WO2002069906A3 - Compounds and methods for the treatment of urogenital disorders - Google Patents

Compounds and methods for the treatment of urogenital disorders Download PDF

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Publication number
WO2002069906A3
WO2002069906A3 PCT/US2002/007026 US0207026W WO02069906A3 WO 2002069906 A3 WO2002069906 A3 WO 2002069906A3 US 0207026 W US0207026 W US 0207026W WO 02069906 A3 WO02069906 A3 WO 02069906A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
activators
disorders
inhibitors
variety
Prior art date
Application number
PCT/US2002/007026
Other languages
French (fr)
Other versions
WO2002069906A2 (en
Inventor
Vivien H W Mak
Stephen Grayson
Original Assignee
Cellegy Pharma Inc
Vivien H W Mak
Stephen Grayson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cellegy Pharma Inc, Vivien H W Mak, Stephen Grayson filed Critical Cellegy Pharma Inc
Priority to IL15773402A priority Critical patent/IL157734A0/en
Priority to JP2002569084A priority patent/JP2005504721A/en
Priority to KR10-2003-7011650A priority patent/KR20040052489A/en
Priority to CA002440141A priority patent/CA2440141A1/en
Priority to MXPA03007960A priority patent/MXPA03007960A/en
Priority to EP02723359A priority patent/EP1383502A4/en
Publication of WO2002069906A2 publication Critical patent/WO2002069906A2/en
Publication of WO2002069906A3 publication Critical patent/WO2002069906A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • A61K38/446—Superoxide dismutase (1.15)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

The present invention provides methods for treating a variety of urogenital disorders, such as, for example, vaginismus, dyspareunia, vulvodynia (including vulvar vestibulitis), interstitial cystitis, nonspecific urethriris (i.e., nonspecific pain and/or burning of the urinary tract) and sexual dysfunctions, such as, for example, female sexual arousal disorders and female sexual orgasmic disorders, using a variety of compounds, including, but not limited to, NO donors, calcium channel blockers, cholinergic modulators, a-adrenergic receptor antagonists, b-adrenergic receptor agonists, phosphodiesterase inhibitors, cAMP-dependent protein kinase activators (e.g., cAMP mimetics), superoxide scavengers, potassium channel activators, estrogen-like compounds, testosterone-like compounds, benzodiazepines, adrenergic nerve inhibitors, antidiarrheal agents, HMG-CoA reductase inhibitors, smooth muscle relaxants, adenosine receptor modulators, adenylyl cyclase activators, endothelin receptor antagonists, bisphosphonates and cGMP-dependent protein kinase activators (e.g., cGMP mimetics).
PCT/US2002/007026 2001-03-06 2002-03-06 Compounds and methods for the treatment of urogenital disorders WO2002069906A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
IL15773402A IL157734A0 (en) 2001-03-06 2002-03-06 Pharmaceutical compositions for the treatment of urogenital disorders
JP2002569084A JP2005504721A (en) 2001-03-06 2002-03-06 Compounds and methods for the treatment of urogenital disorders
KR10-2003-7011650A KR20040052489A (en) 2001-03-06 2002-03-06 Compounds and methods for the treatment of urogenital disorders
CA002440141A CA2440141A1 (en) 2001-03-06 2002-03-06 Compounds and methods for the treatment of urogenital disorders
MXPA03007960A MXPA03007960A (en) 2001-03-06 2002-03-06 Compounds and methods for the treatment of urogenital disorders.
EP02723359A EP1383502A4 (en) 2001-03-06 2002-03-06 Compounds and methods for the treatment of urogenital disorders

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US27390101P 2001-03-06 2001-03-06
US60/273,901 2001-03-06
US33490301P 2001-10-24 2001-10-24
US60/334,903 2001-10-24

Publications (2)

Publication Number Publication Date
WO2002069906A2 WO2002069906A2 (en) 2002-09-12
WO2002069906A3 true WO2002069906A3 (en) 2003-11-20

Family

ID=26956497

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/007026 WO2002069906A2 (en) 2001-03-06 2002-03-06 Compounds and methods for the treatment of urogenital disorders

Country Status (8)

Country Link
US (2) US6987129B2 (en)
EP (1) EP1383502A4 (en)
JP (1) JP2005504721A (en)
KR (2) KR20040052489A (en)
CA (1) CA2440141A1 (en)
IL (1) IL157734A0 (en)
MX (1) MXPA03007960A (en)
WO (1) WO2002069906A2 (en)

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US6987129B2 (en) 2006-01-17
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