WO2002033410A3 - Microvolume immunoabsorbant assays with amplified electrochemical detection - Google Patents
Microvolume immunoabsorbant assays with amplified electrochemical detection Download PDFInfo
- Publication number
- WO2002033410A3 WO2002033410A3 PCT/US2001/032552 US0132552W WO0233410A3 WO 2002033410 A3 WO2002033410 A3 WO 2002033410A3 US 0132552 W US0132552 W US 0132552W WO 0233410 A3 WO0233410 A3 WO 0233410A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- electrochemical detection
- microvolume
- combined
- assay techniques
- assays
- Prior art date
Links
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
- B01F33/3032—Micromixers using magneto-hydrodynamic [MHD] phenomena to mix or move the fluids
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
- B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B17/00—Pumps characterised by combination with, or adaptation to, specific driving engines or motors
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
- G01N27/3277—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction being a redox reaction, e.g. detection by cyclic voltammetry
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
- G01N33/5438—Electrodes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00306—Reactor vessels in a multiple arrangement
- B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
- B01J2219/00315—Microtiter plates
- B01J2219/00317—Microwell devices, i.e. having large numbers of wells
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/00511—Walls of reactor vessels
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00585—Parallel processes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00596—Solid-phase processes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00653—Making arrays on substantially continuous surfaces the compounds being bound to electrodes embedded in or on the solid supports
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00659—Two-dimensional arrays
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/0068—Means for controlling the apparatus of the process
- B01J2219/00702—Processes involving means for analysing and characterising the products
- B01J2219/00704—Processes involving means for analysing and characterising the products integrated with the reactor apparatus
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0605—Metering of fluids
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/043—Moving fluids with specific forces or mechanical means specific forces magnetic forces
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
- C12Q2565/60—Detection means characterised by use of a special device
- C12Q2565/607—Detection means characterised by use of a special device being a sensor, e.g. electrode
Abstract
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU1461702A AU1461702A (en) | 2000-10-16 | 2001-10-16 | Microvolume immunoabsorbant assays with amplified electrochemical detection |
EP01983168A EP1326712A2 (en) | 2000-10-16 | 2001-10-16 | Microvolume immunoabsorbant assays with amplified electrochemical detection |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24069100P | 2000-10-16 | 2000-10-16 | |
US60/240,691 | 2000-10-16 | ||
US09/978,734 | 2001-10-15 | ||
US09/978,734 US6887714B2 (en) | 2000-10-16 | 2001-10-15 | Microvolume immunoabsorbant assays with amplified electrochemical detection |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2002033410A2 WO2002033410A2 (en) | 2002-04-25 |
WO2002033410A3 true WO2002033410A3 (en) | 2002-07-04 |
Family
ID=26933626
