WO2001064860A3 - Recombinant influenza a viruses - Google Patents
Recombinant influenza a viruses Download PDFInfo
- Publication number
- WO2001064860A3 WO2001064860A3 PCT/EP2001/002392 EP0102392W WO0164860A3 WO 2001064860 A3 WO2001064860 A3 WO 2001064860A3 EP 0102392 W EP0102392 W EP 0102392W WO 0164860 A3 WO0164860 A3 WO 0164860A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- gene
- virus
- relates
- influenza
- modification
- Prior art date
Links
- 241000856131 recombinant Influenza A viruses Species 0.000 title 1
- 238000012986 modification Methods 0.000 abstract 3
- 230000004048 modification Effects 0.000 abstract 3
- 241000713772 Human immunodeficiency virus 1 Species 0.000 abstract 2
- 101150076514 NS gene Proteins 0.000 abstract 2
- 101150033828 NS1 gene Proteins 0.000 abstract 2
- 241000700605 Viruses Species 0.000 abstract 2
- 238000003780 insertion Methods 0.000 abstract 2
- 230000037431 insertion Effects 0.000 abstract 2
- 241000712431 Influenza A virus Species 0.000 abstract 1
- 108700026244 Open Reading Frames Proteins 0.000 abstract 1
- 230000004570 RNA-binding Effects 0.000 abstract 1
- 101800001690 Transmembrane protein gp41 Proteins 0.000 abstract 1
- 238000012217 deletion Methods 0.000 abstract 1
- 230000037430 deletion Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 208000037797 influenza A Diseases 0.000 abstract 1
- 108700004028 nef Genes Proteins 0.000 abstract 1
- 101150023385 nef gene Proteins 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 238000013518 transcription Methods 0.000 abstract 1
- 230000035897 transcription Effects 0.000 abstract 1
- 241000712461 unidentified influenza virus Species 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Abstract
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU5035201A AU5035201A (en) | 2000-03-02 | 2001-03-02 | Recombinant influenza a viruses |
AT01923624T ATE299943T1 (en) | 2000-03-02 | 2001-03-02 | RECOMBINANT INFLUENZA A VIRUS |
US10/204,664 US6800288B2 (en) | 2000-03-02 | 2001-03-02 | Recombinant influenza A viruses |
EP01923624A EP1259629B1 (en) | 2000-03-02 | 2001-03-02 | Recombinant influenza a viruses |
AU2001250352A AU2001250352B2 (en) | 2000-03-02 | 2001-03-02 | Recombinant influenza a viruses |
DE60112050T DE60112050T2 (en) | 2000-03-02 | 2001-03-02 | RECOMBINANT INFLUENZA A VIRUS |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00104338.9 | 2000-03-02 | ||
EP00104338 | 2000-03-02 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2001064860A2 WO2001064860A2 (en) | 2001-09-07 |
WO2001064860A3 true WO2001064860A3 (en) | 2002-02-21 |
Family
ID=8168006
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2001/002392 WO2001064860A2 (en) | 2000-03-02 | 2001-03-02 | Recombinant influenza a viruses |
Country Status (7)
Country | Link |
---|---|
US (1) | US6800288B2 (en) |
EP (1) | EP1259629B1 (en) |
AT (1) | ATE299943T1 (en) |
AU (2) | AU2001250352B2 (en) |
DE (1) | DE60112050T2 (en) |
RU (1) | RU2280690C2 (en) |
WO (1) | WO2001064860A2 (en) |
Families Citing this family (52)
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---|---|---|---|---|
DK2316923T3 (en) | 1998-06-12 | 2018-01-08 | Icahn School Med Mount Sinai | Attenuated influenza viruses with altered interferon antagonist activity for use as vaccines and drugs |
US6635416B2 (en) | 2000-04-10 | 2003-10-21 | Mount Sinai School Of Medicine Of New York University | Screening methods for identifying viral proteins with interferon antagonizing functions and potential antiviral agents |
US7465456B2 (en) | 2002-04-26 | 2008-12-16 | Medimmune, Llc | Multi plasmid system for the production of influenza virus |
