WO2002071053A3 - Method and apparatus for chromatography-high field asymmetric waveform ion mobility spectrometry - Google Patents

Method and apparatus for chromatography-high field asymmetric waveform ion mobility spectrometry Download PDF

Info

Publication number
WO2002071053A3
WO2002071053A3 PCT/US2002/006266 US0206266W WO02071053A3 WO 2002071053 A3 WO2002071053 A3 WO 2002071053A3 US 0206266 W US0206266 W US 0206266W WO 02071053 A3 WO02071053 A3 WO 02071053A3
Authority
WO
WIPO (PCT)
Prior art keywords
high field
field asymmetric
section
ion
mobility spectrometry
Prior art date
Application number
PCT/US2002/006266
Other languages
French (fr)
Other versions
WO2002071053A2 (en
Inventor
Raanan A Miller
Erkinjon G Nazarov
Gary A Eiceman
Evgeny Krylov
Boris Tadjikov
Original Assignee
Draper Lab Charles S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Draper Lab Charles S filed Critical Draper Lab Charles S
Priority to CA2440429A priority Critical patent/CA2440429C/en
Priority to JP2002569924A priority patent/JP4063673B2/en
Priority to EP02748373A priority patent/EP1377820A2/en
Priority to AU2002306623A priority patent/AU2002306623A1/en
Publication of WO2002071053A2 publication Critical patent/WO2002071053A2/en
Publication of WO2002071053A3 publication Critical patent/WO2002071053A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
    • G01N27/622—Ion mobility spectrometry
    • G01N27/624—Differential mobility spectrometry [DMS]; Field asymmetric-waveform ion mobility spectrometry [FAIMS]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D59/00—Separation of different isotopes of the same chemical element
    • B01D59/44—Separation by mass spectrography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
    • G01N27/622—Ion mobility spectrometry
    • G01N27/623—Ion mobility spectrometry combined with mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
    • G01N27/64—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode using wave or particle radiation to ionise a gas, e.g. in an ionisation chamber
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0013—Miniaturised spectrometers, e.g. having smaller than usual scale, integrated conventional components
    • H01J49/0018—Microminiaturised spectrometers, e.g. chip-integrated devices, MicroElectro-Mechanical Systems [MEMS]
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0022—Portable spectrometers, e.g. devices comprising independent power supply, constructional details relating to portability
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N2030/0095—Separation specially adapted for use outside laboratory, e.g. field sampling, portable equipments
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7206—Mass spectrometers interfaced to gas chromatograph

Abstract

Method and apparatus for chromatographic high field asymmetric waveform ion mobility spectrometry, including a gas chromatographic analyzer section intimately coupled with an ionization section, an ion filter section, and an ion detection section, in which the sample compounds are at least somewhat separated prior to ionization, and ion filtering proceeds in a planar chamber under influence of high field asymmetric periodic signals, with detection integrated into the flow path, for producing accurate, real-time, orthogonal data for identification of a broad range of chemical compounds.
PCT/US2002/006266 2001-03-05 2002-03-04 Method and apparatus for chromatography-high field asymmetric waveform ion mobility spectrometry WO2002071053A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA2440429A CA2440429C (en) 2001-03-05 2002-03-04 Method and apparatus for chromatography-high field asymmetric waveform ion mobility spectrometry
JP2002569924A JP4063673B2 (en) 2001-03-05 2002-03-04 Method and apparatus for chromatographic high field asymmetric waveform ion mobility spectrometry
EP02748373A EP1377820A2 (en) 2001-03-05 2002-03-04 Method and apparatus for chromatography-high field asymmetric waveform ion mobility spectrometry
AU2002306623A AU2002306623A1 (en) 2001-03-05 2002-03-04 Method and apparatus for chromatography-high field asymmetric waveform ion mobility spectrometry

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/799,223 2001-03-05
US09/799,223 US6815668B2 (en) 1999-07-21 2001-03-05 Method and apparatus for chromatography-high field asymmetric waveform ion mobility spectrometry

Publications (2)

Publication Number Publication Date
WO2002071053A2 WO2002071053A2 (en) 2002-09-12
WO2002071053A3 true WO2002071053A3 (en) 2003-01-03

Family

ID=25175343

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/006266 WO2002071053A2 (en) 2001-03-05 2002-03-04 Method and apparatus for chromatography-high field asymmetric waveform ion mobility spectrometry

Country Status (6)

Country Link
US (5) US6815668B2 (en)
EP (1) EP1377820A2 (en)
JP (1) JP4063673B2 (en)
AU (1) AU2002306623A1 (en)
CA (1) CA2440429C (en)
WO (1) WO2002071053A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9410927B2 (en) 2004-11-04 2016-08-09 Micromass Uk Limited Mass spectrometer