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/032552 WO2002033410A2 (en) | 2000-10-16 | 2001-10-16 | Microvolume immunoabsorbant assays with amplified electrochemical detection |
Country Status (4)
Country | Link |
---|---|
US (1) | US6887714B2 (en) |
EP (1) | EP1326712A2 (en) |
AU (1) | AU1461702A (en) |
WO (1) | WO2002033410A2 (en) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7348183B2 (en) | 2000-10-16 | 2008-03-25 | Board Of Trustees Of The University Of Arkansas | Self-contained microelectrochemical bioassay platforms and methods |
US7074519B2 (en) * | 2001-10-26 | 2006-07-11 | The Regents Of The University Of California | Molehole embedded 3-D crossbar architecture used in electrochemical molecular memory device |
GB0130684D0 (en) * | 2001-12-21 | 2002-02-06 | Oxford Biosensors Ltd | Micro-band electrode |
US9740817B1 (en) | 2002-10-18 | 2017-08-22 | Dennis Sunga Fernandez | Apparatus for biological sensing and alerting of pharmaco-genomic mutation |
EP1601760A4 (en) * | 2003-02-28 | 2009-08-19 | Univ Brown | Nanopores, methods for using same, methods for making same and methods for characterizing biomolecules using same |
US8346482B2 (en) | 2003-08-22 | 2013-01-01 | Fernandez Dennis S | Integrated biosensor and simulation system for diagnosis and therapy |
US7001717B2 (en) * | 2003-12-05 | 2006-02-21 | Biofx Laboratories, Inc. | Charcoal stabilization of phenyl phosphates |
US20060008581A1 (en) * | 2004-07-09 | 2006-01-12 | Mark Hyland | Method of manufacturing an electrochemical sensor |
CA2513340A1 (en) * | 2004-08-25 | 2006-02-25 | F. Hoffmann-La Roche Ag | Reusable substrate for dna microarray production |
US20070037232A1 (en) | 2005-03-31 | 2007-02-15 | Barasch Jonathan M | Detection of NGAL in chronic renal disease |
US20070190542A1 (en) * | 2005-10-03 | 2007-08-16 | Ling Xinsheng S | Hybridization assisted nanopore sequencing |
US20080305512A1 (en) * | 2006-10-26 | 2008-12-11 | Mattingly Phillip G | Assay for cardiac troponin autoantibodies |
US7776605B2 (en) | 2006-10-26 | 2010-08-17 | Abbott Laboratories | Assay for cardiac troponin autoantibodies |
CA2667012A1 (en) * | 2006-10-26 | 2008-05-02 | Abbott Laboratories | Immunoassay of analytes in samples containing endogenous anti-analyte antibodies |
EP2118657B1 (en) | 2006-12-29 | 2014-05-21 | Abbott Laboratories | Non-denaturing lysis reagent for use with capture-in-solution immunoassay |
US7914999B2 (en) | 2006-12-29 | 2011-03-29 | Abbott Laboratories | Non-denaturing lysis reagent |
US20080220537A1 (en) * | 2007-03-07 | 2008-09-11 | Pacific Biosciences Of California, Inc. | Substrates and methods for selective immobilization of active molecules |
EP2201136B1 (en) * | 2007-10-01 | 2017-12-06 | Nabsys 2.0 LLC | Nanopore sequencing by hybridization of probes to form ternary complexes and variable range alignment |
GB0801142D0 (en) * | 2008-01-22 | 2008-02-27 | Imp Innovations Ltd | Label-free molecule detection and measurement |
US9650668B2 (en) | 2008-09-03 | 2017-05-16 | Nabsys 2.0 Llc | Use of longitudinally displaced nanoscale electrodes for voltage sensing of biomolecules and other analytes in fluidic channels |
US8262879B2 (en) | 2008-09-03 | 2012-09-11 | Nabsys, Inc. | Devices and methods for determining the length of biopolymers and distances between probes bound thereto |
WO2010028140A2 (en) * | 2008-09-03 | 2010-03-11 | Nabsys, Inc. | Use of longitudinally displaced nanoscale electrodes for voltage sensing of biomolecules and other analytes in fluidic channels |
