WO2002070029A3 - Porous beta-tricalcium phosphate granules and methods for producing same - Google Patents

Porous beta-tricalcium phosphate granules and methods for producing same Download PDF

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Publication number
WO2002070029A3
WO2002070029A3 PCT/US2002/005827 US0205827W WO02070029A3 WO 2002070029 A3 WO2002070029 A3 WO 2002070029A3 US 0205827 W US0205827 W US 0205827W WO 02070029 A3 WO02070029 A3 WO 02070029A3
Authority
WO
WIPO (PCT)
Prior art keywords
porous
tcp
methods
binder
tricalcium phosphate
Prior art date
Application number
PCT/US2002/005827
Other languages
French (fr)
Other versions
WO2002070029A2 (en
Inventor
Paresh S Dalal
Godofredo R Dimaano
Carol Ann Toth
Shailesh C Kulkarni
Original Assignee
Stryker Corp
Paresh S Dalal
Godofredo R Dimaano
Carol Ann Toth
Shailesh C Kulkarni
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27121998&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2002070029(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US09/798,518 external-priority patent/US20030049328A1/en
Application filed by Stryker Corp, Paresh S Dalal, Godofredo R Dimaano, Carol Ann Toth, Shailesh C Kulkarni filed Critical Stryker Corp
Priority to JP2002569200A priority Critical patent/JP2005505311A/en
Priority to AT02748362T priority patent/ATE429256T1/en
Priority to EP02748362A priority patent/EP1372748B1/en
Priority to CA002439813A priority patent/CA2439813C/en
Priority to AU2002306592A priority patent/AU2002306592B2/en
Priority to DE60232061T priority patent/DE60232061D1/en
Publication of WO2002070029A2 publication Critical patent/WO2002070029A2/en
Publication of WO2002070029A3 publication Critical patent/WO2002070029A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/12—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/811—Peptides or proteins is immobilized on, or in, an inorganic carrier

Abstract

A porous β-tricalcium phosphate material for bone implantation is provided. The multiple pores in the porous TCP body are separate discrete voids and are not interconnected. The pore size diameter is in the range of 20-500 µm, preferably 50-125 µm. The porous β-TCP material provides a carrier matrix for bioactive agents and can form a moldable putty composition upon the addition of a binder. Preferably, the bioactive agent is encapsulated in a biodegradable agent. The invention provides a kit and an implant device comprising the porous β-TCP, and a bioactive agent and a binder. The invention also provides an implementable prosthetic device comprising a prosthetic implant having a surface region, a porous β-TCP material disposed on the surface region optionally comprising at least a bioactive agent or a binder. Methods of producing the porous β-TCP material and including bone formation are also provided.
PCT/US2002/005827 2001-03-02 2002-02-26 Porous beta-tricalcium phosphate granules and methods for producing same WO2002070029A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP2002569200A JP2005505311A (en) 2001-03-02 2002-02-26 Porous β-tricalcium phosphate granules and method for producing the same
AT02748362T ATE429256T1 (en) 2001-03-02 2002-02-26 POROUS BETA-TRICALCIUM PHOSPHATE GRAINS AND A PRODUCTION METHOD
EP02748362A EP1372748B1 (en) 2001-03-02 2002-02-26 Porous beta-tricalcium phosphate granules and methods for producing same
CA002439813A CA2439813C (en) 2001-03-02 2002-02-26 Porous beta-tricalcium phosphate granules and methods for producing same
AU2002306592A AU2002306592B2 (en) 2001-03-02 2002-02-26 Porous beta-tricalcium phosphate granules and methods for producing same
DE60232061T DE60232061D1 (en) 2001-03-02 2002-02-26 POROUS BETA-TRICALCIUM PHOSPHATE GRAINS AND A PREPARATION METHOD

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US09/798,518 US20030049328A1 (en) 2001-03-02 2001-03-02 Porous beta-tricalcium phosphate granules and methods for producing same
US09/798,518 2001-03-02
US09/960,789 US6949251B2 (en) 2001-03-02 2001-09-21 Porous β-tricalcium phosphate granules for regeneration of bone tissue
US09/960,789 2001-09-21

Publications (2)

Publication Number Publication Date
WO2002070029A2 WO2002070029A2 (en) 2002-09-12
WO2002070029A3 true WO2002070029A3 (en) 2003-02-06

Family

ID=27121998

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/005827 WO2002070029A2 (en) 2001-03-02 2002-02-26 Porous beta-tricalcium phosphate granules and methods for producing same

Country Status (8)

Country Link
US (4) US6949251B2 (en)
EP (1) EP1372748B1 (en)
JP (3) JP2005505311A (en)
AT (1) ATE429256T1 (en)
CA (2) CA2439813C (en)
DE (1) DE60232061D1 (en)
ES (1) ES2325573T3 (en)
WO (1) WO2002070029A2 (en)

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US7390498B2 (en) 2008-06-24
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