WO2001068140A3 - Opioid formulations - Google Patents

Opioid formulations Download PDF

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Publication number
WO2001068140A3
WO2001068140A3 PCT/US2001/006955 US0106955W WO0168140A3 WO 2001068140 A3 WO2001068140 A3 WO 2001068140A3 US 0106955 W US0106955 W US 0106955W WO 0168140 A3 WO0168140 A3 WO 0168140A3
Authority
WO
WIPO (PCT)
Prior art keywords
formulations
fentanyl
concentration
subject
further provides
Prior art date
Application number
PCT/US2001/006955
Other languages
French (fr)
Other versions
WO2001068140A2 (en
Inventor
Dana Litmanovitz
Barbara J F Laidlaw
Original Assignee
Durect Corp
Dana Litmanovitz
Barbara J F Laidlaw
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Durect Corp, Dana Litmanovitz, Barbara J F Laidlaw filed Critical Durect Corp
Priority to AU2001243414A priority Critical patent/AU2001243414B2/en
Priority to AU4341401A priority patent/AU4341401A/en
Priority to JP2001566703A priority patent/JP4969009B2/en
Priority to US10/220,525 priority patent/US7074803B2/en
Priority to CA002402865A priority patent/CA2402865A1/en
Publication of WO2001068140A2 publication Critical patent/WO2001068140A2/en
Publication of WO2001068140A3 publication Critical patent/WO2001068140A3/en
Priority to US10/188,325 priority patent/US6835194B2/en
Priority to US10/922,239 priority patent/US20050106205A1/en
Priority to US13/355,217 priority patent/US20120239007A1/en
Priority to US14/260,181 priority patent/US20140350053A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Abstract

The present invention provides high-concentration formulations of opioids such as fentanyl or fentanyl congeners. The formulation of the invention comprises fentanyl or a fentanyl congener in concentrations significantly in excess of conventional formulations, e.g., on the order about 2-fold to about 10,000-fold greater than conventional formulations, e.g., currently commercially available formulations. These formulations are particularly useful for long-term delivery to a subject suffering from pain. The invention further provides drug delivery devices comprising the high-concentration opioid formulations, and further provides methods of alleviating pain in a subject, comprising administering the high-concentration formulations to a subject in need thereof.
PCT/US2001/006955 1999-03-18 2001-03-02 Opioid formulations WO2001068140A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
AU2001243414A AU2001243414B2 (en) 2000-03-10 2001-03-02 Opioid formulations
AU4341401A AU4341401A (en) 2000-03-10 2001-03-02 Opioid formulations
JP2001566703A JP4969009B2 (en) 2000-03-10 2001-03-02 Opioid formulation
US10/220,525 US7074803B2 (en) 2001-03-02 2001-03-02 Opioid formulations
CA002402865A CA2402865A1 (en) 2000-03-10 2001-03-02 Opioid formulations
US10/188,325 US6835194B2 (en) 1999-03-18 2002-06-27 Implantable devices and methods for treatment of pain by delivery of fentanyl and fentanyl congeners
US10/922,239 US20050106205A1 (en) 1999-03-18 2004-08-18 Implantable devices and methods for treatment of pain by delivery of fentanyl and fentanyl congeners
US13/355,217 US20120239007A1 (en) 1999-03-18 2012-01-20 Implantable Devices and Methods for Treatment of Pain by Delivery of Fentanyl and Fentanyl Congeners
US14/260,181 US20140350053A1 (en) 2000-03-10 2014-04-23 Opioid formulations

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18826300P 2000-03-10 2000-03-10
US60/188,263 2000-03-10

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US09/522,535 Continuation-In-Part US6541021B1 (en) 1999-03-18 2000-03-10 Devices and methods for pain management

Related Child Applications (4)

Application Number Title Priority Date Filing Date
US10/220,525 A-371-Of-International US7074803B2 (en) 2000-03-10 2001-03-02 Opioid formulations
PCT/US2001/043143 Continuation-In-Part WO2002043800A2 (en) 1999-03-18 2001-11-21 Devices and methods for controlled delivery from a drug delivery device
US10/188,325 Continuation-In-Part US6835194B2 (en) 1999-03-18 2002-06-27 Implantable devices and methods for treatment of pain by delivery of fentanyl and fentanyl congeners
US11/477,140 Continuation US20070014820A1 (en) 2000-03-10 2006-06-27 Opioid formulations

Publications (2)

Publication Number Publication Date
WO2001068140A2 WO2001068140A2 (en) 2001-09-20
WO2001068140A3 true WO2001068140A3 (en) 2001-12-13

Family

ID=22692427

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/006955 WO2001068140A2 (en) 1999-03-18 2001-03-02 Opioid formulations

Country Status (4)

Country Link
JP (1) JP4969009B2 (en)
AU (2) AU2001243414B2 (en)
CA (1) CA2402865A1 (en)
WO (1) WO2001068140A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0300531D0 (en) 2003-01-10 2003-02-12 West Pharm Serv Drug Res Ltd Pharmaceutical compositions
US8940311B2 (en) * 2004-10-21 2015-01-27 Tae-Hong Lim In situ controlled release drug delivery system
US20140179740A1 (en) * 2012-12-21 2014-06-26 Mylan Inc. Stable liquid remifentanil formulations
JP6081240B2 (en) * 2013-03-13 2017-02-15 テルモ株式会社 Remifentanil injection
WO2016038734A1 (en) 2014-09-12 2016-03-17 テルモ株式会社 Remifentanil injection

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4588580A (en) * 1984-07-23 1986-05-13 Alza Corporation Transdermal administration of fentanyl and device therefor
WO1990007333A1 (en) * 1989-01-06 1990-07-12 Riker Laboratories, Inc. Fentanyl containing aerosol compositions
WO1997049402A1 (en) * 1996-06-27 1997-12-31 Janssen Pharmaceutica N.V. Sustained release sufentanil compositions
US5910301A (en) * 1994-05-13 1999-06-08 Aradigm Corporation Method of intrapulmonary administration of a narcotic drug
WO2000054745A2 (en) * 1999-03-18 2000-09-21 Durect Corporation Devices and methods for pain management

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA856002B (en) * 1984-08-10 1987-04-29 Du Pont Transdermal delivery of opioids
JPH05331064A (en) * 1992-05-26 1993-12-14 Sekisui Chem Co Ltd Anti-inflammatory analgesic plaster
JPH07206903A (en) * 1994-01-24 1995-08-08 Takeda Chem Ind Ltd Aggregate of super molecule structure type
JPH09176000A (en) * 1995-12-28 1997-07-08 Teijin Ltd Plaster for medical use

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4588580A (en) * 1984-07-23 1986-05-13 Alza Corporation Transdermal administration of fentanyl and device therefor
US4588580B1 (en) * 1984-07-23 1989-01-03
US4588580B2 (en) * 1984-07-23 1999-02-16 Alaz Corp Transdermal administration of fentanyl and device therefor
WO1990007333A1 (en) * 1989-01-06 1990-07-12 Riker Laboratories, Inc. Fentanyl containing aerosol compositions
US5910301A (en) * 1994-05-13 1999-06-08 Aradigm Corporation Method of intrapulmonary administration of a narcotic drug
WO1997049402A1 (en) * 1996-06-27 1997-12-31 Janssen Pharmaceutica N.V. Sustained release sufentanil compositions
WO2000054745A2 (en) * 1999-03-18 2000-09-21 Durect Corporation Devices and methods for pain management

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1995, RAMSAY E C ET AL: "Immobilization of black bears (Ursus americanus) with orally administered carfentanil citrate.", XP002175618, Database accession no. PREV199598404995 *
JOURNAL OF WILDLIFE DISEASES, vol. 31, no. 3, 1995, pages 391 - 393, ISSN: 0090-3558 *

Also Published As

Publication number Publication date
AU2001243414B2 (en) 2005-05-19
AU4341401A (en) 2001-09-24
JP2003526680A (en) 2003-09-09
JP4969009B2 (en) 2012-07-04
CA2402865A1 (en) 2001-09-20
WO2001068140A2 (en) 2001-09-20

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