WO2001095874A3 - Highly efficient delivery of a large therapeutic mass aerosol - Google Patents
Highly efficient delivery of a large therapeutic mass aerosol Download PDFInfo
- Publication number
- WO2001095874A3 WO2001095874A3 PCT/US2001/018491 US0118491W WO0195874A3 WO 2001095874 A3 WO2001095874 A3 WO 2001095874A3 US 0118491 W US0118491 W US 0118491W WO 0195874 A3 WO0195874 A3 WO 0195874A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- particles
- agent
- highly efficient
- efficient delivery
- large therapeutic
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
- A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
Abstract
Priority Applications (15)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK01942072T DK1296663T3 (en) | 2000-06-09 | 2001-06-08 | Very effective delivery of an aerosol with great therapeutic mass |
AU2001275368A AU2001275368B2 (en) | 2000-06-09 | 2001-06-08 | Highly efficient delivery of a large therapeutic mass aerosol |
PL36028701A PL360287A1 (en) | 2000-06-09 | 2001-06-08 | Highly efficient delivery of a large therapeutic mass aerosol |
MXPA02012023A MXPA02012023A (en) | 2000-06-09 | 2001-06-08 | Highly efficient delivery of a large therapeutic mass aerosol. |
AU7536801A AU7536801A (en) | 2000-06-09 | 2001-06-08 | Highly efficient delivery of a large therapeutic mass aerosol |
DE60127407T DE60127407T2 (en) | 2000-06-09 | 2001-06-08 | HIGH-ACTIVE ADMINISTRATION OF AEROSOL WITH HIGH THERAPEUTIC MASS |
NZ523254A NZ523254A (en) | 2000-06-09 | 2001-06-08 | Method of delivering a large therapeutic mass aerosol to the pulmonary system |
CA002412561A CA2412561C (en) | 2000-06-09 | 2001-06-08 | Highly efficient delivery of a large therapeutic mass aerosol |
JP2002510053A JP2004503482A (en) | 2000-06-09 | 2001-06-08 | Highly efficient delivery of large therapeutic mass aerosols |
SI200130734T SI1296663T1 (en) | 2000-06-09 | 2001-06-08 | Highly efficient delivery of a large therapeutic mass aerosol |
KR1020027016748A KR100697479B1 (en) | 2000-06-09 | 2001-06-08 | Highly efficient delivery of a large therapeutic mass aerosol |
IL15328101A IL153281A0 (en) | 2000-06-09 | 2001-06-08 | Highly efficient delivery of a large therapeutic mass aerosol |
EP01942072A EP1296663B1 (en) | 2000-06-09 | 2001-06-08 | Highly efficient delivery of a large therapeutic mass aerosol |
NO20025873A NO20025873L (en) | 2000-06-09 | 2002-12-06 | Very effective delivery of a large therapeutic amount of aerosol |
HK03103294A HK1051139A1 (en) | 2000-06-09 | 2003-05-12 | Highly efficient delivery of a large therapeutic mass aerosol |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/591,307 | 2000-06-09 | ||
US09/591,307 US6858199B1 (en) | 2000-06-09 | 2000-06-09 | High efficient delivery of a large therapeutic mass aerosol |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2001095874A2 WO2001095874A2 (en) | 2001-12-20 |
WO2001095874A3 true WO2001095874A3 (en) | 2003-01-16 |
Family
ID=24365965
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/018491 WO2001095874A2 (en) | 2000-06-09 | 2001-06-08 | Highly efficient delivery of a large therapeutic mass aerosol |
Country Status (21)
Country | Link |
---|---|
US (6) | US6858199B1 (en) |
EP (2) | EP1296663B1 (en) |
JP (2) | JP2004503482A (en) |
KR (1) | KR100697479B1 (en) |
CN (1) | CN100589796C (en) |
AT (1) | ATE357222T1 (en) |
AU (2) | AU2001275368B2 (en) |
CA (1) | CA2412561C (en) |
DE (1) | DE60127407T2 (en) |
DK (1) | DK1296663T3 (en) |
ES (1) | ES2283417T3 (en) |
HK (1) | HK1051139A1 (en) |
IL (1) | IL153281A0 (en) |
MX (1) | MXPA02012023A (en) |
NO (1) | NO20025873L (en) |
NZ (1) | NZ523254A (en) |
PL (1) | PL360287A1 (en) |
PT (1) | PT1296663E (en) |
RU (1) | RU2275900C2 (en) |
SI (1) | SI1296663T1 (en) |
WO (1) | WO2001095874A2 (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8877162B2 (en) | 2000-05-10 | 2014-11-04 | Novartis Ag | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery |
US8992983B2 (en) | 2010-08-30 | 2015-03-31 | Pulmatrix, Inc. | Respirably dry powder comprising calcium lactate, sodium chloride and leucine |
US9061352B2 (en) | 2010-08-30 | 2015-06-23 | Pulmatrix, Inc. | Dry powder formulations and methods for treating pulmonary diseases |
US9421166B2 (en) | 2001-12-19 | 2016-08-23 | Novartis Ag | Pulmonary delivery of aminoglycoside |
US9433576B2 (en) | 2010-09-29 | 2016-09-06 | Pulmatrix, Inc. | Cationic dry powders |
US9554993B2 (en) | 1997-09-29 | 2017-01-31 | Novartis Ag | Pulmonary delivery particles comprising an active agent |
Families Citing this family (102)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020017295A1 (en) * | 2000-07-07 | 2002-02-14 | Weers Jeffry G. | Phospholipid-based powders for inhalation |
US20060171899A1 (en) * | 1998-12-10 | 2006-08-03 | Akwete Adjei | Water-stabilized aerosol formulation system and method of making |
US6858199B1 (en) * | 2000-06-09 | 2005-02-22 | Advanced Inhalation Research, Inc. | High efficient delivery of a large therapeutic mass aerosol |
US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
US6749835B1 (en) * | 1999-08-25 | 2004-06-15 | Advanced Inhalation Research, Inc. | Formulation for spray-drying large porous particles |
US6613308B2 (en) | 2000-09-19 | 2003-09-02 | Advanced Inhalation Research, Inc. | Pulmonary delivery in treating disorders of the central nervous system |
US6514482B1 (en) | 2000-09-19 | 2003-02-04 | Advanced Inhalation Research, Inc. | Pulmonary delivery in treating disorders of the central nervous system |
WO2002032396A2 (en) * | 2000-10-16 | 2002-04-25 | Massachusetts Institute Of Technology | Lipid-protein-sugar particles for delivery of nucleic acids |
AU2002316574B2 (en) * | 2002-03-15 | 2008-05-01 | Brandeis University | Central airway administration for systemic delivery of therapeutics |
WO2003079992A2 (en) * | 2002-03-20 | 2003-10-02 | Advanced Inhalation Research, Inc. | Pulmonary delivery for levodopa |
US7008644B2 (en) * | 2002-03-20 | 2006-03-07 | Advanced Inhalation Research, Inc. | Method and apparatus for producing dry particles |
ES2718455T3 (en) | 2002-03-20 | 2019-07-02 | Civitas Therapeutics Inc | Inhaled sustained therapeutic formulations |
ES2300568T3 (en) | 2002-03-20 | 2008-06-16 | Mannkind Corporation | INHALATION APPARATUS |
US6930137B2 (en) * | 2002-05-31 | 2005-08-16 | Fina Technology, Inc. | Method of improving blown film processing performance and physical properties |
SI1531794T1 (en) * | 2002-06-28 | 2017-12-29 | Civitas Therapeteutics, Inc. | Inhalable epinephrine |
AU2003232081B2 (en) * | 2002-07-03 | 2009-02-05 | Brandeis University | Central airway administration for systemic delivery of therapeutics |
US6966990B2 (en) * | 2002-10-11 | 2005-11-22 | Ferro Corporation | Composite particles and method for preparing |
RU2364400C2 (en) * | 2003-04-14 | 2009-08-20 | Вектура Лтд | Pharmaceutical compositions |
US20040204439A1 (en) * | 2003-04-14 | 2004-10-14 | Staniforth John Nicholas | Composition, device, and method for treating sexual dysfunction via inhalation |
US20060147389A1 (en) * | 2004-04-14 | 2006-07-06 | Vectura Ltd. | Devices and pharmaceutical compositions for enhancing dosing efficiency |
DE10317461A1 (en) * | 2003-04-16 | 2004-10-28 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Preparing microparticles labeled with technetium, useful as powders for inhalation, e.g. to study deposition of pharmaceuticals, such as anticholinergic agents, involves incubation with solution of technetium salt |
GB0313604D0 (en) * | 2003-06-12 | 2003-07-16 | Britannia Pharmaceuticals Ltd | Delivery device for powdered medicament |
ES2872350T3 (en) | 2003-06-13 | 2021-11-02 | Civitas Therapeutics Inc | Low Dose Pharmaceutical Powders For Inhalation |
EP1663159A4 (en) * | 2003-09-10 | 2010-06-09 | Map Pharmaceuticals Inc | Aerosol formulations for delivery of dihydroergotamine to the systemic circulation via pulmonary inhalation |
