Niotenside oder einem beliebigen Gemisch dieser Tenside.A further improvement in the cleaning effect of the tooth cleaning agents according to the invention is achieved by adding a suitable surface-active surfactant or surfactant mixture. A detailed list of suitable surfactants is given in U.S. 3,988,433 which are intended to be part of the disclosure of the present application. The addition of surfactants also serves to generate a foam when brushing teeth and thus to better distribute active ingredients, to stabilize the polishing agent and propellant gas dispersion and to emulsify or solubilize the fats, oils, waxes and aroma oils. The surfactant or surfactant mixture is used in the compositions according to the invention in an amount of 0.1-10% by weight, preferably 0.3-7% and in particular 1-5% by weight, based on the total composition. The composition preferably contains a surfactant from the group of anionic surfactants, zwitterionic surfactants, amphoteric surfactants and nonionic surfactants or any mixture of these surfactants.
Aniontensideanionic surfactants
Geeignete Tenside mit guter Schaumwirkung sind anionische Tenside, die auch eine gewisse enzymhemmende Wirkung auf den bakteriellen Stoffwechsel des Zahnbelags ha- ben. Hierzu gehören Alkali- oder Ammoniumsalze - insbesondere Natriumsalze von C8-Cι8-Alkancarbonsäuren, von Alkylpolyglycolethersulfaten mit 12 - 16 C-Atomen in der linearen Alkylgruppe und 2 - 6 Glycolethergruppen im Molekül, von linearen Alkan- (Cπ-C18)-sulfonaten, Sulfobernsteinsäuremonoalkyl-(C12-C18)-estern, sulfatierten Fettsäu- remonoglyceriden, sulfatierten Fettsäurealkanolamiden, Sulfoessigsäurealkyl-(C12-C16)- estern, Acylsarcosinen, Acyltauriden und Acylisethionaten mit jeweils 8 - 18 C-Atomen in der Acylgruppe. Bevorzugt ist die Verwendung wenigstens eines Aniontensids, insbesondere eines Natriumalkylsulfats mit 12 - 18 C-Atomen in der Alkylgruppe. Ein derartiges Tensid ist Natriumlaurylsulfat, das beispielsweise unter der Bezeichnung Texapon® K1296 im Handel ist.Suitable surfactants with good foaming action are anionic surfactants, which also have a certain enzyme-inhibiting effect on the bacterial metabolism of the plaque. ben. These include alkali or ammonium salts - in particular sodium salts of C 8 -C 8 -alkane carboxylic acids, of alkyl polyglycol ether sulfates with 12-16 C atoms in the linear alkyl group and 2-6 glycol ether groups in the molecule, of linear alkane (C π -C 18 ) sulfonates, sulfosuccinic acid monoalkyl (C 12 -C 18 ) esters, sulfated fatty acid monoglycerides, sulfated fatty acid alkanolamides, sulfoacetic acid alkyl (C 12 -C 16 ) esters, acyl sarcosines, acyl taurides and acyl isethionates each with 8 - 18 C atoms in the acyl group. Preference is given to using at least one anionic surfactant, in particular a sodium alkyl sulfate with 12-18 C atoms in the alkyl group. Such a surfactant is sodium lauryl sulfate which is, for example, under the name Texapon.RTM ® K1296 commercially.
Zwitterionische und ampholytische TensideZwitterionic and ampholytic surfactants
Auch zwitterionische und ampholytische Tenside können, bevorzugt in Kombination mit anionischen Tensiden, eingesetzt werden. Zu den erfindungsgemäß einsetzbaren Ampho- tensiden gehört z. B. Alkylaminopropancarbonsäure. Die bekannteste und am weitesten verbreitete Gruppe der zwitterionischen Tenside ist die der Betain-Tenside, wie z. B. Al- kyldimethylcarboxymethylbetain und Acylaminoalkyldimethylcarboxymethylbetain. Bevorzugt geeignet sind Kokosacylaminopropyldimethylammoniumglycinate, die unter der INCI-Bezeichnung Cocamidopropylbetain bekannt sind. Solche Produkte sind beispielsweise unter der Bezeichnung Tego-Betain® BL 215 und ZF 50 sowie Genagen® CAB im Handel.Zwitterionic and ampholytic surfactants can also be used, preferably in combination with anionic surfactants. The amphoteric surfactants which can be used according to the invention include, for. B. alkylaminopropane carboxylic acid. The best known and most widespread group of zwitterionic surfactants is that of betaine surfactants, such as. B. alkyldimethylcarboxymethylbetaine and acylaminoalkyldimethylcarboxymethylbetaine. Cocosacylaminopropyldimethylammonium glycinates, known under the INCI name Cocamidopropylbetaine, are particularly suitable. Such products are commercially available, for example, under the name Tego-Betain ® BL 215 and ZF 50 and Genagen ® CAB.
Niotensidenonionic surfactants
Besonders geeignet zur Unterstützung der Reinigungswirkung sind nichtionogene Tenside, unter denen die Anlagerungsprodukte von Ethylenoxid an Fettalkohole, an Fettsäuren, an Fettsäuremonoglyceride, an Sorbitan-Fettsäuremonoester oder an Methylglucosid-Fett- säuremonoester bevorzugt sind. Die angelagerte Menge an Ethylenoxid sollte dabei so hoch sein, daß die Tenside wasserlöslich sind, d. h. es sollte wenigstens 1 g des Produktes in 11 Wasser bei 20 °C klar löslich sein. Erfindungsgemäß bevorzugt als nichtionogenes Tensid sind ethoxylierte Glycerylmonoalkylester mit einem Ethoxylierungsgrad von 20 - 60 und einer C8-C18-Alkylkette, wie beispielsweise PEG-30-Glycerylstearat, das z. B. unter der Bezeichnung Tagat® S im Handel ist, und auch als Lösungsvermittler fungiert.Non-ionic surfactants are particularly suitable for supporting the cleaning action, among which the addition products of ethylene oxide with fatty alcohols, with fatty acids, with fatty acid monoglycerides, with sorbitan fatty acid monoesters or with methyl glucoside fatty acid monoesters are preferred. The amount of ethylene oxide added should be so high that the surfactants are water-soluble, ie at least 1 g of the product should be clearly soluble in 11 water at 20 ° C. According to the invention preferably as a nonionic Surfactants are ethoxylated glyceryl monoalkyl esters with a degree of ethoxylation of 20-60 and a C 8 -C 18 alkyl chain, such as, for example, PEG-30 glyceryl stearate, which, for. B. is commercially available under the name Tagat ® S, and also acts as a solubilizer.
Als nichtionogene Tenside eignen sich aber auch Alkyl-(oligo)-glycoside mit 8 - 16 C-Atomen in der Alkylgruppe und einem Oligomerisationsgrad des Glycosidrestes von 1 - 4 Alkyl-(oligo)-glycoside, ihre Herstellung und Verwendung als oberflächenaktive Stoffe sind z. B. aus US-A-3,839,318, DE-A-20 36 472, EP-A-77 167 oder WO-A-93/10132 bekannt. Bezüglich des Glycosidrestes gilt, daß sowohl Monoglycoside (x = 1), bei denen ein Monosaccharidrest glycosidisch an einen Fettalkohol mit 10 bis 16 C-Atomen gebunden ist, als auch oligomere Glycoside mit einem Oligomerisationsgrad x bis 10 geeignet sind. Der Oligomerisationsgrad ist dabei ein statistischer Mittelwert, dem eine für solche technischen Produkte übliche Homologenverteilung zugrunde liegt. Bevorzugt eignet sich als Alkyl-(oligo)-glycosid ein Alkyl-(oligo)-glucosid der Formel RO(C6H,0O)X-H, in der R eine Alkylgruppe mit 12 bis 14 C-Atomen ist und x einen Mittelwert von 1 bis 4 hat. Auch Aminoxide sind als Tenside einsetzbar.Suitable nonionic surfactants are also alkyl (oligo) glycosides with 8-16 carbon atoms in the alkyl group and a degree of oligomerization of the glycoside residue of 1-4 alkyl (oligo) glycosides. Their preparation and use as surface-active substances are e.g. , B. from US-A-3,839,318, DE-A-20 36 472, EP-A-77 167 or WO-A-93/10132 known. With regard to the glycoside residue, both monoglycosides (x = 1), in which a monosaccharide residue is glycosidically bonded to a fatty alcohol having 10 to 16 carbon atoms, and oligomeric glycosides with a degree of oligomerization x to 10 are suitable. The degree of oligomerization is a statistical mean value which is based on a homolog distribution customary for such technical products. Preferably an alkyl group suitable alkyl (oligo) glycoside is an alkyl (oligo) glucoside of the formula RO (C 6 H, 0 O) X -H, in which R 12 to 14 carbon atoms and x is a Has mean of 1 to 4. Amine oxides can also be used as surfactants.
Um eine intensive Reinigungswirkung in Kombination mit guter Schaumbildung und eine ausreichende Solubilisierung der Öle und Wachse sowie der Treibgase zu erreichen, wird in den erfindungsgemäßen Zusammensetzungen vorzugsweise ein Gemisch aus Anion- und Niotensid oder ein Gemisch aus Aniontensid, Niotensid und Betain verwendet, beispielsweise Natriumlaurylsulfat/PEG-30-Glycerylstearat/Cocamidopropylbetain.In order to achieve an intensive cleaning action in combination with good foam formation and sufficient solubilization of the oils and waxes and the propellant gases, a mixture of anionic and nonionic surfactant or a mixture of anionic surfactant, nonionic surfactant and betaine is preferably used in the compositions according to the invention, for example sodium lauryl sulfate / PEG-30 glyceryl stearate / cocamidopropyl.
Lösungsvermittlersolubilizers
Zur besseren Solubilisierung der vorwiegend wasserunlöslichen Öl- und Wachskomponenten und der Treibgase dienen neben Ethanol insbesondere nichtionogene Lösungsvermittler aus der Gruppe der oberflächenaktiven Substanzen. Hierzu zählen, wie bereits erwähnt, insbesondere ethoxylierte Verbindungen mit einem Ethoyxlierungsgrad von 20 - 60. Besonders geeignet für diesen Zweck sind ethoxylierte Fettsäureglyceride, ethoxylierte Fettsäuresorbitanpartialester oder Fettsäurepartialester von Glycerin- oder Sorbitan-Ethoxylaten. Lösungsvermittler aus der Gruppe der ethoxylierten Fettsäuregly- ceride umfassen vor allem Anlagerungsprodukte von 20 bis 60 Mol Ethylenoxid an Mono- und Diglyceride von linearen Fettsäuren mit 12 bis 18 C-Atomen oder an Triglyceride von Hydroxyfettsäuren wie Oxystearinsäure oder Ricinolsäure. Weitere geeignete Lösungsvermittler sind ethoxylierte Fettsäuresorbitanpartialester, z. B. Anlagerungsprodukte von 20 bis 60 Mol Ethylenoxid an Sorbitanmonoester und Sorbitandiester von Fettsäuren mit 12 bis 18 C-Atomen. Ebenfalls geeignete Lösungsvermittler sind Fettsäurepartialester von Glycerin- oder Sorbitan-Ethoxylaten; das sind bevorzugt Mono- und Diester von CI2- C18-Fettsäuren und Anlagerungsprodukten von 20 bis 60 Mol Ethylenoxid an 1 Mol Glycerin oder an 1 Mol Sorbit.In addition to ethanol, non-ionic solubilizers from the group of surface-active substances are used to improve the solubilization of the predominantly water-insoluble oil and wax components and the propellant gases. As already mentioned, these include in particular ethoxylated compounds with a degree of ethoxylation of 20-60. Ethoxylated fatty acid glycerides, ethoxylated fatty acid sorbitan partial esters or fatty acid partial esters of glycerol or sorbitan ethoxylates are particularly suitable for this purpose. Solubilizers from the group of ethoxylated fatty acid gly- cerides primarily include adducts of 20 to 60 moles of ethylene oxide with mono- and diglycerides of linear fatty acids with 12 to 18 carbon atoms or with triglycerides of hydroxy fatty acids such as oxystearic acid or ricinoleic acid. Other suitable solubilizers are ethoxylated fatty acid sorbitan partial esters, e.g. B. Adducts of 20 to 60 moles of ethylene oxide with sorbitan monoesters and sorbitan diesters of fatty acids with 12 to 18 carbon atoms. Also suitable solubilizers are fatty acid partial esters of glycerol or sorbitan ethoxylates; the preferred are mono- and diesters of C I2 - C 18 fatty acids and addition products of 20 to 60 moles of ethylene oxide with 1 mole of glycerol or with 1 mol of sorbitol.