US8455260B2 (en) * | 2009-03-27 | 2013-06-04 | Massachusetts Institute Of Technology | Tagged-fragment map assembly |
WO2010111605A2 (en) * | 2009-03-27 | 2010-09-30 | Nabsys, Inc. | Devices and methods for analyzing biomolecules and probes bound thereto |
US8246799B2 (en) * | 2009-05-28 | 2012-08-21 | Nabsys, Inc. | Devices and methods for analyzing biomolecules and probes bound thereto |
US8835120B2 (en) * | 2009-12-02 | 2014-09-16 | Abbott Laboratories | Assay for cardiac troponin-T (cTnT) |
US8652788B2 (en) * | 2009-12-02 | 2014-02-18 | Abbott Laboratories | Assay for diagnosis of cardiac myocyte damage |
US8183002B2 (en) * | 2009-12-03 | 2012-05-22 | Abbott Laboratories | Autoantibody enhanced immunoassays and kits |
US20110136141A1 (en) * | 2009-12-03 | 2011-06-09 | Abbott Laboratories | Peptide reagents and method for inhibiting autoantibody antigen binding |
US8901433B2 (en) | 2010-09-10 | 2014-12-02 | Hitachi Chemical Co., Ltd. | Individually addressable band electrode arrays and methods to prepare the same |
US8715933B2 (en) | 2010-09-27 | 2014-05-06 | Nabsys, Inc. | Assay methods using nicking endonucleases |
EP2640849B1 (en) | 2010-11-16 | 2016-04-06 | Nabsys 2.0 LLC | Methods for sequencing a biomolecule by detecting relative positions of hybridized probes |
US11274341B2 (en) | 2011-02-11 | 2022-03-15 | NABsys, 2.0 LLC | Assay methods using DNA binding proteins |
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CN107102135A (en) | 2011-05-20 | 2017-08-29 | 阿波特日本有限公司 | Immunity inspection method and reagent for reducing non-specific binding |
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US9910008B2 (en) | 2012-07-06 | 2018-03-06 | Robert Bosch Gmbh | Methods for generating pH/ionic concentration gradient near electrode surfaces for modulating biomolecular interactions |
US9874538B2 (en) | 2012-07-06 | 2018-01-23 | Robert Bosch Gmbh | Methods for generating pH/ionic concentration gradient near electrode surfaces for modulating biomolecular interactions |
US9075041B2 (en) | 2012-07-06 | 2015-07-07 | Robert Bosch Gmbh | Methods for generating pH/ionic concentration gradient near electrode surfaces for modulating biomolecular interactions |
US9914966B1 (en) | 2012-12-20 | 2018-03-13 | Nabsys 2.0 Llc | Apparatus and methods for analysis of biomolecules using high frequency alternating current excitation |
WO2014113557A1 (en) | 2013-01-18 | 2014-07-24 | Nabsys, Inc. | Enhanced probe binding |
WO2015121206A1 (en) | 2014-02-13 | 2015-08-20 | Robert Bosch Gmbh | Capacitive bubble detection |
US10670595B2 (en) * | 2015-05-26 | 2020-06-02 | Oncogenesis, Inc. | System, method and kit for detection of analytes by production of electrochemical species |
US11867660B2 (en) | 2015-07-06 | 2024-01-09 | Robert Bosch Gmbh | Electronic control of the pH of a solution close to an electrode surface |
US10379080B2 (en) | 2015-07-06 | 2019-08-13 | Robert Bosch Gmbh | Electronic control of the pH of a solution close to an electrode surfaces |
US10011549B2 (en) | 2015-07-06 | 2018-07-03 | Robert Bosch Gmbh | Electrochemically active agents for pH modulation in biological buffers |
JP6273315B2 (en) * | 2016-05-16 | 2018-01-31 | インテル コーポレイション | Nanogap transducer with selective surface immobilization sites |
CN106513068B (en) * | 2016-10-25 | 2018-10-30 | 清华大学 | The solution and its application that micro-fluidic chip bonding for polymerizable material is modified with surface |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5554339A (en) * | 1988-11-14 | 1996-09-10 | I-Stat Corporation | Process for the manufacture of wholly microfabricated biosensors |