GB0327723D0 (en) | 2003-09-15 | 2003-12-31 | Vectura Ltd | Pharmaceutical compositions |
WO2005077338A1 (en) * | 2004-02-10 | 2005-08-25 | Advanced Inhalation Research, Inc. | Particles for inhalation rapid release properties |
CN101098678A (en) * | 2004-04-23 | 2008-01-02 | 锡德克斯公司 | Dpi formulation containing sulfoalkyl ether cyclodextrin |
MX2007001903A (en) | 2004-08-20 | 2007-08-02 | Mannkind Corp | Catalysis of diketopiperazine synthesis. |
KR101306384B1 (en) | 2004-08-23 | 2013-09-09 | 맨카인드 코포레이션 | Diketopiperazine salts, diketomorpholine salts or diketodioxane salts for drug delivery |
SE0402345L (en) * | 2004-09-24 | 2006-03-25 | Mederio Ag | Measured drug dose |
GB0425758D0 (en) | 2004-11-23 | 2004-12-22 | Vectura Ltd | Preparation of pharmaceutical compositions |
US20060134009A1 (en) * | 2004-12-16 | 2006-06-22 | Daniel Deaver | Low dose corticosteroid powders for inhalation |
EP2402001A1 (en) * | 2005-05-18 | 2012-01-04 | Pulmatrix, Inc. | Formulations for alteration of biophysical properties of mucosal lining |
RU2008108510A (en) * | 2005-08-11 | 2009-09-20 | Президент Энд Феллоуз Гарвард Колледж (Us) | METHODS AND COMPOSITIONS OF DRIED CELL FORMS |
JP5465878B2 (en) | 2005-09-14 | 2014-04-09 | マンカインド コーポレイション | Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents |
US7629331B2 (en) | 2005-10-26 | 2009-12-08 | Cydex Pharmaceuticals, Inc. | Sulfoalkyl ether cyclodextrin compositions and methods of preparation thereof |
US20070123449A1 (en) * | 2005-11-01 | 2007-05-31 | Advanced Inhalation Research, Inc. | High load particles for inhalation having rapid release properties |
WO2009074634A2 (en) * | 2007-12-13 | 2009-06-18 | Glaxo Group Limited | Compositions for pulmonary delivery |
CN104383546B (en) | 2006-02-22 | 2021-03-02 | 曼金德公司 | Method for improving the pharmaceutical properties of microparticles comprising diketopiperazines and an active agent |
GB0616299D0 (en) * | 2006-08-16 | 2006-09-27 | Cambridge Consultants | Drug Capsules for dry power inhalers |
EP2086617A4 (en) | 2006-10-26 | 2013-11-20 | Next Breath Llc | Phospholipid-based inhalation system |
US20080260852A1 (en) * | 2007-01-23 | 2008-10-23 | Ferro Pfanstiehl Laboratories, Inc. | Supercritical fluid extraction produced by in-line homogenization |
US7745566B2 (en) * | 2007-01-23 | 2010-06-29 | Ferro Corporation | Methods for the purification of polymers |
KR20090129998A (en) | 2007-02-11 | 2009-12-17 | 맵 파마슈티컬스, 인코포레이티드 | Method of therapeutic administration of dhe to enable rapid relief of migraine while minimizing side effect profile |
JP2010527914A (en) * | 2007-04-26 | 2010-08-19 | クォーク ファーマシューティカルズ インコーポレーティッド | Therapeutic delivery of inhibitory nucleic acid molecules to the respiratory system |
EP2219613A1 (en) * | 2007-10-26 | 2010-08-25 | Università degli Studi di Parma | Compositions in powder form made of soft agglomerates of a micronized drug and of a two-components excipient, and process for their preparation |
GB0721394D0 (en) * | 2007-10-31 | 2007-12-12 | Vectura Group Plc | Compositions for trating parkinson's disease |
WO2009082343A1 (en) * | 2007-12-20 | 2009-07-02 | Astrazeneca Ab | Dispenser and method for entraining powder in an airflow 537 |
US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
CN104689432B (en) | 2008-06-13 | 2018-07-06 | 曼金德公司 | Diskus and the system for drug conveying |
JP5479465B2 (en) | 2008-06-20 | 2014-04-23 | マンカインド コーポレイション | Interactive device and method for profiling inhalation efforts in real time |
RU2508093C2 (en) * | 2008-07-01 | 2014-02-27 | Нитто Денко Корпорейшн | Pharmaceutical composition containing coated microparticles |
EP2328556A4 (en) * | 2008-07-30 | 2013-11-20 | Stc Unm | Formulations containing large-size carrier particles for dry powder inhalation aerosols |
TWI494123B (en) | 2008-08-11 | 2015-08-01 | Mannkind Corp | Use of ultrarapid acting insulin |
US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
