WO2002068932A3 - Methods for providing extended dynamic range in analyte assays - Google Patents

Methods for providing extended dynamic range in analyte assays Download PDF

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Publication number
WO2002068932A3
WO2002068932A3 PCT/US2002/005928 US0205928W WO02068932A3 WO 2002068932 A3 WO2002068932 A3 WO 2002068932A3 US 0205928 W US0205928 W US 0205928W WO 02068932 A3 WO02068932 A3 WO 02068932A3
Authority
WO
WIPO (PCT)
Prior art keywords
dynamic range
methods
extended dynamic
providing extended
analyte assays
Prior art date
Application number
PCT/US2002/005928
Other languages
French (fr)
Other versions
WO2002068932A2 (en
Inventor
Juan Yguerabide
Evangelina Yguerabide
Laurence Warden
Todd Peterson
Original Assignee
Genicon Sciences Corp
Juan Yguerabide
Evangelina Yguerabide
Laurence Warden
Todd Peterson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genicon Sciences Corp, Juan Yguerabide, Evangelina Yguerabide, Laurence Warden, Todd Peterson filed Critical Genicon Sciences Corp
Priority to AU2002245537A priority Critical patent/AU2002245537B2/en
Priority to JP2002567802A priority patent/JP2005507489A/en
Priority to CA002439307A priority patent/CA2439307A1/en
Priority to EP02713700A priority patent/EP1488208A4/en
Publication of WO2002068932A2 publication Critical patent/WO2002068932A2/en
Publication of WO2002068932A3 publication Critical patent/WO2002068932A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1468—Electro-optical investigation, e.g. flow cytometers with spatial resolution of the texture or inner structure of the particle
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

Methods for enhancing the dynamic range for specific detection of one or more analytes in assays using scattered-light detectable particle labels. The methods involve utilizing variations in detection technique and/or signal processing to extend the dynamic range to either or both of lower and higher concentrations.
PCT/US2002/005928 2001-02-23 2002-02-25 Methods for providing extended dynamic range in analyte assays WO2002068932A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2002245537A AU2002245537B2 (en) 2001-02-23 2002-02-25 Methods for providing extended dynamic range in analyte assays
JP2002567802A JP2005507489A (en) 2001-02-23 2002-02-25 How to provide extended dynamic range in sample analysis
CA002439307A CA2439307A1 (en) 2001-02-23 2002-02-25 Methods for providing extended dynamic range in analyte assays
EP02713700A EP1488208A4 (en) 2001-02-23 2002-02-25 Methods for providing extended dynamic range in analyte assays

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27108901P 2001-02-23 2001-02-23
US60/271,089 2001-02-23

Publications (2)

Publication Number Publication Date
WO2002068932A2 WO2002068932A2 (en) 2002-09-06
WO2002068932A3 true WO2002068932A3 (en) 2004-10-07

Family

ID=23034144

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/005928 WO2002068932A2 (en) 2001-02-23 2002-02-25 Methods for providing extended dynamic range in analyte assays

Country Status (6)

Country Link
US (2) US7361472B2 (en)
EP (1) EP1488208A4 (en)
JP (2) JP2005507489A (en)
AU (1) AU2002245537B2 (en)
CA (1) CA2439307A1 (en)
WO (1) WO2002068932A2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8918161B2 (en) 1999-10-06 2014-12-23 Becton, Dickinson And Company Methods of use for surface enhanced spectroscopy-active composite nanoparticles
US9201013B2 (en) 1999-10-06 2015-12-01 Becton, Dickinson And Company Method for tagging material with surface-enhanced spectroscopy (SES)-active composite nanoparticles
US9297766B2 (en) 2001-01-26 2016-03-29 Becton, Dickinson And Company Method of tagging materials with surface-enhanced spectroscopy-active sandwich particles

