WO2002074316A1 - Method of treating inflammatory disorders of the gastrointestinal tract using topical active corticosteroids - Google Patents
Method of treating inflammatory disorders of the gastrointestinal tract using topical active corticosteroids Download PDFInfo
- Publication number
- WO2002074316A1 WO2002074316A1 PCT/US2002/007676 US0207676W WO02074316A1 WO 2002074316 A1 WO2002074316 A1 WO 2002074316A1 US 0207676 W US0207676 W US 0207676W WO 02074316 A1 WO02074316 A1 WO 02074316A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- topically active
- dosage forms
- formulated
- active corticosteroid
- kit
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
Definitions
- This invention relates to methods for the treatment of inflammatory disorders of the gastrointestinal tract and/or bowel of a patient in need of such treatment.
- IBD Inflammatory bowel disease
- Ulcerative colitis is an inflammatory disorder of the large bowel (colon and rectum) characterized by inflammation and ulceration of the innermost lining of the colon. Symptoms include abdominal pain, abdominal cramping, decreased appetite and weight loss, tenesmus, and diarrhea, which may be accompanied by rectal bleeding. Inflammation associated with ulcerative colitis can involve the entire length of the colon but is usually greatest in the rectum and may extend continuously for varying distances along the colon, occurring most typically in a proximal to distal pattern of inflammation.
- Crohn's disease is another type of inflammatory bowel disease.
- Crohn's disease can affect any portion of the digestive tract, but is most commonly seen in the distal portion of the small intestine. Approximately 40% of Crohn's disease patients have inflammatory disease localized in the ileocecal region, 30-35% of the patients have disease in the proximal small bowel and the stomach, and about 25% of patients have disease localized in the large bowel. Unlike ulcerative colitis, Crohn's disease can exhibit areas of normal intestine between regions of affected intestine, termed "skip" areas.
- Crohn's disease is distinguishable from ulcerative colitis in that ulcerative colitis affects only the innermost lining of the colon, while in Crohn's disease the entire thicl ⁇ iess of the bowel wall is involved, often resulting in fistulae.
- Treatment of IBDs usually involves administration of aminosalicylates (i.e., 5-aminosalicylic acid or sulfasalazine); immunomodulatory compounds (i.e., azathioprine, cyclosporine or 6- mercaptopurine); steroid drugs (i.e., prednisone, methylprenisolone, or budesonide); or monoclonal antibodies directed to cytokines, such as TNF-alpha, and other inflammatory mediators.
- Anti-TNF alpha antibodies have been used successfully to treat steroid-refractory fistulating Crohn's disease.
- Aminosalicylates are used to treat mild to moderate cases of IBD and are usually the first line therapy for patients initially presenting with Crohn's disease.
- immunomodulatory drugs such as methotrexate or azathioprine are routinely given to patients who fail to respond to aminosalicylates.
- the immunomodulatory drugs may take up to three months to begin to take effect and can also result in increased risk of neoplastic diseases.
- surgery to remove the affected areas of the colon or bowel may be required. Surgery is inevitably required to treat chronic Crohn's disease of decades duration.
- steroid drugs which are potent anti-inflammatory agents.
- Steroid drugs may be administered orally, intravenously, via an enema or via a suppository, depending on the location, severity and extent of the disease. In most instances, steroid drugs are given orally and occasionally parenterally. Steroids are typically given to ablate the initial symptoms of inflammation and are rarely given repetitively over long term because of the side effects. Oral administration is most preferred for its ease and effectiveness.
- the steroid drugs used routinely in treating IBD are prednisone, methylprednisone or prednisolone.
- IBDs such as ulcerative colitis and Crohn's disease
- Steroids with topical, but moderate systemic activity have been characterized and have been used in the treatment of IBD.
- a variety of steroid analogues has been developed over the last several decades. These steroids characteristically have high activity in vitro in binding to steroid receptors, but in vivo are rapidly metabolized in the liver to inactive or less active metabolites. High degree of first pass metabolism in the liver largely bypasses the undesirable toxic side effects of steroid administration.
- a topically active steroid To be effective in treatment of IBD, a topically active steroid must be formulated in such a manner to reach the affected inflamed portions of the gastrointestinal tract. This has been accomplished by producing galenic formulations of topical steroids that can be administered as enemas to treat ulcerative colitis or controlled release formulations that can be taken orally to treat inflammation in the small or large intestine. Controlled release formulations are typically designed to release drug conditionally from a polymer matrix, for instance, when encountering a change in pH of the milieu, or by simple erosion of the matrix and diffusion of the drug from the matrix. For example, U.S. Patent No.
- U.S. Patent No. 6,096,731 further discloses prophylaxis of liver and cellular damage arising from graft versus host disease using beclomethasone formulated in gelcapsules and enteric coated gel capsules.
- a method of administration of an oral pharmaceutical product to patients suffering from inflammatory disorders of the gastrointestinal tract comprises orally administering to the patient at least two different dosage forms of a therapeutically effective amount of a topically active corticosteroid or a pharmaceutically active salt thereof, such as beclomethasone dipropionate.
