WO2002040874A1 - Apparatus and methods for conducting assays and high throughput screening - Google Patents
Apparatus and methods for conducting assays and high throughput screening Download PDFInfo
- Publication number
- WO2002040874A1 WO2002040874A1 PCT/US2001/044869 US0144869W WO0240874A1 WO 2002040874 A1 WO2002040874 A1 WO 2002040874A1 US 0144869 W US0144869 W US 0144869W WO 0240874 A1 WO0240874 A1 WO 0240874A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- flow channel
- solution
- branch flow
- assay
- channels
- Prior art date
Links
Classifications
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B43/00—Machines, pumps, or pumping installations having flexible working members
- F04B43/12—Machines, pumps, or pumping installations having flexible working members having peristaltic action
- F04B43/14—Machines, pumps, or pumping installations having flexible working members having peristaltic action having plate-like flexible members
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D57/00—Separation, other than separation of solids, not fully covered by a single other group or subclass, e.g. B03C
- B01D57/02—Separation, other than separation of solids, not fully covered by a single other group or subclass, e.g. B03C by electrophoresis
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
- B01D61/18—Apparatus therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/24—Dialysis ; Membrane extraction
- B01D61/28—Apparatus therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
- B01D63/08—Flat membrane modules
- B01D63/081—Manufacturing thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
- B01D63/08—Flat membrane modules
- B01D63/088—Microfluidic devices comprising semi-permeable flat membranes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/40—Static mixers
- B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
- B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
- B01F25/433—Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/40—Static mixers
- B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
- B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
- B01F25/433—Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
- B01F25/4331—Mixers with bended, curved, coiled, wounded mixing tubes or comprising elements for bending the flow
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
- B01F31/65—Mixers with shaking, oscillating, or vibrating mechanisms the materials to be mixed being directly submitted to a pulsating movement, e.g. by means of an oscillating piston or air column
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/80—Mixing plants; Combinations of mixers
- B01F33/81—Combinations of similar mixers, e.g. with rotary stirring devices in two or more receptacles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/80—Mixing plants; Combinations of mixers
- B01F33/81—Combinations of similar mixers, e.g. with rotary stirring devices in two or more receptacles
- B01F33/813—Combinations of similar mixers, e.g. with rotary stirring devices in two or more receptacles mixing simultaneously in two or more mixing receptacles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/16—Microfluidic devices; Capillary tubes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B43/00—Machines, pumps, or pumping installations having flexible working members
- F04B43/02—Machines, pumps, or pumping installations having flexible working members having plate-like flexible members, e.g. diaphragms
- F04B43/04—Pumps having electric drive
- F04B43/043—Micropumps
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K99/0001—Microvalves
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K99/0001—Microvalves
- F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
- F16K99/0005—Lift valves
- F16K99/0009—Lift valves the valve element held by multiple arms
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K99/0001—Microvalves
- F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
- F16K99/0015—Diaphragm or membrane valves
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K99/0001—Microvalves
- F16K99/0034—Operating means specially adapted for microvalves
- F16K99/0042—Electric operating means therefor
- F16K99/0046—Electric operating means therefor using magnets
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K99/0001—Microvalves
- F16K99/0034—Operating means specially adapted for microvalves
- F16K99/0042—Electric operating means therefor
- F16K99/0048—Electric operating means therefor using piezoelectric means
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K99/0001—Microvalves
- F16K99/0034—Operating means specially adapted for microvalves
- F16K99/0042—Electric operating means therefor
- F16K99/0051—Electric operating means therefor using electrostatic means
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K99/0001—Microvalves
- F16K99/0034—Operating means specially adapted for microvalves
- F16K99/0055—Operating means specially adapted for microvalves actuated by fluids
- F16K99/0059—Operating means specially adapted for microvalves actuated by fluids actuated by a pilot fluid
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
- G01N15/06—Investigating concentration of particle suspensions
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44704—Details; Accessories
- G01N27/44743—Introducing samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44756—Apparatus specially adapted therefor
- G01N27/44791—Microapparatus
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2313/00—Details relating to membrane modules or apparatus
- B01D2313/08—Flow guidance means within the module or the apparatus
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2313/00—Details relating to membrane modules or apparatus
- B01D2313/60—Specific sensors or sensor arrangements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2313/00—Details relating to membrane modules or apparatus
- B01D2313/90—Additional auxiliary systems integrated with the module or apparatus
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0631—Purification arrangements, e.g. solid phase extraction [SPE]
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0645—Electrodes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0681—Filter
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0877—Flow chambers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0887—Laminated structure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/12—Specific details about materials
- B01L2300/123—Flexible; Elastomeric
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
- B01L2300/1822—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using Peltier elements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
- B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0633—Valves, specific forms thereof with moving parts
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0633—Valves, specific forms thereof with moving parts
- B01L2400/0655—Valves, specific forms thereof with moving parts pinch valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/08—Regulating or influencing the flow resistance
- B01L2400/082—Active control of flow resistance, e.g. flow controllers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K2099/0073—Fabrication methods specifically adapted for microvalves
- F16K2099/0074—Fabrication methods specifically adapted for microvalves using photolithography, e.g. etching
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K2099/0073—Fabrication methods specifically adapted for microvalves
- F16K2099/008—Multi-layer fabrications
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K2099/0082—Microvalves adapted for a particular use
- F16K2099/0084—Chemistry or biology, e.g. "lab-on-a-chip" technology
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
- Y10T436/117497—Automated chemical analysis with a continuously flowing sample or carrier stream
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/2575—Volumetric liquid transfer
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Mechanical Engineering (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Zoology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Clinical Laboratory Science (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Water Supply & Treatment (AREA)
- Tropical Medicine & Parasitology (AREA)
- Electrochemistry (AREA)
- Sustainable Development (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- Manufacturing & Machinery (AREA)
- Environmental & Geological Engineering (AREA)
- Fluid Mechanics (AREA)
- Toxicology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
Description
Claims
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2002230524A AU2002230524A1 (en) | 2000-11-16 | 2001-11-16 | Apparatus and methods for conducting assays and high throughput screening |
EP01990762.5A EP1343973B2 (en) | 2000-11-16 | 2001-11-16 | Apparatus and methods for conducting assays and high throughput screening |
US10/416,418 US7378280B2 (en) | 2000-11-16 | 2001-11-16 | Apparatus and methods for conducting assays and high throughput screening |
US12/127,720 US7887753B2 (en) | 2000-11-16 | 2008-05-27 | Apparatus and methods for conducting assays and high throughput screening |
US13/026,587 US8273574B2 (en) | 2000-11-16 | 2011-02-14 | Apparatus and methods for conducting assays and high throughput screening |
US13/027,768 US8455258B2 (en) | 2000-11-16 | 2011-02-15 | Apparatus and methods for conducting assays and high throughput screening |
US13/603,263 US8673645B2 (en) | 2000-11-16 | 2012-09-04 | Apparatus and methods for conducting assays and high throughput screening |
US14/216,740 US9176137B2 (en) | 2000-11-16 | 2014-03-17 | Apparatus and methods for conducting assays and high throughput screening |
US14/928,631 US10509018B2 (en) | 2000-11-16 | 2015-10-30 | Apparatus and methods for conducting assays and high throughput screening |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24932700P | 2000-11-16 | 2000-11-16 | |
US60/249,327 | 2000-11-16 | ||
US28194801P | 2001-04-06 | 2001-04-06 | |
US28194601P | 2001-04-06 | 2001-04-06 | |
US60/281,948 | 2001-04-06 | ||
US60/281,946 | 2001-04-06 |
Related Child Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10416418 A-371-Of-International | 2001-11-16 | ||
US10/416,418 A-371-Of-International US7378280B2 (en) | 2000-11-16 | 2001-11-16 | Apparatus and methods for conducting assays and high throughput screening |
US12/127,720 Division US7887753B2 (en) | 2000-11-16 | 2008-05-27 | Apparatus and methods for conducting assays and high throughput screening |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2002040874A1 true WO2002040874A1 (en) | 2002-05-23 |
Family
ID=27400199
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/044869 WO2002040874A1 (en) | 2000-11-16 | 2001-11-16 | Apparatus and methods for conducting assays and high throughput screening |
Country Status (4)
Country | Link |
---|---|
US (7) | US7378280B2 (en) |
EP (2) | EP1343973B2 (en) |
AU (1) | AU2002230524A1 (en) |
WO (1) | WO2002040874A1 (en) |
Cited By (65)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004025128A1 (en) * | 2002-09-10 | 2004-03-25 | Canon Kabushiki Kaisha | Liquid delivery device |
WO2005056813A2 (en) | 2003-12-05 | 2005-06-23 | California Institute Of Technology | Microfluidic protein crystallography techniques |
WO2005121308A1 (en) * | 2004-06-08 | 2005-12-22 | Konica Minolta Medical & Graphic, Inc. | Microreactor enhancing efficiency of liquid mixing and reaction |
EP1664601A2 (en) * | 2003-08-11 | 2006-06-07 | California Institute Of Technology | Microfluidic large scale integration |
EP1670898A2 (en) * | 2003-08-11 | 2006-06-21 | California Institute of Technology | Microfluidic rotary flow reactor matrix |
WO2007041486A2 (en) | 2005-09-29 | 2007-04-12 | Siemens Medical Solutions Usa, Inc. | Microfluidic chip for synthesizing radioactively labeled molecules suitable for human imaging with positron emission tomography |
WO2007064635A1 (en) * | 2005-11-30 | 2007-06-07 | Micronics, Inc. | Microfluidic mixing and analytical apparatus and method for affinity capture of a ligand |
EP1806393A1 (en) * | 2004-10-27 | 2007-07-11 | Konica Minolta Medical & Graphic, Inc. | Microreactor for genetic test |
EP2119503A2 (en) | 2008-05-13 | 2009-11-18 | Commissariat a L'Energie Atomique | Microfluid system and method for sorting clusters of cells and continuously encapsulating them once they are sorted |
US7799277B2 (en) * | 2003-12-08 | 2010-09-21 | Canon Kabushiki Kaisha | Detection device and detection method |
US7815868B1 (en) | 2006-02-28 | 2010-10-19 | Fluidigm Corporation | Microfluidic reaction apparatus for high throughput screening |
US7820427B2 (en) | 2001-11-30 | 2010-10-26 | Fluidigm Corporation | Microfluidic device and methods of using same |
US7829032B2 (en) | 2007-01-23 | 2010-11-09 | Siemens Medical Solutions Usa, Inc. | Fully-automated microfluidic system for the synthesis of radiolabeled biomarkers for positron emission tomography |
US7833708B2 (en) | 2001-04-06 | 2010-11-16 | California Institute Of Technology | Nucleic acid amplification using microfluidic devices |
US7887753B2 (en) | 2000-11-16 | 2011-02-15 | California Institute Of Technology | Apparatus and methods for conducting assays and high throughput screening |
EP2298448A2 (en) * | 2002-09-25 | 2011-03-23 | California Institute of Technology | Microfluidic large scale integration |
EP1549768A4 (en) * | 2002-10-04 | 2011-05-04 | California Inst Of Techn | Microfluidic protein crystallography |
US20110129841A1 (en) * | 2005-06-02 | 2011-06-02 | Fluidigm Corporation | Analysis using microfluidic partitioning devices |
US7955504B1 (en) * | 2004-10-06 | 2011-06-07 | State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University | Microfluidic devices, particularly filtration devices comprising polymeric membranes, and method for their manufacture and use |