Families Citing this family (127)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6586193B2 (en) * 1996-04-25 2003-07-01 Genicon Sciences Corporation Analyte assay using particulate labels
US20040109077A1 (en) * 1999-06-17 2004-06-10 Abdellatif Mohammed A. Camera, imaging system and illuminations sensor
AU2002245537B2 (en) 2001-02-23 2007-12-20 Genicon Sciences Corporation Methods for providing extended dynamic range in analyte assays
US20030049866A1 (en) * 2001-09-05 2003-03-13 Genicon Sciences Corporation Sample device preservation
US20040234898A1 (en) * 2002-02-06 2004-11-25 Batishko Charles R. Magnetic flowcell systems and methods
US7122384B2 (en) * 2002-11-06 2006-10-17 E. I. Du Pont De Nemours And Company Resonant light scattering microparticle methods
US7053783B2 (en) 2002-12-18 2006-05-30 Biovigilant Systems, Inc. Pathogen detector system and method
EP1599609B1 (en) * 2003-02-13 2009-11-11 The Regents of The University of California Methods and compositions for detection and analysis of polynucleotide-binding protein interactions using light harvesting multichromophores
US7522762B2 (en) * 2003-04-16 2009-04-21 Inverness Medical-Biostar, Inc. Detection, resolution, and identification of arrayed elements
DE10347123B4 (en) * 2003-10-02 2005-07-28 Petra Dr.-Ing. Perner Method for the automatic determination of airborne particles collected on a carrier, in particular fungal spores
US20050141843A1 (en) * 2003-12-31 2005-06-30 Invitrogen Corporation Waveguide comprising scattered light detectable particles
US7362432B2 (en) 2004-01-14 2008-04-22 Luminex Corp. Method and systems for dynamic range expansion
GB2424269A (en) * 2004-04-01 2006-09-20 Robert Michael Lipman Control apparatus
JP4871868B2 (en) * 2004-07-30 2012-02-08 バイオヴィジラント システムズ インコーポレイテッド Pathogen and particulate detection system and detection method
US9494581B2 (en) 2004-08-24 2016-11-15 University Of Wyoming System and method for Raman spectroscopy assay using paramagnetic particles
ITMI20041800A1 (en) * 2004-09-21 2004-12-21 Univ Degli Studi Milano NETWORK OF MEASUREMENT OF MOLECULAR INTERACTIONS WITH LLS
US8084260B2 (en) * 2004-11-24 2011-12-27 Applied Biosystems, Llc Spectral calibration method and system for multiple instruments
US9964469B2 (en) * 2005-02-28 2018-05-08 Imagion Biosystems, Inc. Magnetic needle separation and optical monitoring
US7818350B2 (en) 2005-02-28 2010-10-19 Yahoo! Inc. System and method for creating a collaborative playlist
MX2007014016A (en) * 2005-05-13 2008-02-11 Tripath Imaging Inc Methods of chromogen separation-based image analysis.
JP5112312B2 (en) * 2005-07-15 2013-01-09 バイオヴィジラント システムズ インコーポレイテッド Pathogen and particulate detection system and detection method
JP4810304B2 (en) * 2006-05-12 2011-11-09 キヤノン株式会社 Chemical sensor element and manufacturing method thereof
FR2901883B1 (en) * 2006-05-30 2008-09-19 Commissariat Energie Atomique DEVICE AND METHOD FOR MEASURING CHARACTERIZATION BY REFLECTOMETRY
US9133504B2 (en) * 2006-06-05 2015-09-15 California Institute Of Technology Real time microarrays
US8637436B2 (en) 2006-08-24 2014-01-28 California Institute Of Technology Integrated semiconductor bioarray
US11001881B2 (en) 2006-08-24 2021-05-11 California Institute Of Technology Methods for detecting analytes
US11525156B2 (en) 2006-07-28 2022-12-13 California Institute Of Technology Multiplex Q-PCR arrays
WO2008014485A2 (en) 2006-07-28 2008-01-31 California Institute Of Technology Multiplex q-pcr arrays
US11560588B2 (en) 2006-08-24 2023-01-24 California Institute Of Technology Multiplex Q-PCR arrays
US8207509B2 (en) * 2006-09-01 2012-06-26 Pacific Biosciences Of California, Inc. Substrates, systems and methods for analyzing materials
US7384798B2 (en) * 2006-10-31 2008-06-10 Hewlett-Packard Development Company, L.P. Method of detecting analytes in a microfluidic sample and a system for performing the same
US20080138842A1 (en) * 2006-12-11 2008-06-12 Hans Boehringer Indirect lateral flow sandwich assay
US20080231835A1 (en) * 2007-03-23 2008-09-25 Keigo Iizuka Divergence ratio distance mapping camera
