WO2001062378A3 - Microarray fabrication techniques and apparatus - Google Patents

Microarray fabrication techniques and apparatus Download PDF

Info

Publication number
WO2001062378A3
WO2001062378A3 PCT/US2001/005844 US0105844W WO0162378A3 WO 2001062378 A3 WO2001062378 A3 WO 2001062378A3 US 0105844 W US0105844 W US 0105844W WO 0162378 A3 WO0162378 A3 WO 0162378A3
Authority
WO
WIPO (PCT)
Prior art keywords
capillaries
microarray
fabrication techniques
methods
bundles
Prior art date
Application number
PCT/US2001/005844
Other languages
French (fr)
Other versions
WO2001062378A2 (en
Inventor
Shiping Chen
Yuling Luo
Anthony C Chen
Original Assignee
Genospectra Inc
Shiping Chen
Yuling Luo
Anthony C Chen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genospectra Inc, Shiping Chen, Yuling Luo, Anthony C Chen filed Critical Genospectra Inc
Priority to CA002399189A priority Critical patent/CA2399189A1/en
Priority to AU62913/01A priority patent/AU6291301A/en
Priority to EP01937149A priority patent/EP1257355A2/en
Priority to JP2001561434A priority patent/JP2004502923A/en
Publication of WO2001062378A2 publication Critical patent/WO2001062378A2/en
Publication of WO2001062378A3 publication Critical patent/WO2001062378A3/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B01L3/0268—Drop counters; Drop formers using pulse dispensing or spraying, eg. inkjet type, piezo actuated ejection of droplets from capillaries
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B01L3/0262—Drop counters; Drop formers using touch-off at substrate or container
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/251—Colorimeters; Construction thereof
    • G01N21/253—Colorimeters; Construction thereof for batch operation, i.e. multisample apparatus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00364—Pipettes
    • B01J2219/00367—Pipettes capillary
    • B01J2219/00369—Pipettes capillary in multiple or parallel arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00382—Stamping
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00385—Printing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00418—Means for dispensing and evacuation of reagents using pressure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B01J2219/00529—DNA chips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00608—DNA chips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/0061—The surface being organic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00614—Delimitation of the attachment areas
    • B01J2219/00617—Delimitation of the attachment areas by chemical means
    • B01J2219/00619—Delimitation of the attachment areas by chemical means using hydrophilic or hydrophobic regions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00614—Delimitation of the attachment areas
    • B01J2219/00621—Delimitation of the attachment areas by physical means, e.g. trenches, raised areas
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623—Immobilisation or binding
    • B01J2219/00626—Covalent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00632—Introduction of reactive groups to the surface
    • B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00646—Making arrays on substantially continuous surfaces the compounds being bound to beads immobilised on the solid supports
    • B01J2219/00648—Making arrays on substantially continuous surfaces the compounds being bound to beads immobilised on the solid supports by the use of solid beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • B01J2219/00707—Processes involving means for analysing and characterising the products separated from the reactor apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00725—Peptides
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6484—Optical fibres
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1034—Transferring microquantities of liquid
    • G01N2035/1037—Using surface tension, e.g. pins or wires
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1065—Multiple transfer devices
    • G01N35/1074—Multiple transfer devices arranged in a two-dimensional array

Abstract

Disclosed is a microarray printing system and methods of printing probe microarrays 1000. The system has a print-head (102, 606, 706, 806) formed of one or more capillary bundle (104), such as light-guiding capillaries. The bundles (104) may especially be bundles (104) of capillaries that provide a large number of probes 1004 on the surface of a substrate. Methods of registering or correlating the distal 112 and proximal 110 ends of the capillaries are also provided. Further, the invention provides methods and equipment for identifying defective microarrays 1000 that are missing one or more probes from the surface of the microarray 1000.
PCT/US2001/005844 2000-02-22 2001-02-22 Microarray fabrication techniques and apparatus WO2001062378A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002399189A CA2399189A1 (en) 2000-02-22 2001-02-22 Microarray fabrication techniques and apparatus
AU62913/01A AU6291301A (en) 2000-02-22 2001-02-22 Microarray fabrication techniques and apparatus
EP01937149A EP1257355A2 (en) 2000-02-22 2001-02-22 Microarray fabrication techniques and apparatus
JP2001561434A JP2004502923A (en) 2000-02-22 2001-02-22 Microarray manufacturing method and manufacturing apparatus

