WO2002069902A3 - Cyclosporins for the treatment of respiratory diseases - Google Patents
Cyclosporins for the treatment of respiratory diseases Download PDFInfo
- Publication number
- WO2002069902A3 WO2002069902A3 PCT/US2002/006541 US0206541W WO02069902A3 WO 2002069902 A3 WO2002069902 A3 WO 2002069902A3 US 0206541 W US0206541 W US 0206541W WO 02069902 A3 WO02069902 A3 WO 02069902A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- halogen
- ser
- alkylthio
- alkoxy
- alkyl
- Prior art date
Links
- 108010036941 Cyclosporins Proteins 0.000 title 1
- 229930182912 cyclosporin Natural products 0.000 title 1
- 208000023504 respiratory system disease Diseases 0.000 title 1
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical class CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02713733A EP1365791A2 (en) | 2001-03-05 | 2002-03-05 | Cyclosporins for the treatment of respiratory diseases |
JP2002569080A JP2004526719A (en) | 2001-03-05 | 2002-03-05 | Cyclosporine for the treatment of respiratory diseases |
CA002439832A CA2439832A1 (en) | 2001-03-05 | 2002-03-05 | Cyclosporins for the treatment of respiratory diseases |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/800,856 US6784156B2 (en) | 2001-03-05 | 2001-03-05 | Cyclosporins for the treatment of respiratory diseases |
US09/800,856 | 2001-03-05 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2002069902A2 WO2002069902A2 (en) | 2002-09-12 |
WO2002069902A3 true WO2002069902A3 (en) | 2003-04-17 |
Family
ID=25179553
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2002/006541 WO2002069902A2 (en) | 2001-03-05 | 2002-03-05 | Cyclosporins for the treatment of respiratory diseases |
Country Status (5)
Country | Link |
---|---|
US (3) | US6784156B2 (en) |
EP (1) | EP1365791A2 (en) |
JP (1) | JP2004526719A (en) |
CA (1) | CA2439832A1 (en) |
WO (1) | WO2002069902A2 (en) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030087813A1 (en) * | 2001-10-12 | 2003-05-08 | Or Yat Sun | Cyclosporin analogs for the treatment of lung diseases |
WO2004042081A1 (en) * | 2002-11-04 | 2004-05-21 | Charité-Universitätsme Dizin Berlin | Specific haplotypes of the mdr1 gene and their use in diagnosis and therapy |
US20040110666A1 (en) * | 2002-12-04 | 2004-06-10 | Or Yat Sun | Cyclosporins for the treatment of immune disorders |
US7012065B2 (en) | 2003-02-07 | 2006-03-14 | Enanta Pharmaceuticals, Inc. | Cyclosporins for the treatment of immune disorders |
US20040261140A1 (en) * | 2003-03-07 | 2004-12-23 | Benson John D. | Transgenic mice expressing human formyl peptide receptor |
US7538084B2 (en) * | 2003-03-17 | 2009-05-26 | Amr Technology, Inc. | Cyclosporins |
US20050059583A1 (en) | 2003-09-15 | 2005-03-17 | Allergan, Inc. | Methods of providing therapeutic effects using cyclosporin components |
US20060014677A1 (en) * | 2004-07-19 | 2006-01-19 | Isotechnika International Inc. | Method for maximizing efficacy and predicting and minimizing toxicity of calcineurin inhibitor compounds |
US7226906B2 (en) * | 2004-08-16 | 2007-06-05 | Array Biopharma, Inc. | Cyclosporin analogs for the treatment of immunoregulatory disorders and respiratory diseases |
US20060035821A1 (en) * | 2004-08-16 | 2006-02-16 | Hunt Kevin W | Cyclosporin analogs for the treatment of immunoregulatory disorders and respiratory diseases |