ES2687620T3 (en) 2007-05-04 2018-10-26 Opko Diagnostics, Llc Device and method for analysis in microfluidic systems
CA2689626C (en) * 2007-06-06 2016-10-25 Pacific Biosciences Of California, Inc. Methods and processes for calling bases in sequence by incorporation methods
US8703422B2 (en) 2007-06-06 2014-04-22 Pacific Biosciences Of California, Inc. Methods and processes for calling bases in sequence by incorporation methods
JP5078458B2 (en) * 2007-06-22 2012-11-21 キヤノン株式会社 Imaging apparatus, control method therefor, and imaging system
US8339608B2 (en) * 2007-11-05 2012-12-25 Koninklijke Philips Electronics N.V. Method for detecting redispersion of beads
CA2741911A1 (en) * 2007-11-09 2009-05-14 The Royal Institution For The Advancement Of Learning/Mcgill University Quantification of an absorber through a scattering medium
US8628976B2 (en) * 2007-12-03 2014-01-14 Azbil BioVigilant, Inc. Method for the detection of biologic particle contamination
WO2009076323A2 (en) 2007-12-06 2009-06-18 Genalyte Inc. Monitoring enzymatic process
JP2009150829A (en) 2007-12-21 2009-07-09 Olympus Corp Biological sample observation method
CN101932929B (en) * 2008-01-31 2013-01-30 宝洁公司 Method for assessment of electrostatic properties of fibers or hair
AU2009292629B2 (en) 2008-09-16 2014-03-20 Pacific Biosciences Of California, Inc. Substrates and optical systems and methods of use thereof
JP5301232B2 (en) * 2008-09-30 2013-09-25 シスメックス株式会社 Blood cell image display device, sample analysis system, blood cell image display method, and computer program
JP2012507008A (en) 2008-10-24 2012-03-22 ユニヴァーシティー オブ ノートル ダム デュ ラック Method and apparatus for obtaining information on suspended particles
WO2010062627A2 (en) 2008-10-27 2010-06-03 Genalyte Inc. Biosensors based on optical probing and sensing
US8842900B2 (en) * 2008-10-28 2014-09-23 Sysmex Corporation Specimen processing system and blood cell image classifying apparatus
EP2356465B1 (en) 2008-11-13 2014-10-01 Beckman Coulter, Inc. Method of correction of particle interference to hemoglobin measurement
US20110235037A1 (en) * 2008-12-02 2011-09-29 Koninklijke Philips Electronics N.V. Sensor device for detecting target particles by frustrated total internal reflection
JP5079675B2 (en) * 2008-12-08 2012-11-21 日立マクセル株式会社 Biometric information acquisition device, biometric authentication device, light guide, and image acquisition device
EP2391451B1 (en) * 2009-02-02 2018-09-12 Opko Diagnostics, LLC Structures for controlling light interaction with microfluidic devices
US9778188B2 (en) 2009-03-11 2017-10-03 Industrial Technology Research Institute Apparatus and method for detection and discrimination molecular object
WO2010111086A1 (en) * 2009-03-26 2010-09-30 Becton, Dickinson And Company Assay cassette and system
JP5272965B2 (en) * 2009-08-19 2013-08-28 株式会社島津製作所 Fluorescence detector
JP5506443B2 (en) * 2010-02-10 2014-05-28 オリンパス株式会社 Fluorescence observation equipment
EP2536818B1 (en) * 2010-02-18 2018-10-03 Bima Limited Immobilised-bead immunomultiplex assay
EP2542869B1 (en) * 2010-03-03 2022-01-12 Battelle Memorial Institute Method of locating and removing spike noise from spectral data
US9482615B2 (en) 2010-03-15 2016-11-01 Industrial Technology Research Institute Single-molecule detection system and methods
US8410454B2 (en) 2010-05-12 2013-04-02 Li-Cor, Inc. High dynamic range scanning with reduced channel cross-talk
US8865078B2 (en) 2010-06-11 2014-10-21 Industrial Technology Research Institute Apparatus for single-molecule detection
US8865077B2 (en) 2010-06-11 2014-10-21 Industrial Technology Research Institute Apparatus for single-molecule detection
DE102010024964B4 (en) * 2010-06-24 2012-01-26 Siemens Aktiengesellschaft Cell monitoring by means of scattered light measurement
US8665286B2 (en) * 2010-08-12 2014-03-04 Telefonaktiebolaget Lm Ericsson (Publ) Composition of digital images for perceptibility thereof
EP3266881B1 (en) 2010-11-05 2019-12-25 Genalyte, Inc. Optical analyte detection systems and methods of use
US20130342684A1 (en) * 2011-01-19 2013-12-26 Teknologian Tutkimuskeskus Vtt Method and System for Determining Particle Size Information
