WO2002024157A3 - Acryl adhesive useful in transdermal drug delivery systems - Google Patents

Acryl adhesive useful in transdermal drug delivery systems Download PDF

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Publication number
WO2002024157A3
WO2002024157A3 PCT/US2001/029241 US0129241W WO0224157A3 WO 2002024157 A3 WO2002024157 A3 WO 2002024157A3 US 0129241 W US0129241 W US 0129241W WO 0224157 A3 WO0224157 A3 WO 0224157A3
Authority
WO
WIPO (PCT)
Prior art keywords
drug delivery
delivery systems
transdermal drug
adhesive useful
acryl adhesive
Prior art date
Application number
PCT/US2001/029241
Other languages
French (fr)
Other versions
WO2002024157A2 (en
Inventor
Eric Silverberg
Rama Chandran
Paul B Foreman
Michael Philbin
Smita Shah
Original Assignee
Nat Starch Chem Invest
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nat Starch Chem Invest filed Critical Nat Starch Chem Invest
Priority to EP01973175.1A priority Critical patent/EP1318843B1/en
Priority to KR1020037003644A priority patent/KR100940245B1/en
Priority to AU2001292781A priority patent/AU2001292781A1/en
Priority to ES01973175T priority patent/ES2410532T3/en
Priority to JP2002528194A priority patent/JP2004509222A/en
Publication of WO2002024157A2 publication Critical patent/WO2002024157A2/en
Publication of WO2002024157A3 publication Critical patent/WO2002024157A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
    • C09J133/00—Adhesives based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Adhesives based on derivatives of such polymers
    • C09J133/04—Homopolymers or copolymers of esters
    • C09J133/06—Homopolymers or copolymers of esters of esters containing only carbon, hydrogen and oxygen, the oxygen atom being present only as part of the carboxyl radical
    • C09J133/08—Homopolymers or copolymers of acrylic acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive plasters or dressings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/58—Adhesives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
    • C09J133/00—Adhesives based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Adhesives based on derivatives of such polymers
    • C09J133/04—Homopolymers or copolymers of esters
    • C09J133/06—Homopolymers or copolymers of esters of esters containing only carbon, hydrogen and oxygen, the oxygen atom being present only as part of the carboxyl radical
    • C09J133/062—Copolymers with monomers not covered by C09J133/06

Abstract

An adhesive composition which lacks functional groups containing reactive hydrogen moieties and contains no post-polymerization chemical crosslinker finds use in transdermal drug delivery systems. The invention enables the administration of drugs containing a reactive functional group, which drugs have heretofore not been able to be administered by the transdermal route using conventional acrylic adhesives.
PCT/US2001/029241 2000-09-19 2001-09-18 Acryl adhesive useful in transdermal drug delivery systems WO2002024157A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP01973175.1A EP1318843B1 (en) 2000-09-19 2001-09-18 Acryl adhesive useful in transdermal drug delivery systems
KR1020037003644A KR100940245B1 (en) 2000-09-19 2001-09-18 Non-reactive adhesive useful in transdermal drug delivery systems
AU2001292781A AU2001292781A1 (en) 2000-09-19 2001-09-18 Acryl adhesive useful in transdermal drug delivery systems
ES01973175T ES2410532T3 (en) 2000-09-19 2001-09-18 Acryl adhesive useful in transdermal drug delivery systems
JP2002528194A JP2004509222A (en) 2000-09-19 2001-09-18 Non-reactive adhesives useful in transdermal drug delivery systems

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23424800P 2000-09-19 2000-09-19
US60/234,248 2000-09-19

Publications (2)

Publication Number Publication Date
WO2002024157A2 WO2002024157A2 (en) 2002-03-28
WO2002024157A3 true WO2002024157A3 (en) 2003-01-23

Family

ID=22880566

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/029241 WO2002024157A2 (en) 2000-09-19 2001-09-18 Acryl adhesive useful in transdermal drug delivery systems

Country Status (7)

Country Link
US (1) US9056060B2 (en)
EP (1) EP1318843B1 (en)
JP (2) JP2004509222A (en)
KR (1) KR100940245B1 (en)
AU (1) AU2001292781A1 (en)
ES (1) ES2410532T3 (en)
WO (1) WO2002024157A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9205090B2 (en) 2005-09-23 2015-12-08 Alza Corporation High enhancer-loading polyacrylate formulation for transdermal applications

