WO2001098328A3 - Glycopeptide phosphonate derivatives - Google Patents

Glycopeptide phosphonate derivatives Download PDF

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Publication number
WO2001098328A3
WO2001098328A3 PCT/US2001/013998 US0113998W WO0198328A3 WO 2001098328 A3 WO2001098328 A3 WO 2001098328A3 US 0113998 W US0113998 W US 0113998W WO 0198328 A3 WO0198328 A3 WO 0198328A3
Authority
WO
WIPO (PCT)
Prior art keywords
derivatives
phosphonate derivatives
glycopeptide
glycopeptide phosphonate
disclosed
Prior art date
Application number
PCT/US2001/013998
Other languages
French (fr)
Other versions
WO2001098328A2 (en
Inventor
Michael R Leadbetter
Martin S Linsell
Original Assignee
Advanced Medicine Inc
Michael R Leadbetter
Martin S Linsell
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to UA2003010499A priority Critical patent/UA75083C2/en
Priority to BRPI0111222A priority patent/BRPI0111222B8/en
Priority to CA2411590A priority patent/CA2411590C/en
Priority to SK1852-2002A priority patent/SK287470B6/en
Priority to MXPA02012745A priority patent/MXPA02012745A/en
Priority to EA200300050A priority patent/EA005953B1/en
Priority to NZ522279A priority patent/NZ522279A/en
Priority to HU0301320A priority patent/HU229370B1/en
Priority to AU2001261107A priority patent/AU2001261107B2/en
Priority to AU6110701A priority patent/AU6110701A/en
Priority to EP01934967A priority patent/EP1292612B1/en
Priority to DE60122516T priority patent/DE60122516T2/en
Priority to JP2002504283A priority patent/JP3900491B2/en
Priority to IL152408A priority patent/IL152408A/en
Priority to SI200130642T priority patent/SI1292612T1/en
Application filed by Advanced Medicine Inc, Michael R Leadbetter, Martin S Linsell filed Critical Advanced Medicine Inc
Priority to PL359419A priority patent/PL207101B1/en
Publication of WO2001098328A2 publication Critical patent/WO2001098328A2/en
Publication of WO2001098328A3 publication Critical patent/WO2001098328A3/en
Priority to IS6600A priority patent/IS2303B/en
Priority to HR20020888A priority patent/HRP20020888B1/en
Priority to NO20025954A priority patent/NO330360B1/en
Priority to HK03104490.4A priority patent/HK1052191B/en
Priority to CY20061101256T priority patent/CY1105194T1/en
Priority to NO2011025C priority patent/NO2011025I1/en
Priority to LU91908C priority patent/LU91908I2/en
Priority to DE201112100062 priority patent/DE122011100062I1/en
Priority to CY2012006C priority patent/CY2012006I1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Nanotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Disclosed are derivatives of glycopeptides that are substituted with one or more substituents each comprising one or more phosphono groups; and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.
PCT/US2001/013998 2000-06-22 2001-05-01 Glycopeptide phosphonate derivatives WO2001098328A2 (en)

Priority Applications (25)

