WO2002049512A3 - Imaging system for obtaining quantative perfusion indices - Google Patents

Imaging system for obtaining quantative perfusion indices Download PDF

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Publication number
WO2002049512A3
WO2002049512A3 PCT/US2001/043786 US0143786W WO0249512A3 WO 2002049512 A3 WO2002049512 A3 WO 2002049512A3 US 0143786 W US0143786 W US 0143786W WO 0249512 A3 WO0249512 A3 WO 0249512A3
Authority
WO
WIPO (PCT)
Prior art keywords
mri
quantative
obtaining
imaging system
function
Prior art date
Application number
PCT/US2001/043786
Other languages
French (fr)
Other versions
WO2002049512A8 (en
WO2002049512A2 (en
Inventor
Lee H Schwamm
Gregory A Sorensen
Original Assignee
Gen Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gen Hospital Corp filed Critical Gen Hospital Corp
Priority to AU2002239311A priority Critical patent/AU2002239311A1/en
Publication of WO2002049512A2 publication Critical patent/WO2002049512A2/en
Publication of WO2002049512A3 publication Critical patent/WO2002049512A3/en
Publication of WO2002049512A8 publication Critical patent/WO2002049512A8/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/026—Measuring blood flow
    • A61B5/0275—Measuring blood flow using tracers, e.g. dye dilution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/026—Measuring blood flow
    • A61B5/0263—Measuring blood flow using NMR
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/40—Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4058—Detecting, measuring or recording for evaluating the nervous system for evaluating the central nervous system
    • A61B5/4064—Evaluating the brain

Abstract

A bolus containing optical and MRI contrast agents is administered to a patient for determining quantitative perfusion indices from perfusion weighted magnetic resonance imaging analysis (PWI). The optical contrast agent time-concentration data, which can be obtained non-invasively, is used to define an arterial input function. The MRI contrast agent time concentration can be non-invasively determined using MRI to define a tissue function. An MRI time-signal curve can be determined by deconvolving the arterial and tissue functions. In one embodiment, SVD is used to determine a residue function from which a flow map can be computed.
PCT/US2001/043786 2000-12-18 2001-11-06 Imaging system for obtaining quantative perfusion indices WO2002049512A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002239311A AU2002239311A1 (en) 2000-12-18 2001-11-06 Imaging system for obtaining quantative perfusion indices

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/739,194 2000-12-18
US09/739,194 US6542769B2 (en) 2000-12-18 2000-12-18 Imaging system for obtaining quantative perfusion indices

Publications (3)

Publication Number Publication Date
WO2002049512A2 WO2002049512A2 (en) 2002-06-27
WO2002049512A3 true WO2002049512A3 (en) 2003-01-30
WO2002049512A8 WO2002049512A8 (en) 2003-05-22

Family

ID=24971218

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/043786 WO2002049512A2 (en) 2000-12-18 2001-11-06 Imaging system for obtaining quantative perfusion indices

Country Status (3)

Country Link
US (1) US6542769B2 (en)
AU (1) AU2002239311A1 (en)
WO (1) WO2002049512A2 (en)

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US8337444B2 (en) * 2001-05-22 2012-12-25 Alfred E. Mann Institute For Biomedical Engineering At The University Of Southern California Measurement of cardiac output and blood volume by non-invasive detection of indicator dilution for hemodialysis
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KR100973183B1 (en) 2008-10-29 2010-07-30 한국과학기술원 Analysis Apparatus For Perfusion Rate And Method For The Same
JP5311333B2 (en) * 2008-10-31 2013-10-09 ジーイー・メディカル・システムズ・グローバル・テクノロジー・カンパニー・エルエルシー Blood flow dynamic analysis apparatus and magnetic resonance imaging apparatus
US8718747B2 (en) * 2010-04-16 2014-05-06 Oslo Universitetssykehus Hf Estimating and correcting for contrast agent extravasation in tissue perfusion imaging
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CN108095687A (en) * 2012-05-18 2018-06-01 古斯塔夫·鲁西Igr研究所 Using red and remote red fluorescent dye biological tissue is characterized in cell grade
DE102012209410B4 (en) * 2012-06-04 2020-08-13 Siemens Healthcare Gmbh Determination of a patient-specific contrast agent impulse response function as well as prediction of an expected contrast agent curve based on it and control of a medical imaging system
US10426361B2 (en) * 2013-06-14 2019-10-01 Novadaq Technologies ULC Quantification of absolute blood flow in tissue using fluorescence-mediated photoplethysmography
JP6338849B2 (en) * 2013-12-11 2018-06-06 キヤノンメディカルシステムズ株式会社 Image analysis apparatus and X-ray diagnostic apparatus
FR3027115B1 (en) * 2014-10-13 2019-05-10 Olea Medical SYSTEM AND METHOD FOR ESTIMATING A QUANTITY OF INTEREST IN AN ARTERY / FABRIC / VEIN DYNAMIC SYSTEM
CA3053274A1 (en) 2016-02-16 2017-08-24 Novadaq Technologies ULC Facilitating assessment of blood flow and tissue perfusion using fluorescence-mediated photoplethysmography
CN109726752A (en) * 2018-12-25 2019-05-07 脑玺(上海)智能科技有限公司 The dividing method and system of perfusion dynamic image based on time signal curve

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Also Published As

Publication number Publication date
WO2002049512A8 (en) 2003-05-22
US20020111550A1 (en) 2002-08-15
WO2002049512A2 (en) 2002-06-27
US6542769B2 (en) 2003-04-01
AU2002239311A1 (en) 2002-07-01

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