WO2001092870A3 - Kit und verfahren zur multianalytbestimmung - Google Patents

Kit und verfahren zur multianalytbestimmung Download PDF

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Publication number
WO2001092870A3
WO2001092870A3 PCT/EP2001/005995 EP0105995W WO0192870A3 WO 2001092870 A3 WO2001092870 A3 WO 2001092870A3 EP 0105995 W EP0105995 W EP 0105995W WO 0192870 A3 WO0192870 A3 WO 0192870A3
Authority
WO
WIPO (PCT)
Prior art keywords
layer
analytes
kit
measuring areas
bonding
Prior art date
Application number
PCT/EP2001/005995
Other languages
English (en)
French (fr)
Other versions
WO2001092870A2 (de
Inventor
Michael Pawlak
Eginhard Schick
Andreas P Abel
Gert L Duveneck
Markus Ehrat
Gerhard M Kresbach
Eveline Schuermann-Mader
Martin A Bopp
Original Assignee
Zeptosens Ag
Michael Pawlak
Eginhard Schick
Andreas P Abel
Gert L Duveneck
Markus Ehrat
Gerhard M Kresbach
Eveline Schuermann-Mader
Martin A Bopp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeptosens Ag, Michael Pawlak, Eginhard Schick, Andreas P Abel, Gert L Duveneck, Markus Ehrat, Gerhard M Kresbach, Eveline Schuermann-Mader, Martin A Bopp filed Critical Zeptosens Ag
Priority to EP01940527A priority Critical patent/EP1287360A2/de
Priority to US10/296,851 priority patent/US7396675B2/en
Priority to JP2002501026A priority patent/JP4812223B2/ja
Priority to AU2001274068A priority patent/AU2001274068A1/en
Publication of WO2001092870A2 publication Critical patent/WO2001092870A2/de
Publication of WO2001092870A3 publication Critical patent/WO2001092870A3/de
Priority to US12/062,820 priority patent/US7645612B2/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
    • G01N2021/6441—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks with two or more labels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6482—Sample cells, cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/808—Optical sensing apparatus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/805—Optical property
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/808—Automated or kit

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Clinical Laboratory Science (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

Die Erfindung betrifft verschiedene Ausführungsformen eines Kits zum gleichzeitigen qualitativen und/oder quantitativen Nachweis einer Vielzahl von Analyten, umfassend: eine Sensorplattform umfassend einen optischen Dünnschichtwellenleiter mit einer bei mindestens einer Anregungswellenlänge transparenten Schicht (a) auf einer bei mindestens dieser Anregungswellenlänge ebenfalls transparenten Schicht (b) mit niedrigerem Brechungsindex als Schicht (a) und mindestens einer in der Schicht (a) modulierten Gitterstruktur (c) zur Einkopplung besagten Anregungslichts in die Schicht (a); mindestens ein Array von in diskreten Messbereichen (d) direkt auf oder über eine Haftvermittlungsschicht auf der Schicht (a) immobilisierten biologischen oder biochemischen oder synthetischen Erkennungselementen zur spezifischen Erkennung und/oder Bindung besagter Analyten und/oder spezifischen Wechselwirkung mit besagten Analyten; Vorkehrungen zur ortsaufgelösten Referenzierung der in den Messbereichen verfügbaren Anregungslichtintensität sowie gegebenenfalls; Vorkehrungen zur Kalibration einer oder mehrerer infolge der Bindung eines oder mehrerer Analyten oder infolge der spezifischen Wechselwirkung mit einem oder mehreren Analyten im Nahfeld der Schicht (a) erzeugten Lumineszenzen, wobei eine auf besagte Analyten zu untersuchende flüssige Probe entweder direkt oder nach Mischung mit weiteren Reagentien mit besagten Messbereichen auf besagter Sensorplattform in Kontakt gebracht wird. Die Erfindung betrifft auch auf dem erfindungsgemässen Kit basierende analytische Systeme sowie damit durchgeführte Verfahren zum Nachweis eines oder mehrerer Analyten und deren Verwendung.
PCT/EP2001/005995 2000-06-02 2001-05-25 Kit und verfahren zur multianalytbestimmung WO2001092870A2 (de)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP01940527A EP1287360A2 (de) 2000-06-02 2001-05-25 Kit und verfahren zur multianalytbestimmung
US10/296,851 US7396675B2 (en) 2000-06-02 2001-05-25 Kit and method for determining a plurality of analytes
JP2002501026A JP4812223B2 (ja) 2000-06-02 2001-05-25 多分析対象物測定のためのキット及び方法
AU2001274068A AU2001274068A1 (en) 2000-06-02 2001-05-25 Kit and method for determining a plurality of analytes
US12/062,820 US7645612B2 (en) 2000-06-02 2008-04-04 Kit and method for multi-analyte determination