- Figure 1 illustrates mean plasma concentrations of 17-BMP after oral administration of 6 mg of BDP as IR, EC, or a Combination of IR and EC Tablets under fasted conditions to healthy volunteers.
- Figure 2 shows mean plasma concentrations of BOH after oral administration of 6 mg of BDP as IR, EC, or a combination of IR and EC Tablets under fasted conditions to healthy volunteers.
- the present invention provides methods for treating IBDs that comprises oral administration of a topically active corticosteroid, or a pharmaceutically acceptable salt thereof, in a dosage which is therapeutically effective for topical treatment of an IBD, but which does not permit development of levels of the drug in the systemic circulation sufficient to produce the side effects usually found with steroid drugs.
- a therapeutically effective dose of the selected topically active corticosteroid drug is introduced into the gastrointestinal tract as an oral agent and that portion of the dose that crosses the wall and enters the circulation is effectively metabolized and inactivated before reaching the systemic circulation.
- the topically active corticosteroid may be one that does not readily cross the intestinal or stomach wall. The side effects are therefore substantially reduced.
- topically active refers to a drug that has a high topical activity on the gastrointestinal mucosa at a low dosage, or, alternatively, one that has a high topical activity and which does not readily cross the gastrointestinal tract wall.
- therapeutically effective dosage refers to an amount of the drug that is sufficient to reduce or eliminate symptoms of an IBD in a patient.
- systemic circulation refers to that portion of the circulation which is distal to the site of steroid drug metabolism, in which a steady-state level of the drug in the circulation has been achieved. The present invention has been primarily developed for use in the treatment of inflammatory bowel disorders of the gastrointestinal tract, e.g.
- pharmaceutically acceptable salt refers to derivatives of the free acid or base forms of the disclosed compounds that are modified by addition of appropriate salts. Examples include mineral or organic acid salts of basic residues, such as amines, and alkali or organic salts of acidic residues, such as carboxylic acids.
- the topically active corticosteroid is administered in at least two separate dosage forms, including at least one each of an immediate release and an enteric coated composition.
- An "immediate release” formulation is one that is intended and formulated to dissolve and have activity in the in the initial portions of the gastrointestinal tract, such as the stomach, the duodenum and the proximal small bowel.
- An "enteric coated” formulation is one that is intended and formulated to dissolve and have activity in the lower intestinal tract, such as the distal small intestine, the ileocecal region or colon (large intestine).
- the two separate dosage forms may contain equal or different amounts of the topically active corticosteroid. While the present invention is not intended to be limited to this embodiment, the embodiment in which the topically active corticosteroid in two different dosage forms encompasses the basic and novel characteristics of the invention.
- the two separate dosage forms may also contain another drug, such as other corticosteroids, a non-steroidal anti-inflammatory drug, an immunosuppressive agent or an antibiotic.
- a non-steroidal anti-inflammatory drug such as prednisone, prednisolone, triamcinolone, alclometasone, desoximetasone, and betamethasone.
- non-steroidal anti-inflammatory drugs include, for example, aspirin, ibuprofen, naproxen, indomethacin, diclofenac, sulindac, piroxicam, etodolac, ketoprofen, and tolmetin.
- immunosuppressive agents include, for example, cyclosporin A and analogs thereof, FK506 and analogs thereof, azathioprine, mycophenilic acid, rapamycin, methotrexate, and tacrolimus.
- antibiotics include penicillin, erythromycin, ampicillin, ciprofloxacin, vancomycin, stretomycin, polymyxin, tetracycline and their derivatives.
- the preferred topically active corticosteroid drugs suitable for use in the methods of the present invention are beclomethasone dipropionate (BDP) and betamethasone-17-valerate, due to their high topical activity and effectiveness at low dosages.
- the most preferred drug is beclomethasone 17,21 -dipropionate, due to its high topical anti- inflammatory activity.
- the invention is not restricted thereto, and is intended to encompass any steroid drug which is substantially topically active.
- Other such steroid drugs include, for example, alclometasone dipropionate, busedonide, 22S busesonide, 22R budesonide, beclomethasone- 17-monopropionate, clobetasol propionate, diflorasone diacetate, flunisolide, flurandrenolide, fluticasone propionate, halobetasol propionate, halcinocide, mometasone furcate, and triamcinalone acetonide.
- the preferred dosage level of the topically active corticosteroid will generally range from 0.1 mg/day to 8 mg/day, and more typically range from 2 mg/day to 4 mg/day. More preferably, the dosage is not more than about 2 mg, preferably not more than about 1 mg, administered at a time, e.g. daily.
- the dosage level should be such that the drug does not enter the systemic circulation to any significant extent, i.e., in amounts high enough to cause adverse systemic effects, and hence these effects resulting from their presence in the systemic circulation are avoided. Alternatively, the dosage level should be such that the amounts that cross the wall of the gastrointestinal tract are less than that required to induce the undesirable side effects associated with such drugs.
- the patient when delivered using two different dosage forms, the patient receives the topically active corticosteroid throughout the entire gastrointestinal tract, from the stomach to the rectum.
- one dosage form may be formulated as a gelcapsule
- the second dosage form may be formulated as an enteric coated gelcapsule.
- the separate dosage forms are administered to a patient as separate tablets, pills, troches, gelcaps and the like.