EP2695105A4 (en) * 2011-04-04 2014-10-15 Aushon Biosystems Method of and system for enhanced dynamic range assay analysis
US9068945B2 (en) 2011-06-17 2015-06-30 Konica Minolta, Inc. Surface plasmon-field enhanced fluorescence spectroscopic measurement method and surface plasmon-field enhanced fluorescence spectroscopic measurement device
DE102011055367B4 (en) * 2011-11-15 2017-02-09 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Method and device for tracking a movement of a particle, in particular a single molecule, in a sample
US9291562B2 (en) 2011-11-15 2016-03-22 Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V. Method and apparatus for tracking a particle, particularly a single molecule, in a sample
WO2013084678A1 (en) * 2011-12-07 2013-06-13 独立行政法人科学技術振興機構 Optical system and method for determining presence or absence of viral particles using same
US9568416B2 (en) 2011-12-22 2017-02-14 General Electric Company Multimode systems and methods for detecting a sample
TWI638277B (en) 2012-03-05 2018-10-11 Ｏｐｋｏ診斷法有限責任公司 Assy system and method for determining a probability of an event associated with prostate cancer
TWI495850B (en) * 2012-03-07 2015-08-11 Kye Systems Corp Optical sensing device
EP3907506A1 (en) * 2012-03-12 2021-11-10 The Board of Trustees of the University of Illinois Optical analyte detection systems with magnetic enhancement and methods of their use
US10132736B2 (en) * 2012-05-24 2018-11-20 Abbvie Inc. Methods for inspection of protein particles in a liquid beneficial agent
US20140092116A1 (en) * 2012-06-18 2014-04-03 Uti Limited Partnership Wide dynamic range display
BR112014032911A2 (en) * 2012-06-28 2017-06-27 Fluoresentric Inc chemical indicating device
US9912847B1 (en) 2012-09-25 2018-03-06 Amazon Technologies, Inc. Image capture guidance to reduce specular reflection effects
WO2014120158A1 (en) * 2013-01-30 2014-08-07 Hewlett-Packard Development Company, L.P. Polarization selective surface enhanced raman spectroscopy
US9983206B2 (en) 2013-03-15 2018-05-29 The Board Of Trustees Of The University Of Illinois Methods and compositions for enhancing immunoassays
WO2015000720A1 (en) * 2013-07-01 2015-01-08 Koninklijke Philips N.V. System for determining a quantitative number being indicative of the concentration of target elements in a fluid
US9976039B1 (en) * 2013-10-04 2018-05-22 Hrl Laboratories, Llc Surface-structured coatings
US9774804B2 (en) 2013-12-13 2017-09-26 Bio-Rad Laboratories, Inc. Digital imaging with masked pixels
US9736388B2 (en) * 2013-12-13 2017-08-15 Bio-Rad Laboratories, Inc. Non-destructive read operations with dynamically growing images
US9377214B2 (en) * 2014-01-21 2016-06-28 Mpi Corporation Heating device using photodetector to detect temperature and method for protecting the same
US11423169B1 (en) 2014-04-14 2022-08-23 Goknown Llc System, method and apparatus for securely storing data on public networks
US9830467B1 (en) * 2014-04-14 2017-11-28 Michael Harold System, method and apparatus for securely storing data on public networks
US10460188B2 (en) * 2014-08-26 2019-10-29 Gingy Technology Inc. Bio-sensing apparatus
CN107209102B (en) * 2015-02-18 2021-03-02 贝克顿·迪金森公司 Optical detection system and method of use
US10908062B2 (en) * 2015-03-06 2021-02-02 Scanit Technologies, Inc. Airborne particle monitor
US9708647B2 (en) 2015-03-23 2017-07-18 Insilixa, Inc. Multiplexed analysis of nucleic acid hybridization thermodynamics using integrated arrays
JP6470604B2 (en) * 2015-03-25 2019-02-13 キヤノン株式会社 Image processing apparatus, image processing method, and program
US9499861B1 (en) 2015-09-10 2016-11-22 Insilixa, Inc. Methods and systems for multiplex quantitative nucleic acid amplification
JP6676066B2 (en) 2015-11-05 2020-04-08 ギガフォトン株式会社 Extreme ultraviolet light generator
US20170160187A1 (en) * 2015-12-08 2017-06-08 Tdk Corporation Laser Scanner Particle Counter and Imager
US10816538B2 (en) 2016-01-28 2020-10-27 Siemens Healthcare Diagnostics Inc. Methods and apparatus for detecting an interferent in a specimen