Kationische TensideCationic surfactants
Ferner sind auch einige kationische Tenside wie z. B. Alkyl-trimethylammoniumchlorid, Alkyldimethylbenzylammoniumchlorid, Alkylpyridiniumchlorid, Alkyldimethylhy- droxyethylammoniumchlorid, Acylimidazoliniummethosulfate und Acyloxyethyltri- methylammoniumchlorid als Tenside in den erfindungsgemäßen Mitteln geeignet.Furthermore, some cationic surfactants such as. B. alkyl-trimethylammonium chloride, alkyldimethylbenzylammonium chloride, alkylpyridinium chloride, alkyldimethylhyroxyethylammonium chloride, acylimidazolinium methosulfates and acyloxyethyltrimethylammonium chloride are suitable as surfactants in the agents according to the invention.
4. Öl/Fett- und Wachskomponenten4. Oil / fat and wax components
Die Öl Fett- und Wachskomponenten sind essentielle Bestandteile der erfindungsgemäßen Zusammensetzung. In Kombination mit den Tensiden ermöglichen sie eine partielle Solubilisierung des Treibgases oder Treibgasgemisches, eine Stabilisierung des Schaumes und verleihen der Zahnpastagrundmasse Glanz und Geschmeidigkeit. Erfindungsgemäß können natürliche, chemisch modifizierte und synthetische Wachse, Fette und Öle alleine oder in beliebiger Kombination eingesetzt werden. Die Öl/Fett- und Wachskomponenten sind in einer Menge von 0,1 bis 10 Gew.-%, bezogen auf die Gesamtzusammensetzung, vorzugsweise 0,5 bis 5 Gew.-% und insbesondere 0,8 - 3 Gew.-% enthalten. Öle/FetteThe oil fat and wax components are essential components of the composition according to the invention. In combination with the surfactants, they enable partial solubilization of the propellant gas or propellant gas mixture, stabilization of the foam and give the toothpaste base composition shine and smoothness. According to the invention, natural, chemically modified and synthetic waxes, fats and oils can be used alone or in any combination. The oil / fat and wax components are present in an amount of 0.1 to 10% by weight, based on the total composition, preferably 0.5 to 5% by weight and in particular 0.8 to 3% by weight. Oils / fats
Im Sinne der Erfindung werden hierunter Di- und Triglyceride mit flüssiger bis fester Konsistenz sowie Kohlenwasserstoffe und Silikonöle verstanden, die natürlichen oder synthetischen Ursprungs sein können. Vorzugsweise enthalten' die erfindungsgemäßen Zusammensetzungen als Olkomponenten Triglyceride und/oder ein Paraffinöl. Diese können pflanzlichen, tierischen oder synthetischen Ursprungs sein.For the purposes of the invention, this means di- and triglycerides with a liquid to solid consistency as well as hydrocarbons and silicone oils, which can be of natural or synthetic origin. Preferably, 'the compositions of the invention comprise, as oil components triglycerides and / or a paraffin oil. These can be of vegetable, animal or synthetic origin.
Di- und Triglyceride sind die Di- und Triester von Fettsäuren mit Glycerin, also Acylgly- cerine, wobei das Glycerin mit gleichen oder mit unterschiedlichen Fettsäuren oder Fettsäurederivaten (z. B. Lecithin) verestert sein kann. Bei den Fettsäuren handelt es sich vorzugsweise um C6-C30-Fettsäuren, die gesättigt oder ungesättigt sowie verzweigt oder unverzweigt sein können. Hierzu gehören u. a. die Produkte der Veresterung von Glycerin mit natürlich vorkommenden Fettsäuren wie beispielsweise Capronsäure, Önanthsäure, Caprylsäure, Pelargonsäure, Caprinsäure, Undecansäure, Laurinsäure, Tridecansäure, My- ristinsäure, Pentadecansäure, Palmitinsäure, Margarinsäure, Stearinsäure, Nonadecan- säure, Arachinsäure, Behensäure, Lignocerinsäure, Cerotinsäure, Melissinsäure, 2-Ethyl- hexansäure, Isotridecansäure, Isostearinsäure, Palmitoleinsäure, Ölsäure, Elaidinsäure, Petroselinsäure, Elaeostearinsäure, Erucasäure, Linolsäure, Linolensäure, Arachidonsäure, Clupanodonsäure, Docosahexaensäure und Gadoleinsäure sowie deren technische Mischungen, die z. B. bei der Druckspaltung von natürlichen Fetten und Ölen oder der Di- merisierung von ungesättigten Fettsäuren anfallen. Besonders geeignet kann die Verwendung natürlicher Fette und Öle wie z. B. Rindertalg, Erdnußöl, Rüböl, Baumwoll- saatöl, Sojaöl, Sonnenblumenöl, Palmöl, Palmkernöl, Leinöl, Mandelöl, Rizinusöl, Maisöl, Olivenöl, Rapsöl, Sesamöl, Kakaobutter und Kokosfett und dergleichen sein. Auch die hydrierten oder gehärteten Öle, z. B. hydriertes Sojaöl, Rizinusöl und Erdnußöl können verwendet werden.Di- and triglycerides are the di- and triester of fatty acids with glycerin, ie acylglycerols, whereby the glycerin can be esterified with the same or with different fatty acids or fatty acid derivatives (eg lecithin). The fatty acids are preferably C 6 -C 30 fatty acids, which can be saturated or unsaturated and branched or unbranched. These include the products of the esterification of glycerol with naturally occurring fatty acids such as, for example, caproic acid, oenanthic acid, caprylic acid, pelargonic acid, capric acid, undecanoic acid, lauric acid, tridecanoic acid, myristic acid, pentadecanoic acid, palmitic acid, margaric acid, stearic acid, nonadecanoic acid, arenic acid, arachinic acid , Lignoceric acid, cerotinic acid, melissic acid, 2-ethylhexanoic acid, isotridecanoic acid, isostearic acid, palmitoleic acid, oleic acid, elaidic acid, petroselinic acid, elaeostearic acid, erucic acid, linoleic acid, linolenic acid, arachidonic acid, clupanodonic acid and technical blends, docosaoleic acid and docosaoleic acid. B. in the pressure splitting of natural fats and oils or the dimerization of unsaturated fatty acids. The use of natural fats and oils such as e.g. B. beef tallow, peanut oil, rape oil, cottonseed oil, soybean oil, sunflower oil, palm oil, palm kernel oil, linseed oil, almond oil, castor oil, corn oil, olive oil, rapeseed oil, sesame oil, cocoa butter and coconut oil and the like. The hydrogenated or hardened oils, e.g. B. hydrogenated soybean oil, castor oil and peanut oil can be used.
Erfindungsgemäß einsetzbar sind auch dünn- bis dickflüssige Silikonöle oder natürliche und synthetische Kohlenwasserstoffe wie beispielsweise dünn- bis dickflüssige Paraffin- öle, Isohexadecan, Isoeicosan oder Polydecene, die z. B. unter der Bezeichnung Emery® 3004, 3006, 3010, Ethylflo® oder Nexbase® 2004G erhältlich sind. Auch der Einsatz sogenannter inverser Fette (z. B. Ester vicinaler Tricarbonsäuren mit C6-C30-Fettalkoholen) oder von Glyceryltrialkyethern ist hier denkbar.Thin to viscous silicone oils or natural and synthetic hydrocarbons such as thin to viscous paraffin can also be used according to the invention. oils, isohexadecane, isoeicosane or polydecenes, e.g. B. are available under the name Emery ® 3004, 3006, 3010, Ethylflo ® or Nexbase ® 2004G. The use of so-called inverse fats (e.g. esters of vicinal tricarboxylic acids with C 6 -C 30 fatty alcohols) or glyceryl trialkyethers is also conceivable here.
Wachsewaxes
Unter Wachsen werden natürlich oder künstlich gewonnene Stoffe mit folgenden Eigenschaften verstanden: sie sind von fester bis brüchig harter Konsistenz, grob bis feinkristallin, durchscheinend bis opak, jedoch nicht glasartig, und schmelzen oberhalb von 35 °C ohne Zersetzung. Sie sind schon wenig oberhalb des Schmelzpunktes niedrigviskos und nicht fadenziehend und zeigen eine stark temperaturabhängige Konsistenz und Löslichkeit. Die häufigsten Vertreter aus der Gruppe der Wachse sind chemisch gesehen Ester aus Fettsäuren und höheren Fettalkoholen, die tierischen und pflanzlichen Ursprungs sind. Erfindungsgemäß verwendbar sind natürliche pflanzliche Wachse, wie z. B. Jojobaöl, Candelillawachs, Carnaubawachs, Japanwachs, Espartograswachs, Korkwachs, Guaru- mawachs, Reiskeimölwachs, Zuckerrohrwachs, Ouricurywachs, Montanwachs, Sonnenblumenwachs, Fruchtwachse wie Orangenwachse, Zitronenwachse, Grapefruitwachs, Lorbeerwachs (=Bayberrywax) und tierische Wachse, wie z. B. Bienenwachs, Schellackwachs, Walrat, Wollwachs und Bürzelfett. Es kann auch vorteilhaft sein, hydrierte oder gehärtete Wachse einzusetzen. Zu den erfindungsgemäß verwendbaren natürlichen Wachsen zählen auch die Mineralwachse, wie z. B. Ceresin und Ozokerit oder die petrochemi- schen Wachse, wie Paraffinwachse (z. B. Vaseline) und Mikrowachse. Als Wachskomponente sind auch chemisch modifizierte Wachse, wie z. B. Montanesterwachse, Sasolwach- se und hydrierte Jojobawachse einsetzbar. Zu den synthetischen Wachsen, die erfindungsgemäß einsetzbar sind, zählen bespielsweise auch wachsartige Polyalkylenwachse und Silikonwachse.Waxes are understood to mean naturally or artificially obtained substances with the following properties: they have a firm to fragile hard consistency, coarse to fine crystalline, translucent to opaque, but not glassy, and melt without decomposition above 35 ° C. They are low viscosity and not stringy a little above the melting point and show a strongly temperature-dependent consistency and solubility. From a chemical point of view, the most common representatives from the wax group are esters from fatty acids and higher fatty alcohols, which are of animal and vegetable origin. Natural vegetable waxes, such as, for example, B. jojoba oil, candelilla wax, carnauba wax, Japanese wax, esparto grass wax, cork wax, guaruma wax, rice germ oil wax, sugar cane wax, ouricury wax, montan wax, sunflower wax, fruit waxes such as orange waxes, lemon waxes, grapefruit wax, laurel wax (= Bayberry wax, as well as animal wax). B. beeswax, shellac wax, walrus, wool wax and pretzel fat. It can also be advantageous to use hydrogenated or hardened waxes. The mineral waxes that can be used according to the invention also include the mineral waxes, such as. B. ceresin and ozokerite or the petrochemical waxes, such as paraffin waxes (z. B. Vaseline) and micro waxes. As a wax component, chemically modified waxes, such as. B. Montanester waxes, Sasol waxes and hydrogenated jojoba waxes can be used. The synthetic waxes which can be used according to the invention also include, for example, wax-like polyalkylene waxes and silicone waxes.
Erfindungsgemäß einsetzbar sind auch synthetische Wachse, insbesondere die Ester aus C6-C30-Fettsäuren mit C6-C30-Fettalkoholen, die natürlichen oder synthetischen Ursprungs sein können. Sowohl die Fettsäure-Komponente als auch die Fettalkohol-Komponente kann geradkettig oder verzweigt und gesättigt oder einfach oder mehrfach ungesättigt sein.Synthetic waxes can also be used according to the invention, in particular the esters of C 6 -C 30 fatty acids with C 6 -C 30 fatty alcohols, which can be of natural or synthetic origin. Both the fatty acid component and the fatty alcohol component can be straight-chain or branched and saturated or mono- or polyunsaturated.
Vorzugsweise wird die Wachskomponente gewählt aus der Gruppe der pflanzlichen oder der tierischen und/oder der Paraffinwachse bzw. einem beliebigen Gemisch dieser Wachse.The wax component is preferably selected from the group of vegetable or animal and / or paraffin waxes or any mixture of these waxes.