US8012680B2 (en) * | 2003-03-24 | 2011-09-06 | Sony Corporation | Microchip, nucleic acid extracting kit, and nucleic acid extracting method |
US8071035B2 (en) | 2007-04-12 | 2011-12-06 | Siemens Medical Solutions Usa, Inc. | Microfluidic radiosynthesis system for positron emission tomography biomarkers |
US8220494B2 (en) | 2002-09-25 | 2012-07-17 | California Institute Of Technology | Microfluidic large scale integration |
GB2495536A (en) * | 2011-10-14 | 2013-04-17 | J R Biomedical Ltd | Bioanalytical device with mixing device |
US8871446B2 (en) | 2002-10-02 | 2014-10-28 | California Institute Of Technology | Microfluidic nucleic acid analysis |
US9056291B2 (en) | 2005-11-30 | 2015-06-16 | Micronics, Inc. | Microfluidic reactor system |
US9138687B2 (en) | 2010-06-07 | 2015-09-22 | Oregon State University | Fluid purification system |
CN105188932A (en) * | 2013-04-30 | 2015-12-23 | 皇家飞利浦有限公司 | Fluidic system for processing a sample fluid |
US9328969B2 (en) | 2011-10-07 | 2016-05-03 | Outset Medical, Inc. | Heat exchange fluid purification for dialysis system |
US9402945B2 (en) | 2014-04-29 | 2016-08-02 | Outset Medical, Inc. | Dialysis system and methods |
US9545469B2 (en) | 2009-12-05 | 2017-01-17 | Outset Medical, Inc. | Dialysis system with ultrafiltration control |
US9840732B2 (en) | 2012-05-21 | 2017-12-12 | Fluidigm Corporation | Single-particle analysis of particle populations |
US9895480B2 (en) | 2010-06-07 | 2018-02-20 | Oregon State University | Dialysis system |
US9926521B2 (en) | 2000-06-27 | 2018-03-27 | Fluidigm Corporation | Microfluidic particle-analysis systems |
US10131934B2 (en) | 2003-04-03 | 2018-11-20 | Fluidigm Corporation | Thermal reaction device and method for using the same |
AU2016222420B2 (en) * | 2012-04-03 | 2019-01-03 | Illumina, Inc. | Integrated Optoelectronic Read Head and Fluidic Cartridge Useful for Nucleic Acid Sequencing |
US10676786B2 (en) | 2003-09-05 | 2020-06-09 | Stokes Bio Ltd. | Microfluidic analysis system |
US10730051B2 (en) | 2006-02-07 | 2020-08-04 | Stokes Bio Ltd. | Liquid bridge and system |
US10967338B2 (en) | 2003-09-05 | 2021-04-06 | Stokes Bio Ltd. | Methods of releasing and analyzing cellular components |
CN113711052A (en) * | 2019-05-17 | 2021-11-26 | 株式会社日立高新技术 | Automatic analyzer |
US11479809B2 (en) | 2011-04-13 | 2022-10-25 | Spatial Transcriptomics Ab | Methods of detecting analytes |
US11479810B1 (en) | 2010-04-05 | 2022-10-25 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
US11534537B2 (en) | 2016-08-19 | 2022-12-27 | Outset Medical, Inc. | Peritoneal dialysis system and methods |
US11560593B2 (en) | 2019-12-23 | 2023-01-24 | 10X Genomics, Inc. | Methods for spatial analysis using RNA-templated ligation |
US11613773B2 (en) | 2015-04-10 | 2023-03-28 | Spatial Transcriptomics Ab | Spatially distinguished, multiplex nucleic acid analysis of biological specimens |
US11618897B2 (en) | 2020-12-21 | 2023-04-04 | 10X Genomics, Inc. | Methods, compositions, and systems for capturing probes and/or barcodes |
US11618918B2 (en) * | 2013-06-25 | 2023-04-04 | Prognosys Biosciences, Inc. | Methods and systems for determining spatial patterns of biological targets in a sample |
US11624063B2 (en) | 2020-06-08 | 2023-04-11 | 10X Genomics, Inc. | Methods of determining a surgical margin and methods of use thereof |
US11624086B2 (en) | 2020-05-22 | 2023-04-11 | 10X Genomics, Inc. | Simultaneous spatio-temporal measurement of gene expression and cellular activity |
US11649485B2 (en) | 2019-01-06 | 2023-05-16 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
US11661626B2 (en) | 2020-06-25 | 2023-05-30 | 10X Genomics, Inc. | Spatial analysis of DNA methylation |
US11702693B2 (en) | 2020-01-21 | 2023-07-18 | 10X Genomics, Inc. | Methods for printing cells and generating arrays of barcoded cells |
US11702698B2 (en) | 2019-11-08 | 2023-07-18 | 10X Genomics, Inc. | Enhancing specificity of analyte binding |
US11732300B2 (en) | 2020-02-05 | 2023-08-22 | 10X Genomics, Inc. | Increasing efficiency of spatial analysis in a biological sample |
US11732299B2 (en) | 2020-01-21 | 2023-08-22 | 10X Genomics, Inc. | Spatial assays with perturbed cells |
US11733238B2 (en) | 2010-04-05 | 2023-08-22 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
US11753673B2 (en) | 2021-09-01 | 2023-09-12 | 10X Genomics, Inc. | Methods, compositions, and kits for blocking a capture probe on a spatial array |
US11761038B1 (en) | 2020-07-06 | 2023-09-19 | 10X Genomics, Inc. | Methods for identifying a location of an RNA in a biological sample |
US11773433B2 (en) | 2020-04-22 | 2023-10-03 | 10X Genomics, Inc. | Methods for spatial analysis using targeted RNA depletion |
US11827935B1 (en) | 2020-11-19 | 2023-11-28 | 10X Genomics, Inc. | Methods for spatial analysis using rolling circle amplification and detection probes |
US11898205B2 (en) | 2020-02-03 | 2024-02-13 | 10X Genomics, Inc. | Increasing capture efficiency of spatial assays |
US11926867B2 (en) | 2019-01-06 | 2024-03-12 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
US11926822B1 (en) | 2020-09-23 | 2024-03-12 | 10X Genomics, Inc. | Three-dimensional spatial analysis |
US11933957B1 (en) | 2018-12-10 | 2024-03-19 | 10X Genomics, Inc. | Imaging system hardware |
US11959130B2 (en) | 2020-05-22 | 2024-04-16 | 10X Genomics, Inc. | Spatial analysis to detect sequence variants |
US11965213B2 (en) | 2019-05-30 | 2024-04-23 | 10X Genomics, Inc. | Methods of detecting spatial heterogeneity of a biological sample |
Families Citing this family (239)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6221654B1 (en) | 1996-09-25 | 2001-04-24 | California Institute Of Technology | Method and apparatus for analysis and sorting of polynucleotides based on size |
US6833242B2 (en) * | 1997-09-23 | 2004-12-21 | California Institute Of Technology | Methods for detecting and sorting polynucleotides based on size |
US7144616B1 (en) | 1999-06-28 | 2006-12-05 | California Institute Of Technology | Microfabricated elastomeric valve and pump systems |
US7459022B2 (en) | 2001-04-06 | 2008-12-02 | California Institute Of Technology | Microfluidic protein crystallography |
US8052792B2 (en) | 2001-04-06 | 2011-11-08 | California Institute Of Technology | Microfluidic protein crystallography techniques |
US7601270B1 (en) * | 1999-06-28 | 2009-10-13 | California Institute Of Technology | Microfabricated elastomeric valve and pump systems |
US7306672B2 (en) | 2001-04-06 | 2007-12-11 | California Institute Of Technology | Microfluidic free interface diffusion techniques |
US8709153B2 (en) | 1999-06-28 | 2014-04-29 | California Institute Of Technology | Microfludic protein crystallography techniques |
WO2001067369A2 (en) * | 2000-03-03 | 2001-09-13 | California Institute Of Technology | Combinatorial array for nucleic acid analysis |
US20050118073A1 (en) | 2003-11-26 | 2005-06-02 | Fluidigm Corporation | Devices and methods for holding microfluidic devices |
US7867763B2 (en) | 2004-01-25 | 2011-01-11 | Fluidigm Corporation | Integrated chip carriers with thermocycler interfaces and methods of using the same |
US7351376B1 (en) | 2000-06-05 | 2008-04-01 | California Institute Of Technology | Integrated active flux microfluidic devices and methods |
AU2001290879A1 (en) | 2000-09-15 | 2002-03-26 | California Institute Of Technology | Microfabricated crossflow devices and methods |
US20020108860A1 (en) * | 2001-01-15 | 2002-08-15 | Staats Sau Lan Tang | Fabrication of polymeric microfluidic devices |
US20050196785A1 (en) * | 2001-03-05 | 2005-09-08 | California Institute Of Technology | Combinational array for nucleic acid analysis |
US7060227B2 (en) * | 2001-08-06 | 2006-06-13 | Sau Lan Tang Staats | Microfluidic devices with raised walls |
US7090003B2 (en) * | 2001-10-19 | 2006-08-15 | Wisconsin Alumni Research Foundation | Method and apparatus for temperature control of a microfluidic device |
US7691333B2 (en) | 2001-11-30 | 2010-04-06 | Fluidigm Corporation | Microfluidic device and methods of using same |
US7312085B2 (en) * | 2002-04-01 | 2007-12-25 | Fluidigm Corporation | Microfluidic particle-analysis systems |
US6806543B2 (en) * | 2002-09-12 | 2004-10-19 | Intel Corporation | Microfluidic apparatus with integrated porous-substrate/sensor for real-time (bio)chemical molecule detection |
JP4346893B2 (en) * | 2002-11-01 | 2009-10-21 | 株式会社日立製作所 | Chemical reactor |
US7419638B2 (en) * | 2003-01-14 | 2008-09-02 | Micronics, Inc. | Microfluidic devices for fluid manipulation and analysis |
US10533998B2 (en) | 2008-07-18 | 2020-01-14 | Bio-Rad Laboratories, Inc. | Enzyme quantification |
GB0307403D0 (en) | 2003-03-31 | 2003-05-07 | Medical Res Council | Selection by compartmentalised screening |
US20060078893A1 (en) | 2004-10-12 | 2006-04-13 | Medical Research Council | Compartmentalised combinatorial chemistry by microfluidic control |
GB0307428D0 (en) | 2003-03-31 | 2003-05-07 | Medical Res Council | Compartmentalised combinatorial chemistry |
US7476363B2 (en) | 2003-04-03 | 2009-01-13 | Fluidigm Corporation | Microfluidic devices and methods of using same |
US8828663B2 (en) | 2005-03-18 | 2014-09-09 | Fluidigm Corporation | Thermal reaction device and method for using the same |
US20050145496A1 (en) * | 2003-04-03 | 2005-07-07 | Federico Goodsaid | Thermal reaction device and method for using the same |
AU2004228678A1 (en) * | 2003-04-03 | 2004-10-21 | Fluidigm Corp. | Microfluidic devices and methods of using same |
WO2004103563A2 (en) | 2003-05-20 | 2004-12-02 | Fluidigm Corporation | Method and system for microfluidic device and imaging thereof |
US20050148064A1 (en) * | 2003-12-29 | 2005-07-07 | Intel Corporation | Microfluid molecular-flow fractionator and bioreactor with integrated active/passive diffusion barrier |
US7407799B2 (en) | 2004-01-16 | 2008-08-05 | California Institute Of Technology | Microfluidic chemostat |
US20050221339A1 (en) | 2004-03-31 | 2005-10-06 | Medical Research Council Harvard University | Compartmentalised screening by microfluidic control |
CN102680440A (en) | 2004-06-07 | 2012-09-19 | 先锋生物科技股份有限公司 | Optical lens system and method for microfluidic devices |
US8262909B2 (en) * | 2004-07-06 | 2012-09-11 | Schlumberger Technology Corporation | Methods and devices for minimizing membrane fouling for microfluidic separators |
US7575681B2 (en) * | 2004-07-06 | 2009-08-18 | Schlumberger Technology Corporation | Microfluidic separator |
US20060073035A1 (en) * | 2004-09-30 | 2006-04-06 | Narayan Sundararajan | Deformable polymer membranes |
US7968287B2 (en) | 2004-10-08 | 2011-06-28 | Medical Research Council Harvard University | In vitro evolution in microfluidic systems |
US7585664B2 (en) * | 2004-10-14 | 2009-09-08 | The Hong Kong University Of Science And Technology | Integrated circuit optical detector for biological detection |
US7361315B2 (en) | 2004-10-26 | 2008-04-22 | Konica Minolta Medical & Graphic, Inc. | Micro-reactor for biological substance inspection and biological substance inspection device |
US20080264863A1 (en) * | 2004-12-03 | 2008-10-30 | California Institute Of Technology | Microfluidic Sieve Valves |
JP2008522795A (en) * | 2004-12-03 | 2008-07-03 | カリフォルニア インスティチュート オブ テクノロジー | Microfluidic device with chemical reaction circuit |
WO2006083833A2 (en) | 2005-01-31 | 2006-08-10 | President And Fellows Of Harvard College | Valves and reservoirs for microfluidic systems |
WO2006089192A2 (en) * | 2005-02-18 | 2006-08-24 | Canon U.S. Life Sciences, Inc. | Devices and methods for identifying genomic dna of organisms |
JP4548174B2 (en) * | 2005-03-24 | 2010-09-22 | コニカミノルタエムジー株式会社 | Microchip for inspection and inspection apparatus using the same |
DE102005018337A1 (en) * | 2005-04-20 | 2006-11-02 | Micronas Gmbh | Micro-optical detection system and method for determining temperature-dependent parameters of analytes |
WO2006127191A2 (en) | 2005-04-20 | 2006-11-30 | Fluidigm Corporation | Analysis engine and database for manipulating parameters for fluidic systems on a chip |
US7320338B2 (en) * | 2005-06-03 | 2008-01-22 | Honeywell International Inc. | Microvalve package assembly |
WO2007019479A2 (en) * | 2005-08-04 | 2007-02-15 | Helicos Biosciences Corporation | Multi-channel flow cells |
US20070054293A1 (en) * | 2005-08-30 | 2007-03-08 | California Institute Of Technology | Microfluidic chaotic mixing systems and methods |
EP1938101A2 (en) * | 2005-09-13 | 2008-07-02 | Fluidigm Corporation | Microfluidic assay devices and methods |
JP2007121275A (en) * | 2005-09-27 | 2007-05-17 | Fujifilm Corp | Microchip and liquid mixing method and blood testing method using microchip |
US7790028B1 (en) * | 2005-09-28 | 2010-09-07 | The Charles Stark Draper Laboratory, Inc. | Systems, methods, and devices relating to a cellularized nephron unit |
US20090221082A1 (en) * | 2005-10-06 | 2009-09-03 | Rhodia Operations | Microfluidic Evaporators And Determining Physical And/Or Chemical Properties Of Chemical Compounds Therewith |
WO2007044888A2 (en) * | 2005-10-11 | 2007-04-19 | The Johns Hopkins Univerisity | Microfluidic device and method for high-throughput cellular gradient and dose response studies |
WO2007044856A1 (en) * | 2005-10-11 | 2007-04-19 | The Johns Hopkins University | Device and method for high-throughput stimulation, immunostaining, and visualization of single cells |
US9206396B2 (en) * | 2005-11-16 | 2015-12-08 | Wisconsin Alumni Research Foundation | Methods and devices for quantitative viral assays |
WO2007081386A2 (en) * | 2006-01-11 | 2007-07-19 | Raindance Technologies, Inc. | Microfluidic devices and methods of use |
WO2007121263A2 (en) * | 2006-04-14 | 2007-10-25 | Wako Pure Chemical Industries, Ltd | Structure for introducing a plurality of solutions, micro fluidic device having said structure and method for introducing solution |
US8828661B2 (en) | 2006-04-24 | 2014-09-09 | Fluidigm Corporation | Methods for detection and quantification of nucleic acid or protein targets in a sample |