KR101229202B1 (en) | 2002-04-26 | 2013-02-01 | 메디뮨 엘엘씨 | Multi plasmid system for the production of influenza virus |
WO2004111249A2 (en) * | 2003-06-13 | 2004-12-23 | Polymun Scientific Immunbiologische Forschung Gmbh | Protein constructs containing caspase recognition sites |
EP2581093B1 (en) | 2003-06-16 | 2015-03-18 | MedImmune, LLC | Influenza hemagglutinin and neuraminidase variants |
US7037707B2 (en) * | 2003-09-04 | 2006-05-02 | St. Jude Children's Research Hospital | Method for generating influenza viruses and vaccines |
EP1697521B1 (en) | 2003-12-23 | 2010-06-02 | MedImmune, LLC | Multi plasmid system for the production of influenza virus |
ES2525672T3 (en) | 2004-05-25 | 2014-12-29 | Medimmune, Llc | Variants of hemagglutinin and influenza neuraminidase |
CA2610632C (en) | 2004-06-01 | 2022-10-04 | Mount Sinai School Of Medicine Of New York University | Genetically engineered swine influenza virus and uses thereof |
WO2006013367A2 (en) * | 2004-08-04 | 2006-02-09 | Medical Research Council | Chimeric heamaglutinin proteins and uses thereof |
WO2006088481A2 (en) * | 2005-02-15 | 2006-08-24 | Mount Sinai School Of Medicine Of New York University | Genetically engineered equine influenza virus and uses thereof |
EP1856271A4 (en) | 2005-03-08 | 2009-11-18 | Medimmune Vaccines Inc | Influenza hemagglutinin and neuraminidase variants |
AT502275B8 (en) * | 2005-08-08 | 2007-08-15 | Greenhills Biotechnology Res D | IMMUNE RESPONSE INDUCING COMPOSITIONS |
GEP20135924B (en) | 2005-12-02 | 2013-10-10 | The Mount Sinai School Of Medicine Of New York Univ | Chimeric viruses presenting non-native surface proteins and usage thereof |
EP2049662A4 (en) | 2006-07-21 | 2009-12-30 | Medimmune Llc | Methods and compositions for increasing replication capacity of an influenza virus |
JP2010500034A (en) | 2006-08-09 | 2010-01-07 | メッドイミューン バクシーンズ,インコーポレイティド | Influenza hemagglutinin mutant and neuraminidase mutant |
US20090098529A1 (en) | 2006-10-16 | 2009-04-16 | Nanhai Chen | Methods for attenuating virus strains for diagnostic and therapeutic uses |
WO2008150496A2 (en) * | 2007-05-31 | 2008-12-11 | Genelux Corporation | Assay for sensitivity to chemotherapeutic agents |
US20090117034A1 (en) * | 2007-06-15 | 2009-05-07 | Nanhai Chen | Microorganisms for imaging and/or treatment of tumors |
ES2523587T3 (en) | 2007-06-18 | 2014-11-27 | Medimmune, Llc | Influenza B viruses that have alterations in the hemagglutinin polypeptide |
EP2048237A1 (en) * | 2007-10-05 | 2009-04-15 | Avir Green Hills Biotechnology Research Development Trade Ag | Replication deficient Influenza virus for the expression of heterologous sequences |
TWI437036B (en) * | 2008-01-31 | 2014-05-11 | Sumitomo Chemical Co | Granular composition and production thereof |
CA2730408A1 (en) * | 2008-07-11 | 2010-01-14 | Chin-Fen Yang | Influenza hemagglutinin and neuraminidase variants |
BRPI1008549A2 (en) | 2009-02-12 | 2016-03-15 | Medimmune Llc | influenza neuraminidase and hemagglutinin variants |
US9217157B2 (en) | 2009-07-27 | 2015-12-22 | Icahn School Of Medicine At Mount Sinai | Recombinant influenza viruses and uses thereof |
CA2793959C (en) | 2010-03-25 | 2019-06-04 | Oregon Health & Science University | Cmv glycoproteins and recombinant vectors |
CN114262690A (en) | 2011-04-15 | 2022-04-01 | 吉恩勒克斯公司 | Clonal strains of attenuated vaccinia virus and methods of use thereof |
SI2691530T1 (en) | 2011-06-10 | 2018-08-31 | Oregon Health & Science University | Cmv glycoproteins and recombinant vectors |
US20130189754A1 (en) | 2011-09-12 | 2013-07-25 | International Aids Vaccine Initiative | Immunoselection of recombinant vesicular stomatitis virus expressing hiv-1 proteins by broadly neutralizing antibodies |