JP2008514701A (en) * | 2004-09-29 | 2008-05-08 | エーエムアール テクノロジー インコーポレイテッド | Cyclosporine alkyne analogs and their pharmaceutical use |
US7511013B2 (en) * | 2004-09-29 | 2009-03-31 | Amr Technology, Inc. | Cyclosporin analogues and their pharmaceutical uses |
WO2006041631A2 (en) * | 2004-10-06 | 2006-04-20 | Amr Technology, Inc. | Novel cyclosporin alkynes and their utility as pharmaceutical agents |
US7151085B2 (en) * | 2004-11-15 | 2006-12-19 | Allergan, Inc. | Therapeutic methods using cyclosporine components |
US7135455B2 (en) * | 2004-11-15 | 2006-11-14 | Allergan, Inc | Methods for the therapeutic use of cyclosporine components |
KR20070100284A (en) * | 2004-12-17 | 2007-10-10 | 이소테크니카 인코포레이티드 | Metabolites of cyclosporin analogs |
TW200711649A (en) * | 2005-06-17 | 2007-04-01 | Combinatorx Inc | Combination therapy for the treatment of immunoinflammatory disorders |
US7696165B2 (en) * | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders |
US7696166B2 (en) * | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders |
WO2009018424A2 (en) | 2007-08-01 | 2009-02-05 | Emory University | Methods for determination of protein phosphatase activity, and uses in predicting therapeutic outcomes |
JP5668476B2 (en) * | 2007-10-08 | 2015-02-12 | オーリニア・ファーマシューティカルズ・インコーポレイテッドAurinia Pharmaceuticals Inc. | Ophthalmic composition comprising a calcineurin inhibitor or mTOR inhibitor |
WO2010012073A1 (en) * | 2008-07-30 | 2010-02-04 | Isotechnika Labs Inc. | Nonimmunosuppressive cyclosporine analogue molecules |
BRPI1007476A2 (en) * | 2009-01-30 | 2016-02-16 | Enanta Pharm Inc | cyclosporine analogues to prevent or treat hepatitis C infection |
US8481483B2 (en) * | 2009-02-19 | 2013-07-09 | Enanta Pharmaceuticals, Inc. | Cyclosporin analogues |
CA2763893A1 (en) * | 2009-06-02 | 2010-12-09 | Nikan Pharmaceuticals, Llc | Antagonism of human formyl peptide receptor for treatment of disease |
ES2537385T3 (en) * | 2009-06-09 | 2015-06-08 | Aurinia Pharmaceuticals Inc. | Topical supply systems for ophthalmic use |
US8685917B2 (en) * | 2009-07-09 | 2014-04-01 | Enanta Pharmaceuticals, Inc. | Cyclosporin analogues |
US8367053B2 (en) * | 2009-07-09 | 2013-02-05 | Enanta Pharmaceuticals, Inc. | Cyclosporin analogues |
US8349312B2 (en) * | 2009-07-09 | 2013-01-08 | Enanta Pharmaceuticals, Inc. | Proline substituted cyclosporin analogues |
US8623814B2 (en) * | 2010-02-23 | 2014-01-07 | Enanta Pharmaceuticals, Inc. | Antiviral agents |
MX353720B (en) | 2010-12-15 | 2018-01-25 | Contravir Pharmaceuticals Inc | Cyclosporine analogue molecules modified at amino acid 1 and 3. |
WO2012145426A1 (en) | 2011-04-18 | 2012-10-26 | The Trustees Of Columbia University In The City Of New York | Methods to treat cancer using cyclosporine and cyclosporine derivatives |
DE102011111991A1 (en) * | 2011-08-30 | 2013-02-28 | Lead Discovery Center Gmbh | New cyclosporin derivatives |
WO2013181339A2 (en) | 2012-06-01 | 2013-12-05 | Allergan, Inc. | Cyclosporin a analogs |
WO2014085623A1 (en) | 2012-11-28 | 2014-06-05 | Enanta Pharmaceuticals, Inc. | Novel [n-me-4-hydroxyleucine]-9-cyclosporin analogues |
