WO2001070289A3 - Injectable and swellable microspheres for tissue bulking - Google Patents

Injectable and swellable microspheres for tissue bulking Download PDF

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Publication number
WO2001070289A3
WO2001070289A3 PCT/US2001/008405 US0108405W WO0170289A3 WO 2001070289 A3 WO2001070289 A3 WO 2001070289A3 US 0108405 W US0108405 W US 0108405W WO 0170289 A3 WO0170289 A3 WO 0170289A3
Authority
WO
WIPO (PCT)
Prior art keywords
tissue bulking
injectable
swellable
swellable microspheres
relates
Prior art date
Application number
PCT/US2001/008405
Other languages
French (fr)
Other versions
WO2001070289A2 (en
Inventor
Jean-Marie Vogel
Egisto Boschetti
Original Assignee
Biosphere Medical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biosphere Medical Inc filed Critical Biosphere Medical Inc
Priority to EP01922415A priority Critical patent/EP1274472A2/en
Priority to AU2001249221A priority patent/AU2001249221A1/en
Publication of WO2001070289A2 publication Critical patent/WO2001070289A2/en
Publication of WO2001070289A3 publication Critical patent/WO2001070289A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A61K31/78—Polymers containing oxygen of acrylic acid or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/005—Ingredients of undetermined constitution or reaction products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions

Abstract

The present invention relates to injectable compositions comprising biocompatible, swellable, hydrophilic, non-toxic and substantially spherical microspheres useful for tissue bulking. The invention also relates to methods of tissue bulking, particularly for the treatment of Gastro-esophageal reflux disease, urinary incontinence, or urinary reflux disease, using the injectable compositions.
PCT/US2001/008405 2000-03-20 2001-03-15 Injectable and swellable microspheres for tissue bulking WO2001070289A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP01922415A EP1274472A2 (en) 2000-03-20 2001-03-15 Injectable and swellable microspheres for tissue bulking
AU2001249221A AU2001249221A1 (en) 2000-03-20 2001-03-15 Injectable and swellable microspheres for tissue bulking

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52898900A 2000-03-20 2000-03-20
US09/528,989 2000-03-20

Publications (2)

Publication Number Publication Date
WO2001070289A2 WO2001070289A2 (en) 2001-09-27
WO2001070289A3 true WO2001070289A3 (en) 2002-06-27

Family

ID=24108039

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/008405 WO2001070289A2 (en) 2000-03-20 2001-03-15 Injectable and swellable microspheres for tissue bulking

Country Status (4)

Country Link
US (2) US9017710B2 (en)
EP (1) EP1274472A2 (en)
AU (1) AU2001249221A1 (en)
WO (1) WO2001070289A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
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US9023380B2 (en) 2005-11-22 2015-05-05 Aderans Research Institute, Inc. Hair follicle graft from tissue engineered skin
US9040022B2 (en) 2005-05-09 2015-05-26 Biosphere Medical, S.A. Compositions and methods using microspheres and non-ionic contrast agents