Families Citing this family (149)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6504149B2 (en) * 1998-08-05 2003-01-07 National Research Council Canada Apparatus and method for desolvating and focussing ions for introduction into a mass spectrometer
AU1704200A (en) 1998-09-23 2000-04-10 Wisconsin Alumni Research Foundation Charge reduction in electrospray mass spectrometry
EP1073894B1 (en) * 1998-10-06 2010-10-06 The University Of Washington Charged particle beam detection system
US6690004B2 (en) 1999-07-21 2004-02-10 The Charles Stark Draper Laboratory, Inc. Method and apparatus for electrospray-augmented high field asymmetric ion mobility spectrometry
US6806463B2 (en) 1999-07-21 2004-10-19 The Charles Stark Draper Laboratory, Inc. Micromachined field asymmetric ion mobility filter and detection system
US6815668B2 (en) * 1999-07-21 2004-11-09 The Charles Stark Draper Laboratory, Inc. Method and apparatus for chromatography-high field asymmetric waveform ion mobility spectrometry
US7005632B2 (en) * 2002-04-12 2006-02-28 Sionex Corporation Method and apparatus for control of mobility-based ion species identification
US7057168B2 (en) * 1999-07-21 2006-06-06 Sionex Corporation Systems for differential ion mobility analysis
US6815669B1 (en) 1999-07-21 2004-11-09 The Charles Stark Draper Laboratory, Inc. Longitudinal field driven ion mobility filter and detection system
US7157700B2 (en) * 2001-06-30 2007-01-02 Sionex Corporation System for collection of data and identification of unknown ion species in an electric field
US7399958B2 (en) 1999-07-21 2008-07-15 Sionex Corporation Method and apparatus for enhanced ion mobility based sample analysis using various analyzer configurations
US7148477B2 (en) * 1999-07-21 2006-12-12 Sionex Corporation System for trajectory-based ion species identification
US7129482B2 (en) * 1999-07-21 2006-10-31 Sionex Corporation Explosives detection using differential ion mobility spectrometry
US7098449B1 (en) 1999-07-21 2006-08-29 The Charles Stark Draper Laboratory, Inc. Spectrometer chip assembly
US7200494B2 (en) * 2001-10-30 2007-04-03 Hitachi, Ltd. Method and apparatus for chromatographic data processing
EP1266395A2 (en) * 2000-03-14 2002-12-18 National Research Council of Canada Tandem faims/ion-trapping apparatus and method
AU2001239076A1 (en) * 2000-03-14 2001-09-24 National Research Council Canada Tandem high field asymmetric waveform ion mobility spectrometry (faims)/ion mobility spectrometry
US6593569B2 (en) * 2001-02-08 2003-07-15 Thermo Finnigan Llc Collisional gas delivery apparatus and method
US6649907B2 (en) 2001-03-08 2003-11-18 Wisconsin Alumni Research Foundation Charge reduction electrospray ionization ion source
US6797945B2 (en) 2001-03-29 2004-09-28 Wisconsin Alumni Research Foundation Piezoelectric charged droplet source
EP1387724A4 (en) * 2001-04-17 2006-03-15 Draper Lab Charles S Methods and apparatus for electrospray-augmented high field asymmetric ion mobility spectrometry
JP2005513414A (en) * 2001-06-30 2005-05-12 シオネックス・コーポレーション A system for data collection and identification of unknown ion species in an electric field.
US7119328B2 (en) * 2001-06-30 2006-10-10 Sionex Corporation System for DMS peak resolution
US7091481B2 (en) 2001-08-08 2006-08-15 Sionex Corporation Method and apparatus for plasma generation
US7274015B2 (en) * 2001-08-08 2007-09-25 Sionex Corporation Capacitive discharge plasma ion source
US6727496B2 (en) * 2001-08-14 2004-04-27 Sionex Corporation Pancake spectrometer
US6917036B2 (en) * 2002-02-08 2005-07-12 Ionalytics Corporation FAIMS with non-destructive detection of selectively transmitted ions
US7122794B1 (en) 2002-02-21 2006-10-17 Sionex Corporation Systems and methods for ion mobility control
FI118277B (en) * 2002-03-25 2007-09-14 Environics Oy Cell structure, instruments and method
US7095019B1 (en) 2003-05-30 2006-08-22 Chem-Space Associates, Inc. Remote reagent chemical ionization source
WO2004012231A2 (en) * 2002-07-25 2004-02-05 Sionex Corporation Method and apparatus for control of mobility-based ion species identification
US7417225B2 (en) * 2002-09-25 2008-08-26 Thermo Finnigan Llc Apparatus and method for adjustment of ion separation resolution in FAIMS
US7358504B2 (en) * 2002-09-25 2008-04-15 Thermo Finnigan Llc FAIMS apparatus and method for separating ions
WO2004040257A2 (en) * 2002-10-12 2004-05-13 Sionex Corporation NOx MONITOR USING DIFFERENTIAL MOBILITY SPECTROMETRY
US7078679B2 (en) 2002-11-27 2006-07-18 Wisconsin Alumni Research Foundation Inductive detection for mass spectrometry
WO2004081527A2 (en) * 2003-03-10 2004-09-23 Sionex Corporation Systems for differential ion mobility analysis
US6949741B2 (en) 2003-04-04 2005-09-27 Jeol Usa, Inc. Atmospheric pressure ion source
WO2004097396A1 (en) * 2003-04-24 2004-11-11 Sionex Corporation Apparatus and method for controlling ion behavior in ion mobility spectrometry
US7057166B2 (en) * 2003-06-27 2006-06-06 Ionalytics Corporation Method of separating ions
US7223970B2 (en) * 2003-09-17 2007-05-29 Sionex Corporation Solid-state gas flow generator and related systems, applications, and methods
EP1690074A2 (en) * 2003-11-25 2006-08-16 Sionex Corporation Mobility based apparatus and methods using dispersion characteristics, sample fragmentation, and/or pressure control to improve analysis of a sample
US7902498B2 (en) * 2003-12-18 2011-03-08 Dh Technologies Development Pte. Ltd. Methods and apparatus for enhanced ion based sample detection using selective pre-separation and amplification
CA2551991A1 (en) 2004-01-13 2005-07-28 Sionex Corporation Methods and apparatus for enhanced sample identification based on combined analytical techniques
WO2005074584A2 (en) * 2004-02-02 2005-08-18 Sionex Corporation Compact sample analysis systems and related methods using combined chromatography and mobility spectrometry techniques
EP1756561A1 (en) * 2004-04-28 2007-02-28 Sionex Corporation System and method for ion species analysis with enhanced condition control and data interpretation using differential mobility spectrometers