5. Treibgas und Spender5. Propellant and donor
Vorzugweise ist das Treibgas oder Treibgasgemisch in den erfindungsgemäßen Zusammensetzungen in einer Menge von wenigstens 1 Gew.-% enthalten. Besonders bevorzugt ist ein Gehalt von 1 - 10 Gew.-% und insbesondere 3 - 4 Gew.-%. Vorzugsweise enthält das Treibgas oder Treibgasgemisch wenigstens eine Komponente, die bei Normaldruck einen Siedepunkt im Bereich von 0 - 40 °C, vorzugsweise 15 - 35 °C und insbesondere 20 - 30 °C hat. Auf diese Weise läßt sich in Kombination mit nachstehend beschriebenen Spendersystemen ein „post-foaming" Effekt erzeugen, wobei kohlenwasserstoffhaltige Treibgase besonders vorteilhaft sind. Das Treibgas enthält vorzugsweise ein C5-Alkan. Unter diesen - n-Pentan, 2-Methylbutan (= Isopentan) und Neopentan - ist das 2 -Methylbutan mit einem Siedpunkt von 29 °C bevorzugt geeignet. Vorzugsweise wird als Treibgas ein Gemisch eines C4-Alkans und eines C5-Alkans eingesetzt, wobei 1 :3 - 3:1 -Gemische (Gewichtsverhältnis) aus Isopentan/Isobutan erfindungsgemäß besonders gut geeignet sind, um die zeitverzögerte Aufschäumung des Zahnreinigungsmittels zu gewährleisten. Derartige Formulierungen sind direkt nach der Abgabe aus dem Spender noch gelartig und quellen dann auf der Zahnbürste allmählich zu einem Schaum auf, der sich besonders bei Körpertemperatur, also bei Applikation der Zusammensetzung im Mundinnenraum, relativ schnell entfaltet.The propellant gas or propellant gas mixture is preferably present in the compositions according to the invention in an amount of at least 1% by weight. A content of 1-10% by weight and in particular 3-4% by weight is particularly preferred. The propellant gas or propellant mixture preferably contains at least one component which has a boiling point in the range from 0 to 40 ° C., preferably 15 to 35 ° C. and in particular 20 to 30 ° C. at normal pressure. In this way, a "post-foaming" effect can be produced in combination with the dispenser systems described below, hydrocarbon-containing propellants being particularly advantageous. The propellant preferably contains a C 5 alkane. Among these - n-pentane, 2-methylbutane (= isopentane ) and neopentane - 2-methylbutane with a boiling point of 29 ° C. is preferably suitable, preferably a mixture of a C 4 alkane and a C 5 alkane is used as the propellant, 1: 3 - 3: 1 mixtures (weight ratio ) made of isopentane / isobutane are particularly suitable according to the invention in order to ensure the time-delayed foaming of the tooth cleaning agent. Such formulations are still gel-like immediately after being dispensed from the dispenser and then swell gradually on the toothbrush to form a foam which is particularly at body temperature, that is, when the composition is applied inside the mouth, unfolds relatively quickly.
Die Zahnreinigungsmittel werden in handelsüblichen Abfüllanlagen zusammen mit dem durch Druck verflüssigten Treibgas oder Treibgasgemisch in Spendersysteme abgefüllt, die ausreichend druckresistent sind, daß das Treibgas in der Zusammensetzung verflüssigt vorliegt. Als Spender für die Zusammensetzung eignet sich beispielsweise ein Behälter mit Ventil aus einem starren Material, der mit einer Vorrichtung ausgestattet ist, die zum Ausstoßen der in ihr bevorrateten Zusammensetzung (also Zahnreinigungsmittel und Treibgas) die Kontraktionskraft eines gedehnten Gummischlauches und/oder eines gedehnten Produktbehälters einsetzt. Ein solcher Spender ist beispielsweise in EP 69699 beschrieben. Auch die von der 3D Dispenser-Distributions GmbH unter der Bezeichnung FlexPack® angebotenen Behälter benutzen die Rückstellkraft eines gedehnten Gummis zum Ausstoßen der Zusammensetzung. Erfindungsgemäß bevorzugt geeignet sind Behälter, die einen gefalteten, im wesentlichen gasundurchlässigen flexiblen Innenbeutel aus einem chemisch inerten Kunststoff (z. B. PET) enthalten, der von einem elastischen, dickwandigen Gummischlauch umgeben ist. Derartige Spender sind beispielsweise in US 5,927,551, US 4,964,540 und EP 69738 beschrieben und werden von der Firma Exxel Container unter der Bezeichnung Atmos™ Dispensing System vertrieben. In Kombination mit derartigen Spendern kann auch reines Butan als Treibgas bereits einen "post-foaming" Effekt erzeugen.The tooth cleaning agents are filled in commercial filling systems together with the liquefied propellant gas or propellant gas mixture into dispenser systems which are sufficiently pressure-resistant that the propellant gas is liquefied in the composition. A container, for example, is suitable as a dispenser for the composition with valve made of a rigid material, which is equipped with a device which uses the contraction force of a stretched rubber hose and / or a stretched product container to eject the composition stored therein (i.e. dentifrice and propellant). Such a dispenser is described for example in EP 69699. The containers offered by 3D Dispenser-Distributions GmbH under the name FlexPack ® also use the restoring force of a stretched rubber to eject the composition. According to the invention, preference is given to containers which contain a folded, essentially gas-impermeable flexible inner bag made of a chemically inert plastic (for example PET) which is surrounded by an elastic, thick-walled rubber tube. Such dispensers are described for example in US 5,927,551, US 4,964,540 and EP 69738 and are sold by the Exxel Container company under the name Atmos ™ Dispensing System. In combination with such dispensers, pure butane as the propellant gas can already produce a "post-foaming" effect.
Ebenso sind Zweikammer- Aerosoldosen mit Innenbeutel bevorzugt als Spender geeignet. Diese enthalten im Innenbeutel das Füllgut (Zahnreinigungsmittel mit verflüssigtem Gas) und in der äußeren Kammer ein weiteres Treibgas, das zum Ausstoßen der Zusammensetzung bei Betätigung des Ventils dient. Derartige Systeme können entweder durch eine Öffnung am Dosenboden oder - wie beim sogenannten „under cup System" - durch Anheben des Ventils befüllt werden.Likewise, two-chamber aerosol cans with inner bags are preferably suitable as dispensers. These contain the contents (tooth cleaning agent with liquefied gas) in the inner bag and a further propellant gas in the outer chamber, which serves to expel the composition when the valve is actuated. Such systems can either be filled through an opening in the bottom of the can or - as in the so-called "under cup system" - by lifting the valve.
Bindemittel/VerdickungsmittelBinders / thickening agents
Das erfindungsgemäße Mittel enthält in einer bevorzugten Ausführungsform zusätzlich wenigstens ein Binde- oder Verdickungsmittel. Binde- oder Verdickungsmittel wirken u. a. konsistenzregulierend und tragen dazu bei, eine Separation der flüssigen und festen Bestandteile zu verhindern. Sie sind in den erfindungsgemäßen Zusammensetzungen in einer Gesamtmenge von 0,1 - 5 Gew.-%, vorzugsweise 0,1 - 3 Gew.-% und insbesondere 0,5 - 2 Gew.-% enthalten. Verwendet werden beispielsweise natürliche und/oder synthetische wasserlösliche Polymere wie Alginate, Carragene, Agar-Agar, Guar-Gum, Gummi arabicum, Succinoglycan-Gum, Guarmehl, Johannisbrotkernmehl, Tragant, Karaya- Gummi, Xanthan, Pektine, Cellulose und deren ionogene und nicht-ionogene Derivate wie z. B. Carboxymethylcellulose, Hydroxyethylcellulose oder Methylhydroxypropyl- cellulose, hydrophob modifizierte Cellulosen, Stärke- und Stärkeether. Auch wasserlösliche Carboxyvinylpolymere (z. B. Carbopol®-Typen), Polyvinylalkohol, Polyvinylpyrroli- don und höhermolekulare Polyethylenglycole (insbesondere solche mit Molekulargewichten von 102 - 105 D) eignen sich als Binde- und Verdickungsmittel. Ebenso können Schichtsilikate und feinteilige Kieselsäuren (Aerogelkieselsäuren und pyrogene Kieselsäuren) diese Funktion erfüllen. Bevorzugt geeignet ist pulverförmige Cellulose, die beispielsweise von J. Rettenmaier & Söhne unter der Bezeichnung Arbocel® oder Vitacel® angeboten wird. Arbocel® CGP 5000, eine hochviskose Paste aus Pulvercellulose mit thixotropen Eigenschaften, ist erfindungsgemäß besonders bevorzugt geeignet. Arbocel®- Cellulosen sind äußerst effektive Verdicker, die auch bei niedriger Einsatzkonzentration die Viskosität der Zusammensetzungen beträchtlich erhöhen, gegen ionische Bestandteile inert sind, und sich gut mit weiteren Verdickungsmitteln kombinieren lassen.In a preferred embodiment, the agent according to the invention additionally contains at least one binding or thickening agent. Binding agents or thickeners have a consistency-regulating effect and help to prevent separation of the liquid and solid components. They are contained in the compositions according to the invention in a total amount of 0.1-5% by weight, preferably 0.1-3% by weight and in particular 0.5-2% by weight. For example, natural and / or synthetic water-soluble polymers such as alginates, carragenes, agar-agar, guar-gum, rubber are used arabicum, succinoglycan gum, guar flour, locust bean gum, tragacanth, karaya gum, xanthan, pectins, cellulose and their ionogenic and non-ionogenic derivatives such as B. carboxymethyl cellulose, hydroxyethyl cellulose or methyl hydroxypropyl cellulose, hydrophobically modified celluloses, starch and starch ethers. And water-soluble carboxyvinyl polymers (for example Carbopol ® grades.), Polyvinyl alcohol, polyvinylpyrrolidone and high molecular weight polyethylene glycols (particularly those having molecular weights of 10 2 - 10 5 D) are useful as binders and thickeners. Layered silicates and finely divided silicas (airgel silicas and pyrogenic silicas) can also fulfill this function. Particularly suitable is powdered cellulose, which is offered for example, from J. Rettenmaier & Söhne under the name of Arbocel ® or Vitacel ®. Arbocel ® CGP 5000, a highly viscous paste made of powder cellulose with thixotropic properties, is particularly preferably suitable according to the invention. Arbocel ® celluloses are extremely effective thickeners, which increase the viscosity of the compositions considerably even at low use concentrations, are inert to ionic components and can be easily combined with other thickeners.
Zusätzliche WirkstoffeAdditional active ingredients
Eine weitere bevorzugte Ausführungsform des Zahnreinigungsmittels ist dadurch gekennzeichnet, daß es als zusätzliche Wirkstoffe Antikarieswirkstoffe, antimikrobielle Wirkstoffe, Zahnstein-Inhibitoren, Remineralisierungswirkstoffe, Geschmacksstoffe oder eine beliebige Kombination dieser Stoffe enthält.A further preferred embodiment of the tooth cleaning agent is characterized in that it contains anti-caries agents, antimicrobial agents, tartar inhibitors, remineralizing agents, flavoring agents or any combination of these substances as additional agents.
Antikaries- WirkstoffeAnti-caries agents
Zur Bekämpfung von und Vorbeugung gegen Karies eignen sich vor allem Fluorverbindungen, bevorzugt aus der Gruppe der Fluoride oder Monofluorophosphate in einer Menge von 0,1 - 0,5 Gew.-% Fluor. Geeignete Fluorverbindungen sind z. B. Natriumfluorid, Kaliumfluorid, Zinnfluorid, Dinatriummonofluorophosphat (Na2PO3F), Dikalium- monofluorophosphat oder das Fluorid einer organischen Aminoverbindung. Antimikrobielle WirkstoffeTo combat and prevent caries, fluorine compounds are particularly suitable, preferably from the group of fluorides or monofluorophosphates in an amount of 0.1-0.5% by weight of fluorine. Suitable fluorine compounds are e.g. As sodium fluoride, potassium fluoride, tin fluoride, disodium monofluorophosphate (Na 2 PO 3 F), dipotassium monofluorophosphate or the fluoride of an organic amino compound. Antimicrobial agents
Als antimikrobielle Komponente eignen sich z. B. Phenole, Resorcine, Bisphenole, Sa- licylanilide und -amide und deren halogenierte Derivate, halogenierte Carbanilide und p-Hydroxybenzoesäureester. Unter den antimikrobiellen Komponenten sind diejenigen besonders geeignet, die das Wachstum von Plaque-Bakterien hemmen. Beispielsweise sind halogenierte Diphenylether, wie 2,4-Dichlor-2'-hydroxydiphenylether, 4,4'-Dichlor- 2 ' -hydroxy diphenylether, 2,4,4 ' -Tribrom-2 ' -hydroxy diphenylether, 2,4,4 ' -Trichlor-2 ' - hydroxydiphenylether (Triclosan) als antimikrobielle Wirkstoffe geeignet. Neben Brom- chlorophen, Bisbiguaniden wie Chlorhexidin und Alexidin, Phenylsalicylsäureestern und 5-Amino-l,3-bis(2-ethylhexyl)-hexahydro-5-methylpyrimidin (Hexetidin) wirken auch Zink- und Kupferionen antimikrobiell, wobei synergistische Effekte insbesondere in Kombination mit Hexetidin und Triclosan auftreten. Auch quartäre Ammoniumverbindungen, wie z. B. Cetylpyridiniumchlorid, Benzalkoniumchlorid, Domiphenbromid und Dequaliniumchlorid sind einsetzbar. Als antimikrobiell wirksam haben sich auch Octapi- nol, Octenidine und Sanguinarin erwiesen. Die antimikrobiellen Wirkstoffe werden bevorzugt in Mengen von 0,01 - 1 Gew.-% in den erfindungsgemäßen Mitteln verwendet und können auch in Form von Nanopartikeln eingesetzt werden. Besonders bevorzugt wird Irgacare® MP in einer Menge von 0,01 - 0,3 Gew.-% verwendet.As an antimicrobial component are, for. B. phenols, resorcinols, bisphenols, salicylanilides and amides and their halogenated derivatives, halogenated carbanilides and p-hydroxybenzoic acid esters. Among the antimicrobial components, those which inhibit the growth of plaque bacteria are particularly suitable. For example, halogenated diphenyl ethers, such as 2,4-dichloro-2'-hydroxydiphenyl ether, 4,4'-dichloro-2'-hydroxy diphenyl ether, 2,4,4 '-tribromo-2'-hydroxy diphenyl ether, 2,4,4 '-Trichlor-2' - hydroxydiphenyl ether (triclosan) suitable as antimicrobial agents. In addition to bromochlorophene, bisbiguanides such as chlorhexidine and alexidine, phenylsalicylic acid esters and 5-amino-1,3-bis (2-ethylhexyl) hexahydro-5-methylpyrimidine (hexetidine), zinc and copper ions also have an antimicrobial effect, with synergistic effects in particular in combination occur with hexetidine and triclosan. Quaternary ammonium compounds, such as. B. cetylpyridinium chloride, benzalkonium chloride, domiphen bromide and dequalinium chloride can be used. Octapinol, octenidines and sanguinarine have also proven to be antimicrobial. The antimicrobial active ingredients are preferably used in amounts of 0.01-1% by weight in the agents according to the invention and can also be used in the form of nanoparticles. Irgacare ® MP is particularly preferred in an amount from 0.01 to 0.3 wt .-% is used.