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6660301B1 (en) 1998-03-06 2003-12-09 Biosphere Medical, Inc. Injectable microspheres for dermal augmentation and tissue bulking
FR2784580B1 (en) 1998-10-16 2004-06-25 Biosepra Inc POLYVINYL-ALCOHOL MICROSPHERES AND METHODS OF MAKING THE SAME
ATE373682T1 (en) 2000-03-13 2007-10-15 Biocure Inc EMBOLIC COMPOSITIONS
EP1263802B1 (en) 2000-03-13 2005-11-23 BioCure, Inc. Hydrogel biomedical articles
US6652883B2 (en) 2000-03-13 2003-11-25 Biocure, Inc. Tissue bulking and coating compositions
US7338657B2 (en) * 2001-03-15 2008-03-04 Biosphere Medical, Inc. Injectable microspheres for tissue construction
US6436424B1 (en) * 2000-03-20 2002-08-20 Biosphere Medical, Inc. Injectable and swellable microspheres for dermal augmentation
EP1274472A2 (en) 2000-03-20 2003-01-15 Biosphere Medical, Inc. Injectable and swellable microspheres for tissue bulking
WO2001072281A2 (en) * 2000-03-24 2001-10-04 Biosphere Medical Inc. Microspheres for active embolization
US20030212022A1 (en) * 2001-03-23 2003-11-13 Jean-Marie Vogel Compositions and methods for gene therapy
MY130475A (en) 2000-08-25 2007-06-29 Contura As Polyacrylamide hydrogel and its use as an endoprosthesis
US9017709B2 (en) * 2005-08-11 2015-04-28 Promedon S.A. Composition comprising polymeric, water-insoluble, anionic particles, processes and uses
US20080033366A1 (en) 2006-01-30 2008-02-07 Surgica Corporation Compressible intravascular embolization particles and related methods and delivery systems
EP2368581B1 (en) * 2006-01-30 2018-08-29 Biosphere Medical, Inc. Porous intravascular embolization particles and related methods
WO2007092929A2 (en) 2006-02-09 2007-08-16 Aderans Research Institute, Inc. Apparatus and methods for delivering fluid and material to a subject
US7838035B2 (en) 2006-04-11 2010-11-23 E. I. Du Pont De Nemours And Company Microsphere powder of high density, swellable, deformable, durable occlusion-forming microspheres
US8252339B2 (en) 2006-04-11 2012-08-28 Massachusetts Institute Of Technology Medical treatment applications of swellable and deformable microspheres
US8062673B2 (en) 2006-04-11 2011-11-22 E I Du Pont De Nemours And Company Process for embolization using swellable and deformable microspheres
US7794755B2 (en) 2006-04-11 2010-09-14 E.I. Du Pont De Nemours And Company Process for preparation of swellable and deformable microspheres
US7887846B2 (en) 2007-08-07 2011-02-15 E. I. Du Pont De Nemours And Company Process for preparation of swellable and degradable microspheres
JP2012507562A (en) * 2008-10-30 2012-03-29 ダビド リウ Microspherical porous biocompatible scaffold and manufacturing method and apparatus thereof
EP2351779B1 (en) * 2010-01-27 2019-04-24 Biosphere Medical, Inc. Microspheres and method of making the microspheres
US9232805B2 (en) 2010-06-29 2016-01-12 Biocure, Inc. In-situ forming hydrogel wound dressings containing antimicrobial agents
DK3357520T3 (en) * 2015-09-30 2021-04-06 Univ Jichi Medical VISCOELASTIC COMPOSITION
KR20220148853A (en) 2020-02-28 2022-11-07 조이스 에이치. 마 Formulations and uses thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992006702A1 (en) * 1990-10-19 1992-04-30 New York University A method for transplanting cells into the brain and therapeutic uses therefor
WO1996012510A1 (en) * 1994-10-25 1996-05-02 Boehringer Mannheim Gmbh Biomaterial containing epithelial cells and use thereof as a transplant
US5635215A (en) * 1991-05-29 1997-06-03 Biosepra S.A. Microspheres useful for therapeutic vascular occlusions and injectable solutions containing the same
WO1999044643A1 (en) * 1998-03-06 1999-09-10 Biosepra Medical Inc. Implantable particles for tissue bulking and the treatment of gastroesophageal reflux disease, urinary incontinence, and skin wrinkles

