WO2002043584A3 - Method and apparatus for measurement of mean pulmonary artery pressure form a ventricle in an ambulatory monitor - Google Patents

Method and apparatus for measurement of mean pulmonary artery pressure form a ventricle in an ambulatory monitor Download PDF

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Publication number
WO2002043584A3
WO2002043584A3 PCT/US2001/044978 US0144978W WO0243584A3 WO 2002043584 A3 WO2002043584 A3 WO 2002043584A3 US 0144978 W US0144978 W US 0144978W WO 0243584 A3 WO0243584 A3 WO 0243584A3
Authority
WO
WIPO (PCT)
Prior art keywords
pressure
ventricle
mean pulmonary
pulmonary artery
measurement
Prior art date
Application number
PCT/US2001/044978
Other languages
French (fr)
Other versions
WO2002043584A2 (en
WO2002043584A9 (en
Inventor
Lawrence J Mulligan
Tom D Bennett
Original Assignee
Medtronic Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medtronic Inc filed Critical Medtronic Inc
Priority to JP2002545570A priority Critical patent/JP3959025B2/en
Priority to EP01996019A priority patent/EP1341439B1/en
Priority to DE60106645T priority patent/DE60106645T2/en
Priority to CA002430748A priority patent/CA2430748A1/en
Publication of WO2002043584A2 publication Critical patent/WO2002043584A2/en
Publication of WO2002043584A3 publication Critical patent/WO2002043584A3/en
Publication of WO2002043584A9 publication Critical patent/WO2002043584A9/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/0205—Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/021—Measuring pressure in heart or blood vessels
    • A61B5/0215—Measuring pressure in heart or blood vessels by means inserted into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
    • A61B5/0004—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by the type of physiological signal transmitted
    • A61B5/0006—ECG or EEG signals

Abstract

A system and method for determining mean pulmonary arterial pressure (MPAP) using a pressure sensor (16) located within a ventricle of a heart, and a signal indicative of cardiac electrical activity such as an electrocardiogram (EGM) signal. The pressure may be sensed within the right and/or left ventricle using an implanted pressure sensor (16). The sensed pressure may be used to determine the Ventricular Systolic Pressure (VSP) and an estimated Pulmonary Arterial diastolic pressure (ePAD). The VSP, ePAD, and time intervals associated with systole and diastole may then be used to obtain an MPAP that closely approximates mean pulmonary arterial measured using a sensor located in the pulmonary artery.
PCT/US2001/044978 2000-12-01 2001-11-30 Method and apparatus for measurement of mean pulmonary artery pressure form a ventricle in an ambulatory monitor WO2002043584A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2002545570A JP3959025B2 (en) 2000-12-01 2001-11-30 Method and apparatus for determining mean pulmonary artery pressure
EP01996019A EP1341439B1 (en) 2000-12-01 2001-11-30 Apparatus for measurement of mean pulmonary artery pressure from a ventricle in an ambulatory monitor
DE60106645T DE60106645T2 (en) 2000-12-01 2001-11-30 APPARATUS FOR MEASURING THE MEDIUM BLOOD PRESSURE IN THE LUNG ARTERY FROM THE HEART CHAMBER WITH A MOBILE MONITORING DEVICE
CA002430748A CA2430748A1 (en) 2000-12-01 2001-11-30 Method and apparatus for measurement of mean pulmonary artery pressure form a ventricle in an ambulatory monitor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25042000P 2000-12-01 2000-12-01
US60/250,420 2000-12-01

Publications (3)

Publication Number Publication Date
WO2002043584A2 WO2002043584A2 (en) 2002-06-06
WO2002043584A3 true WO2002043584A3 (en) 2003-01-09
WO2002043584A9 WO2002043584A9 (en) 2004-05-06

Family

ID=22947664

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/044978 WO2002043584A2 (en) 2000-12-01 2001-11-30 Method and apparatus for measurement of mean pulmonary artery pressure form a ventricle in an ambulatory monitor

Country Status (6)

