WO2002015877A8 - Methods and compositions for targeted delivery - Google Patents

Methods and compositions for targeted delivery

Info

Publication number
WO2002015877A8
WO2002015877A8 PCT/US2001/026094 US0126094W WO0215877A8 WO 2002015877 A8 WO2002015877 A8 WO 2002015877A8 US 0126094 W US0126094 W US 0126094W WO 0215877 A8 WO0215877 A8 WO 0215877A8
Authority
WO
WIPO (PCT)
Prior art keywords
microparticles
composition
water
biologically active
soluble polymer
Prior art date
Application number
PCT/US2001/026094
Other languages
French (fr)
Other versions
WO2002015877A2 (en
WO2002015877A3 (en
Inventor
Mark A Tracy
David S Scher
Original Assignee
Alkermes Inc
Mark A Tracy
David S Scher
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alkermes Inc, Mark A Tracy, David S Scher filed Critical Alkermes Inc
Priority to AU2001285143A priority Critical patent/AU2001285143A1/en
Publication of WO2002015877A2 publication Critical patent/WO2002015877A2/en
Publication of WO2002015877A8 publication Critical patent/WO2002015877A8/en
Publication of WO2002015877A3 publication Critical patent/WO2002015877A3/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1641Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647Polyesters, e.g. poly(lactide-co-glycolide)
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The present invention relates to a sustained release composition for the targeted delivery of biologically active agents to specific tissues and cells. The composition comprises microparticles containing a biocompatible polymer, a water-soluble polymer and a biologically active agent. In one embodiment, the biologically active agent is an antigent or an immunomodulator. In another embodiment, the biologically is a labile agent. The microparticles have a number median diameter of greater than 20 microns upon administration. The water-soluble polymer is present in the sustained released composition in at least about 20 % of the dry weight of the microparticle. The sustained release composition provides for the dissolution of the water-soluble polymer of the composition upon hydration, at a much greater rate than the degradation of the biocompatible polymer. This variance is solubility generates pseudo-microparticles which have a number median diameter which is substantially smaller than the size of the administered microparticles. The pseudo-microparticles can be engulfed by antigen presenting cells of the immune system, or absorbed by the Peyer's patches in the gut.
PCT/US2001/026094 2000-08-23 2001-08-21 Methods and compositions for targeted delivery WO2002015877A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001285143A AU2001285143A1 (en) 2000-08-23 2001-08-21 Methods and compositions for targeted delivery

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/644,631 US6565888B1 (en) 2000-08-23 2000-08-23 Methods and compositions for the targeted delivery of biologically active agents
US09/644,631 2000-08-23

Publications (3)

Publication Number Publication Date
WO2002015877A2 WO2002015877A2 (en) 2002-02-28
WO2002015877A8 true WO2002015877A8 (en) 2002-11-21
WO2002015877A3 WO2002015877A3 (en) 2003-02-27

Family

ID=24585726

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/026094 WO2002015877A2 (en) 2000-08-23 2001-08-21 Methods and compositions for targeted delivery

Country Status (3)

Country Link
US (2) US6565888B1 (en)
AU (1) AU2001285143A1 (en)
WO (1) WO2002015877A2 (en)

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CA2581775A1 (en) * 2004-09-27 2006-04-06 Sigmoid Biotechnologies Limited Dihydropyrimidine microcapsule - formulations
US20060115485A1 (en) * 2004-10-29 2006-06-01 Medimmune, Inc. Methods of preventing and treating RSV infections and related conditions
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CA2613619A1 (en) 2005-07-07 2007-01-18 Fulcrum Sp Ltd. Sp1 polypeptides, modified sp1 polypeptides and uses thereof
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JP2010511427A (en) * 2006-12-01 2010-04-15 ウェイク・フォレスト・ユニヴァーシティ・ヘルス・サイエンシズ Medical device containing collagen inhibitor
GB2446780A (en) * 2007-02-22 2008-08-27 Glide Pharmaceutical Technolog An elongate parenteral injection body having an injection point of angle 10 to 40 degrees.
WO2008121349A1 (en) * 2007-03-29 2008-10-09 University Of Delaware Tag and target delivery system
US10493040B2 (en) 2007-04-09 2019-12-03 Wake Forest University Health Sciences Oxygen-generating compositions for enhancing cell and tissue survival in vivo
EP1997830A1 (en) 2007-06-01 2008-12-03 AIMM Therapeutics B.V. RSV specific binding molecules and means for producing them
US20090061009A1 (en) * 2007-08-29 2009-03-05 Joseph Schwarz Composition and Method of Treatment of Bacterial Infections
GB0721081D0 (en) * 2007-10-26 2007-12-05 Metcalfe Susan M Immuno-modulatory composition
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US9107815B2 (en) 2008-02-22 2015-08-18 Allergan, Inc. Sustained release poloxamer containing pharmaceutical compositions
JP2012515790A (en) * 2009-01-23 2012-07-12 サーモディクス ファーマシューティカルズ, インコーポレイテッド Continuous double emulsion process for fine particle production
JP5640079B2 (en) 2009-05-18 2014-12-10 シグモイド・ファーマ・リミテッドSigmoid Pharma Limited Oil droplet-containing composition
CN107582526A (en) * 2009-08-12 2018-01-16 希格默伊德药业有限公司 Immune regulation composite comprising polymer substrate and oil phase
US8568726B2 (en) 2009-10-06 2013-10-29 Medimmune Limited RSV specific binding molecule
GB201212010D0 (en) 2012-07-05 2012-08-22 Sigmoid Pharma Ltd Formulations
WO2014031883A1 (en) 2012-08-23 2014-02-27 Susan Marie Metcalfe Neurotherapeutic nanoparticle compositions and devices
GB201319791D0 (en) 2013-11-08 2013-12-25 Sigmoid Pharma Ltd Formulations
WO2015088990A1 (en) 2013-12-09 2015-06-18 Durect Corporation Pharmaceutically active agent complexes, polymer complexes, and compositions and methods involving the same
CA2966801A1 (en) 2014-11-07 2016-05-12 Sigmoid Pharma Limited Compositions comprising cyclosporin
US11260027B2 (en) 2015-07-29 2022-03-01 Musc Foundation For Research Development Donor organ pre-treatment formulation
US10953103B2 (en) 2015-11-06 2021-03-23 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V Composition comprising a biocompatible and biodegradable polymer, nanocarriers and a drug and methods of making and using the same
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Also Published As

Publication number Publication date
US7097857B2 (en) 2006-08-29
WO2002015877A2 (en) 2002-02-28
US20060141041A1 (en) 2006-06-29
AU2001285143A1 (en) 2002-03-04
WO2002015877A3 (en) 2003-02-27
US6565888B1 (en) 2003-05-20

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