- the separate dosage forms are designed to contain a first dosage form containing a topical corticosteroid that releases in the stomach and a second dosage form containing a topical corticosteroid that releases in the intestine, such that the simultaneous administration of the two dosage forms results in a combination of quick release and slow release of the topical corticosteroid.
- the separate dosage forms are combined in a single formulation form, i.e., a tablet or a single gelcap, for oral administration to a patient.
- the topical corticosteroid may be formulated in microspheres, polymer microspheres, hydrogels, water-in-oil emulsions, oil-in-water emulsions, liposomes, micelles, or reverse micelles to control the release of the topical steroid in the small intestine, and separately the topical corticosteroid is added external to the microspheres or drug delivery vehicle in a suitable matrix to allow for rapid release of the topical corticosteroid.
- a formulation would contain an inner core containing, for example, an enteric coated formulation of the topical corticosteroid, and an outer shell surrounding the core and containing a rapid release formulation of the drug.
- Suitable polymeric systems for entrapment of topical steroids in microspheres, hydrogels, and nanospheres include, but are not limited to, single component polymer systems and combinations of polyalkylene oxide homopolymers, polyethylene glycol, polypropylene glycols, polyoxyethylenated polyols, polyols, polyimines, polypeptides, polyglutamic acid, polylysine, polyaspartic acid, polyacid esters, polyacrylic acid, alginate, hyaluronic acid, chitosan, carboxyniethyl cellulose, hydroxypropylmethyl cellulose oligosaccharides, polysaccharides, carageenan and salts thereof, dextran, deacetylated chitosan, gelatin, block co
- Beclomethasone 17,21 -dipropionate has the following structure:
- topically active corticosteroid used in the methods of the present invention may be formulated for oral administration by techniques well known to those in the in the drug formulation field, including formulation as a capsule, pill, troche, coated microsphere with specific dissolution qualities, or emulsion.
- Suitable capsules or pills generally contain from 0.1 mg to 8 mg of the topically active corticosteroid, and typically about 1 mg, plus optional fillers, including but not limited to binders, such as microcrystalline cellulose, gum tragacanth or gelatin; fillers, such as starch or lactose; disintegrating agents, such as con starch or alginic acid; sweetening agents, such as sucrose, saccharin or phenylalanine; or flavoring agents, such as peppermint, lemon, cinnamon, methyl salicylate, or orange flavoring.
- the capsules or pills may be coated with a variety of materials, such as sugars, shellacs or cellulose acetate phthalate.
- the capsules, microspheres or pills may be made to dissolve within various location of the intestinal tract.
- enteric-coated capsules prepared with a coating of cellulose acetate phthalate are known to remain intact in the stomach and dissolve in the alkaline environment of the small bowel, thus delivering its content to the small bowl and colon.
- Other useful enteric coatings may include hydroxypropyl methylcellulose phthalate, polyvinyl acetate phthalate, and those polymers based on methacrylic acid-methacrylic acid ester copolymers with acidic ionizable groups known to those in the art under the trade name "Eudragit" (Roehm GmbH & Co., Darmstadt, Germany).
- the topically active corticosteroid may also be formulated as an oil-in-water emulsion, a water-in-oil emulsion, a multiple emulsion, (w/o/w), entrapped or associated with liposomes, and/or organized lipid phases.
- Lipid-based delivery systems such as emulsion systems, microemulsions systems, or lipid particulate systems are based on the use of polar lipids and related amphiphilic surfactant molecules to control the interaction of hydrophobic molecules with water.
- delivery systems for hydrophobic drugs have also required the inclusion of organic solvents that are water miscible in order to increase the molecular interactions between drugs and lipid or surfactant components.
- Lipids and surfactants are differentiable from short and long chain hydrocarbons in that they are amphiphilic molecules, having both hydrophilic and hydrophobic moieties.
- Surfactants are conveniently classified on an empirical scale known as the hydrophile-lipophile balance (HLB) which runs from about 1 to about 45 and from about 1 to about 20 for non-ionic surfactants. HLB values closer to 1 represent surfactants with more lipophilic character, while HLB values that are greater than about 10 represent more hydrophilic surfactants.
- HLB hydrophile-lipophile balance
- Phospholipids characteristically form bilayer membranes in water, whereas at low concentration of other polar lipids in water, micellar structures form.
- micelles are either spherical, typically containing 50-100 lipid molecules, or rod-shaped or disc-shaped macrostructures. In each of these cases, the hydrocarbon tails form the interior of the micelle and polar head groups are in contact with water.
- reverse-type micelles, or inverse micelles form.
- the conventional micellar phase is also known as the LI phase.
- the reverse micellar phase is also known as L2. In the L2 phase, water forms the internal phase and the hydrophobic tails of the lipid form the continuous phase.
- micelles and pharmaceutical compositions containing micelles, have been extensively studied and are described in detail in the literature; see, e.g., Remington's Pharmaceutical Sciences, 17th ed. (1985).
- micelles can incorporate hydrophobic therapeutic agents in the hydrocarbon core of the micelle.
- Oil-in-water (o/w) emulsions are also commonly formed from oil(s), surfactant(s), and an aqueous phase.