Country Link
US (1) US6865419B2 (en)
EP (1) EP1341439B1 (en)
JP (1) JP3959025B2 (en)
CA (1) CA2430748A1 (en)
DE (1) DE60106645T2 (en)
WO (1) WO2002043584A2 (en)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030036746A1 (en) 2001-08-16 2003-02-20 Avi Penner Devices for intrabody delivery of molecules and systems and methods utilizing same
US7024248B2 (en) * 2000-10-16 2006-04-04 Remon Medical Technologies Ltd Systems and methods for communicating with implantable devices
US6666826B2 (en) * 2002-01-04 2003-12-23 Cardiac Pacemakers, Inc. Method and apparatus for measuring left ventricular pressure
US7468032B2 (en) 2002-12-18 2008-12-23 Cardiac Pacemakers, Inc. Advanced patient management for identifying, displaying and assisting with correlating health-related data
US20040122296A1 (en) * 2002-12-18 2004-06-24 John Hatlestad Advanced patient management for triaging health-related data
US20040122487A1 (en) 2002-12-18 2004-06-24 John Hatlestad Advanced patient management with composite parameter indices
US8043213B2 (en) 2002-12-18 2011-10-25 Cardiac Pacemakers, Inc. Advanced patient management for triaging health-related data using color codes
US20040122294A1 (en) 2002-12-18 2004-06-24 John Hatlestad Advanced patient management with environmental data
US7983759B2 (en) 2002-12-18 2011-07-19 Cardiac Pacemakers, Inc. Advanced patient management for reporting multiple health-related parameters
US8391989B2 (en) 2002-12-18 2013-03-05 Cardiac Pacemakers, Inc. Advanced patient management for defining, identifying and using predetermined health-related events
US6986741B2 (en) * 2002-04-08 2006-01-17 Medwave, Inc. Method for measurement of systolic and diastolic time intervals
SE0202214D0 (en) * 2002-07-12 2002-07-12 St Jude Medical A cardiac stimulating device
US7378955B2 (en) * 2003-01-03 2008-05-27 Cardiac Pacemakers, Inc. System and method for correlating biometric trends with a related temporal event
US20040172081A1 (en) * 2003-02-28 2004-09-02 Dai-Yuan Wang Intracardiac pressure guided pacemaker
US20060212081A1 (en) * 2003-07-10 2006-09-21 Jms Co., Ltd. Pacemaker system for treating sleep apnea syndrome
US7662101B2 (en) * 2003-09-18 2010-02-16 Cardiac Pacemakers, Inc. Therapy control based on cardiopulmonary status
US20060064134A1 (en) * 2004-09-17 2006-03-23 Cardiac Pacemakers, Inc. Systems and methods for deriving relative physiologic measurements
US8271093B2 (en) * 2004-09-17 2012-09-18 Cardiac Pacemakers, Inc. Systems and methods for deriving relative physiologic measurements using a backend computing system
US7813808B1 (en) 2004-11-24 2010-10-12 Remon Medical Technologies Ltd Implanted sensor system with optimized operational and sensing parameters
US8594790B2 (en) * 2005-01-27 2013-11-26 Medtronic, Inc. System and method for monitoring a ventricular pressure index to predict worsening heart failure
US20060167361A1 (en) * 2005-01-27 2006-07-27 Bennett Tommy D Method and apparatus for continuous pulse contour cardiac output
