WO2002059402A3 - Apparatus and method for the automated preparation of biopolymer crystals with high output - Google Patents

Apparatus and method for the automated preparation of biopolymer crystals with high output Download PDF

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Publication number
WO2002059402A3
WO2002059402A3 PCT/US2001/048151 US0148151W WO02059402A3 WO 2002059402 A3 WO2002059402 A3 WO 2002059402A3 US 0148151 W US0148151 W US 0148151W WO 02059402 A3 WO02059402 A3 WO 02059402A3
Authority
WO
WIPO (PCT)
Prior art keywords
high output
station
microplate
automated preparation
biopolymer crystals
Prior art date
Application number
PCT/US2001/048151
Other languages
French (fr)
Other versions
WO2002059402A2 (en
Inventor
Abraham Shtrahman
Matthew Shtrahman
Gregory Shtrahman
Original Assignee
Abraham Shtrahman
Matthew Shtrahman
Gregory Shtrahman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abraham Shtrahman, Matthew Shtrahman, Gregory Shtrahman filed Critical Abraham Shtrahman
Priority to AU2002246647A priority Critical patent/AU2002246647A1/en
Publication of WO2002059402A2 publication Critical patent/WO2002059402A2/en
Publication of WO2002059402A3 publication Critical patent/WO2002059402A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B29/00—Single crystals or homogeneous polycrystalline material with defined structure characterised by the material or by their shape
    • C30B29/54—Organic compounds
    • C30B29/58—Macromolecular compounds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S117/00—Single-crystal, oriented-crystal, and epitaxy growth processes; non-coating apparatus therefor
    • Y10S117/90—Apparatus characterized by composition or treatment thereof, e.g. surface finish, surface coating
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T117/00—Single-crystal, oriented-crystal, and epitaxy growth processes; non-coating apparatus therefor
    • Y10T117/10—Apparatus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T117/00—Single-crystal, oriented-crystal, and epitaxy growth processes; non-coating apparatus therefor
    • Y10T117/10—Apparatus
    • Y10T117/1004—Apparatus with means for measuring, testing, or sensing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T117/00—Single-crystal, oriented-crystal, and epitaxy growth processes; non-coating apparatus therefor
    • Y10T117/10—Apparatus
    • Y10T117/1004—Apparatus with means for measuring, testing, or sensing
    • Y10T117/1008—Apparatus with means for measuring, testing, or sensing with responsive control means

Abstract

A fully automated, high output robotic station for the crystallization of proteins and other biopolymers via the sitting drop vapor diffusion and micro-batch methods. This station performs microplate feeding, liquid aspiration, dilution, and dispensing, as well as microplate sealing and storage into a temperature controlled hotel. All functions are microprocessor controlled. The operator designs the process via graphical user interface, after which the station executes the process automatically to completion.
PCT/US2001/048151 2000-10-30 2001-10-30 Apparatus and method for the automated preparation of biopolymer crystals with high output WO2002059402A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002246647A AU2002246647A1 (en) 2000-10-30 2001-10-30 Apparatus and method for the automated preparation of biopolymer crystals with high output

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/699,623 US6402837B1 (en) 2000-10-30 2000-10-30 Apparatus and method of preparation for automated high output biopolymer crystallization via vapor diffusion sitting drop and micro-batch techniques
US09/699,623 2000-10-30

Publications (2)

Publication Number Publication Date
WO2002059402A2 WO2002059402A2 (en) 2002-08-01
WO2002059402A3 true WO2002059402A3 (en) 2002-10-10

Family

ID=24810152

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/048151 WO2002059402A2 (en) 2000-10-30 2001-10-30 Apparatus and method for the automated preparation of biopolymer crystals with high output

Country Status (3)

Country Link
US (1) US6402837B1 (en)
AU (1) AU2002246647A1 (en)
WO (1) WO2002059402A2 (en)