EP2586461A1 (en) | 2011-10-27 | 2013-05-01 | Christopher L. Parks | Viral particles derived from an enveloped virus |
KR101426407B1 (en) * | 2011-11-10 | 2014-08-07 | 서울대학교산학협력단 | Recombinant expression vector for preparing highly productive, highly immunogenic and avirulent influenza virus, and use thereof |
US20140087362A1 (en) | 2012-03-16 | 2014-03-27 | Aladar A. Szalay | Methods for assessing effectiveness and monitoring oncolytic virus treatment |
US20130280170A1 (en) | 2012-04-20 | 2013-10-24 | Aladar A. Szalay | Imaging methods for oncolytic virus therapy |
ES2631608T3 (en) | 2012-06-27 | 2017-09-01 | International Aids Vaccine Initiative | Env-glycoprotein variant of HIV-1 |
WO2014055960A1 (en) | 2012-10-05 | 2014-04-10 | Genelux Corporation | Energy absorbing-based diagnostic and therapeutic methods employing nucleic acid molecules encoding chromophore-producing enzymes |
EP2848937A1 (en) | 2013-09-05 | 2015-03-18 | International Aids Vaccine Initiative | Methods of identifying novel HIV-1 immunogens |
US10058604B2 (en) | 2013-10-07 | 2018-08-28 | International Aids Vaccine Initiative | Soluble HIV-1 envelope glycoprotein trimers |
CN111500631B (en) * | 2013-10-28 | 2024-03-29 | 蓝天免疫疗法有限责任公司 | Novel influenza virus vectors for viral therapy |
US10238700B2 (en) | 2014-01-02 | 2019-03-26 | Genelux Corporation | Oncolytic virus adjunct therapy with agents that increase virus infectivity |
MX2017010908A (en) | 2015-02-26 | 2017-12-07 | Boehringer Ingelheim Vetmedica Gmbh | Bivalent swine influenza virus vaccine. |
US10174292B2 (en) | 2015-03-20 | 2019-01-08 | International Aids Vaccine Initiative | Soluble HIV-1 envelope glycoprotein trimers |
EP3072901A1 (en) | 2015-03-23 | 2016-09-28 | International Aids Vaccine Initiative | Soluble hiv-1 envelope glycoprotein trimers |
RU2660562C2 (en) * | 2016-03-30 | 2018-07-06 | Общество с ограниченной ответственностью "ФАРМИНТЕРПРАЙСЕЗ БИОТЕХ" | Attenuated grippose vector and mucosal universal grippose vaccine on its basis |
EA037571B1 (en) * | 2015-11-06 | 2021-04-15 | Общество с ограниченной ответственностью "ФАРМИНТЕРПРАЙСЕЗ БИОТЕХ" | Attenuated influenza a virus, attenuated influenza vector, pharmaceutical composition and use thereof in the prevention or treatment of infectious diseases and for the treatment of oncological diseases |
RU2628690C2 (en) * | 2015-11-06 | 2017-08-21 | Общество С Ограниченной Ответственностью 'Фарминтерпрайсез' | Attenuated influenza vectors for the prevention and/or treatment of infectious diseases, as well as for cancer treatment |
RU2706544C1 (en) * | 2018-12-28 | 2019-11-19 | Общество с ограниченной ответственностью "Нанолек" | Concentrate of influenza vaccine and method for its preparation |
RU2701959C1 (en) * | 2018-12-28 | 2019-10-02 | Общество с ограниченной ответственностью "Нанолек" | Method of controlling production of a vaccine against influenza |
RU2706191C1 (en) * | 2018-12-28 | 2019-11-14 | Общество с ограниченной ответственностью "Нанолек" | Multivalent influenza vaccine |
RU2701953C1 (en) * | 2018-12-28 | 2019-10-02 | Общество с ограниченной ответственностью "Нанолек" | Method of producing a polyvalent influenza vaccine |
CN113481171B (en) * | 2021-06-21 | 2022-10-18 | 武汉大学 | Recombinant influenza virus strain carrying HIV-1 gene and preparation method and application thereof |