US7437192B2 (en) * 2005-04-05 2008-10-14 Pacesetter, Inc. System and method for detecting heart failure and pulmonary edema based on ventricular end-diastolic pressure using an implantable medical device
US20070027489A1 (en) * 2005-07-28 2007-02-01 Jong Gill Characterization of a patient's condition by evaluating electrical and mechanical properties of the heart
GB2428977A (en) * 2005-08-08 2007-02-14 Ai Semi Ltd Pacemaker or defibrillator using combined electrogram and haemodynamic data
US7803121B2 (en) * 2005-08-22 2010-09-28 Scisense Inc. Implant transmitter
US7742815B2 (en) * 2005-09-09 2010-06-22 Cardiac Pacemakers, Inc. Using implanted sensors for feedback control of implanted medical devices
US7488291B2 (en) * 2005-09-28 2009-02-10 Medtronic, Inc. Methods for detecting and monitoring sleep disordered breathing using an implantable medical device
US7566308B2 (en) * 2005-10-13 2009-07-28 Cardiac Pacemakers, Inc. Method and apparatus for pulmonary artery pressure signal isolation
US7636600B1 (en) * 2005-10-21 2009-12-22 Pacesetter, Inc. Pressure monitoring for apnea prevention and/or therapy
US20070142727A1 (en) * 2005-12-15 2007-06-21 Cardiac Pacemakers, Inc. System and method for analyzing cardiovascular pressure measurements made within a human body
US7937137B2 (en) * 2006-01-30 2011-05-03 Medtronic, Inc. Methods of identifying and/or assessing cardiac arrhythmias using an implantable medical device
US20070252836A1 (en) * 2006-04-28 2007-11-01 General Electric Company Region of interest selector
US7678058B2 (en) * 2006-06-22 2010-03-16 Cardiac Pacemakers, Inc. Apnea type determining apparatus and method
US8360983B2 (en) 2006-06-22 2013-01-29 Cardiac Pacemakers, Inc. Apnea type determining apparatus and method
US7955268B2 (en) * 2006-07-21 2011-06-07 Cardiac Pacemakers, Inc. Multiple sensor deployment
US20080077440A1 (en) * 2006-09-26 2008-03-27 Remon Medical Technologies, Ltd Drug dispenser responsive to physiological parameters
US8540642B2 (en) * 2007-01-31 2013-09-24 Medtronic, Inc. Implantable medical device and method for physiological event monitoring
MX2009010000A (en) 2007-03-19 2010-03-17 Insuline Medical Ltd Drug delivery device.
WO2009081262A1 (en) 2007-12-18 2009-07-02 Insuline Medical Ltd. Drug delivery device with sensor for closed-loop operation
US9220837B2 (en) 2007-03-19 2015-12-29 Insuline Medical Ltd. Method and device for drug delivery
US8622991B2 (en) 2007-03-19 2014-01-07 Insuline Medical Ltd. Method and device for drug delivery
US20080243007A1 (en) * 2007-03-28 2008-10-02 Cardiac Pacemakers, Inc. Pulmonary Artery Pressure Signals And Methods of Using
US20080243016A1 (en) * 2007-03-28 2008-10-02 Cardiac Pacemakers, Inc. Pulmonary Artery Pressure Signals And Methods of Using
US20080288013A1 (en) * 2007-04-11 2008-11-20 Pacesetter, Inc. Pulmonary pressure monitoring
US7693576B1 (en) 2007-04-11 2010-04-06 Pacesetter, Inc. Capacitor-integrated feedthrough assembly for an implantable medical device
EP2155051A1 (en) * 2007-06-14 2010-02-24 Cardiac Pacemakers, Inc. Intracorporeal pressure measurement devices and methods
US8027724B2 (en) * 2007-08-03 2011-09-27 Cardiac Pacemakers, Inc. Hypertension diagnosis and therapy using pressure sensor
