WO2002062368A8 - Method of inducing a ctl response - Google Patents
Method of inducing a ctl responseInfo
- Publication number
- WO2002062368A8 WO2002062368A8 PCT/US2002/002033 US0202033W WO02062368A8 WO 2002062368 A8 WO2002062368 A8 WO 2002062368A8 US 0202033 W US0202033 W US 0202033W WO 02062368 A8 WO02062368 A8 WO 02062368A8
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- antigen
- ctl response
- inducing
- mammal
- disclosed
- Prior art date
Links
- 230000001939 inductive effect Effects 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000000427 antigen Substances 0.000 abstract 6
- 102000036639 antigens Human genes 0.000 abstract 6
- 108091007433 antigens Proteins 0.000 abstract 6
- 241000124008 Mammalia Species 0.000 abstract 3
- 230000001900 immune effect Effects 0.000 abstract 3
- 210000004324 lymphatic system Anatomy 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000002459 sustained effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55522—Cytokines; Lymphokines; Interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/10011—Arenaviridae
- C12N2760/10022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/10011—Arenaviridae
- C12N2760/10034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2002247023A AU2002247023A1 (en) | 2001-02-02 | 2002-01-22 | Method of inducing a ctl response |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/776,232 | 2001-02-02 | ||
US09/776,232 US6977074B2 (en) | 1997-07-10 | 2001-02-02 | Method of inducing a CTL response |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2002062368A2 WO2002062368A2 (en) | 2002-08-15 |
WO2002062368A3 WO2002062368A3 (en) | 2003-09-25 |
WO2002062368A8 true WO2002062368A8 (en) | 2003-11-20 |
Family
ID=25106827
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2002/002033 WO2002062368A2 (en) | 2001-02-02 | 2002-01-22 | Method of inducing a ctl response |
Country Status (3)
Country | Link |
---|---|
US (4) | US6977074B2 (en) |
AU (2) | AU784923B2 (en) |
WO (1) | WO2002062368A2 (en) |
Families Citing this family (79)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6136311A (en) | 1996-05-06 | 2000-10-24 | Cornell Research Foundation, Inc. | Treatment and diagnosis of cancer |
PT991403E (en) * | 1997-01-30 | 2003-08-29 | Chiron Corp | USE OF MICROPARTICLES WITH ADSORVED ANTIGEN TO STIMULATE IMMUNE RESPONSES |
US6884435B1 (en) * | 1997-01-30 | 2005-04-26 | Chiron Corporation | Microparticles with adsorbent surfaces, methods of making same, and uses thereof |
US20040202680A1 (en) * | 1997-01-30 | 2004-10-14 | O'hagan Derek | Microparticles with adsorbent surfaces, methods of making same, and uses thereof |
US6977074B2 (en) * | 1997-07-10 | 2005-12-20 | Mannkind Corporation | Method of inducing a CTL response |
US7279462B1 (en) * | 1998-04-27 | 2007-10-09 | Nevagen Llc | Somatic transgene immunization and related methods |
US20030022854A1 (en) * | 1998-06-25 | 2003-01-30 | Dow Steven W. | Vaccines using nucleic acid-lipid complexes |
WO2000054839A2 (en) * | 1999-03-15 | 2000-09-21 | Introgen Therapeutics, Inc. | Dendritic cells transduced with a wild-type self gene elicit potent antitumor immune responses |
ATE501175T1 (en) * | 1999-04-27 | 2011-03-15 | Nevagen Llc | SOMATIC TRANSGENIC IMMUNIZATION AND RELATED METHODS |
AU1013601A (en) | 1999-10-22 | 2001-05-08 | Aventis Pasteur Limited | Method of inducing and/or enhancing an immune response to tumor antigens |
US20030215425A1 (en) * | 2001-12-07 | 2003-11-20 | Simard John J. L. | Epitope synchronization in antigen presenting cells |
ATE346925T1 (en) * | 2000-05-10 | 2006-12-15 | Sanofi Pasteur Ltd | IMMUNOGENIC POLYPEPTIDES ENCODED BY MAGE MINIGENE AND USES THEREOF |
CN100589845C (en) * | 2001-03-07 | 2010-02-17 | 麦康公司 | Anti-neovasculature preparations for cancer |
EP1448588A4 (en) | 2001-10-23 | 2006-10-25 | Psma Dev Company L L C | Psma antibodies and protein multimers |
US20050215472A1 (en) | 2001-10-23 | 2005-09-29 | Psma Development Company, Llc | PSMA formulations and uses thereof |
GB0203276D0 (en) * | 2002-02-12 | 2002-03-27 | Novartis Ag | Organic compounds |
