WO2002051376A2

WO2002051376A2 - Nanoparticle-containing peeling compositions

Info

Publication number: WO2002051376A2
Application number: PCT/EP2001/014649
Authority: WO
Inventors: Christian Kropf; Claudia Hundeiker; Marcel Roth; Soraya Heinen; Christian Umbreit
Original assignee: Henkel Kommanditgesellschaft Auf Aktien
Priority date: 2000-12-22
Filing date: 2001-12-13
Publication date: 2002-07-04
Also published as: DE10064489A1; AU2002229654A1; WO2002051376A3

Abstract

The invention relates to aqueous compositions for the abrasive treatment of the skin of the human body, especially of the face and/or the neck. Said compositions contain, in a cosmetically and/or dermatologically acceptable excipient, a toxicologically safe nanoparticulate compound of an element of the second to fourth main group, or the second, fourth or eighth subgroup of the periodic system of elements that is poorly soluble in water. Said particles have an average particle size in the range of from 10 to 1000 nm. The inventive compositions bring about an efficient and gentle deep cleansing of the skin.

Description

Peeling compositions containing nanoparticles

The invention relates to aqueous compositions for the abrasive treatment of the skin of the human body, in particular the face and / or the neck, which, in a cosmetically and / or dermatologically compatible carrier, contain a toxicologically acceptable, water-insoluble, nanoparticulate compound of an element from the second to fourth main group or the second, fourth or eighth subgroup of the Periodic Table of the Elements, the particles having an average particle size in the range from 10 to 1000 nm. The compositions result in a thorough and gentle deep cleansing of the skin.

Aqueous surfactant solutions are usually used to clean the skin. However, stuck impurities, dead skin flakes, sebum secretions and make-up can only be removed incompletely.

It is therefore recommended to deeply clean the skin at regular intervals, using additional mechanical aids, e.g. a sponge, a cleaning cloth or an abrasive or exfoliative cleaning composition, which is also referred to as a peeling composition, is used. The use of mildly abrasive skin cleansing agents has also been proposed for the treatment of acne and other skin diseases, in order to promote the regeneration of the skin tissue and to promote the penetration of dermatological preparations applied thereafter.

While hand washing pastes with relatively coarse abrasives such as pumice powder, sea sand, sawdust or chalk are used for cleaning dirty hands, softer or finer ground abrasives are used for deep cleaning of sensitive skin, e.g. fine polymer powder, finely divided wax or triglyceride Powder and especially vegetable abrasives. Due to their emery effect, peeling compositions remove dead skin cells, massage the skin and ensure improved blood circulation. As abrasives, they usually contain oxidic materials or plastic particles, e.g. B. polyethylene particles or nylon particles, with particle sizes above 10 microns. Due to this relatively large particle size, however, only larger unevenness is removed, and burrs and flakes remain in the μm range. Superficial flakes of skin that are not removed can lead to blemishes due to the clogging of pores. Depending on the size of the particles, there is also the risk of skin injuries. Exfoliating preparations are no longer used in some countries to treat skin that tends to develop acne because it can break open microcomedomas and make inflammatory acne worse. Conventional peeling compositions can also be irritating to the skin and poorly tolerated by sensitive skin.

JP-A 11049636 proposes skin cleansing and massage compositions containing molybdenum sulfate, tungsten sulfate, selenium-coated molybdenum and selenium-coated tungsten, in which these substances are in the form of particles with a size between 50 and 2000 nm. However, on the one hand, these heavy metal compounds are not commercially available and, on the other hand, their use for cosmetic purposes is questionable for toxicological reasons, which applies in particular to the selenium-containing substances.

There was therefore a search for ways to provide abrasive skin cleansing agents which enable thorough and gentle deep cleansing of the skin and which can be produced using raw materials which are toxicologically safe, good and inexpensive.

It has been found that this object is achieved by using certain nanoparticulate compounds as mild abrasives in peeling compositions. The invention therefore relates to the use of an aqueous composition which, in a cosmetically and / or dermatologically compatible carrier, contains a toxicologically acceptable, water-insoluble nanoparticulate compound of an element of the second to fourth main group or of the second, fourth or eighth subgroup of the periodic table of the elements with a contains average particle size in the range of 10 to 1000 nm, for the abrading treatment of the skin of the human body, especially the face and / or the neck.