NZ553460A (en) * 2004-08-02 2010-06-25 Owlstone Ltd Ion mobility spectrometer
US7368709B2 (en) * 2004-08-05 2008-05-06 Thermo Finnigan Llc Low field mobility separation of ions using segmented cylindrical FAIMS
US7399959B2 (en) 2004-12-03 2008-07-15 Sionex Corporation Method and apparatus for enhanced ion based sample filtering and detection
US8754366B2 (en) * 2005-01-11 2014-06-17 Hamilton Sundstrand Corporation Tandem differential mobility ion mobility spectrometer for chemical vapor detection
US7703671B2 (en) * 2005-01-28 2010-04-27 Arrowhead Center, Inc. Monitoring device and security system
DE102005004325A1 (en) * 2005-01-31 2006-08-10 Bruker Daltonik Gmbh Ion mobility spectrometer and method of its operation
US8440968B2 (en) 2005-02-14 2013-05-14 Micromass Uk Limited Ion-mobility analyser
GB0503010D0 (en) * 2005-02-14 2005-03-16 Micromass Ltd Mass spectrometer
DE102005007746B4 (en) * 2005-02-18 2009-01-08 Dräger Safety AG & Co. KGaA Ion mobility spectrometer with parallel drift gas and ion carrier gas flow
GB0506665D0 (en) 2005-04-01 2005-05-11 Micromass Ltd Mass spectrometer
JP5219274B2 (en) * 2005-04-01 2013-06-26 マイクロマス ユーケー リミテッド Mass spectrometer
EP1920243B1 (en) * 2005-04-29 2015-09-09 DH Technologies Development Pte. Ltd. Compact gas chromatography and ion mobility based sample analysis systems, methods, and devices
US7138626B1 (en) 2005-05-05 2006-11-21 Eai Corporation Method and device for non-contact sampling and detection
US7351960B2 (en) * 2005-05-16 2008-04-01 Thermo Finnigan Llc Enhanced ion desolvation for an ion mobility spectrometry device
US7312444B1 (en) 2005-05-24 2007-12-25 Chem - Space Associates, Inc. Atmosperic pressure quadrupole analyzer
US7568401B1 (en) 2005-06-20 2009-08-04 Science Applications International Corporation Sample tube holder
DE102005031048A1 (en) * 2005-07-02 2007-01-04 Dräger Safety AG & Co. KGaA Ion mobility spectrometer uses unidirectional drift with larger dominant drift gas flow before detector electrode in separation area
GB0514843D0 (en) * 2005-07-20 2005-08-24 Microsaic Systems Ltd Microengineered nanospray electrode system
WO2007014303A2 (en) * 2005-07-26 2007-02-01 Sionex Corporation Ultra compact ion mobility based analyzer system and method
GB0808344D0 (en) * 2008-05-08 2008-06-18 Owlstone Ltd Sensor
US7449683B2 (en) * 2005-09-28 2008-11-11 Battelle Memorial Institute Method and apparatus for high-order differential mobility separations
US7576322B2 (en) 2005-11-08 2009-08-18 Science Applications International Corporation Non-contact detector system with plasma ion source
US7518108B2 (en) * 2005-11-10 2009-04-14 Wisconsin Alumni Research Foundation Electrospray ionization ion source with tunable charge reduction
FI119660B (en) * 2005-11-30 2009-01-30 Environics Oy Method and apparatus for measuring ion mobility in a gas
WO2007120373A2 (en) * 2006-01-26 2007-10-25 Sionex Corporation Differential mobility spectrometer analyzer and pre-filter apparatus, methods and systems
US20070205359A1 (en) * 2006-03-01 2007-09-06 Ulrich Bonne Electronic gas pump
US7758316B2 (en) * 2006-03-30 2010-07-20 Honeywell International Inc. Ion micro pump
US7964017B2 (en) * 2006-05-05 2011-06-21 General Dynamics Armament And Technical Products, Inc. Systems and methods for controlling moisture level in a gas
US7397027B2 (en) * 2006-05-30 2008-07-08 Agilent Technologies, Inc. Multi-channel high-field asymmetric waveform ion mobility spectrometry
US8963082B2 (en) * 2006-06-09 2015-02-24 Rapiscan Systems, Inc. Miniaturized ion mobility spectrometer
ES2406966T3 (en) * 2006-07-04 2013-06-10 Ramem, S.A. Differential mobility analyzer
US20080017790A1 (en) * 2006-07-20 2008-01-24 Owlstone Nanotech Inc. Smart FAIMS sensor
US7714277B2 (en) * 2006-07-20 2010-05-11 Owlstone Nanotech, Inc. Smart FAIMS sensor
WO2008094299A2 (en) * 2006-07-20 2008-08-07 Owlstone Nanotech, Inc. Smart faims sensor
US7813077B2 (en) * 2006-08-31 2010-10-12 International Business Machines Corporation Apparatus, system, and method for detecting a periodic sequence of servo signals
GB0620748D0 (en) 2006-10-19 2006-11-29 Smiths Group Plc Spectrometer apparatus
NZ549911A (en) * 2006-10-19 2009-04-30 Syft Technologies Ltd Improvements in or relating to SIFT-MS instruments
GB0621990D0 (en) * 2006-11-04 2006-12-13 Smiths Group Plc Detection
GB2445016B (en) * 2006-12-19 2012-03-07 Microsaic Systems Plc Microengineered ionisation device
GB0625481D0 (en) * 2006-12-20 2007-01-31 Smiths Group Plc Detector apparatus and pre-concentrators
GB0625479D0 (en) 2006-12-20 2007-01-31 Smiths Group Plc Detection apparatus
GB0625478D0 (en) 2006-12-20 2007-01-31 Smiths Group Plc Detection apparatus
GB0625480D0 (en) * 2006-12-20 2007-01-31 Smiths Group Plc Detector apparatus, pre-concentrators and methods
US8129676B2 (en) * 2007-01-05 2012-03-06 Sri International Surface enhanced Raman spectroscopy detection with ion separation pre-filter
JP5362586B2 (en) 2007-02-01 2013-12-11 サイオネックス コーポレイション Differential mobility spectrometer prefilter for mass spectrometer
EP1959476A1 (en) * 2007-02-19 2008-08-20 Technische Universität Hamburg-Harburg Mass spectrometer
EP2126961B1 (en) * 2007-02-24 2014-06-18 Sociedad Europea De Analisis Diferencial De Movilidad S.L. Method to accurately discriminate gas phase ions with several filtering devices in tandem
US7963146B2 (en) 2007-05-14 2011-06-21 General Dynamics Armament And Technical Products, Inc. Method and system for detecting vapors
US8123396B1 (en) 2007-05-16 2012-02-28 Science Applications International Corporation Method and means for precision mixing
US7863562B2 (en) * 2007-06-22 2011-01-04 Shimadzu Corporation Method and apparatus for digital differential ion mobility separation
DE102007052801B4 (en) * 2007-11-06 2010-10-07 Bruker Daltonik Gmbh Ion mobility spectrometer with substance collector
DE102007052802B4 (en) * 2007-11-06 2012-06-14 Bruker Daltonik Gmbh Ion mobility spectrometer and method of its operation
US8008617B1 (en) 2007-12-28 2011-08-30 Science Applications International Corporation Ion transfer device