US20030206916A1 (en) * | 2002-05-03 | 2003-11-06 | Rush-Presbyterian-St. Luke's Medical Center | Immunogenic peptides |
DE10225144A1 (en) * | 2002-05-29 | 2003-12-18 | Immatics Biotechnologies Gmbh | Tumor-associated peptides binding to MHC molecules |
CA2510238A1 (en) * | 2002-10-22 | 2004-05-06 | Sanofi Pasteur Limited | Cancer treatment using vaccine and high-dose cytokine |
US7178491B2 (en) * | 2003-06-05 | 2007-02-20 | Caterpillar Inc | Control system and method for engine valve actuator |
JP2007500251A (en) * | 2003-06-13 | 2007-01-11 | ベクトン・ディキンソン・アンド・カンパニー | Improved intradermal delivery of biologically active agents |
US20050079152A1 (en) * | 2003-06-17 | 2005-04-14 | Bot Adrian Ian | Methods of elicit, enhance and sustain immune responses against MHC class I-restricted epitopes, for prophylactic or therapeutic purposes |
EP2338506A3 (en) * | 2003-06-17 | 2011-10-12 | Mannkind Corporation | Combinations of tumor-associated antigens for the treatment of various types of cancers |
PL202927B1 (en) * | 2003-07-20 | 2009-08-31 | Carr Daniel R | Peptide and pharmaceutical composition as well as their therapeutic applications |
JP2007503435A (en) * | 2003-08-26 | 2007-02-22 | ベクトン・ディキンソン・アンド・カンパニー | Intradermal delivery of therapeutics |
WO2005053738A1 (en) * | 2003-11-21 | 2005-06-16 | Institut Pasteur | Recombinant adenylate cyclase toxin of bordetella induces t cell responses against tumoral antigens |
US9090673B2 (en) * | 2003-12-12 | 2015-07-28 | City Of Hope | Synthetic conjugate of CpG DNA and T-help/CTL peptide |
KR20070056042A (en) * | 2004-06-17 | 2007-05-31 | 맨카인드 코포레이션 | Epitope analogs |
US20060008468A1 (en) * | 2004-06-17 | 2006-01-12 | Chih-Sheng Chiang | Combinations of tumor-associated antigens in diagnostics for various types of cancers |
MXPA06014769A (en) * | 2004-06-17 | 2007-03-26 | Mannkind Corp | Improved efficacy of immunotherapy by integrating diagnostic with therapeutic methods. |
US20060159689A1 (en) * | 2004-06-17 | 2006-07-20 | Chih-Sheng Chiang | Combinations of tumor-associated antigens in diagnostics for various types of cancers |
US8425323B2 (en) * | 2004-06-30 | 2013-04-23 | Wms Gaming Inc. | Wagering game with asset trading |
CN101146550B (en) * | 2004-12-29 | 2013-04-17 | 曼康公司 | Use of immunogenicity composition in preparing kit for initiating and enhancing immune responses |
WO2006071983A2 (en) | 2004-12-29 | 2006-07-06 | Mannkind Corporation | Use of compositions comprising various tumor-associated antigens as anti-cancer vaccines |
WO2006071990A2 (en) * | 2004-12-29 | 2006-07-06 | Mannkind Corporation | Methods to bypass cd+4 cells in the induction of an immune response |
EP2351577A1 (en) | 2004-12-29 | 2011-08-03 | Mannkind Corporation | Methods to trigger, maintain and manipulate immune responses by targeted administration of biological response modifiers into lymphoid organs |
BRPI0611795A2 (en) * | 2005-06-17 | 2010-09-28 | Mannkind Corp | multivalent drag-and-amplify immunotherapy for carcinoma |
NZ564359A (en) | 2005-06-17 | 2011-09-30 | Mannkind Corp | Analogs of pepetides corresponding to class I MHC-restricted T cell epitopes |
CN101198620A (en) * | 2005-06-17 | 2008-06-11 | 曼康公司 | Methods and compositions to elicit multivalent immune responses against dominant and subdominant epitopes, expressed on cancer cells and tumor stroma |
CA2523032A1 (en) | 2005-10-07 | 2007-04-07 | Immunovaccine Technologies Inc. | Vaccines for cancer therapy |
CN101355960A (en) | 2005-10-18 | 2009-01-28 | 诺华疫苗和诊断公司 | Mucosal and systemic immunizations with alphavirus replicon particles |
US7855062B2 (en) | 2005-12-14 | 2010-12-21 | The Invention Science Fund I, Llc | Bone cell delivery device |
US9005944B2 (en) | 2005-12-14 | 2015-04-14 | The Invention Science Fund I, Llc | Bone cell delivery device |
US20110172826A1 (en) * | 2005-12-14 | 2011-07-14 | Amodei Dario G | Device including altered microorganisms, and methods and systems of use |