Family Cites Families (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3223083A (en) 1960-09-09 1965-12-14 President And Directors Of Geo Method for adhesively securing together skin and other soft tissue and bone
US3900378A (en) 1971-11-01 1975-08-19 Union Carbide Corp Hydrogels from radiation crosslinked blends of hydrophilic polymers and fillers
US3919411A (en) 1972-01-31 1975-11-11 Bayvet Corp Injectable adjuvant and compositions including such adjuvant
US4197846A (en) 1974-10-09 1980-04-15 Louis Bucalo Method for structure for situating in a living body agents for treating the body
FR2378808A1 (en) 1977-01-28 1978-08-25 Mar Pha Etu Expl Marques NEW HYDROPHILIC COPOLYMERS BASED ON N- (TRIS (HYDROXY-METHYL) METHYL) ACRYLAMIDE OR N- (TRIS (HYDROXYMETHYL) METHYL) METHACRYLAMIDE, THEIR PREPARATION AND THEIR USE IN SEPARATION TECHNIQUES
JPS6040859B2 (en) 1977-07-27 1985-09-12 喜温 三浦 Antithrombotic artificial medical materials
FR2482112B1 (en) 1980-05-09 1985-06-07 Pharmindustrie NOVEL HYDROPHILIC COPOLYMERS BASED ON N- (TRIS (HYDROXYMETHYL) METHYL) ACRYLAMIDE, PROCESSES FOR THEIR PREPARATION, AQUEOUS GELS OF SAID COPOLYMERS AND THEIR USE AS ION EXCHANGERS
NO155805C (en) 1981-02-06 1987-06-10 Ucb Sa ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVITY 2- (4- (DIPHENYLMETHYL) -1-PIPERAZINYL) -ACDIC ACIDS AND THEIR AMIDS AND NON-TOXIC SALTS.
US4413070A (en) 1981-03-30 1983-11-01 California Institute Of Technology Polyacrolein microspheres
US4622362A (en) 1981-03-30 1986-11-11 California Institute Of Technology Polyacrolein microspheres
US4500658A (en) 1983-06-06 1985-02-19 Austenal International, Inc. Radiopaque acrylic resin
CA1225585A (en) * 1983-06-30 1987-08-18 Maria T. Litvinova Composition for embolization of blood vessels
US4786555A (en) 1983-10-27 1988-11-22 E. I. Du Pont De Nemours And Company Support particles coated with or particles of precursors for or of biologically active glass
US4803075A (en) 1986-06-25 1989-02-07 Collagen Corporation Injectable implant composition having improved intrudability
EP0354948A1 (en) 1988-02-12 1990-02-21 DE ZAEPFFEL, Brigitte Crosslinked hydrophilic copolymer for medical and paramedical use
US4956350A (en) 1988-08-18 1990-09-11 Minnesota Mining And Manufacturing Company Wound filling compositions
US5550187A (en) * 1988-11-21 1996-08-27 Collagen Corporation Method of preparing crosslinked biomaterial compositions for use in tissue augmentation
US5162430A (en) 1988-11-21 1992-11-10 Collagen Corporation Collagen-polymer conjugates
US5306500A (en) 1988-11-21 1994-04-26 Collagen Corporation Method of augmenting tissue with collagen-polymer conjugates
US5510418A (en) 1988-11-21 1996-04-23 Collagen Corporation Glycosaminoglycan-synthetic polymer conjugates
DE3841401A1 (en) 1988-12-08 1990-06-13 Martin Lemperle ALLOPLASTIC IMPLANT
US5007940A (en) 1989-06-09 1991-04-16 American Medical Systems, Inc. Injectable polymeric bodies
US5158573A (en) 1989-06-09 1992-10-27 American Medical Systems, Inc. Injectable polymeric bodies
ATE130517T1 (en) * 1990-08-08 1995-12-15 Takeda Chemical Industries Ltd INTRAVASCULAR EMBOLIZING AGENT CONTAINING A SUBSTANCE INHIBITING ANGIOGENESIS.
US5226914A (en) 1990-11-16 1993-07-13 Caplan Arnold I Method for treating connective tissue disorders
EP0529910B1 (en) 1991-08-23 1996-03-13 Nippon Shokubai Co., Ltd. Biodegradable hydrophilic crosslinked polymer, process for producing it, and uses thereof
ZA93506B (en) 1992-02-11 1994-05-11 Bristol Myers Squibb Co Soft tissue augmentation material
US6537574B1 (en) * 1992-02-11 2003-03-25 Bioform, Inc. Soft tissue augmentation material
JP3004724B2 (en) 1992-04-06 2000-01-31 ユーロプラスティ インコーポレイテッド Treatment of reflux obstruction by microparticle injection
JPH0656676A (en) 1992-08-05 1994-03-01 Hori Shinichi Suspension for blood vessel embolization
US5358502A (en) 1993-02-25 1994-10-25 Pfizer Inc PH-triggered osmotic bursting delivery devices
CA2157793C (en) 1993-03-09 1999-07-13 James E. Woiszwillo Macromolecular microparticles and methods of production
CA2158638C (en) 1993-03-19 1999-11-30 Bengt Agerup A composition and a method for tissue augmentation
US5709854A (en) * 1993-04-30 1998-01-20 Massachusetts Institute Of Technology Tissue formation by injecting a cell-polymeric solution that gels in vivo
GB2281861B (en) 1993-09-21 1997-08-20 Johnson & Johnson Medical Bioabsorbable wound implant materials containing microspheres
US5981825A (en) 1994-05-13 1999-11-09 Thm Biomedical, Inc. Device and methods for in vivo culturing of diverse tissue cells