WO2017155858A1 (en) 2016-03-07 2017-09-14 Insilixa, Inc. Nucleic acid sequence identification using solid-phase cyclic single base extension
JP6402838B2 (en) * 2016-03-25 2018-10-10 大日本印刷株式会社 Electromagnetic wave responsive laminate
DE102016107900B4 (en) * 2016-04-28 2020-10-08 Carl Zeiss Industrielle Messtechnik Gmbh Method and device for determining the edge of a measurement object in optical measurement technology
WO2017200939A1 (en) * 2016-05-16 2017-11-23 Abbvie Inc. Systems and methods for identifying protein aggregates in biotherapeutics
US10132958B2 (en) * 2016-07-14 2018-11-20 Schlumberger Technology Corporation Determining an optical density linear dynamic range for an optical spectrometer
US10416511B2 (en) * 2016-08-31 2019-09-17 Panasonic Liquid Crystal Display Co., Ltd. Liquid crystal display device
WO2018092573A1 (en) * 2016-11-16 2018-05-24 株式会社堀場製作所 Particle diameter distribution measuring device, particle diameter distribution measuring method, and program for particle diameter distribution measuring device
US10324041B2 (en) 2016-12-21 2019-06-18 Abbott Japan Co., Ltd. Optical imaging system using lateral illumination for digital assays
US11428690B2 (en) * 2017-01-30 2022-08-30 University Of Miami Portable plasmonic system for disease detection
US11047854B2 (en) 2017-02-06 2021-06-29 Abbott Japan Llc Methods for reducing noise in signal-generating digital assays
JP6467579B2 (en) * 2017-04-07 2019-02-13 トライボテックス株式会社 Particle counting apparatus and particle counting method
CA3064358A1 (en) 2017-05-22 2018-11-29 La Trobe University Image contrast enhancement for optical microscopy
EP3422288B1 (en) * 2017-06-26 2020-02-26 Tecan Trading Ag Imaging a well of a microplate
US11156960B2 (en) * 2017-08-08 2021-10-26 California Institute Of Technology Focusing light inside scattering media with magnetic particle guided wavefront shaping
US11041756B2 (en) * 2017-10-20 2021-06-22 Charted Scientific Inc. Method and apparatus of filtering light using a spectrometer enhanced with additional spectral filters with optical analysis of fluorescence and scattered light from particles suspended in a liquid medium using confocal and non confocal illumination and imaging
US10497104B2 (en) * 2017-10-24 2019-12-03 Adobe Inc. Empirical exposure normalization
US11561221B2 (en) * 2018-05-02 2023-01-24 Trustees Of Boston University Dynamic tracking of captured targets for enhanced digital biosensing
US10545096B1 (en) 2018-10-11 2020-01-28 Nanotronics Imaging, Inc. Marco inspection systems, apparatus and methods
JP2022510203A (en) * 2018-11-29 2022-01-26 ラ トローブ ユニバーシティ Automation method to identify the structure
JP2022525322A (en) 2019-03-14 2022-05-12 インシリクサ， インコーポレイテッド Methods and systems for time-gate fluorescence-based detection
JP2022535798A (en) * 2019-05-31 2022-08-10 シトノス、ソシエダッド、リミターダ Hyperspectral quantitative imaging cytometry system
JP7217677B2 (en) * 2019-07-16 2023-02-03 株式会社日立製作所 Sample measuring device and sample measuring method
US10915992B1 (en) 2019-08-07 2021-02-09 Nanotronics Imaging, Inc. System, method and apparatus for macroscopic inspection of reflective specimens
US11593919B2 (en) 2019-08-07 2023-02-28 Nanotronics Imaging, Inc. System, method and apparatus for macroscopic inspection of reflective specimens
CA3062471A1 (en) * 2019-11-21 2021-05-21 Photon Etc. Inc. Infrared imaging system and related method
WO2021118982A1 (en) * 2019-12-10 2021-06-17 Trustees Of Boston University Apparatus and method for biomolecular analysis
WO2021202791A1 (en) * 2020-03-31 2021-10-07 Logicink Corporation System for detection of a target analyte via self-testing, object surfaces, and the environment
BR112022023418A2 (en) 2020-05-20 2023-03-21 Ysi Inc EXTENDED SOLID ANGLE TURBIDITY SENSOR
US20220236165A1 (en) * 2021-01-27 2022-07-28 Becton, Dickinson And Company Flow cytometers including fiber optic light collectors, and methods of use thereof
CN113433149B (en) * 2021-05-26 2022-10-11 中国科学院金属研究所 Method for realizing cross-scale continuous automatic characterization analysis and test of EBSD (electronic brake force sensor) system