WO2024011250A1 (en) | 2022-07-08 | 2024-01-11 | Viromissile, Inc. | Oncolytic vaccinia viruses and recombinant viruses and methods of use thereof |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999064068A1 (en) * | 1998-06-12 | 1999-12-16 | Mount Sinai School Of Medicine Of The City University Of New York | Attenuated negative strand viruses with altered interferon antagonist activity for use as vaccines and pharmaceuticals |
WO1999064571A1 (en) * | 1998-06-12 | 1999-12-16 | Mount Sinai School Of Medicine Of The City University Of New York | Interferon inducing genetically engineered attenuated viruses |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5843724A (en) * | 1995-04-27 | 1998-12-01 | Rutgers University | Chimeric nucleic acids and proteins for inhibiting HIV-1 expression |
-
2001
- 2001-03-02 WO PCT/EP2001/002392 patent/WO2001064860A2/en active IP Right Grant
- 2001-03-02 EP EP01923624A patent/EP1259629B1/en not_active Expired - Lifetime
- 2001-03-02 AU AU2001250352A patent/AU2001250352B2/en not_active Ceased
- 2001-03-02 RU RU2002126205/13A patent/RU2280690C2/en not_active IP Right Cessation
- 2001-03-02 AT AT01923624T patent/ATE299943T1/en active
- 2001-03-02 US US10/204,664 patent/US6800288B2/en not_active Expired - Fee Related
- 2001-03-02 DE DE60112050T patent/DE60112050T2/en not_active Expired - Lifetime
- 2001-03-02 AU AU5035201A patent/AU5035201A/en active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999064068A1 (en) * | 1998-06-12 | 1999-12-16 | Mount Sinai School Of Medicine Of The City University Of New York | Attenuated negative strand viruses with altered interferon antagonist activity for use as vaccines and pharmaceuticals |
WO1999064571A1 (en) * | 1998-06-12 | 1999-12-16 | Mount Sinai School Of Medicine Of The City University Of New York | Interferon inducing genetically engineered attenuated viruses |
Non-Patent Citations (5)
Title |
---|
EGOROV ANDREJ ET AL: "Transfectant influenza A viruses with long deletions in the NS1 protein grow efficiently in vero cells.", JOURNAL OF VIROLOGY, vol. 72, no. 8, August 1998 (1998-08-01), pages 6437 - 6441, XP001034274, ISSN: 0022-538X * |
FERKO B ET AL: "Highly attenuated influenza A virus vectors expressing HIV-1 derived antigens induce mucosal and systemic immune responses in mice.", JOURNAL OF HUMAN VIROLOGY, vol. 3, no. 5, September 2000 (2000-09-01), 2000 International Meeting of the Institute of Human Virology;Baltimore, Maryland, USA; September 10-15, 2000, pages 253, XP001034381, ISSN: 1090-9508 * |
FERKO BORIS ET AL: "Chimeric influenza virus replicating predominantly in the murine upper respiratory tract induces local immune responses against human immunodeficiency virus type 1 in the genital tract.", JOURNAL OF INFECTIOUS DISEASES, vol. 178, no. 5, November 1998 (1998-11-01), pages 1359 - 1368, XP001035117, ISSN: 0022-1899 * |
GARCLA-SASTRE A ET AL: "INFLUENZA A VIRUS LACKING THE NS1 GENE REPLICATES IN INTERFERON-DEFICIENT SYSTEMS", VIROLOGY, ACADEMIC PRESS,ORLANDO, US, vol. 252, 20 December 1998 (1998-12-20), pages 324 - 330, XP000945121, ISSN: 0042-6822 * |
NORTON G P ET AL: "INFECTIOUS INFLUENZA A AND B VIRUS VARIANTS WITH LONG CARBOXYL TERMINAL DELETIONS IN THE NS1 POLYPEPTIDES", VIROLOGY, vol. 156, no. 2, 1987, pages 204 - 213, XP001039569, ISSN: 0042-6822 * |
Also Published As
Publication number | Publication date |
---|---|
DE60112050D1 (en) | 2005-08-25 |
AU5035201A (en) | 2001-09-12 |
AU2001250352B2 (en) | 2006-01-12 |
RU2280690C2 (en) | 2006-07-27 |
EP1259629B1 (en) | 2005-07-20 |
US6800288B2 (en) | 2004-10-05 |
EP1259629A2 (en) | 2002-11-27 |
DE60112050T2 (en) | 2006-04-27 |
ATE299943T1 (en) | 2005-08-15 |
RU2002126205A (en) | 2004-03-10 |
US20030147916A1 (en) | 2003-08-07 |
WO2001064860A2 (en) | 2001-09-07 |
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