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH11042000 2000-06-02
CH20001104/00 2000-06-02

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10296851 A-371-Of-International 2001-05-25
US12/062,820 Division US7645612B2 (en) 2000-06-02 2008-04-04 Kit and method for multi-analyte determination

Publications (2)

Publication Number Publication Date
WO2001092870A2 WO2001092870A2 (de) 2001-12-06
WO2001092870A3 true WO2001092870A3 (de) 2002-10-03

Family

ID=4557675

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/005995 WO2001092870A2 (de) 2000-06-02 2001-05-25 Kit und verfahren zur multianalytbestimmung

Country Status (5)

Country Link
US (2) US7396675B2 (de)
EP (1) EP1287360A2 (de)
JP (1) JP4812223B2 (de)
AU (1) AU2001274068A1 (de)
WO (1) WO2001092870A2 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9134307B2 (en) 2007-07-11 2015-09-15 X-Body, Inc. Method for determining ion channel modulating properties of a test reagent

Families Citing this family (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6771376B2 (en) * 1999-07-05 2004-08-03 Novartis Ag Sensor platform, apparatus incorporating the platform, and process using the platform
US7167615B1 (en) 1999-11-05 2007-01-23 Board Of Regents, The University Of Texas System Resonant waveguide-grating filters and sensors and methods for making and using same
US8111401B2 (en) 1999-11-05 2012-02-07 Robert Magnusson Guided-mode resonance sensors employing angular, spectral, modal, and polarization diversity for high-precision sensing in compact formats
US7615339B2 (en) * 2000-10-30 2009-11-10 Sru Biosystems, Inc. Method for producing a colorimetric resonant reflection biosensor on rigid surfaces
US20030092075A1 (en) * 2000-10-30 2003-05-15 Sru Biosystems, Llc Aldehyde chemical surface activation processes and test methods for colorimetric resonant sensors
US7575939B2 (en) 2000-10-30 2009-08-18 Sru Biosystems, Inc. Optical detection of label-free biomolecular interactions using microreplicated plastic sensor elements
US7101660B2 (en) * 2000-10-30 2006-09-05 Sru Biosystems, Inc. Method for producing a colorimetric resonant reflection biosensor on rigid surfaces
US7300803B2 (en) * 2000-10-30 2007-11-27 Sru Biosystems, Inc. Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor
US6951715B2 (en) * 2000-10-30 2005-10-04 Sru Biosystems, Inc. Optical detection of label-free biomolecular interactions using microreplicated plastic sensor elements
US7202076B2 (en) * 2000-10-30 2007-04-10 Sru Biosystems, Inc. Label-free high-throughput optical technique for detecting biomolecular interactions
US7023544B2 (en) * 2000-10-30 2006-04-04 Sru Biosystems, Inc. Method and instrument for detecting biomolecular interactions
US7153702B2 (en) * 2000-10-30 2006-12-26 Sru Biosystems, Inc. Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor
US7217574B2 (en) * 2000-10-30 2007-05-15 Sru Biosystems, Inc. Method and apparatus for biosensor spectral shift detection
US7524625B2 (en) 2000-10-30 2009-04-28 Sru Biosystems, Inc. Real time binding analysis of antigens on a biosensor surface
US7875434B2 (en) * 2000-10-30 2011-01-25 Sru Biosystems, Inc. Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor
US7118710B2 (en) * 2000-10-30 2006-10-10 Sru Biosystems, Inc. Label-free high-throughput optical technique for detecting biomolecular interactions
US7264973B2 (en) * 2000-10-30 2007-09-04 Sru Biosystems, Inc. Label-free methods for performing assays using a colorimetric resonant optical biosensor
US7175980B2 (en) * 2000-10-30 2007-02-13 Sru Biosystems, Inc. Method of making a plastic colorimetric resonant biosensor device with liquid handling capabilities
US7142296B2 (en) * 2000-10-30 2006-11-28 Sru Biosystems, Inc. Method and apparatus for detecting biomolecular interactions
US20030113766A1 (en) * 2000-10-30 2003-06-19 Sru Biosystems, Llc Amine activated colorimetric resonant biosensor
US7371562B2 (en) * 2000-10-30 2008-05-13 Sru Biosystems, Inc. Guided mode resonant filter biosensor using a linear grating surface structure
US7070987B2 (en) * 2000-10-30 2006-07-04 Sru Biosystems, Inc. Guided mode resonant filter biosensor using a linear grating surface structure
US7306827B2 (en) * 2000-10-30 2007-12-11 Sru Biosystems, Inc. Method and machine for replicating holographic gratings on a substrate
GB0124338D0 (en) * 2001-10-10 2001-11-28 Randox Lab Ltd Biochips
AU2002357547A1 (en) * 2001-12-13 2003-06-23 Zeptosens Ag Optically transparent substrate for a maldi measuring system and the use thereof
AU2003210523B2 (en) * 2002-01-28 2008-03-20 Sru Biosystems, Inc. A guided mode resonant filter biosensor using a linear grating surface structure
AU2008202728B2 (en) * 2002-01-28 2011-04-07 Sru Biosystems, Inc. A guided mode resonant filter biosensor using a linear grating surface structure
US7074311B1 (en) 2002-05-08 2006-07-11 Sru Biosystems Inc. Biosensor electrophoresis
WO2003096018A2 (de) * 2002-05-13 2003-11-20 Zeptosens Ag Kit zur assay-entwicklung und für serien-analysen
EP1509593B1 (de) * 2002-06-05 2007-08-15 Bioprocessors Corporation Verfahren enhaltend reaktoren mit einem beleuchteten bauelement
JP2005537486A (ja) * 2002-09-03 2005-12-08 ツェプトゼンス　アクチエンゲゼルシャフト 分析対象物が試料中で固定化された特異的結合パートナーとして測定される分析プラットフォーム及び検出法
WO2004023143A2 (de) * 2002-09-03 2004-03-18 Zeptosens Ag Analytische plattform und nachweisverfahren
US7429492B2 (en) * 2002-09-09 2008-09-30 Sru Biosystems, Inc. Multiwell plates with integrated biosensors and membranes
US7927822B2 (en) * 2002-09-09 2011-04-19 Sru Biosystems, Inc. Methods for screening cells and antibodies
US20030153013A1 (en) * 2002-11-07 2003-08-14 Ruo-Pan Huang Antibody-based protein array system
US7309614B1 (en) 2002-12-04 2007-12-18 Sru Biosystems, Inc. Self-referencing biodetection method and patterned bioassays
US20040254479A1 (en) 2003-02-20 2004-12-16 John Fralick Bio-photonic feedback control software and database
US7522762B2 (en) * 2003-04-16 2009-04-21 Inverness Medical-Biostar, Inc. Detection, resolution, and identification of arrayed elements
US9317922B2 (en) * 2003-05-16 2016-04-19 Board Of Regents The University Of Texas System Image and part recognition technology
US7413893B2 (en) * 2003-06-09 2008-08-19 Perkinelmer Las, Inc. Methods, apparatus and compositions for improved measurements with optical biosensors
US7545494B2 (en) * 2003-07-23 2009-06-09 Bayer Technology Services Gmbh Analytical system and method for analyzing nonlinear optical signals
US8298780B2 (en) 2003-09-22 2012-10-30 X-Body, Inc. Methods of detection of changes in cells
US20050214803A1 (en) * 2003-11-06 2005-09-29 Sru Biosystems, Llc High-density amine-functionalized surface
EP1564556A1 (de) * 2004-02-17 2005-08-17 DST Diagnostic Science & Technology GmbH Verfahren und Vorrichtung zur Bestimmung mehrerer Analyten mit simultaner interner Kontrolle
US20050197581A1 (en) * 2004-02-19 2005-09-08 Scott Ferguson Bio-photonic-scanning calibration method
US20050278184A1 (en) 2004-06-10 2005-12-15 John Fralick Bio-photonic feedback control software and database
WO2005095965A1 (en) * 2004-03-03 2005-10-13 Bayer Technology Services Gmbh Analytical platform and method for generating protein expression profiles of cell populations
WO2005118884A1 (en) * 2004-05-28 2005-12-15 The United States Of America As Represented By The Secretary Of The Navy A method for the rapid diagnosis of infectious disease by detection and quantitation of microorganism induced cytokines
US20050266398A1 (en) * 2004-06-01 2005-12-01 Peter Lea Method and device for rapid detection and quantitation of macro and micro matrices
CA2475240A1 (en) * 2004-07-20 2006-01-20 Biophys, Inc. Method and device to measure dynamic internal calibration true dose response curves
CA2475456A1 (en) 2004-07-20 2006-01-20 Biophys, Inc. Method and device to optimize analyte and antibody substrate binding by least energy adsorption
CA2579150C (en) * 2004-09-17 2014-11-25 Pacific Biosciences Of California, Inc. Apparatus and method for analysis of molecules
US7170050B2 (en) * 2004-09-17 2007-01-30 Pacific Biosciences Of California, Inc. Apparatus and methods for optical analysis of molecules
US20060275825A1 (en) * 2005-04-12 2006-12-07 Sru Biosystems, Inc. Proteolipid membrane and lipid membrane biosensor
EP1946161A2 (de) * 2005-09-08 2008-07-23 Georgia Technology Research Corporation Dünnfilm-wellenleiter, herstellungsverfahren dafür und detektionssysteme
JP5127718B2 (ja) 2005-10-29 2013-01-23 バイエル・テクノロジー・サービシズ・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング 複雑な組成を有する生物学的起源のサンプル中の１種若しくはそれ以上の被検体の測定方法およびその使用
DE102005062377A1 (de) * 2005-12-23 2007-06-28 Bayer Technology Services Gmbh Vorrichtung und Verfahren zum Nachweis von Mykotoxinen
US9976192B2 (en) 2006-03-10 2018-05-22 Ldip, Llc Waveguide-based detection system with scanning light source
US9423397B2 (en) 2006-03-10 2016-08-23 Indx Lifecare, Inc. Waveguide-based detection system with scanning light source
US8288157B2 (en) 2007-09-12 2012-10-16 Plc Diagnostics, Inc. Waveguide-based optical scanning systems
US9528939B2 (en) 2006-03-10 2016-12-27 Indx Lifecare, Inc. Waveguide-based optical scanning systems
EP2018541A2 (de) * 2006-05-17 2009-01-28 Siemens Healthcare Diagnostics Inc. Verfahren zur signalintensitätskorrektur in wellenleitersensoren
CN101646943A (zh) * 2006-10-31 2010-02-10 Sru生物系统公司 阻断官能化表面上的非特异性蛋白结合的方法
EP2153203A4 (de) * 2007-04-19 2010-04-21 Sru Biosystems Inc Verfahren zum einsatz eines biosensors zum nachweis kleiner moleküle, die direkt an immobilisierte ziele binden
AU2008274978A1 (en) 2007-07-11 2009-01-15 Sru Biosystems, Inc. Methods of identifying modulators of ion channels
WO2009048833A1 (en) * 2007-10-09 2009-04-16 Siemens Healthcare Diagnostics Inc. Two dimensional imaging of reacted areas on a reagent
CA2991818C (en) 2008-03-28 2022-10-11 Pacific Biosciences Of California, Inc. Compositions and methods for nucleic acid sequencing
US8257936B2 (en) 2008-04-09 2012-09-04 X-Body Inc. High resolution label free analysis of cellular properties
US20100015721A1 (en) * 2008-06-04 2010-01-21 Sru Biosystems, Inc. Detection of Promiscuous Small Submicrometer Aggregates
GB2461026B (en) 2008-06-16 2011-03-09 Plc Diagnostics Inc System and method for nucleic acids sequencing by phased synthesis
EP2380038B1 (de) * 2008-12-22 2019-01-09 Koninklijke Philips N.V. Cmos bildaufnehmer
KR20100111098A (ko) * 2009-04-06 2010-10-14 삼성전자주식회사 마이크로어레이의 데이터 스팟의 위치를 검출하는 방법 및 장치
EP2425286B1 (de) 2009-04-29 2020-06-24 Ldip, Llc Auf wellenleitern basierendes detektionssystem mit abtastlichtquelle
WO2010132890A1 (en) * 2009-05-15 2010-11-18 Sru Biosystems, Inc Detection of changes in cell populations and mixed cell populations
CN101988893B (zh) 2009-07-31 2012-02-08 长春吉大·小天鹅仪器有限公司 48通道阵列式等吸收波长检测系统
CN102687018B (zh) 2009-11-16 2015-07-15 硅生物装置有限公司 化验用过滤装置
CA2795554C (en) 2010-04-06 2021-07-13 Massachusetts Institute Of Technology Gene-expression profiling with reduced numbers of transcript measurements
US9538880B2 (en) * 2012-05-09 2017-01-10 Convotherm Elektrogeraete Gmbh Optical quality control system
KR20130127261A (ko) 2012-05-14 2013-11-22 삼성전자주식회사 반도체 장치 및 그 제조 방법
US9157910B2 (en) 2013-03-15 2015-10-13 Abbott Laboratories Assay with increased dynamic range
US9005901B2 (en) 2013-03-15 2015-04-14 Abbott Laboratories Assay with internal calibration
JPWO2014196606A1 (ja) * 2013-06-05 2017-02-23 国立研究開発法人物質・材料研究機構 抗体または抗原を固定化した膜型表面応力センサとその製造方法並びにこれを用いた免疫測定方法
US10018566B2 (en) 2014-02-28 2018-07-10 Ldip, Llc Partially encapsulated waveguide based sensing chips, systems and methods of use
WO2016138427A1 (en) 2015-02-27 2016-09-01 Indx Lifecare, Inc. Waveguide-based detection system with scanning light source
CN106248224B (zh) * 2015-06-09 2020-04-14 松下知识产权经营株式会社 光检测装置以及光检测系统
TWI794145B (zh) 2015-10-28 2023-03-01 美商加州太平洋生物科學公司 包含整合性帶通濾波器之光學裝置陣列
EP3315963A1 (de) * 2016-10-26 2018-05-02 Fuchs Petrolub SE Probenaufnahmeelement, analysenset und verfahren zur analyse eines liquids, insbesondere einer kühlschmierstoffemulsion
RU2699943C1 (ru) * 2019-01-18 2019-09-11 Общество с ограниченной ответственностью "Метромед" Планшет для тестирования иммуноферментных анализаторов
CN112439393A (zh) * 2020-11-17 2021-03-05 吉林化工学院 一种核酸印迹磁珠的制备方法及其应用
CN116899644B (zh) * 2023-09-12 2023-11-28 微纳动力(北京)科技有限责任公司 一种光电微流控装置及系统