ZahnsteininhibitorenTartar inhibitors
Bei Zahnstein handelt es sich um Mineralablagerungen, die dem natürlichen Zahnschmelz sehr ähnlich sind. Um eine Zahnsteinbildung zu inhibieren, werden den erfindungsgemäßen Zahnreinigungsmitteln Stoffe zugesetzt, die gezielt in die Kristallkeimbildung eingreifen und bereits vorhandene Keime am Weiterwachsen hindern. Hierbei handelt es sich beispielsweise um kondensierte Phosphate, die bevorzugt gewählt werden aus der Gruppe der Tripolyphosphate, der Pyrophophate, der Trimetaphosphate oder deren Gemischen. Sie werden in Form ihrer Alkali- oder Ammoniumsalze, bevorzugt in Form ihrer Natrium- oder Kaliumsalze eingesetzt. Wäßrige Lösungen dieser Phosphate reagieren typischerweise alkalisch, so daß der pH- Wert der erfindungsgemäßen Zahnpflegemittel ggf. durch Zusatz von Säure auf Werte von 7,5 - 9 eingestellt wird. Als Säuren können dabei z. B. Zitronensäure, Phosphorsäure oder saure Salze, z. B. NaH2PO4 verwendet werden. Der gewünschte pH- Wert des Zahnpflegemittels kann aber auch durch Zusatz saurer Salze der kondensierten Phosphate, also z. B. K2H2P2O7, eingestellt werden.Tartar is mineral deposits that are very similar to natural tooth enamel. In order to inhibit tartar formation, substances are added to the tooth cleaning agents according to the invention which specifically intervene in the crystal nucleation and prevent existing germs from continuing to grow. These are, for example, condensed phosphates, which are preferably selected from the group of tripolyphosphates, pyrophophates, trimetaphosphates or mixtures thereof. They are used in the form of their alkali or ammonium salts, preferably in the form of their sodium or potassium salts. Aqueous solutions of these phosphates typically have an alkaline reaction, so that the pH of the dentifrices according to the invention is adjusted to values of 7.5-9, if necessary by adding acid. As acids z. B. citric acid, phosphoric acid or acid salts, e.g. B. NaH 2 PO 4 can be used. The desired pH of the dentifrice can also be achieved by adding acidic salts of the condensed phosphates, e.g. B. K 2 H 2 P 2 O 7 can be set.
Auch Gemische verschiedener kondensierter Phosphate und/oder hydratisierte Salze der kondensierten Phosphate sind erfϊndungsgemäß einsetzbar. Zahnsteininhibitoren werden üblicherweise in Mengen von 0,1 - 5 Gew.-%, bevorzugt 0,1 - 3 Gew.-% und insbesondere 0,1 - 2 Gew.-% in den erfindungsgemäßen Mitteln eingesetzt.Mixtures of different condensed phosphates and / or hydrated salts of the condensed phosphates can also be used according to the invention. Tartar inhibitors are usually used in amounts of 0.1-5% by weight, preferably 0.1-3% by weight and in particular 0.1-2% by weight in the agents according to the invention.
Weitere geeignete Zahnsteininhibitoren sind Organophosphonate wie 1-Azacycloheptan- 2,2-diphosphonat (Na-Salz) oder l-Hydroxyethan-l,l-diphosphonat (Na-Salz) und Zink- citrat.Other suitable tartar inhibitors are organophosphonates such as 1-azacycloheptane-2,2-diphosphonate (Na salt) or 1-hydroxyethane-1, 1-diphosphonate (Na salt) and zinc citrate.
RemineralsierungswirkstoffeRemineralsierungswirkstoffe
Die erfindungsgemäßen Mittel enthalten vorzugsweise auch Stoffe, die eine Reminerali- sierung des Zahnschmelzes fördern und Dentalläsionen zu schließen vermögen. Diese sind üblicherweise in einer Gesamtmenge von 0,1 - 10 Gew.-%, vorzugsweise 0,1 — 5 Gew.-% und insbesondere 0,1 - 3 Gew.-% enthalten. Hierzu gehören z. B. Fluoride, Phosphatsalze des Calciums wie z. B. Calciumglycerinphosphate, Calciumhydrogen- phopsphat, Hydroxylapatit, Fluorapatit, F-dotierter Hydroxylapatit, Dicalciumphosphat- dihydrat sowie Calciumfluorid. Aber auch Magnesiumsalze wie z. B. Magnesiumsulfat, Magnesiumfluorid oder Magnesiummonofluorophosphat wirken remineralisierend.The agents according to the invention preferably also contain substances which promote remineralization of the tooth enamel and are able to close dental lesions. These are usually contained in a total amount of 0.1-10% by weight, preferably 0.1-5% by weight and in particular 0.1-3% by weight. These include e.g. B. fluorides, phosphate salts of calcium such. As calcium glycerol phosphates, calcium hydrogen phosphate, hydroxyapatite, fluoroapatite, F-doped hydroxyapatite, dicalcium phosphate dihydrate and calcium fluoride. But also magnesium salts such as. B. magnesium sulfate, magnesium fluoride or magnesium monofluorophosphate have a remineralizing effect.
Geschmacksstoffeflavorings
Vorzugsweise enthalten die erfindungsgemäßen Mittel Geschmacksstoffe, zu denen z. B. Süßungsmittel und/oder Aromaöle gehören. Als Süßungsmittel eignen sich beispielsweise Saccharinate (insbesondere Natriumsaccharinat), Cyclamate (insbesondere Natrium- cyclamat) sowie Sucrose, Lactose, Maltose oder Fructose. Als Aromaöle kommen alle für Mund- und Zahnpflegemittel gebräuchlichen natürlichen und synthetischen Aromen in Frage. Natürliche Aromen können sowohl in Form der aus den Drogen isolierten etheri- schen Öle (Mischung) als auch in Form der hieraus isolierten Einzelkomponenten verwendet werden. Bevorzugt sollte wenigstens ein Aromaöl aus der Gruppe Pfefferminzöl, Krausenminzöl, Anisöl, Sternanisöl, Kümmelöl, Eukalyptusöl, Fenchelöl, Zimtöl, Nelkenöl, Geraniumöl, Salbeiöl, Pimentöl, Thymianöl, Majoranöl, Basilikumöl, Citrusöl, Gaultheriaöl oder eine/mehrere daraus isolierte bzw. synthetisch erzeugte Komponenten dieser Öle enthalten sein. Die wichtigsten Komponenten der genannten Öle sind z. B. Menthol, Carvon, Anethol, Cineol, Eugenol, Zimtaldehyd, Caryophyllen, Geraniol, Citro- nellol, Linalool, Salven, Thymol, Terpinen, Terpinol, Methylchavicol und Methyl- salicylat. Weitere geeignete Aromen sind z. B. Menthylacetat, Vanillin, Jonone, Linalyl- acetat, Rhodinol und Piperiton.The agents according to the invention preferably contain flavorings, to which e.g. B. sweeteners and / or aromatic oils. Examples of suitable sweeteners are saccharinates (in particular sodium saccharinate), cyclamates (in particular sodium cyclamate) and sucrose, lactose, maltose or fructose. Aromatic oils that can be used are all natural and synthetic aromas that are common for oral and dental care products. Natural aromas can be used both in the form of the essential oils (mixture) isolated from the drugs and in the form of the individual components isolated from them. Preferably at least one aromatic oil from the group peppermint oil, Spearmint oil, anise oil, star anise oil, caraway oil, eucalyptus oil, fennel oil, cinnamon oil, clove oil, geranium oil, sage oil, allspice oil, thyme oil, marjoram oil, basil oil, citrus oil, Gaultheria oil or one / more components of these oils isolated or synthetically produced. The most important components of the oils mentioned are e.g. B. menthol, carvone, anethole, cineol, eugenol, cinnamaldehyde, caryophyllene, geraniol, citronellol, linalool, salvos, thymol, terpinene, terpinol, methylchavicol and methyl salicylate. Other suitable flavors are e.g. B. menthyl acetate, vanillin, jonone, linalyl acetate, rhodinol and piperiton.
Eine besonders bevorzugte Ausführungsform des Zahnreinigungsmittel enthält a) 5 - 30 Gew.-% eines Poliermittels; b) 20 - 85 Gew.-% eines Feuchthaltemittels; c) 0,3 - 5 Gew.-% eines Tensids oder Tensidgemisches; d) 0,1 - 40 Gew.-% eines Öls, Fetts und/oder Wachses, e) 0,05 - 0,5 Gew.-% eines Fluorids; f) 5 - 50 Gew.-% Wasser g) 1 - 10 Gew.-% eines C4- und/oder C5-haltigen Treibgases oder Treibgasgemisches und in einem Spendersystem mit manuell betätigbarem Ventil. Diese Kombination ermöglicht einen besonders guten post-foaming Effekt und eine sehr leichte Verteilbarkeit.A particularly preferred embodiment of the tooth cleaning agent contains a) 5-30% by weight of a polishing agent; b) 20-85% by weight of a humectant; c) 0.3-5% by weight of a surfactant or surfactant mixture; d) 0.1-40% by weight of an oil, fat and / or wax, e) 0.05-0.5% by weight of a fluoride; f) 5-50% by weight of water g) 1-10% by weight of a C 4 and / or C 5 -containing propellant gas or propellant gas mixture and in a dispenser system with a manually operable valve. This combination enables a particularly good post-foaming effect and very easy distribution.
Weitere übliche InhaltsstoffeOther common ingredients
Das erfindungsgemäße Mittel kann vorzugsweise eine Reihe weiterer Zahnpastainhaltsstoffe enthalten. Hierzu gehören u. a.:The agent according to the invention can preferably contain a number of further toothpaste ingredients. These include a .:
• Vitamine, z. B. Retinol, Biotin, Tocopherol, Ascorbinsäure und deren Derivate (z. B. Ester, Salze);Vitamins, e.g. B. retinol, biotin, tocopherol, ascorbic acid and their derivatives (e.g. esters, salts);
• Pigmente, z. B. Titandioxid oder Zinkoxid;• pigments, e.g. B. titanium dioxide or zinc oxide;
• Bleichmittel;• bleach;
• Farbstoffe;• dyes;
• pH-Stellmittel und Puffersubstanzen, z. B. Natriumeitrat, Natriumbicarbonat oder Kalium- und Natriumphosphate,• pH adjusting agents and buffer substances, e.g. B. sodium citrate, sodium bicarbonate or potassium and sodium phosphates,
• Natriumbenzoat; • wundheilende und entzündungshemmende Stoffe wie z. B. AUantoin, Harnstoff, Pan- thenol, Azulen oder Kamillenextrakt, Acetylsalicylsäure-Derivate, Rhodanid; Wasserstoffperoxid• sodium benzoate; • wound healing and anti-inflammatory substances such as B. AUantoin, urea, panthenol, azulene or chamomile extract, acetylsalicylic acid derivatives, rhodanide; hydrogen peroxide
• Zink- und Mangansulfat • Zinc and manganese sulfate
Erfindungsgemäße BeispieleExamples according to the invention
Die Herstellung des Zahnpflegereinigungsmittels erfolgte unter Entgasung, d. h. im mäßigen Vakuum (< 50 mbar), bei Raumtemperatur.The dentifrice was prepared with degassing, i.e. H. in a moderate vacuum (<50 mbar), at room temperature.
