WO2002046373A8 - Method of collecting placental stem cells - Google Patents

Method of collecting placental stem cells

Info

Publication number
WO2002046373A8
WO2002046373A8 PCT/US2001/046506 US0146506W WO0246373A8 WO 2002046373 A8 WO2002046373 A8 WO 2002046373A8 US 0146506 W US0146506 W US 0146506W WO 0246373 A8 WO0246373 A8 WO 0246373A8
Authority
WO
WIPO (PCT)
Prior art keywords
cells
stem cells
collecting
residual
placental stem
Prior art date
Application number
PCT/US2001/046506
Other languages
French (fr)
Other versions
WO2002046373A9 (en
WO2002046373A1 (en
Inventor
Robert J Hariri
Original Assignee
Robert J Hariri
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to KR1020037007561A priority Critical patent/KR100915482B1/en
Priority to DK01999637.0T priority patent/DK1349918T3/en
Priority to EP01999637.0A priority patent/EP1349918B1/en
Priority to JP2002548091A priority patent/JP4294316B2/en
Priority to AU2020902A priority patent/AU2020902A/en
Priority to ES01999637.0T priority patent/ES2522890T3/en
Priority to MXPA03005014A priority patent/MXPA03005014A/en
Priority to EP10183378.8A priority patent/EP2305795B1/en
Application filed by Robert J Hariri filed Critical Robert J Hariri
Priority to IL15630301A priority patent/IL156303A0/en
Priority to AU2002220209A priority patent/AU2002220209B2/en
Priority to CA002430989A priority patent/CA2430989A1/en
Publication of WO2002046373A1 publication Critical patent/WO2002046373A1/en
Publication of WO2002046373A8 publication Critical patent/WO2002046373A8/en
Publication of WO2002046373A9 publication Critical patent/WO2002046373A9/en
Priority to IL156303A priority patent/IL156303A/en
Priority to IL208510A priority patent/IL208510A/en
Priority to IL213109A priority patent/IL213109A/en

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0605—Cells from extra-embryonic tissues, e.g. placenta, amnion, yolk sac, Wharton's jelly
    • C—CHEMISTRY; METALLURGY
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • A61K35/50—Placenta; Placental stem cells; Amniotic fluid; Amnion; Amniotic stem cells
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10—Perfusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/04—Cell isolation or sorting
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
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    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0668—Mesenchymal stem cells from other natural sources
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0413—Blood
    • A61M2202/0462—Placental blood, umbilical cord blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/14—Female reproductive, genital organs
    • A61M2210/1433—Uterus
    • A61M2210/1458—Placenta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/14—Female reproductive, genital organs
    • A61M2210/1433—Uterus
    • A61M2210/1466—Umbilical cord
    • C—CHEMISTRY; METALLURGY
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    • C12N2509/00—Methods for the dissociation of cells, e.g. specific use of enzymes
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    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue

Abstract

A method of collecting embryonic-like stem cells from a placenta which has been treated to remove residual cord blood by perfusing the drained placenta with an anticoagulant solution to flush out residual cells, collecting the residual cells and perfusion liquid from the drained placenta, and separating the embryonic-like cells from the residual cells and perfusion liquid. Exogenous cells can be propagated in the placental bioreactor and bioactive molecules collected therefrom.
PCT/US2001/046506 2000-12-06 2001-12-05 Method of collecting placental stem cells WO2002046373A1 (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
IL15630301A IL156303A0 (en) 2000-12-06 2001-12-05 Method of collecting placental stem cells
DK01999637.0T DK1349918T3 (en) 2000-12-06 2001-12-05 Method of collecting stem cells from placenta
AU2002220209A AU2002220209B2 (en) 2000-12-06 2001-12-05 Method of collecting placental stem cells
AU2020902A AU2020902A (en) 2000-12-06 2001-12-05 Method of collecting placental stem cells background of the invention
ES01999637.0T ES2522890T3 (en) 2000-12-06 2001-12-05 Method to collect placental stem cells
MXPA03005014A MXPA03005014A (en) 2000-12-06 2001-12-05 Method of collecting placental stem cells.
EP10183378.8A EP2305795B1 (en) 2000-12-06 2001-12-05 Method of collecting placental stem cells
KR1020037007561A KR100915482B1 (en) 2000-12-06 2001-12-05 Method of collecting placental stem cells
EP01999637.0A EP1349918B1 (en) 2000-12-06 2001-12-05 Method of collecting placental stem cells
JP2002548091A JP4294316B2 (en) 2000-12-06 2001-12-05 Method for collecting placental stem cells
CA002430989A CA2430989A1 (en) 2000-12-06 2001-12-05 Method of collecting placental stem cells
IL156303A IL156303A (en) 2000-12-06 2003-06-04 Method of collecting placental stem cells from a post-partum human placenta
IL208510A IL208510A (en) 2000-12-06 2010-10-06 Isolated nucleated placental cell population
IL213109A IL213109A (en) 2000-12-06 2011-05-24 Method of propagating exogenous cells in a placental bioreactor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25190000P 2000-12-06 2000-12-06
US60/251,900 2000-12-06

Publications (3)

Publication Number Publication Date
WO2002046373A1 WO2002046373A1 (en) 2002-06-13
WO2002046373A8 true WO2002046373A8 (en) 2002-10-10
WO2002046373A9 WO2002046373A9 (en) 2003-01-09

Family

ID=22953866

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/046506 WO2002046373A1 (en) 2000-12-06 2001-12-05 Method of collecting placental stem cells

Country Status (13)

Country Link
US (13) US7045148B2 (en)
EP (5) EP3299452A1 (en)
JP (1) JP4294316B2 (en)
KR (2) KR100915482B1 (en)
AU (2) AU2020902A (en)
CA (2) CA2678490A1 (en)
DK (1) DK1349918T3 (en)
ES (1) ES2522890T3 (en)
HK (1) HK1252977A1 (en)
IL (4) IL156303A0 (en)
MX (1) MXPA03005014A (en)
WO (1) WO2002046373A1 (en)
ZA (1) ZA200304341B (en)

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MXPA01007820A (en) * 1999-02-04 2003-06-19 Technion Res & Dev Foundation Method and apparatus for maintenance and expansion of hemopoietic stem cells and/or progenitor cells.
US10638734B2 (en) * 2004-01-05 2020-05-05 Abt Holding Company Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof
US7015037B1 (en) * 1999-08-05 2006-03-21 Regents Of The University Of Minnesota Multiponent adult stem cells and methods for isolation
US8609412B2 (en) * 1999-08-05 2013-12-17 Regents Of The University Of Minnesota Mapc generation of lung tissue
US7311905B2 (en) * 2002-02-13 2007-12-25 Anthrogenesis Corporation Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells
KR100915482B1 (en) 2000-12-06 2009-09-03 하리리 로버트 제이 Method of collecting placental stem cells
US20080152629A1 (en) * 2000-12-06 2008-06-26 James Edinger Placental stem cell populations
NZ528035A (en) * 2001-02-14 2005-07-29 Robert J Hariri Renovation and repopulation of decellularized tissues and cadaveric organs by stem cells
EP1367899A4 (en) * 2001-02-14 2004-07-28 Leo T Furcht Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof
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