ES2363891T3 (en) | 2006-03-20 | 2011-08-18 | The Regents Of The University Of California | ANTIBODIES AGAINST THE ANTIGEN OF TRONCAL CELLS OF THE PROSTATE (PSCA) GENETICALLY MODIFIED FOR ADDRESSING TO CANCER. |
US8063063B2 (en) * | 2006-03-23 | 2011-11-22 | Novartis Ag | Immunopotentiating compounds |
WO2007109810A2 (en) * | 2006-03-23 | 2007-09-27 | Novartis Ag | Methods for the preparation of imidazole-containing compounds |
EP2357184B1 (en) | 2006-03-23 | 2015-02-25 | Novartis AG | Imidazoquinoxaline compounds as immunomodulators |
JP2009544610A (en) * | 2006-07-14 | 2009-12-17 | マンカインド コーポレイション | Methods for eliciting, enhancing and retaining immune responses against MHC class I restricted epitopes for prophylactic or therapeutic purposes |
US20080095798A1 (en) * | 2006-10-18 | 2008-04-24 | Robert Humphreys | Ii-key enhanced vaccine potency |
ES2384659T3 (en) * | 2007-02-01 | 2012-07-10 | Avantor Performance Materials, Inc. | Solutions for the storage of chromatographic media and chromatographic equipment and their use |
CA2678353A1 (en) | 2007-02-15 | 2008-08-21 | Mannkind Corporation | A method for enhancing t cell response |
US8877206B2 (en) | 2007-03-22 | 2014-11-04 | Pds Biotechnology Corporation | Stimulation of an immune response by cationic lipids |
MX2009012635A (en) * | 2007-05-23 | 2012-09-13 | Mannkind Corp | Multicistronic vectors and methods for their design. |
CA2698343C (en) | 2007-09-04 | 2018-06-12 | The Regents Of The University Of California | High affinity anti-prostate stem cell antigen (psca) antibodies for cancer targeting and detection |
WO2009039628A1 (en) | 2007-09-27 | 2009-04-02 | Immunovaccine Technologies Inc. | Use of liposomes in a carrier comprising a continuous hydrophobic phase for delivery of polynucleotides in vivo |
EP2740490A1 (en) * | 2007-10-03 | 2014-06-11 | Cornell University | Treatment of proliferative disorders using antibodies to PSMA |
ES2712505T3 (en) | 2008-04-17 | 2019-05-13 | Pds Biotechnology Corp | Stimulation of an immune response by enantiomers of cationic lipids |
US20110070298A1 (en) | 2008-06-05 | 2011-03-24 | Immunovaccine Technologies Inc. | Compositions Comprising Liposomes, An Antigen, A Polynucleotide and A Carrier Comprising a Continuous Phase of a Hydrophobic Substance |
US8156070B2 (en) * | 2008-09-05 | 2012-04-10 | Roche Diagnostics Operations, Inc. | Insulin pump programming software with basal profile preview feature |
ES2712732T3 (en) | 2009-02-17 | 2019-05-14 | Cornell Res Foundation Inc | Methods and kits for the diagnosis of cancer and the prediction of therapeutic value |
CA2778707A1 (en) | 2009-10-23 | 2011-04-28 | Mannkind Corporation | Cancer immunotherapy and method of treatment |
EP3135302A1 (en) | 2009-12-02 | 2017-03-01 | Imaginab, Inc. | J591 minibodies and cys-diabodies for targeting human prostate specific membrane antigen (psma) and methods for their use |
JP2013532008A (en) | 2010-05-28 | 2013-08-15 | テトリス オンライン インコーポレイテッド | Interactive hybrid asynchronous computer game infrastructure |
CN113876945A (en) | 2011-10-06 | 2022-01-04 | 免疫疫苗技术有限公司 | Liposome composition comprising adjuvant for activating or increasing TLR2 activity and application thereof |
US9149508B1 (en) * | 2011-10-26 | 2015-10-06 | Sigmovir Biosystems, Inc. | Vaccination by circumventing preexistent immunity |
WO2014047533A1 (en) * | 2012-09-21 | 2014-03-27 | Frank Bedu-Addo | Improved vaccine compositions and methods of use |
WO2014143781A1 (en) | 2013-03-15 | 2014-09-18 | Camas Incorporated | Methods and compositions for reducing microorganisms in the oropharynx, nasopharynx and oral cavities |
KR102132697B1 (en) | 2013-12-05 | 2020-07-10 | 엘지디스플레이 주식회사 | Curved Display Device |
US10816554B2 (en) | 2014-04-04 | 2020-10-27 | The Board Of Trustees Of The Leland Stanford Junior University | Ligand discovery for T cell receptors |
US20150343139A1 (en) * | 2014-05-30 | 2015-12-03 | Boston Scientific Scimed, Inc. | Implantable pumps and related methods of use |
IL293135A (en) | 2015-05-13 | 2022-07-01 | Agenus Inc | Composition comprising at least two different complexes of a purified stress protein bound to an antigenic peptide |