WO2009041867A1 (en) * 2007-09-24 2009-04-02 St. Jude Medical Ab Medical device for detecting pulmonary artery pressure
JP5211177B2 (en) * 2008-02-11 2013-06-12 カーディアック ペースメイカーズ， インコーポレイテッド Hemodynamic monitoring method for rhythm discrimination in the heart
WO2009102640A1 (en) * 2008-02-12 2009-08-20 Cardiac Pacemakers, Inc. Systems and methods for controlling wireless signal transfers between ultrasound-enabled medical devices
US8211028B2 (en) 2008-04-30 2012-07-03 Medtronic, Inc. System and method of determining arterial blood pressure and ventricular fill parameters from ventricular blood pressure waveform data
US7945324B2 (en) * 2008-06-30 2011-05-17 Data Sciences International, Inc. Pressure sensing lead systems for implantable stimulators
US20100057046A1 (en) * 2008-09-03 2010-03-04 Keimar, Inc Systems for characterizing physiologic parameters and methods for use therewith
JP5465252B2 (en) * 2008-10-10 2014-04-09 カーディアック ペースメイカーズ， インコーポレイテッド System and method for determining cardiac output using pulmonary artery pressure measurements
US8062227B2 (en) * 2008-10-30 2011-11-22 Medtronic, Inc. Heart failure decompensation determination
US20100113943A1 (en) * 2008-10-31 2010-05-06 Burnes John E System and method for simultaneous central and brachial arterial pressure monitoring
US8777850B2 (en) 2008-10-31 2014-07-15 Medtronic, Inc. Heart failure patient management using an implantable monitoring system
BRPI0916125A2 (en) 2008-11-07 2015-11-03 Insuline Medical Ltd "treatment device"
US8632470B2 (en) * 2008-11-19 2014-01-21 Cardiac Pacemakers, Inc. Assessment of pulmonary vascular resistance via pulmonary artery pressure
US9370654B2 (en) 2009-01-27 2016-06-21 Medtronic, Inc. High frequency stimulation to block laryngeal stimulation during vagal nerve stimulation
JP2012525952A (en) * 2009-06-03 2012-10-25 カーディアック ペースメイカーズ， インコーポレイテッド System and method for monitoring cardiovascular pressure
US20100324378A1 (en) * 2009-06-17 2010-12-23 Tran Binh C Physiologic signal monitoring using ultrasound signals from implanted devices
US20110034812A1 (en) * 2009-08-10 2011-02-10 Abhilash Patangay Pulmonary artery pressure based systolic timing intervals as a measure of right ventricular systolic performance
US8585604B2 (en) 2010-10-29 2013-11-19 Medtronic, Inc. Integrated patient care
LT2840955T (en) * 2012-04-23 2024-02-26 Precordior Oy Method and apparatus for determining information indicative of cardiac malfunctions and abnormalities
EP3536230B1 (en) * 2014-08-27 2022-03-16 St. Jude Medical Systems AB System for evaluating a cardiac system by determining minimum ratio pd/pa (distal pressure / arterial pressure)
US11311200B1 (en) 2014-08-27 2022-04-26 Lightlab Imaging, Inc. Systems and methods to measure physiological flow in coronary arteries
US20170105635A1 (en) 2015-10-16 2017-04-20 Medtronic, Inc. Intracardiac medical device with pressure sensing
US11515291B2 (en) 2018-08-28 2022-11-29 Adeia Semiconductor Inc. Integrated voltage regulator and passive components