WO1997021094A1 (en) * | 1995-12-01 | 1997-06-12 | Innogenetics N.V. | Impedimetric detection system and method of production thereof |
Family Cites Families (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8402058D0 (en) * | 1984-01-26 | 1984-02-29 | Serono Diagnostics Ltd | Methods of assay |
US4779031A (en) | 1985-12-30 | 1988-10-18 | Intellico, Inc. | Motor system |
JPH0797696B2 (en) | 1986-07-05 | 1995-10-18 | 株式会社豊田自動織機製作所 | Hybrid IC substrate and circuit pattern forming method |
US4961806A (en) | 1986-12-10 | 1990-10-09 | Sanders Associates, Inc. | Method of making a printed circuit |
US4972470A (en) | 1987-08-06 | 1990-11-20 | Steven Farago | Programmable connector |
US5634267A (en) | 1991-06-04 | 1997-06-03 | Micron Technology, Inc. | Method and apparatus for manufacturing known good semiconductor die |
US5053920A (en) | 1989-06-09 | 1991-10-01 | Digital Equipment Corporation | Integrated power conversion |
JP2835116B2 (en) | 1989-09-29 | 1998-12-14 | 株式会社東芝 | Power IC and method of manufacturing the same |
JPH0834709B2 (en) | 1990-01-31 | 1996-03-29 | 株式会社日立製作所 | Semiconductor integrated circuit and electric motor control device using the same |
JP3280394B2 (en) | 1990-04-05 | 2002-05-13 | ロックヒード マーティン コーポレーション | Electronic equipment |
JPH0513562A (en) | 1991-07-05 | 1993-01-22 | Hitachi Ltd | Driving control device |
US5355301A (en) | 1992-02-28 | 1994-10-11 | Fuji Electric Co., Ltd. | One-chip type switching power supply device |
DE4219031C2 (en) | 1992-06-10 | 1994-11-10 | Siemens Ag | Multi-chip module with capacitor, which is realized on the carrier made of silicon (monocrystalline substrate) |
IT1255190B (en) | 1992-06-30 | 1995-10-20 | Giuseppe Marchisi | CONTROL INTERFACE DEVICE FOR AN ELECTRIC MOTOR |
US5544017A (en) | 1992-08-05 | 1996-08-06 | Fujitsu Limited | Multichip module substrate |
US5384691A (en) | 1993-01-08 | 1995-01-24 | General Electric Company | High density interconnect multi-chip modules including embedded distributed power supply elements |
US5410107A (en) | 1993-03-01 | 1995-04-25 | The Board Of Trustees Of The University Of Arkansas | Multichip module |
EP0645810A4 (en) | 1993-04-06 | 1997-04-16 | Tokuyama Corp | Package for semiconductor chip. |
US5413939A (en) * | 1993-06-29 | 1995-05-09 | First Medical, Inc. | Solid-phase binding assay system for interferometrically measuring analytes bound to an active receptor |
JP3325351B2 (en) | 1993-08-18 | 2002-09-17 | 株式会社東芝 | Semiconductor device |
US5432675A (en) | 1993-11-15 | 1995-07-11 | Fujitsu Limited | Multi-chip module having thermal contacts |
JP3123343B2 (en) | 1994-05-11 | 2001-01-09 | 富士電機株式会社 | Stabilized power supply and manufacturing method thereof |
JP3307506B2 (en) | 1994-07-13 | 2002-07-24 | 三菱電機株式会社 | Control device for vehicle alternator and vehicle alternator |
US5434745A (en) | 1994-07-26 | 1995-07-18 | White Microelectronics Div. Of Bowmar Instrument Corp. | Stacked silicon die carrier assembly |
JP3230953B2 (en) | 1994-07-28 | 2001-11-19 | 富士通株式会社 | Multilayer thin film wiring board |
US5532512A (en) | 1994-10-03 | 1996-07-02 | General Electric Company | Direct stacked and flip chip power semiconductor device structures |
US5608617A (en) | 1996-05-03 | 1997-03-04 | Zecal Incorporated | High power miniature demand power supply |
US5495394A (en) | 1994-12-19 | 1996-02-27 | At&T Global Information Solutions Company | Three dimensional die packaging in multi-chip modules |
HUP9801679A3 (en) * | 1995-03-10 | 2001-01-29 | Meso Scale Technologies Llc Co | Process and agent for multi-array, multi-specific electrochemiluminescence testing |