CA2753645C (en) | 2009-02-27 | 2016-07-26 | Pari Pharma Gmbh | Method for operating an aerosol inhalation device and aerosol inhalation device |
PL2405963T3 (en) | 2009-03-11 | 2014-04-30 | Mannkind Corp | Apparatus, system and method for measuring resistance of an inhaler |
JP5671001B2 (en) | 2009-03-26 | 2015-02-18 | パルマトリックス,インコーポレイテッド | Dry powder formulation and method for treating lung disease |
GB0908129D0 (en) * | 2009-05-12 | 2009-06-24 | Innovata Ltd | Composition |
EP2440184B1 (en) | 2009-06-12 | 2023-04-05 | MannKind Corporation | Diketopiperazine microparticles with defined specific surface areas |
WO2010151804A1 (en) * | 2009-06-26 | 2010-12-29 | Map Pharmaceuticals, Inc. | Administration of dihydroergotamine mesylate particles using a metered dose inhaler |
WO2011056889A1 (en) | 2009-11-03 | 2011-05-12 | Mannkind Corporation | An apparatus and method for simulating inhalation efforts |
EP2380618A1 (en) * | 2010-04-26 | 2011-10-26 | PARI Pharma GmbH | Operating method for an aerosol delivery device and aerosol delivery device |
RU2571331C1 (en) | 2010-06-21 | 2015-12-20 | Маннкайнд Корпорейшн | Systems and methods for dry powder drug delivery |
MX354828B (en) | 2010-09-29 | 2018-03-22 | Pulmatrix Operating Co Inc | Monovalent metal cation dry powders for inhalation. |
DK2694402T3 (en) | 2011-04-01 | 2017-07-03 | Mannkind Corp | BLISTER PACKAGE FOR PHARMACEUTICAL CYLINDER AMPULS |
WO2012174472A1 (en) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | High capacity diketopiperazine microparticles |
AU2012328885B2 (en) | 2011-10-24 | 2017-08-31 | Mannkind Corporation | Methods and compositions for treating pain |
PT106094A (en) | 2012-01-13 | 2013-07-15 | Hovione Farmaciencia S A | ADMINISTRATION BY INHALATION OF FORMULATIONS WITH HIGH DOSE |
CN107596518B (en) | 2012-02-29 | 2021-04-23 | 普马特里克斯营业公司 | Inhalable dry powder |
AU2013289957B2 (en) | 2012-07-12 | 2017-02-23 | Mannkind Corporation | Dry powder drug delivery systems and methods |
RU2495682C1 (en) * | 2012-07-12 | 2013-10-20 | Дарья Сергеевна Петренко | Method for drug delivery in treating or preventing tobacco smoking and/or respiratory diseases |
EP2705838A1 (en) * | 2012-09-06 | 2014-03-12 | Xspray Microparticles Ab | Tiotropium preparations |
MX2021014782A (en) | 2012-10-22 | 2023-03-23 | Civitas Therapeutics Inc | Levodopa formulations for rapid relief of parkinson's disease. |
WO2014066206A1 (en) * | 2012-10-22 | 2014-05-01 | Civitas Therapeutics , Inc. | Reducing inter-patient variability of levodopa plasma concentrations |
WO2014066856A1 (en) | 2012-10-26 | 2014-05-01 | Mannkind Corporation | Inhalable influenza vaccine compositions and methods |
US11052202B2 (en) * | 2012-11-07 | 2021-07-06 | Chiesi Farmaceutici S.P.A. | Drug delivery device for the treatment of patients with respiratory diseases |
WO2014074797A1 (en) | 2012-11-09 | 2014-05-15 | Civitas Therapeutics, Inc. | Ultra low density pulmonary powders |
US9757395B2 (en) | 2012-12-20 | 2017-09-12 | Otitopic Inc. | Dry powder inhaler and methods of use |
US9757529B2 (en) | 2012-12-20 | 2017-09-12 | Otitopic Inc. | Dry powder inhaler and methods of use |
MX2015012529A (en) * | 2013-03-14 | 2016-07-05 | Novartis Ag | Deamorphization of spray-dried formulations via spray-blending. |
EP3587404B1 (en) | 2013-03-15 | 2022-07-13 | MannKind Corporation | Microcrystalline diketopiperazine compositions, methods for preparation and use thereof |
WO2014165303A1 (en) | 2013-04-01 | 2014-10-09 | Pulmatrix, Inc. | Tiotropium dry powders |
CN105473133A (en) | 2013-04-30 | 2016-04-06 | 欧缇托匹克公司 | Dry powder formulations and methods of use |
BR112016000937A8 (en) | 2013-07-18 | 2021-06-22 | Mannkind Corp | dry powder pharmaceutical formulations, method for making a dry powder formulation and use of a dry powder pharmaceutical formulation |
JP2016530930A (en) | 2013-08-05 | 2016-10-06 | マンカインド コーポレイション | Ventilation device and method |