US5451406A (en) 1994-07-14 1995-09-19 Advanced Uroscience, Inc. Tissue injectable composition and method of use
UA10911C2 (en) * 1994-08-10 1996-12-25 Мале Впроваджувальне Підприємство "Іhтерфалл" Biocompatible hydrogel
EP0713707A1 (en) 1994-11-23 1996-05-29 Collagen Corporation In situ crosslinkable, injectable collagen composition for tissue augmention
US5716404A (en) 1994-12-16 1998-02-10 Massachusetts Institute Of Technology Breast tissue engineering
US5919707A (en) 1994-12-22 1999-07-06 Nalco Chemical Company Monitoring of rolling oil emulsions
US5906934A (en) 1995-03-14 1999-05-25 Morphogen Pharmaceuticals, Inc. Mesenchymal stem cells for cartilage repair
US5855610A (en) 1995-05-19 1999-01-05 Children's Medical Center Corporation Engineering of strong, pliable tissues
DE69635127T2 (en) 1995-06-06 2006-06-29 C.R. Bard, Inc. METHOD FOR PRODUCING NETWORKED WATER-SOLUBLE POLYMER PARTICLES, THE PARTICLES AND THEIR USE
US6214331B1 (en) 1995-06-06 2001-04-10 C. R. Bard, Inc. Process for the preparation of aqueous dispersions of particles of water-soluble polymers and the particles obtained
US5830708A (en) 1995-06-06 1998-11-03 Advanced Tissue Sciences, Inc. Methods for production of a naturally secreted extracellular matrix
WO1997015311A1 (en) * 1995-10-20 1997-05-01 L'air Liquide, Societe Anonyme Pour L'etude Et L'exploitation Des Procedes Georges Claude Nitrogen monoxide composition for use as a drug
AU3214797A (en) 1996-05-28 1998-01-05 Regents Of The University Of Michigan, The Engineering oral tissues
US5855615A (en) 1996-06-07 1999-01-05 Menlo Care, Inc. Controller expansion sphincter augmentation media
US5792478A (en) 1996-07-08 1998-08-11 Advanced Uro Science Tissue injectable composition and method of use
US5695480A (en) * 1996-07-29 1997-12-09 Micro Therapeutics, Inc. Embolizing compositions
DE29613806U1 (en) * 1996-08-09 1996-09-26 Stihl Maschf Andreas Hand-held working device with safety link for attaching a safety rope
CA2219605C (en) 1996-10-31 2002-02-05 Deepa Ashok Khambe Method of stimulating gastrointestinal motility with ellagic acid
US6224893B1 (en) 1997-04-11 2001-05-01 Massachusetts Institute Of Technology Semi-interpenetrating or interpenetrating polymer networks for drug delivery and tissue engineering
US5861149A (en) 1997-06-04 1999-01-19 Polyheal Ltd. Methods for wound treatment
GB9727518D0 (en) 1997-12-31 1998-02-25 Nycomed Imaging As Use
US6660301B1 (en) 1998-03-06 2003-12-09 Biosphere Medical, Inc. Injectable microspheres for dermal augmentation and tissue bulking
FR2784580B1 (en) 1998-10-16 2004-06-25 Biosepra Inc POLYVINYL-ALCOHOL MICROSPHERES AND METHODS OF MAKING THE SAME
US6238335B1 (en) 1998-12-11 2001-05-29 Enteric Medical Technologies, Inc. Method for treating gastroesophageal reflux disease and apparatus for use therewith
JP2003517858A (en) * 1999-11-05 2003-06-03 ジェリジーン メディカル コーポレーション Augmentation and repair of age-related soft tissue defects
US7338657B2 (en) 2001-03-15 2008-03-04 Biosphere Medical, Inc. Injectable microspheres for tissue construction
US6436424B1 (en) 2000-03-20 2002-08-20 Biosphere Medical, Inc. Injectable and swellable microspheres for dermal augmentation
EP1274472A2 (en) 2000-03-20 2003-01-15 Biosphere Medical, Inc. Injectable and swellable microspheres for tissue bulking
WO2001072281A2 (en) 2000-03-24 2001-10-04 Biosphere Medical Inc. Microspheres for active embolization
US20030212022A1 (en) 2001-03-23 2003-11-13 Jean-Marie Vogel Compositions and methods for gene therapy
WO2002100444A1 (en) * 2001-06-08 2002-12-19 Biosphere Medical Inc. Colloidal metal labelled microparticles, their production and use
US6911219B2 (en) 2001-09-27 2005-06-28 Surgica Corporation Partially acetalized polyvinyl alcohol embolization particles, compositions containing those particles and methods of making and using them
US7034004B2 (en) * 2002-05-07 2006-04-25 University Of Florida Peptides and methods for the control of obesity
AU2006245950B2 (en) 2005-05-09 2012-01-12 Biosphere Medical S.A. Compositions and methods using microspheres and non-ionic contrast agents
EP2368581B1 (en) 2006-01-30 2018-08-29 Biosphere Medical, Inc. Porous intravascular embolization particles and related methods
US20080033366A1 (en) 2006-01-30 2008-02-07 Surgica Corporation Compressible intravascular embolization particles and related methods and delivery systems
JP2012507562A (en) 2008-10-30 2012-03-29 ダビド リウ Microspherical porous biocompatible scaffold and manufacturing method and apparatus thereof
EP2351779B1 (en) * 2010-01-27 2019-04-24 Biosphere Medical, Inc. Microspheres and method of making the microspheres