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US18373700P 2000-02-22 2000-02-22
US60/183,737 2000-02-22
US18887200P 2000-03-13 2000-03-13
US60/188,872 2000-03-13
US21626500P 2000-07-06 2000-07-06
US60/216,265 2000-07-06
US22008500P 2000-07-21 2000-07-21
US60/220,085 2000-07-21
US24441300P 2000-10-30 2000-10-30
US60/244,413 2000-10-30

Publications (2)

Publication Number Publication Date
WO2001062378A2 WO2001062378A2 (en) 2001-08-30
WO2001062378A3 true WO2001062378A3 (en) 2002-02-07

Family

ID=27539108

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/005844 WO2001062378A2 (en) 2000-02-22 2001-02-22 Microarray fabrication techniques and apparatus

Country Status (8)

Country Link
US (1) US6953551B2 (en)
EP (1) EP1257355A2 (en)
JP (1) JP2004502923A (en)
KR (1) KR20030003686A (en)
CN (1) CN1416365A (en)
AU (1) AU6291301A (en)
CA (1) CA2399189A1 (en)
WO (1) WO2001062378A2 (en)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6893877B2 (en) 1998-01-12 2005-05-17 Massachusetts Institute Of Technology Methods for screening substances in a microwell array
US20020006359A1 (en) * 1998-11-25 2002-01-17 Affymetrix, Inc. Microplate sample and reagent loading system
US6887431B1 (en) * 1999-02-16 2005-05-03 Applera Corporation Bead dispensing system
US6306578B1 (en) 1999-03-19 2001-10-23 Genencor International, Inc. Multi-through hole testing plate for high throughput screening
GB2395484B (en) * 1999-04-30 2004-07-28 Agilent Technologies Inc Polynucleotide array fabrication
JP2003507715A (en) * 1999-08-13 2003-02-25 カーティージャン テクノロジーズ、 インコーポレイテッド Liquid sample handling equipment
US20020151040A1 (en) 2000-02-18 2002-10-17 Matthew O' Keefe Apparatus and methods for parallel processing of microvolume liquid reactions
US20040014102A1 (en) * 2000-02-22 2004-01-22 Shiping Chen High density parallel printing of microarrays
KR20020097181A (en) * 2000-02-22 2002-12-31 제노스펙트라 인코포레이티드 Microarray fabrication techniques and apparatus
WO2002078834A2 (en) * 2001-02-16 2002-10-10 Genospectra, Inc. Bundled capillaries apparatus for high throughput screening
JP4681749B2 (en) * 2001-03-28 2011-05-11 キヤノン株式会社 Probe carrier management method, probe carrier manufacturing apparatus, and probe carrier management apparatus
US7473767B2 (en) 2001-07-03 2009-01-06 The Institute For Systems Biology Methods for detection and quantification of analytes in complex mixtures
JP4252451B2 (en) * 2001-08-30 2009-04-08 浜松ホトニクス株式会社 Liquid droplet forming method and liquid droplet forming apparatus
JP2005528582A (en) * 2001-09-07 2005-09-22 コーニング インコーポレイテッド Array based on a microcolumn platform for high-throughput analysis
US20030148539A1 (en) * 2001-11-05 2003-08-07 California Institute Of Technology Micro fabricated fountain pen apparatus and method for ultra high density biological arrays
WO2003044527A1 (en) * 2001-11-22 2003-05-30 Riken Substrate for biomolecule microarray, process for producing the same, biomolecule microarray and method of collecting data on biomolecule microarray
AU2003218727A1 (en) * 2002-03-11 2003-09-22 Axaron Bioscience Ag Method for applying a substance to a substrate
JP2004028872A (en) * 2002-06-27 2004-01-29 Dna Chip Research Inc Solution for substrate spotting and spotting method
US8277753B2 (en) 2002-08-23 2012-10-02 Life Technologies Corporation Microfluidic transfer pin
TWI245739B (en) * 2002-12-05 2005-12-21 Ibm Method and device for flowing a liquid on a surface
EP1567264B1 (en) * 2002-12-05 2012-07-18 International Business Machines Corporation Confinement of liquids on surfaces
US20040109045A1 (en) * 2002-12-06 2004-06-10 Eastman Kodak Company Print head for micro-deposition of bio-molecules
CA2521999A1 (en) 2002-12-20 2004-09-02 Biotrove, Inc. Assay apparatus and method using microfluidic arrays
US20040120859A1 (en) * 2002-12-20 2004-06-24 Kocher Thomas E. Biomolecular micro-deposition system
US20040259182A1 (en) * 2003-06-17 2004-12-23 Brooks Edwards Arrays for chemiluminescent assays, methods of making the arrays and methods of detecting chemiluminescent emissions on solid supports
US20050181394A1 (en) * 2003-06-20 2005-08-18 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
US20040259100A1 (en) * 2003-06-20 2004-12-23 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
US7670810B2 (en) * 2003-06-20 2010-03-02 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
FR2857099B1 (en) * 2003-07-04 2005-10-07 Jean Marie Billiotte METHOD AND DEVICE FOR CHEMICAL OR BIOLOGICAL ANALYSIS BY MONOLITHIC CHAMBER SENSOR IN MULTI-MICRO-TUBULAR GERB AND LATERAL TRANSDUCER OF INTEGRAL MEASUREMENT
KR100647282B1 (en) * 2003-12-24 2006-11-17 삼성전자주식회사 Spoting device for manufacturing DNA microarray and spoting method using the same