CA2977083A1 (en) | 2014-02-20 | 2015-08-27 | Kambiz Yadidi | Dry powder formulations for inhalation |
WO2015148905A1 (en) | 2014-03-28 | 2015-10-01 | Mannkind Corporation | Use of ultrarapid acting insulin |
US20170296498A1 (en) | 2014-04-21 | 2017-10-19 | Civitas Therapeutics, Inc. | Rapid Relief of Motor Fluctuations in Parkinson's Disease |
US10561806B2 (en) | 2014-10-02 | 2020-02-18 | Mannkind Corporation | Mouthpiece cover for an inhaler |
MA40910A (en) | 2014-11-07 | 2017-09-12 | Civitas Therapeutics Inc | RAPAMYCIN POWDERS FOR PULMONARY ADMINISTRATION |
RU2750163C2 (en) | 2015-06-04 | 2021-06-22 | Крититек, Инк. | Taxan particles and their application |
JP2018524346A (en) | 2015-07-02 | 2018-08-30 | サイヴィタス セラピューティックス,インコーポレイテッド | Triptan powder for pulmonary delivery |
JP7077219B2 (en) * | 2015-09-09 | 2022-05-30 | ノバルティス アーゲー | Targeted delivery of spray-dried product to the lungs |
RU2737934C2 (en) | 2016-04-04 | 2020-12-07 | Крититек, Инк. | Methods of treating solid tumors |
AU2017261317A1 (en) | 2016-05-05 | 2018-12-13 | Liquidia Technologies, Inc. | Dry powder treprostinil for the treatment of pulmonary hypertension |
JP2020510002A (en) * | 2017-03-07 | 2020-04-02 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | Inhalable nicotine formulations and methods of making and using the same |
SG10201913649TA (en) | 2017-06-09 | 2020-03-30 | Crititech Inc | Treatment of epithelial cysts by intracystic injection of antineoplastic particles |
CA3063436A1 (en) | 2017-06-14 | 2018-12-20 | Crititech, Inc. | Methods for treating lung disorders |
CN111278436A (en) | 2017-10-03 | 2020-06-12 | 克里蒂泰克公司 | Local delivery of anti-tumor particles in combination with systemic delivery of immunotherapeutic agents for the treatment of cancer |
AU2020236689A1 (en) * | 2019-03-08 | 2021-09-02 | Chromaflo Technologies Europe B.V. | Solid colorant dispensing unit and tinting machine comprising the same |
CN113318097A (en) * | 2021-04-29 | 2021-08-31 | 珠海瑞思普利医药科技有限公司 | Powder inhalation for resisting idiopathic pulmonary fibrosis and preparation method thereof |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998031346A1 (en) * | 1997-01-16 | 1998-07-23 | Massachusetts Institute Of Technology | Preparation of particles for inhalation |
WO1999066903A2 (en) * | 1998-06-24 | 1999-12-29 | Advanced Inhalation Research, Inc. | Large porous particles emitted from an inhaler |
WO2000010541A1 (en) * | 1998-08-25 | 2000-03-02 | Advanced Inhalation Research, Inc. | Stable spray-dried protein formulations |
WO2000033811A2 (en) * | 1998-12-09 | 2000-06-15 | Vectura Limited | Improvements in or relating to powders |
WO2001013893A2 (en) * | 1999-08-25 | 2001-03-01 | Advanced Inhalation Research, Inc. | Use of simple amino acids to form porous particles |
Family Cites Families (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4069819A (en) | 1973-04-13 | 1978-01-24 | Societa Farmaceutici S.P.A. | Inhalation device |
EP0072046B1 (en) * | 1981-07-24 | 1986-01-15 | FISONS plc | Inhalation drugs, methods for their production and pharmaceutical formulations containing them |
US5260306A (en) | 1981-07-24 | 1993-11-09 | Fisons Plc | Inhalation pharmaceuticals |
IT1228459B (en) | 1989-02-23 | 1991-06-19 | Phidea S R L | INHALER WITH REGULAR AND COMPLETE EMPTYING OF THE CAPSULE. |
US5174988A (en) | 1989-07-27 | 1992-12-29 | Scientific Development & Research, Inc. | Phospholipid delivery system |
US5304125A (en) | 1990-10-05 | 1994-04-19 | The University Of North Carolina | Apparatus for administering solid particulate aerosols to the lungs |
US5993805A (en) | 1991-04-10 | 1999-11-30 | Quadrant Healthcare (Uk) Limited | Spray-dried microparticles and their use as therapeutic vehicles |
US6582728B1 (en) | 1992-07-08 | 2003-06-24 | Inhale Therapeutic Systems, Inc. | Spray drying of macromolecules to produce inhaleable dry powders |