RU2386138C1 (en) * | 2006-04-25 | 2010-04-10 | Панасоник Корпорэйшн | Immunoassay and chip |
US9562837B2 (en) | 2006-05-11 | 2017-02-07 | Raindance Technologies, Inc. | Systems for handling microfludic droplets |
US20080014589A1 (en) | 2006-05-11 | 2008-01-17 | Link Darren R | Microfluidic devices and methods of use thereof |
JP2007301534A (en) * | 2006-05-15 | 2007-11-22 | Ebara Corp | Atomizer |
US7629124B2 (en) * | 2006-06-30 | 2009-12-08 | Canon U.S. Life Sciences, Inc. | Real-time PCR in micro-channels |
EP2077912B1 (en) | 2006-08-07 | 2019-03-27 | The President and Fellows of Harvard College | Fluorocarbon emulsion stabilizing surfactants |
US8055034B2 (en) | 2006-09-13 | 2011-11-08 | Fluidigm Corporation | Methods and systems for image processing of microfluidic devices |
US10753927B2 (en) | 2006-09-22 | 2020-08-25 | ALERE TECHNOLOGIES GmbH | Methods for detecting an analyte |
WO2008135564A2 (en) * | 2007-05-03 | 2008-11-13 | Clondiag Gmbh | Assays |
FR2907228B1 (en) * | 2006-10-13 | 2009-07-24 | Rhodia Recherches & Tech | FLUID FLOW DEVICE, ASSEMBLY FOR DETERMINING AT LEAST ONE CHARACTERISTIC OF A PHYSICO-CHEMICAL SYSTEM COMPRISING SUCH A DEVICE, DETERMINING METHOD AND CORRESPONDING SCREENING METHOD |
WO2008067552A2 (en) * | 2006-11-30 | 2008-06-05 | Fluidigm Corporation | Method and apparatus for biological sample analysis |
WO2008089493A2 (en) | 2007-01-19 | 2008-07-24 | Fluidigm Corporation | High precision microfluidic devices and methods |
US8772046B2 (en) | 2007-02-06 | 2014-07-08 | Brandeis University | Manipulation of fluids and reactions in microfluidic systems |
US20100151465A1 (en) | 2008-03-27 | 2010-06-17 | Jingyue Ju | Selective Capture and Release of Analytes |
US8592221B2 (en) | 2007-04-19 | 2013-11-26 | Brandeis University | Manipulation of fluids, fluid components and reactions in microfluidic systems |
EP2181328A4 (en) * | 2007-08-10 | 2010-07-21 | Carnegie Inst Of Washington | Methods of using ret nanosensors |
WO2009033178A1 (en) | 2007-09-07 | 2009-03-12 | Fluidigm Corporation | Copy number variation determination, methods and systems |
WO2009039433A1 (en) * | 2007-09-20 | 2009-03-26 | Incept Biosystems Inc. | Analytical microfluidic culture system |
CA2700946A1 (en) * | 2007-09-28 | 2009-04-02 | University Of Toronto | A system, apparatus and method for applying mechanical force to a material |
US9267918B2 (en) | 2007-10-16 | 2016-02-23 | Cambridge Enterprise Limited | Microfluidic systems |
GB0720202D0 (en) | 2007-10-16 | 2007-11-28 | Cambridge Entpr Ltd | Microfluidic systems |
JP2009133818A (en) * | 2007-11-05 | 2009-06-18 | Sony Corp | Method and device for feeding liquid in substrate channel |
US20090117664A1 (en) * | 2007-11-05 | 2009-05-07 | Masataka Shinoda | Liquid sending method of liquid in substrate channel and liquid sending apparatus |
US20100279309A1 (en) * | 2007-11-19 | 2010-11-04 | Florida Atlantic University | Microfluidic chips and systems for analyzing protein expression, and methods of use thereof |
JP2011512125A (en) * | 2008-02-01 | 2011-04-21 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | Microfluidic image cytometry |
US9157116B2 (en) | 2008-02-08 | 2015-10-13 | Fluidigm Corporation | Combinatorial amplification and detection of nucleic acids |
US8173080B2 (en) | 2008-02-14 | 2012-05-08 | Illumina, Inc. | Flow cells and manifolds having an electroosmotic pump |
US20090211977A1 (en) * | 2008-02-27 | 2009-08-27 | Oregon State University | Through-plate microchannel transfer devices |
EP3636341B1 (en) * | 2008-03-14 | 2021-12-08 | Abbott Rapid Diagnostics Jena GmbH | Assays and devices |
EP2280905B1 (en) | 2008-04-11 | 2016-07-06 | Fluidigm Corporation | Multilevel microfluidic systems and methods |
CA2764611C (en) | 2008-06-05 | 2017-11-21 | The Administrators Of The Tulane Educational Fund | Methods and instrumentation for during-synthesis monitoring of polymer functional evolution |
WO2010009365A1 (en) | 2008-07-18 | 2010-01-21 | Raindance Technologies, Inc. | Droplet libraries |
CN104043490A (en) | 2008-07-25 | 2014-09-17 | 弗卢丁公司 | Method and system for manufacturing integrated fluidic chips |
WO2010017210A1 (en) | 2008-08-07 | 2010-02-11 | Fluidigm Corporation | Microfluidic mixing and reaction systems for high efficiency screening |
JP4722977B2 (en) * | 2008-08-27 | 2011-07-13 | シャープ株式会社 | Detection instrument, analyzer, detection method, and control method of detection instrument |
US9540686B2 (en) * | 2008-09-18 | 2017-01-10 | Canon U.S. Life Sciences, Inc. | Systems and methods for the amplification of DNA |
DE102008048064A1 (en) * | 2008-09-19 | 2010-04-08 | Jobst Technologies Gmbh | Microfluidic valve, microfluidic pump, microfluidic system and a manufacturing process |
WO2010040103A1 (en) | 2008-10-03 | 2010-04-08 | Micronics, Inc. | Microfluidic apparatus and methods for performing blood typing and crossmatching |
US8217478B2 (en) * | 2008-10-10 | 2012-07-10 | Seagate Technology Llc | Magnetic stack with oxide to reduce switching current |
US8309306B2 (en) * | 2008-11-12 | 2012-11-13 | Nodality, Inc. | Detection composition |
CN102308090B (en) | 2008-11-26 | 2015-12-02 | 伊路敏纳公司 | There is the electroosmotic pump of the gas delivery of improvement |
EA020593B1 (en) * | 2009-01-13 | 2014-12-30 | Флуидигм Корпорейшн | Single-cell nucleic acid analysis |
US8058630B2 (en) * | 2009-01-16 | 2011-11-15 | Fluidigm Corporation | Microfluidic devices and methods |
TWI400446B (en) * | 2009-03-20 | 2013-07-01 | Univ Nat Cheng Kung | Immuno-analysis biochip |
US8528589B2 (en) | 2009-03-23 | 2013-09-10 | Raindance Technologies, Inc. | Manipulation of microfluidic droplets |
CN103952482A (en) | 2009-04-02 | 2014-07-30 | 弗卢伊蒂格姆公司 | Multi-primer amplification method for barcoding of target nucleic acids |
US9090663B2 (en) * | 2009-04-21 | 2015-07-28 | The Trustees Of Columbia University In The City Of New York | Systems and methods for the capture and separation of microparticles |
JP2012531256A (en) * | 2009-06-24 | 2012-12-10 | ステイト オブ オレゴン アクティング バイ アンド スルー ザ ステイト ボード オブ ハイヤー エデュケーション オン ビハーフ オブ オレゴン ステイト ユニバーシティー | Microfluidic device for dialysis |
CN101614655B (en) * | 2009-07-16 | 2010-11-10 | 江西科技师范学院 | Detection method of microfluidic chip based on photoacoustic technique and device thereof |
WO2011011669A1 (en) * | 2009-07-23 | 2011-01-27 | University Of Wyoming | Methods and compositions for detection of biological materials using microfluidic devices |
US8551787B2 (en) * | 2009-07-23 | 2013-10-08 | Fluidigm Corporation | Microfluidic devices and methods for binary mixing |
EP2292329B1 (en) * | 2009-09-08 | 2014-11-12 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Polymer substrate with fluorescent structure, method for production of same and application of same |
SG169918A1 (en) | 2009-10-02 | 2011-04-29 | Fluidigm Corp | Microfluidic devices with removable cover and methods of fabrication and application |
EP2486409A1 (en) | 2009-10-09 | 2012-08-15 | Universite De Strasbourg | Labelled silica-based nanomaterial with enhanced properties and uses thereof |
CN106730084A (en) * | 2009-10-29 | 2017-05-31 | 查尔斯斯塔克德雷珀实验室公司 | For the microfluidic device of haemodialysis |
US20110143378A1 (en) * | 2009-11-12 | 2011-06-16 | CyVek LLC. | Microfluidic method and apparatus for high performance biological assays |
DE102009055023B4 (en) * | 2009-11-19 | 2011-09-22 | Vereta Gmbh | Device for measuring the mass concentration of fine dust present in the exhaust gas of solid fuel combustion devices |
US9500645B2 (en) | 2009-11-23 | 2016-11-22 | Cyvek, Inc. | Micro-tube particles for microfluidic assays and methods of manufacture |
JP5701894B2 (en) | 2009-11-23 | 2015-04-15 | サイヴェク・インコーポレイテッド | Method and apparatus for performing an assay |
US9759718B2 (en) | 2009-11-23 | 2017-09-12 | Cyvek, Inc. | PDMS membrane-confined nucleic acid and antibody/antigen-functionalized microlength tube capture elements, and systems employing them, and methods of their use |
US10065403B2 (en) | 2009-11-23 | 2018-09-04 | Cyvek, Inc. | Microfluidic assay assemblies and methods of manufacture |
US9855735B2 (en) | 2009-11-23 | 2018-01-02 | Cyvek, Inc. | Portable microfluidic assay devices and methods of manufacture and use |
US9651568B2 (en) | 2009-11-23 | 2017-05-16 | Cyvek, Inc. | Methods and systems for epi-fluorescent monitoring and scanning for microfluidic assays |
US9700889B2 (en) | 2009-11-23 | 2017-07-11 | Cyvek, Inc. | Methods and systems for manufacture of microarray assay systems, conducting microfluidic assays, and monitoring and scanning to obtain microfluidic assay results |
EP2506882A4 (en) | 2009-11-30 | 2017-05-17 | Fluidigm Corporation | Microfluidic device regeneration |
US20110189048A1 (en) * | 2009-12-05 | 2011-08-04 | Curtis James R | Modular dialysis system |
US10837883B2 (en) | 2009-12-23 | 2020-11-17 | Bio-Rad Laboratories, Inc. | Microfluidic systems and methods for reducing the exchange of molecules between droplets |
US10351905B2 (en) | 2010-02-12 | 2019-07-16 | Bio-Rad Laboratories, Inc. | Digital analyte analysis |
US9366632B2 (en) | 2010-02-12 | 2016-06-14 | Raindance Technologies, Inc. | Digital analyte analysis |
US9399797B2 (en) | 2010-02-12 | 2016-07-26 | Raindance Technologies, Inc. | Digital analyte analysis |
WO2011100604A2 (en) | 2010-02-12 | 2011-08-18 | Raindance Technologies, Inc. | Digital analyte analysis |
EP3239717B1 (en) * | 2010-04-15 | 2020-05-27 | Accellix Ltd | System and method for determination of a medical condition |
US8867803B2 (en) * | 2010-04-20 | 2014-10-21 | Eric J. Seibel | Optical projection tomography microscopy (OPTM) for large specimen sizes |
US8475738B2 (en) * | 2010-05-04 | 2013-07-02 | Electronics And Telecommunications Research Institute | Photocatalytic apparatus and method for injecting microfluidic volumes |
US9101573B2 (en) | 2010-05-04 | 2015-08-11 | Virginia Tech Intellectual Properties, Inc. | Lanthionine synthetase component C-like proteins as molecular targets for preventing and treating diseases and disorders |
US8580161B2 (en) | 2010-05-04 | 2013-11-12 | State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University | Fluidic devices comprising photocontrollable units |
US20110312709A1 (en) * | 2010-06-17 | 2011-12-22 | Geneasys Pty Ltd | Loc device for detecting target nucleic acid sequences using electrochemiluminescent probes and calibration probes with detection photosensors and calibration photosensors |
GB2481425A (en) | 2010-06-23 | 2011-12-28 | Iti Scotland Ltd | Method and device for assembling polynucleic acid sequences |
WO2012002497A1 (en) * | 2010-07-01 | 2012-01-05 | 株式会社カネカ | Disposable set for cell culture, cell culture device and cell preparation method |
WO2012037061A2 (en) * | 2010-09-13 | 2012-03-22 | California Institute Of Technology | Handheld low pressure mechanical cell lysis device with single cell resolution |
US20140291155A1 (en) * | 2010-09-23 | 2014-10-02 | Battelle Memorial Institute | Microfluidic Sample Injectors Absent Electrokinetic Injection |
US8277659B2 (en) * | 2010-09-23 | 2012-10-02 | Battelle Memorial Institute | Microchip capillary electrophoresis absent electrokinetic injection |
US20160084805A1 (en) * | 2010-09-23 | 2016-03-24 | Battelle Memorial Institute | System and method of preconcentrating analytes in a microfluidic device |
EP3447155A1 (en) | 2010-09-30 | 2019-02-27 | Raindance Technologies, Inc. | Sandwich assays in droplets |
WO2012054933A2 (en) | 2010-10-22 | 2012-04-26 | Fluidigm Corporation | Universal probe assay methods |
KR101776215B1 (en) * | 2010-10-29 | 2017-09-08 | 삼성전자 주식회사 | Micro-device for disrupting cells and method of disrupting cells using the same |
US8871500B2 (en) * | 2011-01-21 | 2014-10-28 | Innovative Micro Technology | MEMS particle sorting actuator and method of manufacturing |
WO2012106385A2 (en) | 2011-01-31 | 2012-08-09 | Apprise Bio, Inc. | Methods of identifying multiple epitopes in cells |
WO2012109600A2 (en) | 2011-02-11 | 2012-08-16 | Raindance Technologies, Inc. | Methods for forming mixed droplets |
WO2012112804A1 (en) | 2011-02-18 | 2012-08-23 | Raindance Technoligies, Inc. | Compositions and methods for molecular labeling |
CN106552682B (en) | 2011-03-22 | 2020-06-19 | 西维克公司 | Microfluidic device and methods of manufacture and use |
US9168531B2 (en) | 2011-03-24 | 2015-10-27 | Fluidigm Corporation | Method for thermal cycling of microfluidic samples |
WO2012154876A1 (en) | 2011-05-09 | 2012-11-15 | Fluidigm Corporation | Probe based nucleic acid detection |
US9644231B2 (en) | 2011-05-09 | 2017-05-09 | Fluidigm Corporation | Nucleic acid detection using probes |
US8841071B2 (en) | 2011-06-02 | 2014-09-23 | Raindance Technologies, Inc. | Sample multiplexing |
JP6041872B2 (en) | 2011-06-15 | 2016-12-14 | ザ チャールズ スターク ドレイパー ラボラトリー インク | Bioartificial kidney |
US8658430B2 (en) | 2011-07-20 | 2014-02-25 | Raindance Technologies, Inc. | Manipulating droplet size |
WO2013019714A1 (en) | 2011-07-29 | 2013-02-07 | The Trustees Of Columbia University In The City Of New York | Mems affinity sensor for continuous monitoring of analytes |
TW201326814A (en) * | 2011-12-21 | 2013-07-01 | Nat Univ Tsing Hua | Microfluidic chip device for selecting a cell aptamer and method thereof |
KR101244285B1 (en) * | 2011-12-21 | 2013-03-18 | 충남대학교산학협력단 | Micro fluidic chip for droplet generation, micro fluidic chip for droplet-based reaction and appatatus for analysis of reaction in multi-droplets |
WO2013095867A1 (en) * | 2011-12-21 | 2013-06-27 | Becton, Dickinson And Company | Flow cytometric systems for sterile separation of magnetically labeled sample components |
DE102012201018B4 (en) * | 2012-01-24 | 2016-03-31 | Ifm Electronic Gmbh | Measuring instrument with air passage provided on the housing |
US9304065B2 (en) | 2012-02-29 | 2016-04-05 | Fluidigm Corporation | Methods, systems and devices for multiple single-cell capturing and processing using microfluidics |
KR102114734B1 (en) | 2012-03-08 | 2020-05-25 | 싸이벡, 아이엔씨 | Micro-tube particles for microfluidic assays and methods of manufacture |
WO2013151126A1 (en) | 2012-04-06 | 2013-10-10 | 株式会社フジクラ | Fluid control device and fluid mixer |
EP3578669A1 (en) | 2012-08-08 | 2019-12-11 | F. Hoffmann-La Roche AG | Increasing dynamic range for identifying multiple epitopes in cells |
US9580679B2 (en) | 2012-09-21 | 2017-02-28 | California Institute Of Technology | Methods and devices for sample lysis |
US9518914B2 (en) | 2012-09-24 | 2016-12-13 | Brigham And Women's Hospital, Inc. | Portal and method for management of dialysis therapy |
US9518977B2 (en) | 2012-10-19 | 2016-12-13 | University Of Washington Through Its Center For Commercialization | Microfluidic assay apparatus and methods of use |
US9233225B2 (en) | 2012-11-10 | 2016-01-12 | Curvo Medical, Inc. | Coaxial bi-directional catheter |
US9549666B2 (en) | 2012-11-10 | 2017-01-24 | Curvo Medical, Inc. | Coaxial micro-endoscope |
US10724986B2 (en) * | 2012-11-29 | 2020-07-28 | Indiana University Research & Technology Corporation | Dielectric electrolyte measurement device |
EP2932268A4 (en) | 2012-12-17 | 2016-10-19 | Leukodx Ltd | Systems and methods for detecting a biological condition |
US20140170678A1 (en) | 2012-12-17 | 2014-06-19 | Leukodx Ltd. | Kits, compositions and methods for detecting a biological condition |
US10610861B2 (en) | 2012-12-17 | 2020-04-07 | Accellix Ltd. | Systems, compositions and methods for detecting a biological condition |
JP2016521350A (en) | 2013-03-15 | 2016-07-21 | フリューダイム・コーポレイション | Method and apparatus for analysis of defined multicellular combinations |
EP3462174B1 (en) * | 2013-03-15 | 2021-12-29 | Arizona Board of Regents on behalf of Arizona State University | Biosensor microarray compositions and methods |
US20140326400A1 (en) * | 2013-05-01 | 2014-11-06 | Ismail Emre ARACI | Robust monolithic micromechanical valves for high density microfluidic very large scale integration |
WO2014182844A1 (en) | 2013-05-07 | 2014-11-13 | Micronics, Inc. | Microfluidic devices and methods for performing serum separation and blood cross-matching |
ITTO20130447A1 (en) * | 2013-05-31 | 2014-12-01 | St Microelectronics Srl | MICROFLUID MEMBRANE VALVE AND PROCEDURE FOR MANUFACTURING A MEMBRANE MICROFLUID VALVE |
EP3024582A4 (en) | 2013-07-22 | 2017-03-08 | President and Fellows of Harvard College | Microfluidic cartridge assembly |
US9618450B2 (en) * | 2013-09-27 | 2017-04-11 | Ecolab USA, Inc. | Multi-channel fluorometric sensor and method of using same |
US11901041B2 (en) | 2013-10-04 | 2024-02-13 | Bio-Rad Laboratories, Inc. | Digital analysis of nucleic acid modification |
CA2866542A1 (en) * | 2013-10-08 | 2015-04-08 | Ponnambalam Selvaganapathy | Integrated reagentless sample preprocessing for molecular diagnostics using a nanoporous membrane based microfluidic device |
DK3060912T3 (en) * | 2013-10-22 | 2020-09-28 | Berkeley Lights Inc | PROCEDURE AND MICROFLUID DEVICE FOR ANALYSIS OF BIOLOGICAL ACTIVITY |
US9889445B2 (en) | 2013-10-22 | 2018-02-13 | Berkeley Lights, Inc. | Micro-fluidic devices for assaying biological activity |
CN105873681B (en) | 2013-11-18 | 2019-10-11 | 尹特根埃克斯有限公司 | Cartridge and instrument for sample analysis |
US9944977B2 (en) | 2013-12-12 | 2018-04-17 | Raindance Technologies, Inc. | Distinguishing rare variations in a nucleic acid sequence from a sample |
EP3090063B1 (en) | 2013-12-31 | 2019-11-06 | Bio-Rad Laboratories, Inc. | Method for detection of latent retrovirus |
WO2015179098A1 (en) | 2014-05-21 | 2015-11-26 | Integenx Inc. | Fluidic cartridge with valve mechanism |
KR102195769B1 (en) * | 2014-07-10 | 2020-12-30 | 주식회사 미코바이오메드 | Microfludic chip, manufacturing method thereof and analyzing apparatus using the same |
WO2016022696A1 (en) | 2014-08-05 | 2016-02-11 | The Trustees Of Columbia University In The City Of New York | Method of isolating aptamers for minimal residual disease detection |
US10266397B2 (en) * | 2014-08-13 | 2019-04-23 | University Of South Carolina | III-V nitride resonate structure based photoacoustic sensor |
US11835500B2 (en) | 2014-10-13 | 2023-12-05 | The Administrators Of The Tulane Educational Fund | Device and method for changing solution conditions in serial flow |
FR3028038B1 (en) * | 2014-10-31 | 2018-01-12 | Commissariat A L'energie Atomique Et Aux Energies Alternatives | METHOD AND SYSTEM FOR ESTIMATING A CONCENTRATION OF A SPECIES IN A LENTILESS IMAGING CULTURE MEDIUM |
WO2016145050A1 (en) | 2015-03-10 | 2016-09-15 | Carbon3D, Inc. | Microfluidic devices having flexible features and methods of making the same |
US10751715B1 (en) * | 2015-04-22 | 2020-08-25 | Berkeley Lights, Inc. | Microfluidic reporter cell assay methods and kits thereof |
US10233491B2 (en) | 2015-06-19 | 2019-03-19 | IntegenX, Inc. | Valved cartridge and system |
US10647981B1 (en) | 2015-09-08 | 2020-05-12 | Bio-Rad Laboratories, Inc. | Nucleic acid library generation methods and compositions |
US11235320B2 (en) * | 2015-10-08 | 2022-02-01 | International Business Machines Corporation | Self-tuning system for manipulating complex fluids using electrokinectics |
EP3367105A4 (en) * | 2015-10-23 | 2019-05-15 | Japan Science and Technology Agency | Nano-fluid device and chemical analysis apparatus |
KR20180085783A (en) | 2015-11-23 | 2018-07-27 | 버클리 라잇츠, 인크. | In situ-generated microfluidic isolation structures, kits, and methods of use thereof |
US10228367B2 (en) | 2015-12-01 | 2019-03-12 | ProteinSimple | Segmented multi-use automated assay cartridge |
CA3005077C (en) * | 2015-12-08 | 2023-02-28 | Berkeley Lights, Inc. | In situ-generated microfluidic assay structures, related kits, and methods of use thereof |
US10444184B2 (en) | 2015-12-28 | 2019-10-15 | International Business Machines Corporation | Operation of diagnostic devices involving microchannels and electrodes |
US10890546B2 (en) | 2016-03-09 | 2021-01-12 | The Regents Of The University Of California | Transient induced molecular electronic spectroscopy method for study of molecule interactions |
AU2017249049A1 (en) | 2016-04-15 | 2018-10-25 | Becton, Dickinson And Company | Enclosed droplet sorter and methods of using the same |
US11872559B2 (en) | 2016-09-14 | 2024-01-16 | Ecole Polytechnique Federale De Lausanne (Epfl) | Device for high throughput single-cell studies |
US10816456B2 (en) | 2016-10-19 | 2020-10-27 | International Business Machines Corporation | Systems and methods for reconfigurable point-of-care diagnostics |
US11226278B2 (en) | 2016-11-08 | 2022-01-18 | Kennesaw State University Research And Service Foundation, Inc. | Leukocyte quantitation microfluidic method and device |
EP3541505A4 (en) * | 2016-11-18 | 2020-01-01 | The Regents of The University of California | Microscale device and method for purification of radiopharmaceuticals |
US20200149086A1 (en) * | 2016-12-23 | 2020-05-14 | SeLux Diagnostics, Inc. | Methods for improved rapid antimicrobial susceptibility testing |
CN106770376B (en) * | 2017-02-15 | 2023-04-07 | 河南师范大学 | Biosensor based on radio frequency technology |
WO2018183126A1 (en) * | 2017-03-28 | 2018-10-04 | Redbud Labs | System, fluidics cartridge, and methods for using actuated surface-attached posts for processing cells |
CN109012768B (en) * | 2017-06-09 | 2021-11-19 | 国家纳米科学中心 | Microfluidic liquid one-way flow control structure, chip and method |
US11634676B2 (en) * | 2017-07-18 | 2023-04-25 | President And Fellows Of Harvard College | Intracellular delivery using microfluidics-assisted cell screening (MACS) |
CN111050913B (en) * | 2017-09-01 | 2022-04-12 | 深圳华大智造科技有限公司 | Injection molded microfluidic/fluidic cartridge integrated with silicon-based sensors |
US10344929B1 (en) | 2017-09-01 | 2019-07-09 | Heathco, Llc | Battery backup for lighting system |
US11185830B2 (en) | 2017-09-06 | 2021-11-30 | Waters Technologies Corporation | Fluid mixer |
KR20190035241A (en) * | 2017-09-26 | 2019-04-03 | 삼성전자주식회사 | Method of controlling a temperature of a chemical mechanical polishing (cmp) process, temperature control unit for performing the method, and cmp apparatus including the temperature control unit |
US11402376B2 (en) | 2018-03-23 | 2022-08-02 | University Of Wyoming | Methods and devices for detection of biological materials using electric field assisted rapid analyte capture |
CN111989158B (en) * | 2018-04-15 | 2022-08-12 | 奥普图弗卢迪克生物鉴定有限责任公司 | Pressure differential auxiliary drainage system |
US11752500B2 (en) | 2018-04-27 | 2023-09-12 | Corning Incorporated | Microfluidic devices and methods for manufacturing microfluidic devices |
US11275075B2 (en) | 2018-04-27 | 2022-03-15 | Becton, Dickinson And Company | Collection systems for flow cytometrically sorted samples and methods of using the same |
EP3785015A4 (en) | 2018-04-27 | 2022-01-19 | Becton, Dickinson and Company | Flow cytometers having enclosed droplet sorters with controlled aerosol content and methods of using the same |
WO2019241794A1 (en) * | 2018-06-16 | 2019-12-19 | Hacker Kevin Jay | Microorganism identification and characterization |
US11035776B2 (en) | 2018-10-30 | 2021-06-15 | Becton, Dickinson And Company | Particle sorting module with alignment window, systems and methods of use thereof |
CN110007069B (en) * | 2019-03-05 | 2022-11-11 | 深圳迎凯生物科技有限公司 | Fluorescence immunity tester |
GB2582619A (en) * | 2019-03-28 | 2020-09-30 | Sumitomo Chemical Co | Enzyme linked assay methods and apparatuses |
CN110308674A (en) * | 2019-05-28 | 2019-10-08 | 云南农业大学 | The measurement method of moisture penetration rule in a kind of mountain plateau red soil |
WO2021030245A1 (en) | 2019-08-12 | 2021-02-18 | Waters Technologies Corporation | Mixer for chromatography system |
US11959057B2 (en) | 2019-10-17 | 2024-04-16 | New Jersey Institute Of Technology | Automated addressable microfluidic technology for minimally disruptive manipulation of cells and fluids within living cultures |
WO2022010665A1 (en) | 2020-07-07 | 2022-01-13 | Waters Technologies Corporation | Mixer for liquid chromatography |
AU2021341824A1 (en) | 2020-09-08 | 2023-03-23 | Sunflower Therapeutics, Llc | Fluid transport and distribution manifold |
WO2022066752A1 (en) | 2020-09-22 | 2022-03-31 | Waters Technologies Corporation | Continuous flow mixer |
US11872357B2 (en) | 2020-11-09 | 2024-01-16 | Agile Devices, Inc. | Devices for steering catheters |
DE102022111381A1 (en) | 2022-03-09 | 2023-09-14 | Hnp Mikrosysteme Gmbh | Fluidic element, fluidic system and method for operating a fluidic system |
CN115445680B (en) * | 2022-11-11 | 2023-03-24 | 杭州毫厘科技有限公司 | Micro-fluidic valve and micro-fluidic device |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5922591A (en) * | 1995-06-29 | 1999-07-13 | Affymetrix, Inc. | Integrated nucleic acid diagnostic device |
US5958344A (en) | 1995-11-09 | 1999-09-28 | Sarnoff Corporation | System for liquid distribution |
US6167910B1 (en) * | 1998-01-20 | 2001-01-02 | Caliper Technologies Corp. | Multi-layer microfluidic devices |
US6235471B1 (en) * | 1997-04-04 | 2001-05-22 | Caliper Technologies Corp. | Closed-loop biochemical analyzers |
US6306659B1 (en) * | 1996-06-28 | 2001-10-23 | Caliper Technologies Corp. | High throughput screening assay systems in microscale fluidic devices |
Family Cites Families (274)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL6711928A (en) † | 1967-08-30 | 1969-03-04 | ||
US3570515A (en) | 1969-06-19 | 1971-03-16 | Foxboro Co | Aminar stream cross-flow fluid diffusion logic gate |
NL7102074A (en) | 1971-02-17 | 1972-08-21 | ||
US4022876A (en) | 1973-06-21 | 1977-05-10 | Stanford Research Institute | Mass spectrometric immunoassay |
FR2287606A1 (en) | 1974-10-08 | 1976-05-07 | Pegourie Jean Pierre | PNEUMATIC LOGIC CIRCUITS AND THEIR INTEGRATED CIRCUITS |
JPS5941169B2 (en) | 1975-12-25 | 1984-10-05 | シチズン時計株式会社 | Elastomer |
US4119120A (en) † | 1976-11-29 | 1978-10-10 | Beckman Instruments, Inc. | Fluid switch |
US4153855A (en) | 1977-12-16 | 1979-05-08 | The United States Of America As Represented By The Secretary Of The Army | Method of making a plate having a pattern of microchannels |
US4245673A (en) | 1978-03-01 | 1981-01-20 | La Telemechanique Electrique | Pneumatic logic circuit |
US4344064A (en) | 1979-12-06 | 1982-08-10 | Western Electric Co., Inc. | Article carrying a distinctive mark |
US4434704A (en) | 1980-04-14 | 1984-03-06 | Halliburton Company | Hydraulic digital stepper actuator |
FR2504010B1 (en) | 1981-04-15 | 1985-10-25 | Sanofi Sa | ANTI-CANCER MEDICINAL PRODUCTS CONTAINING THE RICIN-ASSOCIATED CHAIN ASSOCIATED WITH ANTIMELANOMA ANTIBODY AND PROCESS FOR THEIR PREPARATION |
US4454233A (en) | 1981-10-21 | 1984-06-12 | Wang Associates | Method of tagged immunoassay |
US4671958A (en) | 1982-03-09 | 1987-06-09 | Cytogen Corporation | Antibody conjugates for the delivery of compounds to target sites |
DE3377484D1 (en) | 1982-04-19 | 1988-09-01 | Nissan Motor | Method for controlling reduction ratio of continuously variable transmission with acceleration compensation |
IL68507A (en) * | 1982-05-10 | 1986-01-31 | Univ Bar Ilan | System and methods for cell selection |
US4707237A (en) | 1982-09-09 | 1987-11-17 | Ciba Corning Diagnostics Corp. | System for identification of cells by electrophoresis |
US4479762A (en) † | 1982-12-28 | 1984-10-30 | Baxter Travenol Laboratories, Inc. | Prepackaged fluid processing module having pump and valve elements operable in response to applied pressures |
US4568649A (en) | 1983-02-22 | 1986-02-04 | Immunex Corporation | Immediate ligand detection assay |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US4581624A (en) | 1984-03-01 | 1986-04-08 | Allied Corporation | Microminiature semiconductor valve |
US4542225A (en) | 1984-08-29 | 1985-09-17 | Dana-Farber Cancer Institute, Inc. | Acid-cleavable compound |