Allgemeine VorschriftGeneral rule
Die Feuchthaltemittel, Kieselsäuren und ggf. weitere Poliermittel wurden zusammen mit entsalztem Wasser im Vakuum unter Rühren homogenisiert. Anschließend wurden die löslichen Salze und Farbstoffe zugegeben. Cellulose wurde - falls verwendet - in etwas Wasser suspendiert und in die Masse eingearbeitet. Organische Bindemittel (z. B. Xanthan gum etc.) wurden in PEG dispergiert und anschließend unter Rühren in die Masse eingearbeitet. Nach Quellung der Masse wurden die Olkomponenten und Tenside, die vorher miteinander bei 60 - 85 °C emulgiert worden waren, zugegeben, dann die Aromastoffe, und solange weitergerührt, bis eine homogene Masse mit glatter Struktur erhalten wurde.The humectants, silicas and possibly other polishing agents were homogenized together with demineralized water in a vacuum with stirring. The soluble salts and dyes were then added. Cellulose - if used - was suspended in a little water and worked into the mass. Organic binders (e.g. xanthan gum etc.) were dispersed in PEG and then incorporated into the mass with stirring. After swelling of the mass, the oil components and surfactants, which had previously been emulsified at 60-85 ° C., were added, then the flavorings, and stirring was continued until a homogeneous mass with a smooth structure was obtained.
Die Pastenmasse (90 - 99 Gew.-%) wurde zusammen mit 1 - 10 Gew.-% des Treibgases/Treibgasgemisches in das Atmos™ Dispensing System (70 oder 140 mL) der Exxel Container Inc. oder in eine Zweikammer-Aerosol-Dose unter den für solche Systeme üblichen Bedingungen abgefüllt (Abfülldruck: ca. 40 bar).The paste mass (90-99% by weight) was placed together with 1-10% by weight of the propellant gas / propellant gas mixture in the Atmos ™ dispensing system (70 or 140 ml) from Exxel Container Inc. or in a two-chamber aerosol can bottled under the usual conditions for such systems (filling pressure: approx. 40 bar).
Die Mengenangaben in nachfolgenden Beispielen beziehen sich, soweit nicht anders angegeben, auf Gew. -% Aktivsubstanz der Gesamtzusammensetzung ohne Treibgas. Unless otherwise stated, the amounts in the following examples relate to% by weight of active substance of the total composition without propellant.
Beispiel 1 (Zusammensetzung ohne Treibgas)Example 1 (composition without propellant)
12,0 Gew.-% Silica (z. B. Sident® 8)12.0% by weight of silica (e.g. Sident ® 8)
60,0 Gew.-% Sorbitol (z. B. Neosorb® 70/70 B; 70 Gew.-% in Wasser)60.0% by weight of sorbitol (e.g. Neosorb ® 70/70 B; 70% by weight in water)
1 ,2 Gew.-% Natriumlaurylsulfat (z. B. Texapon® K 1296)1.2% by weight sodium lauryl sulfate (e.g. Texapon ® K 1296)
1,0 Gew.-% Cocamidopropylbetain (z. B. Tego-Betain® BL 215; 30 Gew.-% in Wasser)1.0% by weight cocamidopropylbetaine (e.g. Tego-Betain ® BL 215; 30% by weight in water)
0,5 Gew.-% PEG-30-Glycerylstearat (z. B. Tagat® S)0.5% by weight of PEG-30 glyceryl stearate (e.g. Tagat ® S)
3,0 Gew.-% Bienenwachs (z. B. Bienenwachs Typ 8100 DAB)3.0% by weight beeswax (e.g. beeswax type 8100 DAB)
1,0 Gew.-% Polyethylenglykol MG = 1550 (z. B. Polywachs® 1550)1.0% by weight polyethylene glycol MG = 1550 (e.g. Polywachs ® 1550)
0,55 Gew.-% Carboxymethylcellulose (z. B. Cekol® 2000 H)0.55% by weight carboxymethyl cellulose (e.g. Cekol ® 2000 H)
0,2 Gew.-% Na2HPO4 0.2% by weight Na 2 HPO 4
0,32 Gew.-% NaF0.32 wt% NaF
0,21 Gew.-% MgSO4 • 7 H2O0.21 wt% MgSO 4 • 7 H 2 O
0,09 Gew.-% ZnSO4 • 7 H2O0.09 wt% ZnSO 4 • 7 H 2 O
0,01 Gew.-% MnSO4 • 1 H2O0.01% by weight MnSO 4 • 1 H 2 O
0,2 Gew.-% Natriumsaccharinat0.2% by weight sodium saccharinate
0,49 Gew,-% Natriumbenzoat0.49% by weight sodium benzoate
2.0 Gew.-% Ethanol2.0% by weight of ethanol
0,2 Gew.-% Triclosan (z. B. Irgacare® MP)0.2% by weight triclosan (e.g. Irgacare ® MP)
0,1 Gew.-% Farbstofflösung (z. B. Brillant Blue FCF, 1 Gew.-% in Wasser)0.1% by weight dye solution (e.g. Brillant Blue FCF, 1% by weight in water)
1.1 Gew. -% Aromaöl ad 100 Gew.-% Wasser VE1.1% by weight of aromatic oil to 100% by weight of water VE
94 Gew.-% Zahnpastamasse wurden mit 6 Gew.-% eines 3:1-Gemisches (Gewichtsanteile) aus Isopentan und Isobutan in eine Zweikammer- Aerosoldose abgefüllt. Beispiel 2 (Zusammensetzung ohne Treibgas)94 wt .-% toothpaste was filled with 6 wt .-% of a 3: 1 mixture (parts by weight) of isopentane and isobutane in a two-chamber aerosol can. Example 2 (composition without propellant)
12,0 Gew.-% Silica (z. B. Sident® 8)12.0% by weight of silica (e.g. Sident ® 8)
30,0 Gew.-% Sorbitol (z. B. Neosorb® 70/70 B; 70 Gew.-% in Wasser)30.0% by weight of sorbitol (e.g. Neosorb ® 70/70 B; 70% by weight in water)
33,0 Gew.-% Glycerin (86 Gew.-% in Wasser)33.0% by weight glycerin (86% by weight in water)
1 ,5 Gew.-% Natriumlaurylsulfat (z. B. Texapon® K 1296)1.5% by weight sodium lauryl sulfate (e.g. Texapon ® K 1296)
0,6 Gew.-% Cocamidopropylbetain (z. B. Tego-Betain® BL 215, 30 Gew.-% in Wasser)0.6% by weight cocamidopropyl betaine (e.g. Tego-Betain ® BL 215, 30% by weight in water)
0,5 Gew.-% PEG-30-Glycerylstearat (z. B. Tagat® S)0.5% by weight of PEG-30 glyceryl stearate (e.g. Tagat ® S)
1,0 Gew.-% Paraffinöl, dünnflüssig (z. B. Paraffinum perliquidum P 130)1.0% by weight paraffin oil, low viscosity (e.g. Paraffinum perliquidum P 130)
1,0 Gew.-% Polyethylenglykol MG = 1550 (z. B. Polywachs® 1550)1.0% by weight polyethylene glycol MG = 1550 (e.g. Polywachs ® 1550)
0,55 Gew.-% Xanthan gum (z. B. Keltrol ® F)0.55% by weight xanthan gum (e.g. Keltrol ® F)
0,5 Gew.-% Na2HPO4 0.5% by weight Na 2 HPO 4
0,32 Gew.-%NaF0.32 wt% NaF
0,21 Gew.-% MgSO4 • 7 H2O0.21 wt% MgSO 4 • 7 H 2 O
0,09 Gew.-% ZnSO4 • 7 H2O0.09 wt% ZnSO 4 • 7 H 2 O
0,01 Gew.-% MnSO4 • 1 H2O0.01% by weight MnSO 4 • 1 H 2 O
0,2 Gew.-% Natriumsaccharinat0.2% by weight sodium saccharinate
0,49 Gew,-% Natriumbenzoat0.49% by weight sodium benzoate
2.0 Gew.-% Ethanol2.0% by weight of ethanol
0,2 Gew.-% Triclosan (z. B. Irgacare® MP)0.2% by weight triclosan (e.g. Irgacare ® MP)
0, 1 Gew.-% Farbstofflösung (z. B. Brillant Blue FCF, 1 Gew.-% in Wasser)0.1% by weight of dye solution (e.g. brilliant blue FCF, 1% by weight in water)
1.1 Gew. -% Aromaöl ad 100 Gew.-% Wasser VE1.1% by weight of aromatic oil to 100% by weight of water VE
96 Gew.-% Zahnpastamasse wurden mit 4 Gew.-% eines 3:1-Gemisches (Gewichtsanteile) aus Isopentan und Isobutan in eine Zweikammer- Aerosoldose abgefüllt. Beispiel 3 (Zusammensetzung ohne Treibgas)96% by weight of toothpaste was filled into a two-chamber aerosol can with 4% by weight of a 3: 1 mixture (parts by weight) of isopentane and isobutane. Example 3 (composition without propellant)
12,0 Gew.-% Silica (z. B. Sident® 8)12.0% by weight of silica (e.g. Sident ® 8)
46,0 Gew.-% Sorbitol (z. B. Neosorb® 70/70 B; 70 Gew.-% in Wasser)46.0% by weight of sorbitol (e.g. Neosorb ® 70/70 B; 70% by weight in water)
10,0 Gew.-% Xylitol10.0% by weight of xylitol
1 ,2 Gew.-% Natriumlaurylsulfat (z. B . Texapon® K 1296)1.2% by weight sodium lauryl sulfate (e.g. Texapon ® K 1296)
1,0 Gew.-% Cocamidopropylbetain (z. B. Tego-Betain® BL 215; 30 Gew.-% in Wasser)1.0% by weight cocamidopropylbetaine (e.g. Tego-Betain ® BL 215; 30% by weight in water)
0,5 Gew.-% PEG-30-Glycerylstearat (z. B. Tagat® S)0.5% by weight of PEG-30 glyceryl stearate (e.g. Tagat ® S)
3,0 Gew.-% Bienenwachs (z. B. Bienenwachs Typ 8100 DAB)3.0% by weight beeswax (e.g. beeswax type 8100 DAB)
1,0 Gew.-% Polyethylenglykol MG = 1550 (z. B. Polywachs® 1550)1.0% by weight polyethylene glycol MG = 1550 (e.g. Polywachs ® 1550)
0,55 Gew.-% Carboxymethylcellulose (z. B. Cekol® 2000 H)0.55% by weight carboxymethyl cellulose (e.g. Cekol ® 2000 H)
0,2 Gew.-% Na2HPO4 0.2% by weight Na 2 HPO 4
0,32 Gew.-% NaF0.32 wt% NaF
0,21 Gew.-% MgSO4 • 7 H2O0.21 wt% MgSO 4 • 7 H 2 O
0,09 Gew.-% ZnSO4 • 7 H2O0.09 wt% ZnSO 4 • 7 H 2 O
0,01 Gew.-% MnSO4 • 1 H2O0.01% by weight MnSO 4 • 1 H 2 O
0,2 Gew.-% Natriumsaccharinat0.2% by weight sodium saccharinate
0,49 Gew,-% Natriumbenzoat0.49% by weight sodium benzoate
2.0 Gew.-% Ethanol2.0% by weight of ethanol
0,2 Gew.-% Triclosan (z. B. Irgacare® MP)0.2% by weight triclosan (e.g. Irgacare ® MP)
0,1 Gew.-% Farbstofflösung (z. B. Brillant Blue FCF, 1 Gew.-% in Wasser)0.1% by weight dye solution (e.g. Brillant Blue FCF, 1% by weight in water)
1.1 Gew. -% Aromaöl ad 100 Gew.-% Wasser VE1.1% by weight of aromatic oil to 100% by weight of water VE
95 Gew.-% Zahnpastamasse wurden mit 5 Gew.-% Butan in eine Zweikammer-Aerosoldose abgefüllt. Beispiel 4 (Zusammensetzung ohne Treibgas)95% by weight of toothpaste was filled into a two-chamber aerosol can with 5% by weight of butane. Example 4 (composition without propellant)