DE102004062280A1 (en) * 2003-12-29 2005-07-28 Siemens Ag Laboratory spotting process and assembly to dispense fine droplets onto a substrate at intervals of less than 1 mm
KR100552705B1 (en) * 2004-01-07 2006-02-20 삼성전자주식회사 Device for printing biomolecule using electrohydrodynamic effect on substrate and printing method thereof
CA2559171A1 (en) 2004-03-12 2005-09-29 Biotrove, Inc. Nanoliter array loading
DE102005052713A1 (en) * 2005-11-04 2007-05-16 Clondiag Chip Tech Gmbh Apparatus and method for detecting molecular interactions
US20050247673A1 (en) * 2004-05-07 2005-11-10 International Business Machines Corporation Confinement of fluids on surfaces
EP1794321A2 (en) * 2004-07-30 2007-06-13 Whitehead Institute For Biomedical Research Markers of alterations in the y chromosome and uses therefor
US20060105453A1 (en) 2004-09-09 2006-05-18 Brenan Colin J Coating process for microfluidic sample arrays
CA2575350A1 (en) * 2004-08-04 2006-04-06 Biotrove, Inc. Method and system for registering dispenser array location
KR100624467B1 (en) * 2005-05-13 2006-09-15 삼성전자주식회사 Device for printing biomolecule using electrohydrodynamic effect on substrate
US7881577B1 (en) 2005-09-26 2011-02-01 Sherburne Slack Nanotube structures and methods for making and using nanotube structures
CA2640385C (en) 2005-12-23 2014-07-15 Nanostring Technologies, Inc. Nanoreporters and methods of manufacturing and use thereof
CA2646465C (en) 2006-03-17 2015-06-16 The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services Apparatus for microarray binding sensors having biological probe materials using carbon nanotube transistors
WO2007130434A2 (en) * 2006-05-02 2007-11-15 Applera Corporation Variable volume dispenser and method
TWI316873B (en) * 2006-08-08 2009-11-11 Ind Tech Res Inst Apparatus of manufacturing biochip and manufacture method of biochip tip array
KR100766619B1 (en) 2006-08-16 2007-10-12 재단법인서울대학교산학협력재단 Device for printing a mixed regent on wells of plate
JP5268383B2 (en) * 2008-02-07 2013-08-21 キヤノン株式会社 Molded body for forming a plurality of microdroplets and molding method thereof
CN102016596B (en) * 2008-03-27 2014-09-17 哈佛学院院长等 Paper-based microfluidic systems
US8899171B2 (en) 2008-06-13 2014-12-02 Kateeva, Inc. Gas enclosure assembly and system
US10434804B2 (en) 2008-06-13 2019-10-08 Kateeva, Inc. Low particle gas enclosure systems and methods
US9048344B2 (en) 2008-06-13 2015-06-02 Kateeva, Inc. Gas enclosure assembly and system
US8383202B2 (en) 2008-06-13 2013-02-26 Kateeva, Inc. Method and apparatus for load-locked printing
WO2010019826A1 (en) 2008-08-14 2010-02-18 Nanostring Technologies, Inc Stable nanoreporters
KR101611283B1 (en) * 2009-09-02 2016-04-26 엘지전자 주식회사 A refrigerator having a decorating member capable of displaying humidity and a production method for the decorating member for the refrigerator
WO2011047087A2 (en) 2009-10-13 2011-04-21 Nanostring Technologies, Inc. Protein detection via nanoreporters
JP5914362B2 (en) 2010-02-11 2016-05-11 ナノストリング テクノロジーズ， インコーポレイテッド Compositions and methods for the detection of small RNA molecules
JP5522493B2 (en) 2010-06-16 2014-06-18 ウシオ電機株式会社 Production apparatus, production method, antibody chip, program and recording medium
NZ707530A (en) * 2010-10-05 2017-04-28 Anpac Bio-Medical Science Co Ltd Micro-devices for disease detection
WO2012135340A2 (en) 2011-03-28 2012-10-04 Nanostring Technologies, Inc. Compositions and methods for diagnosing cancer
EP3087623B1 (en) 2013-12-26 2021-09-22 Kateeva, Inc. Thermal treatment of electronic devices
KR101813828B1 (en) 2014-01-21 2017-12-29 카티바, 인크. Apparatus and techniques for electronic device encapsulation
JP6461195B2 (en) 2014-04-30 2019-01-30 カティーバ， インコーポレイテッド Gas cushion apparatus and technique for substrate coating
US9480981B2 (en) 2014-07-25 2016-11-01 General Electric Company Sample collection and transfer device
US9901922B2 (en) 2014-07-25 2018-02-27 General Electric Company Sample collection and transfer device
EP3325650B1 (en) 2015-07-17 2024-01-03 Nanostring Technologies, Inc. Simultaneous quantification of gene expression in a user-defined region of a cross-sectioned tissue
US10501777B2 (en) 2015-07-17 2019-12-10 Nanostring Technologies, Inc. Simultaneous quantification of a plurality of proteins in a user-defined region of a cross-sectioned tissue
CN116334202A (en) 2016-11-21 2023-06-27 纳米线科技公司 Chemical compositions and methods of use thereof
SG11202007501SA (en) 2018-02-12 2020-09-29 Nanostring Technologies Inc Biomolecular probes and methods of detecting gene and protein expression
US11549139B2 (en) 2018-05-14 2023-01-10 Nanostring Technologies, Inc. Chemical compositions and methods of using same
WO2023200851A1 (en) * 2022-04-12 2023-10-19 Purdue Research Foundation Devices, systems, and methods for analyzing nanoparticles and microparticles