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992006702A1 (en) * 1990-10-19 1992-04-30 New York University A method for transplanting cells into the brain and therapeutic uses therefor
US5635215A (en) * 1991-05-29 1997-06-03 Biosepra S.A. Microspheres useful for therapeutic vascular occlusions and injectable solutions containing the same
WO1996012510A1 (en) * 1994-10-25 1996-05-02 Boehringer Mannheim Gmbh Biomaterial containing epithelial cells and use thereof as a transplant
WO1999044643A1 (en) * 1998-03-06 1999-09-10 Biosepra Medical Inc. Implantable particles for tissue bulking and the treatment of gastroesophageal reflux disease, urinary incontinence, and skin wrinkles

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BEAUJEUX REMY ET AL: "Trisacryl gelatin microspheres for therapeutic embolization, II: Preliminary clinical evaluation in tumors and arteriovenous malformations.", AJNR, vol. 17, no. 3, 1996, pages 541 - 548, XP001031874, ISSN: 0195-6108 *
LAURENT ALEXANDRE ET AL: "Trisacryl gelatin microspheres for therapeutic embolization, I: Development and in vitro evaluation.", AJNR, vol. 17, no. 3, 1996, pages 533 - 540, XP001031867, ISSN: 0195-6108 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9040022B2 (en) 2005-05-09 2015-05-26 Biosphere Medical, S.A. Compositions and methods using microspheres and non-ionic contrast agents
US9023380B2 (en) 2005-11-22 2015-05-05 Aderans Research Institute, Inc. Hair follicle graft from tissue engineered skin

Also Published As

Publication number Publication date
US20130323317A1 (en) 2013-12-05
US8932637B2 (en) 2015-01-13
WO2001070289A2 (en) 2001-09-27
US20090186094A1 (en) 2009-07-23
AU2001249221A1 (en) 2001-10-03
US9017710B2 (en) 2015-04-28
EP1274472A2 (en) 2003-01-15

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