US4659839A (en) | 1984-10-10 | 1987-04-21 | Mallinckrodt, Inc. | Coupling agents for radiolabeled antibody fragments |
ATE66469T1 (en) | 1985-01-14 | 1991-09-15 | Neorx Corp | METAL RADIONUCLIDE LABELED PROTEIN FOR DIAGNOSIS AND THERAPY. |
US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
US4680338A (en) | 1985-10-17 | 1987-07-14 | Immunomedics, Inc. | Bifunctional linker |
US4669784A (en) | 1986-02-24 | 1987-06-02 | Palmer Grasse | Oscillated head and connecting element, with bearing support, for floor stripping machine |
US5088515A (en) | 1989-05-01 | 1992-02-18 | Kamen Dean L | Valve system with removable fluid interface |
US4948564A (en) * | 1986-10-28 | 1990-08-14 | Costar Corporation | Multi-well filter strip and composite assemblies |
EP0314469B1 (en) | 1987-10-27 | 1993-06-23 | Fujitsu Limited | Process and apparatus for preparation of single crystal of biopolymer |
US5032720A (en) | 1988-04-21 | 1991-07-16 | White John G | Confocal imaging system |
JP3169216B2 (en) | 1988-07-08 | 2001-05-21 | プロメガ・バイオサイエンシーズ・インコーポレイテッド | Production method and use of fluorescent benzothiazole derivative |
WO1990000754A1 (en) | 1988-07-13 | 1990-01-25 | Martin Russell Harris | Scanning confocal microscope |
US4898582A (en) | 1988-08-09 | 1990-02-06 | Pharmetrix Corporation | Portable infusion device assembly |
SE462408B (en) † | 1988-11-10 | 1990-06-18 | Pharmacia Ab | OPTICAL BIOSENSOR SYSTEM USING SURFACE MONITORING RESONSE FOR THE DETECTION OF A SPECIFIC BIOMOLIC CYCLE, TO CALIBRATE THE SENSOR DEVICE AND TO CORRECT FOUND BASELINE OPERATION IN THE SYSTEM |
US5004744A (en) * | 1988-12-13 | 1991-04-02 | Bayer Aktiengesellschaft | Pyridazinones as pesticides |
US5856092A (en) | 1989-02-13 | 1999-01-05 | Geneco Pty Ltd | Detection of a nucleic acid sequence or a change therein |
US5162946A (en) | 1989-03-07 | 1992-11-10 | Ricoh Company, Ltd. | Zoom viewfinder |
US4992312A (en) | 1989-03-13 | 1991-02-12 | Dow Corning Wright Corporation | Methods of forming permeation-resistant, silicone elastomer-containing composite laminates and devices produced thereby |
CH679555A5 (en) | 1989-04-11 | 1992-03-13 | Westonbridge Int Ltd | |
US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
US5007309A (en) * | 1989-06-08 | 1991-04-16 | Rockwell International Corporation | Automatic transmission control system and method of operation |
ES2061042T3 (en) | 1989-06-14 | 1994-12-01 | Westonbridge Int Ltd | PERFECTED MICROPUMP. |
US5171132A (en) | 1989-12-27 | 1992-12-15 | Seiko Epson Corporation | Two-valve thin plate micropump |
US5091652A (en) | 1990-01-12 | 1992-02-25 | The Regents Of The University Of California | Laser excited confocal microscope fluorescence scanner and method |
US6013431A (en) | 1990-02-16 | 2000-01-11 | Molecular Tool, Inc. | Method for determining specific nucleotide variations by primer extension in the presence of mixture of labeled nucleotides and terminators |
DE4006152A1 (en) | 1990-02-27 | 1991-08-29 | Fraunhofer Ges Forschung | MICROMINIATURIZED PUMP |
US5770029A (en) | 1996-07-30 | 1998-06-23 | Soane Biosciences | Integrated electrophoretic microdevices |
US5096388A (en) | 1990-03-22 | 1992-03-17 | The Charles Stark Draper Laboratory, Inc. | Microfabricated pump |
US5530100A (en) * | 1990-05-07 | 1996-06-25 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Methods for purification of recombinantly produced proteins |
SE470347B (en) | 1990-05-10 | 1994-01-31 | Pharmacia Lkb Biotech | Microstructure for fluid flow systems and process for manufacturing such a system |
DE69106240T2 (en) | 1990-07-02 | 1995-05-11 | Seiko Epson Corp | Micropump and method of making a micropump. |
GB2276169A (en) | 1990-07-05 | 1994-09-21 | Celltech Ltd | Antibodies specific for carcinoembryonic antigen |
GB9015793D0 (en) | 1990-07-18 | 1990-09-05 | Medical Res Council | Confocal scanning optical microscope |
US5401629A (en) | 1990-08-07 | 1995-03-28 | The Salk Institute Biotechnology/Industrial Associates, Inc. | Assay methods and compositions useful for measuring the transduction of an intracellular signal |
US5846710A (en) | 1990-11-02 | 1998-12-08 | St. Louis University | Method for the detection of genetic diseases and gene sequence variations by single nucleotide primer extension |
US5888819A (en) | 1991-03-05 | 1999-03-30 | Molecular Tool, Inc. | Method for determining nucleotide identity through primer extension |
US6004744A (en) | 1991-03-05 | 1999-12-21 | Molecular Tool, Inc. | Method for determining nucleotide identity through extension of immobilized primer |
WO1992016657A1 (en) | 1991-03-13 | 1992-10-01 | E.I. Du Pont De Nemours And Company | Method of identifying a nucleotide present at a defined position in a nucleic acid |
US5260578A (en) | 1991-04-10 | 1993-11-09 | Mayo Foundation For Medical Education And Research | Confocal imaging system for visible and ultraviolet light |
US5164558A (en) | 1991-07-05 | 1992-11-17 | Massachusetts Institute Of Technology | Micromachined threshold pressure switch and method of manufacture |
JP3328300B2 (en) | 1991-07-18 | 2002-09-24 | アイシン精機株式会社 | Fluid control device |
WO1993002216A1 (en) | 1991-07-19 | 1993-02-04 | Upstate Biotechnology, Inc. | Method for detection of mutations |
US5162941A (en) | 1991-07-23 | 1992-11-10 | The Board Of Governors Of Wayne State University | Confocal microscope |
US5168946A (en) | 1991-09-09 | 1992-12-08 | General Electric Company | Track-laying vehicle electric drive system |
DE4143343C2 (en) | 1991-09-11 | 1994-09-22 | Fraunhofer Ges Forschung | Microminiaturized, electrostatically operated micromembrane pump |
US5265327A (en) | 1991-09-13 | 1993-11-30 | Faris Sadeg M | Microchannel plate technology |
AU669489B2 (en) | 1991-09-18 | 1996-06-13 | Affymax Technologies N.V. | Method of synthesizing diverse collections of oligomers |
FR2684162B1 (en) † | 1991-11-27 | 1994-04-15 | Ysebaert | ELASTIC MEMBRANE VALVE. |
IT1255014B (en) † | 1992-03-27 | 1995-10-13 | Instrumentation Lab Spa | FLUIDS HANDLING AND INTERCEPTION DEVICES |
US5726026A (en) | 1992-05-01 | 1998-03-10 | Trustees Of The University Of Pennsylvania | Mesoscale sample preparation device and systems for determination and processing of analytes |
US5304487A (en) | 1992-05-01 | 1994-04-19 | Trustees Of The University Of Pennsylvania | Fluid handling in mesoscale analytical devices |
US5981176A (en) | 1992-06-17 | 1999-11-09 | City Of Hope | Method of detecting and discriminating between nucleic acid sequences |
DE4220077A1 (en) | 1992-06-19 | 1993-12-23 | Bosch Gmbh Robert | Micro-pump for delivery of gases - uses working chamber warmed by heating element and controlled by silicon wafer valves. |
US5710028A (en) | 1992-07-02 | 1998-01-20 | Eyal; Nurit | Method of quick screening and identification of specific DNA sequences by single nucleotide primer extension and kits therefor |
US5284568A (en) | 1992-07-17 | 1994-02-08 | E. I. Du Pont De Nemours And Company | Disposable cartridge for ion selective electrode sensors |
US5639423A (en) | 1992-08-31 | 1997-06-17 | The Regents Of The University Of Calfornia | Microfabricated reactor |
US5364742A (en) | 1992-09-21 | 1994-11-15 | International Business Machines Corporation | Micro-miniature structures and method of fabrication thereof |
DE69333087T2 (en) | 1992-10-01 | 2004-05-06 | The Trustees Of Columbia University In The City Of New York | COMPLEX COMBINATORY CHEMICAL BANKS WITH MARKINGS |
JP2812629B2 (en) | 1992-11-25 | 1998-10-22 | 宇宙開発事業団 | Crystal growth cell |
US5290240A (en) | 1993-02-03 | 1994-03-01 | Pharmetrix Corporation | Electrochemical controlled dispensing assembly and method for selective and controlled delivery of a dispensing fluid |
JP3152933B2 (en) * | 1993-05-17 | 2001-04-03 | アマーシャム・インターナショナル・ピーエルシー | Apparatus and method for measuring cell biochemical processes |
US5400741A (en) | 1993-05-21 | 1995-03-28 | Medical Foundation Of Buffalo, Inc. | Device for growing crystals |
EP0700485B1 (en) | 1993-05-27 | 1997-08-13 | Fraunhofer-Gesellschaft Zur Förderung Der Angewandten Forschung E.V. | Microvalve |
SE501713C2 (en) | 1993-09-06 | 1995-05-02 | Pharmacia Biosensor Ab | Diaphragm-type valve, especially for liquid handling blocks with micro-flow channels |
US5642015A (en) | 1993-07-14 | 1997-06-24 | The University Of British Columbia | Elastomeric micro electro mechanical systems |
US5543158A (en) | 1993-07-23 | 1996-08-06 | Massachusetts Institute Of Technology | Biodegradable injectable nanoparticles |
US5565215A (en) | 1993-07-23 | 1996-10-15 | Massachusettes Institute Of Technology | Biodegradable injectable particles for imaging |
US5659171A (en) | 1993-09-22 | 1997-08-19 | Northrop Grumman Corporation | Micro-miniature diaphragm pump for the low pressure pumping of gases |
CN1134156A (en) | 1993-11-02 | 1996-10-23 | 阿菲马克斯技术公司 | Synthesizing and screening molecular diversity |
CH689836A5 (en) | 1994-01-14 | 1999-12-15 | Westonbridge Int Ltd | Micropump. |
US5525490A (en) | 1994-03-29 | 1996-06-11 | Onyx Pharmaceuticals, Inc. | Reverse two-hybrid method |
US5547861A (en) | 1994-04-18 | 1996-08-20 | Becton, Dickinson And Company | Detection of nucleic acid amplification |
EP0758313A4 (en) | 1994-05-06 | 1999-09-15 | Pharmacopeia Inc | Combinatorial dihydrobenzopyran library |
US5663046A (en) | 1994-06-22 | 1997-09-02 | Pharmacopeia, Inc. | Synthesis of combinatorial libraries |
NZ291154A (en) | 1994-07-25 | 1997-11-24 | Boehringer Mannheim Gmbh | Di- or trivalent rare earth or transition metal complexes having three ligands, each of which has at least two nitrogen-containing heterocycles and complexed through nitrogen, and at least one reactive group bound to the ligard(s) |
US6001229A (en) | 1994-08-01 | 1999-12-14 | Lockheed Martin Energy Systems, Inc. | Apparatus and method for performing microfluidic manipulations for chemical analysis |
DE4433894A1 (en) | 1994-09-22 | 1996-03-28 | Fraunhofer Ges Forschung | Method and device for controlling a micropump |
EP0706004B1 (en) | 1994-10-07 | 2003-08-06 | Bayer Corporation | Relief valve |
US5695934A (en) | 1994-10-13 | 1997-12-09 | Lynx Therapeutics, Inc. | Massively parallel sequencing of sorted polynucleotides |
US5788468A (en) | 1994-11-03 | 1998-08-04 | Memstek Products, Llc | Microfabricated fluidic devices |
CA2204912C (en) | 1994-11-10 | 2005-01-04 | David Sarnoff Research Center, Inc. | Liquid distribution system |
US5593290A (en) † | 1994-12-22 | 1997-01-14 | Eastman Kodak Company | Micro dispensing positive displacement pump |
AU5171696A (en) | 1995-02-27 | 1996-09-18 | Ely Michael Rabani | Device, compounds, algorithms, and methods of molecular characterization and manipulation with molecular parallelism |
JP3094880B2 (en) | 1995-03-01 | 2000-10-03 | 住友金属工業株式会社 | Method for controlling crystallization of organic compound and solid state element for controlling crystallization used therein |
US5775371A (en) | 1995-03-08 | 1998-07-07 | Abbott Laboratories | Valve control |
US5876187A (en) | 1995-03-09 | 1999-03-02 | University Of Washington | Micropumps with fixed valves |
US6227809B1 (en) | 1995-03-09 | 2001-05-08 | University Of Washington | Method for making micropumps |
US5757482A (en) † | 1995-04-20 | 1998-05-26 | Perseptive Biosystems, Inc. | Module for optical detection in microscale fluidic analyses |
US5976822A (en) | 1995-05-18 | 1999-11-02 | Coulter International Corp. | Method and reagent for monitoring apoptosis and distinguishing apoptosis from necrosis |
CA2183478C (en) | 1995-08-17 | 2004-02-24 | Stephen A. Carter | Digital gas metering system using tri-stable and bi-stable solenoids |
US6130098A (en) | 1995-09-15 | 2000-10-10 | The Regents Of The University Of Michigan | Moving microdroplets |
US6132580A (en) | 1995-09-28 | 2000-10-17 | The Regents Of The University Of California | Miniature reaction chamber and devices incorporating same |
US5705018A (en) | 1995-12-13 | 1998-01-06 | Hartley; Frank T. | Micromachined peristaltic pump |
KR100207410B1 (en) | 1995-12-19 | 1999-07-15 | 전주범 | Fabrication method for lightpath modulation device |
US5863502A (en) * | 1996-01-24 | 1999-01-26 | Sarnoff Corporation | Parallel reaction cassette and associated devices |
US6803188B1 (en) | 1996-01-31 | 2004-10-12 | The Regents Of The University Of California | Tandem fluorescent protein constructs |
US5660370A (en) | 1996-03-07 | 1997-08-26 | Integrated Fludics, Inc. | Valve with flexible sheet member and two port non-flexing backer member |
US5942443A (en) | 1996-06-28 | 1999-08-24 | Caliper Technologies Corporation | High throughput screening assay systems in microscale fluidic devices |
US5867266A (en) | 1996-04-17 | 1999-02-02 | Cornell Research Foundation, Inc. | Multiple optical channels for chemical analysis |
US6177266B1 (en) | 1996-04-29 | 2001-01-23 | The United States Of America As Represented By The Secretary Of The Army | Rapid identification of bacteria by mass spectrometry |
FR2749663B1 (en) | 1996-06-07 | 1998-07-31 | Bio Merieux | SINGLE USE ANALYSIS CARD COMPRISING A LIQUID FLOW CONDUIT |
CA2259395C (en) | 1996-07-15 | 2002-03-05 | Sumitomo Metal Industries, Ltd. | Equipment for crystal growth and crystal-growing method using the same |
EP0956364A1 (en) | 1996-07-26 | 1999-11-17 | Genzyme Corporation | Whole cell assay |
WO1998005060A1 (en) | 1996-07-31 | 1998-02-05 | The Board Of Trustees Of The Leland Stanford Junior University | Multizone bake/chill thermal cycling module |
US6136212A (en) | 1996-08-12 | 2000-10-24 | The Regents Of The University Of Michigan | Polymer-based micromachining for microfluidic devices |
US6124128A (en) | 1996-08-16 | 2000-09-26 | The Regents Of The University Of California | Long wavelength engineered fluorescent proteins |
US5832165A (en) | 1996-08-28 | 1998-11-03 | University Of Utah Research Foundation | Composite waveguide for solid phase binding assays |
US5738799A (en) | 1996-09-12 | 1998-04-14 | Xerox Corporation | Method and materials for fabricating an ink-jet printhead |
US6221654B1 (en) | 1996-09-25 | 2001-04-24 | California Institute Of Technology | Method and apparatus for analysis and sorting of polynucleotides based on size |
US5971355A (en) | 1996-11-27 | 1999-10-26 | Xerox Corporation | Microdevice valve structures to fluid control |
DE69825601T2 (en) | 1997-02-12 | 2005-04-28 | Chan, Eugene Y, Brookline | METHOD FOR THE ANALYSIS OF POLYMERS |
JP2001521622A (en) | 1997-04-04 | 2001-11-06 | カリパー テクノロジーズ コーポレイション | Closed-loop biochemical analyzer |
US6229603B1 (en) * | 1997-06-02 | 2001-05-08 | Aurora Biosciences Corporation | Low background multi-well plates with greater than 864 wells for spectroscopic measurements |
US6171780B1 (en) * | 1997-06-02 | 2001-01-09 | Aurora Biosciences Corporation | Low fluorescence assay platforms and related methods for drug discovery |
US5910287A (en) * | 1997-06-03 | 1999-06-08 | Aurora Biosciences Corporation | Low background multi-well plates with greater than 864 wells for fluorescence measurements of biological and biochemical samples |
US5876946A (en) | 1997-06-03 | 1999-03-02 | Pharmacopeia, Inc. | High-throughput assay |
US5922604A (en) | 1997-06-05 | 1999-07-13 | Gene Tec Corporation | Thin reaction chambers for containing and handling liquid microvolumes |
US5869004A (en) | 1997-06-09 | 1999-02-09 | Caliper Technologies Corp. | Methods and apparatus for in situ concentration and/or dilution of materials in microfluidic systems |
US5888778A (en) | 1997-06-16 | 1999-03-30 | Exact Laboratories, Inc. | High-throughput screening method for identification of genetic mutations or disease-causing microorganisms using segmented primers |
AU8275998A (en) | 1997-06-27 | 1999-01-19 | Immunetics, Inc. | Rapid flow-through binding assay apparatus and method |
US6529612B1 (en) | 1997-07-16 | 2003-03-04 | Diversified Scientific, Inc. | Method for acquiring, storing and analyzing crystal images |
US6073482A (en) | 1997-07-21 | 2000-06-13 | Ysi Incorporated | Fluid flow module |
US5932799A (en) * | 1997-07-21 | 1999-08-03 | Ysi Incorporated | Microfluidic analyzer module |
US5972639A (en) | 1997-07-24 | 1999-10-26 | Irori | Fluorescence-based assays for measuring cell proliferation |
US5876675A (en) | 1997-08-05 | 1999-03-02 | Caliper Technologies Corp. | Microfluidic devices and systems |
JP2001516573A (en) | 1997-09-18 | 2001-10-02 | スミスクライン・ビーチャム・コーポレイション | Screening method for antimicrobial compounds |
TW352471B (en) | 1997-09-20 | 1999-02-11 | United Microelectronics Corp | Method for preventing B-P-Si glass from subsiding |
US7214298B2 (en) | 1997-09-23 | 2007-05-08 | California Institute Of Technology | Microfabricated cell sorter |
US6833242B2 (en) | 1997-09-23 | 2004-12-21 | California Institute Of Technology | Methods for detecting and sorting polynucleotides based on size |
US6540895B1 (en) * | 1997-09-23 | 2003-04-01 | California Institute Of Technology | Microfabricated cell sorter for chemical and biological materials |
WO1999018438A1 (en) | 1997-10-02 | 1999-04-15 | Aclara Biosciences, Inc. | Capillary assays involving separation of free and bound species |
US5836750A (en) | 1997-10-09 | 1998-11-17 | Honeywell Inc. | Electrostatically actuated mesopump having a plurality of elementary cells |
US5842787A (en) | 1997-10-09 | 1998-12-01 | Caliper Technologies Corporation | Microfluidic systems incorporating varied channel dimensions |
US5958694A (en) | 1997-10-16 | 1999-09-28 | Caliper Technologies Corp. | Apparatus and methods for sequencing nucleic acids in microfluidic systems |
US6345502B1 (en) | 1997-11-12 | 2002-02-12 | California Institute Of Technology | Micromachined parylene membrane valve and pump |
US6174675B1 (en) | 1997-11-25 | 2001-01-16 | Caliper Technologies Corp. | Electrical current for controlling fluid parameters in microchannels |
AU2459799A (en) | 1998-01-20 | 1999-08-02 | Triconex, Incorporated | Two out of three voting solenoid arrangement |
DE59905737D1 (en) | 1998-02-11 | 2003-07-03 | Inst Physikalische Hochtech Ev | MINIATURIZED TEMPERATURE ZONES RIVER REACTOR |
US6018616A (en) | 1998-02-23 | 2000-01-25 | Applied Materials, Inc. | Thermal cycling module and process using radiant heat |
US6388788B1 (en) * | 1998-03-16 | 2002-05-14 | Praelux, Inc. | Method and apparatus for screening chemical compounds |
WO1999052633A1 (en) | 1998-04-14 | 1999-10-21 | Ivd Systems | Test cartridge with a single inlet port |
ATE530891T1 (en) | 1998-05-22 | 2011-11-15 | California Inst Of Techn | MINIATURIZED CELL SORTER |
JPH11352409A (en) | 1998-06-05 | 1999-12-24 | Olympus Optical Co Ltd | Fluorescence detector |
CA2332919A1 (en) † | 1998-06-08 | 1999-12-16 | Caliper Technologies Corporation | Microfluidic devices, systems and methods for performing integrated reactions and separations |
WO2000000678A1 (en) | 1998-06-26 | 2000-01-06 | University Of Washington | Crystallization media |
US6132685A (en) | 1998-08-10 | 2000-10-17 | Caliper Technologies Corporation | High throughput microfluidic systems and methods |
US6146842A (en) | 1998-09-21 | 2000-11-14 | Mitotix, Inc. | High-throughput screening assays utilizing metal-chelate capture |
DE19843509A1 (en) | 1998-09-23 | 2000-06-21 | Fuhrmann Stephan | Setup for menu control |
US20030044776A1 (en) | 1998-09-25 | 2003-03-06 | James A. Dykens | Compositions and methods for identifying agents that alter mitochondrial permeability transition pores |
US6086740A (en) † | 1998-10-29 | 2000-07-11 | Caliper Technologies Corp. | Multiplexed microfluidic devices and systems |
RU2143343C1 (en) | 1998-11-03 | 1999-12-27 | Самсунг Электроникс Ко., Лтд. | Microinjector and microinjector manufacture method |
US6958865B1 (en) | 1998-11-12 | 2005-10-25 | California Institute Of Technology | Microlicensing particles and applications |
US6062261A (en) | 1998-12-16 | 2000-05-16 | Lockheed Martin Energy Research Corporation | MicrofluIdic circuit designs for performing electrokinetic manipulations that reduce the number of voltage sources and fluid reservoirs |
US6361671B1 (en) * | 1999-01-11 | 2002-03-26 | The Regents Of The University Of California | Microfabricated capillary electrophoresis chip and method for simultaneously detecting multiple redox labels |
US6150119A (en) | 1999-01-19 | 2000-11-21 | Caliper Technologies Corp. | Optimized high-throughput analytical system |
US6171850B1 (en) | 1999-03-08 | 2001-01-09 | Caliper Technologies Corp. | Integrated devices and systems for performing temperature controlled reactions and analyses |
WO2000053801A1 (en) | 1999-03-08 | 2000-09-14 | Merck Frosst Canada & Co. | Intact cell assay for protein tyrosine phosphatases |
WO2000056872A2 (en) * | 1999-03-22 | 2000-09-28 | Pangene Corporation | High-throughput gene cloning and phenotypic screening |
ATE357656T1 (en) | 1999-04-06 | 2007-04-15 | Univ Alabama Res Found | DEVICE FOR SCREENING CRYSTALIZATION CONDITIONS IN CRYSTAL GROWING SOLUTIONS |
US6346373B1 (en) | 1999-05-05 | 2002-02-12 | Merck Frosst Canada & Co., | Whole cell assay for cathepsin K activity |
GB9911095D0 (en) | 1999-05-13 | 1999-07-14 | Secr Defence | Microbiological test method and reagents |
US6225109B1 (en) | 1999-05-27 | 2001-05-01 | Orchid Biosciences, Inc. | Genetic analysis device |
US6296673B1 (en) | 1999-06-18 | 2001-10-02 | The Regents Of The University Of California | Methods and apparatus for performing array microcrystallizations |
US7306672B2 (en) | 2001-04-06 | 2007-12-11 | California Institute Of Technology | Microfluidic free interface diffusion techniques |
US7459022B2 (en) | 2001-04-06 | 2008-12-02 | California Institute Of Technology | Microfluidic protein crystallography |
US7601270B1 (en) * | 1999-06-28 | 2009-10-13 | California Institute Of Technology | Microfabricated elastomeric valve and pump systems |
US7144616B1 (en) | 1999-06-28 | 2006-12-05 | California Institute Of Technology | Microfabricated elastomeric valve and pump systems |
US6899137B2 (en) | 1999-06-28 | 2005-05-31 | California Institute Of Technology | Microfabricated elastomeric valve and pump systems |
WO2001007061A1 (en) | 1999-07-27 | 2001-02-01 | Smithkline Beecham Corporation | Whole cell assay |
US6977145B2 (en) * | 1999-07-28 | 2005-12-20 | Serono Genetics Institute S.A. | Method for carrying out a biochemical protocol in continuous flow in a microreactor |
AU6396500A (en) | 1999-08-02 | 2001-02-19 | Emerald Biostructures, Inc. | Method and system for creating a crystallization results database |
GB9923324D0 (en) | 1999-10-01 | 1999-12-08 | Pyrosequencing Ab | Separation apparatus and method |
DE29917313U1 (en) | 1999-10-01 | 2001-02-15 | Mwg Biotech Ag | Device for carrying out chemical or biological reactions |
US6531318B1 (en) | 1999-10-08 | 2003-03-11 | The General Hospital Corporation | Methods and apparatus for cell analysis |
WO2001032930A1 (en) | 1999-11-04 | 2001-05-10 | California Institute Of Technology | Methods and apparatuses for analyzing polynucleotide sequences |
WO2001067369A2 (en) | 2000-03-03 | 2001-09-13 | California Institute Of Technology | Combinatorial array for nucleic acid analysis |
AU2001251218B2 (en) * | 2000-03-31 | 2006-06-29 | Perkinelmer Health Sciences, Inc. | Protein crystallization in microfluidic structures |
US7867763B2 (en) | 2004-01-25 | 2011-01-11 | Fluidigm Corporation | Integrated chip carriers with thermocycler interfaces and methods of using the same |
US20050118073A1 (en) | 2003-11-26 | 2005-06-02 | Fluidigm Corporation | Devices and methods for holding microfluidic devices |
EP1284818B1 (en) * | 2000-05-15 | 2006-11-22 | Tecan Trading AG | Bidirectional flow centrifugal microfluidic devices |
US7351376B1 (en) * | 2000-06-05 | 2008-04-01 | California Institute Of Technology | Integrated active flux microfluidic devices and methods |
AU2001273057A1 (en) * | 2000-06-27 | 2002-01-08 | Fluidigm Corporation | A microfluidic design automation method and system |
US6885982B2 (en) * | 2000-06-27 | 2005-04-26 | Fluidigm Corporation | Object oriented microfluidic design method and system |
US6301055B1 (en) * | 2000-08-16 | 2001-10-09 | California Institute Of Technology | Solid immersion lens structures and methods for producing solid immersion lens structures |
US6902702B1 (en) * | 2000-08-16 | 2005-06-07 | University Health Network | Devices and methods for producing microarrays of biological samples |
AU2001290879A1 (en) | 2000-09-15 | 2002-03-26 | California Institute Of Technology | Microfabricated crossflow devices and methods |
WO2002022787A2 (en) * | 2000-09-18 | 2002-03-21 | President And Fellows Of Harvard College | Differential treatment of selected parts of a single cell with different fluid components |
US7097809B2 (en) | 2000-10-03 | 2006-08-29 | California Institute Of Technology | Combinatorial synthesis system |
EP1322936A2 (en) | 2000-10-03 | 2003-07-02 | California Institute Of Technology | Microfluidic devices and methods of use |
US7678547B2 (en) * | 2000-10-03 | 2010-03-16 | California Institute Of Technology | Velocity independent analyte characterization |
US6827095B2 (en) * | 2000-10-12 | 2004-12-07 | Nanostream, Inc. | Modular microfluidic systems |
EP1336097A4 (en) | 2000-10-13 | 2006-02-01 | Fluidigm Corp | Microfluidic device based sample injection system for analytical devices |
DE60103924T2 (en) * | 2000-11-06 | 2005-07-14 | Nanostream, Inc., Pasadena | MICROFLUID FLOW RATE DEVICE |
US7232109B2 (en) * | 2000-11-06 | 2007-06-19 | California Institute Of Technology | Electrostatic valves for microfluidic devices |
EP1343973B2 (en) | 2000-11-16 | 2020-09-16 | California Institute Of Technology | Apparatus and methods for conducting assays and high throughput screening |
US6951632B2 (en) | 2000-11-16 | 2005-10-04 | Fluidigm Corporation | Microfluidic devices for introducing and dispensing fluids from microfluidic systems |
US7135296B2 (en) | 2000-12-28 | 2006-11-14 | Mds Inc. | Elemental analysis of tagged biologically active materials |
CA2440754A1 (en) | 2001-03-12 | 2002-09-19 | Stephen Quake | Methods and apparatus for analyzing polynucleotide sequences by asynchronous base extension |
US6960437B2 (en) | 2001-04-06 | 2005-11-01 | California Institute Of Technology | Nucleic acid amplification utilizing microfluidic devices |
US6802342B2 (en) | 2001-04-06 | 2004-10-12 | Fluidigm Corporation | Microfabricated fluidic circuit elements and applications |
ATE500051T1 (en) * | 2001-04-06 | 2011-03-15 | Fluidigm Corp | POLYMER SURFACE MODIFICATION |
US6752922B2 (en) * | 2001-04-06 | 2004-06-22 | Fluidigm Corporation | Microfluidic chromatography |
US7075162B2 (en) | 2001-08-30 | 2006-07-11 | Fluidigm Corporation | Electrostatic/electrostrictive actuation of elastomer structures using compliant electrodes |
WO2003031163A2 (en) | 2001-10-08 | 2003-04-17 | California Institute Of Technology | Microfabricated lenses, methods of manufacture thereof, and applications therefor |
WO2003031066A1 (en) * | 2001-10-11 | 2003-04-17 | California Institute Of Technology | Devices utilizing self-assembled gel and method of manufacture |
EP1463796B1 (en) | 2001-11-30 | 2013-01-09 | Fluidigm Corporation | Microfluidic device and methods of using same |
US7691333B2 (en) * | 2001-11-30 | 2010-04-06 | Fluidigm Corporation | Microfluidic device and methods of using same |
WO2003085379A2 (en) * | 2002-04-01 | 2003-10-16 | Fluidigm Corporation | Microfluidic particle-analysis systems |
US7059348B2 (en) * | 2002-05-13 | 2006-06-13 | Fluidigm Corporation | Drug delivery system |
US8168139B2 (en) | 2002-06-24 | 2012-05-01 | Fluidigm Corporation | Recirculating fluidic network and methods for using the same |
US7143785B2 (en) * | 2002-09-25 | 2006-12-05 | California Institute Of Technology | Microfluidic large scale integration |
JP5695287B2 (en) * | 2002-10-02 | 2015-04-01 | カリフォルニア インスティテュート オブ テクノロジー | Nucleic acid analysis of microfluids |
GB0302302D0 (en) | 2003-01-31 | 2003-03-05 | Glaxo Group Ltd | Microfluidic apparatus and method |
US7476363B2 (en) * | 2003-04-03 | 2009-01-13 | Fluidigm Corporation | Microfluidic devices and methods of using same |
AU2004228678A1 (en) | 2003-04-03 | 2004-10-21 | Fluidigm Corp. | Microfluidic devices and methods of using same |
US7604965B2 (en) | 2003-04-03 | 2009-10-20 | Fluidigm Corporation | Thermal reaction device and method for using the same |
US8828663B2 (en) | 2005-03-18 | 2014-09-09 | Fluidigm Corporation | Thermal reaction device and method for using the same |
US20050145496A1 (en) | 2003-04-03 | 2005-07-07 | Federico Goodsaid | Thermal reaction device and method for using the same |
WO2004094020A2 (en) | 2003-04-17 | 2004-11-04 | Fluidigm Corporation | Crystal growth devices and systems, and methods for using same |
WO2004103563A2 (en) | 2003-05-20 | 2004-12-02 | Fluidigm Corporation | Method and system for microfluidic device and imaging thereof |
WO2005011947A2 (en) | 2003-07-28 | 2005-02-10 | Fluidigm Corporation | Image processing method and system for microfluidic devices |
US7413712B2 (en) * | 2003-08-11 | 2008-08-19 | California Institute Of Technology | Microfluidic rotary flow reactor matrix |
US7042649B2 (en) * | 2003-08-11 | 2006-05-09 | California Institute Of Technology | Microfabricated rubber microscope using soft solid immersion lenses |
WO2005054441A2 (en) | 2003-12-01 | 2005-06-16 | California Institute Of Technology | Device for immobilizing chemical and biomedical species and methods of using same |
US7407799B2 (en) * | 2004-01-16 | 2008-08-05 | California Institute Of Technology | Microfluidic chemostat |
CN102680440A (en) | 2004-06-07 | 2012-09-19 | 先锋生物科技股份有限公司 | Optical lens system and method for microfluidic devices |
JP2008522795A (en) | 2004-12-03 | 2008-07-03 | カリフォルニア インスティチュート オブ テクノロジー | Microfluidic device with chemical reaction circuit |
US20080264863A1 (en) | 2004-12-03 | 2008-10-30 | California Institute Of Technology | Microfluidic Sieve Valves |
WO2006127191A2 (en) | 2005-04-20 | 2006-11-30 | Fluidigm Corporation | Analysis engine and database for manipulating parameters for fluidic systems on a chip |
WO2007044091A2 (en) | 2005-06-02 | 2007-04-19 | Fluidigm Corporation | Analysis using microfluidic partitioning devices |
US20070054293A1 (en) | 2005-08-30 | 2007-03-08 | California Institute Of Technology | Microfluidic chaotic mixing systems and methods |
EP1938101A2 (en) | 2005-09-13 | 2008-07-02 | Fluidigm Corporation | Microfluidic assay devices and methods |
US8206975B2 (en) * | 2005-10-28 | 2012-06-26 | California Institute Of Technology | Method and device for regulating fluid flow in microfluidic devices |
US20070248971A1 (en) | 2006-01-26 | 2007-10-25 | California Institute Of Technology | Programming microfluidic devices with molecular information |
EP1987358A4 (en) | 2006-01-26 | 2013-12-04 | California Inst Of Techn | Mechanically induced trapping of molecular interactions |
US7815868B1 (en) | 2006-02-28 | 2010-10-19 | Fluidigm Corporation | Microfluidic reaction apparatus for high throughput screening |
US8828661B2 (en) * | 2006-04-24 | 2014-09-09 | Fluidigm Corporation | Methods for detection and quantification of nucleic acid or protein targets in a sample |
JP2009543467A (en) | 2006-07-05 | 2009-12-03 | アギア システムズ インコーポレーテッド | System and method for implementing a hands-free operating environment |
US8055034B2 (en) * | 2006-09-13 | 2011-11-08 | Fluidigm Corporation | Methods and systems for image processing of microfluidic devices |
WO2008043046A2 (en) | 2006-10-04 | 2008-04-10 | Fluidigm Corporation | Microfluidic check valves |
WO2008067552A2 (en) * | 2006-11-30 | 2008-06-05 | Fluidigm Corporation | Method and apparatus for biological sample analysis |
WO2008089493A2 (en) | 2007-01-19 | 2008-07-24 | Fluidigm Corporation | High precision microfluidic devices and methods |
WO2008141183A2 (en) * | 2007-05-09 | 2008-11-20 | Fluidigm Corporation | Method and system for crystallization and x-ray diffraction screening |
WO2009033178A1 (en) * | 2007-09-07 | 2009-03-12 | Fluidigm Corporation | Copy number variation determination, methods and systems |
US7700925B2 (en) | 2007-12-28 | 2010-04-20 | Varian Semiconductor Equipment Associates, Inc. | Techniques for providing a multimode ion source |
US9157116B2 (en) | 2008-02-08 | 2015-10-13 | Fluidigm Corporation | Combinatorial amplification and detection of nucleic acids |
US9487822B2 (en) | 2008-03-19 | 2016-11-08 | Fluidigm Corporation | Method and apparatus for determining copy number variation using digital PCR |
CN104043490A (en) | 2008-07-25 | 2014-09-17 | 弗卢丁公司 | Method and system for manufacturing integrated fluidic chips |
WO2010017210A1 (en) | 2008-08-07 | 2010-02-11 | Fluidigm Corporation | Microfluidic mixing and reaction systems for high efficiency screening |
CN104741159B (en) | 2008-12-08 | 2017-01-18 | 富鲁达公司 | Programmable microfluidic digital array |
US8058630B2 (en) | 2009-01-16 | 2011-11-15 | Fluidigm Corporation | Microfluidic devices and methods |
WO2011053790A2 (en) | 2009-10-30 | 2011-05-05 | Fluidigm Corporation | Assay of closely linked targets in fetal diagnosis and coincidence detection assay for genetic analysis |
-
2001
- 2001-11-16 EP EP01990762.5A patent/EP1343973B2/en not_active Expired - Lifetime
- 2001-11-16 AU AU2002230524A patent/AU2002230524A1/en not_active Abandoned
- 2001-11-16 WO PCT/US2001/044869 patent/WO2002040874A1/en active Search and Examination
- 2001-11-16 US US10/416,418 patent/US7378280B2/en not_active Expired - Fee Related
- 2001-11-16 EP EP11161890A patent/EP2381116A1/en not_active Withdrawn
-
2008
- 2008-05-27 US US12/127,720 patent/US7887753B2/en not_active Expired - Fee Related
-
2011
- 2011-02-14 US US13/026,587 patent/US8273574B2/en not_active Expired - Lifetime
- 2011-02-15 US US13/027,768 patent/US8455258B2/en not_active Expired - Lifetime
-
2012
- 2012-09-04 US US13/603,263 patent/US8673645B2/en not_active Expired - Lifetime
-
2014
- 2014-03-17 US US14/216,740 patent/US9176137B2/en not_active Expired - Fee Related
-
2015
- 2015-10-30 US US14/928,631 patent/US10509018B2/en not_active Expired - Fee Related
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5922591A (en) * | 1995-06-29 | 1999-07-13 | Affymetrix, Inc. | Integrated nucleic acid diagnostic device |
US6197595B1 (en) * | 1995-06-29 | 2001-03-06 | Affymetrix, Inc. | Integrated nucleic acid diagnostic device |
US5958344A (en) | 1995-11-09 | 1999-09-28 | Sarnoff Corporation | System for liquid distribution |
US6306659B1 (en) * | 1996-06-28 | 2001-10-23 | Caliper Technologies Corp. | High throughput screening assay systems in microscale fluidic devices |
US6235471B1 (en) * | 1997-04-04 | 2001-05-22 | Caliper Technologies Corp. | Closed-loop biochemical analyzers |
US6167910B1 (en) * | 1998-01-20 | 2001-01-02 | Caliper Technologies Corp. | Multi-layer microfluidic devices |
US6321791B1 (en) * | 1998-01-20 | 2001-11-27 | Caliper Technologies Corp. | Multi-layer microfluidic devices |
Cited By (132)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9926521B2 (en) | 2000-06-27 | 2018-03-27 | Fluidigm Corporation | Microfluidic particle-analysis systems |
US7887753B2 (en) | 2000-11-16 | 2011-02-15 | California Institute Of Technology | Apparatus and methods for conducting assays and high throughput screening |
US8673645B2 (en) | 2000-11-16 | 2014-03-18 | California Institute Of Technology | Apparatus and methods for conducting assays and high throughput screening |
US10509018B2 (en) | 2000-11-16 | 2019-12-17 | California Institute Of Technology | Apparatus and methods for conducting assays and high throughput screening |
US8455258B2 (en) | 2000-11-16 | 2013-06-04 | California Insitute Of Technology | Apparatus and methods for conducting assays and high throughput screening |
US9176137B2 (en) | 2000-11-16 | 2015-11-03 | California Institute Of Technology | Apparatus and methods for conducting assays and high throughput screening |
US8273574B2 (en) | 2000-11-16 | 2012-09-25 | California Institute Of Technology | Apparatus and methods for conducting assays and high throughput screening |
US8486636B2 (en) | 2001-04-06 | 2013-07-16 | California Institute Of Technology | Nucleic acid amplification using microfluidic devices |
US7833708B2 (en) | 2001-04-06 | 2010-11-16 | California Institute Of Technology | Nucleic acid amplification using microfluidic devices |
US8936764B2 (en) | 2001-04-06 | 2015-01-20 | California Institute Of Technology | Nucleic acid amplification using microfluidic devices |
US9643178B2 (en) | 2001-11-30 | 2017-05-09 | Fluidigm Corporation | Microfluidic device with reaction sites configured for blind filling |
EP2360234A1 (en) * | 2001-11-30 | 2011-08-24 | Fluidigm Corporation | Microfluidic device and methods of using same |
US8163492B2 (en) | 2001-11-30 | 2012-04-24 | Fluidign Corporation | Microfluidic device and methods of using same |
US7820427B2 (en) | 2001-11-30 | 2010-10-26 | Fluidigm Corporation | Microfluidic device and methods of using same |
WO2004025128A1 (en) * | 2002-09-10 | 2004-03-25 | Canon Kabushiki Kaisha | Liquid delivery device |
US7302970B2 (en) | 2002-09-10 | 2007-12-04 | Canon Kabushiki Kaisha | Liquid delivery device |
US9714443B2 (en) | 2002-09-25 | 2017-07-25 | California Institute Of Technology | Microfabricated structure having parallel and orthogonal flow channels controlled by row and column multiplexors |
US8220494B2 (en) | 2002-09-25 | 2012-07-17 | California Institute Of Technology | Microfluidic large scale integration |
EP2298448A2 (en) * | 2002-09-25 | 2011-03-23 | California Institute of Technology | Microfluidic large scale integration |
US10328428B2 (en) | 2002-10-02 | 2019-06-25 | California Institute Of Technology | Apparatus for preparing cDNA libraries from single cells |
US9579650B2 (en) | 2002-10-02 | 2017-02-28 | California Institute Of Technology | Microfluidic nucleic acid analysis |
US8871446B2 (en) | 2002-10-02 | 2014-10-28 | California Institute Of Technology | Microfluidic nucleic acid analysis |
US10940473B2 (en) | 2002-10-02 | 2021-03-09 | California Institute Of Technology | Microfluidic nucleic acid analysis |
EP1549768A4 (en) * | 2002-10-04 | 2011-05-04 | California Inst Of Techn | Microfluidic protein crystallography |
US8012680B2 (en) * | 2003-03-24 | 2011-09-06 | Sony Corporation | Microchip, nucleic acid extracting kit, and nucleic acid extracting method |
US10131934B2 (en) | 2003-04-03 | 2018-11-20 | Fluidigm Corporation | Thermal reaction device and method for using the same |
US7964139B2 (en) | 2003-08-11 | 2011-06-21 | California Institute Of Technology | Microfluidic rotary flow reactor matrix |
EP1664601A4 (en) * | 2003-08-11 | 2006-11-02 | California Inst Of Techn | Microfluidic large scale integration |
EP1664601A2 (en) * | 2003-08-11 | 2006-06-07 | California Institute Of Technology | Microfluidic large scale integration |
EP1670898A2 (en) * | 2003-08-11 | 2006-06-21 | California Institute of Technology | Microfluidic rotary flow reactor matrix |
EP1670898A4 (en) * | 2003-08-11 | 2007-03-21 | California Inst Of Techn | Microfluidic rotary flow reactor matrix |
US7413712B2 (en) * | 2003-08-11 | 2008-08-19 | California Institute Of Technology | Microfluidic rotary flow reactor matrix |
US10967338B2 (en) | 2003-09-05 | 2021-04-06 | Stokes Bio Ltd. | Methods of releasing and analyzing cellular components |
US11807902B2 (en) | 2003-09-05 | 2023-11-07 | Stokes Bio Ltd. | Microfluidic analysis system |
US10676786B2 (en) | 2003-09-05 | 2020-06-09 | Stokes Bio Ltd. | Microfluidic analysis system |
WO2005056813A2 (en) | 2003-12-05 | 2005-06-23 | California Institute Of Technology | Microfluidic protein crystallography techniques |
US7799277B2 (en) * | 2003-12-08 | 2010-09-21 | Canon Kabushiki Kaisha | Detection device and detection method |
JPWO2005121308A1 (en) * | 2004-06-08 | 2008-04-10 | コニカミノルタエムジー株式会社 | Microreactor with efficient liquid mixing and reaction |
WO2005121308A1 (en) * | 2004-06-08 | 2005-12-22 | Konica Minolta Medical & Graphic, Inc. | Microreactor enhancing efficiency of liquid mixing and reaction |
US7955504B1 (en) * | 2004-10-06 | 2011-06-07 | State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University | Microfluidic devices, particularly filtration devices comprising polymeric membranes, and method for their manufacture and use |
EP1806393A4 (en) * | 2004-10-27 | 2011-01-26 | Konica Minolta Med & Graphic | Microreactor for genetic test |
EP1806393A1 (en) * | 2004-10-27 | 2007-07-11 | Konica Minolta Medical & Graphic, Inc. | Microreactor for genetic test |
US9364829B2 (en) * | 2005-06-02 | 2016-06-14 | Fluidigm Corporation | Analysis using microfluidic partitioning devices |
US20110129841A1 (en) * | 2005-06-02 | 2011-06-02 | Fluidigm Corporation | Analysis using microfluidic partitioning devices |
US8075851B2 (en) | 2005-09-29 | 2011-12-13 | Siemens Medical Solutions Usa, Inc. | Microfluidic chip capable of synthesizing radioactively labeled molecules on a scale suitable for human imaging with positron emission tomography |
WO2007041486A2 (en) | 2005-09-29 | 2007-04-12 | Siemens Medical Solutions Usa, Inc. | Microfluidic chip for synthesizing radioactively labeled molecules suitable for human imaging with positron emission tomography |
JP2009510454A (en) * | 2005-09-29 | 2009-03-12 | シーメンス メディカル ソリューションズ ユーエスエー インコーポレイテッド | A microfluidic chip that can synthesize molecules labeled with radioactive substances on a scale suitable for human body imaging by positron emission tomography |
US8658112B2 (en) | 2005-09-29 | 2014-02-25 | Siemens Medical Solutions Usa, Inc. | Microfluidic chip capable of synthesizing radioactively labeled molecules on a scale suitable for human imaging with positron emission tomography |
WO2007041486A3 (en) * | 2005-09-29 | 2007-06-07 | Siemens Medical Solutions | Microfluidic chip for synthesizing radioactively labeled molecules suitable for human imaging with positron emission tomography |