- oils used that comprise drug delivery systems are made to solubilize lipophilic drugs to make them more effective and less toxic.
- Oils used in typical emulsions are any of a number of oils such as mineral, vegetable, animal, essential and synthetic oils, or mixtures thereof.
- oils rich in triglycerides such as safflower oil, cottonseed oil, olive oil or soybean oil are used.
- a triglyceride-containing formulation suitable for delivering hydrophobic therapeutic agents is an oil-in-water emulsion containing the therapeutic agent.
- Such emulsions contain the hydrophobic therapeutic agent such as beclomethasone diproprionate solubilized in an oil phase that is dispersed in an aqueous environment with the aid of a surfactant or a combination of surfactants. Therefore, one approach to making suitable formulations of hydrophobic topical steroid drugs is to solubilize it in an oil and to disperse this oil phase in an aqueous solution. Depending on whether an oil is a solid or liquid at the ambient temperature, the oil-in-water emulsion can be characterized as a solid lipid particulate. Surfactants are also required to form solid emulsions.
- the dispersion may be stabilized by emulsifying agents and provided in emulsion form.
- drugs dissolved in the oil phase or the solid lipid core phase may be dispersed by mechanical force to create microdroplets or microspheres suspended in the aqueous phase that are stable in storage as a pharmaceutical preparation.
- the formation of a stable oil-in-water emulsion may be enhanced by the use of surfactants that form the interface between the strictly hydrophobic oil and water.
- surfactants that form the interface between the strictly hydrophobic oil and water.
- either large droplets characteristic of oil-in-water emulsions or much smaller structures characteristic of micellar structures are formed.
- Further control over size of droplets or particles can be obtained by high pressure homogenization or similar shear forces. Lipid particles are typically formed at higher ambient temperatures to melt the hydrophobic components.
- Hydrophobic therapeutic agents while poorly soluble in aqueous solution, may be sufficiently lipophilic such that therapeutically effective concentrations can be prepared in triglyceride-based solvents forming colloidal oil particles, with broad particle size distribution and relatively large sizes, ranging from several hundred nanometers to several microns in diameter.
- Reverse micelles containing oil(s), surfactant(s) and an aqueous phase are also characterized as water-in-oil microemulsions (see Constantinides, P.P. Lipid Microemulsions for Improving Drug Dissolution and Oral Absorption : Physical and Biopharmaceutical Aspects, Pharm. Res. 12 (11) 1561-1572, 1995 and references therein).
- liquid crystalline structures can also co-exist in mixtures of polar lipid and water, analogous to normal and inverse micelles, including hexagonal phases and inverse hexagonal.
- simple reverse micelles water/amphiphile
- Microemulsion systems are ternary or quaternary systems typically formed from an oil phase, a surfactant, and water.
- U.S. Patent No. 5,707,648 describes microemulsions that contain an oil phase, an aqueous phase, and a mixture of surfactants. The solubilization of one phase into another in a microemulsion system is affected by a balance of attractive and repulsive forces.
- Microemulsions are thermodynamically stable, such that the droplets will not coalesce and precipitate over time.
- the diameter of microemulsion droplets is in the range of 10 to 200 nanometers, while emulsion droplets are generally greater than a micron.
- microemulsion droplets can be considered as amonolayer of surfactant.
- a microemulsion can be characterized by the amount of the dispersed phase solubilized in the continuous phase.
- Microemulsions have traditionally been formed using, in addition to the components described above, a cosurfactant, which are generally short chain alcohols, ethanol or butanol, glycols such as propylene glycol and polyethylene glycol, or medium chain alcohols, amines, or acids.
- a cosurfactant which are generally short chain alcohols, ethanol or butanol, glycols such as propylene glycol and polyethylene glycol, or medium chain alcohols, amines, or acids.
- the emulsions or lipid formulations of beclomethasone may be suitably encapsulated in gelcaps.
- topically active corticosteroid is orally administered such that it is topically administered to the intestinal and/or liver tissue.
- oral administration as that term is used herein, is intended to exclude systemic administration, such as is achieved by intravenous injection. Rather, the methods are intended to achieve administration of the topically active corticosteroid so that it has high topical activity on intestinal and/or liver tissue with little or no systemic availability.
- the high topical activity is achieved by any of a number of means, known to those in the art, of limiting the distribution of the drug to the intestinal mucosa.
- the drug may be formulated so as to coat the surface of the intestinal mucosa with a high local concentration of the drug, or formulated so as to inhibit traversal of the drug across the intestinal mucosal into the systemic circulation.
- Such limited distribution results in fewer side effects, which is a significant advantage of this invention.
- the topically active corticosteroid can achieve high concentrations throughout the intestinal mucosa where this initiating immune reaction is taking place.
- Example 1 Formulation of beclomethasone diproprionate in immediate release (IR) and enteric coated (EC) tablets.
- Plasma samples were stored on ice until processing and storage. Plasma samples were separated by centrifugation and then frozen at ⁇ 20°C until assayed.
- Plasma samples were analyzed for BDP, 17-BMP, and BOH concentrations using validated liquid chromatography / mass spectrometry / mass spectrometry (LC/MS/MS) methods.