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5266498A (en) * 1989-10-27 1993-11-30 Abbott Laboratories Ligand binding assay for an analyte using surface-enhanced scattering (SERS) signal
US5986808A (en) * 1996-10-11 1999-11-16 California Institute Of Technology Surface-plasmon-wave-coupled tunable filter
US6171793B1 (en) * 1999-04-19 2001-01-09 Affymetrix, Inc. Method for scanning gene probe array to produce data having dynamic range that exceeds that of scanner
US6180415B1 (en) * 1997-02-20 2001-01-30 The Regents Of The University Of California Plasmon resonant particles, methods and apparatus

Family Cites Families (109)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3790760A (en) * 1971-09-27 1974-02-05 Cornell Aeronautical Labor Inc Apparatus for counting, differentiating and sorting particles according to their microstructure variations
US3975084A (en) * 1973-09-27 1976-08-17 Block Engineering, Inc. Particle detecting system
US3939350A (en) * 1974-04-29 1976-02-17 Board Of Trustees Of The Leland Stanford Junior University Fluorescent immunoassay employing total reflection for activation
US4157498A (en) 1977-08-01 1979-06-05 Miles Laboratories, Inc. Flow-through type particle analyzing apparatus
US4231750A (en) * 1977-12-13 1980-11-04 Diagnostic Reagents, Inc. Methods for performing chemical assays using fluorescence and photon counting
NL7807532A (en) * 1978-07-13 1980-01-15 Akzo Nv METAL IMMUNO TEST.
US4245031A (en) * 1979-09-18 1981-01-13 E. I. Du Pont De Nemours And Company Photopolymerizable compositions based on salt-forming polymers and polyhydroxy polyethers
US4420558A (en) * 1981-02-12 1983-12-13 Janssen Pharmaceutica N.V. Bright field light microscopic method of enumerating and characterizing subtypes of white blood cells and their precursors
GB2095258B (en) 1981-03-19 1984-09-05 Janssen Pharmaceutica Nv A bright field light microscopic method of localizing tissue antigens
US4480042A (en) * 1981-10-28 1984-10-30 E. I. Du Pont De Nemours And Company Covalently bonded high refractive index particle reagents and their use in light scattering immunoassays
US4597944A (en) * 1983-10-18 1986-07-01 Cottingham Hugh V Agglutination reagent detection system
JPS60149130A (en) * 1984-01-17 1985-08-06 Hitachi Ltd Method for pattern detection
US4624923A (en) 1984-06-08 1986-11-25 Yeda Research And Development Company Limited Metal-coated polyaldehyde microspheres
US4752567A (en) 1984-06-21 1988-06-21 Janssen Pharmaceutica N.V. Method of visualizing individual submicroscopic metal particles
US4647544A (en) * 1984-06-25 1987-03-03 Nicoli David F Immunoassay using optical interference detection
US4983834A (en) 1985-10-10 1991-01-08 Quantex Corporation Large area particle detector system
US5501949A (en) 1985-12-10 1996-03-26 Murex Diagnostics Corporation Particle bound binding component immunoassay
CA1291031C (en) * 1985-12-23 1991-10-22 Nikolaas C.J. De Jaeger Method for the detection of specific binding agents and their correspondingbindable substances
US5137827A (en) 1986-03-25 1992-08-11 Midwest Research Technologies, Inc. Diagnostic element for electrical detection of a binding reaction
US4877647A (en) 1986-04-17 1989-10-31 Kansas State University Research Foundation Method of coating substrates with solvated clusters of metal particles
US4929400A (en) 1986-04-28 1990-05-29 California Institute Of Technology Production of monodisperse, polymeric microspheres
US4851329A (en) * 1986-06-06 1989-07-25 Massachusetts Institute Of Technology Immunoassay employing optical pulse particle size analysis
US5514602A (en) * 1986-06-09 1996-05-07 Ortho Diagnostic Systems, Inc. Method of producing a metal sol reagent containing colloidal metal particles
US5017009A (en) 1986-06-26 1991-05-21 Ortho Diagnostic Systems, Inc. Scattered total internal reflectance immunoassay system
GB8623072D0 (en) 1986-09-25 1986-10-29 Amersham Int Plc Particle analysis
US5015580A (en) 1987-07-29 1991-05-14 Agracetus Particle-mediated transformation of soybean plants and lines
US4876208A (en) 1987-01-30 1989-10-24 Yellowstone Diagnostics Corporation Diffraction immunoassay apparatus and method
DE3789547T2 (en) * 1987-02-13 1994-07-14 Toray Industries Anti-reflective optical object and process for its production.
US5202231A (en) * 1987-04-01 1993-04-13 Drmanac Radoje T Method of sequencing of genomes by hybridization of oligonucleotide probes
US5110727A (en) 1987-04-03 1992-05-05 Cardiovascular Diagnostics, Inc. Method for performing coagulation assays accurately, rapidly and simply, using dry chemical reagents and paramagnetic particles
US4806583A (en) * 1987-06-19 1989-02-21 Battaglia Charles R Antiglare coating
GB8803000D0 (en) * 1988-02-10 1988-03-09 Ekins Roger Philip Determination of ambient concentrations of several analytes
NO164622C (en) 1988-05-11 1990-10-24 Tore Lindmo BINAER IMMUNOMETRIC PARTICLE-BASED METHOD FOR MEASURING SPECIFIC SERUM ANTIGENS USING LIQUID FLOW MICROPHOTOMETRY AND A PREPARED TARGET SET UP THEREOF.
DE3826055A1 (en) * 1988-07-30 1990-02-01 Boehringer Mannheim Gmbh REAGENT-RELEASED TRAEGERMATRIX WITH REAGENT
