WO2002059562A3 - Analysis of gene expression and biological function using optical imaging - Google Patents

Analysis of gene expression and biological function using optical imaging Download PDF

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Publication number
WO2002059562A3
WO2002059562A3 PCT/US2002/002414 US0202414W WO02059562A3 WO 2002059562 A3 WO2002059562 A3 WO 2002059562A3 US 0202414 W US0202414 W US 0202414W WO 02059562 A3 WO02059562 A3 WO 02059562A3
Authority
WO
WIPO (PCT)
Prior art keywords
gene expression
analysis
vivo
biological function
methods
Prior art date
Application number
PCT/US2002/002414
Other languages
French (fr)
Other versions
WO2002059562A2 (en
Inventor
June Iris Medford
Ronald Lee Parsons
Aaron Reeves
Original Assignee
Univ Colorado State Res Found
June Iris Medford
Ronald Lee Parsons
Aaron Reeves
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Colorado State Res Found, June Iris Medford, Ronald Lee Parsons, Aaron Reeves filed Critical Univ Colorado State Res Found
Priority to EP02720859A priority Critical patent/EP1366349A4/en
Priority to US10/470,211 priority patent/US20040115683A1/en
Priority to AU2002251830A priority patent/AU2002251830A1/en
Publication of WO2002059562A2 publication Critical patent/WO2002059562A2/en
Publication of WO2002059562A3 publication Critical patent/WO2002059562A3/en

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Classifications

    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/60—Analysis of geometric attributes

Abstract

The present invention provides methods, composition, software and apparatus for in vivo analysis of gene expression and biological function in plants and animals. The invention also provides materials and methods fo rapid analysis of data, allowing the methods and compositions of the invention to be used in a high throughput manner. The materials include an optical coherence microscope, the use and identification of detectable OCM substances, and machine readable code that converts OCM signal to binary data and then to a visual image, by which the expression of genes in vivo can be visualized. The present method results in the creation of genomic-scale, computer screenable databases of gene expression that include spatial, temporal, and quantitative data about gene expression in vivo.
PCT/US2002/002414 2001-01-26 2002-01-28 Analysis of gene expression and biological function using optical imaging WO2002059562A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP02720859A EP1366349A4 (en) 2001-01-26 2002-01-28 Analysis of gene expression and biological function using optical imaging
US10/470,211 US20040115683A1 (en) 2002-01-28 2002-01-28 Analysis of gene expression and biological function using optical imaging
AU2002251830A AU2002251830A1 (en) 2001-01-26 2002-01-28 Analysis of gene expression and biological function using optical imaging

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US26445001P 2001-01-26 2001-01-26
US26464101P 2001-01-26 2001-01-26
US60/264,450 2001-01-26
US60/264,641 2001-01-26

Publications (2)

Publication Number Publication Date
WO2002059562A2 WO2002059562A2 (en) 2002-08-01
WO2002059562A3 true WO2002059562A3 (en) 2002-10-31

Family

ID=26950552

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/002414 WO2002059562A2 (en) 2001-01-26 2002-01-28 Analysis of gene expression and biological function using optical imaging

Country Status (3)

Country Link
EP (1) EP1366349A4 (en)
AU (1) AU2002251830A1 (en)
WO (1) WO2002059562A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070186313A1 (en) * 2006-01-31 2007-08-09 Pioneer Hi-Bred International, Inc. Method for high throughput transgene function analysis for agronomic traits in maize
CN103236052B (en) * 2013-03-28 2014-05-07 华中科技大学 Automatic cell localization method based on minimized model L1
CN112730352A (en) * 2020-12-08 2021-04-30 北京林业大学 Method for observing structure, area and spatial distribution of plant cell nucleus protein in real time

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4716414A (en) * 1984-05-10 1987-12-29 The Secretary Of State For Defence In Her Britannic Majesty's Government Of The United Kingdom Of Great Britain And Northern Ireland Super resolution imaging system
US5488504A (en) * 1993-08-20 1996-01-30 Martin Marietta Corp. Hybridized asymmetric fabry-perot quantum well light modulator
US5579161A (en) * 1992-11-12 1996-11-26 Olympus Optical Co., Ltd. Image display apparatus
US5936731A (en) * 1991-02-22 1999-08-10 Applied Spectral Imaging Ltd. Method for simultaneous detection of multiple fluorophores for in situ hybridization and chromosome painting
US6159681A (en) * 1997-05-28 2000-12-12 Syntrix Biochip, Inc. Light-mediated method and apparatus for the regional analysis of biologic material

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9206297A (en) * 1991-07-19 1995-10-17 Univ Michigan State Transgenic plants producing polyhydroxyalkanoates
US5650135A (en) * 1994-07-01 1997-07-22 The Board Of Trustees Of The Leland Stanford Junior University Non-invasive localization of a light-emitting conjugate in a mammal
EP0979298B1 (en) * 1997-04-28 2008-06-11 Anticancer, Inc. Metastasis models using green fluorescent protein (gfp) as a marker
US6166301A (en) * 1998-06-30 2000-12-26 The Regents Of The Unversity Of California Method for assaying genetic attributes in cotton fiber cells
EP1147398B1 (en) * 1999-01-29 2004-06-09 June Iris Medford Optical coherence microscope and method for rapid 3d-in-vivo visualization of biological functions

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4716414A (en) * 1984-05-10 1987-12-29 The Secretary Of State For Defence In Her Britannic Majesty's Government Of The United Kingdom Of Great Britain And Northern Ireland Super resolution imaging system
US5936731A (en) * 1991-02-22 1999-08-10 Applied Spectral Imaging Ltd. Method for simultaneous detection of multiple fluorophores for in situ hybridization and chromosome painting
US5579161A (en) * 1992-11-12 1996-11-26 Olympus Optical Co., Ltd. Image display apparatus
US5488504A (en) * 1993-08-20 1996-01-30 Martin Marietta Corp. Hybridized asymmetric fabry-perot quantum well light modulator
US6159681A (en) * 1997-05-28 2000-12-12 Syntrix Biochip, Inc. Light-mediated method and apparatus for the regional analysis of biologic material

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CALLEJA ET AL.: "Visualization of gene expression in living adult drosophila", SCIENCE, vol. 274, 11 October 1996 (1996-10-11), pages 252 - 255, XP002954601 *
KRISTENSEN ET AL.: "State-dependent cellular activity patterns of the cat paraventricular hypothalamus measured by reflectance imaging", BRAIN RESEARCH, vol. 727, 1996, pages 107 - 117, XP002954602 *
PAN ET AL.: "Low-coherence optical tomography in turbid tissues: theoretical analysis", APPLIED OPTICS, vol. 34, no. 28, 1 October 1995 (1995-10-01), pages 6564 - 6574, XP000528366 *
See also references of EP1366349A4 *

Also Published As

Publication number Publication date
AU2002251830A1 (en) 2002-08-06
WO2002059562A2 (en) 2002-08-01
EP1366349A2 (en) 2003-12-03
EP1366349A4 (en) 2005-02-09

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