SG10201913625XA (en) | 2015-08-07 | 2020-03-30 | Imaginab Inc | Antigen binding constructs to target molecules |
US11612652B2 (en) | 2015-11-13 | 2023-03-28 | Pds Biotechnology Corporation | Lipids as synthetic vectors to enhance antigen processing and presentation ex-vivo in dendritic cell therapy |
CN109715196A (en) | 2016-06-13 | 2019-05-03 | 转矩医疗股份有限公司 | For promoting the composition and method of immune cell function |
US11266745B2 (en) | 2017-02-08 | 2022-03-08 | Imaginab, Inc. | Extension sequences for diabodies |
US11524033B2 (en) | 2017-09-05 | 2022-12-13 | Torque Therapeutics, Inc. | Therapeutic protein compositions and methods of making and using the same |
MA52363A (en) | 2018-04-26 | 2021-03-03 | Agenus Inc | THERMAL SHOCK PROTEIN (HSP) PEPTIDIC COMPOSITIONS AND THEIR METHODS OF USE |
WO2020186064A1 (en) * | 2019-03-12 | 2020-09-17 | The General Hospital Corporation | Highly networked immunogen composition |
Family Cites Families (144)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3604417A (en) | 1970-03-31 | 1971-09-14 | Wayne Henry Linkenheimer | Osmotic fluid reservoir for osmotically activated long-term continuous injector device |
US3995631A (en) | 1971-01-13 | 1976-12-07 | Alza Corporation | Osmotic dispenser with means for dispensing active agent responsive to osmotic gradient |
US4034756A (en) | 1971-01-13 | 1977-07-12 | Alza Corporation | Osmotically driven fluid dispenser |
US3760805A (en) | 1971-01-13 | 1973-09-25 | Alza Corp | Osmotic dispenser with collapsible supply container |
US3732865A (en) | 1971-01-13 | 1973-05-15 | Alza Corp | Osmotic dispenser |
US3760804A (en) | 1971-01-13 | 1973-09-25 | Alza Corp | Improved osmotic dispenser employing magnesium sulphate and magnesium chloride |
US3760984A (en) | 1971-09-29 | 1973-09-25 | Alza Corp | Osmotically powered agent dispensing device with filling means |
US3929132A (en) | 1973-04-10 | 1975-12-30 | Alza Corp | Osmotic dispenser |
US3995632A (en) | 1973-05-04 | 1976-12-07 | Alza Corporation | Osmotic dispenser |
US3987790A (en) | 1975-10-01 | 1976-10-26 | Alza Corporation | Osmotically driven fluid dispenser |
US4203440A (en) | 1978-10-23 | 1980-05-20 | Alza Corporation | Device having variable volume chamber for dispensing useful agent |
US4286067A (en) | 1978-10-23 | 1981-08-25 | Alza Corporation | Article of manufacture comprising semipermeable polymer and dextran derivative |
US4304232A (en) | 1979-03-14 | 1981-12-08 | Alza Corporation | Unit system having multiplicity of means for dispensing useful agent |
US4450198A (en) | 1980-01-28 | 1984-05-22 | Alza Corporation | Microporous film with polymer in pores for regulating passage of fluid |
US4439199A (en) | 1980-02-19 | 1984-03-27 | Alza Corporation | Method for administering immunopotentiator |
US4455142A (en) * | 1980-07-07 | 1984-06-19 | Alza Corporation | Method of coadministering an antigen and an immunopotentiator |
US4300558A (en) | 1980-07-18 | 1981-11-17 | Alza Corporation | Self-driven fluid dispenser |
US4350271A (en) | 1980-08-22 | 1982-09-21 | Alza Corporation | Water absorbing fluid dispenser |
US4367741A (en) | 1980-12-22 | 1983-01-11 | Alza Corporation | Dispenser powered by cross-linked hydrophilic polymer grafted to hydrophilic polymer |
US4340054A (en) | 1980-12-29 | 1982-07-20 | Alza Corporation | Dispenser for delivering fluids and solids |
IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
US4340048A (en) | 1981-03-28 | 1982-07-20 | Alza Corporation | Self-driven hypodermic injector |
US4455145A (en) | 1981-07-10 | 1984-06-19 | Alza Corporation | Dispensing device with internal drive |
IT1142930B (en) | 1981-11-04 | 1986-10-15 | Luigi Bernardi | PORTABLE APPARATUS THAT INFUSES INSULIN ON THE BASIS OF GLYCEMIC DETECTION |
US4474575A (en) | 1982-02-01 | 1984-10-02 | Alza Corporation | Self-driven pump assembly and method of operation |
US4435173A (en) | 1982-03-05 | 1984-03-06 | Delta Medical Industries | Variable rate syringe pump for insulin delivery |