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0723995A (en) * 1993-07-07 1995-01-27 Yoshihiro Kishigami Cerebrospinal fluid distributor for promoting ossification of bioactive bone cement
US5630925A (en) * 1995-07-13 1997-05-20 Beckman Instruments, Inc. Capillary electrophoresis using a conductive capillary tube
US5690894A (en) * 1995-05-23 1997-11-25 The Regents Of The University Of California High density array fabrication and readout method for a fiber optic biosensor
WO1998029736A1 (en) * 1996-12-31 1998-07-09 Genometrix Incorporated Multiplexed molecular analysis apparatus and method
US5807522A (en) * 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
WO1998055593A1 (en) * 1997-06-06 1998-12-10 Orchid Biocomputer, Inc. Attachment of unmodified nucleic acids to silanized solid phase surfaces
WO1999013312A1 (en) * 1997-09-11 1999-03-18 Molecular Dynamics, Inc. Capillary valve, connector, and router
WO1999040434A1 (en) * 1998-02-04 1999-08-12 Invitrogen Corporation Microarrays and uses therefor
WO1999055461A1 (en) * 1998-04-27 1999-11-04 Corning Incorporated Redrawn capillary imaging reservoir
WO2000001798A2 (en) * 1998-07-07 2000-01-13 Cartesian Technologies, Inc. Tip design and random access array for microfluidic transfer
WO2000001859A2 (en) * 1998-07-02 2000-01-13 Orchid Biosciences, Inc. Gene pen devices for array printing