12,0 Gew.-% Silica (z. B. Sident® 8)12.0% by weight of silica (e.g. Sident ® 8)
16,0 Gew.-% Sorbitol (z. B. Neosorb® 70/70 B; 70 Gew.-% in Wasser)16.0% by weight of sorbitol (e.g. Neosorb ® 70/70 B; 70% by weight in water)
10,0 Gew.-% Xylitol10.0% by weight of xylitol
33,0 Gew.-% Glycerin (86 Gew.-% in Wasser)33.0% by weight glycerin (86% by weight in water)
1 ,5 Gew.-% Natriumlaurylsulfat (z. B. Texapon® K 1296)1.5% by weight sodium lauryl sulfate (e.g. Texapon ® K 1296)
0,6 Gew.-% Cocamidopropylbetain (z. B. Tego-Betain® BL 215; 30 Gew.-% in Wasser)0.6% by weight cocamidopropylbetaine (e.g. Tego-Betain ® BL 215; 30% by weight in water)
0,5 Gew.-% PEG-30-Glycerylstearat (z. B. Tagat® S)0.5% by weight of PEG-30 glyceryl stearate (e.g. Tagat ® S)
1,0 Gew.-% Paraffinöl (z. B. Paraffinum perliquidum P 130)1.0% by weight paraffin oil (e.g. Paraffinum perliquidum P 130)
1 ,0 Gew.-% Polyethylenglykol MG = 1550 (z. B. Polywachs® 1550)1.0% by weight polyethylene glycol MG = 1550 (e.g. Polywachs ® 1550)
0,55 Gew.-% Xanthan gum (z. B. Keltrol ® F)0.55% by weight xanthan gum (e.g. Keltrol ® F)
0,5 Gew.-% Na2HPO4 0.5% by weight Na 2 HPO 4
0,32 Gew.-% NaF0.32 wt% NaF
0,21 Gew.-% MgSO4 • 7 H2O0.21 wt% MgSO 4 • 7 H 2 O
0,09 Gew.-% ZnSO4 • 7 H2O0.09 wt% ZnSO 4 • 7 H 2 O
0,01 Gew.-% MnSO4 • 1 H2O0.01% by weight MnSO 4 • 1 H 2 O
0,2 Gew.-% Natriumsaccharinat0.2% by weight sodium saccharinate
0,49 Gew,-% Natriumbenzoat0.49% by weight sodium benzoate
2.0 Gew.-% Ethanol2.0% by weight of ethanol
0,2 Gew.-% Triclosan (z. B. Irgacare® MP)0.2% by weight triclosan (e.g. Irgacare ® MP)
0,1 Gew.-% Farbstofflösung (z. B. Brillant Blue FCF, 1 Gew.-% in Wasser)0.1% by weight dye solution (e.g. Brillant Blue FCF, 1% by weight in water)
1.1 Gew.-% Aromaöl ad 100 Gew.-% Wasser VE1.1% by weight of aromatic oil ad 100% by weight of water VE
97 Gew.-% Zahnpastamasse wurden mit 3 Gew.-% eines 3:1 -Gemisches (Gewichtsanteile) aus Isopentan und Isobutan in das Atmos™ Dispensing System von Exxel abgefüllt. Beispiel 5 (Zusammensetzung ohne Treibgas)97% by weight of toothpaste was filled with 3% by weight of a 3: 1 mixture (parts by weight) of isopentane and isobutane in the Atmos ™ dispensing system from Exxel. Example 5 (composition without propellant)
12,0 Gew.-% Silica (z. B. Sident® 8)12.0% by weight of silica (e.g. Sident ® 8)
30,0 Gew.-% Sorbitol (z. B. Neosorb® 70/70 B; 70 Gew.-% in Wasser)30.0% by weight of sorbitol (e.g. Neosorb ® 70/70 B; 70% by weight in water)
33,0 Gew.-% Glycerin (86 Gew.-% in Wasser)33.0% by weight glycerin (86% by weight in water)
1,5 Gew.-% Natriumlaurylsulfat (z. B. Texapon® K 1296)1.5% by weight sodium lauryl sulfate (e.g. Texapon ® K 1296)
0,6 Gew.-% Cocamidopropylbetain (z. B. Tego-Betain® BL 215; 30 Gew.-% in Wasser)0.6% by weight cocamidopropylbetaine (e.g. Tego-Betain ® BL 215; 30% by weight in water)
0,5 Gew.-% PEG-30-Glycerylstearat (z. B. Tagat® S)0.5% by weight of PEG-30 glyceryl stearate (e.g. Tagat ® S)
1,0 Gew.-% Jojobaöl1.0% by weight jojoba oil
1,0 Gew.-% Polyethylenglykol MG = 1550 (z. B. Polywachs® 1550)1.0% by weight polyethylene glycol MG = 1550 (e.g. Polywachs ® 1550)
0,55 Gew.-% Xanthan gum (z. B. Keltrol ® F)0.55% by weight xanthan gum (e.g. Keltrol ® F)
0,5 Gew.-% Na2HPO4 0.5% by weight Na 2 HPO 4
0,32 Gew.-% NaF0.32 wt% NaF
0,21 Gew.-% MgSO4 • 7 H2O0.21 wt% MgSO 4 • 7 H 2 O
0,09 Gew.-% ZnSO4 • 7 H2O0.09 wt% ZnSO 4 • 7 H 2 O
0,01 Gew.-% MnSO4 • 1 H2O0.01% by weight MnSO 4 • 1 H 2 O
0,2 Gew.-% Natriumsaccharinat0.2% by weight sodium saccharinate
0,49 Gew,-% Natriumbenzoat0.49% by weight sodium benzoate
2.0 Gew.-% Ethanol2.0% by weight of ethanol
0,2 Gew.-% Triclosan (z. B. Irgacare® MP)0.2% by weight triclosan (e.g. Irgacare ® MP)
0,1 Gew.-% Farbstofflösung (z. B. Brillant Blue FCF, 1 Gew.-% in Wasser)0.1% by weight dye solution (e.g. Brillant Blue FCF, 1% by weight in water)
1.1 Gew. -% Aromaöl ad 100 Gew.-% Wasser VE1.1% by weight of aromatic oil to 100% by weight of water VE
98 Gew.-% Zahnpastamasse wurden mit 2 Gew.-% eines 3:1-Gemisches (Gewichtsanteile) aus Isopentan und Isobutan in das Atmos™ Dispensing System von Exxel abgefüllt. Beispiel 6 (Zusammensetzung ohne Treibgas)98% by weight of toothpaste was filled with 2% by weight of a 3: 1 mixture (parts by weight) of isopentane and isobutane in the Atmos ™ dispensing system from Exxel. Example 6 (composition without propellant)
12,0 Gew.-% Silica (z. B. Sident® 8)12.0% by weight of silica (e.g. Sident ® 8)
30,0 Gew.-% Sorbitol (z. B. Neosorb® 70/70 B; 70 Gew.-% in Wasser)30.0% by weight of sorbitol (e.g. Neosorb ® 70/70 B; 70% by weight in water)
33,0 Gew.-% Glycerin (86 Gew.-% in Wasser)33.0% by weight glycerin (86% by weight in water)
1,5 Gew.-% Natriumlaurylsulfat (z. B. Texapon® K 1296)1.5% by weight sodium lauryl sulfate (e.g. Texapon ® K 1296)
0,6 Gew.-% Cocamidopropylbetain (z. B. Tego-Betain® BL 215; 30 Gew.-% in Wasser)0.6% by weight cocamidopropylbetaine (e.g. Tego-Betain ® BL 215; 30% by weight in water)
0,5 Gew.-% PEG-30-Glycerylstearat (z. B. Tagat® S)0.5% by weight of PEG-30 glyceryl stearate (e.g. Tagat ® S)
1 ,0 Gew.-% Paraffinöl, dickflüssig (z. B. BP-Energol® WM-6)1.0% by weight paraffin oil, viscous (e.g. BP-Energol ® WM-6)
1 ,0 Gew.-% Polyethylenglykol MG = 1550 (z. B. Polywachs® 1550)1.0% by weight polyethylene glycol MG = 1550 (e.g. Polywachs ® 1550)
0,55 Gew.-% Carboxymethylcellulose (z. B. Cekol ® 2000H)0.55% by weight carboxymethyl cellulose (e.g. Cekol ® 2000H)
0,5 Gew.-% Na2HPO4 0.5% by weight Na 2 HPO 4
0,32 Gew.-% NaF0.32 wt% NaF
0,21 Gew.-% MgSO4 • 7 H2O0.21 wt% MgSO 4 • 7 H 2 O
0,09 Gew.-% ZnSO4 • 7 H2O0.09 wt% ZnSO 4 • 7 H 2 O
0,01 Gew.-% MnSO4 • 1 H2O0.01% by weight MnSO 4 • 1 H 2 O
0,2 Gew.-% Natriumsaccharinat0.2% by weight sodium saccharinate
0,49 Gew,-% Natriumbenzoat0.49% by weight sodium benzoate
2.0 Gew.-% Ethanol2.0% by weight of ethanol
0,2 Gew.-% Triclosan (z. B. Irgacare® MP)0.2% by weight triclosan (e.g. Irgacare ® MP)
0, 1 Gew.-% Farbstofflösung (z. B. Brillant Blue FCF, 1 Gew.-% in Wasser)0.1% by weight of dye solution (e.g. brilliant blue FCF, 1% by weight in water)
1.1 Gew. -% Aromaöl ad 100 Gew.-% Wasser VE1.1% by weight of aromatic oil to 100% by weight of water VE
97 Gew.-% Zahnpastamasse wurden mit 3 Gew.-% eines 3:1-Gemisches (Gewichtsanteile) aus Isopentan und Isobutan in eine Zweikammer- Aerosoldose abgefüllt. Beispiel 7 (Zusammensetzung ohne Treibgas)97% by weight of toothpaste was filled into a two-chamber aerosol can with 3% by weight of a 3: 1 mixture (parts by weight) of isopentane and isobutane. Example 7 (composition without propellant)
12,0 Gew.-% Silica (z. B. Sident® 8)12.0% by weight of silica (e.g. Sident ® 8)
30,0 Gew.-% Sorbitol (z. B. Neosorb® 70/70 B; 70 Gew.-% in Wasser)30.0% by weight of sorbitol (e.g. Neosorb ® 70/70 B; 70% by weight in water)
33,0 Gew.-% Glycerin (86 Gew.-% in Wasser)33.0% by weight glycerin (86% by weight in water)
1 ,5 Gew.-% Natriumlaurylsulfat (z. B. Texapon® K 1296)1.5% by weight sodium lauryl sulfate (e.g. Texapon ® K 1296)
0,6 Gew.-% Cocamidopropylbetain (z. B. Tego-Betain® BL 215; 30 Gew.-% in Wasser)0.6% by weight cocamidopropylbetaine (e.g. Tego-Betain ® BL 215; 30% by weight in water)
0,5 Gew.-% PEG-30-Glycerylstearat (z. B. Tagat® S)0.5% by weight of PEG-30 glyceryl stearate (e.g. Tagat ® S)
1 ,0 Gew.-% Paraffinöl, dickflüssig (z. B. BP-Energol® WM-6)1.0% by weight paraffin oil, viscous (e.g. BP-Energol ® WM-6)
0,25 Gew.-% Glycerinmonostearat (z. B. Cutina® GMS-V)0.25% by weight glycerol monostearate (e.g. Cutina ® GMS-V)
1 ,0 Gew.-% Polyethylenglykol MG = 1550 (z. B. Polywachs® 1550)1.0% by weight polyethylene glycol MG = 1550 (e.g. Polywachs ® 1550)
0,45 Gew.-% Xanthan gum (z. B. Keltrol ® F)0.45% by weight xanthan gum (e.g. Keltrol ® F)
0,5 Gew.-% Na2HPO4 0.5% by weight Na 2 HPO 4
0,32 Gew.-% NaF0.32 wt% NaF
0,21 Gew.-% MgSO4 • 7 H2O0.21 wt% MgSO 4 • 7 H 2 O
0,09 Gew.-% ZnSO4 • 7 H2O0.09 wt% ZnSO 4 • 7 H 2 O
0,01 Gew.-% MnSO4 • 1 H2O0.01% by weight MnSO 4 • 1 H 2 O
0,2 Gew.-% Natriumsaccharinat0.2% by weight sodium saccharinate
0,49 Gew,-% Natriumbenzoat0.49% by weight sodium benzoate
2.0 Gew.-% Ethanol2.0% by weight of ethanol
0,2 Gew.-% Triclosan (z. B. Irgacare® MP)0.2% by weight triclosan (e.g. Irgacare ® MP)
0,1 Gew.-% Farbstofflösung (z. B. Brillant Blue FCF, 1 Gew.-% in Wasser)0.1% by weight dye solution (e.g. Brillant Blue FCF, 1% by weight in water)
1.1 Gew. -% Aromaöl ad 100 Gew.-% Wasser VE1.1% by weight of aromatic oil to 100% by weight of water VE
