WO2002052260A3 - Biosensor and method of producing the same - Google Patents

Biosensor and method of producing the same Download PDF

Info

Publication number
WO2002052260A3
WO2002052260A3 PCT/EP2001/015225 EP0115225W WO02052260A3 WO 2002052260 A3 WO2002052260 A3 WO 2002052260A3 EP 0115225 W EP0115225 W EP 0115225W WO 02052260 A3 WO02052260 A3 WO 02052260A3
Authority
WO
WIPO (PCT)
Prior art keywords
layer
biosensor
plasmon
protective layer
carrying
Prior art date
Application number
PCT/EP2001/015225
Other languages
German (de)
French (fr)
Other versions
WO2002052260A2 (en
WO2002052260A9 (en
Inventor
Andreas Hofmann
Original Assignee
Andreas Hofmann
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Andreas Hofmann filed Critical Andreas Hofmann
Priority to AU2002237253A priority Critical patent/AU2002237253A1/en
Publication of WO2002052260A2 publication Critical patent/WO2002052260A2/en
Publication of WO2002052260A9 publication Critical patent/WO2002052260A9/en
Publication of WO2002052260A3 publication Critical patent/WO2002052260A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings

Abstract

The invention relates to a biosensor comprising a support (1) (prism of glass), a plasmon-carrying layer (2) that consists of a metal layer with free electrons, especially gold or silver, or a semiconductor layer and a hydrogel layer (6) that consists of a polymer, especially a dextran to which receptors (7) can be bound. Said biosensor is further provided with a protective layer (4) that consists of a silicon oxide or a metal oxide, or a protective layer (9) that consists of a polymer and that is physisorbed to the plasmon-carrying layer (2). The hydrogel layer (6) can be bound via a linker (5, 10), for example in the case of a protective layer (4) from silicon oxide by for example silane as the linker (5). The protective layer (4) has a thickness of less than 10 nm, preferably less than 5 nm, and effectively protects the active plasmon-carrying layer (2) from any disturbing contaminations. The physical optical effect produced by the surface plasmon resonance does not take place outside the range that can be measured so that the suitability as a biosensor is not lost.
PCT/EP2001/015225 2000-12-22 2001-12-21 Biosensor and method of producing the same WO2002052260A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002237253A AU2002237253A1 (en) 2000-12-22 2001-12-21 Biosensor and method of producing the same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2000164146 DE10064146A1 (en) 2000-12-22 2000-12-22 Biosensor and method for its production
DE10064146.6 2000-12-22

Publications (3)

Publication Number Publication Date
WO2002052260A2 WO2002052260A2 (en) 2002-07-04
WO2002052260A9 WO2002052260A9 (en) 2002-09-19
WO2002052260A3 true WO2002052260A3 (en) 2002-11-14

Family

ID=7668367

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/015225 WO2002052260A2 (en) 2000-12-22 2001-12-21 Biosensor and method of producing the same

Country Status (3)

Country Link
AU (1) AU2002237253A1 (en)
DE (1) DE10064146A1 (en)
WO (1) WO2002052260A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004061211A (en) * 2002-07-26 2004-02-26 Shimadzu Corp Method and device for detecting fluorescence
JP2006322939A (en) * 2005-05-19 2006-11-30 Agilent Technol Inc Evanescent wave sensor having combined ligand
US7889347B2 (en) 2005-11-21 2011-02-15 Plexera Llc Surface plasmon resonance spectrometer with an actuator driven angle scanning mechanism
US7463358B2 (en) * 2005-12-06 2008-12-09 Lumera Corporation Highly stable surface plasmon resonance plates, microarrays, and methods
US20080188010A1 (en) * 2007-02-01 2008-08-07 Fujifilm Corporation Biosensor substrate
JP5021408B2 (en) * 2007-09-26 2012-09-05 富士フイルム株式会社 Biosensor
US8004669B1 (en) 2007-12-18 2011-08-23 Plexera Llc SPR apparatus with a high performance fluid delivery system
FR2946433B1 (en) 2009-06-05 2013-07-12 Ecole Polytechnique Dgar USE OF AN AMORPHOUS SILICON LAYER AND ANALYSIS METHOD

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988007202A1 (en) * 1987-03-10 1988-09-22 Ares-Serono Research & Development Limited Partner Improved assay technique and apparatus therefor
US4992385A (en) * 1986-07-24 1991-02-12 Ares-Serono Research And Development Limited Partnership Polymer-coated optical structures and methods of making and using the same
DE19805809A1 (en) * 1998-02-12 1999-09-02 Biotul Bio Instr Gmbh Transducer for determining surface plasmon resonances using spatially or time-modified layers for surface plasmon resonance spectroscopy
EP0945721A2 (en) * 1998-03-24 1999-09-29 Dai Nippon Printing Co., Ltd. Biosensitive element for surface plasmon resonance measurements, and its method of manufacture
DE19817180A1 (en) * 1998-04-17 1999-10-21 Biotul Bio Instr Gmbh Biosensor, especially for surface plasmon resonance, with surface comprising noble metal film bound to hydrogel via monolayer of organic molecules
DE19853428A1 (en) * 1998-11-19 2000-05-25 Biotul Bio Instr Gmbh Biosensor, used in surface plasmon resonance techniques, comprises surface layer of precious metal bound to a hydrogel, a surfactant or biotin layer via monolayer of organic molecules

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19818360C2 (en) * 1998-04-24 2000-05-31 Suisse Electronique Microtech Dextran coated surface

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4992385A (en) * 1986-07-24 1991-02-12 Ares-Serono Research And Development Limited Partnership Polymer-coated optical structures and methods of making and using the same
WO1988007202A1 (en) * 1987-03-10 1988-09-22 Ares-Serono Research & Development Limited Partner Improved assay technique and apparatus therefor
DE19805809A1 (en) * 1998-02-12 1999-09-02 Biotul Bio Instr Gmbh Transducer for determining surface plasmon resonances using spatially or time-modified layers for surface plasmon resonance spectroscopy
EP0945721A2 (en) * 1998-03-24 1999-09-29 Dai Nippon Printing Co., Ltd. Biosensitive element for surface plasmon resonance measurements, and its method of manufacture
DE19817180A1 (en) * 1998-04-17 1999-10-21 Biotul Bio Instr Gmbh Biosensor, especially for surface plasmon resonance, with surface comprising noble metal film bound to hydrogel via monolayer of organic molecules
DE19853428A1 (en) * 1998-11-19 2000-05-25 Biotul Bio Instr Gmbh Biosensor, used in surface plasmon resonance techniques, comprises surface layer of precious metal bound to a hydrogel, a surfactant or biotin layer via monolayer of organic molecules

Also Published As

Publication number Publication date
WO2002052260A2 (en) 2002-07-04
DE10064146A1 (en) 2002-07-04
WO2002052260A9 (en) 2002-09-19
AU2002237253A1 (en) 2002-07-08

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