WO2002043491A1 - Extended duration insect repellent composition and method of application to the skin - Google Patents
Extended duration insect repellent composition and method of application to the skin Download PDFInfo
- Publication number
- WO2002043491A1 WO2002043491A1 PCT/US2001/044299 US0144299W WO0243491A1 WO 2002043491 A1 WO2002043491 A1 WO 2002043491A1 US 0144299 W US0144299 W US 0144299W WO 0243491 A1 WO0243491 A1 WO 0243491A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- composition
- polyurethane
- insect repellent
- urethane polymer
- skin
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 105
- 239000000077 insect repellent Substances 0.000 title claims abstract description 37
- 238000000034 method Methods 0.000 title claims abstract description 9
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- 229920000642 polymer Polymers 0.000 claims abstract description 22
- 241000238631 Hexapoda Species 0.000 claims abstract description 14
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- 239000000516 sunscreening agent Substances 0.000 claims description 11
- 125000004432 carbon atom Chemical group C* 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 239000007921 spray Substances 0.000 claims description 8
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- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 claims description 4
- VZRKEAFHFMSHCD-UHFFFAOYSA-N Ethyl 3-(N-butylacetamido)propionate Chemical compound CCCCN(C(C)=O)CCC(=O)OCC VZRKEAFHFMSHCD-UHFFFAOYSA-N 0.000 claims description 4
- GLZPCOQZEFWAFX-UHFFFAOYSA-N Geraniol Chemical compound CC(C)=CCCC(C)=CCO GLZPCOQZEFWAFX-UHFFFAOYSA-N 0.000 claims description 4
- 125000001931 aliphatic group Chemical group 0.000 claims description 4
- 125000000217 alkyl group Chemical group 0.000 claims description 4
- 125000002947 alkylene group Chemical group 0.000 claims description 4
- 125000003118 aryl group Chemical group 0.000 claims description 4
- 125000004122 cyclic group Chemical group 0.000 claims description 4
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- 239000004814 polyurethane Substances 0.000 claims description 4
- TYYHDKOVFSVWON-UHFFFAOYSA-N 2-butyl-2-methoxy-1,3-diphenylpropane-1,3-dione Chemical compound C=1C=CC=CC=1C(=O)C(OC)(CCCC)C(=O)C1=CC=CC=C1 TYYHDKOVFSVWON-UHFFFAOYSA-N 0.000 claims description 3
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- YBGZDTIWKVFICR-JLHYYAGUSA-N Octyl 4-methoxycinnamic acid Chemical compound CCCCC(CC)COC(=O)\C=C\C1=CC=C(OC)C=C1 YBGZDTIWKVFICR-JLHYYAGUSA-N 0.000 claims description 3
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- QLHULAHOXSSASE-UHFFFAOYSA-N butan-2-yl 2-(2-hydroxyethyl)piperidine-1-carboxylate Chemical compound CCC(C)OC(=O)N1CCCCC1CCO QLHULAHOXSSASE-UHFFFAOYSA-N 0.000 claims description 3
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- CXVGEDCSTKKODG-UHFFFAOYSA-N sulisobenzone Chemical compound C1=C(S(O)(=O)=O)C(OC)=CC(O)=C1C(=O)C1=CC=CC=C1 CXVGEDCSTKKODG-UHFFFAOYSA-N 0.000 claims description 2
- 229960000368 sulisobenzone Drugs 0.000 claims description 2
- UEVAMYPIMMOEFW-UHFFFAOYSA-N trolamine salicylate Chemical compound OCCN(CCO)CCO.OC(=O)C1=CC=CC=C1O UEVAMYPIMMOEFW-UHFFFAOYSA-N 0.000 claims description 2
- IVOYYPHHZOHPQI-UHFFFAOYSA-N 2,3-dioctoxyphenol;2-methoxyphenol;triazine Chemical compound C1=CN=NN=C1.COC1=CC=CC=C1O.CCCCCCCCOC1=CC=CC(O)=C1OCCCCCCCC IVOYYPHHZOHPQI-UHFFFAOYSA-N 0.000 claims 2
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
- A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
- A01N25/06—Aerosols
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/08—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
- A01N25/10—Macromolecular compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Definitions
- the present invention relates to an insect repellent composition. More particularly, the present invention relates to an insect repellent exhibiting extended duration of repellency on the skin. Further, the present invention relates to such a composition exhibiting water, sweat, and wear resistance. As used herein, the term "insect” is intended to mean any insect or arachnid.
- Insect repellent compositions are available commercially in a variety of product forms, such as aerosol and pump sprays, creams, lotions and gels. Depending upon the product form, the compositions may be administered to both the skin and to clothing. The compositions may be administered in preparation for a variety of outdoor situations, such as picnicking, hiking, fishing, swimming and exercise.
- a common problem associated with insect repellent compositions is a lack of duration of repellency. This translates into insufficient repellency and the need to re-apply often. Insect repellent compositions may wash off from exposure to water, sweating and/or physical contact with the skin. It would be desirable to increase the duration of repellency of insect repellent compositions on the skin. It would further be desirable to have insect repellent compositions that resist removal by exposure to water, sweating and physical contact.
- U.S. Patent No. 4,913,897 to Chvapil et al. is directed to hydrogel compositions that form films on the surface of the skin to protect it against exposure to toxic substances and infections. This patent provides that such films may also contain an insect repellent.
- the urethane polymers of the present invention are not hydrogels nor do they form hydrogels in the present invention.
- an insect repellent composition having an amount of an insect repellent active sufficient to repel insects when the composition is applied to the skin.
- the composition also has an amount of urethane polymer sufficient to form a thin, substantially continuous film on the skin.
- the composition also has a cosmetically acceptable vehicle.
- a method of repelling insects from the skin is provided.
- the composition described above is applied to the skin.
- This urethane film is substantially uniform and provides superior coverage over the peaks and valleys of the skin surface, allowing for reduction of unprotected skin areas.
- Figure 1 is a bar graph illustrating the duration of insect repellency with varying levels of urethane polymers.
- Figure 2 is a view of a photograph of showing the topography of an artificial skin substrate without the application of the present invention.
- Figure 3 is a view of a photograph showing the topography of a skin substrate with and without the application of an acrylic polymer not of the present invention.
- Figure 4 is a view of a photograph showing the appearance of a skin substrate with and without the application of the present invention.
- an insect repellent composition can be produced that exhibits extended duration of repellency on the skin, and also enhanced insect repellency.
- the composition has superior spread characteristics on the skin.
- the composition may also exhibit water, sweat and wear resistance.
- the composition can be formulated to be substantially transparent or otherwise aesthetically acceptable to impart a pleasant feel or sensation to the skin.
- the present composition leaves a uniform film on the surface of the skin.
- the composition which exhibits superior spread characteristics, provides more uniform and consistent coverage on the skin.
- the film has been found to maintain the duration of the insect repellent active(s) for a longer period of time than it would otherwise remain without the urethane polymer.
- the film also affords sustained release of the active. Additionally, enhanced resistance to water, sweat, and wear may be observed.
- the film has an enhanced degree of insect repellency for a given amount of insect repellent active employed. Thus, the amount of insect repellent active applied to the skin can be minimized.
- the film-forming component of the present composition is a urethane polymer resin.
- Urethane polymers are formed by reactions of diisocyanate and glycol monomers.
- Preferred urethane polymer resins for use in the present invention are of the following formula:
- R and R' are, independently, any linear or branched alkyl, alkylene, aliphatic or aromatic group having from 1 to about 30 carbon atoms, preferably about 6 to about 24 carbon atoms, and n is an integer from 2 to about 1000.
- R' is cyclic, it preferably contains 6 or more carbon atoms.
- Urethane polymer resins useful in the present invention can be either hydrophobic or hydrophilic.
- urethane polymer resins are those referred to in the art as Polyurethane-1 , Polyurethane-2, Polyurethane-4, Polyurethane-5 or mixtures thereof. These urethane polymer resins are described in the International Cosmetic Ingredient Dictionary and Handbook, 8 th edition, Printed Edition Pages 1152-1153, which is incorporated herein by reference.
- the urethane polymer is present in an amount about 0.1 wt.% to about 20 wt.% based on the total weight of the composition.
- the amount of the urethane polymer is preferably about 0.5 wt.% to about 10 wt.%, and, most preferably, about 1 wt.% to about 5 wt.%, based on the total weight of the composition.
- the insect repellent or insect repellent active employed in the present composition may be any known in the art.
- Such actives include, but are not limited to, N,N diethyl- m-toluamide (DEET), ethyl butylacetylaminopropionate (IR3535 by Merck Co.), hydroxy-ethyl isobutyl piperidine carboxylate (1-piperidinecarboxylic acid) (Bayer KBR 3023), oil of citronella, soy bean oil, lemon grass oil, geranium/geraniol oil, p-menthane-3,8-diol, or mixtures thereof.
- DEET N,N diethyl- m-toluamide
- IR3535 ethyl butylacetylaminopropionate
- hydroxy-ethyl isobutyl piperidine carboxylate (1-piperidinecarboxylic acid) Bayer KBR 3023
- oil of citronella soy bean oil, lemon grass oil, geranium/geraniol oil, p-menthane
- the amount of insect repellent active is about 0.1 wt.% to about 70 wt.% based on the total weight of the composition.
- the amount of insect repellent active is preferably about 0.1 wt.% to about 25 wt.%, and, most preferably, about 5 wt.% to about 25 wt.%, based on the total weight of the composition.
- the present composition may take any form known in the art. Such forms include, but are not limited to, a cream, lotion, gel, solution, ointment, towelette, mousse, stick, or pump spray or aerosol. If an aerosol spray, the composition may contain propellents, such as hydrocarbons, hydrofluorocarbons, chlorofluorocarbons and ethers.
- the composition may be aqueous or anhydrous.
- the composition may further be in an emulsion form.
- the present composition preferably has a vehicle.
- Such vehicles may be any known in the art including, for example, water; vegetable oils; esters such as octyl palmitate, isopropyl myristate and isopropyl palmitate; ethers such as dicapryl ether and dimethyl isosorbide; alcohols such as ethanol and isopropanol; fatty alcohols such as cetyl alcohol, stearyl alcohol and behenyl alcohol; isoparaffins such as isooctane, isododecane and isohexadecane; silicone oils such as cyclomethicone, dimethicone, dimethicone cross-polymers, polysiloxanes and their derivatives, preferably organomodified derivatives; hydrocarbon oils such as mineral oil, petrolatum, isoeicosane and polyisobutene; polyols such as propylene glycol, glycerin, butylene glycol, pentylene glycol and hexylene glycol; waxes
- the present composition may further include a sunscreen.
- the sunscreen may be any sunscreen know in the art. Such sunscreens include, but are not limited to, oxybenzone, sulisobenzone, dioxybenzone,
- the sunscreen is preferably about 1 wt.% to about 45 wt.% of the total weight of the composition.
- the sunscreen is about 2 wt.% to about 35 wt.% of the total weight of the composition.
- the sunscreen protects against both UVA and UVB radiation, and provides a SPF factor of at least about 2 and more preferably at least about 4.
- the preferred range of SPF protection is about 10 to about 50 and most preferably about 15 to about 30.
- the present composition may have one or more of the following additional ingredients: anesthetics, anti-allergenics, antifungals, anti-inflammatories, antiseptics, chelating agents, colorants, depigmenting agents, emollients, emulsifiers, exfollients, fragrances, humectants, lubricants, moisturizers, pharmaceutical agents, preservatives, skin penetration enhancers, stabilizers, surfactants, thickeners, viscosity modifiers, vitamins or any combinations of these ingredients. Examples 1 and 2 and Control
- compositions of the present invention were tested for duration of insect repellency.
- a control composition (“the Control") was likewise tested.
- compositions of Examples 1 and 2 had polyurethane concentrations of 1.0 wt.% and 2.0 wt.%, respectively, based upon the total weight of the compositions.
- the Control did not have any polyurethane (zero wt.%).
- the polyurethane resin employed was Polyurethane-1. All the compositions had 20 wt.% of IR3535 (Merck) as an insect repellent active, and q.s. with a mixture of alcohol and water.
- the duration of insect repellency was tested on five subjects in a cage test utilizing a 1 cubic meter cage containing 200 mosquitoes.
- FIG. 2 shows a 3-dimensional interactive display of the bare substrate as viewed under an optical profiler microscope. The peaks and valleys of the skin surface are clearly pronounced.
- tape was placed over the left side of a substrate sample.
- An insect repellent composition containing a conventional acrylic film forming polymer was applied to the right side of the substrate, allowed to dry and the tape was removed.
- a digital image was taken of this substrate surface using a Wyko NT1000 Optical Profiler made by Vecco.
Abstract
Description
Claims
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
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CA 2393290 CA2393290A1 (en) | 2000-11-28 | 2001-11-27 | Extended duration insect repellent composition and method of application to the skin |
DE2001605389 DE60105389T2 (en) | 2000-11-28 | 2001-11-27 | INSECT-SPRAYING COMPOSITION WITH EXTENDED DURATION AND PROCEDURE FOR APPLYING TO SKIN |
EP20010998225 EP1250043B1 (en) | 2000-11-28 | 2001-11-27 | Extended duration insect repellent composition and method of application to the skin |
US10/203,839 US7150878B2 (en) | 2000-11-28 | 2001-11-27 | Extended duration insect repellent composition and method of application to the skin |
AU2002217888A AU2002217888B2 (en) | 2000-11-28 | 2001-11-27 | Extended duration insect repellent composition and method of application to the skin |
AU1788802A AU1788802A (en) | 2000-11-28 | 2001-11-27 | Extended duration insect repellent composition and method of application to the skin |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US09/724,160 US6719959B1 (en) | 2000-11-28 | 2000-11-28 | Extended duration insect repellent composition and method of application to the skin |
US09/724,160 | 2000-11-28 |
Publications (2)
Publication Number | Publication Date |
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WO2002043491A1 true WO2002043491A1 (en) | 2002-06-06 |
WO2002043491A9 WO2002043491A9 (en) | 2003-08-14 |
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Application Number | Title | Priority Date | Filing Date |
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PCT/US2001/044299 WO2002043491A1 (en) | 2000-11-28 | 2001-11-27 | Extended duration insect repellent composition and method of application to the skin |
Country Status (6)
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US (2) | US6719959B1 (en) |
EP (1) | EP1250043B1 (en) |
AU (2) | AU1788802A (en) |
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Cited By (6)
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EP1213010A2 (en) * | 2000-12-09 | 2002-06-12 | Beiersdorf AG | Use of water-soluble and film-forming polymers for increasing the light protection factor and/or the protection performance to UV-A in cosmetic or dermatological formulations |
EP1762221A1 (en) * | 2005-07-20 | 2007-03-14 | Beiersdorf AG | Insect repellent with long lasting affect |
EP3099381A4 (en) * | 2014-01-28 | 2017-07-19 | Avon Products, Inc. | Extended release fragrance compositions |
US10842729B2 (en) | 2017-09-13 | 2020-11-24 | Living Proof, Inc. | Color protectant compositions |
US10987300B2 (en) | 2017-09-13 | 2021-04-27 | Living Proof, Inc. | Long lasting cosmetic compositions |
US11622929B2 (en) | 2016-03-08 | 2023-04-11 | Living Proof, Inc. | Long lasting cosmetic compositions |
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US6719959B1 (en) * | 2000-11-28 | 2004-04-13 | Avon Products, Inc. | Extended duration insect repellent composition and method of application to the skin |
US20060057084A1 (en) * | 2004-09-14 | 2006-03-16 | Gonzalez Anthony D | Attero-chromic color aggregates |
US20070264294A1 (en) * | 2006-05-10 | 2007-11-15 | Lance-Gomez Edward T | Insect control compositions |
US8114386B2 (en) * | 2006-05-12 | 2012-02-14 | 3M Innovative Properties Company | Topical insect repellent composition and method of application |
US20070298063A1 (en) * | 2006-06-23 | 2007-12-27 | Riannon Walsh | Equine gnat repellant |
US7744911B2 (en) * | 2006-08-25 | 2010-06-29 | Avon Products, Inc | Water based clear sunscreen and insect repellent composition |
WO2009082565A1 (en) | 2007-12-20 | 2009-07-02 | Avon Products, Inc. | Cosmetic compositions for imparting superhydrophobic films |
CN101980686A (en) * | 2008-03-04 | 2011-02-23 | 雅芳产品公司 | Cosmetic compositions for imparting superhydrophobic fimls |
US8747875B2 (en) * | 2008-09-29 | 2014-06-10 | The Hartz Mountain Corporation | Photo-stable pest control |
CN102596152A (en) * | 2009-11-06 | 2012-07-18 | 雅芳产品公司 | Methods and compositions for preventing or reducing frizzy appearance of hair |
ES2646862T3 (en) | 2009-11-06 | 2017-12-18 | Avon Products, Inc. | Methods and compositions to prevent or reduce the curly appearance of hair |
EP2324819B1 (en) * | 2009-11-19 | 2015-07-08 | L'Oréal | Coloured perfume composition comprising a hydrophilic UVA filter without alkyl diphenylacrylate |
US9956432B2 (en) | 2010-11-05 | 2018-05-01 | Avon Products, Inc. | Method for improving color retention in artificially colored hair |
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US10052277B2 (en) | 2014-01-28 | 2018-08-21 | Avon Products, Inc. | Extended release fragrance compositions |
US11622929B2 (en) | 2016-03-08 | 2023-04-11 | Living Proof, Inc. | Long lasting cosmetic compositions |
US10842729B2 (en) | 2017-09-13 | 2020-11-24 | Living Proof, Inc. | Color protectant compositions |
US10987300B2 (en) | 2017-09-13 | 2021-04-27 | Living Proof, Inc. | Long lasting cosmetic compositions |
US11707426B2 (en) | 2017-09-13 | 2023-07-25 | Living Proof, Inc. | Color protectant compositions |
Also Published As
Publication number | Publication date |
---|---|
AU1788802A (en) | 2002-06-11 |
CA2393290A1 (en) | 2002-06-06 |
US7150878B2 (en) | 2006-12-19 |
US20030099679A1 (en) | 2003-05-29 |
DE60105389T2 (en) | 2005-09-22 |
WO2002043491A9 (en) | 2003-08-14 |
EP1250043B1 (en) | 2004-09-08 |
US6719959B1 (en) | 2004-04-13 |
AU2002217888B2 (en) | 2006-11-16 |
EP1250043A1 (en) | 2002-10-23 |
EP1250043A4 (en) | 2003-04-02 |
DE60105389D1 (en) | 2004-10-14 |
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