Application Number Priority Date Filing Date Title
UA2003010499A UA75083C2 (en) 2000-06-22 2001-01-05 Derivatives of glycopeptidephosphonates
SI200130642T SI1292612T1 (en) 2000-06-22 2001-05-01 Glycopeptide phosphonate derivatives
IL152408A IL152408A (en) 2000-06-22 2001-05-01 Glycopeptide phosphonate derivatives
MXPA02012745A MXPA02012745A (en) 2000-06-22 2001-05-01 Glycopeptide phosphonate derivatives.
EA200300050A EA005953B1 (en) 2000-06-22 2001-05-01 Glycopeptidephosphonate derivatives
NZ522279A NZ522279A (en) 2000-06-22 2001-05-01 Glycopeptide phosphonate derivatives
HU0301320A HU229370B1 (en) 2000-06-22 2001-05-01 Glycopeptide phosphonate derivatives
AU2001261107A AU2001261107B2 (en) 2000-06-22 2001-05-01 Glycopeptide phosphonate derivatives
AU6110701A AU6110701A (en) 2000-06-22 2001-05-01 Glycopeptide phosphonate derivatives
CA2411590A CA2411590C (en) 2000-06-22 2001-05-01 Glycopeptide phosphonate derivatives
DE60122516T DE60122516T2 (en) 2000-06-22 2001-05-01 PHOSPHONATE DERIVATIVES OF A GLYCOPEPTIDE
JP2002504283A JP3900491B2 (en) 2000-06-22 2001-05-01 Glycopeptide phosphonate derivative
SK1852-2002A SK287470B6 (en) 2000-06-22 2001-05-01 Glycopeptide phosphonate derivatives
BRPI0111222A BRPI0111222B8 (en) 2000-06-22 2001-05-01 phosphonate derivatives of glycopeptide.
EP01934967A EP1292612B1 (en) 2000-06-22 2001-05-01 Glycopeptide phosphonate derivatives
PL359419A PL207101B1 (en) 2000-06-22 2001-05-01 Glycopeptide phosphonate derivatives
IS6600A IS2303B (en) 2000-06-22 2002-10-29 Glycopeptide phosphonate derivatives
HR20020888A HRP20020888B1 (en) 2000-06-22 2002-11-11 Glycopeptide phosphonate derivatives
NO20025954A NO330360B1 (en) 2000-06-22 2002-12-11 Glycopeptide phosphonate derivatives, process for their preparation, pharmaceutical preparation and use of the glycopeptide.
HK03104490.4A HK1052191B (en) 2000-06-22 2003-06-23 Glycopeptide phosphonate derivatives
CY20061101256T CY1105194T1 (en) 2000-06-22 2006-09-04 PHOSPHONIC DERIVATIVES OF GLYCOPEPTIDES
NO2011025C NO2011025I1 (en) 2000-06-22 2011-11-18 Telavancin, or a pharmaceutically acceptable salt thereof, including including telavancin hydrochloride
LU91908C LU91908I2 (en) 2000-06-22 2011-11-30 Telavancine, or a pharmaceutically acceptable salt thereof, including telavancine hydrochloride (VIBATIV®)
DE201112100062 DE122011100062I1 (en) 2000-06-22 2011-11-30 Phosphonate derivatives of a glycopeptide.
CY2012006C CY2012006I1 (en) 2000-06-22 2012-02-02 PHOSPHONIC DERIVATIVES OF GLYCOPEPTIDES

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21341000P 2000-06-22 2000-06-22
US60/213,410 2000-06-22

Publications (2)

Publication Number Publication Date
WO2001098328A2 WO2001098328A2 (en) 2001-12-27
WO2001098328A3 true WO2001098328A3 (en) 2002-04-11

Family

ID=22795013

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/013998 WO2001098328A2 (en) 2000-06-22 2001-05-01 Glycopeptide phosphonate derivatives

Country Status (36)

Country Link
US (10) US6635618B2 (en)
EP (1) EP1292612B1 (en)
JP (2) JP3900491B2 (en)
KR (1) KR100768488B1 (en)
CN (1) CN100469788C (en)
AR (1) AR035333A1 (en)
AT (1) ATE337334T1 (en)
AU (2) AU2001261107B2 (en)
BR (1) BRPI0111222B8 (en)
CA (2) CA2411590C (en)
CY (2) CY1105194T1 (en)
CZ (1) CZ303672B6 (en)
DE (2) DE60122516T2 (en)
DK (1) DK1292612T3 (en)
EA (1) EA005953B1 (en)
EG (1) EG26726A (en)
ES (1) ES2271012T3 (en)
HK (1) HK1052191B (en)
HR (1) HRP20020888B1 (en)
HU (2) HU229370B1 (en)
IL (1) IL152408A (en)
IS (1) IS2303B (en)
LU (1) LU91908I2 (en)
MX (1) MXPA02012745A (en)
MY (1) MY127081A (en)
NO (2) NO330360B1 (en)
NZ (1) NZ522279A (en)
PL (1) PL207101B1 (en)
PT (1) PT1292612E (en)
RS (1) RS50499B (en)
SI (1) SI1292612T1 (en)
SK (1) SK287470B6 (en)
TW (1) TWI305209B (en)
UA (1) UA75083C2 (en)
WO (1) WO2001098328A2 (en)
ZA (1) ZA200209419B (en)

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US6872804B2 (en) 2000-06-22 2005-03-29 Theravance, Inc. Glycopeptide disulfide and thioester derivatives
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