US5079172A (en) * 1988-11-04 1992-01-07 Board Of Trustees Operating Michigan State University Method for detecting the presence of antibodies using gold-labeled antibodies and test kit
US5100805A (en) * 1989-01-26 1992-03-31 Seradyn, Inc. Quantitative immunoassay system and method for agglutination assays
US5338353A (en) 1989-04-07 1994-08-16 Nippon Shokubai Kagaku Kogyo Method for production of powder of fine inorganic particles
US6309822B1 (en) 1989-06-07 2001-10-30 Affymetrix, Inc. Method for comparing copy number of nucleic acid sequences
US5145748A (en) * 1989-06-20 1992-09-08 W.R. Grace & Co. -Conn. Waterproofing system for water-penetrable construction surfaces
CA2070389A1 (en) 1989-10-18 1991-04-19 Ramesh C. Patel Coated particles and methods of coating particles
US5376556A (en) 1989-10-27 1994-12-27 Abbott Laboratories Surface-enhanced Raman spectroscopy immunoassay
US5120135A (en) 1989-12-13 1992-06-09 Syntex (U.S.A.) Inc. Method and apparatus for keeping particles in suspension
JP2899360B2 (en) * 1990-05-21 1999-06-02 興和株式会社 Method and apparatus for measuring particles in fluid
US5350697A (en) 1990-08-28 1994-09-27 Akzo N.V. Scattered light detection apparatus
US5294369A (en) * 1990-12-05 1994-03-15 Akzo N.V. Ligand gold bonding
US5784162A (en) * 1993-08-18 1998-07-21 Applied Spectral Imaging Ltd. Spectral bio-imaging methods for biological research, medical diagnostics and therapy
JP3115641B2 (en) * 1991-04-24 2000-12-11 シスメックス株式会社 Particle counting method
US5286452A (en) * 1991-05-20 1994-02-15 Sienna Biotech, Inc. Simultaneous multiple assays
EP0596883A4 (en) * 1991-07-26 1994-12-07 Cirrus Diagnostics Inc Automated immunoassay analyzer.
JP2523227Y2 (en) * 1991-07-30 1997-01-22 株式会社堀場製作所 Foreign matter inspection device
US5516670A (en) 1991-09-30 1996-05-14 Kuehnle; Adelheid R. Magnetophoretic particle delivery method and apparatus for the treatment of cells
US5151956A (en) 1991-12-20 1992-09-29 The United Staes Of America As Represented By The Secretary Of The Army Waveguide polarizer using localized surface plasmons
US5248772A (en) * 1992-01-29 1993-09-28 Coulter Corporation Formation of colloidal metal dispersions using aminodextrans as reductants and protective agents
US5471674A (en) * 1992-02-07 1995-11-28 Dell Usa, L.P. Computer system with plug-in override of system ROM
US5305073A (en) * 1992-02-12 1994-04-19 Precision Detectors, Inc. Methods and apparatus for molecular characterization
US5451525A (en) 1992-02-14 1995-09-19 Coulter Corporation Method and materials for determining particle count in a flow cytometer
US5518887A (en) 1992-03-30 1996-05-21 Abbott Laboratories Immunoassays empolying generic anti-hapten antibodies and materials for use therein
US5231434A (en) * 1992-03-31 1993-07-27 Minnesota Mining And Manufacturing Company Overhead projector for LCD panel
US5329461A (en) * 1992-07-23 1994-07-12 Acrogen, Inc. Digital analyte detection system
US5357320A (en) 1992-09-04 1994-10-18 Canon Kabushiki Kaisha Electrophotographic apparatus
DE4404128A1 (en) * 1993-02-19 1994-08-25 Gao Ges Automation Org Security document and method for its manufacture
US5350922A (en) * 1993-03-22 1994-09-27 Robert Bartz Underwater light scattering sensor
US5350911A (en) * 1993-04-09 1994-09-27 Hughes Aircraft Company Wavefront error estimation derived from observation of arbitrary unknown extended scenes
US5530922A (en) * 1993-11-09 1996-06-25 Motorola, Inc. Power detector with matching impedance for radio frequency signal amplifiers
US6530922B2 (en) * 1993-12-15 2003-03-11 Sherwood Services Ag Cluster ablation electrode system
US5576827A (en) * 1994-04-15 1996-11-19 Micromeritics Instrument Corporation Apparatus and method for determining the size distribution of particles by light scattering
DE4414166C1 (en) * 1994-04-22 1995-12-07 Lorenz Mesgeraetebau Method and device for measuring light scattering on particles
US5734498A (en) * 1994-05-09 1998-03-31 The Regents Of The University Of California Illuminator elements for conventional light microscopes
US5807522A (en) 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US5728590A (en) 1994-07-29 1998-03-17 Nanoprobes, Inc. Small organometallic probes
US5498875A (en) * 1994-08-17 1996-03-12 Beckman Instruments, Inc. Signal processing for chemical analysis of samples
US5576627A (en) * 1994-09-06 1996-11-19 The Regents Of The University Of California Narrow field electromagnetic sensor system and method
US5599668A (en) 1994-09-22 1997-02-04 Abbott Laboratories Light scattering optical waveguide method for detecting specific binding events
US6014213A (en) * 1994-12-12 2000-01-11 Visible Genetics Inc. High dynamic range apparatus for separation and detection of polynucleotide fragments
US5786142A (en) * 1995-05-30 1998-07-28 Visible Genetics Inc. Electrophoresis and fluorescence detection method
US6159748A (en) * 1995-03-13 2000-12-12 Affinitech, Ltd Evaluation of autoimmune diseases using a multiple parameter latex bead suspension and flow cytometry
JP3284056B2 (en) * 1995-09-12 2002-05-20 株式会社東芝 Substrate processing apparatus and pattern forming method