US4778879A (en) | 1982-04-20 | 1988-10-18 | Sloan-Kettering Institute For Cancer Research | Highly purified human interleukin 2 and method |
US4498843A (en) | 1982-08-02 | 1985-02-12 | Schneider Philip H | Insulin infusion pump |
US4753651A (en) | 1982-08-30 | 1988-06-28 | Alza Corporation | Self-driven pump |
US4619652A (en) | 1982-12-23 | 1986-10-28 | Alza Corporation | Dosage form for use in a body mounted pump |
US4561856A (en) | 1983-08-18 | 1985-12-31 | Cochran Ulrich D | Infusion pump |
US4552651A (en) | 1983-11-14 | 1985-11-12 | Conoco Inc. | Control of froth cell performance through the use of differential bubbler tubes |
US4855238A (en) | 1983-12-16 | 1989-08-08 | Genentech, Inc. | Recombinant gamma interferons having enhanced stability and methods therefor |
US4908433A (en) | 1984-04-25 | 1990-03-13 | Sloan-Kettering Institute For Cancer Research | Uses of interleukin-2 |
NL8403937A (en) | 1984-12-24 | 1986-07-16 | Cornelis Smit | DEVICE FOR DELIVERING A NUMBER OF LIQUID DOSES. |
DE3937412A1 (en) | 1989-11-10 | 1991-05-16 | Hoechst Ag | SYNTHETIC VACCINE FOR THE SPECIFIC INDUCTION OF CYTOTOXIC T-LYMPHOZYTES |
US4865598A (en) | 1985-08-16 | 1989-09-12 | Alza Corporation | Dispensing system for administering beneficial agent |
US4963141A (en) | 1985-08-16 | 1990-10-16 | Alza Corporation | Dispensing system for administering beneficial agent formulation to ruminants |
US4865845A (en) | 1986-03-21 | 1989-09-12 | Alza Corporation | Release rate adjustment of osmotic or diffusional delivery devices |
US5019384A (en) * | 1986-06-30 | 1991-05-28 | Massachusetts Institute Of Technology | Immunonodulating compositions and their use |
US4838862A (en) | 1986-08-04 | 1989-06-13 | Pharmetrix Corp. | Portable controlled release osmotic infusion device |
DE3700119A1 (en) * | 1987-01-03 | 1988-07-14 | Inst Diabetestechnologie Gemei | IMPLANTABLE ELECTROCHEMICAL SENSOR |
US5023088A (en) | 1987-06-25 | 1991-06-11 | Alza Corporation | Multi-unit delivery system |
US5110597A (en) | 1987-06-25 | 1992-05-05 | Alza Corporation | Multi-unit delivery system |
GB2211132B (en) * | 1987-10-22 | 1991-08-14 | Gore & Ass | Bagpipes and a pipe bag therefor |
US4872873A (en) | 1987-12-14 | 1989-10-10 | Merck & Co., Inc. | Controlled release bolus device |
US4855141A (en) | 1988-03-25 | 1989-08-08 | Alza Corporation | Device comprising means for protecting and dispensing fluid sensitive medicament |
US5804381A (en) | 1996-10-03 | 1998-09-08 | Cornell Research Foundation | Isolated nucleic acid molecule encoding an esophageal cancer associated antigen, the antigen itself, and uses thereof |
US4898582A (en) | 1988-08-09 | 1990-02-06 | Pharmetrix Corporation | Portable infusion device assembly |
US4929233A (en) | 1988-08-26 | 1990-05-29 | Alza Corporation | Implantable fluid imbibing pump with improved closure |
US5135523A (en) | 1988-12-13 | 1992-08-04 | Alza Corporation | Delivery system for administering agent to ruminants and swine |
US5174999A (en) | 1988-12-13 | 1992-12-29 | Alza Corporation | Delivery system comprising fluid ingress and drug egress |
US5057318A (en) | 1988-12-13 | 1991-10-15 | Alza Corporation | Delivery system for beneficial agent over a broad range of rates |
US5059423A (en) | 1988-12-13 | 1991-10-22 | Alza Corporation | Delivery system comprising biocompatible beneficial agent formulation |
US5034229A (en) | 1988-12-13 | 1991-07-23 | Alza Corporation | Dispenser for increasing feed conversion of hog |
US5110596A (en) | 1988-12-13 | 1992-05-05 | Alza Corporation | Delivery system comprising means for delivering agent to livestock |
US5037420A (en) | 1988-12-13 | 1991-08-06 | Alza Corporation | Delivery system comprising two sections for delivering somatotropin |
US4976966A (en) | 1988-12-29 | 1990-12-11 | Alza Corporation | Delayed release osmotically driven fluid dispenser |
PL159857B1 (en) | 1989-01-20 | 1993-01-29 | Method for the continuous control of the carried infusion microbatcher | |
US4929141A (en) * | 1989-02-21 | 1990-05-29 | International Baler Corp. | Bale-opening method and apparatus |