96 Gew.-% Zahnpastamasse wurden mit 4 Gew.-% eines 3:1-Gemisches (Gewichtsanteile) aus Isopentan und Isobutan in das Atmos™ Dispensing System von Exxel abgefüllt. Beispiel 8 (Zusammensetzung ohne Treibgas)96% by weight of toothpaste was filled with 4% by weight of a 3: 1 mixture (parts by weight) of isopentane and isobutane in the Atmos ™ dispensing system from Exxel. Example 8 (composition without propellant)
12,0 Gew.-% Silica (z. B. Sident® 8)12.0% by weight of silica (e.g. Sident ® 8)
30,0 Gew.-% Sorbitol (z. B. Neosorb® 70/70 B; 70 Gew.-% in Wasser)30.0% by weight of sorbitol (e.g. Neosorb ® 70/70 B; 70% by weight in water)
33,0 Gew.-% Glycerin (86 Gew.-% in Wasser)33.0% by weight glycerin (86% by weight in water)
1 ,5 Gew.-% Natriumlaurylsulfat (z. B. Texapon® K 1296)1.5% by weight sodium lauryl sulfate (e.g. Texapon ® K 1296)
0,6 Gew.-% Cocamidopropylbetain (z. B. Tego-Betain® BL 215; 30 Gew.-% in Wasser)0.6% by weight cocamidopropylbetaine (e.g. Tego-Betain ® BL 215; 30% by weight in water)
0,5 Gew.-% PEG-30-Glycerylstearat (z. B. Tagat® S)0.5% by weight of PEG-30 glyceryl stearate (e.g. Tagat ® S)
1 ,0 Gew.-% Paraffinöl, dickflüssig (z. B. BP-Energol® WM-6)1.0% by weight paraffin oil, viscous (e.g. BP-Energol ® WM-6)
0,35 Gew.-% Glycerinmonostearat (z. B. Cutina® GMS-V)0.35% by weight glycerol monostearate (e.g. Cutina ® GMS-V)
1,0 Gew.-% Polyethylenglykol MG = 1550 (z. B. Polywachs® 1550)1.0% by weight polyethylene glycol MG = 1550 (e.g. Polywachs ® 1550)
0,45 Gew.-% Xanthan gum (z. B. Keltrol ® F)0.45% by weight xanthan gum (e.g. Keltrol ® F)
0,5 Gew.-% Na2HPO4 0.5% by weight Na 2 HPO 4
0,32 Gew.-% NaF0.32 wt% NaF
0,21 Gew.-% MgSO4 • 7 H2O0.21 wt% MgSO 4 • 7 H 2 O
0,09 Gew.-% ZnSO4 • 7 H2O0.09 wt% ZnSO 4 • 7 H 2 O
0,01 Gew.-% MnSO4 • 1 H2O0.01% by weight MnSO 4 • 1 H 2 O
0,2 Gew.-% Natriumsaccharinat0.2% by weight sodium saccharinate
0,49 Gew,-% Natriumbenzoat0.49% by weight sodium benzoate
2.0 Gew.-% Ethanol2.0% by weight of ethanol
0,2 Gew.-% Triclosan (z. B. Irgacare® MP)0.2% by weight triclosan (e.g. Irgacare ® MP)
0,1 Gew.-% Farbstofflösung (z. B. Brillant Blue FCF, 1 Gew.-% in Wasser)0.1% by weight dye solution (e.g. Brillant Blue FCF, 1% by weight in water)
1.1 Gew.-% Aromaöl ad 100 Gew.-% Wasser VE1.1% by weight of aromatic oil ad 100% by weight of water VE
95 Gew.-% Zahnpastamasse wurden mit 5 Gew.-% Butan in das eine Zweikammer- Aerosoldose abgefüllt. Beispiel 9 (Zusammensetzung ohne Treibgas)95% by weight of toothpaste was filled into a two-chamber aerosol can with 5% by weight of butane. Example 9 (composition without propellant)
12,0 Gew.-% Süica (z. B. Sident® 8)12.0% by weight of Süica (e.g. Sident ® 8)
60,0 Gew.-% Sorbitol (z. B. Neosorb® 70/70 B; 70 Gew.-% in Wasser)60.0% by weight of sorbitol (e.g. Neosorb ® 70/70 B; 70% by weight in water)
1 ,5 Gew.-% Natriumlaurylsulfat (z. B. Texapon® K 1296)1.5% by weight sodium lauryl sulfate (e.g. Texapon ® K 1296)
0,6 Gew.-% Cocamidopropylbetain (z. B . Tego-Betain® BL 215 ; 30 Gew.-% in Wasser)0.6% by weight cocamidopropylbetaine (e.g. Tego-Betain ® BL 215; 30% by weight in water)
0,5 Gew.-% PEG-30-Glycerylstearat (z. B. Tagat® S)0.5% by weight of PEG-30 glyceryl stearate (e.g. Tagat ® S)
1,0 Gew.-% Jojobaöl1.0% by weight jojoba oil
1 ,5 Gew.-% Polyethylenglykol MG = 1550 (z. B. Polywachs® 1550)1.5% by weight of polyethylene glycol MG = 1550 (e.g. Polywachs ® 1550)
1 ,0 Gew.-% Cellulose (z. B. Arbocel® CGP 5000; 5 Gew.-% in Wasser)1.0% by weight cellulose (e.g. Arbocel ® CGP 5000; 5% by weight in water)
0,55 Gew.-% Xanthan gum (z. B. Keltrol ® F)0.55% by weight xanthan gum (e.g. Keltrol ® F)
0,2 Gew.-% Na2HPO4 0.2% by weight Na 2 HPO 4
0,32 Gew.-% NaF0.32 wt% NaF
0,2 Gew.-% Natriumsaccharinat0.2% by weight sodium saccharinate
0,49 Gew,-% Natriumbenzoat0.49% by weight sodium benzoate
0, 1 Gew.-% Triclosan (z. B. Irgacare® MP)0.1% by weight triclosan (e.g. Irgacare ® MP)
0,26 Gew.-% Farbstofflösung (z. B. Kombination aus: Brillant Blue FCF, 1 Gew.-% in0.26% by weight of dye solution (e.g. combination of: Brillant Blue FCF, 1% by weight in
Wasser und Schwarz CI 27755, 0,1 Gew.-% in Wasser)Water and black CI 27755, 0.1% by weight in water)
1,0 Gew.-% Aromaöl ad 100 Gew.-% Wasser VE1.0% by weight of aromatic oil ad 100% by weight of water VE
97 Gew.-% Zahnpastamasse wurden mit 3 Gew.-% eines 3:1-Gemisches (Gewichtsanteile) aus Isopentan und Isobutan in das Atmos™ Dispensing System von Exxel abgefüllt. 97% by weight of toothpaste was filled with 3% by weight of a 3: 1 mixture (parts by weight) of isopentane and isobutane in the Atmos ™ dispensing system from Exxel.
Beispiel 10 (Zusammensetzung ohne Treibgas)Example 10 (composition without propellant)
12,0 Gew.-% Silica (z. B. Sident® 8)12.0% by weight of silica (e.g. Sident ® 8)
0,5 Gew.-% Schichtsilikat (z. B. Laponite® DF)0.5% by weight layered silicate (e.g. Laponite ® DF)
60,0 Gew.-% Sorbitol (z. B. Neosorb® 70/70 B; 70 Gew.-% in Wasser)60.0% by weight of sorbitol (e.g. Neosorb ® 70/70 B; 70% by weight in water)
1 ,5 Gew.-% Natriumlaurylsulfat (z. B . Texapon® K 1296)1.5% by weight sodium lauryl sulfate (e.g. Texapon ® K 1296)
0,6 Gew.-% Cocamidopropylbetain (z. B. Tego-Betain® BL 215; 30 Gew.-% in Wasser)0.6% by weight cocamidopropylbetaine (e.g. Tego-Betain ® BL 215; 30% by weight in water)
0,5 Gew.-% PEG-30-Glycerylstearat (z. B. Tagat® S)0.5% by weight of PEG-30 glyceryl stearate (e.g. Tagat ® S)
1,0 Gew.-% Jojobaöl1.0% by weight jojoba oil
1 ,5 Gew.-% Polyethylenglykol MG = 1550 (z. B. Polywachs® 1550)1.5% by weight of polyethylene glycol MG = 1550 (e.g. Polywachs ® 1550)
0,55 Gew.-% Xanthan gum (z. B. Keltrol ® F)0.55% by weight xanthan gum (e.g. Keltrol ® F)
0,2 Gew.-% Na2HPO4 0.2% by weight Na 2 HPO 4
0,32 Gew.-% NaF0.32 wt% NaF
0,2 Gew.-% Natriumsaccharinat0.2% by weight sodium saccharinate
0,49 Gew,-% Natriumbenzoat0.49% by weight sodium benzoate
0,1 Gew.-% Triclosan (z. B. Irgacare® MP)0.1% by weight triclosan (e.g. Irgacare ® MP)
0,26 Gew.-% Farbstofflösung (z. B. Kombination aus: Brillant Blue FCF, 1 Gew.-% in0.26% by weight of dye solution (e.g. combination of: Brillant Blue FCF, 1% by weight in
Wasser und Schwarz CI 27755, 0,1 Gew.-% in Wasser) 1,0 Gew.-% Aromaöl ad 100 Gew.-% Wasser VEWater and black CI 27755, 0.1% by weight in water) 1.0% by weight aromatic oil ad 100% by weight water VE
95 Gew.-% Zahnpastamasse wurden mit 5 Gew.-% eines 3:1-Gemisches (Gewichtsanteile) aus Isopentan und Isobutan in das Atmos™ Dispensing System von Exxel abgefüllt. 95% by weight of toothpaste was filled with 5% by weight of a 3: 1 mixture (parts by weight) of isopentane and isobutane in Exxel's Atmos ™ dispensing system.
Beispiel 11 (Zusammensetzung ohne Treibgas)Example 11 (composition without propellant)
12,0 Gew.-% Silica (z. B. Sident® 8)12.0% by weight of silica (e.g. Sident ® 8)
60,0 Gew.-% Sorbitol (z. B. Neosorb® 70/70 B; 70 Gew.-% in Wasser)60.0% by weight of sorbitol (e.g. Neosorb ® 70/70 B; 70% by weight in water)
1 ,5 Gew.-% Natriumlaurylsulfat (z. B. Texapon® K 1296)1.5% by weight sodium lauryl sulfate (e.g. Texapon ® K 1296)
0,6 Gew.-% Cocamidopropylbetain (z. B. Tego-Betain® BL 215; 30 Gew.-% in Wasser)0.6% by weight cocamidopropylbetaine (e.g. Tego-Betain ® BL 215; 30% by weight in water)
0,5 Gew.-% PEG-30-Glycerylstearat (z. B. Tagat® S)0.5% by weight of PEG-30 glyceryl stearate (e.g. Tagat ® S)
1,0 Gew.-% Jojobaöl1.0% by weight jojoba oil
1 ,0 Gew.-% Cellulose (z. B. Arbocel® CGP 5000; 5 Gew.-% in Wasser)1.0% by weight cellulose (e.g. Arbocel ® CGP 5000; 5% by weight in water)
0,65 Gew.-% Xanthan gum (z. B. Keltrol ® F)0.65% by weight xanthan gum (e.g. Keltrol ® F)
1,5 Gew.-% Polyethylenglykol MG = 1550 (z. B. Polywachs® 1550)1.5% by weight of polyethylene glycol MG = 1550 (e.g. Polywachs ® 1550)
0,2 Gew.-% Na2HPO4 0.2% by weight Na 2 HPO 4
0,32 Gew.-% NaF0.32 wt% NaF
0,2 Gew.-% Natriumsaccharinat0.2% by weight sodium saccharinate
0,49 Gew,-% Natriumbenzoat0.49% by weight sodium benzoate
0, 1 Gew.-% Triclosan (z. B. Irgacare® MP)0.1% by weight triclosan (e.g. Irgacare ® MP)
0,26 Gew.-% Farbstofflösung (z. B. Kombination aus: Brillant Blue FCF, 1 Gew.-% in0.26% by weight of dye solution (e.g. combination of: Brillant Blue FCF, 1% by weight in
Wasser und Schwarz CI 27755, 0,1 Gew.-% in Wasser)Water and black CI 27755, 0.1% by weight in water)
1,0 Gew.-% Aromaöl ad 100 Gew.-% Wasser VE1.0% by weight of aromatic oil ad 100% by weight of water VE
98 Gew.-% Zahnpastamasse wurden mit 2 Gew.-% eines 3:1-Gemisches (Gewichtsanteile) aus Isopentan und Isobutan in das Atmos™ Dispensing System von Exxel abgefüllt. 98% by weight of toothpaste was filled with 2% by weight of a 3: 1 mixture (parts by weight) of isopentane and isobutane in the Atmos ™ dispensing system from Exxel.
