WO2002016384A3 - Apparatus and methods for the automated synthesis of oligosaccharides - Google Patents
Apparatus and methods for the automated synthesis of oligosaccharides Download PDFInfo
- Publication number
- WO2002016384A3 WO2002016384A3 PCT/US2001/025859 US0125859W WO0216384A3 WO 2002016384 A3 WO2002016384 A3 WO 2002016384A3 US 0125859 W US0125859 W US 0125859W WO 0216384 A3 WO0216384 A3 WO 0216384A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- oligosaccharides
- methods
- automated synthesis
- present
- solid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/12—Libraries containing saccharides or polysaccharides, or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
- C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00281—Individual reactor vessels
- B01J2219/00286—Reactor vessels with top and bottom openings
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00414—Means for dispensing and evacuation of reagents using suction
- B01J2219/00416—Vacuum
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00418—Means for dispensing and evacuation of reagents using pressure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00423—Means for dispensing and evacuation of reagents using filtration, e.g. through porous frits
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00452—Means for the recovery of reactants or products
- B01J2219/00454—Means for the recovery of reactants or products by chemical cleavage from the solid support
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00495—Means for heating or cooling the reaction vessels
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/005—Beads
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/0054—Means for coding or tagging the apparatus or the reagents
- B01J2219/00572—Chemical means
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/0054—Means for coding or tagging the apparatus or the reagents
- B01J2219/00572—Chemical means
- B01J2219/00576—Chemical means fluorophore
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/0054—Means for coding or tagging the apparatus or the reagents
- B01J2219/00572—Chemical means
- B01J2219/00578—Chemical means electrophoric
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/0059—Sequential processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00596—Solid-phase processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/0068—Means for controlling the apparatus of the process
- B01J2219/00686—Automatic
- B01J2219/00689—Automatic using computers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/00731—Saccharides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/11—Compounds covalently bound to a solid support
Abstract
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002420183A CA2420183C (en) | 2000-08-18 | 2001-08-17 | Apparatus and methods for the automated synthesis of oligosaccharides |
DE60110094T DE60110094T2 (en) | 2000-08-18 | 2001-08-17 | DEVICE AND METHOD FOR THE AUTOMATED SYNTHESIS OF OLIGOSACCHARIDES |
AU8653901A AU8653901A (en) | 2000-08-18 | 2001-08-17 | Apparatus and methods for the automated synthesis of oligosaccharides |
EP01965993A EP1315559B1 (en) | 2000-08-18 | 2001-08-17 | Apparatus and methods for the automated synthesis of oligosaccharides |
AU2001286539A AU2001286539B2 (en) | 2000-08-18 | 2001-08-17 | Apparatus and methods for the automated synthesis of oligosaccharides |
JP2002521481A JP2004507467A (en) | 2000-08-18 | 2001-08-17 | Apparatus and method for automated synthesis of oligosaccharides |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22616900P | 2000-08-18 | 2000-08-18 | |
US60/226,169 | 2000-08-18 | ||
US25423300P | 2000-12-08 | 2000-12-08 | |
US60/254,233 | 2000-12-08 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2002016384A2 WO2002016384A2 (en) | 2002-02-28 |
WO2002016384A3 true WO2002016384A3 (en) | 2002-07-18 |
Family
ID=26920272
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/025859 WO2002016384A2 (en) | 2000-08-18 | 2001-08-17 | Apparatus and methods for the automated synthesis of oligosaccharides |