- Elimination half-life (t _) was calculated according to the following equation.
- AUC ⁇ ⁇ UC 0 _ t + ⁇ L
- Table 2 17-BMP and BOH Pharmacokinetic Parameters after Oral Administration of 6 mg of BDP as IR, EC, or a Combination of IR and EC Tablets under Fasted Conditions to Healthy Volunteers
- IR and EC BDP tablet formulations release BDP after oral administration, with approximately 20% greater bioavailability from the latter. Concurrent administration of IR and EC tablets resulted in plasma concentrations similar to those of the EC alone.
Abstract
Description
Claims
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002441007A CA2441007C (en) | 2001-03-15 | 2002-03-15 | Method of treating inflammatory disorders of the gastrointestinal tract using topical active corticosteroids |
EP02723424A EP1392321B1 (en) | 2001-03-15 | 2002-03-15 | Method of treating inflammatory disorders of the gastrointestinal tract using topical active corticosteroids |
AU2002254205A AU2002254205B2 (en) | 2001-03-15 | 2002-03-15 | Method of treating inflammatory disorders of the gastrointestinal tract using topical active corticosteroids |
JP2002573023A JP2005508836A (en) | 2001-03-15 | 2002-03-15 | Method for treating inflammatory diseases of the gastrointestinal tract using locally acting corticosteroids |
IL15792102A IL157921A0 (en) | 2001-03-15 | 2002-03-15 | Method of treating inflammatory disorders of the gastrointestinal tract using topical active corticosteroids |
NZ528607A NZ528607A (en) | 2001-03-15 | 2002-03-15 | Method of treating inflammatory GI disorders using topically active corticosteroids to reduce symptoms without causing the side effects associated with systemic steroid administration |
AT02723424T ATE477804T1 (en) | 2001-03-15 | 2002-03-15 | METHOD FOR TREATING INFLAMMATORY DISEASES OF THE DIGESTIVE TRACT USING TOPICAL CORTICOSTEROIDS |
DK02723424.4T DK1392321T3 (en) | 2001-03-15 | 2002-03-15 | Process for the treatment of inflammatory diseases of the gastrointestinal tract using topically active corticosteroids |
DE60237363T DE60237363D1 (en) | 2001-03-15 | 2002-03-15 | METHOD FOR THE TREATMENT OF INFLAMMATORY DISEASES OF DIGESTIVE STRENGTH WITH TOPIC EFFECTIVE CORTICOSTEROIDS |
IL157921A IL157921A (en) | 2001-03-15 | 2003-09-14 | Use of topically active corticosteroids for treating inflammatory bowel disease |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US27601301P | 2001-03-15 | 2001-03-15 | |
US60/276,013 | 2001-03-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2002074316A1 true WO2002074316A1 (en) | 2002-09-26 |
Family
ID=23054783
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2002/007676 WO2002074316A1 (en) | 2001-03-15 | 2002-03-15 | Method of treating inflammatory disorders of the gastrointestinal tract using topical active corticosteroids |
Country Status (11)
Country | Link |
---|---|
US (1) | US8263582B2 (en) |
EP (1) | EP1392321B1 (en) |
JP (3) | JP2005508836A (en) |
AT (1) | ATE477804T1 (en) |
AU (1) | AU2002254205B2 (en) |
CA (1) | CA2441007C (en) |
DE (1) | DE60237363D1 (en) |
DK (1) | DK1392321T3 (en) |
IL (2) | IL157921A0 (en) |
NZ (1) | NZ528607A (en) |
WO (1) | WO2002074316A1 (en) |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1567505A2 (en) * | 2002-11-08 | 2005-08-31 | Encysive Pharmaceuticals Inc. | Combination products with carboxylic acid derivatives that inhibit the binding of integrins to their receptors and other therapeutic compounds |
JP2006508121A (en) * | 2002-11-05 | 2006-03-09 | アラーガン、インコーポレイテッド | Botulinum toxin formulation for oral administration |
JP4814107B2 (en) * | 2003-12-24 | 2011-11-16 | サムヤン コーポレイション | Nanoparticle composition for oral administration containing water-soluble drug and method for producing the same |
ITMI20101512A1 (en) * | 2010-08-06 | 2012-02-07 | Sofar Spa | COMPOSITIONS OF BECLOMETASONE DIPROPIONIONATO IN GASTRORESISTANT MICROSPHERES WITH MODIFIED RELEASE AND PROCESS FOR THEIR ACHIEVEMENT |
US8324192B2 (en) | 2005-11-12 | 2012-12-04 | The Regents Of The University Of California | Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract |
US8497258B2 (en) | 2005-11-12 | 2013-07-30 | The Regents Of The University Of California | Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract |
US8679545B2 (en) | 2005-11-12 | 2014-03-25 | The Regents Of The University Of California | Topical corticosteroids for the treatment of inflammatory diseases of the gastrointestinal tract |
US8865692B2 (en) | 2007-11-13 | 2014-10-21 | Meritage Pharma, Inc | Compositions for the treatment of gastrointestinal inflammation |