Anhang ) Arbocel® CGP 5000 Cellulose-Paste (5 Gew.-% in Wasser) Hersteller: J. Rettenmaier & Söhne GmbH + CO ) Bienenwachs Typ 8100 DAB INCI: Cera alba Hersteller: Kahl & Co ) Brilliant Blue® FCFAppendix) Arbocel ® CGP 5000 cellulose paste (5% by weight in water) manufacturer: J. Rettenmaier & Söhne GmbH + CO) beeswax type 8100 DAB INCI: Cera alba manufacturer: Kahl & Co) Brilliant Blue ® FCF
INCI: Acid blue 9/ CI 42090INCI: Acid blue 9 / CI 42090
Hersteller: Fiorio Colori S.p.A. (Pharmorgana) ) BP-Energol® WM-6 Paraffinöl, dickflüssig Hersteller: BP ) Cekol®2000 HManufacturer: Fiorio Colori SpA (Pharmorgana)) BP-Energol ® WM-6 paraffin oil, viscous Manufacturer: BP) Cekol ® 2000 H
INCI: Cellulose (Na-Carboxymethylcellulose) Hersteller: Metsa (Nordmann Rassmann) ) Cutina® GMS-V INCI: Glyceryl stearateINCI: Cellulose (Na-Carboxymethylcellulose) Manufacturer: Metsa (Nordmann Rassmann)) Cutina ® GMS-V INCI: Glyceryl stearate
Hersteller: Cognis Deutschland GmbH (Henkel) ) Irgacare® MP INCI: Triclosan Hersteller: Ciba ) Keltrol® FManufacturer: Cognis Deutschland GmbH (Henkel)) Irgacare ® MP INCI: Triclosan Manufacturer: Ciba ) Keltrol ® F
INCI: Xanthan Gum Hersteller: Kelco ) Laponite® DS Natrium-Magnesium-Lithium-Schichtsilikat Hersteller: Laporte 0)Neosorb® 70/70 BINCI: Xanthan Gum Manufacturer: Kelco) Laponite ® DS Sodium Magnesium Lithium Layer Silicate Manufacturer: Laporte 0) Neosorb ® 70/70 B
INCI: Sorbitol (70 Gew.-% in Wasser) Hersteller: Roquette 1) Paraffinum perliquidum P 130INCI: Sorbitol (70% by weight in water) Manufacturer: Roquette 1) Paraffinum perliquidum P 130
Paraffinöl, Viskosität: 17 mmVs nach DIN 51562/1 Hersteller: Parafluid Mineralölgesellschaft 2)Polywachs® 1550Paraffin oil, viscosity: 17 mmVs according to DIN 51562/1 Manufacturer: Parafluid Mineralölgesellschaft 2) Polywachs ® 1550
Polyethylenglykol, MG = 1550Polyethylene glycol, MW = 1550
Hersteller: RWE/DEA (Contensio, ehemals Hüls) 3) Sident® 8Manufacturer: RWE / DEA (Contensio, formerly Hüls) 3) Sident ® 8
INCI: Hydrated silica Hersteller: Degussa-Hüls 4) Tagat® SINCI: Hydrated silica Manufacturer: Degussa-Hüls 4) Tagat ® S
INCI: PEG-30 Glyceryl Stearate Hersteller: Goldschmidt 5) Tego-Betain® BL 215 (30 Gew.-% in Wasser) INCI: Cocamidopropyl betaine Hersteller: Goldschmidt )Texapon®K1296INCI: PEG-30 Glyceryl Stearate Manufacturer: Goldschmidt 5) Tego-Betain ® BL 215 (30% by weight in water) INCI: Cocamidopropyl betaine Manufacturer: Goldschmidt ) Texapon ® K1296
INCI: Sodium lauryl sulfateINCI: sodium lauryl sulfate
Hersteller: Cognis Deutschland GmbH (Henkel) Manufacturer: Cognis Deutschland GmbH (Henkel)

Claims

Patentansprücheclaims
Zahnreinigungsmittel enthaltend a) wenigstens ein Poliermittel b) wenigstens ein Feuchthaltemittel c) wenigstens ein Tensid d) wenigstens eine Öl/Fett- und/oder Wachskomponente dadurch gekennzeichnet, daß es mit einem Treibgas oder Treibgasgemisch in einem Spendersystem mit manuell betätigbarem Ventil abgefüllt ist.Dentifrice containing a) at least one polishing agent b) at least one humectant c) at least one surfactant d) at least one oil / fat and / or wax component, characterized in that it is filled with a propellant gas or propellant gas mixture in a dispenser system with a manually operable valve.
Zahnreinigungsmittel gemäß Anspruch 1, dadurch gekennzeichnet, daß das Poliermittel wenigstens eine Verbindung aus der Gruppe der Kieselsäuren oder Silikate enthält.Tooth cleaning agent according to claim 1, characterized in that the polishing agent contains at least one compound from the group of silicas or silicates.
Zahnreinigungsmittel gemäß Anspruch 1 oder 2, dadurch gekennzeichnet, daß als Feuchthaltemittel wenigstens Sorbitol, Glycerin oder Xylitol bzw. ein beliebiges Gemisch dieser Substanzen enthalten ist.Tooth cleaning agent according to claim 1 or 2, characterized in that at least sorbitol, glycerol or xylitol or any mixture of these substances is contained as a humectant.
Zahnreinigungsmittel gemäß einem der Ansprüche 1 bis 3, dadurch gekennzeichnet, daß das Tensid gewählt ist aus der Gruppe der Aniontenside, der zwitterionischen und Amphotenside und der Niotenside oder einem beliebigen Gemisch dieser Tenside.Tooth cleaning agent according to one of claims 1 to 3, characterized in that the surfactant is selected from the group of anionic surfactants, zwitterionic and amphoteric surfactants and nonionic surfactants or any mixture of these surfactants.
Zahnreinigungsmittel gemäß einem der Ansprüche 1 bis 4, dadurch gekennzeichnet, daß die Wachskomponente ausgewählt ist aus der Gruppe der pflanzlichen, der tierischen oder der Paraffinwachse bzw. einem beliebigen Gemisch dieser Wachse.Tooth cleaning agent according to one of claims 1 to 4, characterized in that the wax component is selected from the group of vegetable, animal or paraffin waxes or any mixture of these waxes.
Zahnreinigungsmittel gemäß einem der Ansprüche 1 bis 5, dadurch gekennzeichnet, daß die Ölkomponente ausgewählt ist aus der Gruppe der Paraffinöle oder der Triglyceride. Zahnreinigungsmittel gemäß einem der Ansprüche 1 bis 6, dadurch gekennzeichnet, daß das Treibgas ein C5-Alkan enthält.Dental cleaning agent according to one of claims 1 to 5, characterized in that the oil component is selected from the group of paraffin oils or triglycerides. Tooth cleaning agent according to one of claims 1 to 6, characterized in that the propellant gas contains a C 5 alkane.
Zahnreinigungsmittel gemäß einem der Ansprüche 1 bis 7, dadurch gekennzeichnet, daß das Treibgas ein Gemisch eines C4-Alkans und eines C5-Alkans enthält.Tooth cleaning agent according to one of claims 1 to 7, characterized in that the propellant gas contains a mixture of a C 4 alkane and a C 5 alkane.
Zahnreinigungsmittel gemäß einem der Ansprüche 1 bis 8, dadurch gekennzeichnet, daß es zusätzlich wenigstens ein Binde- oder Verdickungsmittel enthält.Tooth cleaning agent according to one of claims 1 to 8, characterized in that it additionally contains at least one binding or thickening agent.
Zahnreinigungsmittel gemäß Anspruch 9, dadurch gekennzeichnet, daß es als Bindeoder Verdickungsmittel wenigstens eine pulverförmige Cellulose enthält.Tooth cleaning agent according to claim 9, characterized in that it contains at least one powdered cellulose as binding or thickening agent.
Zahnreinigungsmittel gemäß einem der Ansprüche 1 bis 10, dadurch gekennzeichnet, daß es als zusätzliche Wirkstoffe Antikarieswirkstoffe, antimikrobielle Wirkstoffe, Zahnstein-Inhibitoren, Remineralisierungswirkstoffe, Geschmacksstoffe oder eine beliebige Kombination dieser Stoffe enthält.Tooth cleaning agent according to one of claims 1 to 10, characterized in that it contains anti-caries agents, antimicrobial agents, tartar inhibitors, remineralizing agents, flavoring agents or any combination of these substances as additional active ingredients.
Zahnreinigungsmittel gemäß einem der Ansprüche 1 bis 11, dadurch gekennzeichnet, daß es wenigstens 1 Gew.-% eines Treibgases oder eines Treibgasgemisches enthält.Tooth cleaning agent according to one of claims 1 to 11, characterized in that it contains at least 1% by weight of a propellant gas or a propellant gas mixture.
Zahnreinigungsmittel gemäß einem der Ansprüche 1 bis 12, dadurch gekennzeichnet, daß das Mittel ohne Treibgas bei 25 °C eine Viskosität von wenigstens 10000 mPa-s aufweist.Tooth cleaning agent according to one of claims 1 to 12, characterized in that the agent without propellant gas has a viscosity of at least 10000 mPa-s at 25 ° C.
Zahnreinigungsmittel gemäß einem der Ansprüche 1 bis 13, dadurch gekennzeichnet, daß es wenigstens a) 5 - 30 Gew.-% eines Poliermittels b) 20 - 85 Gew.-% eines Feuchthaltemittels c) 0,3 - 5 Gew.-% eines Tensids oder Tensidgemisches d) 0,1 - 40 Gew.-% eines Öls, Fetts und/oder Wachses e) 0,05 - 0,5 Gew.-% eines Fluorids f) 5 - 50 Gew.-% Wasser g) 1 - 10 Gew.-% eines C4- und/oder C5-haltigen Treibgases oder Treibgasgemisches in einem Spendersystem mit manuell betätigbarem Ventil enthält.Tooth cleaning agent according to one of claims 1 to 13, characterized in that it contains at least a) 5-30% by weight of a polishing agent b) 20-85% by weight of a humectant c) 0.3-5% by weight of a surfactant or surfactant mixture d) 0.1-40% by weight of an oil, fat and / or wax e) 0.05-0.5% by weight of a fluoride f) 5-50% by weight of water g) 1-10% by weight of a C 4 and / or C 5 -containing propellant gas or propellant gas mixture in a dispenser system with a manually operable valve.
Verwendung eines Zahnreinigungsmittel gemäß einem der Ansprüche 1 bis 14 zur Reinigung und Pflege der Zähne und zur Prävention von Zahn- und Zahnfleischerkrankungen.Use of a tooth cleaning agent according to one of claims 1 to 14 for cleaning and care of the teeth and for the prevention of tooth and gum diseases.
Verfahren zur Zahnpflege und -reinigung, dadurch gekennzeichnet, daß man aus einem Spendersystem durch manuelle Betätigung eines Ventils einen nicht oder nur wenig aufgeschäumten Zahnpastastrang auf einen zur mechanischen Reinigung der Zähne geeigneten Gegenstand aufbringt, wobei der Zahnpastastrang bei 20 °C und Normaldruck eine Expansionsrate von nicht mehr als 100 Vol.-% in 5 Sekunden aufweist und dann in einer Zeitspanne von 10 - 100 Sekunden auf nicht mehr als das 6-fache seines Volumens expandiert, und man das gashaltige Zahnpasta-Mousse zur Reinigung der Zahnoberflächen, Zahnzwischenräume und der Mundhöhle verwendet. Process for dental care and cleaning, characterized in that from a dispenser system, by manual actuation of a valve, a toothpaste strand that is not or only slightly foamed is applied to an object suitable for mechanical cleaning of the teeth, the toothpaste strand at 20 ° C. and normal pressure having an expansion rate of has not more than 100% by volume in 5 seconds and then expands to not more than 6 times its volume in a period of 10-100 seconds, and the gas-containing toothpaste mousse is used to clean the tooth surfaces, interdental spaces and the oral cavity used.
PCT/EP2001/001721 2000-02-25 2001-02-16 Dental cleaning agents containing propellant gas WO2001062209A2 (en)

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