US6214804B1 (en) | 1989-03-21 | 2001-04-10 | Vical Incorporated | Induction of a protective immune response in a mammal by injecting a DNA sequence |
US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
US5328470A (en) * | 1989-03-31 | 1994-07-12 | The Regents Of The University Of Michigan | Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor |
US5110598A (en) * | 1989-06-30 | 1992-05-05 | Smithkline Beecham Corp. | Intermittent release dosage form |
US5030216A (en) | 1989-12-15 | 1991-07-09 | Alza Corporation | Osmotically driven syringe |
US5135498A (en) | 1990-04-02 | 1992-08-04 | Kam Robert J | Controlled release infusion device |
US5017381A (en) | 1990-05-02 | 1991-05-21 | Alza Corporation | Multi-unit pulsatile delivery system |
US5257987A (en) | 1990-05-21 | 1993-11-02 | Pharmetrix Corporation | Controlled release osmotic infusion system |
US5169390A (en) | 1990-05-21 | 1992-12-08 | Athayde Amulya L | Osmotic infusion device |
AU8074591A (en) | 1990-06-15 | 1992-01-07 | Cortrak Medical, Inc. | Drug delivery apparatus and method |
US5766601A (en) * | 1990-08-08 | 1998-06-16 | University Of Massachusetts Medical Center | Cross-reactive influenza a immunization |
US5830452A (en) * | 1990-11-20 | 1998-11-03 | Chiron Corporation | Method for enhancing the anti-tumor therapeutic index of interleukin-2 |
GB9027422D0 (en) * | 1990-12-18 | 1991-02-06 | Scras | Osmotically driven infusion device |
DE4143467C2 (en) | 1991-05-17 | 1995-02-09 | Max Planck Gesellschaft | Peptide motif and its use |
US5137727A (en) | 1991-06-12 | 1992-08-11 | Alza Corporation | Delivery device providing beneficial agent stability |
US5451504A (en) | 1991-07-29 | 1995-09-19 | Serex, Inc. | Method and device for detecting the presence of analyte in a sample |
US6419931B1 (en) * | 1991-08-26 | 2002-07-16 | Epimmune Inc. | Compositions and methods for eliciting CTL immunity |
US5304165A (en) | 1991-12-09 | 1994-04-19 | Habley Medical Technology Corporation | Syringe-filling medication dispenser |
US5223265A (en) | 1992-01-10 | 1993-06-29 | Alza Corporation | Osmotic device with delayed activation of drug delivery |
US6037135A (en) | 1992-08-07 | 2000-03-14 | Epimmune Inc. | Methods for making HLA binding peptides and their uses |
US5209746A (en) | 1992-02-18 | 1993-05-11 | Alza Corporation | Osmotically driven delivery devices with pulsatile effect |
US5221278A (en) | 1992-03-12 | 1993-06-22 | Alza Corporation | Osmotically driven delivery device with expandable orifice for pulsatile delivery effect |
DE4238416A1 (en) | 1992-11-13 | 1994-05-19 | Max Planck Gesellschaft | Determination of peptide motifs on MHC molecules |
US5744316A (en) | 1992-12-22 | 1998-04-28 | Ludwig Institute For Cancer Research | Isolated, tyrosinase derived peptides and uses thereof |
US6077519A (en) * | 1993-01-29 | 2000-06-20 | University Of Pittsburgh | Methods for isolation and use of T cell epitopes eluted from viable cells in vaccines for treating cancer patients |
WO1994018954A1 (en) | 1993-02-22 | 1994-09-01 | Vivorx Pharmaceuticals, Inc. | Methods for in vivo delivery of biologics and compositions useful therefor |
WO1994021680A1 (en) | 1993-03-17 | 1994-09-29 | The Government Of The United States Of America As | Immunogenic chimeras comprising nucleic acid sequences encoding endoplasmic reticulum signal sequence peptides and at least one other peptide, and their uses in vaccines and disease treatments |
US6284727B1 (en) * | 1993-04-07 | 2001-09-04 | Scios, Inc. | Prolonged delivery of peptides |
US5409710A (en) * | 1993-04-20 | 1995-04-25 | Endocon, Inc. | Foam cell drug delivery |
US5696079A (en) * | 1993-05-19 | 1997-12-09 | The United States Of America As Represented By The Department Of Health And Human Services | Immunologic enhancement with intermittent interleukin-2 therapy |
US5368562A (en) | 1993-07-30 | 1994-11-29 | Pharmacia Deltec, Inc. | Systems and methods for operating ambulatory medical devices such as drug delivery devices |
US5595871A (en) * | 1993-08-25 | 1997-01-21 | University Of Scranton | Detection and prevention of mycoplasma hominis infection |
US5679647A (en) | 1993-08-26 | 1997-10-21 | The Regents Of The University Of California | Methods and devices for immunizing a host against tumor-associated antigens through administration of naked polynucleotides which encode tumor-associated antigenic peptides |
KR100372375B1 (en) | 1993-12-23 | 2003-04-21 | 머클한스피터 | Immunological response potentiation process |
US5700823A (en) | 1994-01-07 | 1997-12-23 | Sugen, Inc. | Treatment of platelet derived growth factor related disorders such as cancers |
US5550214A (en) * | 1994-02-10 | 1996-08-27 | Brigham And Women's Hospital | Isolated antigenic oncogene peptide fragments and uses |
US5478556A (en) | 1994-02-28 | 1995-12-26 | Elliott; Robert L. | Vaccination of cancer patients using tumor-associated antigens mixed with interleukin-2 and granulocyte-macrophage colony stimulating factor |
US5496360A (en) | 1994-04-12 | 1996-03-05 | Ventritex, Inc. | Implantable cardiac electrode with rate controlled drug delivery |
DE4423392A1 (en) | 1994-07-04 | 1996-01-11 | Birsner & Grob Biotech Gmbh | Methods of identifying antigenic peptides |
US5626862A (en) | 1994-08-02 | 1997-05-06 | Massachusetts Institute Of Technology | Controlled local delivery of chemotherapeutic agents for treating solid tumors |
EP0812355A2 (en) | 1995-02-28 | 1997-12-17 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Berlin | Agent for treating tumours and other hyperplasia |
US5962428A (en) | 1995-03-30 | 1999-10-05 | Apollon, Inc. | Compositions and methods for delivery of genetic material |
US5935568A (en) | 1995-05-18 | 1999-08-10 | National Jewish Medical & Research Center | Gene therapy for effector cell regulation |
US5698396A (en) | 1995-06-07 | 1997-12-16 | Ludwig Institute For Cancer Research | Method for identifying auto-immunoreactive substances from a subject |
US5900238A (en) | 1995-07-27 | 1999-05-04 | Immunex Corporation | Vaccine delivery system |
JPH09151200A (en) | 1995-09-29 | 1997-06-10 | Ajinomoto Co Inc | Peptide capable of inducing immune response to human gastric cancer, therapeutic and preventive agent for human gastric cancer containing the same |
US5853719A (en) * | 1996-04-30 | 1998-12-29 | Duke University | Methods for treating cancers and pathogen infections using antigen-presenting cells loaded with RNA |
NZ333203A (en) | 1996-06-07 | 2000-07-28 | Kyogo Itoh | Tumour antigen proteins, genes thereof, and tumour antigen peptides |
US5837231A (en) * | 1996-06-27 | 1998-11-17 | Regents Of The University Of Minnesota | GM-CSF administration for the treatment and prevention of recurrence of brain tumors |
US5951975A (en) | 1996-06-28 | 1999-09-14 | University Of Pittsburgh | Induction of CTLs specific for natural antigens by cross priming immunization |
US5876972A (en) | 1996-09-23 | 1999-03-02 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Nucleic acid molecules coding for tumor suppressor proteins and methods for their isolation |
US5910306A (en) | 1996-11-14 | 1999-06-08 | The United States Of America As Represented By The Secretary Of The Army | Transdermal delivery system for antigen |
US6204250B1 (en) * | 1996-11-22 | 2001-03-20 | The Mount Sinai Medical Center Of The City Of New York | Immunization of infants |
ATE203157T1 (en) | 1996-12-20 | 2001-08-15 | Alza Corp | INJECTABLE DEPOSIT GEL PREPARATION AND PRODUCTION METHOD |
PT973499E (en) | 1997-03-31 | 2003-12-31 | Alza Corp | IMPLANTABLE DIFFUSER ADMINISTRATION SYSTEM |
US6994851B1 (en) * | 1997-07-10 | 2006-02-07 | Mannkind Corporation | Method of inducing a CTL response |
PT1003548E (en) * | 1997-07-10 | 2006-09-29 | Mannkind Corp | DEVICE FOR THE INDUCTION OF A CTL RESPONSE |
US6977074B2 (en) | 1997-07-10 | 2005-12-20 | Mannkind Corporation | Method of inducing a CTL response |
US6709844B1 (en) | 2000-11-16 | 2004-03-23 | Mannkind Corporation | Avoidance of undesirable replication intermediates in plasmid propagation |
US20030138808A1 (en) | 1998-02-19 | 2003-07-24 | Simard John J.L. | Expression vectors encoding epitopes of target-associated antigens |
US6861234B1 (en) | 2000-04-28 | 2005-03-01 | Mannkind Corporation | Method of epitope discovery |
US20030215425A1 (en) | 2001-12-07 | 2003-11-20 | Simard John J. L. | Epitope synchronization in antigen presenting cells |
CA2405363A1 (en) | 2000-04-28 | 2001-11-08 | Ctl Immunotherapies Corp. | Epitope synchronization in antigen presenting cells |
CN100589845C (en) | 2001-03-07 | 2010-02-17 | 麦康公司 | Anti-neovasculature preparations for cancer |
WO2003008537A2 (en) * | 2001-04-06 | 2003-01-30 | Mannkind Corporation | Epitope sequences |
ES2358642T3 (en) | 2001-11-07 | 2011-05-12 | Mannkind Corporation | EXPRESSION VECTORS CODING ANTIGENS EPITHOPES AND METHODS FOR THEIR DESIGN. |
JP2005537800A (en) * | 2002-09-06 | 2005-12-15 | マンカインド コーポレイション | Epitope sequence |
US20050079152A1 (en) | 2003-06-17 | 2005-04-14 | Bot Adrian Ian | Methods of elicit, enhance and sustain immune responses against MHC class I-restricted epitopes, for prophylactic or therapeutic purposes |
EP2338506A3 (en) | 2003-06-17 | 2011-10-12 | Mannkind Corporation | Combinations of tumor-associated antigens for the treatment of various types of cancers |
US20060159689A1 (en) * | 2004-06-17 | 2006-07-20 | Chih-Sheng Chiang | Combinations of tumor-associated antigens in diagnostics for various types of cancers |
KR20070056042A (en) | 2004-06-17 | 2007-05-31 | 맨카인드 코포레이션 | Epitope analogs |
MXPA06014769A (en) | 2004-06-17 | 2007-03-26 | Mannkind Corp | Improved efficacy of immunotherapy by integrating diagnostic with therapeutic methods. |
US20060008468A1 (en) * | 2004-06-17 | 2006-01-12 | Chih-Sheng Chiang | Combinations of tumor-associated antigens in diagnostics for various types of cancers |
US7678050B2 (en) * | 2004-08-24 | 2010-03-16 | General Electric Company | Method and apparatus for detecting cardiac events |
WO2006071983A2 (en) * | 2004-12-29 | 2006-07-06 | Mannkind Corporation | Use of compositions comprising various tumor-associated antigens as anti-cancer vaccines |
CN101146550B (en) | 2004-12-29 | 2013-04-17 | 曼康公司 | Use of immunogenicity composition in preparing kit for initiating and enhancing immune responses |
EP2351577A1 (en) | 2004-12-29 | 2011-08-03 | Mannkind Corporation | Methods to trigger, maintain and manipulate immune responses by targeted administration of biological response modifiers into lymphoid organs |
WO2006071990A2 (en) | 2004-12-29 | 2006-07-06 | Mannkind Corporation | Methods to bypass cd+4 cells in the induction of an immune response |
BRPI0611795A2 (en) | 2005-06-17 | 2010-09-28 | Mannkind Corp | multivalent drag-and-amplify immunotherapy for carcinoma |
CN101198620A (en) | 2005-06-17 | 2008-06-11 | 曼康公司 | Methods and compositions to elicit multivalent immune responses against dominant and subdominant epitopes, expressed on cancer cells and tumor stroma |
NZ564359A (en) | 2005-06-17 | 2011-09-30 | Mannkind Corp | Analogs of pepetides corresponding to class I MHC-restricted T cell epitopes |
JP2009544610A (en) * | 2006-07-14 | 2009-12-17 | マンカインド コーポレイション | Methods for eliciting, enhancing and retaining immune responses against MHC class I restricted epitopes for prophylactic or therapeutic purposes |
CA2678353A1 (en) | 2007-02-15 | 2008-08-21 | Mannkind Corporation | A method for enhancing t cell response |
MX2009012635A (en) | 2007-05-23 | 2012-09-13 | Mannkind Corp | Multicistronic vectors and methods for their design. |
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- 2001-12-21 AU AU97432/01A patent/AU784923B2/en not_active Ceased
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2002
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US20120046638A1 (en) | 2012-02-23 |
US8372393B2 (en) | 2013-02-12 |
US6977074B2 (en) | 2005-12-20 |
US20060153858A1 (en) | 2006-07-13 |
US7364729B2 (en) | 2008-04-29 |
AU9743201A (en) | 2002-08-08 |
US20020007173A1 (en) | 2002-01-17 |
AU784923B2 (en) | 2006-07-27 |
AU2002247023A1 (en) | 2002-08-19 |
US20090035252A1 (en) | 2009-02-05 |
WO2002062368A3 (en) | 2003-09-25 |
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