WO2014165308A2 (en) | 2013-04-01 | 2014-10-09 | Allergan, Inc. | Microsphere drug delivery system for sustained intraocular release |
CA2921961A1 (en) | 2013-08-26 | 2015-03-05 | Enanta Pharmaceuticals, Inc. | Cyclosporin analogues for preventing or treating hepatitis c |
US9669095B2 (en) | 2014-11-03 | 2017-06-06 | Enanta Pharmaceuticals, Inc. | Cyclosporin analogues for preventing or treating hepatitis C infection |
US9914755B2 (en) | 2015-01-08 | 2018-03-13 | Allergan, Inc. | Cyclosporin derivatives wherein the MeBmt sidechain has been cyclized |
US20190224275A1 (en) | 2017-05-12 | 2019-07-25 | Aurinia Pharmaceuticals Inc. | Protocol for treatment of lupus nephritis |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4554351A (en) * | 1980-02-14 | 1985-11-19 | Sandoz Ltd. | Method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production |
US4798823A (en) * | 1987-06-03 | 1989-01-17 | Merck & Co., Inc. | New cyclosporin analogs with modified "C-9 amino acids" |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US132763A (en) * | 1872-11-05 | Improvement in watchmakers lathes and chucks | ||
US5427960A (en) * | 1987-03-27 | 1995-06-27 | Abbott Laboratories | Fluorescence polarization assay for cyclosporin A and metabolites and related immunogens and antibodies |
US5239057A (en) * | 1987-03-27 | 1993-08-24 | Abbott Laboratories | Fluorescence polarization assay for cyclosporin a and metabolites and related immunogens and antibodies |
EP0296122B1 (en) | 1987-06-17 | 1993-09-29 | Sandoz Ag | Cyclosporins and their use as pharmaceuticals |
GB9204466D0 (en) | 1992-03-02 | 1992-04-15 | Sandoz Ltd | Improvements in or relating to organic compounds |
EP0578616A3 (en) * | 1992-07-09 | 1994-06-01 | Sandoz Ltd | Cylosporin synthetase |
EP0991660B8 (en) | 1997-10-08 | 2006-04-05 | Isotechnika,Inc. | DEUTERATED and undeuterated CYCLOSPORINE ANALOGS AND THEIR USE AS IMMUNOMODULATING AGENTS |
WO1999065933A1 (en) | 1998-06-12 | 1999-12-23 | C-Chem Ag | Novel cyclosporins |
-
2001
- 2001-03-05 US US09/800,856 patent/US6784156B2/en not_active Expired - Lifetime
-
2002
- 2002-03-05 JP JP2002569080A patent/JP2004526719A/en active Pending
- 2002-03-05 EP EP02713733A patent/EP1365791A2/en not_active Withdrawn
- 2002-03-05 CA CA002439832A patent/CA2439832A1/en not_active Abandoned
- 2002-03-05 WO PCT/US2002/006541 patent/WO2002069902A2/en active Application Filing
-
2003
- 2003-01-16 US US10/345,866 patent/US20030109426A1/en not_active Abandoned
- 2003-01-23 US US10/349,890 patent/US7012064B2/en not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4554351A (en) * | 1980-02-14 | 1985-11-19 | Sandoz Ltd. | Method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production |
US4798823A (en) * | 1987-06-03 | 1989-01-17 | Merck & Co., Inc. | New cyclosporin analogs with modified "C-9 amino acids" |
Also Published As
Publication number | Publication date |
---|---|
US20020142946A1 (en) | 2002-10-03 |
CA2439832A1 (en) | 2002-09-12 |
WO2002069902A2 (en) | 2002-09-12 |
US20030186855A1 (en) | 2003-10-02 |
US20030109426A1 (en) | 2003-06-12 |
EP1365791A2 (en) | 2003-12-03 |
US7012064B2 (en) | 2006-03-14 |
JP2004526719A (en) | 2004-09-02 |
US6784156B2 (en) | 2004-08-31 |
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