US10293052B2 (en) | 2007-11-13 | 2019-05-21 | Meritage Pharma, Inc. | Compositions for the treatment of gastrointestinal inflammation |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090143328A1 (en) * | 2001-08-13 | 2009-06-04 | Mcdonald George | Method of Treating Cancer by Administration of Topical Active Corticosteroids |
US20030113366A1 (en) * | 2001-12-14 | 2003-06-19 | Macgregor Alexander | Reverse-micellar delivery system for controlled transportation and enhanced absorption of agents |
US20050059583A1 (en) | 2003-09-15 | 2005-03-17 | Allergan, Inc. | Methods of providing therapeutic effects using cyclosporin components |
EP1706098A4 (en) * | 2003-11-26 | 2012-08-15 | Supernus Pharmaceuticals Inc | Micellar systems useful for delivery of lipophilic or hydrophobic compounds |
SE0401031D0 (en) | 2004-04-22 | 2004-04-22 | Duocort Ab | A new glucocorticoid replacement therapy |
US20080102114A1 (en) * | 2004-04-23 | 2008-05-01 | Panduranga Rao Koritala | Microparticles and Nanoparticles for the Transmucosal Delivery of Therapeutic and Diagnostic Agents |
US20060004185A1 (en) * | 2004-07-01 | 2006-01-05 | Leese Richard A | Peptide antibiotics and peptide intermediates for their prepartion |
US7151085B2 (en) * | 2004-11-15 | 2006-12-19 | Allergan, Inc. | Therapeutic methods using cyclosporine components |
US7135455B2 (en) * | 2004-11-15 | 2006-11-14 | Allergan, Inc | Methods for the therapeutic use of cyclosporine components |
CA2583244A1 (en) * | 2004-12-30 | 2006-07-06 | Dor Biopharma, Inc. | Treatment of graft-versus-host disease and leukemia with beclomethasone dipropionate and prednisone |
SG174026A1 (en) | 2006-08-03 | 2011-09-29 | Nitec Pharma Ag | Delayed-release glucocorticoid treatment of rheumatoid disease |
CA2683415C (en) | 2007-04-04 | 2020-12-08 | Sigmoid Pharma Limited | An oral pharmaceutical composition |
US20100216754A1 (en) * | 2007-11-13 | 2010-08-26 | Meritage Pharma, Inc. | Compositions for the treatment of inflammation of the gastrointestinal tract |
US20090123551A1 (en) * | 2007-11-13 | 2009-05-14 | Meritage Pharma, Inc. | Gastrointestinal delivery systems |
US20090264392A1 (en) * | 2008-04-21 | 2009-10-22 | Meritage Pharma, Inc. | Treating eosinophilic esophagitis |
CA2745930C (en) * | 2008-12-08 | 2017-05-02 | Soligenix, Inc. | Topically active steroids for use in radiation and chemotherapeutics injury |
US8343912B2 (en) | 2008-12-23 | 2013-01-01 | Biosource Pharm, Inc. | Antibiotic compositions for the treatment of gram negative infections |
CA2749646A1 (en) * | 2009-01-26 | 2010-07-29 | Nitec Pharma Ag | Delayed-release glucocorticoid treatment of asthma |
NZ582836A (en) * | 2009-01-30 | 2011-06-30 | Nitec Pharma Ag | Delayed-release glucocorticoid treatment of rheumatoid arthritis by improving signs and symptoms, showing major or complete clinical response and by preventing from joint damage |
EP2416811B1 (en) * | 2009-04-09 | 2015-09-09 | Actamax Surgical Materials LLC | Hydrogel tissue adhesive having reduced degradation time |
US20110097401A1 (en) * | 2009-06-12 | 2011-04-28 | Meritage Pharma, Inc. | Methods for treating gastrointestinal disorders |
US8415307B1 (en) | 2010-06-23 | 2013-04-09 | Biosource Pharm, Inc. | Antibiotic compositions for the treatment of gram negative infections |
GB201020032D0 (en) | 2010-11-25 | 2011-01-12 | Sigmoid Pharma Ltd | Composition |
PT2543357T (en) * | 2011-07-07 | 2018-04-30 | Holy Stone Healthcare Co Ltd | Composition for use in treating and preventing inflammation related disorder |
US10154964B2 (en) * | 2011-09-07 | 2018-12-18 | Cosmo Technologies Limited | Controlled release and taste masking oral pharmaceutical composition |
GB201304662D0 (en) * | 2013-03-14 | 2013-05-01 | Sigmoid Pharma Ltd | Compositions |
EP3027659B1 (en) | 2013-07-29 | 2020-12-09 | Actamax Surgical Materials LLC | Low swell tissue adhesive and sealant formulations |
GB201319791D0 (en) | 2013-11-08 | 2013-12-25 | Sigmoid Pharma Ltd | Formulations |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5643602A (en) * | 1989-11-22 | 1997-07-01 | Astra Aktiebolag | Oral composition for the treatment of inflammatory bowel disease |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2260384C3 (en) * | 1972-12-09 | 1979-11-29 | Hoechst Ag, 6000 Frankfurt | Oral corticosteroid preparation |
SE8903914D0 (en) * | 1989-11-22 | 1989-11-22 | Draco Ab | ORAL COMPOSITION FOR THE TREATMENT OF INFLAMMATORY BOWEL DISEASES |
US5316772A (en) * | 1990-12-19 | 1994-05-31 | Solvay & Cie, S.A. (Societe Anonyme) | Bilayered oral pharmaceutical composition with pH dependent release |