SE9203743D0 (en) | 1992-12-11 | 1992-12-11 | Astra Ab | EFFICIENT USE |
TW402506B (en) | 1993-06-24 | 2000-08-21 | Astra Ab | Therapeutic preparation for inhalation |
US5830853A (en) | 1994-06-23 | 1998-11-03 | Astra Aktiebolag | Systemic administration of a therapeutic preparation |
US5506203C1 (en) | 1993-06-24 | 2001-02-06 | Astra Ab | Systemic administration of a therapeutic preparation |
GB9313650D0 (en) | 1993-07-01 | 1993-08-18 | Glaxo Group Ltd | Method and apparatus for the formation of particles |
GB9313642D0 (en) | 1993-07-01 | 1993-08-18 | Glaxo Group Ltd | Method and apparatus for the formation of particles |
US6051256A (en) | 1994-03-07 | 2000-04-18 | Inhale Therapeutic Systems | Dispersible macromolecule compositions and methods for their preparation and use |
MX9603936A (en) * | 1994-03-07 | 1997-05-31 | Inhale Therapeutic Syst | Methods and compositions for pulmonary delivery of insulin. |
GB9413202D0 (en) | 1994-06-30 | 1994-08-24 | Univ Bradford | Method and apparatus for the formation of particles |
US5641510A (en) | 1994-07-01 | 1997-06-24 | Genentech, Inc. | Method for treating capsules used for drug storage |
MX9702357A (en) | 1994-09-29 | 1997-06-28 | Andaris Ltd | Spray-dried microparticles as therapeutic vehicles. |
US6165463A (en) | 1997-10-16 | 2000-12-26 | Inhale Therapeutic Systems, Inc. | Dispersible antibody compositions and methods for their preparation and use |
WO1996032096A1 (en) | 1995-04-14 | 1996-10-17 | Inhale Therapeutic Systems | Powdered pharmaceutical formulations having improved dispersibility |
US6258341B1 (en) | 1995-04-14 | 2001-07-10 | Inhale Therapeutic Systems, Inc. | Stable glassy state powder formulations |
US6019968A (en) | 1995-04-14 | 2000-02-01 | Inhale Therapeutic Systems, Inc. | Dispersible antibody compositions and methods for their preparation and use |
USRE37053E1 (en) | 1996-05-24 | 2001-02-13 | Massachusetts Institute Of Technology | Particles incorporating surfactants for pulmonary drug delivery |
US5985309A (en) * | 1996-05-24 | 1999-11-16 | Massachusetts Institute Of Technology | Preparation of particles for inhalation |
US6503480B1 (en) | 1997-05-23 | 2003-01-07 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
US6254854B1 (en) | 1996-05-24 | 2001-07-03 | The Penn Research Foundation | Porous particles for deep lung delivery |
US6652837B1 (en) | 1996-05-24 | 2003-11-25 | Massachusetts Institute Of Technology | Preparation of novel particles for inhalation |
US5874064A (en) | 1996-05-24 | 1999-02-23 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
US5855913A (en) | 1997-01-16 | 1999-01-05 | Massachusetts Instite Of Technology | Particles incorporating surfactants for pulmonary drug delivery |
GB9621825D0 (en) | 1996-10-19 | 1996-12-11 | Andaris Ltd | Microparticles and their use as therapeutic vehicles |
JP2001517692A (en) | 1997-09-29 | 2001-10-09 | インヘール セラピューティック システムズ, インコーポレイテッド | Stabilized preparation for use in a nebulizer |
US6565885B1 (en) * | 1997-09-29 | 2003-05-20 | Inhale Therapeutic Systems, Inc. | Methods of spray drying pharmaceutical compositions |
US20010007853A1 (en) * | 1998-01-08 | 2001-07-12 | Dimarchi Richard Dennis | Method for administering monomeric insulin analogs |
US6284282B1 (en) * | 1998-04-29 | 2001-09-04 | Genentech, Inc. | Method of spray freeze drying proteins for pharmaceutical administration |
US6858199B1 (en) * | 2000-06-09 | 2005-02-22 | Advanced Inhalation Research, Inc. | High efficient delivery of a large therapeutic mass aerosol |
ATE313318T1 (en) * | 1999-10-29 | 2006-01-15 | Nektar Therapeutics | DRY POWDER COMPOSITIONS WITH IMPROVED DISPERSITY |
WO2001051030A1 (en) | 2000-01-10 | 2001-07-19 | Dura Pharmaceuticals, Inc. | Pharmaceutical formulation and method for pulmonary and oral delivery |
US6848197B2 (en) * | 2001-04-18 | 2005-02-01 | Advanced Inhalation Research, Inc. | Control of process humidity to produce large, porous particles |
-
2000
