WO2002065993A3 - Use of aryl nitrone compounds in methods for treating neuropathic pain - Google Patents

Use of aryl nitrone compounds in methods for treating neuropathic pain Download PDF

Info

Publication number
WO2002065993A3
WO2002065993A3 PCT/US2002/000758 US0200758W WO02065993A3 WO 2002065993 A3 WO2002065993 A3 WO 2002065993A3 US 0200758 W US0200758 W US 0200758W WO 02065993 A3 WO02065993 A3 WO 02065993A3
Authority
WO
WIPO (PCT)
Prior art keywords
neuropathic pain
methods
treating neuropathic
nitrone compounds
aryl nitrone
Prior art date
Application number
PCT/US2002/000758
Other languages
French (fr)
Other versions
WO2002065993A2 (en
Inventor
David Waterbury
Paul L Wood
M Amin Khan
Ravindra B Upasani
Original Assignee
Centaur Pharmaceuticals Inc
David Waterbury
Paul L Wood
M Amin Khan
Ravindra B Upasani
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centaur Pharmaceuticals Inc, David Waterbury, Paul L Wood, M Amin Khan, Ravindra B Upasani filed Critical Centaur Pharmaceuticals Inc
Priority to AU2002253857A priority Critical patent/AU2002253857A1/en
Publication of WO2002065993A2 publication Critical patent/WO2002065993A2/en
Publication of WO2002065993A3 publication Critical patent/WO2002065993A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof

Abstract

3, 4, 5-trisubstituted aryl nitrone compounds are useful as therapeutics for neuropathic pain conditions in mammals.
PCT/US2002/000758 2001-01-08 2002-01-08 Use of aryl nitrone compounds in methods for treating neuropathic pain WO2002065993A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002253857A AU2002253857A1 (en) 2001-01-08 2002-01-08 Use of aryl nitrone compounds in methods for treating neuropathic pain

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26046901P 2001-01-08 2001-01-08
US60/260,469 2001-01-08

Publications (2)

Publication Number Publication Date
WO2002065993A2 WO2002065993A2 (en) 2002-08-29
WO2002065993A3 true WO2002065993A3 (en) 2002-11-07

Family

ID=22989290

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/000758 WO2002065993A2 (en) 2001-01-08 2002-01-08 Use of aryl nitrone compounds in methods for treating neuropathic pain

Country Status (3)

Country Link
US (2) US6835754B2 (en)
AU (1) AU2002253857A1 (en)
WO (1) WO2002065993A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050107366A1 (en) * 1991-06-18 2005-05-19 Carney John M. Spin trapping pharmaceutical compositions and methods for use thereof
US7115666B2 (en) * 2002-10-15 2006-10-03 Renovis, Inc. Nitrone compounds, pharmaceutical compositions containing the same and methods for treating inflammation and neuropathic pain
US20050059638A1 (en) * 2003-08-04 2005-03-17 Kelly Michael G. Aryl, heteroaromatic and bicyclic aryl nitrone compounds, prodrugs and pharmaceutical compositions of the same to treat human disorders
US20050182060A1 (en) * 2004-02-13 2005-08-18 Kelly Michael G. 2-Substituted and 4-substituted aryl nitrone compounds
WO2005087214A1 (en) * 2004-03-09 2005-09-22 Renovis, Inc. Methods for treating multiple sclerosis and pharmaceutical compositions therefor
BRPI0418932A (en) * 2004-06-29 2007-11-27 Lundbeck & Co As H use of gaboxadol or a pharmaceutically acceptable salt thereof, and method for treating neuropathic pain, fibromyalgia, or rheumatoid arthritis
ES2367330T3 (en) * 2007-11-15 2011-11-02 Rohm And Haas Company NITRON PREPARATION.
JP4996575B2 (en) * 2007-11-15 2012-08-08 ローム アンド ハース カンパニー Nitron manufacturing
US8778969B2 (en) 2009-11-07 2014-07-15 Peter H Proctor Nitrone, nitroso, and nitroxide spintraps and spin labels and their hydroxylamines
CN104803880B (en) * 2014-01-23 2017-11-21 广州喜鹊医药有限公司 Compound with neuroprotective effect and preparation method and application thereof
US9701625B2 (en) 2014-03-07 2017-07-11 Dow Global Technologies Llc Nitrone compounds and their use in personal care
EP3142752B1 (en) 2014-05-12 2018-06-20 Dow Global Technologies Llc Nitrone compounds and their use in personal care
CN106471024B (en) 2014-06-30 2019-06-04 陶氏环球技术有限责任公司 It polymerize nitrone and its purposes in personal nursing
BR112017018503B1 (en) 2015-03-20 2021-08-24 Dow Global Technologies Llc COMPOSITION OF PERSONAL CARE
JP6734295B2 (en) 2015-03-20 2020-08-05 ダウ グローバル テクノロジーズ エルエルシー Nitron inhibition of unsaturated fat oxidation

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5455272A (en) * 1993-10-22 1995-10-03 Oklahoma Medical Research Foundation Spin trap nitronyl hindered phenols
US6342523B1 (en) * 1998-12-02 2002-01-29 Centaur Pharmaceuticals, Inc. 3,4,5-trisubstituted aryl nitrone compounds, pharmaceutical compositions containing the same and methods for treating inflammation

