WO2001069222A3 - Implantable analyte sensor - Google Patents

Implantable analyte sensor Download PDF

Info

Publication number
WO2001069222A3
WO2001069222A3 PCT/EP2001/003026 EP0103026W WO0169222A3 WO 2001069222 A3 WO2001069222 A3 WO 2001069222A3 EP 0103026 W EP0103026 W EP 0103026W WO 0169222 A3 WO0169222 A3 WO 0169222A3
Authority
WO
WIPO (PCT)
Prior art keywords
analyte sensor
implantable analyte
electrodes
membrane
substrate
Prior art date
Application number
PCT/EP2001/003026
Other languages
French (fr)
Other versions
WO2001069222A2 (en
Inventor
Matthias Essenpreis
Original Assignee
Roche Diagnostics Gmbh
Matthias Essenpreis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Diagnostics Gmbh, Matthias Essenpreis filed Critical Roche Diagnostics Gmbh
Priority to EP01933715A priority Critical patent/EP1304952A2/en
Priority to CA002406814A priority patent/CA2406814A1/en
Priority to JP2001568055A priority patent/JP2003527599A/en
Priority to AU2001260130A priority patent/AU2001260130A1/en
Publication of WO2001069222A2 publication Critical patent/WO2001069222A2/en
Publication of WO2001069222A3 publication Critical patent/WO2001069222A3/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1486Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase
    • A61B5/14865Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001Enzyme electrodes
    • C12Q1/005Enzyme electrodes involving specific analytes or enzymes
    • C12Q1/006Enzyme electrodes involving specific analytes or enzymes for glucose

Abstract

An implantable analyte sensor includes a substrate, electrodes on the substrate, and a membrane on the electrodes. The membrane can comprise elemental silicon. The sensor can exhibit a signal drift of less than 20 % per day in vivo.
PCT/EP2001/003026 2000-03-17 2001-03-16 Implantable analyte sensor WO2001069222A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP01933715A EP1304952A2 (en) 2000-03-17 2001-03-16 Implantable analyte sensor
CA002406814A CA2406814A1 (en) 2000-03-17 2001-03-16 Implantable analyte sensor
JP2001568055A JP2003527599A (en) 2000-03-17 2001-03-16 Embedded analyte sensor
AU2001260130A AU2001260130A1 (en) 2000-03-17 2001-03-16 Implantable analyte sensor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52830600A 2000-03-17 2000-03-17
US09/528,306 2000-03-17

Publications (2)

Publication Number Publication Date
WO2001069222A2 WO2001069222A2 (en) 2001-09-20
WO2001069222A3 true WO2001069222A3 (en) 2002-01-03

Family

ID=24105119

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/003026 WO2001069222A2 (en) 2000-03-17 2001-03-16 Implantable analyte sensor

Country Status (5)

Country Link
EP (1) EP1304952A2 (en)
JP (1) JP2003527599A (en)
AU (1) AU2001260130A1 (en)
CA (1) CA2406814A1 (en)
WO (1) WO2001069222A2 (en)

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8840553B2 (en) 1998-04-30 2014-09-23 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8843187B2 (en) 2003-08-22 2014-09-23 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
US8886273B2 (en) 2003-08-01 2014-11-11 Dexcom, Inc. Analyte sensor
US8882741B2 (en) 2004-02-26 2014-11-11 Dexcom, Inc. Integrated delivery device for continuous glucose sensor
US8915850B2 (en) 2005-11-01 2014-12-23 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8915849B2 (en) 2003-08-01 2014-12-23 Dexcom, Inc. Transcutaneous analyte sensor
US8920319B2 (en) 2005-11-01 2014-12-30 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8974386B2 (en) 1998-04-30 2015-03-10 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8986209B2 (en) 2003-08-01 2015-03-24 Dexcom, Inc. Transcutaneous analyte sensor
US9011332B2 (en) 2001-01-02 2015-04-21 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US9107623B2 (en) 2003-12-09 2015-08-18 Dexcom, Inc. Signal processing for continuous analyte sensor
US9220449B2 (en) 2005-03-10 2015-12-29 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
US9282925B2 (en) 2002-02-12 2016-03-15 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
US9328371B2 (en) 2001-07-27 2016-05-03 Dexcom, Inc. Sensor head for use with implantable devices
US9357951B2 (en) 2009-09-30 2016-06-07 Dexcom, Inc. Transcutaneous analyte sensor
US9414777B2 (en) 2004-07-13 2016-08-16 Dexcom, Inc. Transcutaneous analyte sensor
US9420968B2 (en) 2003-08-22 2016-08-23 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
US9446194B2 (en) 2009-03-27 2016-09-20 Dexcom, Inc. Methods and systems for promoting glucose management
US9451908B2 (en) 2006-10-04 2016-09-27 Dexcom, Inc. Analyte sensor
US9538946B2 (en) 2003-11-19 2017-01-10 Dexcom, Inc. Integrated receiver for continuous analyte sensor
US9549693B2 (en) 2002-05-22 2017-01-24 Dexcom, Inc. Silicone based membranes for use in implantable glucose sensors

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8527026B2 (en) 1997-03-04 2013-09-03 Dexcom, Inc. Device and method for determining analyte levels
US6862465B2 (en) 1997-03-04 2005-03-01 Dexcom, Inc. Device and method for determining analyte levels
US8480580B2 (en) 1998-04-30 2013-07-09 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8465425B2 (en) 1998-04-30 2013-06-18 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US9066695B2 (en) 1998-04-30 2015-06-30 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US6702857B2 (en) 2001-07-27 2004-03-09 Dexcom, Inc. Membrane for use with implantable devices
US8364229B2 (en) 2003-07-25 2013-01-29 Dexcom, Inc. Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
US8260393B2 (en) 2003-07-25 2012-09-04 Dexcom, Inc. Systems and methods for replacing signal data artifacts in a glucose sensor data stream
EP1578262A4 (en) 2002-12-31 2007-12-05 Therasense Inc Continuous glucose monitoring system and methods of use
CA2473069C (en) 2003-07-11 2014-03-18 F. Hoffmann-La Roche Ag Castable diffusion membrane for enzyme-based sensor application
EP1502957B1 (en) * 2003-07-11 2008-08-27 F. Hoffmann-La Roche Ag Castable diffusion membrane for enzyme-based sensor application
US9763609B2 (en) 2003-07-25 2017-09-19 Dexcom, Inc. Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
US8761856B2 (en) 2003-08-01 2014-06-24 Dexcom, Inc. System and methods for processing analyte sensor data
US8060173B2 (en) 2003-08-01 2011-11-15 Dexcom, Inc. System and methods for processing analyte sensor data
US20190357827A1 (en) 2003-08-01 2019-11-28 Dexcom, Inc. Analyte sensor
US20140121989A1 (en) 2003-08-22 2014-05-01 Dexcom, Inc. Systems and methods for processing analyte sensor data
EP1681992B2 (en) 2003-09-30 2015-03-04 Roche Diagnostics GmbH Sensor with increased biocompatibility
US9247900B2 (en) 2004-07-13 2016-02-02 Dexcom, Inc. Analyte sensor
US8774886B2 (en) 2006-10-04 2014-07-08 Dexcom, Inc. Analyte sensor
US11633133B2 (en) 2003-12-05 2023-04-25 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US8423114B2 (en) 2006-10-04 2013-04-16 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US8808228B2 (en) 2004-02-26 2014-08-19 Dexcom, Inc. Integrated medicament delivery device for use with continuous analyte sensor
US20060270922A1 (en) 2004-07-13 2006-11-30 Brauker James H Analyte sensor
WO2006090873A1 (en) * 2005-02-25 2006-08-31 Ultizyme International Ltd. Fuel cell-type enzyme sensor
US8744546B2 (en) 2005-05-05 2014-06-03 Dexcom, Inc. Cellulosic-based resistance domain for an analyte sensor
US20200037875A1 (en) 2007-05-18 2020-02-06 Dexcom, Inc. Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
EP2152350A4 (en) 2007-06-08 2013-03-27 Dexcom Inc Integrated medicament delivery device for use with continuous analyte sensor
EP2227132B1 (en) 2007-10-09 2023-03-08 DexCom, Inc. Integrated insulin delivery system with continuous glucose sensor
JP5212982B2 (en) * 2008-11-06 2013-06-19 独立行政法人物質・材料研究機構 Electrodes for electrochemical measuring devices and electrodes for biosensors
WO2012142502A2 (en) 2011-04-15 2012-10-18 Dexcom Inc. Advanced analyte sensor calibration and error detection
US11331022B2 (en) 2017-10-24 2022-05-17 Dexcom, Inc. Pre-connected analyte sensors
CA3077720A1 (en) 2017-10-24 2019-05-02 Dexcom, Inc. Pre-connected analyte sensors
US11638543B2 (en) 2019-07-16 2023-05-02 Dexcom, Inc. Analyte sensor electrode arrangements

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0284518A2 (en) * 1987-03-27 1988-09-28 Isao Karube Miniaturized oxygen electrode and miniaturized biosensor and production process thereof
US5773270A (en) * 1991-03-12 1998-06-30 Chiron Diagnostics Corporation Three-layered membrane for use in an electrochemical sensor system
WO1998038906A1 (en) * 1997-03-04 1998-09-11 Markwell Medical Institute, Inc. Device and method for determining analyte levels
US5874047A (en) * 1994-08-06 1999-02-23 Forschungszentrum Julich Gmbh Chemical sensors, in particular silicon-based biosensors

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4650547A (en) 1983-05-19 1987-03-17 The Regents Of The University Of California Method and membrane applicable to implantable sensor
US5431160A (en) 1989-07-19 1995-07-11 University Of New Mexico Miniature implantable refillable glucose sensor and material therefor
US5165407A (en) 1990-04-19 1992-11-24 The University Of Kansas Implantable glucose sensor
US5593852A (en) 1993-12-02 1997-01-14 Heller; Adam Subcutaneous glucose electrode
US5387327A (en) 1992-10-19 1995-02-07 Duquesne University Of The Holy Ghost Implantable non-enzymatic electrochemical glucose sensor
ZA938555B (en) 1992-11-23 1994-08-02 Lilly Co Eli Technique to improve the performance of electrochemical sensors
GB9304306D0 (en) 1993-03-03 1993-04-21 Univ Alberta Glucose sensor
US5786439A (en) 1996-10-24 1998-07-28 Minimed Inc. Hydrophilic, swellable coatings for biosensors
US5711861A (en) 1995-11-22 1998-01-27 Ward; W. Kenneth Device for monitoring changes in analyte concentration
WO1998013685A1 (en) 1996-09-26 1998-04-02 Minimed, Inc. Silicon-containing biocompatible membranes
US5997817A (en) 1997-12-05 1999-12-07 Roche Diagnostics Corporation Electrochemical biosensor test strip

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0284518A2 (en) * 1987-03-27 1988-09-28 Isao Karube Miniaturized oxygen electrode and miniaturized biosensor and production process thereof
US5773270A (en) * 1991-03-12 1998-06-30 Chiron Diagnostics Corporation Three-layered membrane for use in an electrochemical sensor system
US5874047A (en) * 1994-08-06 1999-02-23 Forschungszentrum Julich Gmbh Chemical sensors, in particular silicon-based biosensors
WO1998038906A1 (en) * 1997-03-04 1998-09-11 Markwell Medical Institute, Inc. Device and method for determining analyte levels

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HANSFORD DEREK JAMES: "Microfabrication Materials for Biomedical Microdevices", DISSERTATION SUBMITTED TO THE UNIVERSITY OF CALIFORNIA, BERKELEY, SPRING 1999, pages 10-14,54,56-58,63,68,94,95,107,108, XP002176863 *
SCHNAKENBERG U ET AL: "Novel potentiometric silicon sensor for medical devices", SENSORS AND ACTUATORS B, ELSEVIER SEQUOIA S.A., LAUSANNE, CH, vol. 34, no. 1-3, 1 August 1996 (1996-08-01), pages 476 - 480, XP004078027, ISSN: 0925-4005 *

