WO2002014403A3 - Acid end group poly(d,l-lactide-co-glycolide) copolymers with high glycolide content - Google Patents

Acid end group poly(d,l-lactide-co-glycolide) copolymers with high glycolide content Download PDF

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Publication number
WO2002014403A3
WO2002014403A3 PCT/US2001/024423 US0124423W WO0214403A3 WO 2002014403 A3 WO2002014403 A3 WO 2002014403A3 US 0124423 W US0124423 W US 0124423W WO 0214403 A3 WO0214403 A3 WO 0214403A3
Authority
WO
WIPO (PCT)
Prior art keywords
glycolide
lactide
copolymers
end group
acid end
Prior art date
Application number
PCT/US2001/024423
Other languages
French (fr)
Other versions
WO2002014403A2 (en
Inventor
Chiem V Pham
Original Assignee
Alkermes Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alkermes Inc filed Critical Alkermes Inc
Priority to AU2001281045A priority Critical patent/AU2001281045A1/en
Publication of WO2002014403A2 publication Critical patent/WO2002014403A2/en
Publication of WO2002014403A3 publication Critical patent/WO2002014403A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/78—Preparation processes
    • C08G63/82—Preparation processes characterised by the catalyst used
    • C08G63/823—Preparation processes characterised by the catalyst used for the preparation of polylactones or polylactides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH] (Somatotropin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • C08G63/08—Lactones or lactides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y10T428/2985—Solid-walled microcapsule from synthetic polymer

Abstract

Copolymers of lactide and glycolide with high glycolide content. the average glycolate block length is less then about 3, allows the copolymer to be soluble in slightly polar solvents such as methylene chloride.
PCT/US2001/024423 2000-08-10 2001-08-02 Acid end group poly(d,l-lactide-co-glycolide) copolymers with high glycolide content WO2002014403A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001281045A AU2001281045A1 (en) 2000-08-10 2001-08-02 Acid end group poly(d,l-lactide-co-glycolide) copolymers with high glycolide content

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/635,677 2000-08-10
US09/635,677 US6362308B1 (en) 2000-08-10 2000-08-10 Acid end group poly(d,l-lactide-co-glycolide) copolymers high glycolide content

Publications (2)

Publication Number Publication Date
WO2002014403A2 WO2002014403A2 (en) 2002-02-21
WO2002014403A3 true WO2002014403A3 (en) 2002-08-01

Family

ID=24548683

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/024423 WO2002014403A2 (en) 2000-08-10 2001-08-02 Acid end group poly(d,l-lactide-co-glycolide) copolymers with high glycolide content

Country Status (3)

Country Link
US (3) US6362308B1 (en)
AU (1) AU2001281045A1 (en)
WO (1) WO2002014403A2 (en)

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US6362308B1 (en) * 2000-08-10 2002-03-26 Alkermes Controlled Therapeutics Inc. Ii Acid end group poly(d,l-lactide-co-glycolide) copolymers high glycolide content
US7309498B2 (en) * 2001-10-10 2007-12-18 Belenkaya Bronislava G Biodegradable absorbents and methods of preparation
KR20050012221A (en) * 2001-11-12 2005-01-31 오노 야꾸힝 고교 가부시키가이샤 Persistent filmy preparation for topical administration containing prostaglandin derivative
US20070196415A1 (en) * 2002-11-14 2007-08-23 Guohua Chen Depot compositions with multiple drug release rate controls and uses thereof
KR20040058101A (en) * 2001-11-14 2004-07-03 알자 코포레이션 Catheter injectable depot compositions and uses thereof
US6528044B1 (en) * 2001-12-27 2003-03-04 Avon Products, Inc. Pigmented cosmetic compositions
MY135206A (en) * 2002-01-11 2008-02-29 Daicel Chem Process of continuously producing polyester-based polymer
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
US7163545B2 (en) * 2002-07-29 2007-01-16 Mayo Foundation For Medical Education And Research Spinal cord surgical implant
WO2004011054A2 (en) * 2002-07-31 2004-02-05 Alza Corporation Injectable multimodal polymer depot compositions and uses thereof
DE60226282T2 (en) * 2002-07-31 2009-09-17 Alza Corp., Mountain View INJECTABLE DEPOT COMPOSITIONS AND THEIR USE
EP1440992A1 (en) * 2003-01-21 2004-07-28 Société de Conseils de Recherches et d'Applications Scientifiques ( S.C.R.A.S.) Catalyst composition for (co)polymerisation of lactide and glycolide
US20060142234A1 (en) * 2004-12-23 2006-06-29 Guohua Chen Injectable non-aqueous suspension
EP1686807A1 (en) * 2005-01-27 2006-08-02 Nagra France Sarl Method of load balancing of a management center transmitting informations to a big number of user-units
JP2007023189A (en) * 2005-07-19 2007-02-01 Univ Kinki Compatibilizing agent and resin composition
US7794495B2 (en) * 2006-07-17 2010-09-14 Advanced Cardiovascular Systems, Inc. Controlled degradation of stents
DE102007036101A1 (en) 2007-08-01 2009-02-05 Boehringer Ingelheim Pharma Gmbh & Co. Kg New glycolide-rich copolymers
JP5453693B2 (en) * 2007-10-29 2014-03-26 ディーエスエム アイピー アセッツ ビー．ブイ． Composition containing resveratrol and pectin
US8652506B2 (en) 2008-06-05 2014-02-18 Boston Scientific Scimed, Inc. Bio-degradable block co-polymers for controlled release
WO2010085607A1 (en) * 2009-01-23 2010-07-29 Surmodics Pharmaceuticals, Inc. Continuous double emulsion process for making microparticles
EP3079668A1 (en) 2013-12-09 2016-10-19 Durect Corporation Pharmaceutically active agent complexes, polymer complexes, and compositions and methods involving the same
ES2546566B2 (en) * 2015-07-23 2016-09-14 Universidade De Santiago De Compostela System for the administration of biologically active substances prepared by foaming techniques using compressed gases or supercritical fluids
KR20220140711A (en) 2020-01-13 2022-10-18 듀렉트 코퍼레이션 Reduced Impurity Sustained Release Drug Delivery Systems and Related Methods

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Also Published As

Publication number Publication date
US6703477B2 (en) 2004-03-09
WO2002014403A2 (en) 2002-02-21
US7074883B2 (en) 2006-07-11
AU2001281045A1 (en) 2002-02-25
US20040108609A1 (en) 2004-06-10
US20020086971A1 (en) 2002-07-04
US6362308B1 (en) 2002-03-26

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