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US366754A (en) * 1887-07-19 Albert aemstbong
US3666754A (en) 1965-11-06 1972-05-30 Dainippon Pharmaceutical Co 2-(5-nitrofuryl) nitrone derivatives
US3849934A (en) 1971-05-03 1974-11-26 Scm Corp Alpha-aryl-n-lower alkyl nitrone-containing compositions useful as anti-fungal agents
US3834073A (en) 1971-05-03 1974-09-10 Scm Corp Phenyl nitrone derivatives useful as seed protectants
US3903049A (en) 1974-01-30 1975-09-02 Goodyear Tire & Rubber Oxidation resistant sulfur curable rubbery polymers
US3917700A (en) 1974-01-30 1975-11-04 Goodyear Tire & Rubber Nitrone compounds
IT1133010B (en) 1980-05-15 1986-07-09 Sigma Tau Ind Farmaceuti THERAPUETIC METHOD FOR THE TREATMENT OF DIABETES AT YOUTH ONCE AND PHARMACEUTICAL COMPOSITION FOR THIS METHOD
GB2137619A (en) 1983-03-30 1984-10-10 Gerald Scott Nitrone compounds and stabilised rubber compositions containing them
US5723502A (en) 1985-07-18 1998-03-03 Proctor; Peter H. Topical spin trap composition and method
US5352442A (en) 1985-07-18 1994-10-04 Proctor Peter H Topical tempo
DE68917946T2 (en) 1988-01-29 1995-01-05 Peter H Proctor Hair growth stimulation with nitroxyd and other radicals.
EP0496796B1 (en) 1989-10-17 1994-08-31 Oklahoma Medical Research Foundation Method and compositions for inhibition of disorders associated with oxidative damage
ATE209908T1 (en) 1991-06-18 2001-12-15 Oklahoma Med Res Found RADICAL CAPTURER (ßSPIN TRAPSß) FOR THE TREATMENT OF DISEASES ASSOCIATED WITH OXIDATION OF LIPIDS AND PROTEINS
US5292746A (en) 1991-09-12 1994-03-08 Merrell Dow Pharmaceuticals Inc. Cyclic nitrones, pharmaceutical compositions thereof and their use in treating shock
US5488145A (en) 1993-12-23 1996-01-30 Oklahoma Medical Research Foundation 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceutical free radical traps
ATE349420T1 (en) 1995-11-17 2007-01-15 Florida Internat University AZULENYL NITRONES AS RADICAL CATCHERS (SPIN TRAPPING AGENTS), METHOD FOR THEIR PRODUCTION AND THEIR APPLICATION
US5732502A (en) * 1995-12-19 1998-03-31 Hansen; Paul E. Fishing lure
TW429241B (en) 1996-09-26 2001-04-11 Sumitomo Pharma Nitrone derivatives
US6046232A (en) 1997-10-17 2000-04-04 Centaur Pharmaceuticals, Inc. α-aryl-N-alkylnitrones and pharmaceutical compositions containing the same

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5455272A (en) * 1993-10-22 1995-10-03 Oklahoma Medical Research Foundation Spin trap nitronyl hindered phenols
US6342523B1 (en) * 1998-12-02 2002-01-29 Centaur Pharmaceuticals, Inc. 3,4,5-trisubstituted aryl nitrone compounds, pharmaceutical compositions containing the same and methods for treating inflammation

Also Published As

Publication number Publication date
US20020165274A1 (en) 2002-11-07
WO2002065993A2 (en) 2002-08-29
US20040209958A1 (en) 2004-10-21
AU2002253857A1 (en) 2002-09-04
US6835754B2 (en) 2004-12-28

Similar Documents

Publication Publication Date Title
WO2002065993A3 (en) Use of aryl nitrone compounds in methods for treating neuropathic pain
WO2001060347A3 (en) Method for treating ocular pain
WO2002103103A3 (en) Fluorine-containing compounds and polymers derived therefrom
WO2003093269A3 (en) Substituted pyrazolo-pyrimidine-4-ones
GB0125222D0 (en) Composition for the treatment of microbial infections
MY138966A (en) 2-oxo-1-pyrrolidine derivatives, processes for preparing them and their uses
ATE410430T1 (en) 2,3-DIHYDRO-6-NITROIMIDAZOÄ2,1-BUOXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS
MX338829B (en) Method for preparing 3-halo-4,5-dihydro-1h-pyrazoles.
WO2006003492A3 (en) Compositions and methods for treating pathological infections
WO2004080391A3 (en) Novel antibacterial agents
WO2001052847A8 (en) Thiazole, imidazole and oxazole compounds and treatments of disorders associated with protein aging
PL371127A1 (en) 6-aminomorphinane derivatives, method for the production and use thereof
AU5915100A (en) Albumin-binding compounds that prevent nonenzymatic glycation and that may be used for treatment of glycation-related pathologies
MY133969A (en) Indoloquinazolinones
EP1179528A3 (en) Fungicidal phenylamidine derivatives
WO2004087073A3 (en) Treatment of demyelinating conditions
MXPA02011039A (en) Fungicidal combinations of active agents.
WO2003053971A8 (en) Pyridoquinoxaline antivirals
WO2005040121A3 (en) Amides that inhibit vanilloid receptor subtype 1 (vr1) receptor
MXPA03008205A (en) Process for the preparation of imidazole compounds.
WO2003072541A3 (en) Chemical compounds
WO2001028493A3 (en) Small molecule inhibitors of necrosis
AU2001278716A1 (en) Method of inhibiting antibody-containing solution from coagulating or becoming turbid
WO2004034961A3 (en) Antimicrobial agents and uses thereof
WO2005005382A3 (en) Compounds, compositions and methods

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG US UZ VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG US UZ VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP