WO2002049669A3 - Electrically responsive promoter system - Google Patents

Electrically responsive promoter system Download PDF

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Publication number
WO2002049669A3
WO2002049669A3 PCT/US2001/049845 US0149845W WO0249669A3 WO 2002049669 A3 WO2002049669 A3 WO 2002049669A3 US 0149845 W US0149845 W US 0149845W WO 0249669 A3 WO0249669 A3 WO 0249669A3
Authority
WO
WIPO (PCT)
Prior art keywords
responsive promoter
electrically responsive
promoter system
sequence
involves
Prior art date
Application number
PCT/US2001/049845
Other languages
French (fr)
Other versions
WO2002049669A2 (en
Inventor
Carl A Schu
Rodolfo Padua
Mathew Bonner
Maura G Donovan
Orhan Soykan
Original Assignee
Medtronic Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medtronic Inc filed Critical Medtronic Inc
Priority to EP01992274A priority Critical patent/EP1352073A2/en
Priority to JP2002551007A priority patent/JP2004516274A/en
Priority to CA002432310A priority patent/CA2432310A1/en
Priority to AU2002232736A priority patent/AU2002232736A1/en
Publication of WO2002049669A2 publication Critical patent/WO2002049669A2/en
Publication of WO2002049669A3 publication Critical patent/WO2002049669A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6957—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a device or a kit, e.g. stents or microdevices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Abstract

The present invention provides methods and systems for regulating delivery of therapeutic proteins and nucleic acids. Specifically, this involves using a genetically engineered electrically responsive promoter operably linked to a therapeutic gene sequence, wherein expression of said sequence is controlled by an electrical pulse generator.
PCT/US2001/049845 2000-12-21 2001-12-20 Electrically responsive promoter system WO2002049669A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP01992274A EP1352073A2 (en) 2000-12-21 2001-12-20 Electrically responsive promoter system
JP2002551007A JP2004516274A (en) 2000-12-21 2001-12-20 Electrically responsive promoter system
CA002432310A CA2432310A1 (en) 2000-12-21 2001-12-20 Electrically responsive promoter system
AU2002232736A AU2002232736A1 (en) 2000-12-21 2001-12-20 Electrically responsive promoter system

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US25746000P 2000-12-21 2000-12-21
US60/257,460 2000-12-21
US31392601P 2001-08-20 2001-08-20
US60/313,926 2001-08-20

Publications (2)

Publication Number Publication Date
WO2002049669A2 WO2002049669A2 (en) 2002-06-27
WO2002049669A3 true WO2002049669A3 (en) 2003-07-24

Family

ID=26945979

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2001/048981 WO2002049714A2 (en) 2000-12-21 2001-12-18 Electrically responsive promoter system
PCT/US2001/049845 WO2002049669A2 (en) 2000-12-21 2001-12-20 Electrically responsive promoter system

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/US2001/048981 WO2002049714A2 (en) 2000-12-21 2001-12-18 Electrically responsive promoter system

Country Status (6)

Country Link
US (1) US20030204206A1 (en)
EP (1) EP1352073A2 (en)
JP (1) JP2004516274A (en)
AU (2) AU2002230999A1 (en)
CA (1) CA2432310A1 (en)
WO (2) WO2002049714A2 (en)

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Also Published As

Publication number Publication date
EP1352073A2 (en) 2003-10-15
AU2002232736A1 (en) 2002-07-01
WO2002049714A2 (en) 2002-06-27
US20030204206A1 (en) 2003-10-30
CA2432310A1 (en) 2002-06-27
JP2004516274A (en) 2004-06-03
AU2002230999A1 (en) 2002-07-01
WO2002049669A2 (en) 2002-06-27

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