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WO2002024157A2 (en) * 2000-09-19 2002-03-28 National Starch And Chemical Investment Holding Corporation Acryl adhesive useful in transdermal drug delivery systems
DE10141652B4 (en) 2001-08-24 2011-04-07 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system based on polyacrylate pressure-sensitive adhesives without functional groups and its use
DE10141650C1 (en) 2001-08-24 2002-11-28 Lohmann Therapie Syst Lts Safe transdermal therapeutic system for administration of fentanyl or analogous analgesics, having matrix layer of carboxy group-free polyacrylate adhesive providing high permeation rate
NZ582975A (en) 2004-10-21 2011-07-29 Durect Corp Transdermal delivery systems delivering sufentanil
US8252319B2 (en) 2004-10-21 2012-08-28 Durect Corporation Transdermal delivery system for sufentanil
US20070098772A1 (en) 2005-09-23 2007-05-03 Westcott Tyler D Transdermal norelgestromin delivery system
US20090130188A9 (en) * 2005-09-29 2009-05-21 National Starch And Chemical Investment Holding Company Acrylic pressure sensitive adhesives
DE102005050654A1 (en) * 2005-10-20 2007-04-26 LABTEC Gesellschaft für technologische Forschung und Entwicklung mbH lip paving
CA2643037C (en) * 2006-02-27 2014-08-05 Noven Pharmaceuticals, Inc. Compositions and methods for delivery of amino-functional drugs
US20100087768A1 (en) * 2008-10-02 2010-04-08 Forlano Paula Transdermal drug delivery system for liquid active ingredient
CA2891467A1 (en) 2012-10-15 2014-04-24 Noven Pharmaceuticals, Inc. Compositions and methods for the transdermal delivery of methylphenidate
US10493024B2 (en) 2015-10-12 2019-12-03 Hk Tumescent Pharma Corporation Tumescent infiltration drug delivery of high subcutaneous drug concentrations with prolonged local and systemic effects and minimal local or systemic toxicity
US11241412B2 (en) 2015-10-12 2022-02-08 Hk Pharma Tumescent infiltration drug delivery of cannabinoids
EP3612611B1 (en) * 2017-04-17 2020-12-16 3M Innovative Properties Company Blended block copolymer/silicone pressure sensitive adhesives
WO2019209940A1 (en) * 2018-04-25 2019-10-31 Shinkei Therapeutics Llc Tetrabenazine transdermal delivery device
KR102207590B1 (en) * 2018-08-06 2021-01-26 고세윤 Adhesive Composition for Anti-Irritation of Skin Comprising Biomedical Polymer and Adhesive Sheet Thereof
MX2022000274A (en) * 2019-07-11 2022-02-03 Henkel Ag & Co Kgaa Acrylic polymer and adhesive compositions.
EP3854388B1 (en) 2020-01-24 2023-10-04 Luye Pharma Switzerland AG Transdermal therapeutic system comprising rotigotine and at least one non-amine-resistant silicone adhesive

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GB1081298A (en) * 1963-08-01 1967-08-31 Johnson & Johnson Pressure-sensitive adhesive composition
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9205090B2 (en) 2005-09-23 2015-12-08 Alza Corporation High enhancer-loading polyacrylate formulation for transdermal applications
US9446004B2 (en) 2005-09-23 2016-09-20 Alza Corporation Transdermal nicotine salt delivery system

Also Published As

Publication number Publication date
US20020077437A1 (en) 2002-06-20
US9056060B2 (en) 2015-06-16
WO2002024157A2 (en) 2002-03-28
EP1318843A2 (en) 2003-06-18
KR20040030408A (en) 2004-04-09
AU2001292781A1 (en) 2002-04-02
KR100940245B1 (en) 2010-02-04
JP2013163820A (en) 2013-08-22
JP2004509222A (en) 2004-03-25
JP5702434B2 (en) 2015-04-15
EP1318843B1 (en) 2013-04-17
ES2410532T3 (en) 2013-07-02

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