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997035181A1 (en) * 1996-03-19 1997-09-25 University Of Utah Research Foundation System for determining analyte concentration
WO1998029736A1 (en) * 1996-12-31 1998-07-09 Genometrix Incorporated Multiplexed molecular analysis apparatus and method
US5874219A (en) * 1995-06-07 1999-02-23 Affymetrix, Inc. Methods for concurrently processing multiple biological chip assays

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK590288D0 (da) * 1988-10-24 1988-10-24 Symbicom Ab Kemiske forbindelser
IL68506A (en) 1982-05-04 1988-06-30 Syva Co Simultaneous calibration heterogeneous immunoassay method and device and kit for use therein
AU1944283A (en) 1982-08-27 1984-03-29 Ekins Roger Philip Measurement of analyte concentration
JPH0627703B2 (ja) * 1985-05-29 1994-04-13 アーティフィシャル センシング インスツルメンツ エイエスアイ アクチェンゲゼルシャフト 物質の選択的検出および測定物質内の屈折率変化検知を行なう光学センサ
US5807755A (en) 1987-08-06 1998-09-15 Multilyte Limited Determination of ambient concentrations of several analytes
GB8803000D0 (en) 1988-02-10 1988-03-09 Ekins Roger Philip Determination of ambient concentrations of several analytes
DE59109246D1 (de) * 1990-05-03 2003-04-03 Hoffmann La Roche Mikrooptischer Sensor
US5604105B1 (en) 1990-10-12 1999-08-24 Spectral Diagnostics Inc Method and device for diagnosingand distinguishing chest pain in early onset thereof
CA2069537A1 (en) 1991-06-07 1992-12-08 Thomas A. Cook Multiple output referencing system for evanescent wave sensor
GB9212302D0 (en) 1992-06-10 1992-07-22 Applied Research Systems Method for improving measurement precision in evanescent wave optical biosensor assays
GB9314991D0 (en) * 1993-07-20 1993-09-01 Sandoz Ltd Mechanical device
GB9326450D0 (en) 1993-12-24 1994-02-23 Multilyte Ltd Binding assay
CA2190362A1 (en) 1994-05-27 1995-12-07 Gert L. Duveneck Process for detecting evanescently excited luminescence
US5814565A (en) * 1995-02-23 1998-09-29 University Of Utah Research Foundation Integrated optic waveguide immunosensor
US5961923A (en) * 1995-04-25 1999-10-05 Irori Matrices with memories and uses thereof
PL323257A1 (en) 1995-05-12 1998-03-16 Ciba Geigy Ag Detection platform for simultaneously detecting plurality of analytes using hypercritically excited luminescence
WO1997035176A1 (en) * 1996-03-19 1997-09-25 University Of Utah Research Foundation Lens and associatable flow cell
DE59712460D1 (de) 1996-11-18 2005-12-01 Novartis Ag Messvorrichtung mit einem planaren optischen wellenleiter
US6485690B1 (en) * 1999-05-27 2002-11-26 Orchid Biosciences, Inc. Multiple fluid sample processor and system
US6653151B2 (en) * 1999-07-30 2003-11-25 Large Scale Proteomics Corporation Dry deposition of materials for microarrays using matrix displacement