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4532931A (en) * 1984-06-29 1985-08-06 Cardiac Pacemakers, Inc. Pacemaker with adaptive sensing means for use with unipolar or bipolar leads
US4667680A (en) * 1983-11-14 1987-05-26 Hewlett-Packard Company Apparatus and method for reduction in respiration artifact in pulmonary artery pressure measurement
US4984572A (en) * 1988-08-18 1991-01-15 Leonard Bloom Hemodynamically responsive system for and method of treating a malfunctioning heart
US6113548A (en) * 1997-02-11 2000-09-05 Deboisblanc; Bennet P. Method and apparatus for estimation of beat-to-beat pulmonary wedge pressure

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4958632A (en) * 1978-07-20 1990-09-25 Medtronic, Inc. Adaptable, digital computer controlled cardiac pacemaker
US4310000A (en) * 1980-01-23 1982-01-12 Medtronic, Inc. Implantable pulse generator having separate passive sensing reference electrode
US4407288B1 (en) * 1981-02-18 2000-09-19 Mieczyslaw Mirowski Implantable heart stimulator and stimulation method
US4428378A (en) * 1981-11-19 1984-01-31 Medtronic, Inc. Rate adaptive pacer
US4821723A (en) * 1987-02-27 1989-04-18 Intermedics Inc. Biphasic waveforms for defibrillation
US4865036A (en) * 1988-06-10 1989-09-12 Raul Chirife Antitachyarrythmia pacemaker using pre-ejection period to distinguish physiologic from pathologic tachycardia
US4967747A (en) * 1989-05-19 1990-11-06 Ventritex, Inc. Implantable cardiac defibrillator employing a switched capacitor gain/filter stage having a transient-free gain change
US5226413A (en) * 1990-08-14 1993-07-13 Medtronic, Inc. Rate responsive pacemaker and method for automatically initializing the same
US5158078A (en) * 1990-08-14 1992-10-27 Medtronic, Inc. Rate responsive pacemaker and methods for optimizing its operation
US5195535A (en) * 1990-11-09 1993-03-23 C. R. Bard, Inc. Detachable guidewire extension
US5176137A (en) * 1991-03-01 1993-01-05 Medtronic, Inc. Apparatus for discrimination of stable and unstable ventricular tachycardia and for treatment thereof
CA2106378A1 (en) * 1991-04-05 1992-10-06 Tom D. Bennett Subcutaneous multi-electrode sensing system
US5209229A (en) * 1991-05-20 1993-05-11 Telectronics Pacing Systems, Inc. Apparatus and method employing plural electrode configurations for cardioversion of atrial fibrillation in an arrhythmia control system
US5330505A (en) * 1992-05-08 1994-07-19 Leonard Bloom System for and method of treating a malfunctioning heart
US5312453A (en) * 1992-05-11 1994-05-17 Medtronic, Inc. Rate responsive cardiac pacemaker and method for work-modulating pacing rate deceleration
JP2921287B2 (en) * 1992-08-31 1999-07-19 トヨタ自動車株式会社 Intake device for internal combustion engine
US5353800A (en) * 1992-12-11 1994-10-11 Medtronic, Inc. Implantable pressure sensor lead
US5314430A (en) * 1993-06-24 1994-05-24 Medtronic, Inc. Atrial defibrillator employing transvenous and subcutaneous electrodes and method of use
US5368040A (en) * 1993-08-02 1994-11-29 Medtronic, Inc. Apparatus and method for determining a plurality of hemodynamic variables from a single, chroniclaly implanted absolute pressure sensor
US5544661A (en) * 1994-01-13 1996-08-13 Charles L. Davis Real time ambulatory patient monitor
AU4760196A (en) * 1995-02-27 1996-09-18 Medtronic, Inc. External patient reference sensor
US5564434A (en) * 1995-02-27 1996-10-15 Medtronic, Inc. Implantable capacitive absolute pressure and temperature sensor
US5535752A (en) * 1995-02-27 1996-07-16 Medtronic, Inc. Implantable capacitive absolute pressure and temperature monitor system
US5662688A (en) * 1995-08-14 1997-09-02 Cardiac Pacemakers, Inc. Slow gain control
US5855893A (en) * 1997-02-14 1999-01-05 Elizabeth Arden Co., Division Of Conopco, Inc. Trichodesma lanicum seed extract as an anti-irritant in compositions containing hydroxy acids or retinoids
US6070100A (en) * 1997-12-15 2000-05-30 Medtronic Inc. Pacing system for optimizing cardiac output and determining heart condition
US5902324A (en) * 1998-04-28 1999-05-11 Medtronic, Inc. Bi-atrial and/or bi-ventricular sequential cardiac pacing systems
US6122545A (en) * 1998-04-28 2000-09-19 Medtronic, Inc. Multiple channel sequential cardiac pacing method

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4667680A (en) * 1983-11-14 1987-05-26 Hewlett-Packard Company Apparatus and method for reduction in respiration artifact in pulmonary artery pressure measurement
US4532931A (en) * 1984-06-29 1985-08-06 Cardiac Pacemakers, Inc. Pacemaker with adaptive sensing means for use with unipolar or bipolar leads
US4984572A (en) * 1988-08-18 1991-01-15 Leonard Bloom Hemodynamically responsive system for and method of treating a malfunctioning heart
US6113548A (en) * 1997-02-11 2000-09-05 Deboisblanc; Bennet P. Method and apparatus for estimation of beat-to-beat pulmonary wedge pressure

Also Published As

Publication number Publication date
DE60106645T2 (en) 2005-03-24
JP3959025B2 (en) 2007-08-15
US20020103442A1 (en) 2002-08-01
WO2002043584A2 (en) 2002-06-06
EP1341439A2 (en) 2003-09-10
JP2004538035A (en) 2004-12-24
DE60106645D1 (en) 2004-11-25
WO2002043584A9 (en) 2004-05-06
EP1341439B1 (en) 2004-10-20
CA2430748A1 (en) 2002-06-06
US6865419B2 (en) 2005-03-08

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