Family Cites Families (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4010019A (en) 1971-11-19 1977-03-01 American Optical Corporation Method of making microchannel plates
DE3410508C2 (en) * 1984-03-22 1986-06-26 Kernforschungsanlage Jülich GmbH, 5170 Jülich Serial filling device for filling the cups of a micro cup plate
US4981783A (en) 1986-04-16 1991-01-01 Montefiore Medical Center Method for detecting pathological conditions
US4877745A (en) 1986-11-17 1989-10-31 Abbott Laboratories Apparatus and process for reagent fluid dispensing and printing
US5525464A (en) 1987-04-01 1996-06-11 Hyseq, Inc. Method of sequencing by hybridization of oligonucleotide probes
US5700637A (en) 1988-05-03 1997-12-23 Isis Innovation Limited Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
US6054270A (en) 1988-05-03 2000-04-25 Oxford Gene Technology Limited Analying polynucleotide sequences
GB8822228D0 (en) 1988-09-21 1988-10-26 Southern E M Support-bound oligonucleotides
US4964539A (en) * 1989-04-06 1990-10-23 Seaquist Closures Multiple chamber dispensing container and closure system
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5102016A (en) * 1990-12-03 1992-04-07 Ball Lee R Apparatus for dispensing materials in touching association and methods of use thereof
US5474796A (en) 1991-09-04 1995-12-12 Protogene Laboratories, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface
US6305577B1 (en) * 1991-09-13 2001-10-23 Owens-Illinois Closure Inc. Squeeze dispenser package for viscous products
US5265327A (en) 1991-09-13 1993-11-30 Faris Sadeg M Microchannel plate technology
US5384261A (en) 1991-11-22 1995-01-24 Affymax Technologies N.V. Very large scale immobilized polymer synthesis using mechanically directed flow paths
US5276327A (en) 1991-12-09 1994-01-04 Measurex Corporation Sensor and method for mesaurement of select components of a material
US5565324A (en) 1992-10-01 1996-10-15 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
US5837832A (en) 1993-06-25 1998-11-17 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
GB9315847D0 (en) 1993-07-30 1993-09-15 Isis Innovation Tag reagent and assay method
US5986076A (en) 1994-05-11 1999-11-16 Trustees Of Boston University Photocleavable agents and conjugates for the detection and isolation of biomolecules
US5571639A (en) 1994-05-24 1996-11-05 Affymax Technologies N.V. Computer-aided engineering system for design of sequence arrays and lithographic masks
US5556752A (en) 1994-10-24 1996-09-17 Affymetrix, Inc. Surface-bound, unimolecular, double-stranded DNA
JPH08164954A (en) * 1994-12-15 1996-06-25 Yoshida Kogyo Kk <Ykk> Tube container
US5599695A (en) 1995-02-27 1997-02-04 Affymetrix, Inc. Printing molecular library arrays using deprotection agents solely in the vapor phase
US5624711A (en) 1995-04-27 1997-04-29 Affymax Technologies, N.V. Derivatization of solid supports and methods for oligomer synthesis
US5702033A (en) * 1995-06-07 1997-12-30 Continental Plastic Containers, Inc. Adjoined dual-tube dispenser
US5740297A (en) 1995-08-31 1998-04-14 Sumitomo Electric Industries, Ltd. Dispersion-compensating fiber and method of fabricating the same
US5658802A (en) 1995-09-07 1997-08-19 Microfab Technologies, Inc. Method and apparatus for making miniaturized diagnostic arrays
GB9521124D0 (en) * 1995-10-16 1995-12-20 Unilever Plc Dispenser
AU7612296A (en) 1995-11-14 1997-06-05 Baylor College Of Medicine Integrated nucleic acid hybridization devices based upon active surface chemistry
US5604587A (en) 1995-11-16 1997-02-18 World Precision Instruments, Inc. Long capillary waveguide raman cell
US5770151A (en) 1996-06-05 1998-06-23 Molecular Dynamics, Inc. High-speed liquid deposition device for biological molecule array formation
US5741554A (en) 1996-07-26 1998-04-21 Bio Dot, Inc. Method of dispensing a liquid reagent
US5900481A (en) 1996-11-06 1999-05-04 Sequenom, Inc. Bead linkers for immobilizing nucleic acids to solid supports
JP3204169B2 (en) 1997-07-23 2001-09-04 日本電気株式会社 Method for manufacturing semiconductor device
US6101946A (en) 1997-11-21 2000-08-15 Telechem International Inc. Microarray printing device including printing pins with flat tips and exterior channel and method of manufacture
DE69930726T2 (en) 1998-01-12 2007-01-25 Massachusetts Institute Of Technology, Cambridge METHOD AND DEVICE FOR MICROTEST PROCESSING
US6350618B1 (en) * 1998-04-27 2002-02-26 Corning Incorporated Redrawn capillary imaging reservoir
US6048695A (en) * 1998-05-04 2000-04-11 Baylor College Of Medicine Chemically modified nucleic acids and methods for coupling nucleic acids to solid support
US6245507B1 (en) 1998-08-18 2001-06-12 Orchid Biosciences, Inc. In-line complete hyperspectral fluorescent imaging of nucleic acid molecules
US6309891B1 (en) 1998-09-09 2001-10-30 Incyte Genomics, Inc. Capillary printing systems
AU3508600A (en) 1999-02-26 2000-09-14 Orchid Biosciences, Inc. Microstructures for use in biological assays and reactions
JP2000245461A (en) 1999-03-05 2000-09-12 Jenokkusu Soyaku Kenkyusho:Kk Nucleic acid-immobilized hollow fiber and arranged body of nucleic acid-immobilized hollow fiber and its thin layer
JP4108891B2 (en) 1999-03-31 2008-06-25 三菱レイヨン株式会社 Nucleic acid-immobilized gel-carrying porous hollow fiber, porous hollow fiber array and thin piece thereof
JP2000270877A (en) 1999-03-26 2000-10-03 Mitsubishi Rayon Co Ltd Nucleic acid-immobilized gel-holding porous fiber, arranged body of the porous fiber and section thereof
JP2000270878A (en) 1999-03-26 2000-10-03 Mitsubishi Rayon Co Ltd Nucleic acid-immobilized gel-holding hollow fiber, arranged body of the hollow fiber and section thereof
JP2000245460A (en) 1999-03-05 2000-09-12 Mitsubishi Rayon Co Ltd Nucleic acid-immobilized hollow fiber and arranged body of nucleic acid-immobilized hollow fibers and its thin specimen
JP2000279177A (en) 1999-03-31 2000-10-10 Mitsubishi Rayon Co Ltd Porous fiber in which nucleic acid was fixed, porous fiber array in which nucleic acid was fixed, and thin slice thereof
EP1595948A3 (en) 1999-03-05 2006-03-01 Mitsubishi Rayon Co., Ltd. Carriers having biological substance
JP2000270879A (en) 1999-03-26 2000-10-03 Mitsubishi Rayon Co Ltd Nucleic acid-immobilized gel-holding fiber, arranged body of the fiber and section thereof
US6027873A (en) 1999-03-19 2000-02-22 Genencor International, Inc. Multi-through hole testing plate for high throughput screening
US6368562B1 (en) 1999-04-16 2002-04-09 Orchid Biosciences, Inc. Liquid transportation system for microfluidic device
US6176395B1 (en) * 1999-04-21 2001-01-23 Pechiney Plastic Packaging, Inc. Dual dispense container
AU4988600A (en) 1999-05-04 2000-11-17 Orchid Biosciences, Inc. Multiple fluid sample processor with single well addressability
WO2000076662A2 (en) 1999-06-11 2000-12-21 Orchid Biosciences, Inc. Microenabled chemical reaction in microfluidic chips
WO2001006011A2 (en) 1999-07-14 2001-01-25 Genometrix Genomics, Inc. Arrays comprising non-covalently associated nucleic acid probes and methods for making and using them
JP3865107B2 (en) 2000-05-26 2007-01-10 横河電機株式会社 Biochip manufacturing method and biochip manufacturing apparatus using the same
WO2001030498A1 (en) 1999-10-26 2001-05-03 Genometrix Genomics Incorporated A storage card for hosting a biological specimen
WO2001031317A1 (en) 1999-10-26 2001-05-03 Genometrix Genomics Incorporated Method and apparatus for selectively retrieving biological samples for processing
AU1574801A (en) 1999-10-26 2001-05-08 Genometrix Genomics Incorporated Process for requesting biological experiments and for the delivery of experimental information
KR20020097181A (en) * 2000-02-22 2002-12-31 제노스펙트라 인코포레이티드 Microarray fabrication techniques and apparatus
US20020028160A1 (en) * 2000-02-22 2002-03-07 Jianming Xiao Method and apparatus based on bundled capillaries for high throughput screening
US6270340B1 (en) 2000-03-10 2001-08-07 Al Lepp Reusable candle wick
US20020072111A1 (en) 2000-12-13 2002-06-13 Clarkin James P. Drawn microchannel array devices and method of analysis using same
US20020164824A1 (en) * 2001-02-16 2002-11-07 Jianming Xiao Method and apparatus based on bundled capillaries for high throughput screening
EP1323474A1 (en) * 2001-12-31 2003-07-02 Corning Incorporated Device and process for simultaneous transfer of liquids