US5616888A (en) | 1995-09-29 | 1997-04-01 | Allen-Bradley Company, Inc. | Rigid-flex circuit board having a window for an insulated mounting area |
US5641944A (en) | 1995-09-29 | 1997-06-24 | Allen-Bradley Company, Inc. | Power substrate with improved thermal characteristics |
US5753517A (en) * | 1996-03-29 | 1998-05-19 | University Of British Columbia | Quantitative immunochromatographic assays |
US5958791A (en) * | 1996-09-27 | 1999-09-28 | Innovative Biotechnologies, Inc. | Interdigitated electrode arrays for liposome-enhanced immunoassay and test device |
US7014992B1 (en) * | 1996-11-05 | 2006-03-21 | Clinical Micro Sensors, Inc. | Conductive oligomers attached to electrodes and nucleoside analogs |
US6740518B1 (en) * | 1998-09-17 | 2004-05-25 | Clinical Micro Sensors, Inc. | Signal detection techniques for the detection of analytes |
US6485983B1 (en) * | 1999-05-05 | 2002-11-26 | Intec Science, Inc. | System for electrochemical quantitative analysis of analytes within a solid phase and affinity chromatographic test strip |
US6391624B1 (en) * | 1999-06-03 | 2002-05-21 | Lockheed Martin Corporation | Highly sensitive biological agent probe |
-
2001
- 2001-10-15 US US09/978,734 patent/US6887714B2/en not_active Expired - Lifetime
- 2001-10-16 EP EP01983168A patent/EP1326712A2/en not_active Withdrawn
- 2001-10-16 AU AU1461702A patent/AU1461702A/en active Pending
- 2001-10-16 WO PCT/US2001/032552 patent/WO2002033410A2/en active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5554339A (en) * | 1988-11-14 | 1996-09-10 | I-Stat Corporation | Process for the manufacture of wholly microfabricated biosensors |
WO1997021094A1 (en) * | 1995-12-01 | 1997-06-12 | Innogenetics N.V. | Impedimetric detection system and method of production thereof |
Non-Patent Citations (5)
Title |
---|
DENYER M C T ET AL: "PRELIMINARY STUDY ON THE SUITABILITY OF A PHARMACOLOGICAL BIO-ASSAYBASED ON CARDIAC MYOCYTES CULTURED OVER MICROFABRICATED MICROELECTRODE ARRAYS", MEDICAL AND BIOLOGICAL ENGINEERING AND COMPUTING, PETER PEREGRINUS LTD. STEVENAGE, GB, vol. 36, no. 5, 1 September 1998 (1998-09-01), pages 638 - 644, XP000777560, ISSN: 0140-0118 * |
HINTSCHE R ET AL: "MICROBIOSENSORS USING ELECTRODES MADE IN SI-TECHNOLOGY", EXS, BIRKHAEUSER VERLAG, BASEL, CH, PAGE(S) 267-283, ISSN: 1023-294X, XP000863543 * |
KONIG A ET AL: "Multimicrobial sensor using microstructured three-dimensional electrodes based on silicon technology.", ANALYTICAL CHEMISTRY, (2000 MAY 1) 72 (9) 2022-8., XP002194343 * |
KOSSEK S ET AL: "IMMOBILIZATION OF STREPTAVIDIN FOR IMMUNOSENSORS ON NANOSTRUCTURED SURFACES", JOURNAL OF MOLECULAR RECOGNITION, HEYDEN & SON LTD., LONDON, GB, vol. 9, 1996, pages 485 - 487, XP000886890, ISSN: 0952-3499 * |
VAN GERWEN P ET AL: "Nanoscaled interdigitated electrode arrays for biochemical sensors", 1997 INTERNATIONAL CONFERENCE ON SOLID-STATE SENSORS AND ACTUATORS. DIGEST OF TECHNICAL PAPERS. TRANSDUCERS 97. CHICAGO, IL, JUNE 16 - 19, 1997. SESSIONS 3A1 - 4D3. PAPERS NO. 3A1.01 - 4D3.14P, INTERNATIONAL CONFERENCE ON SOLID-STATE SENSORS AND ACTU, vol. 2, 16 June 1997 (1997-06-16), pages 907 - 910, XP010240622, ISBN: 0-7803-3829-4 * |
Also Published As
Publication number | Publication date |
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EP1326712A2 (en) | 2003-07-16 |
US6887714B2 (en) | 2005-05-03 |
WO2002033410A2 (en) | 2002-04-25 |
AU1461702A (en) | 2002-04-29 |
US20020058279A1 (en) | 2002-05-16 |
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