WO2002018643A3 - Nanoparticles having oligonucleotides attached thereto and uses therefor - Google Patents
Nanoparticles having oligonucleotides attached thereto and uses therefor Download PDFInfo
- Publication number
- WO2002018643A3 WO2002018643A3 PCT/US2001/025237 US0125237W WO0218643A3 WO 2002018643 A3 WO2002018643 A3 WO 2002018643A3 US 0125237 W US0125237 W US 0125237W WO 0218643 A3 WO0218643 A3 WO 0218643A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- nanoparticles
- methods
- nucleic acid
- provides
- oligonucleotides
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6825—Nucleic acid detection involving sensors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
- C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Nanotechnology (AREA)
- Crystallography & Structural Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Composite Materials (AREA)
- Materials Engineering (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Abstract
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002418502A CA2418502A1 (en) | 2000-08-11 | 2001-08-10 | Nanoparticles having oligonucleotides attached thereto and uses therefor |
AU2001281248A AU2001281248A1 (en) | 2000-08-11 | 2001-08-10 | Nanoparticles having oligonucleotides attached thereto and uses therefor |
EP01959723A EP1362121A2 (en) | 2000-08-11 | 2001-08-10 | Nanoparticles having oligonucleotides attached thereto and uses therefor |
JP2002522548A JP2004525607A (en) | 2000-08-11 | 2001-08-10 | Oligonucleotide-attached nanoparticles and methods of use |
AU2006200274A AU2006200274A1 (en) | 2000-08-11 | 2006-01-23 | Nanoparticles Having Oligonucleotides Attached thereto and uses therefor |
Applications Claiming Priority (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22463100P | 2000-08-11 | 2000-08-11 | |
US60/224,631 | 2000-08-11 | ||
US25439200P | 2000-12-08 | 2000-12-08 | |
US60/254,392 | 2000-12-08 | ||
US25523500P | 2000-12-11 | 2000-12-11 | |
US60/255,235 | 2000-12-11 | ||
US09/760,500 US6767702B2 (en) | 1996-07-29 | 2001-01-12 | Nanoparticles having oligonucleotides attached thereto and uses therefor |
US09/760,500 | 2001-01-12 | ||
US09/820,279 | 2001-03-28 | ||
US09/820,279 US6750016B2 (en) | 1996-07-29 | 2001-03-28 | Nanoparticles having oligonucleotides attached thereto and uses therefor |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2002018643A2 WO2002018643A2 (en) | 2002-03-07 |
WO2002018643A3 true WO2002018643A3 (en) | 2003-09-04 |
WO2002018643A9 WO2002018643A9 (en) | 2003-11-06 |
Family
ID=27539880
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/025237 WO2002018643A2 (en) | 2000-08-11 | 2001-08-10 | Nanoparticles having oligonucleotides attached thereto and uses therefor |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1362121A2 (en) |
JP (1) | JP2004525607A (en) |
AU (1) | AU2001281248A1 (en) |
CA (1) | CA2418502A1 (en) |
WO (1) | WO2002018643A2 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7985539B2 (en) | 2002-05-07 | 2011-07-26 | Northwestern University | Nanoparticle probes with raman spectroscopic fingerprints for analyte detection |
US8323888B2 (en) | 1996-07-29 | 2012-12-04 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
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US6506564B1 (en) | 1996-07-29 | 2003-01-14 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
US6750016B2 (en) | 1996-07-29 | 2004-06-15 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
US6984491B2 (en) | 1996-07-29 | 2006-01-10 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
US7098320B1 (en) | 1996-07-29 | 2006-08-29 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
CA2262018C (en) | 1996-07-29 | 2007-10-02 | Nanosphere Llc | Nanoparticles having oligonucleotides attached thereto and uses therefor |
US6974669B2 (en) | 2000-03-28 | 2005-12-13 | Nanosphere, Inc. | Bio-barcodes based on oligonucleotide-modified nanoparticles |
AU774593C (en) | 2000-01-13 | 2005-06-23 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
AU7687001A (en) | 2000-07-11 | 2002-01-21 | Nanospherre Inc | Method of detection by enhancement of silver staining |
DE60228128D1 (en) | 2001-11-09 | 2008-09-18 | Nanosphere Inc | Bioconjugate NANOPARTICLE PROBES |
FR2841156B1 (en) * | 2002-06-19 | 2004-09-10 | Bio Merieux | NOVEL FLUORESCENT MAGNETIC PARTICLES, AS WELL AS CONJUGATES OF SUCH PARTICLES, AND DIAGNOSTIC, THERAPEUTIC OR PROPHYLACTIC COMPOSITIONS CONTAINING THEM |
US7153687B2 (en) | 2002-08-13 | 2006-12-26 | Hong Kong Dna Chips Limited | Apparatus and methods for detecting DNA in biological samples |
JP4732683B2 (en) * | 2003-12-29 | 2011-07-27 | ユニバーサル・バイオ・リサーチ株式会社 | Target substance detection method |
ES2242528B1 (en) | 2004-03-25 | 2006-12-01 | Consejo Sup. Investig. Cientificas | MAGNETIC NANOPARTICLES OF NOBLE METALS. |
JP2005292007A (en) | 2004-04-01 | 2005-10-20 | Seiko Epson Corp | Nucleic acid immobilizing method, and manufacturing method for biosensor using same |
JP5398982B2 (en) * | 2004-05-24 | 2014-01-29 | ミダテック リミテッド | Nanoparticles containing RNA ligands |
JP2006322709A (en) * | 2005-05-17 | 2006-11-30 | Institute Of Physical & Chemical Research | Substance fixing substrate |
JP4821219B2 (en) * | 2005-09-02 | 2011-11-24 | ニプロ株式会社 | Qualitative reaction specimen |
KR100816419B1 (en) * | 2005-10-14 | 2008-03-27 | 래플진(주) | Method for Isothermal Amplification of Nucleic Acids and Method for Detecting Nucleic Acids Using Simultaneous Isothermal Amplification of Nucleic Acids and Signal Probe |
WO2008018566A1 (en) * | 2006-08-10 | 2008-02-14 | The Furukawa Electric Co., Ltd. | Colloidal silica particle containing light-absorbing substance, nano light-absorbing material, absorption labeling nanobead kit, and method for detection or quantification of biological molecule using the colloidal silica particle containing light-absorbing substance |
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US9335292B2 (en) | 2011-10-13 | 2016-05-10 | Auburn University | Electrochemical proximity assay |
JP6375230B2 (en) | 2012-02-27 | 2018-08-15 | セルラー リサーチ, インコーポレイテッド | Compositions and kits for molecular counting |
KR20230074639A (en) | 2013-08-28 | 2023-05-30 | 벡톤 디킨슨 앤드 컴퍼니 | Massively parallel single cell analysis |
WO2016138496A1 (en) | 2015-02-27 | 2016-09-01 | Cellular Research, Inc. | Spatially addressable molecular barcoding |
US11535882B2 (en) | 2015-03-30 | 2022-12-27 | Becton, Dickinson And Company | Methods and compositions for combinatorial barcoding |
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JP6940484B2 (en) | 2015-09-11 | 2021-09-29 | セルラー リサーチ, インコーポレイテッド | Methods and compositions for library normalization |
US10301677B2 (en) | 2016-05-25 | 2019-05-28 | Cellular Research, Inc. | Normalization of nucleic acid libraries |
US10202641B2 (en) | 2016-05-31 | 2019-02-12 | Cellular Research, Inc. | Error correction in amplification of samples |
US10640763B2 (en) | 2016-05-31 | 2020-05-05 | Cellular Research, Inc. | Molecular indexing of internal sequences |
KR102363716B1 (en) | 2016-09-26 | 2022-02-18 | 셀룰러 리서치, 인크. | Determination of protein expression using reagents having barcoded oligonucleotide sequences |
US11319583B2 (en) | 2017-02-01 | 2022-05-03 | Becton, Dickinson And Company | Selective amplification using blocking oligonucleotides |
US10852274B2 (en) | 2017-03-09 | 2020-12-01 | Auburn University | Differential circuit for background correction in electrochemical measurements |
EP4345172A2 (en) | 2017-06-05 | 2024-04-03 | Becton, Dickinson and Company | Sample indexing for single cells |
US11505799B2 (en) | 2017-07-07 | 2022-11-22 | Innamed, Inc. | Aptamers for measuring lipoprotein levels |
CN112272710A (en) | 2018-05-03 | 2021-01-26 | 贝克顿迪金森公司 | High throughput omics sample analysis |
US11365409B2 (en) | 2018-05-03 | 2022-06-21 | Becton, Dickinson And Company | Molecular barcoding on opposite transcript ends |
US11560565B2 (en) | 2018-06-13 | 2023-01-24 | Auburn University | Electrochemical detection nanostructure, systems, and uses thereof |
JP7158969B2 (en) * | 2018-09-18 | 2022-10-24 | 株式会社東芝 | Organic probes and molecular detectors |
EP3861134A1 (en) | 2018-10-01 | 2021-08-11 | Becton, Dickinson and Company | Determining 5' transcript sequences |
US11932849B2 (en) | 2018-11-08 | 2024-03-19 | Becton, Dickinson And Company | Whole transcriptome analysis of single cells using random priming |
WO2020123384A1 (en) | 2018-12-13 | 2020-06-18 | Cellular Research, Inc. | Selective extension in single cell whole transcriptome analysis |
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WO2021146207A1 (en) | 2020-01-13 | 2021-07-22 | Becton, Dickinson And Company | Methods and compositions for quantitation of proteins and rna |
WO2021231779A1 (en) | 2020-05-14 | 2021-11-18 | Becton, Dickinson And Company | Primers for immune repertoire profiling |
US11932901B2 (en) | 2020-07-13 | 2024-03-19 | Becton, Dickinson And Company | Target enrichment using nucleic acid probes for scRNAseq |
US11739443B2 (en) | 2020-11-20 | 2023-08-29 | Becton, Dickinson And Company | Profiling of highly expressed and lowly expressed proteins |
WO2023192917A1 (en) * | 2022-03-29 | 2023-10-05 | Nautilus Subsidiary, Inc. | Integrated arrays for single-analyte processes |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993025709A1 (en) * | 1992-06-09 | 1993-12-23 | Medical Research Council | Preparation of nucleic acids |
WO1998004740A1 (en) * | 1996-07-29 | 1998-02-05 | Nanosphere Llc | Nanoparticles having oligonucleotides attached thereto and uses therefor |
WO1998017317A2 (en) * | 1996-10-23 | 1998-04-30 | Skw Trostberg Aktiengesellschaft | Process for producing biologically active polymer nanoparticle-nucleic acid conjugates |
US5900481A (en) * | 1996-11-06 | 1999-05-04 | Sequenom, Inc. | Bead linkers for immobilizing nucleic acids to solid supports |
WO1999060169A1 (en) * | 1998-05-20 | 1999-11-25 | Molecular Machines, Inc. | Multimolecular devices, drug delivery systems and single-molecule selection |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5849486A (en) * | 1993-11-01 | 1998-12-15 | Nanogen, Inc. | Methods for hybridization analysis utilizing electrically controlled hybridization |
AU2001232779A1 (en) * | 2000-01-24 | 2001-07-31 | Nanogen, Inc. | Systems and devices for photoelectrophoretic transport and hybridization of oligonucleotides |
-
2001
- 2001-08-10 AU AU2001281248A patent/AU2001281248A1/en not_active Abandoned
- 2001-08-10 EP EP01959723A patent/EP1362121A2/en not_active Withdrawn
- 2001-08-10 CA CA002418502A patent/CA2418502A1/en not_active Abandoned
- 2001-08-10 JP JP2002522548A patent/JP2004525607A/en active Pending
- 2001-08-10 WO PCT/US2001/025237 patent/WO2002018643A2/en active Application Filing
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993025709A1 (en) * | 1992-06-09 | 1993-12-23 | Medical Research Council | Preparation of nucleic acids |
WO1998004740A1 (en) * | 1996-07-29 | 1998-02-05 | Nanosphere Llc | Nanoparticles having oligonucleotides attached thereto and uses therefor |
WO1998017317A2 (en) * | 1996-10-23 | 1998-04-30 | Skw Trostberg Aktiengesellschaft | Process for producing biologically active polymer nanoparticle-nucleic acid conjugates |
US5900481A (en) * | 1996-11-06 | 1999-05-04 | Sequenom, Inc. | Bead linkers for immobilizing nucleic acids to solid supports |
WO1999060169A1 (en) * | 1998-05-20 | 1999-11-25 | Molecular Machines, Inc. | Multimolecular devices, drug delivery systems and single-molecule selection |
Non-Patent Citations (4)
Title |
---|
LETSINGER ET AL: "Chemistry of oligonucleotide -gold nanoparticle conjugates", PHOSPHORUS, SULFUR AND SILICON AND THE RELATED ELEMENTS (1999), 144-146, 359-362, XP008019085 * |
LETSINGER R L ET AL: "Use of a steroid cyclic disulfide anchor in constructing gold nanoparticle- oligonucleotide conjugates.", BIOCONJUGATE CHEMISTRY, (2000 MAR-APR) 11 (2) 289-91., XP002205939 * |
LI ZHI ET AL: "Multiple thiol-anchor capped DNA -gold nanoparticle conjugates.", NUCLEIC ACIDS RESEARCH, (2002 APR 1) 30 (7) 1558-62., XP002205940 * |
See also references of EP1362121A2 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8323888B2 (en) | 1996-07-29 | 2012-12-04 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
US7985539B2 (en) | 2002-05-07 | 2011-07-26 | Northwestern University | Nanoparticle probes with raman spectroscopic fingerprints for analyte detection |
Also Published As
Publication number | Publication date |
---|---|
WO2002018643A9 (en) | 2003-11-06 |
CA2418502A1 (en) | 2002-03-07 |
EP1362121A2 (en) | 2003-11-19 |
JP2004525607A (en) | 2004-08-26 |
AU2001281248A1 (en) | 2002-03-13 |
WO2002018643A2 (en) | 2002-03-07 |
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