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0723995A (en) * 1993-07-07 1995-01-27 Yoshihiro Kishigami Cerebrospinal fluid distributor for promoting ossification of bioactive bone cement
US5807522A (en) * 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US5690894A (en) * 1995-05-23 1997-11-25 The Regents Of The University Of California High density array fabrication and readout method for a fiber optic biosensor
US5630925A (en) * 1995-07-13 1997-05-20 Beckman Instruments, Inc. Capillary electrophoresis using a conductive capillary tube
WO1998029736A1 (en) * 1996-12-31 1998-07-09 Genometrix Incorporated Multiplexed molecular analysis apparatus and method
WO1998055593A1 (en) * 1997-06-06 1998-12-10 Orchid Biocomputer, Inc. Attachment of unmodified nucleic acids to silanized solid phase surfaces
WO1999013312A1 (en) * 1997-09-11 1999-03-18 Molecular Dynamics, Inc. Capillary valve, connector, and router
WO1999040434A1 (en) * 1998-02-04 1999-08-12 Invitrogen Corporation Microarrays and uses therefor
WO1999055461A1 (en) * 1998-04-27 1999-11-04 Corning Incorporated Redrawn capillary imaging reservoir
WO2000001859A2 (en) * 1998-07-02 2000-01-13 Orchid Biosciences, Inc. Gene pen devices for array printing
WO2000001798A2 (en) * 1998-07-07 2000-01-13 Cartesian Technologies, Inc. Tip design and random access array for microfluidic transfer