AU7598996A (en) * 1995-10-25 1997-05-15 University Of Washington Surface plasmon resonance probe systems based on a folded planar lightpipe
US5851777A (en) * 1996-02-05 1998-12-22 Dade Behring Inc. Homogeneous sol-sol assay
US6586193B2 (en) * 1996-04-25 2003-07-01 Genicon Sciences Corporation Analyte assay using particulate labels
ATE357663T1 (en) 1996-04-25 2007-04-15 Genicon Sciences Corp ANALYTICAL TASSAY USING PARTICLE MARKER
US5856018A (en) * 1996-06-17 1999-01-05 Yazaki Corporation Plastic articles having multi-layer antireflection coatings, and sol-gel process for depositing such coatings
CN1230216A (en) * 1996-07-08 1999-09-29 伯斯坦恩实验室股份有限公司 Cleavable signal element device and method
US6165798A (en) * 1996-10-10 2000-12-26 University Of British Columbia Optical quantification of analytes in membranes
US20020034737A1 (en) * 1997-03-04 2002-03-21 Hyseq, Inc. Methods and compositions for detection or quantification of nucleic acid species
JPH10206603A (en) * 1997-01-20 1998-08-07 Dainippon Printing Co Ltd Reflection preventive film and manufacture thereof
US6122042A (en) * 1997-02-07 2000-09-19 Wunderman; Irwin Devices and methods for optically identifying characteristics of material objects
JP3487117B2 (en) * 1997-02-28 2004-01-13 松下電工株式会社 Data processing device
US6974669B2 (en) 2000-03-28 2005-12-13 Nanosphere, Inc. Bio-barcodes based on oligonucleotide-modified nanoparticles
US6294327B1 (en) * 1997-09-08 2001-09-25 Affymetrix, Inc. Apparatus and method for detecting samples labeled with material having strong light scattering properties, using reflection mode light and diffuse scattering
US6982431B2 (en) * 1998-08-31 2006-01-03 Molecular Devices Corporation Sample analysis systems
US6326605B1 (en) * 1998-02-20 2001-12-04 Ljl Biosystems, Inc. Broad range light detection system
JP3507319B2 (en) * 1997-12-08 2004-03-15 キヤノン株式会社 Optical property measurement device
US6087102A (en) * 1998-01-07 2000-07-11 Clontech Laboratories, Inc. Polymeric arrays and methods for their use in binding assays
AUPP155998A0 (en) 1998-01-29 1998-02-19 Sola International Holdings Ltd Coating composition
JPH11249886A (en) * 1998-02-27 1999-09-17 Matsushita Electric Ind Co Ltd Electronic equipment
EP1141762A1 (en) 1998-12-17 2001-10-10 Leica Microsystems Heidelberg GmbH Method for differentiated investigation of diverse structures in preferably biological preparations
US6528323B1 (en) * 1999-06-14 2003-03-04 Praxsys Biosystems, Inc. Bidirectional lateral flow test strip and method
KR20010108656A (en) * 2000-05-30 2001-12-08 윤종용 Method of programing flash memory
US7301199B2 (en) 2000-08-22 2007-11-27 President And Fellows Of Harvard College Nanoscale wires and related devices
AU2002245537B2 (en) 2001-02-23 2007-12-20 Genicon Sciences Corporation Methods for providing extended dynamic range in analyte assays
US6775427B2 (en) 2001-03-09 2004-08-10 Photodigm, Inc. Laterally coupled wave guides
US20030049866A1 (en) 2001-09-05 2003-03-13 Genicon Sciences Corporation Sample device preservation
US7150910B2 (en) 2001-11-16 2006-12-19 Massachusetts Institute Of Technology Nanocrystal structures
US7352468B2 (en) 2001-12-12 2008-04-01 Trustees Of Princeton University Cavity ring-down detection of surface plasmon resonance in an optical fiber resonator
US6985664B2 (en) 2003-08-01 2006-01-10 Corning Incorporated Substrate index modification for increasing the sensitivity of grating-coupled waveguides
US20080076119A9 (en) 2003-12-29 2008-03-27 Lei Sun Composite organic inorganic nanoclusters
JP5005164B2 (en) 2004-03-03 2012-08-22 株式会社ジャパンディスプレイイースト LIGHT EMITTING ELEMENT, LIGHT EMITTING DISPLAY DEVICE AND LIGHTING DEVICE
US7796266B2 (en) 2004-04-30 2010-09-14 Kimberly-Clark Worldwide, Inc. Optical detection system using electromagnetic radiation to detect presence or quantity of analyte

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5266498A (en) * 1989-10-27 1993-11-30 Abbott Laboratories Ligand binding assay for an analyte using surface-enhanced scattering (SERS) signal
US5986808A (en) * 1996-10-11 1999-11-16 California Institute Of Technology Surface-plasmon-wave-coupled tunable filter
US6180415B1 (en) * 1997-02-20 2001-01-30 The Regents Of The University Of California Plasmon resonant particles, methods and apparatus
US6171793B1 (en) * 1999-04-19 2001-01-09 Affymetrix, Inc. Method for scanning gene probe array to produce data having dynamic range that exceeds that of scanner

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1488208A4 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8918161B2 (en) 1999-10-06 2014-12-23 Becton, Dickinson And Company Methods of use for surface enhanced spectroscopy-active composite nanoparticles
US9201013B2 (en) 1999-10-06 2015-12-01 Becton, Dickinson And Company Method for tagging material with surface-enhanced spectroscopy (SES)-active composite nanoparticles
US9297766B2 (en) 2001-01-26 2016-03-29 Becton, Dickinson And Company Method of tagging materials with surface-enhanced spectroscopy-active sandwich particles

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