WO2002026757A3 - Modulation of immunostimulatory activity of immunostimulatory oligonucleotide analogs by positional chemical changes - Google Patents

Modulation of immunostimulatory activity of immunostimulatory oligonucleotide analogs by positional chemical changes Download PDF

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Publication number
WO2002026757A3
WO2002026757A3 PCT/US2001/030137 US0130137W WO0226757A3 WO 2002026757 A3 WO2002026757 A3 WO 2002026757A3 US 0130137 W US0130137 W US 0130137W WO 0226757 A3 WO0226757 A3 WO 0226757A3
Authority
WO
WIPO (PCT)
Prior art keywords
immunostimulatory
modulation
oligonucleotide analogs
chemical changes
activity
Prior art date
Application number
PCT/US2001/030137
Other languages
French (fr)
Other versions
WO2002026757A2 (en
Inventor
Ekambar R Kandimalla
Quiyan Zhao
Dong Yu
Sudhir Agrawal
Original Assignee
Hybridon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hybridon Inc filed Critical Hybridon Inc
Priority to AU2001294750A priority Critical patent/AU2001294750C1/en
Priority to JP2002531140A priority patent/JP2004509970A/en
Priority to DE60132471T priority patent/DE60132471T2/en
Priority to EP01975423A priority patent/EP1322656B1/en
Priority to AU9475001A priority patent/AU9475001A/en
Priority to KR1020037004314A priority patent/KR100865706B1/en
Priority to CA2423487A priority patent/CA2423487C/en
Publication of WO2002026757A2 publication Critical patent/WO2002026757A2/en
Publication of WO2002026757A3 publication Critical patent/WO2002026757A3/en
Priority to AU2006203435A priority patent/AU2006203435B2/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/18—Type of nucleic acid acting by a non-sequence specific mechanism
    • C—CHEMISTRY; METALLURGY
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/312—Phosphonates
    • C12N2310/3125—Methylphosphonates
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/317—Chemical structure of the backbone with an inverted bond, e.g. a cap structure
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/334—Modified C
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/336—Modified G

Abstract

The invention relates to the therapeutic use of oligonucleotides or oligonucleotide analogs as immunostimulatory agents in immunotherapy applications. The invention provides methods for enhancing the immune response caused by immunostimulatory oligonucleotide compounds.
PCT/US2001/030137 2000-09-26 2001-09-26 Modulation of immunostimulatory activity of immunostimulatory oligonucleotide analogs by positional chemical changes WO2002026757A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
AU2001294750A AU2001294750C1 (en) 2000-09-26 2001-09-26 Modulation of immunostimulatory activity of immunostimulatory oligonucleotide analogs by positional chemical changes
JP2002531140A JP2004509970A (en) 2000-09-26 2001-09-26 Regulation of immunostimulatory activity of immunostimulatory oligonucleotide analogues by positional chemical changes
DE60132471T DE60132471T2 (en) 2000-09-26 2001-09-26 MODULATION OF THE IMMUNOSTIMULATORY ACTIVITY OF IMMUNOSTIMULATING OLIGONUCLEOTIDE ANALOGUES BY POSITIONAL CHEMICAL CHANGES
EP01975423A EP1322656B1 (en) 2000-09-26 2001-09-26 Modulation of immunostimulatory activity of immunostimulatory oligonucleotide analogs by positional chemical changes
AU9475001A AU9475001A (en) 2000-09-26 2001-09-26 Modulation of immunostimulatory activity of immunostimulatory oligonucleotide analogs by positional chemical changes
KR1020037004314A KR100865706B1 (en) 2000-09-26 2001-09-26 Modulation of immunostimulatory activity of immunostimulatory oligonucleotide analogs by positional chemical changes
CA2423487A CA2423487C (en) 2000-09-26 2001-09-26 Modulation of immunostimulatory activity of immunostimulatory oligonucleotide analogs by positional chemical changes
AU2006203435A AU2006203435B2 (en) 2000-09-26 2006-08-09 Modulation of immunostimulatory activity of immunostimulatory oligonucleotide analogs by positional chemical changes

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US23545200P 2000-09-26 2000-09-26
US23545300P 2000-09-26 2000-09-26
US60/235,452 2000-09-26
US60/235,453 2000-09-26
US71289800A 2000-11-15 2000-11-15
US09/712,898 2000-11-15

Publications (2)

Publication Number Publication Date
WO2002026757A2 WO2002026757A2 (en) 2002-04-04
WO2002026757A3 true WO2002026757A3 (en) 2003-01-03

Family

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Application Number Title Priority Date Filing Date
PCT/US2001/030137 WO2002026757A2 (en) 2000-09-26 2001-09-26 Modulation of immunostimulatory activity of immunostimulatory oligonucleotide analogs by positional chemical changes

Country Status (10)

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US (8) US7262286B2 (en)
EP (2) EP1322656B1 (en)
JP (1) JP2004509970A (en)
KR (2) KR100865706B1 (en)
AT (1) ATE384072T1 (en)
AU (2) AU2001294750C1 (en)
CA (1) CA2423487C (en)
DE (1) DE60132471T2 (en)
ES (1) ES2298269T3 (en)
WO (1) WO2002026757A2 (en)

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US9376669B2 (en) 2012-11-01 2016-06-28 Factor Bioscience Inc. Methods and products for expressing proteins in cells
US9422577B2 (en) 2011-12-05 2016-08-23 Factor Bioscience Inc. Methods and products for transfecting cells

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