WO2002061092A3 - Regulation of human lysyl oxidase - Google Patents

Regulation of human lysyl oxidase Download PDF

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Publication number
WO2002061092A3
WO2002061092A3 PCT/EP2002/000807 EP0200807W WO02061092A3 WO 2002061092 A3 WO2002061092 A3 WO 2002061092A3 EP 0200807 W EP0200807 W EP 0200807W WO 02061092 A3 WO02061092 A3 WO 02061092A3
Authority
WO
WIPO (PCT)
Prior art keywords
lysyl oxidase
human lysyl
regulation
reagents
diseases
Prior art date
Application number
PCT/EP2002/000807
Other languages
French (fr)
Other versions
WO2002061092A2 (en
Inventor
Yonghong Xiao
Original Assignee
Bayer Ag
Yonghong Xiao
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Yonghong Xiao filed Critical Bayer Ag
Publication of WO2002061092A2 publication Critical patent/WO2002061092A2/en
Publication of WO2002061092A3 publication Critical patent/WO2002061092A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
    • C12N9/0022—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with oxygen as acceptor (1.4.3)

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Reagents that regulate human lysyl oxidase and reagents which bind to human lysyl oxidase gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, COPD, cancer cardiovascular disease, genitourinary diseases, and metabolic diseases.
PCT/EP2002/000807 2001-01-29 2002-01-25 Regulation of human lysyl oxidase WO2002061092A2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US26431301P 2001-01-29 2001-01-29
US60/264,313 2001-01-29
US30760901P 2001-07-26 2001-07-26
US60/307,609 2001-07-26
US33095401P 2001-11-05 2001-11-05
US60/330,954 2001-11-05

Publications (2)

Publication Number Publication Date
WO2002061092A2 WO2002061092A2 (en) 2002-08-08
WO2002061092A3 true WO2002061092A3 (en) 2003-08-28

Family

ID=27401691

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/000807 WO2002061092A2 (en) 2001-01-29 2002-01-25 Regulation of human lysyl oxidase

Country Status (1)

Country Link
WO (1) WO2002061092A2 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8163494B2 (en) 2002-11-27 2012-04-24 Technion Research & Development Foundation Ltd. Method for assessing metastatic properties of breast cancer
US8461303B2 (en) 2007-08-02 2013-06-11 Gilead Biologics, Inc. LOX and LOXL2 inhibitors and uses thereof
US8927700B2 (en) 2009-08-21 2015-01-06 Gilead Biologics, Inc. Catalytic domains from lysyl oxidase and LOXL2
US9107935B2 (en) 2009-01-06 2015-08-18 Gilead Biologics, Inc. Chemotherapeutic methods and compositions

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2855968B1 (en) * 2003-06-13 2012-11-30 Coletica STIMULATION OF THE SYNTHESIS AND ACTIVITY OF A LYSYL OXIDASE-LIKE LOXL ISOFORM TO STIMULATE THE FORMATION OF ELASTIC FIBERS
FR2855969B1 (en) * 2003-06-13 2012-11-30 Coletica STIMULATION OF THE ACTIVITY OF A LYSYL OXIDASE ISOFORM TO FIGHT CERTAIN PATHOLOGIES DUE TO AN INCOMPLETE, ABSENT OR DISORGANIZED ELASTOGENESIS
US7255856B2 (en) 2004-01-23 2007-08-14 Massachusetts Eye & Ear Infirmary Lysyl oxidase-like 1 (LOXL1) and elastogenesis
JP4954450B2 (en) * 2004-06-14 2012-06-13 ビーエーエスエフ ビューティ ケア ソリューションズ フランス エスエーエス Induction of lysyl oxidase isoform activity to address disease states due to failure, loss or disorder of elastic fiber formation
JP6353082B2 (en) * 2014-06-11 2018-07-04 ギリアード サイエンシーズ， インコーポレイテッド Methods for treating cardiovascular disease
CN113321743B (en) * 2021-07-02 2022-10-21 海南精准医疗科技有限公司 Chimeric antigen receptor of targeting lysyl oxidase 1 and application thereof

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] EBI; 17 March 1997 (1997-03-17), SAITO H. ET AL.: "Human lysyl oxidase-related protein (WS9-14) mRNA, complete cds.", XP002227338, Database accession no. U89942 *
DATABASE EMBL [online] EBI; 25 August 2000 (2000-08-25), STRAUSBERG R.: "601462492F1 NIH_MGC_67 Homo sapiens cDNA clone IMAGE:3865799 5', mRNA sequence.", XP002227337, Database accession no. BE618237 *
DATABASE EMBL [online] EBI; 29 September 2000 (2000-09-29), SUGANO S. ET AL.: "Homo sapiens cDNA: FLJ21889 fis, clone HEP03178.", XP002227336, Database accession no. AK025542 *
DATABASE EMBL [online] EBI; 7 January 2002 (2002-01-07), MEYERS R.: "Sequence 2 from patent WO0192495", XP002227339, Database accession no. AX323480 *
DATABASE SWISSPROT [online] 1 May 1999 (1999-05-01), LANGENAU D.M. ET AL: "Lysyl oxidase-like protein (Fragment).", XP002227334, Database accession no. Q9YHC1 *
DATABASE SWISSPROT [online] 1 November 1999 (1999-11-01), LANGENAU D.M. ET AL: "Lysyl oxidase related protein homolog.", XP002227335, Database accession no. Q9W6N1 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8163494B2 (en) 2002-11-27 2012-04-24 Technion Research & Development Foundation Ltd. Method for assessing metastatic properties of breast cancer
US8461303B2 (en) 2007-08-02 2013-06-11 Gilead Biologics, Inc. LOX and LOXL2 inhibitors and uses thereof
US8679485B2 (en) 2007-08-02 2014-03-25 Gilead Biologics, Inc. Methods and compositions for treatment and diagnosis of fibrosis, tumor invasion, angiogenesis, and metastasis
US9176139B2 (en) 2007-08-02 2015-11-03 Gilead Biologics, Inc. LOX and LOXL2 inhibitors and uses thereof
US9107935B2 (en) 2009-01-06 2015-08-18 Gilead Biologics, Inc. Chemotherapeutic methods and compositions
US9289447B2 (en) 2009-01-06 2016-03-22 Gilead Biologics, Inc. Chemotherapeutic methods and compositions
US8927700B2 (en) 2009-08-21 2015-01-06 Gilead Biologics, Inc. Catalytic domains from lysyl oxidase and LOXL2

Also Published As

Publication number Publication date
WO2002061092A2 (en) 2002-08-08

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