DE102008006208B4 (en) 2008-01-26 2016-05-04 Dräger Safety AG & Co. KGaA Device for gas analysis
US7659505B2 (en) * 2008-02-01 2010-02-09 Ionics Mass Spectrometry Group Inc. Ion source vessel and methods
EP2263250B1 (en) 2008-03-20 2017-12-27 DH Technologies Development Pte. Ltd. Systems and methods for analyzing substances using a mass spectrometer
FI123930B (en) * 2008-04-03 2013-12-31 Environics Oy Method for measuring gases
JP2011522257A (en) * 2008-05-29 2011-07-28 ウオーターズ・テクノロジーズ・コーポレイシヨン Technology to construct precursor and product ion spectra by matching the retention times of precursor and product ions
CA2720244C (en) * 2008-05-30 2018-02-27 Dh Technologies Development Pte. Ltd. Method and system for vacuum driven differential mobility spectrometer/mass spectrometer interface with adjustable resolution and selectivity
GB2459580A (en) * 2008-05-30 2009-11-04 Secr Defence Use of low molecular weight solvents in HiFAWS
GB2461346B (en) * 2008-07-04 2013-02-13 Smiths Group Plc Electrical connectors
US8013295B2 (en) * 2008-11-21 2011-09-06 Schlumberger Technology Corporation Ion mobility measurements for formation fluid characterization
GB0903908D0 (en) * 2009-03-06 2009-04-22 Micromass Ltd A dual mass spectrometry system
US8071957B1 (en) 2009-03-10 2011-12-06 Science Applications International Corporation Soft chemical ionization source
EP2237307B1 (en) * 2009-03-30 2014-05-14 Vidal de Miguel, Guillermo Method and apparatus to produce steady beams of mobility selected ions via time-dependent electric fields
EP2422219B1 (en) 2009-04-24 2020-11-18 Illinois Tool Works Inc. Clean corona gas ionization for static charge neutralization
US8038775B2 (en) 2009-04-24 2011-10-18 Peter Gefter Separating contaminants from gas ions in corona discharge ionizing bars
CN101571508B (en) * 2009-06-16 2012-10-10 清华大学 High-field asymmetric waveform ion mobility spectrometer with multi-layer plate structure
US8716655B2 (en) * 2009-07-02 2014-05-06 Tricorntech Corporation Integrated ion separation spectrometer
US8416552B2 (en) * 2009-10-23 2013-04-09 Illinois Tool Works Inc. Self-balancing ionized gas streams
US8143591B2 (en) 2009-10-26 2012-03-27 Peter Gefter Covering wide areas with ionized gas streams
DE112011102013B4 (en) * 2010-06-17 2016-09-29 Step Sensortechnik Und Elektronik Pockau Gmbh Method for ion mobility spectrometry
PL218395B1 (en) * 2011-05-17 2014-11-28 Wojskowy Inst Chemii I Radiometrii Ion mobility spectrometer chamber
US8450681B2 (en) * 2011-06-08 2013-05-28 Mks Instruments, Inc. Mass spectrometry for gas analysis in which both a charged particle source and a charged particle analyzer are offset from an axis of a deflector lens, resulting in reduced baseline signal offsets
US8502138B2 (en) 2011-07-29 2013-08-06 Sharp Kabushiki Kaisha Integrated ion mobility spectrometer
TR201909601T4 (en) * 2012-04-23 2019-07-22 Environics Oy Method and structure for chemical analysis.
CN102683150B (en) * 2012-05-04 2014-09-24 中国科学院合肥物质科学研究院 High-field asymmetry ion mobility spectrometer (FAIMS) for realizing trace substance full spectrum scanning
JP5997650B2 (en) * 2013-04-15 2016-09-28 株式会社日立ハイテクノロジーズ Analysis system
US9625428B2 (en) * 2013-10-11 2017-04-18 Waters Technologies Corporation Modulated flame gas flow rates in flame-based detectors
CN104634703B (en) * 2013-11-08 2019-01-25 郑秀惠 Air ion Mobility Spectrum Analysis method and instrument
CN104716013A (en) * 2013-12-13 2015-06-17 中国科学院大连化学物理研究所 Novel high-field asymmetric ion mobility spectrometry device
CN104020237B (en) * 2014-06-24 2016-01-20 武汉矽感科技有限公司 Can with the FastGC post modifying device of ionic migration spectrometer coupling
US9925547B2 (en) * 2014-08-26 2018-03-27 Tsi, Incorporated Electrospray with soft X-ray neutralizer
WO2016046513A1 (en) * 2014-09-26 2016-03-31 Micromass Uk Limited Accurate mobility chromatograms
CN104515824B (en) * 2014-12-31 2016-08-24 同方威视技术股份有限公司 Gaseous substance analytical equipment and gas phase gatherer
US10495550B2 (en) * 2016-05-20 2019-12-03 Pulmostics Limited Identification of chemicals in a sample using GC/SAW and Raman spectroscopy
US10245730B2 (en) * 2016-05-24 2019-04-02 Asustek Computer Inc. Autonomous mobile robot and control method thereof
CN105912001A (en) * 2016-07-04 2016-08-31 上海木爷机器人技术有限公司 Robot
US10458962B2 (en) * 2016-07-22 2019-10-29 Pulmostics Limited Temperature control for surface acoustic wave sensor
CN107153757A (en) * 2017-04-05 2017-09-12 常俊宇 A kind of coastal waters organic contamination source automatic monitoring method
GB2566326A (en) * 2017-09-11 2019-03-13 Owlstone Inc Ion mobility filter
KR102241870B1 (en) 2018-02-23 2021-04-16 주식회사 엘지화학 High-speed Processing Gas Chromatography System for Analyzing Additives and Analysis Method Using the Same
CN108845054A (en) * 2018-07-12 2018-11-20 同方威视技术股份有限公司 Item detection systems and method, electronic equipment, storage medium
CN109856230B (en) * 2019-01-30 2021-09-21 山东博戎伝创信息科技有限公司 Organic compound residue analysis method and device and intelligent monitoring system thereof
CN113574629A (en) * 2019-03-22 2021-10-29 Dh科技发展私人贸易有限公司 Unknown Compound elution assay
US10930485B2 (en) * 2019-03-25 2021-02-23 Hamilton Sundstrand Corporation Ion source for an ion mobility spectrometer
JP7296631B2 (en) 2019-12-17 2023-06-23 東海電子株式会社 gas analysis system
CN113740443A (en) * 2020-05-29 2021-12-03 同方威视技术股份有限公司 Detector for detecting drugs and metabolites thereof
US11092569B1 (en) 2020-07-05 2021-08-17 Cannabix Technologies Inc. Apparatus and methods for detection of molecules
CN112730592B (en) * 2020-12-28 2023-03-31 上海新漫传感科技有限公司 Gas detection system device and detection method thereof
CN113035686B (en) * 2021-03-03 2023-06-16 桂林电子科技大学 Ion source, FAIMS device and method for improving resolution and sensitivity of FAIMS device
JPWO2022219825A1 (en) * 2021-04-16 2022-10-20
WO2022224299A1 (en) * 2021-04-19 2022-10-27 シャープディスプレイテクノロジー株式会社 Detector
KR102500948B1 (en) * 2021-10-01 2023-02-20 한국전자기술연구원 Hazardous material detection device and method through time-varying IMS data processing