Cited By (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9011331B2 (en) 1998-04-30 2015-04-21 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8880137B2 (en) 1998-04-30 2014-11-04 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US9072477B2 (en) 1998-04-30 2015-07-07 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8840553B2 (en) 1998-04-30 2014-09-23 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US9326714B2 (en) 1998-04-30 2016-05-03 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8974386B2 (en) 1998-04-30 2015-03-10 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US9014773B2 (en) 1998-04-30 2015-04-21 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US9498159B2 (en) 2001-01-02 2016-11-22 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US9011332B2 (en) 2001-01-02 2015-04-21 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US9328371B2 (en) 2001-07-27 2016-05-03 Dexcom, Inc. Sensor head for use with implantable devices
US9282925B2 (en) 2002-02-12 2016-03-15 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
US9549693B2 (en) 2002-05-22 2017-01-24 Dexcom, Inc. Silicone based membranes for use in implantable glucose sensors
US8886273B2 (en) 2003-08-01 2014-11-11 Dexcom, Inc. Analyte sensor
US8986209B2 (en) 2003-08-01 2015-03-24 Dexcom, Inc. Transcutaneous analyte sensor
US8915849B2 (en) 2003-08-01 2014-12-23 Dexcom, Inc. Transcutaneous analyte sensor
US9420968B2 (en) 2003-08-22 2016-08-23 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
US8843187B2 (en) 2003-08-22 2014-09-23 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
US9149219B2 (en) 2003-08-22 2015-10-06 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
US9427183B2 (en) 2003-08-22 2016-08-30 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
US9510782B2 (en) 2003-08-22 2016-12-06 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
US9585607B2 (en) 2003-08-22 2017-03-07 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
US9538946B2 (en) 2003-11-19 2017-01-10 Dexcom, Inc. Integrated receiver for continuous analyte sensor
US9107623B2 (en) 2003-12-09 2015-08-18 Dexcom, Inc. Signal processing for continuous analyte sensor
US9351668B2 (en) 2003-12-09 2016-05-31 Dexcom, Inc. Signal processing for continuous analyte sensor
US9192328B2 (en) 2003-12-09 2015-11-24 Dexcom, Inc. Signal processing for continuous analyte sensor
US9364173B2 (en) 2003-12-09 2016-06-14 Dexcom, Inc. Signal processing for continuous analyte sensor
US9498155B2 (en) 2003-12-09 2016-11-22 Dexcom, Inc. Signal processing for continuous analyte sensor
US9420965B2 (en) 2003-12-09 2016-08-23 Dexcom, Inc. Signal processing for continuous analyte sensor
US8926585B2 (en) 2004-02-26 2015-01-06 Dexcom, Inc. Integrated delivery device for continuous glucose sensor
US8882741B2 (en) 2004-02-26 2014-11-11 Dexcom, Inc. Integrated delivery device for continuous glucose sensor
US8920401B2 (en) 2004-02-26 2014-12-30 Dexcom, Inc. Integrated delivery device for continuous glucose sensor
US9155843B2 (en) 2004-02-26 2015-10-13 Dexcom, Inc. Integrated delivery device for continuous glucose sensor
US9414777B2 (en) 2004-07-13 2016-08-16 Dexcom, Inc. Transcutaneous analyte sensor
US9314196B2 (en) 2005-03-10 2016-04-19 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
US9220449B2 (en) 2005-03-10 2015-12-29 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
US8915850B2 (en) 2005-11-01 2014-12-23 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US9326716B2 (en) 2005-11-01 2016-05-03 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8920319B2 (en) 2005-11-01 2014-12-30 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US9451908B2 (en) 2006-10-04 2016-09-27 Dexcom, Inc. Analyte sensor
US9446194B2 (en) 2009-03-27 2016-09-20 Dexcom, Inc. Methods and systems for promoting glucose management
US9357951B2 (en) 2009-09-30 2016-06-07 Dexcom, Inc. Transcutaneous analyte sensor

Also Published As

Publication number Publication date
JP2003527599A (en) 2003-09-16
WO2001069222A2 (en) 2001-09-20
AU2001260130A1 (en) 2001-09-24
EP1304952A2 (en) 2003-05-02
CA2406814A1 (en) 2001-09-20

Similar Documents

Publication Publication Date Title
WO2001069222A3 (en) Implantable analyte sensor
WO2001068901A3 (en) Implantable analyte sensor
AU6099100A (en) Ultra-rugged i.c. sensor and method of making the same
AU2465999A (en) Electrochemical analyte sensor
EP1439796B8 (en) Areal implant
AU4027000A (en) Filter element with membrane and bicomponent substrate
AU4372199A (en) Electrochemical based assay processes, instrument and labels
EP1153291A4 (en) Micro-machined thin film hydrogen gas sensor, and method of making and using the same
AU3664899A (en) Substrate sensor
AU2001259656A1 (en) Implantable sensor
AU4084199A (en) Piezoelectric quartz crystal hydrogen sensor, and hydrogen sensing method utilizing same
AU2002221771A1 (en) Cation-conducting or proton-conducting ceramic membrane based on a hydroxysilylic acid, method for the production thereof and use of the same
AU6142999A (en) Battery polarity insensitive integrated circuit amplifier
HK1030834A1 (en) Electrode means, with or without functional elements and an electrode device formed of said means.
AU5130299A (en) Wrist-mounted i.v. administration set
CA2318161A1 (en) Microfabricated aperture-based sensor
AU5585899A (en) Cannula tip pressure sensor
WO2004034493A3 (en) Fuel cell assembly and method of making the same
EP1096243A3 (en) Physical sensor, in particular semiconductive pressure sensor
AU6397300A (en) Ph sensor for indicating the ph of a sample, the fabrication and use thereof
AU1285000A (en) Electrochemical sensor
AU2001280358A1 (en) Electrochromic device based on nanocrystalline materials
AU1042401A (en) Electrochemical gas sensor
AU2002343717A1 (en) Ph glass membrane and sensor
AU2998500A (en) Wafer sensor utilizing hydrodynamic pressure differential

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 2001933715

Country of ref document: EP

ENP Entry into the national phase

Ref country code: JP

Ref document number: 2001 568055

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: 2406814

Country of ref document: CA

WWP Wipo information: published in national office

Ref document number: 2001933715

Country of ref document: EP