The invention thus relates to compositions which are particularly useful in the cosmetic and / or dermatological field for massaging, deep cleansing and / or abrading treatment of the skin of the human body, in particular the face and / or the neck. The compositions enable in particular the gentle removal of dead cells and impurities and unevenness of the skin and the opening of the skin pores.

In the sense of the invention it is understood that the composition can also contain several of the above-mentioned compounds or mixed compounds such as mixed oxides of two or more of the elements defined above. If the elements are metals, light metals (density below 5) and iron are preferred. Oxides, hydroxides, phosphates, silicates, carbonates and sulfates are preferred as compounds.

The average particle size of the nanoparticulate compounds is preferably in the range between 20 and 500 nm.

The size specifications are to be understood as diameters in the direction of the greatest longitudinal expansion of the particles; mean is the volume-weighted mean. The size of nanoparticles always follows a distribution curve. For example, the method of dynamic light scattering known to the person skilled in the art can be used for the experimental determination of the particle size. In a preferred embodiment of the invention, it is a compound of magnesium, calcium, aluminum, silicon, zinc, titanium, zirconium or iron, for example their oxides and silicates, insofar as they are sparingly soluble in water.

For the purposes of the present invention, poor solubility in water means a solubility at 20 ° C. of less than 1% by weight, preferably less than 0.1% by weight, based on the total weight of the solution.

Zinc oxide, iron oxides, zirconium dioxide, aluminum oxide and aluminum oxide hydroxide are particularly preferred as nanoparticulate compounds.

Commercially available nanoparticulate compounds suitable according to the invention are, for example, zinc oxide (Z-Cote from Sunsmart or Nanox from Rheox), magnesium silicate (Optigel SH from Süd-Chemie, Laponite XLG from Laporte), aluminum oxide (AI203 C from Fa Degussa) and aluminum oxide hydroxide (Boehmite from Condea).

In a further embodiment of the invention, the nanoparticulate compounds are enveloped by one or more surface modification agents. Surface modification is to be understood as covering the particle surface with organic compounds which interact with the surface of the particles via chemical bonds or physical forces.

Suitable surface modifiers for the nanoparticles are, for example, monobasic and polybasic carboxylic acids with 2 to 18 carbon atoms, hydroxycarboxylic acids, ether carboxylic acids, fruit acids and amino acids.

For the surface modification of the nanoparticles, functional silanes of the type (OR ') can _n SiR be used 4_ in which n is an integer between 1 and 3, ^R' is an alkyl radical having 1 to 4 carbon atoms and R is an organic hydrocarbon radical having 1 to 18 carbon atoms means where the radical R additionally contains a hydroxyl, carboxy, ester, amino, ammonium or epoxy group, quaternary ammonium compounds and amino acids are also suitable for surface modification. As further surface modification agents are, for example, gelatin, starch, dextrin, dextran, pectin, gum arabic, casein, gums, polyvinyl alcohols, polyethylene glycols, polyvinyl pyrrolidone, polyvinyl butyrals, methyl cellulose, carboxymethyl cellulose, hydroxypropyl cellulose and surfactants and emulsifiers such as, for. B. fatty alcohol polyglycol ethers, fatty alcohol polyglycosides, fatty acid alkanolamides, glycerol esters, sorbitan esters or alkoxylated esters.

For surface modification, the nanoparticles are treated, for example, with a solution of 0.05 to 0.5 mol of the surface modification agent per mol of the nanoparticulate compound, preferably in water. This treatment is preferably carried out over a period of 1-24 hours at a temperature of at least 20 ° C., but preferably at 100 ° C.

The surface-modified nanoparticles are preferably isolated from the reaction mixture by dewatering. For this purpose, the dispersion is preferably subjected to freeze drying.

Nanoparticles modified by this process preferably contain between 1 and 30% by weight, particularly preferably between 2 and 20% by weight, of the surface modification agent, based on the total weight of the surface-modified nanoparticles.

In the compositions according to the invention, the optionally surface-modified nanoparticles are contained in an amount of 0.01 to 50 and preferably 0.1 to 15% by weight, based on the total weight of the compositions.