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5420424A (en) * 1994-04-29 1995-05-30 Mine Safety Appliances Company Ion mobility spectrometer
WO1997038302A1 (en) * 1996-04-04 1997-10-16 Mine Safety Appliances Company Recirculating filtration system for use with a transportable ion mobility spectrometer
US5736739A (en) * 1996-04-04 1998-04-07 Mine Safety Appliances Company Recirculating filtration system for use with a transportable ion mobility spectrometer in gas chromatography applications
US5811059A (en) * 1995-10-16 1998-09-22 The United States Of America As Represented By The Secretary Of The Army Automated, on-demand ion mobility spectrometry analysis of gas chromatograph effluents
WO1999021212A1 (en) * 1997-10-22 1999-04-29 Ids Intelligent Detection Systems, Inc. A sample trapping ion mobility spectrometer for portable molecular detection
WO2001008197A1 (en) * 1999-07-21 2001-02-01 The Charles Stark Draper Laboratory, Inc. Micromachined field asymmetric ion mobility filter and detection system
US20010030285A1 (en) * 1999-07-21 2001-10-18 Miller Raanan A. Method and apparatus for chromatography-high field asymmetric waveform Ion mobility spectrometry

Family Cites Families (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US787765A (en) * 1904-02-16 1905-04-18 Cie Generale De Phonographes Cinematographes & App De Prec Phonograph.
US2818507A (en) 1946-03-22 1957-12-31 Roy J Britten Velocity selector method for the separation of isotopes
US2615135A (en) 1950-06-20 1952-10-21 Jr William E Glenn Mass analyzing apparatus
US2919348A (en) 1956-07-05 1959-12-29 Bierman Aron Device for the separation of gas ions
US3535512A (en) 1966-07-21 1970-10-20 Varian Associates Double resonance ion cyclotron mass spectrometer for studying ion-molecule reactions
US3621240A (en) 1969-05-27 1971-11-16 Franklin Gro Corp Apparatus and methods for detecting and identifying trace gases
US3619605A (en) 1969-06-25 1971-11-09 Phillips Petroleum Co Mass spectrometer method and apparatus employing high energy metastable ions to generate sample ions
US3648046A (en) 1970-05-18 1972-03-07 Granville Phillips Co Quadrupole gas analyzer comprising four flat plate electrodes
US3931589A (en) 1974-03-21 1976-01-06 The United States Of America As Represented By The Secretary Of The Navy Perforated wall hollow-cathode ion laser
NL7415318A (en) 1974-11-25 1976-05-28 Philips Nv WIENFILTER.
CA1076714A (en) * 1976-01-20 1980-04-29 Donald F. Hunt Positive and negative ion recording system for mass spectrometer
US4025818A (en) 1976-04-20 1977-05-24 Hughes Aircraft Company Wire ion plasma electron gun
FR2363364A1 (en) 1976-09-07 1978-03-31 Thomson Csf ISOTOPIC SEPARATION PROCESS AND INSTALLATION FOR ITS IMPLEMENTATION
USRE33344E (en) 1977-04-22 1990-09-18 Finnigan Corporation Apparatus and method for detecting negative ions
US4163151A (en) 1977-12-28 1979-07-31 Hughes Aircraft Company Separated ion source
US4201921A (en) 1978-07-24 1980-05-06 International Business Machines Corporation Electron beam-capillary plasma flash x-ray device
SU966583A1 (en) 1980-03-10 1982-10-15 Предприятие П/Я А-1342 Method of analysis of impurities in gases
US4315153A (en) 1980-05-19 1982-02-09 Hughes Aircraft Company Focusing ExB mass separator for space-charge dominated ion beams
FR2514905A1 (en) 1981-10-21 1983-04-22 Commissariat Energie Atomique DEVICE FOR MEASURING IONIC CURRENT PRODUCED BY ION BEAM
SU1337934A2 (en) 1986-04-09 1987-09-15 Предприятие П/Я А-1882 Method of analysis of impurities in gases
US4761545A (en) 1986-05-23 1988-08-02 The Ohio State University Research Foundation Tailored excitation for trapped ion mass spectrometry
FI75055C (en) 1986-06-03 1988-04-11 Puumalaisen Tutkimuslaitos Oy Method for observing gas content of ingredients.
SU1412447A1 (en) 1986-11-03 1998-06-20 И.А. Буряков Drift spectrometer to detect microimpurities of substances in gases
SU1405489A1 (en) 1986-11-03 1998-06-10 И.А. Буряков Method of analyzing traces of substances in gases
US4885500A (en) 1986-11-19 1989-12-05 Hewlett-Packard Company Quartz quadrupole for mass filter
SU1485808A1 (en) 1987-03-30 1998-06-10 И.А. Буряков Method of analyzing traces of substances in gases
JPH0193039A (en) 1987-10-02 1989-04-12 Hitachi Ltd Ion source
SU1627984A2 (en) 1988-07-20 1991-02-15 Предприятие П/Я А-1882 Method of gas analysis for impurities
DE3914838A1 (en) 1989-05-05 1990-11-08 Spectrospin Ag ION CYCLOTRON RESONANCE SPECTROMETER
US4931640A (en) 1989-05-19 1990-06-05 Marshall Alan G Mass spectrometer with reduced static electric field
US5281494A (en) * 1990-05-04 1994-01-25 Inco Limited Nickel hydroxide
US5218203A (en) * 1991-03-22 1993-06-08 Georgia Tech Research Corporation Ion source and sample introduction method and apparatus using two stage ionization for producing sample gas ions
GB9116222D0 (en) 1991-07-26 1991-09-11 Graseby Ionics Ltd Introduction of samples into ion mobility spectrameter
US5144127A (en) 1991-08-02 1992-09-01 Williams Evan R Surface induced dissociation with reflectron time-of-flight mass spectrometry
EP0556411B1 (en) 1991-09-11 1998-12-09 Sumitomo Electric Industries, Ltd. Quadrupole electrode and manufacture thereof
US5298745A (en) 1992-12-02 1994-03-29 Hewlett-Packard Company Multilayer multipole
US5492867A (en) 1993-09-22 1996-02-20 Westinghouse Elect. Corp. Method for manufacturing a miniaturized solid state mass spectrograph
US5536939A (en) 1993-09-22 1996-07-16 Northrop Grumman Corporation Miniaturized mass filter
US5401963A (en) 1993-11-01 1995-03-28 Rosemount Analytical Inc. Micromachined mass spectrometer
US5455417A (en) 1994-05-05 1995-10-03 Sacristan; Emilio Ion mobility method and device for gas analysis
KR0156602B1 (en) 1994-07-08 1998-12-01 황해웅 Ion mobility analyzer
GB2296369A (en) 1994-12-22 1996-06-26 Secr Defence Radio frequency ion source
JP3361528B2 (en) * 1995-07-03 2003-01-07 株式会社 日立製作所 Mass spectrometer
US5654544A (en) 1995-08-10 1997-08-05 Analytica Of Branford Mass resolution by angular alignment of the ion detector conversion surface in time-of-flight mass spectrometers with electrostatic steering deflectors
US5852302A (en) 1996-01-30 1998-12-22 Shimadzu Corporation Cylindrical multiple-pole mass filter with CVD-deposited electrode layers
US5801379A (en) 1996-03-01 1998-09-01 Mine Safety Appliances Company High voltage waveform generator
US5723861A (en) 1996-04-04 1998-03-03 Mine Safety Appliances Company Recirculating filtration system for use with a transportable ion mobility spectrometer
US5763876A (en) 1996-04-04 1998-06-09 Mine Safety Appliances Company Inlet heating device for ion mobility spectrometer
US5644131A (en) 1996-05-22 1997-07-01 Hewlett-Packard Co. Hyperbolic ion trap and associated methods of manufacture
US5869344A (en) * 1996-07-19 1999-02-09 Micromass Uk Limited Apparatus and methods for the analysis of trace constituents in gases