- 2000-06-09 US US09/591,307 patent/US6858199B1/en not_active Expired - Lifetime
-
2001
- 2001-06-08 DK DK01942072T patent/DK1296663T3/en active
- 2001-06-08 KR KR1020027016748A patent/KR100697479B1/en not_active IP Right Cessation
- 2001-06-08 MX MXPA02012023A patent/MXPA02012023A/en active IP Right Grant
- 2001-06-08 IL IL15328101A patent/IL153281A0/en unknown
- 2001-06-08 EP EP01942072A patent/EP1296663B1/en not_active Revoked
- 2001-06-08 RU RU2002134467/15A patent/RU2275900C2/en not_active IP Right Cessation
- 2001-06-08 SI SI200130734T patent/SI1296663T1/en unknown
- 2001-06-08 ES ES01942072T patent/ES2283417T3/en not_active Expired - Lifetime
- 2001-06-08 AU AU2001275368A patent/AU2001275368B2/en not_active Ceased
- 2001-06-08 PL PL36028701A patent/PL360287A1/en not_active Application Discontinuation
- 2001-06-08 US US09/878,146 patent/US7556798B2/en active Active
- 2001-06-08 CN CN01812533A patent/CN100589796C/en not_active Expired - Fee Related
- 2001-06-08 AT AT01942072T patent/ATE357222T1/en not_active IP Right Cessation
- 2001-06-08 EP EP07000049A patent/EP1767196A3/en not_active Withdrawn
- 2001-06-08 CA CA002412561A patent/CA2412561C/en not_active Expired - Fee Related
- 2001-06-08 WO PCT/US2001/018491 patent/WO2001095874A2/en active IP Right Grant
- 2001-06-08 NZ NZ523254A patent/NZ523254A/en unknown
- 2001-06-08 PT PT01942072T patent/PT1296663E/en unknown
- 2001-06-08 DE DE60127407T patent/DE60127407T2/en not_active Revoked
- 2001-06-08 JP JP2002510053A patent/JP2004503482A/en active Pending
- 2001-06-08 AU AU7536801A patent/AU7536801A/en active Pending
-
2002
- 2002-12-06 NO NO20025873A patent/NO20025873L/en not_active Application Discontinuation
-
2003
- 2003-05-12 HK HK03103294A patent/HK1051139A1/en not_active IP Right Cessation
- 2003-10-08 US US10/681,416 patent/US6921528B2/en not_active Expired - Lifetime
-
2008
- 2008-08-29 JP JP2008222436A patent/JP2009019047A/en active Pending
- 2008-10-17 US US12/253,449 patent/US20090068274A1/en not_active Abandoned
-
2011
- 2011-12-22 US US13/334,236 patent/US8628754B2/en not_active Expired - Fee Related
-
2013
- 2013-12-10 US US14/101,500 patent/US20140178476A1/en not_active Abandoned
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998031346A1 (en) * | 1997-01-16 | 1998-07-23 | Massachusetts Institute Of Technology | Preparation of particles for inhalation |
WO1999066903A2 (en) * | 1998-06-24 | 1999-12-29 | Advanced Inhalation Research, Inc. | Large porous particles emitted from an inhaler |
WO2000010541A1 (en) * | 1998-08-25 | 2000-03-02 | Advanced Inhalation Research, Inc. | Stable spray-dried protein formulations |
WO2000033811A2 (en) * | 1998-12-09 | 2000-06-15 | Vectura Limited | Improvements in or relating to powders |
WO2001013893A2 (en) * | 1999-08-25 | 2001-03-01 | Advanced Inhalation Research, Inc. | Use of simple amino acids to form porous particles |
Non-Patent Citations (3)
Title |
---|
ANDERSON S D ET AL: "A NEW METHOD FOR BRONCHIAL-PROVOCATION TESTING IN ASTHMATIC SUBJECTS USING A DRY POWDER OF MANNITOL", AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, AMERICAN LUNG ASSOCIATION, NEW YORK, NY, US, vol. 156, no. 3 PART 1, 1997, pages 758 - 765, XP002177457, ISSN: 1073-449X * |
ANDERSON S D ET AL: "The effect of inhaling a dry powder of sodium chloride on the airways of asthmatic subjects", EUROPEAN RESPIRATORY JOURNAL, MUNKSGAARD INTERNATIONAL PUBLISHERS, COPENHAGEN, DK, vol. 10, no. 11, November 1997 (1997-11-01), pages 2465 - 2473, XP002120358, ISSN: 0903-1936 * |
BEN-JEBRIA A ET AL: "LARGE POROUS PARTICLES FOR SUSTAINED PROTECTION FROM CARBACHOL- INDUCED BRONCHOCONSTRICTION IN GUINEA PIGS", PHARMACEUTICAL RESEARCH, NEW YORK, NY, US, vol. 16, no. 4, April 1999 (1999-04-01), pages 555 - 561, XP000856767, ISSN: 0724-8741 * |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9554993B2 (en) | 1997-09-29 | 2017-01-31 | Novartis Ag | Pulmonary delivery particles comprising an active agent |