It was found that even small skin flakes and superficial burrs and unevenness of the stratum corneum are removed by the nanoparticles used according to the invention, so that a smoother one Skin surface arises as with conventional peeling compositions. This cleanses and smoothes the skin very thoroughly and gives it an even, radiant appearance. In addition, the formation of new skin imperfections is prevented. Due to their small size, the nanoparticles do not cause an annoying granular, sandy or hard feeling when used. Another advantage is that they can be homogeneously distributed and stably dispersed in the compositions without any problems. In the case of nanoparticulate zinc oxide, the nanoparticles not only act as a mild abrasive, but they also have an antibacterial and skin-calming effect that is effective directly at the same place of action, where the abrasive effect also takes place. Nanoparticulate zinc oxide therefore has a double function as a constituent of the compositions according to the invention and thus allows the formulation of particularly abrasive skin cleansers which are gentle on the skin. It is therefore particularly preferred for the purposes of the present invention.

So that the compositions according to the invention can not only effectively remove small skin flakes and fine surface roughnesses of the skin, but also coarser particles and bumps in the order of magnitude of several μm, it is preferred if the compositions according to the invention additionally have one or more conventional ones in addition to the nanoparticulate compounds defined above Contain abrasives, which usually have an average particle size in the range of 10 to 500 microns.

Such conventional abrasives are, for example, chalk (calcite), aluminum oxide, aluminum oxide trihydrate, calcium phosphate dihydrate (CaHP0 ₄ 2H ₂ 0), calcium pyrophosphate, insoluble sodium metaphosphate and silicas (precipitation and gel silicas), as well as polyethylene or polyamide Powder. Herbal abrasives are e.g. B. the ground endocarp of apricot, peach, walnut or cherry kernels or the ground, possibly defatted pulp of almonds, coconuts, jojoba fruits, macadamia Nuts and other nuts. Vegetable flours valued as mild abrasives are e.g. B. corn on the cob, wheat bran, oatmeal and wood flour.

The conventional abrasives defined above can be contained in the compositions according to the invention in an amount of 0.1 to 30% by weight, based on the total weight of the composition.

Other optional components in the compositions for abrasive skin cleaning according to the invention are auxiliaries such as. B. thickeners, surfactants, fatty substances,

Preservatives, pH adjusting agents or buffer salts, dyes, fragrances, glycols and polyols such as e.g. Glycerin, sorbitol or propylene glycol and optionally cosmetic or dermatological active ingredients, e.g. antimicrobial, sebosuppressive, anti-inflammatory (anti-inflammatory) agents, plant extracts, vitamins, proteins and protein derivatives.

As a thickener z. B. guar, cellulose derivatives, vegetable gums and microbial polysaccharides such as xanthan gum, inorganic substances such as. B. layered silicates, e.g. B. bentonite, montmorillonite, kaolin, talc and organically modified phyllosilicates, aluminosilicates and pyrogenic silicas. As synthetic organic thickeners can additionally z. B. water-soluble polyethylene oxides, polyurethanes, polyvinyl pyrrolidone,

Polyvinyl alcohol and polyacrylamides are used.

Anionic, zwitterionic, ampholytic and nonionic surfactants and mixtures thereof are suitable as surface-active substances. The surfactants are preferably present in the compositions in amounts of 0.1-30% by weight. Suitable surfactants are characterized by a preferably linear alkyl group or acyl group with 8-22 C atoms and a polar, ionic or nonionic grouping. Examples of particularly suitable surface-active substances are, above all, the readily water-soluble anionic surfactants, such as those which produce foam in an aqueous medium. B. the alkyl sulfates and alkyl ether sulfates, the alkyl (polyglycol ether) carboxylates, the Alkyl sulfosuccinate salts, alkane sulfonates, α-olefin sulfonates,

Acyl sarcosinates, acyl taurides and acyl isethionates.

The preparations according to the invention can be in the form of a lotion, a paste, a cream, a gel or another conventional form of application.

Flowable lotions with viscosities of 1-500 Pa s (20 ° C) or pastes with viscosities of more than 500 Pa s (20 ° C) are preferred. They can also contain emulsified oil or fat components or dispersed waxes or other meltable fat components to thicken and improve the skin cosmetic properties. Preferred waxes are hydrogenated castor oil, particularly preferably in the form of nanoparticulate particles, optionally coated with a surfactant or emulsifier, as described, for example, in patent application DE 10059668.1.

The invention further relates to a method for cleaning and / or for the abrading treatment of the skin of the human body, in particular the face and / or the neck, which consists in applying a composition as defined above to the skin, the skin for removal of blemishes and imperfections is massaged with this composition, and then the skin is rinsed off, which is preferably done with water.