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5874219A (en) * 1995-06-07 1999-02-23 Affymetrix, Inc. Methods for concurrently processing multiple biological chip assays
WO1997035181A1 (en) * 1996-03-19 1997-09-25 University Of Utah Research Foundation System for determining analyte concentration
WO1998029736A1 (en) * 1996-12-31 1998-07-09 Genometrix Incorporated Multiplexed molecular analysis apparatus and method

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
MENDOZA L G ET AL: "HIGH-THROUGHPUT MICROARRAY-BASED ENZYME-LINKED IMMUNOSORBENT ASSAY (ELISA)", BIOTECHNIQUES, EATON PUBLISHING, NATICK, US, vol. 27, no. 4, October 1999 (1999-10-01), pages 778,780,782 - 786,788, XP000992893, ISSN: 0736-6205 *
PLOWMAN T E ET AL: "MULTIPLE-ANALYTE FLUOROIMMUNOASSAY USING AN INTEGRATED OPTICAL WAVEGUIDE SENSOR", ANALYTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. COLUMBUS, US, vol. 71, no. 19, 1 October 1999 (1999-10-01), pages 4344 - 4352, XP000854131, ISSN: 0003-2700 *
ROWE C A ET AL: "ARRAY BIOSENSOR FOR SIMULTANEOUSLY IDENTIFICATION OF BACTERIAL, VIRAL, AND PROTEIN ANALYTES", ANALYTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. COLUMBUS, US, vol. 71, 1999, pages 3846 - 3852, XP000996992, ISSN: 0003-2700 *
SCHICK E ET AL: "Ultrasensitive multianalyte immunoassays: The synergy between planar waveguide- and microarray technology.", EUROPEAN BIOPHYSICS JOURNAL, vol. 29, no. 4-5, 22 August 2000 (2000-08-22), 3rd European Biophysics Congress;Munchen, Germany; September 09-13, 2000, pages 379, XP002205023, ISSN: 0175-7571 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9134307B2 (en) 2007-07-11 2015-09-15 X-Body, Inc. Method for determining ion channel modulating properties of a test reagent

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US7645612B2 (en) 2010-01-12
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