US8877162B2 (en) | 2000-05-10 | 2014-11-04 | Novartis Ag | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery |
US9439862B2 (en) | 2000-05-10 | 2016-09-13 | Novartis Ag | Phospholipid-based powders for drug delivery |
US9421166B2 (en) | 2001-12-19 | 2016-08-23 | Novartis Ag | Pulmonary delivery of aminoglycoside |
US8992983B2 (en) | 2010-08-30 | 2015-03-31 | Pulmatrix, Inc. | Respirably dry powder comprising calcium lactate, sodium chloride and leucine |
US9061352B2 (en) | 2010-08-30 | 2015-06-23 | Pulmatrix, Inc. | Dry powder formulations and methods for treating pulmonary diseases |
US9233158B2 (en) | 2010-08-30 | 2016-01-12 | Pulmatrix, Inc. | Dry powder formulations and methods for treating pulmonary diseases |
US9433576B2 (en) | 2010-09-29 | 2016-09-06 | Pulmatrix, Inc. | Cationic dry powders |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2001095874A3 (en) | Highly efficient delivery of a large therapeutic mass aerosol | |
BG104720A (en) | Aerosolized active agent delivery | |
WO2004112702A3 (en) | Low dose pharmaceutical powders for inhalation | |
CA2304819A1 (en) | Perforated microparticles and methods of use | |
IL152306A0 (en) | Improvements in or relating to formulations for use in inhaler devices | |
JO2430B1 (en) | Pharmaceuticall Formulations for Dry Powder Inhalers in the form of Hard- Pellets | |
EA200100338A1 (en) | METHOD AND DEVICE FOR INTRODUCTION OF EXISTING SUBSTANCE IN THE FORM OF AEROSOL IN LUNG PATIENT | |
IS4179A (en) | Inhaled polypeptide formulation composition which also contains an enhancer compound | |
JO3102B1 (en) | Pharmaceutical formulations for dry powder inhalers comprising a low- dosage strength active ingredient | |
TNSN05047A1 (en) | Inhalation composition | |
MXPA05009629A (en) | Trospium containing compositions. | |
WO2004012653A3 (en) | Nebulizer formulations of dehydroepiandrosterone and methods of treating asthma or chronic obstructive pulmonary disease using compostions thereof | |
EP1599209A4 (en) | Inhalation composition | |
PL365736A1 (en) | Bimodal dry powder formulation for inhalation |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
WWE | Wipo information: entry into national phase |
Ref document number: 153281 Country of ref document: IL Ref document number: 2001942072 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Country of ref document: MX Ref document number: PA/a/2002/012023 |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2412561 Country of ref document: CA |
|
ENP | Entry into the national phase |
Ref document number: 2002 510053 Country of ref document: JP Kind code of ref document: A |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1020027016748 Country of ref document: KR Ref document number: 2001275368 Country of ref document: AU |
|
WWE | Wipo information: entry into national phase |
Ref document number: 523254 Country of ref document: NZ |
|
ENP | Entry into the national phase |
Ref document number: 2002134467 Country of ref document: RU Kind code of ref document: A Ref country code: RU Ref document number: RU A |
|
WWE | Wipo information: entry into national phase |
Ref document number: 018125336 Country of ref document: CN |
|
WWP | Wipo information: published in national office |
Ref document number: 2001942072 Country of ref document: EP |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
WWP | Wipo information: published in national office |
Ref document number: 1020027016748 Country of ref document: KR |
|
WWP | Wipo information: published in national office |
Ref document number: 523254 Country of ref document: NZ |
|
WWG | Wipo information: grant in national office |
Ref document number: 523254 Country of ref document: NZ |
|
WWG | Wipo information: grant in national office |
Ref document number: 2001275368 Country of ref document: AU |
|
WWG | Wipo information: grant in national office |
Ref document number: 2001942072 Country of ref document: EP |