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
BERTRAND LEMIEUX ET AL.: "OVERVIEW OF DNA CHIP TECHNOLOGY", MOLECULAR BREEDING: NEW STRATEGIES IN PLANT IMPROVEMENT, vol. 4, 1998, NL, pages 277 - 289, XP000915221, ISSN: 1380-3743 *
DEVAL A. LASHKARI ET AL.: "Yeast mmicroarrays for genome wide parallel genetic and gene expression analysis", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, vol. 94, November 1997 (1997-11-01), WASHINGTON, DC, USA, pages 13057 - 13062, XP002115013, ISSN: 0027-8424 *
MARK SCHENA ET AL.: "Microarrays: biotechnology's discovery platform for functional genomics", TIBTECH, vol. 16, no. 7, 1 July 1998 (1998-07-01), CAMBRIDGE, UK, pages 301 - 306, XP004145643, ISSN: 0167-7799 *
MARK SCHENA: "GENOME ANALYSIS WITH GENE EXPRESSION MICROARRAYS", BIOESSAYS, vol. 18, no. 5, 1996, CAMBRIDGE, UK, pages 427 - 431, XP002916033, ISSN: 0265-9247 *
MICHAEL B. EISEN ET AL.: "12 DNA ARRAYS FOR ANALYSIS OF GENE EXPRESSION", METHODS IN ENZYMOLOGY, vol. 303, 1999, SAN DIEGO, CA, USA, pages 179 - 205, XP000995864, ISSN: 0076-6879 *
PATENT ABSTRACTS OF JAPAN vol. 1995, no. 04 31 May 1995 (1995-05-31) *
YU-HUI ROGERS ET AL.: "IMMOBILIZATION OF OLIGONUCLEOTIDES ONTO A GLASS SUPPORT VIA DISULFIDE BONDS: A METHOD FOR PREPARATION OF DNA MICROARRAYS", ANALYTICAL BIOCHEMISTRY, vol. 266, no. 1, 1 January 1999 (1999-01-01), SAN DIEGO, CA, USA, pages 23 - 30, XP001005968, ISSN: 0003-2697 *