WO2007064635A1 (en) * | 2005-11-30 | 2007-06-07 | Micronics, Inc. | Microfluidic mixing and analytical apparatus and method for affinity capture of a ligand |
US9056291B2 (en) | 2005-11-30 | 2015-06-16 | Micronics, Inc. | Microfluidic reactor system |
US7763453B2 (en) | 2005-11-30 | 2010-07-27 | Micronics, Inc. | Microfluidic mixing and analytic apparatus |
US7955836B2 (en) | 2005-11-30 | 2011-06-07 | Micronics, Inc. | Microfluidic mixing and analytical apparatus |
US9468894B2 (en) | 2005-11-30 | 2016-10-18 | Micronics, Inc. | Microfluidic mixing and analytical apparatus |
US11772096B2 (en) | 2006-02-07 | 2023-10-03 | Stokes Bio Ltd. | System for processing biological sample |
US10730051B2 (en) | 2006-02-07 | 2020-08-04 | Stokes Bio Ltd. | Liquid bridge and system |
US8420017B2 (en) | 2006-02-28 | 2013-04-16 | Fluidigm Corporation | Microfluidic reaction apparatus for high throughput screening |
US7815868B1 (en) | 2006-02-28 | 2010-10-19 | Fluidigm Corporation | Microfluidic reaction apparatus for high throughput screening |
US7829032B2 (en) | 2007-01-23 | 2010-11-09 | Siemens Medical Solutions Usa, Inc. | Fully-automated microfluidic system for the synthesis of radiolabeled biomarkers for positron emission tomography |
US8173073B2 (en) | 2007-04-12 | 2012-05-08 | Siemens Medical Solutions Usa, Inc. | Portable microfluidic radiosynthesis system for positron emission tomography biomarkers and program code |
US8071035B2 (en) | 2007-04-12 | 2011-12-06 | Siemens Medical Solutions Usa, Inc. | Microfluidic radiosynthesis system for positron emission tomography biomarkers |
EP2119503A2 (en) | 2008-05-13 | 2009-11-18 | Commissariat a L'Energie Atomique | Microfluid system and method for sorting clusters of cells and continuously encapsulating them once they are sorted |
US11964244B2 (en) | 2009-11-12 | 2024-04-23 | Stokes Bio Limited | Methods of releasing and analyzing cellular components |
US9545469B2 (en) | 2009-12-05 | 2017-01-17 | Outset Medical, Inc. | Dialysis system with ultrafiltration control |
US11761030B2 (en) | 2010-04-05 | 2023-09-19 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
US11634756B2 (en) | 2010-04-05 | 2023-04-25 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
US11479810B1 (en) | 2010-04-05 | 2022-10-25 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
US11866770B2 (en) | 2010-04-05 | 2024-01-09 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
US11542543B2 (en) | 2010-04-05 | 2023-01-03 | Prognosys Biosciences, Inc. | System for analyzing targets of a tissue section |
US11549138B2 (en) | 2010-04-05 | 2023-01-10 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
US11767550B2 (en) | 2010-04-05 | 2023-09-26 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
US11519022B2 (en) | 2010-04-05 | 2022-12-06 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
US11733238B2 (en) | 2010-04-05 | 2023-08-22 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
US11732292B2 (en) | 2010-04-05 | 2023-08-22 | Prognosys Biosciences, Inc. | Spatially encoded biological assays correlating target nucleic acid to tissue section location |
US11560587B2 (en) | 2010-04-05 | 2023-01-24 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
US10668201B2 (en) | 2010-06-07 | 2020-06-02 | Oregon State University | Dialysis system |
US11724013B2 (en) | 2010-06-07 | 2023-08-15 | Outset Medical, Inc. | Fluid purification system |
US9895480B2 (en) | 2010-06-07 | 2018-02-20 | Oregon State University | Dialysis system |
US10105476B2 (en) | 2010-06-07 | 2018-10-23 | Oregon State University | Fluid purification system |
US9138687B2 (en) | 2010-06-07 | 2015-09-22 | Oregon State University | Fluid purification system |
US11795498B2 (en) | 2011-04-13 | 2023-10-24 | 10X Genomics Sweden Ab | Methods of detecting analytes |
US11788122B2 (en) | 2011-04-13 | 2023-10-17 | 10X Genomics Sweden Ab | Methods of detecting analytes |
US11479809B2 (en) | 2011-04-13 | 2022-10-25 | Spatial Transcriptomics Ab | Methods of detecting analytes |
US9328969B2 (en) | 2011-10-07 | 2016-05-03 | Outset Medical, Inc. | Heat exchange fluid purification for dialysis system |
GB2495536A (en) * | 2011-10-14 | 2013-04-17 | J R Biomedical Ltd | Bioanalytical device with mixing device |
US10549281B2 (en) | 2012-04-03 | 2020-02-04 | Illumina, Inc. | Integrated optoelectronic read head and fluidic cartridge useful for nucleic acid sequencing |
AU2016222420B2 (en) * | 2012-04-03 | 2019-01-03 | Illumina, Inc. | Integrated Optoelectronic Read Head and Fluidic Cartridge Useful for Nucleic Acid Sequencing |
US9840732B2 (en) | 2012-05-21 | 2017-12-12 | Fluidigm Corporation | Single-particle analysis of particle populations |
CN105188932A (en) * | 2013-04-30 | 2015-12-23 | 皇家飞利浦有限公司 | Fluidic system for processing a sample fluid |
US10493445B2 (en) | 2013-04-30 | 2019-12-03 | Koninklijke Philips N.V. | Fluidic system for processing a sample fluid |
CN105188932B (en) * | 2013-04-30 | 2018-05-08 | 皇家飞利浦有限公司 | For handling the fluid system of sample fluid |
US11618918B2 (en) * | 2013-06-25 | 2023-04-04 | Prognosys Biosciences, Inc. | Methods and systems for determining spatial patterns of biological targets in a sample |
US11821024B2 (en) | 2013-06-25 | 2023-11-21 | Prognosys Biosciences, Inc. | Methods and systems for determining spatial patterns of biological targets in a sample |
US11753674B2 (en) | 2013-06-25 | 2023-09-12 | Prognosys Biosciences, Inc. | Methods and systems for determining spatial patterns of biological targets in a sample |
US9402945B2 (en) | 2014-04-29 | 2016-08-02 | Outset Medical, Inc. | Dialysis system and methods |
US9504777B2 (en) | 2014-04-29 | 2016-11-29 | Outset Medical, Inc. | Dialysis system and methods |
US11305040B2 (en) | 2014-04-29 | 2022-04-19 | Outset Medical, Inc. | Dialysis system and methods |
US9579440B2 (en) | 2014-04-29 | 2017-02-28 | Outset Medical, Inc. | Dialysis system and methods |
US11739372B2 (en) | 2015-04-10 | 2023-08-29 | Spatial Transcriptomics Ab | Spatially distinguished, multiplex nucleic acid analysis of biological specimens |
US11613773B2 (en) | 2015-04-10 | 2023-03-28 | Spatial Transcriptomics Ab | Spatially distinguished, multiplex nucleic acid analysis of biological specimens |
US11951241B2 (en) | 2016-08-19 | 2024-04-09 | Outset Medical, Inc. | Peritoneal dialysis system and methods |
US11534537B2 (en) | 2016-08-19 | 2022-12-27 | Outset Medical, Inc. | Peritoneal dialysis system and methods |
US11933957B1 (en) | 2018-12-10 | 2024-03-19 | 10X Genomics, Inc. | Imaging system hardware |
US11649485B2 (en) | 2019-01-06 | 2023-05-16 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
US11926867B2 (en) | 2019-01-06 | 2024-03-12 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
US11753675B2 (en) | 2019-01-06 | 2023-09-12 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
CN113711052A (en) * | 2019-05-17 | 2021-11-26 | 株式会社日立高新技术 | Automatic analyzer |
US11965213B2 (en) | 2019-05-30 | 2024-04-23 | 10X Genomics, Inc. | Methods of detecting spatial heterogeneity of a biological sample |
US11702698B2 (en) | 2019-11-08 | 2023-07-18 | 10X Genomics, Inc. | Enhancing specificity of analyte binding |
US11795507B2 (en) | 2019-12-23 | 2023-10-24 | 10X Genomics, Inc. | Methods for spatial analysis using RNA-templated ligation |
US11560593B2 (en) | 2019-12-23 | 2023-01-24 | 10X Genomics, Inc. | Methods for spatial analysis using RNA-templated ligation |
US11702693B2 (en) | 2020-01-21 | 2023-07-18 | 10X Genomics, Inc. | Methods for printing cells and generating arrays of barcoded cells |
US11732299B2 (en) | 2020-01-21 | 2023-08-22 | 10X Genomics, Inc. | Spatial assays with perturbed cells |
US11898205B2 (en) | 2020-02-03 | 2024-02-13 | 10X Genomics, Inc. | Increasing capture efficiency of spatial assays |
US11732300B2 (en) | 2020-02-05 | 2023-08-22 | 10X Genomics, Inc. | Increasing efficiency of spatial analysis in a biological sample |
US11773433B2 (en) | 2020-04-22 | 2023-10-03 | 10X Genomics, Inc. | Methods for spatial analysis using targeted RNA depletion |
US11959130B2 (en) | 2020-05-22 | 2024-04-16 | 10X Genomics, Inc. | Spatial analysis to detect sequence variants |
US11866767B2 (en) | 2020-05-22 | 2024-01-09 | 10X Genomics, Inc. | Simultaneous spatio-temporal measurement of gene expression and cellular activity |
US11624086B2 (en) | 2020-05-22 | 2023-04-11 | 10X Genomics, Inc. | Simultaneous spatio-temporal measurement of gene expression and cellular activity |
US11624063B2 (en) | 2020-06-08 | 2023-04-11 | 10X Genomics, Inc. | Methods of determining a surgical margin and methods of use thereof |
US11781130B2 (en) | 2020-06-08 | 2023-10-10 | 10X Genomics, Inc. | Methods of determining a surgical margin and methods of use thereof |
US11661626B2 (en) | 2020-06-25 | 2023-05-30 | 10X Genomics, Inc. | Spatial analysis of DNA methylation |
US11761038B1 (en) | 2020-07-06 | 2023-09-19 | 10X Genomics, Inc. | Methods for identifying a location of an RNA in a biological sample |
US11952627B2 (en) | 2020-07-06 | 2024-04-09 | 10X Genomics, Inc. | Methods for identifying a location of an RNA in a biological sample |
US11926822B1 (en) | 2020-09-23 | 2024-03-12 | 10X Genomics, Inc. | Three-dimensional spatial analysis |
US11827935B1 (en) | 2020-11-19 | 2023-11-28 | 10X Genomics, Inc. | Methods for spatial analysis using rolling circle amplification and detection probes |
US11873482B2 (en) | 2020-12-21 | 2024-01-16 | 10X Genomics, Inc. | Methods, compositions, and systems for spatial analysis of analytes in a biological sample |
US11959076B2 (en) | 2020-12-21 | 2024-04-16 | 10X Genomics, Inc. | Methods, compositions, and systems for capturing probes and/or barcodes |
US11680260B2 (en) | 2020-12-21 | 2023-06-20 | 10X Genomics, Inc. | Methods, compositions, and systems for spatial analysis of analytes in a biological sample |
US11618897B2 (en) | 2020-12-21 | 2023-04-04 | 10X Genomics, Inc. | Methods, compositions, and systems for capturing probes and/or barcodes |
US11840724B2 (en) | 2021-09-01 | 2023-12-12 | 10X Genomics, Inc. | Methods, compositions, and kits for blocking a capture probe on a spatial array |
US11753673B2 (en) | 2021-09-01 | 2023-09-12 | 10X Genomics, Inc. | Methods, compositions, and kits for blocking a capture probe on a spatial array |
Also Published As
Publication number | Publication date |
---|---|
US20110151498A1 (en) | 2011-06-23 |
US20140199713A1 (en) | 2014-07-17 |
US20080274493A1 (en) | 2008-11-06 |
EP1343973B2 (en) | 2020-09-16 |
US20160123958A1 (en) | 2016-05-05 |
US7887753B2 (en) | 2011-02-15 |
EP1343973A1 (en) | 2003-09-17 |
EP2381116A1 (en) | 2011-10-26 |
EP1343973A4 (en) | 2004-12-22 |
US9176137B2 (en) | 2015-11-03 |
US7378280B2 (en) | 2008-05-27 |
US10509018B2 (en) | 2019-12-17 |
AU2002230524A1 (en) | 2002-05-27 |
US8273574B2 (en) | 2012-09-25 |
EP1343973B1 (en) | 2017-11-08 |
US20040115838A1 (en) | 2004-06-17 |
US8455258B2 (en) | 2013-06-04 |
US20110151499A1 (en) | 2011-06-23 |
US8673645B2 (en) | 2014-03-18 |
US20130140181A1 (en) | 2013-06-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US10509018B2 (en) | Apparatus and methods for conducting assays and high throughput screening | |
Dittrich et al. | Micro total analysis systems. Latest advancements and trends | |
Jakeway et al. | Miniaturized total analysis systems for biological analysis | |
US10900896B2 (en) | Flow cells utilizing surface-attached structures, and related systems and methods | |
Kraly et al. | Microfluidic applications in metabolomics and metabolic profiling | |
Weigl et al. | Lab-on-a-chip for drug development | |
Chao et al. | Microfluidic single-cell analysis of intracellular compounds | |
TWI247884B (en) | Microfluidic system utilizing thin-film layers to route fluid | |
US9643136B2 (en) | Microfluidic free interface diffusion techniques | |
US8124015B2 (en) | Multiplexed, microfluidic molecular assay device and assay method | |
Feng et al. | Microfluidic chip: next-generation platform for systems biology | |
WO2002029106A2 (en) | Microfluidic devices and methods of use | |
Qin et al. | Microfluidic devices for the analysis of apoptosis | |
IE20020619A1 (en) | An assay assembly | |
Huang et al. | Integrated microfluidic system for electrochemical sensing of glycosylated hemoglobin | |
US10919036B2 (en) | Flow cells utilizing surface-attached structures, and related systems and methods | |
Kumar et al. | Recent progress on microfluidic electrophoresis device application in mass spectrometry | |
Wang et al. | Surface modification of glass/PDMS microfluidic valve assemblies enhances valve electrical resistance | |
Hadavi et al. | Technological advances for analyzing the content of organ-on-a-chip by mass spectrometry | |
Ahmadi et al. | System integration in microfluidics | |
KR20080113911A (en) | A microelectro-desalting device of protein sample, a lab-on-a-chip comprising said device and an application method thereof | |
Nazim et al. | Application of Micro-Fluidics in Biological World | |
Liu et al. | Microfluidic and Lab-on-Chip Technologies for Biosensors | |
Wang et al. | From biochips to laboratory-on-a-chip system | |
Frankenfeld et al. | Pharmaceutical Analysis Using Bio-MEMS |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PH PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
REEP | Request for entry into the european phase |
Ref document number: 2001990762 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2001990762 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 2001990762 Country of ref document: EP |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
WWE | Wipo information: entry into national phase |
Ref document number: 10416418 Country of ref document: US |
|
NENP | Non-entry into the national phase |
Ref country code: JP |
|
WWW | Wipo information: withdrawn in national office |
Ref document number: JP |
|
DPE2 | Request for preliminary examination filed before expiration of 19th month from priority date (pct application filed from 20040101) |