Country Status (8)
Country | Link |
---|---|
US (2) | US7160517B2 (en) |
EP (1) | EP1315559B1 (en) |
JP (1) | JP2004507467A (en) |
AT (1) | ATE320847T1 (en) |
AU (2) | AU2001286539B2 (en) |
CA (1) | CA2420183C (en) |
DE (1) | DE60110094T2 (en) |
WO (1) | WO2002016384A2 (en) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7723296B2 (en) * | 2001-01-18 | 2010-05-25 | Genzyme Corporation | Methods for introducing mannose-6-phosphate and other oligosaccharides onto glycoproteins and its application thereof |
JP4006385B2 (en) * | 2002-11-20 | 2007-11-14 | 株式会社日立ハイテクノロジーズ | Sugar chain synthesizer |
WO2005000861A1 (en) * | 2003-06-30 | 2005-01-06 | Mitsubishi Chemical Corporation | Method of synthesizing sugar chain |
CN100432085C (en) * | 2003-12-22 | 2008-11-12 | 叶新山 | Iterative oligosaccharide synthesis |
JP4252922B2 (en) * | 2004-03-31 | 2009-04-08 | 株式会社日立ハイテクノロジーズ | Sugar chain synthesizer |
JP2006151948A (en) * | 2004-11-04 | 2006-06-15 | Institute Of Physical & Chemical Research | Method for synthesizing sugar chain and automatic sugar chain synthesis apparatus |
US10059736B2 (en) * | 2005-03-15 | 2018-08-28 | Mcgill University | Ionic liquid supported synthesis |
US8420607B2 (en) * | 2006-06-30 | 2013-04-16 | University Of Georgia Research Foundation, Inc. | Anthrax carbohydrates, synthesis and uses thereof |
WO2008115198A2 (en) | 2006-06-30 | 2008-09-25 | University Of Georgia Research Foundation, Inc. | Anthrax carbohydrates,synthesis and uses thereof |
EP2069558B1 (en) | 2006-10-02 | 2013-05-01 | Sea Lane Biotechnologies,llc. | Design and construction of diverse synthetic peptide and polypeptide libraries |
SI2457919T1 (en) | 2007-01-18 | 2019-10-30 | Genzyme Corp | Oligosaccharides comprising an aminooxy group and conjugates thereof |
US20100159604A1 (en) * | 2007-06-22 | 2010-06-24 | Iowa State University Research Foundation, Inc. | Automated solution-phase iterative synthesis |
US8211370B2 (en) * | 2007-12-07 | 2012-07-03 | Thomas Downing | Polymer synthesizer |
EP2145895B1 (en) * | 2008-07-08 | 2013-10-30 | Commissariat à l'Énergie Atomique et aux Énergies Alternatives | Process for the manufacturing of glycochips |
US20110313148A1 (en) * | 2008-07-23 | 2011-12-22 | William Christ | Automated oligosaccharide synthesizer |
LT2889043T (en) | 2008-12-16 | 2019-07-10 | Genzyme Corporation | Synthetic intermediates for preparing oligosaccharide-protein conjugates |
WO2011102914A2 (en) * | 2010-02-22 | 2011-08-25 | Oligoco | Automated polymer-synthesis system |
US8580201B2 (en) | 2010-02-22 | 2013-11-12 | Oligoco, Inc. | Wicking-based reagent-solution draining in an automated system |
KR101736487B1 (en) | 2010-06-04 | 2017-05-17 | 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) | Novel immunoadjuvant compounds and uses thereof |
CN105461767B (en) * | 2014-08-07 | 2019-03-12 | 富力 | A kind of chemical synthesis process of forsythin |
WO2021089623A1 (en) * | 2019-11-04 | 2021-05-14 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Synthesizer for oligo- and polysaccharides on solid phase |
EP3815778A1 (en) * | 2019-11-04 | 2021-05-05 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Device for rapid automated synthesis of oligo- and polysaccharides |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4598049A (en) * | 1983-08-31 | 1986-07-01 | Systec Inc. | General purpose gene synthesizer |
US4610847A (en) * | 1980-09-23 | 1986-09-09 | California Institute Of Technology | Conversion flask for sequential performance apparatus |
EP0355266A2 (en) * | 1988-04-29 | 1990-02-28 | Millipore Corporation | Apparatus for performing repetitive chemical reactions |
US5462748A (en) * | 1991-11-05 | 1995-10-31 | Applied Biosystems, Inc. | Biopolymer synthesis apparatus and method |
US5466608A (en) * | 1991-03-06 | 1995-11-14 | Rhon-Poulenc Rorer S.A. | Process and apparatus for heterogeneous phase synthesis of macromolecules such as peptides, polynucloetides or oligosaccharides |