Also Published As

Publication number Publication date
WO2001062378A2 (en) 2001-08-30
AU6291301A (en) 2001-09-03
JP2004502923A (en) 2004-01-29
KR20030003686A (en) 2003-01-10
CA2399189A1 (en) 2001-08-30
EP1257355A2 (en) 2002-11-20
US20010053334A1 (en) 2001-12-20
US6953551B2 (en) 2005-10-11
CN1416365A (en) 2003-05-07

Similar Documents

Publication Publication Date Title
WO2001062378A3 (en) Microarray fabrication techniques and apparatus
WO2001062377A3 (en) Microarray fabrication techniques and apparatus
WO2003096015A1 (en) Biomolecular substrate, method of testing or diagnosis with use thereof and apparatus therefor
ITTO20010411A0 (en) METHOD AND DEVICE FOR PERFORMING HIGH PROCESSIVE AND HIGH BIOLOGICAL VALUE TEST AND ASSAY ON CELLS AND/OR COMPOUNDS.
DE69942066D1 (en) A SUBSTANCE ISOLATING DEVICE FOR THE USE OF AN INSPECTION INSTRUMENT
EP1398631A3 (en) Auto-calibration label for sensors, and apparatus comprising same
WO1999035505A3 (en) Method for removing accumulated solder from probe card probing features
CA2465800A1 (en) Instrument
EP1562045A3 (en) Bioarray chip reaction apparatus and its manufacture
EP1369700A3 (en) Distributed interface for parallel testing of multiple devices using a single tester channel
DE69935422D1 (en) SURFACE SIGNAL COMMAND PROBE OF ELECTRONIC DEVICE AND METHOD FOR THE PRODUCTION THEREOF
EP1273907A4 (en) Wafer inspecting method, wafer inspecting instrument, and electron beam apparatus
DE69917740D1 (en) DEVICE FOR TESTING A ROD-SAMPLE
BR0116564B1 (en) brake system diagnostic process, brake equipment diagnostic system and portable analyzer for testing and diagnosing a brake system.
NO994610L (en) Processing instrument for test devices
DE60238892D1 (en) Device for detecting a fine structure on the surface of a sample and method for producing a semiconductor device
ATE214805T1 (en) SYSTEM FOR DETERMINING AT LEAST ONE PARAMETER OF AT LEAST ONE SAMPLE OF A PHYSIOLOGICAL FLUID AND CASSETTE THEREOF
DE69934746D1 (en) Device for data recording, method for data recording
WO2005098462A3 (en) Probe card and method for constructing same
HK1024560A1 (en) Apparatus for coupling a test head and probe card in a wafer testing system.
AU2001230580A1 (en) Noninvasion biological optical measuring instrument, measured portion holding device, and method for manufacturing the same
DE69617058T2 (en) Clamping device for manufacturing an inkjet head
BR9917198B1 (en) test device for detecting or enumerating microorganisms, and process for using a test device.
CA2352515A1 (en) Methods for identifying combinations of entities as therapeutics
EP1091518A3 (en) Apparatus and method for measuring bit errors

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 62913/01

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 2399189

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 1020027010917

Country of ref document: KR

Ref document number: PA/A/2002/008150

Country of ref document: MX

ENP Entry into the national phase

Ref document number: 2001 561434

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 018054714

Country of ref document: CN

WWE Wipo information: entry into national phase

Ref document number: 2001937149

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2001937149

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1020027010917

Country of ref document: KR

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWW Wipo information: withdrawn in national office

Ref document number: 2001937149

Country of ref document: EP