US6051832A (en) 1996-08-20 2000-04-18 Graseby Dynamics Limited Drift chambers
US5838003A (en) 1996-09-27 1998-11-17 Hewlett-Packard Company Ionization chamber and mass spectrometry system containing an asymmetric electrode
DE19650612C2 (en) 1996-12-06 2002-06-06 Eads Deutschland Gmbh Ion-mobility spectrometer
US6055151A (en) 1997-03-06 2000-04-25 Sarnoff Corp Multilayer ceramic circuit boards including embedded components
JP3648915B2 (en) * 1997-03-31 2005-05-18 株式会社島津製作所 Gas chromatograph mass spectrometer
US6498342B1 (en) * 1997-06-02 2002-12-24 Advanced Research & Technology Institute Ion separation instrument
US6323482B1 (en) * 1997-06-02 2001-11-27 Advanced Research And Technology Institute, Inc. Ion mobility and mass spectrometer
US6049052A (en) 1997-06-03 2000-04-11 California Institute Of Technology Miniature micromachined quadrupole mass spectrometer array and method of making the same
AU7805498A (en) 1997-06-03 1998-12-21 California Institute Of Technology Miniature micromachined quadrupole mass spectrometer array and method of making the same
US6157031A (en) 1997-09-17 2000-12-05 California Institute Of Technology Quadropole mass analyzer with linear ion trap
US5965882A (en) 1997-10-07 1999-10-12 Raytheon Company Miniaturized ion mobility spectrometer sensor cell
US5789745A (en) 1997-10-28 1998-08-04 Sandia Corporation Ion mobility spectrometer using frequency-domain separation
AU3180099A (en) 1998-01-08 1999-07-26 Government of the United States of America as represented by the Administrator of the National Aeronautics and Space Administration (NASA), The Paraelectric gas flow accelerator
US6124592A (en) 1998-03-18 2000-09-26 Technispan Llc Ion mobility storage trap and method
DE19861106B4 (en) 1998-04-07 2008-01-10 Eads Deutschland Gmbh Ionization chamber for an ion mobility spectrometer (IMS)
US6107628A (en) 1998-06-03 2000-08-22 Battelle Memorial Institute Method and apparatus for directing ions and other charged particles generated at near atmospheric pressures into a region under vacuum
US6066848A (en) 1998-06-09 2000-05-23 Combichem, Inc. Parallel fluid electrospray mass spectrometer
JP2000036280A (en) 1998-07-17 2000-02-02 Shimadzu Corp Ionization device
EP1102986B8 (en) 1998-08-05 2006-01-11 National Research Council Canada Apparatus and method for atmospheric pressure 3-dimensional ion trapping
US6713758B2 (en) * 1998-08-05 2004-03-30 National Research Council Of Canada Spherical side-to-side FAIMS
US6621077B1 (en) * 1998-08-05 2003-09-16 National Research Council Canada Apparatus and method for atmospheric pressure-3-dimensional ion trapping
US6504149B2 (en) * 1998-08-05 2003-01-07 National Research Council Canada Apparatus and method for desolvating and focussing ions for introduction into a mass spectrometer
US6259106B1 (en) * 1999-01-06 2001-07-10 Etec Systems, Inc. Apparatus and method for controlling a beam shape
US6618712B1 (en) * 1999-05-28 2003-09-09 Sandia Corporation Particle analysis using laser ablation mass spectroscopy
US7098449B1 (en) * 1999-07-21 2006-08-29 The Charles Stark Draper Laboratory, Inc. Spectrometer chip assembly
US7057168B2 (en) * 1999-07-21 2006-06-06 Sionex Corporation Systems for differential ion mobility analysis
US6815669B1 (en) * 1999-07-21 2004-11-09 The Charles Stark Draper Laboratory, Inc. Longitudinal field driven ion mobility filter and detection system
US6690004B2 (en) * 1999-07-21 2004-02-10 The Charles Stark Draper Laboratory, Inc. Method and apparatus for electrospray-augmented high field asymmetric ion mobility spectrometry
US7005632B2 (en) * 2002-04-12 2006-02-28 Sionex Corporation Method and apparatus for control of mobility-based ion species identification
US6512224B1 (en) 1999-07-21 2003-01-28 The Charles Stark Draper Laboratory, Inc. Longitudinal field driven field asymmetric ion mobility filter and detection system
US7148477B2 (en) * 1999-07-21 2006-12-12 Sionex Corporation System for trajectory-based ion species identification
US6806463B2 (en) * 1999-07-21 2004-10-19 The Charles Stark Draper Laboratory, Inc. Micromachined field asymmetric ion mobility filter and detection system
US7399958B2 (en) * 1999-07-21 2008-07-15 Sionex Corporation Method and apparatus for enhanced ion mobility based sample analysis using various analyzer configurations
US7129482B2 (en) * 1999-07-21 2006-10-31 Sionex Corporation Explosives detection using differential ion mobility spectrometry
US6509562B1 (en) * 1999-09-16 2003-01-21 Rae Systems, Inc. Selective photo-ionization detector using ion mobility spectrometry
WO2001022049A2 (en) 1999-09-24 2001-03-29 Haley Lawrence V A novel ion-mobility based device using an oscillatory high-field ion separator with a multi-channel array charge collector
AU2001239076A1 (en) 2000-03-14 2001-09-24 National Research Council Canada Tandem high field asymmetric waveform ion mobility spectrometry (faims)/ion mobility spectrometry
US6806466B2 (en) * 2000-03-14 2004-10-19 National Research Council Canada Parallel plate geometry FAIMS apparatus and method
EP1266395A2 (en) * 2000-03-14 2002-12-18 National Research Council of Canada Tandem faims/ion-trapping apparatus and method
US6459079B1 (en) * 2000-07-11 2002-10-01 The United States As Represented By The Secretary Of The Navy Shipboard chemical agent monitor-portable (SCAMP)
CA2364676C (en) 2000-12-08 2010-07-27 Mds Inc., Doing Business As Mds Sciex Ion mobility spectrometer incorporating an ion guide in combination with an ms device
JP4587604B2 (en) * 2001-06-13 2010-11-24 富士通セミコンダクター株式会社 Manufacturing method of semiconductor device
JP2005513414A (en) * 2001-06-30 2005-05-12 シオネックス・コーポレーション A system for data collection and identification of unknown ion species in an electric field.
JP4088063B2 (en) * 2001-11-14 2008-05-21 株式会社東芝 Power MOSFET device
US6917036B2 (en) * 2002-02-08 2005-07-12 Ionalytics Corporation FAIMS with non-destructive detection of selectively transmitted ions
US7122794B1 (en) * 2002-02-21 2006-10-17 Sionex Corporation Systems and methods for ion mobility control
CA2551991A1 (en) * 2004-01-13 2005-07-28 Sionex Corporation Methods and apparatus for enhanced sample identification based on combined analytical techniques
EP1756561A1 (en) * 2004-04-28 2007-02-28 Sionex Corporation System and method for ion species analysis with enhanced condition control and data interpretation using differential mobility spectrometers
US7368709B2 (en) * 2004-08-05 2008-05-06 Thermo Finnigan Llc Low field mobility separation of ions using segmented cylindrical FAIMS
US7388195B2 (en) * 2004-09-30 2008-06-17 Charles Stark Draper Laboratory, Inc. Apparatus and systems for processing samples for analysis via ion mobility spectrometry
EP1920243B1 (en) * 2005-04-29 2015-09-09 DH Technologies Development Pte. Ltd. Compact gas chromatography and ion mobility based sample analysis systems, methods, and devices