The following examples are intended to explain the subject matter of the invention in more detail without restricting it thereto: Examples:

Examples 1-3: Formulations for skin peeling compositions

For the use of nanoparticulate zinc oxide in the following formulations, a zinc oxide paste was first produced by adding 81 g of nanoparticulate zinc oxide (Z-Cote from Sunsmart, average primary particle size smaller than 200 nm) and 19 g of Plantacare 1200 UP (C12-C16-alkyl polyglycoside) , 50% by weight of active substance in water) were intimately mixed in a laboratory kneader. The average particle size in the paste was 280 nm. To measure the particle size, a 1% by weight aqueous dispersion was prepared from the paste by stirring it into water. The measurement was carried out using the UPA 3.150 device from Microtrac.

To produce the peeling compositions, the constituents of phase 1 were first heated to 80 ° C. with stirring, held at 80 ° C. for about 2 minutes, and then cooled to about 35 ° C. with stirring. ZnO paste and phase 2 water were then mixed and added to phase 1 with stirring. The avocadol, heated to 40 ° C., was then added, and the remaining components of phase 2 were then added in succession. The mixture was stirred until a homogeneous preparation had formed. Example 4: Peeling cream

Example 5: Peeling gel

The gel was adjusted to pH 5.5 with citric acid.

Claims

claims

1. Use of an aqueous composition which, in a cosmetically and / or dermatologically compatible carrier, contains a toxicologically acceptable, poorly water-soluble, nanoparticulate compound of an element of the second to fourth main group or the second, fourth or eighth subgroup of the periodic table of the elements with an average particle size in the range contains from 10 to 1000 nm, for the abrading treatment of the skin of the human body, especially the face and / or the neck.

2. Use according to claim 1, characterized in that the average particle size is in the range between 20 and 500 nm.

3. Use according to one of claims 1 or 2, characterized in that the element is selected from the group formed by magnesium, calcium, aluminum, silicon, zinc, titanium, zirconium and iron.

4. Use according to one of claims 1 to 3, characterized in that the compound is selected from the group formed by zinc oxide, aluminum oxide, aluminum oxide hydroxide, iron oxides and zirconium dioxide.

5. Use according to one of claims 1 to 4, characterized in that the nanoparticles are coated by a surface modification agent.

6. Use according to one of claims 1 to 5, characterized in that the proportion of the optionally surface-modified nanoparticles is 0.01 to 50 and preferably 0.1 to 15 wt .-% of the composition.

7. Use according to one of claims 1 to 6, characterized in that the composition 0.1 to 30 wt .-% of an abrasive with a contains average particle size in the range of 10 to 500 microns, based on the total weight of the composition.

8. Use according to one of claims 1 to 7, characterized in that the composition further contains at least one auxiliary substance which is selected from the group consisting of thickeners, surface-active substances, fatty substances, preservatives and fragrances.

9. Use according to one of claims 1 to 8, characterized in that the composition is a lotion, paste, cream or a gel.

10. Aqueous composition for the abrasive treatment of the skin of the human body, in particular the face and / or the neck, containing a cosmetically and / or dermatologically compatible carrier, an abrasive with an average particle size in the range from 10 to 500 μm and a toxicologically acceptable sparingly water-soluble nanoparticulate compound of an element of the second to fourth main group or the second, fourth or eighth subgroup of the periodic table of the elements with an average particle size in the range from 10 to 1000 nm.

11.Composition according to claim 10, characterized in that the element is selected from the group formed by magnesium, calcium, aluminum, silicon, zinc, titanium, zirconium and iron.

^ .Composition according to one of claims 10 or 11, characterized in that the nanoparticulate compound is selected from the group formed by zinc oxide, aluminum oxide, aluminum oxide hydroxide, iron oxides and zirconium dioxide.

13. Composition according to one of claims 10 to 12, characterized in that the nanoparticulate compound in an amount of 0.01 to 50 and preferably from 0.1 to 15 wt .-%, based on the total weight of the composition.

^ .Composition according to one of claims 10 to 13, characterized in that an abrasive is contained in an amount of 0.1 to 30 wt .-%, based on the total weight of the composition.

15. Composition according to one of claims 10 to 14, characterized in that it is in the form of a lotion, paste, cream or a gel.