US5286731A (en) * | 1991-09-17 | 1994-02-15 | American Home Products Corporation | Method of treating immunoinflammatory bowel disease |
JPH0840941A (en) * | 1994-07-29 | 1996-02-13 | Kanegafuchi Chem Ind Co Ltd | Remedial preparation for inflammatory bowel disease |
US6540993B1 (en) * | 1995-06-27 | 2003-04-01 | Wyeth | Method of treating inflammatory bowel disease using a topical formulation of IL-11 |
JPH1067657A (en) * | 1996-06-18 | 1998-03-10 | Otsuka Pharmaceut Co Ltd | Multiple unit type long-acting pharmaceutical preparation |
JPH10231242A (en) * | 1997-02-20 | 1998-09-02 | Taiyo Yakuhin Kogyo Kk | Long-acting diclofenac sodium composition |
CN1277550A (en) * | 1997-09-11 | 2000-12-20 | 尼科梅德丹麦有限公司 | Modified release multiple-units compositions of non-steroid anti-inflammatory drug sbstances (NSAIDS) |
IT1301947B1 (en) * | 1998-07-28 | 2000-07-20 | Chiesi Farma Spa | PHARMACEUTICAL FORMULATIONS OF BECLOMETASONE DEPROPIONED FOR THE TREATMENT OF CHRONIC INFLAMMATORY DISEASES OF THE MUCOSA |
US6632451B2 (en) * | 1999-06-04 | 2003-10-14 | Dexcel Pharma Technologies Ltd. | Delayed total release two pulse gastrointestinal drug delivery system |
HUP0303930A3 (en) * | 2001-01-26 | 2012-09-28 | Univ Emory | Methods of inducing organ transplant tolerance and correcting hemoglobinopathies |
-
2002
- 2002-03-15 JP JP2002573023A patent/JP2005508836A/en not_active Withdrawn
- 2002-03-15 CA CA002441007A patent/CA2441007C/en not_active Expired - Lifetime
- 2002-03-15 WO PCT/US2002/007676 patent/WO2002074316A1/en active IP Right Grant
- 2002-03-15 AT AT02723424T patent/ATE477804T1/en not_active IP Right Cessation
- 2002-03-15 US US10/098,968 patent/US8263582B2/en not_active Expired - Lifetime
- 2002-03-15 AU AU2002254205A patent/AU2002254205B2/en not_active Expired
- 2002-03-15 DK DK02723424.4T patent/DK1392321T3/en active
- 2002-03-15 EP EP02723424A patent/EP1392321B1/en not_active Expired - Lifetime
- 2002-03-15 NZ NZ528607A patent/NZ528607A/en not_active IP Right Cessation
- 2002-03-15 DE DE60237363T patent/DE60237363D1/en not_active Expired - Lifetime
- 2002-03-15 IL IL15792102A patent/IL157921A0/en unknown
-
2003
- 2003-09-14 IL IL157921A patent/IL157921A/en active IP Right Grant
-
2010
- 2010-01-12 JP JP2010003527A patent/JP2010106038A/en not_active Withdrawn
-
2013
- 2013-07-29 JP JP2013156233A patent/JP5617015B2/en not_active Expired - Lifetime
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5643602A (en) * | 1989-11-22 | 1997-07-01 | Astra Aktiebolag | Oral composition for the treatment of inflammatory bowel disease |
Cited By (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2014065728A (en) * | 2002-11-05 | 2014-04-17 | Allergan Inc | Botulinum toxin formulations for oral administration |
JP2006508121A (en) * | 2002-11-05 | 2006-03-09 | アラーガン、インコーポレイテッド | Botulinum toxin formulation for oral administration |
JP2011219491A (en) * | 2002-11-05 | 2011-11-04 | Allergan Inc | Botulinum toxin formulation for oral administration |
KR101081667B1 (en) * | 2002-11-05 | 2011-11-09 | 알러간, 인코포레이티드 | Botulinum toxin formulations for oral administration |
EP1567505A4 (en) * | 2002-11-08 | 2009-07-01 | Schering Corp | Combination products with carboxylic acid derivatives that inhibit the binding of integrins to their receptors and other therapeutic compounds |
EP1567505A2 (en) * | 2002-11-08 | 2005-08-31 | Encysive Pharmaceuticals Inc. | Combination products with carboxylic acid derivatives that inhibit the binding of integrins to their receptors and other therapeutic compounds |
JP4814107B2 (en) * | 2003-12-24 | 2011-11-16 | サムヤン コーポレイション | Nanoparticle composition for oral administration containing water-soluble drug and method for producing the same |
US8679545B2 (en) | 2005-11-12 | 2014-03-25 | The Regents Of The University Of California | Topical corticosteroids for the treatment of inflammatory diseases of the gastrointestinal tract |
US8324192B2 (en) | 2005-11-12 | 2012-12-04 | The Regents Of The University Of California | Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract |
US8497258B2 (en) | 2005-11-12 | 2013-07-30 | The Regents Of The University Of California | Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract |
US11413296B2 (en) | 2005-11-12 | 2022-08-16 | The Regents Of The University Of California | Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract |
US8975243B2 (en) | 2005-11-12 | 2015-03-10 | The Regents Of The University Of California | Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract |
US9119863B2 (en) | 2005-11-12 | 2015-09-01 | The Regents Of The University Of California | Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract |
US9782347B2 (en) | 2005-11-12 | 2017-10-10 | The Regents Of The University Of California | Topical corticosteroids for the treatment of inflammatory diseases of the gastrointestinal tract |
US11197822B2 (en) | 2005-11-12 | 2021-12-14 | The Regents Of The University Of California | Topical corticosteroids for the treatment of inflammatory diseases of the gastrointestinal tract |
US10272037B2 (en) | 2005-11-12 | 2019-04-30 | The Regents Of The University Of California | Topical corticosteroids for the treatment of inflammatory diseases of the gastrointestinal tract |
US10293052B2 (en) | 2007-11-13 | 2019-05-21 | Meritage Pharma, Inc. | Compositions for the treatment of gastrointestinal inflammation |
US8865692B2 (en) | 2007-11-13 | 2014-10-21 | Meritage Pharma, Inc | Compositions for the treatment of gastrointestinal inflammation |
US9050368B2 (en) | 2007-11-13 | 2015-06-09 | Meritage Pharma, Inc. | Corticosteroid compositions |
US11357859B2 (en) | 2007-11-13 | 2022-06-14 | Viropharma Biologics Llc | Compositions for the treatment of gastrointestinal inflammation |
ITMI20101512A1 (en) * | 2010-08-06 | 2012-02-07 | Sofar Spa | COMPOSITIONS OF BECLOMETASONE DIPROPIONIONATO IN GASTRORESISTANT MICROSPHERES WITH MODIFIED RELEASE AND PROCESS FOR THEIR ACHIEVEMENT |
US10028917B2 (en) | 2010-08-06 | 2018-07-24 | Sofar Spa | Beclomethasone dipropionate compositions in modified-release gastro-resistant microspheres and process for obtaining them |
EP3009130A1 (en) * | 2010-08-06 | 2016-04-20 | SOFAR S.p.A. | Beclomethasone dipropionate compositions in modified-release gastro-resistant microspheres |
WO2012017385A3 (en) * | 2010-08-06 | 2012-04-19 | Sofar Spa | Beclomethasone dipropionate compositions in modified-release gastro-resistant microspheres and process for obtaining them |
Also Published As
Publication number | Publication date |
---|---|
ATE477804T1 (en) | 2010-09-15 |
DE60237363D1 (en) | 2010-09-30 |
CA2441007A1 (en) | 2002-09-26 |
DK1392321T3 (en) | 2010-11-29 |
CA2441007C (en) | 2009-06-09 |
JP2005508836A (en) | 2005-04-07 |
AU2002254205B2 (en) | 2007-05-10 |
JP2010106038A (en) | 2010-05-13 |
US8263582B2 (en) | 2012-09-11 |
NZ528607A (en) | 2007-11-30 |
EP1392321A1 (en) | 2004-03-03 |
JP2013216700A (en) | 2013-10-24 |
EP1392321A4 (en) | 2007-10-24 |
IL157921A0 (en) | 2004-03-28 |
JP5617015B2 (en) | 2014-10-29 |
US20030055028A1 (en) | 2003-03-20 |
EP1392321B1 (en) | 2010-08-18 |
IL157921A (en) | 2011-07-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU2002254205B2 (en) | Method of treating inflammatory disorders of the gastrointestinal tract using topical active corticosteroids | |
AU2002254205A1 (en) | Method of treating inflammatory disorders of the gastrointestinal tract using topical active corticosteroids | |
JP6059688B2 (en) | "Oral pharmaceutical composition" | |
US9980902B2 (en) | Method for treating intestinal fibrosis | |
US20200171123A1 (en) | Compositions for use in the treatment of ulcerative colitis | |
EP2642978B1 (en) | Immunomodulatory compositions comprising hydralazine and cyclosporine a for the treatment of gastrointestinal disorders | |
RU2435568C2 (en) | Tablets with active ingredient release which takes place in specified place at specified time | |
US20240091304A1 (en) | Formulations comprising cyclosporin a | |
JPH09510708A (en) | Hydrophobic drug delivery system | |
EP3215127B1 (en) | Compositions comprising cyclosporin | |
WO2020011938A1 (en) | Glucocorticoids for the topical treatment of autoimmune gastritis | |
NZ731512B2 (en) | Compositions comprising cyclosporin |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG UZ VN YU ZA ZM ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
WWE | Wipo information: entry into national phase |
Ref document number: 157921 Country of ref document: IL |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2441007 Country of ref document: CA Ref document number: 2002254205 Country of ref document: AU |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2002573023 Country of ref document: JP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 528607 Country of ref document: NZ |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2002723424 Country of ref document: EP |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
WWP | Wipo information: published in national office |
Ref document number: 2002723424 Country of ref document: EP |
|
WWG | Wipo information: grant in national office |
Ref document number: 2002254205 Country of ref document: AU |