WO2002022782A3 - Homologous 28-kilodalton immunodominant protein genes of ehrlichia canis and uses thereof - Google Patents

Homologous 28-kilodalton immunodominant protein genes of ehrlichia canis and uses thereof Download PDF

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Publication number
WO2002022782A3
WO2002022782A3 PCT/US2001/028759 US0128759W WO0222782A3 WO 2002022782 A3 WO2002022782 A3 WO 2002022782A3 US 0128759 W US0128759 W US 0128759W WO 0222782 A3 WO0222782 A3 WO 0222782A3
Authority
WO
WIPO (PCT)
Prior art keywords
homologous
ehrlichia canis
protein genes
canis
immunodominant protein
Prior art date
Application number
PCT/US2001/028759
Other languages
French (fr)
Other versions
WO2002022782A2 (en
Inventor
David H Walker
Xue-Jie Yu
Jere W Mcbride
Original Assignee
Res Dev Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to IL15487001A priority Critical patent/IL154870A0/en
Application filed by Res Dev Foundation filed Critical Res Dev Foundation
Priority to AU2001290926A priority patent/AU2001290926B2/en
Priority to MXPA03002145A priority patent/MXPA03002145A/en
Priority to KR1020037003641A priority patent/KR100837581B1/en
Priority to CA002421952A priority patent/CA2421952A1/en
Priority to JP2002527225A priority patent/JP2004508823A/en
Priority to NZ524678A priority patent/NZ524678A/en
Priority to BR0113818-9A priority patent/BR0113818A/en
Priority to AU9092601A priority patent/AU9092601A/en
Priority to EP01970986A priority patent/EP1317474A4/en
Publication of WO2002022782A2 publication Critical patent/WO2002022782A2/en
Publication of WO2002022782A3 publication Critical patent/WO2002022782A3/en
Priority to ZA2003/01886A priority patent/ZA200301886B/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/29—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Richettsiales (O)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The present invention is directed to the cloning, sequencing and expression of homologous immunoreactive 28-kDa protein genes, p28-1, -2, -3, -5, -6, -7, -9, from a polymorphic multiple gene family of Ehrlichia canis. Further disclosed is a multigene locus encoding all nine homologous 28-kDa protein genes of Ehrlichia canis. Recombinant Ehrlichia canis 28-kDa proteins react with convalescent phase antiserum from an E.canis-infected dog, and may be useful in the development of vaccines and serodiagnostics that are particularly effective for disease prevention and serodiagnosis.
PCT/US2001/028759 2000-09-12 2001-09-12 Homologous 28-kilodalton immunodominant protein genes of ehrlichia canis and uses thereof WO2002022782A2 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
JP2002527225A JP2004508823A (en) 2000-09-12 2001-09-12 Ehrlichia keinis homology 28 kilodalton immunodominant protein gene and use thereof
AU2001290926A AU2001290926B2 (en) 2000-09-12 2001-09-12 Homologous 28-kilodalton immunodominant protein genes of ehrlichia canis and uses thereof
MXPA03002145A MXPA03002145A (en) 2000-09-12 2001-09-12 Homologous 28-kilodalton immunodominant protein genes of ehrlichia canis and uses thereof.
KR1020037003641A KR100837581B1 (en) 2000-09-12 2001-09-12 Homologous 28-kilodalton immunodominant protein genes of Ehrlichia canis and uses thereof
CA002421952A CA2421952A1 (en) 2000-09-12 2001-09-12 Homologous 28-kilodalton immunodominant protein genes of ehrlichia canis and uses thereof
IL15487001A IL154870A0 (en) 2000-09-12 2001-09-12 Homologous 28-kilodalton immunodominant protein genes of ehrlichia canis and uses thereof
NZ524678A NZ524678A (en) 2000-09-12 2001-09-12 28kDa protein p28-9 from Ehrlichia Canis and uses thereof
EP01970986A EP1317474A4 (en) 2000-09-12 2001-09-12 Homologous 28-kilodalton immunodominant protein genes of ehrlichia canis and uses thereof
AU9092601A AU9092601A (en) 2000-09-12 2001-09-12 Homologous 28-kilodalton immunodominant protein genes of ehrlichia canis and uses thereof
BR0113818-9A BR0113818A (en) 2000-09-12 2001-09-12 Twenty-eight kilodalton immunodominant protein genes, homologous to and use of ehrlichia canis
ZA2003/01886A ZA200301886B (en) 2000-09-12 2003-03-07 Homologous 28-kilodalton immunodominant protein genes of ehrlichia canis and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/660,587 2000-09-12
US09/660,587 US6392023B1 (en) 1999-03-03 2000-09-12 Homologous 28-kilodalton immunodominant protein genes of Ehrlicha canis and uses thereof

Publications (2)

Publication Number Publication Date
WO2002022782A2 WO2002022782A2 (en) 2002-03-21
WO2002022782A3 true WO2002022782A3 (en) 2002-05-30

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Family Applications (1)

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PCT/US2001/028759 WO2002022782A2 (en) 2000-09-12 2001-09-12 Homologous 28-kilodalton immunodominant protein genes of ehrlichia canis and uses thereof

Country Status (14)

Country Link
US (5) US6392023B1 (en)
EP (1) EP1317474A4 (en)
JP (1) JP2004508823A (en)
KR (1) KR100837581B1 (en)
CN (2) CN1473166A (en)
AU (2) AU2001290926B2 (en)
BR (1) BR0113818A (en)
CA (1) CA2421952A1 (en)
IL (1) IL154870A0 (en)
MX (1) MXPA03002145A (en)
NZ (1) NZ524678A (en)
RU (1) RU2288952C2 (en)
WO (1) WO2002022782A2 (en)
ZA (1) ZA200301886B (en)

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Also Published As

Publication number Publication date
MXPA03002145A (en) 2004-05-04
US20030185849A1 (en) 2003-10-02
KR20030042461A (en) 2003-05-28
JP2004508823A (en) 2004-03-25
AU2001290926B2 (en) 2006-12-14
CN1473166A (en) 2004-02-04
US20040247616A1 (en) 2004-12-09
IL154870A0 (en) 2003-10-31
US7309583B2 (en) 2007-12-18
CN101307312A (en) 2008-11-19
RU2288952C2 (en) 2006-12-10
KR100837581B1 (en) 2008-06-13
US6660269B2 (en) 2003-12-09
US7344719B2 (en) 2008-03-18
US6392023B1 (en) 2002-05-21
US20030073095A1 (en) 2003-04-17
WO2002022782A2 (en) 2002-03-21
EP1317474A4 (en) 2005-11-16
EP1317474A2 (en) 2003-06-11
NZ524678A (en) 2004-11-26
AU9092601A (en) 2002-03-26
US20030096250A1 (en) 2003-05-22
ZA200301886B (en) 2005-01-26
CA2421952A1 (en) 2002-03-21
BR0113818A (en) 2004-06-29

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