WO1998057181A1 (en) * | 1997-06-10 | 1998-12-17 | Pharmacopeia, Inc. | Methods and apparatus for universal fluid exchange |
WO2000020428A2 (en) * | 1998-10-06 | 2000-04-13 | Massachusetts Institute Of Technology | Synthesis of oligosaccharides, reagents and methods related thereto |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5256549A (en) * | 1986-03-28 | 1993-10-26 | Chiron Corporation | Purification of synthetic oligomers |
AU673845B2 (en) * | 1992-06-01 | 1996-11-28 | Biomembrane Institute, The | Sequential removal of monosaccharides from the reducing end of oligosaccharides and uses thereof |
DE69302692T2 (en) * | 1992-07-06 | 1996-10-02 | Beckman Instruments Inc | Liquid supply system with reusable valve |
US5639866A (en) * | 1993-02-23 | 1997-06-17 | Princeton University | Single-step formation of multiple glycosidic linkages |
AUPO190596A0 (en) * | 1996-08-26 | 1996-09-19 | Alchemia Pty Ltd | Oligosaccharide synthesis |
-
2001
- 2001-08-17 DE DE60110094T patent/DE60110094T2/en not_active Expired - Lifetime
- 2001-08-17 EP EP01965993A patent/EP1315559B1/en not_active Expired - Lifetime
- 2001-08-17 AU AU2001286539A patent/AU2001286539B2/en not_active Expired
- 2001-08-17 US US09/932,277 patent/US7160517B2/en not_active Expired - Lifetime
- 2001-08-17 CA CA002420183A patent/CA2420183C/en not_active Expired - Lifetime
- 2001-08-17 AU AU8653901A patent/AU8653901A/en active Pending
- 2001-08-17 WO PCT/US2001/025859 patent/WO2002016384A2/en active IP Right Grant
- 2001-08-17 AT AT01965993T patent/ATE320847T1/en not_active IP Right Cessation
- 2001-08-17 JP JP2002521481A patent/JP2004507467A/en active Pending
-
2007
- 2007-01-09 US US11/651,398 patent/US20070265441A1/en not_active Abandoned
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4610847A (en) * | 1980-09-23 | 1986-09-09 | California Institute Of Technology | Conversion flask for sequential performance apparatus |
US4598049A (en) * | 1983-08-31 | 1986-07-01 | Systec Inc. | General purpose gene synthesizer |
EP0355266A2 (en) * | 1988-04-29 | 1990-02-28 | Millipore Corporation | Apparatus for performing repetitive chemical reactions |
US5466608A (en) * | 1991-03-06 | 1995-11-14 | Rhon-Poulenc Rorer S.A. | Process and apparatus for heterogeneous phase synthesis of macromolecules such as peptides, polynucloetides or oligosaccharides |
US5462748A (en) * | 1991-11-05 | 1995-10-31 | Applied Biosystems, Inc. | Biopolymer synthesis apparatus and method |
WO1998057181A1 (en) * | 1997-06-10 | 1998-12-17 | Pharmacopeia, Inc. | Methods and apparatus for universal fluid exchange |
WO2000020428A2 (en) * | 1998-10-06 | 2000-04-13 | Massachusetts Institute Of Technology | Synthesis of oligosaccharides, reagents and methods related thereto |
Non-Patent Citations (3)
Title |
---|
HELEN M. I. OSBORN & TARIQ H. KHAN: "Recent Developments in Polymer Supported Syntheses of Oligosaccharides and Glycopeptides", TETRAHEDRON, vol. 55, no. 7, 12 February 1999 (1999-02-12), AMSTERDAM, NL, pages 1807 - 1850, XP004155328, ISSN: 0040-4020 * |
PHAEDRIA M. ST. HILAIRE & MORTEN MELDAL: "GLYCOPEPTIDE AND OLIGOSACCHARIDE LIBRARIES", ANGEWANDTE CHEMIE. INTERNATIONAL EDITION, vol. 39, no. 7, 3 April 2000 (2000-04-03), WEINHEIM, DE, pages 1163 - 1179, XP000920003, ISSN: 0570-0833 * |
ZHI-GUANG WANG & OLE HINDSGAUL: "COMBINATORIAL CARBOHYDRATE CHEMISTRY", GLYCOIMMUNOLOGY 2, 1999, NEW YORK. NY, US, pages 219 - 236, XP002922444 * |
Also Published As
Publication number | Publication date |
---|---|
JP2004507467A (en) | 2004-03-11 |
AU2001286539B2 (en) | 2007-01-04 |
US20070265441A1 (en) | 2007-11-15 |
EP1315559B1 (en) | 2006-03-22 |
AU8653901A (en) | 2002-03-04 |
WO2002016384A2 (en) | 2002-02-28 |
US20020085964A1 (en) | 2002-07-04 |
DE60110094T2 (en) | 2009-10-01 |
US7160517B2 (en) | 2007-01-09 |
DE60110094D1 (en) | 2005-05-19 |
ATE320847T1 (en) | 2006-04-15 |
EP1315559A2 (en) | 2003-06-04 |
CA2420183C (en) | 2009-11-24 |
CA2420183A1 (en) | 2002-02-28 |
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