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US6838051B2 (en) * 1999-05-03 2005-01-04 Ljl Biosystems, Inc. Integrated sample-processing system
ATE357656T1 (en) * 1999-04-06 2007-04-15 Univ Alabama Res Found DEVICE FOR SCREENING CRYSTALIZATION CONDITIONS IN CRYSTAL GROWING SOLUTIONS
US7214540B2 (en) * 1999-04-06 2007-05-08 Uab Research Foundation Method for screening crystallization conditions in solution crystal growth
US20030022383A1 (en) * 1999-04-06 2003-01-30 Uab Research Foundation Method for screening crystallization conditions in solution crystal growth
US7247490B2 (en) * 1999-04-06 2007-07-24 Uab Research Foundation Method for screening crystallization conditions in solution crystal growth
US7250305B2 (en) * 2001-07-30 2007-07-31 Uab Research Foundation Use of dye to distinguish salt and protein crystals under microcrystallization conditions
US7244396B2 (en) * 1999-04-06 2007-07-17 Uab Research Foundation Method for preparation of microarrays for screening of crystal growth conditions
US6630006B2 (en) * 1999-06-18 2003-10-07 The Regents Of The University Of California Method for screening microcrystallizations for crystal formation
US6818060B2 (en) * 1999-08-02 2004-11-16 Emerald Biostructures, Inc. Robot for mixing crystallization trial matrices
US20020169512A1 (en) * 1999-08-02 2002-11-14 Decode Genetics Ehf. Plate mover for crystallization data collection
US6979425B1 (en) * 1999-10-04 2005-12-27 Robodesign International, Inc. High capacity microarray dispensing
US7670429B2 (en) * 2001-04-05 2010-03-02 The California Institute Of Technology High throughput screening of crystallization of materials
US7158888B2 (en) 2001-05-04 2007-01-02 Takeda San Diego, Inc. Determining structures by performing comparisons between molecular replacement results for multiple different biomolecules
US20030087455A1 (en) * 2001-11-07 2003-05-08 Eggers Mitchell D Sample carrier system
US7584240B2 (en) 2001-11-07 2009-09-01 Genvault Corporation Automated biological sample archive for storage, retrieval and analysis of large numbers of samples for remote clients
US20030129755A1 (en) * 2001-11-07 2003-07-10 Genvault Corporation System and method of storing and retrieving storage elements
US20030087425A1 (en) * 2001-11-07 2003-05-08 Eggers Mitchell D Sample carrier
US20070026528A1 (en) * 2002-05-30 2007-02-01 Delucas Lawrence J Method for screening crystallization conditions in solution crystal growth
US20040007672A1 (en) * 2002-07-10 2004-01-15 Delucas Lawrence J. Method for distinguishing between biomolecule and non-biomolecule crystals
US7718442B2 (en) * 2002-11-22 2010-05-18 Genvault Corporation Sealed sample storage element system and method
US6889727B2 (en) * 2003-02-21 2005-05-10 Abbott Laboratories Apparatus and method for the preparation of experiments using proteins contained within gels
US20100075858A1 (en) * 2003-04-29 2010-03-25 Genvault Corporation Biological bar code
US7416710B1 (en) 2003-12-31 2008-08-26 Takeda San Diego, Inc. Method and system for performing crystallization trials
EP1758937B1 (en) * 2004-05-24 2009-09-02 Genvault Corporation Stable protein storage and stable nucleic acid storage in recoverable form
US20060006774A1 (en) * 2004-07-09 2006-01-12 Kendro Laboratory Products, Lp Microplate storage apparatus and method
US20060018996A1 (en) * 2004-07-09 2006-01-26 Pollock Paul W Automatic discovery of a storage configuration method and apparatus
KR100602972B1 (en) 2005-02-15 2006-07-20 한국과학기술연구원 Protein crystal inspection system
US20100209957A1 (en) * 2008-06-20 2010-08-19 Genvault Corporation Biosample storage devices and methods of use thereof
WO2010031007A2 (en) 2008-09-12 2010-03-18 Genvault Corporation Matrices and media for storage and stabilization of biomolecules
NL2005952C2 (en) * 2011-01-05 2012-07-10 Lab Services B V SYSTEM FOR STORING AND EDITING TITER PLATES.
CN105859830B (en) * 2016-03-22 2019-08-06 苏州捷美电子有限公司 A kind of LCP experimental provision and experimental method

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EP0225050A2 (en) * 1985-10-30 1987-06-10 Fujitsu Limited Automated biopolymer crystal preparation apparatus and process
US5013531A (en) * 1990-08-31 1991-05-07 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Macromolecular crystal growing system
US5096676A (en) * 1989-01-27 1992-03-17 Mcpherson Alexander Crystal growing apparatus
GB2249492A (en) * 1989-12-13 1992-05-13 Imperial College Crystallisation method and apparatus
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US5096676A (en) * 1989-01-27 1992-03-17 Mcpherson Alexander Crystal growing apparatus
GB2249492A (en) * 1989-12-13 1992-05-13 Imperial College Crystallisation method and apparatus
US5013531A (en) * 1990-08-31 1991-05-07 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Macromolecular crystal growing system
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DE19843655A1 (en) * 1998-09-23 2000-03-30 Bayer Ag Hanging drop process and assembly for the crystallisation of biological macro-molecules minimizes the incidence of false results
US6296673B1 (en) * 1999-06-18 2001-10-02 The Regents Of The University Of California Methods and apparatus for performing array microcrystallizations

Non-Patent Citations (1)

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Title
CHAYEN N E ET AL: "MICROBATCH CRYSTALLIZATION UNDER OIL - A NEW TECHNIQUE ALLOWING MANY SMALL-VOLUME CRYSTALLIZATION TRIALS", JOURNAL OF CRYSTAL GROWTH, NORTH-HOLLAND PUBLISHING CO. AMSTERDAM, NL, vol. 122, no. 1 / 4, 2 August 1992 (1992-08-02), pages 176 - 180, XP000306492, ISSN: 0022-0248 *

Also Published As

Publication number Publication date
AU2002246647A1 (en) 2002-08-06
US6402837B1 (en) 2002-06-11
WO2002059402A2 (en) 2002-08-01

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