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5420424A (en) * 1994-04-29 1995-05-30 Mine Safety Appliances Company Ion mobility spectrometer
US5811059A (en) * 1995-10-16 1998-09-22 The United States Of America As Represented By The Secretary Of The Army Automated, on-demand ion mobility spectrometry analysis of gas chromatograph effluents
WO1997038302A1 (en) * 1996-04-04 1997-10-16 Mine Safety Appliances Company Recirculating filtration system for use with a transportable ion mobility spectrometer
US5736739A (en) * 1996-04-04 1998-04-07 Mine Safety Appliances Company Recirculating filtration system for use with a transportable ion mobility spectrometer in gas chromatography applications
WO1999021212A1 (en) * 1997-10-22 1999-04-29 Ids Intelligent Detection Systems, Inc. A sample trapping ion mobility spectrometer for portable molecular detection
WO2001008197A1 (en) * 1999-07-21 2001-02-01 The Charles Stark Draper Laboratory, Inc. Micromachined field asymmetric ion mobility filter and detection system
US20010030285A1 (en) * 1999-07-21 2001-10-18 Miller Raanan A. Method and apparatus for chromatography-high field asymmetric waveform Ion mobility spectrometry

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BURYAKOV I A ET AL: "A NEW METHOD OF SEPARATION OF MULTI-ATOMIC IONS BY MOBILITY AT ATMOSPHERIC PRESSURE USING A HIGH-FREQUENCY AMPLITUDE-ASYMMETRIC STRONG ELECTRIC FIELD", INTERNATIONAL JOURNAL OF MASS SPECTROMETRY AND ION PROCESSES, ELSEVIER SCIENTIFIC PUBLISHING CO. AMSTERDAM, NL, vol. 128, 1993, pages 143 - 148, XP000865595, ISSN: 0168-1176 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9410927B2 (en) 2004-11-04 2016-08-09 Micromass Uk Limited Mass spectrometer

Also Published As

Publication number Publication date
JP4063673B2 (en) 2008-03-19
US7176453B2 (en) 2007-02-13
JP2004529461A (en) 2004-09-24
CA2440429C (en) 2012-07-10
CA2440429A1 (en) 2002-09-12
US7365316B2 (en) 2008-04-29
EP1377820A2 (en) 2004-01-07
US20010030285A1 (en) 2001-10-18
US6815668B2 (en) 2004-11-09
US7211791B2 (en) 2007-05-01
AU2002306623A1 (en) 2002-09-19
US20080128612A1 (en) 2008-06-05
US20050017163A1 (en) 2005-01-27
US20050263699A1 (en) 2005-12-01
WO2002071053A2 (en) 2002-09-12
US20050029443A1 (en) 2005-02-10

Similar Documents

Publication Publication Date Title
WO2002071053A3 (en) Method and apparatus for chromatography-high field asymmetric waveform ion mobility spectrometry
KR100975774B1 (en) Determination of Antibiotics by High Performance Liquid Chromatography and Mass Spectrometry
CN102192950B (en) Device for analyzing gas phase chemical components of cigarette smoke on line
CN109755097B (en) Quadrupole mass spectrometer and use method thereof
WO2006130474A3 (en) Multi-beam ion mobility time-of-flight mass spectrometer with bipolar ion extraction and zwitterion detection
WO2007120373A3 (en) Differential mobility spectrometer analyzer and pre-filter apparatus, methods and systems
WO2004011426A3 (en) Method for automated, large-scale measurement of the molecular flux rates of the proteome or the organeome using mass spectrometry
CN104634895B (en) A kind of method that Ultra Performance Liquid Chromatography triple quadrupole bar tandem mass spectrometer detects 6 kinds of sweeting agents in Chinese liquor simultaneously
WO2007014303A3 (en) Ultra compact ion mobility based analyzer system and method
WO2007041692A3 (en) Microfluidic detection of analytes
WO2008036616A3 (en) Apparatus and method for field asymmetric ion mobility spectrometry combined with mass spectrometry.
WO2008046111A3 (en) A sampling system for containment and transfer of ions into a spectroscopy system
WO2007140349A3 (en) Apparatus for holding solids for use with surface ionization technology
WO2007067759A3 (en) Methods and devices for concentration and fractionation of analytes for chemical analysis
WO2003067237A3 (en) Faims apparatus and method using carrier gases that contain a trace amount of a dopant species
WO2005052546A3 (en) Mobility bases apparatus and methods using dispersion characteristics to improve analysis of a sample
WO2001069647A3 (en) Tandem high field asymmetric waveform ion mobility spectrometry (faims)/tandem mass spectrometry
CA2555359A1 (en) Fingerprinting of complex hydrocarbon containing mixtures
WO2006124100A3 (en) Method for quantitative analysis of mixtures of compounds
WO2007060421A3 (en) Mass spectrometer
WO2008101998A3 (en) Method to accurately discriminate gas phase ions with several filtering devices in tandem
US10276358B2 (en) Chemically modified ion mobility separation apparatus and method
CN104364641B (en) The quantization of the analyte in serum and other bio-matrixes
Nieddu et al. Determination of four thiophenethylamine designer drugs (2C‐T‐4, 2C‐T‐8, 2C‐T‐13, 2C‐T‐17) in human urine by capillary electrophoresis/mass spectrometry
CN105548327A (en) Rapid detection for improving sensitivity of ion mobility spectrometry

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG UZ VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG UZ VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 2002569924

Country of ref document: JP

Ref document number: 2440429

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2002748373

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2002748373

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642