WO2002078510A2 - Aluminiumimplantat und dessen verwendung - Google Patents
Aluminiumimplantat und dessen verwendung Download PDFInfo
- Publication number
- WO2002078510A2 WO2002078510A2 PCT/EP2002/003248 EP0203248W WO02078510A2 WO 2002078510 A2 WO2002078510 A2 WO 2002078510A2 EP 0203248 W EP0203248 W EP 0203248W WO 02078510 A2 WO02078510 A2 WO 02078510A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- implant
- aluminum
- barrier layer
- base material
- implant according
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/28—Surgical forceps
- A61B17/29—Forceps for use in minimally invasive surgery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/02—Inorganic materials
- A61L31/022—Metals or alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/18—Materials at least partially X-ray or laser opaque
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00831—Material properties
- A61B2017/00902—Material properties transparent or translucent
- A61B2017/00911—Material properties transparent or translucent for fields applied by a magnetic resonance imaging system
Definitions
- the present invention relates to an implant according to the preamble of claim 1 and a use of the implant.
- implant here initially means, in the narrower sense, an element that can be used at least temporarily in the body of an animal or a human being and can, for example, perform therapeutic, support and / or joint functions, such as temporary implants, for example so-called “seeds”. , or stents for tumor treatment or therapy, tracheal stents and the like. Like. To understand. In a broader sense, however, this also includes elements or the like that can be brought into contact with the body from the outside and / or in particular temporarily.
- Implants in the form of stents are used, for example, to support expanded vessels. These tubular inserts are inserted after the expansion of narrowed vessels and then expanded radially so that the stents support the inside of the vessel walls.
- Magnetic resonance - referred to here briefly as MR - is used here in particular for imaging spatial relationships in a body, for example the position of tissues, organs and / or implants, with a relatively strong magnetic field being applied and substances and due to the different magnetic properties Materials are distinguishable.
- Operations and / or examinations in which MR is used in a supportive manner, for example for control functions, or for guidance, for example for the correct positioning of an implant, are also referred to here briefly as “MR-guided and / or -based”.
- BESTATIGUNGSKOPIE In order to be able to use MR, the use of MR-compatible materials for implants is required. When using a conventional material, such as stainless steel, artifacts (misrepresentations) result in such a way that MR enables no or only inadequate (visual or spatial) resolution.
- the present invention is based on the object of specifying an implant and a use of an implant which are particularly suitable for MR-guided or -based operations and / or examinations, in particular on the human and / or animal body, but possibly also for X-ray examinations, for example by a computer tomograph, are suitable, the implant being simple and inexpensive to produce with very good mechanical properties.
- a basic idea of the invention is to use aluminum or an aluminum compound consisting primarily of aluminum or an aluminum alloy or mixtures thereof as the base material or main component.
- aluminum is surprisingly invisible or virtually invisible in an MRI scanner.
- MR magnetic resonance
- Aluminum is often used for alloys for transformer cores, i.e. for highly ferromagnetic alloys. Therefore, it is over so surprising that aluminum is suitable for the use of MR and is even particularly MR compatible.
- Aluminum has several advantages. It is available inexpensively and is easy to process, so that the proposed implant can be manufactured inexpensively. It has good mechanical properties, in particular high resilience or strength and sufficient elasticity. It is a metal that, like most metals, is very temperature-resistant, so that sterilization at elevated temperatures is possible without any problems. It is not an organic compound, so that a large number of different types of elements or ions cannot dissolve from the proposed basic material in the body with undesirable or unknown consequences.
- the base material possibly the entire implant, is covered with a barrier layer - at least in surface areas that are freely accessible and / or accessible to body fluids or tissue.
- the barrier layer is tight or impermeable to aluminum, aluminum ions and / or body fluids. This prevents aluminum ions from being released in the body that are suspected of being harmful.
- the implant is marked with a substance (marking substance) that is visible and / or MR-visible for X-rays or X-ray examinations.
- a substance marking substance
- “Marking” or “marking” is to be understood here to mean that the substance is provided in a punctiform or distributed manner in a sufficient quantity in order to make the implant visible for MR and / or X-ray examinations without the undesirable artifacts (misrepresentation or Overlaps in other areas), especially in MR.
- the marking substance such as a noble metal, heavy metal or also iron
- the marking substance is incorporated into the base material, for example, as a kind of core, in particular enveloped by it.
- the material for marking is not integrated directly into the base material, but is provided in or on the barrier layer.
- the MR-visible substance can be contained in the barrier layer material and / or can be accommodated by cavities formed in the barrier layer.
- FIG. 1 shows a schematic illustration of a proposed implant in the form of a stent
- FIG. 3 shows a further enlarged, schematic illustration of a possible layer structure according to FIG. 3;
- Fig. 4 is a schematic representation of a proposed implant in "seed" form.
- the implant 1 shows, in a perspective representation, which is greatly simplified for reasons of illustration, an implant 1 according to the proposal in the form of a stent.
- the implant 1 forms a grid-like, tubular body.
- functions and uses of the implant 1 reference is made to the definition on the input side.
- FIG. 2 shows an enlarged section of the proposed material structure of the implant 1 in a representation that is not to scale.
- the implant 1 preferably consists at least essentially of a base material 2 indicated in FIG. 2.
- FIG. 2 shows only a partial section into the material of the implant 1.
- the base material 2 is preferably covered by a barrier layer 3 on its surface, at least in surface areas 4 which are free and or accessible to body fluids or tissues.
- the base material 2 consists at least essentially of aluminum, an aluminum compound, an aluminum alloy and / or mixtures thereof. In particular from relatively pure aluminum.
- the base material 2 preferably consists of at least 95% by mass, preferably 97 or 98% by mass, of aluminum, in particular a corresponding one. Aluminum alloy. This results in the already mentioned MR compatibility of the base material 2.
- the provided barrier layer 3 is relatively thin and amorphous. This results in good or sufficient flexibility. This is particularly important when the implant 3 is designed as a stent, in order to avoid detachment of the barrier layer 3 in the interior of a vessel when the stent is usually radially expanded.
- the barrier layer 3 is preferably at least substantially uniformly thick.
- the average thickness is 10 to 200 nm, preferably 20 to 100 nm and in particular approximately 50 nm.
- the barrier layer 3 is impermeable to the base material 2, ions and / or body fluids or other body-own substances formed therefrom. In this way, an unwanted loosening of the base material 2 in the body can be prevented.
- the base material 2 is preferably plasma-coated to form the barrier layer 3, that is to say the barrier layer 3 is applied by a plasma process.
- the material to be applied here preferably silicon, is evaporated in vacuo, for example, and reacts with the addition of oxygen at the top. surface of the implant 1 with the formation of a firmly adhering oxide layer which is predominantly amorphous and thus flexible.
- the application is not limited to pure plasma processes. Rather, other methods, in particular plasma-based methods, such as the plasma-based PVD method or the plasma-based CVD method, can also be used, as in the article "Character roles" by Volker Bück and Horst Ehrich, Essener Unikate, Material Mathematics, Volume 13, (2015) GH Essen / Stuttgartsverlag, ISSN 0944-6060, page 42 following, can be used.
- plasma-based methods such as the plasma-based PVD method or the plasma-based CVD method
- the aforementioned magazine is also mentioned in its entirety as a disclosure with regard to coating processes and usable materials and also with regard to usable biocompatible materials.
- the barrier layer 3 preferably consists at least essentially of a semimetal oxide, in particular silicon dioxide.
- silicon dioxide has excellent biocompatibility and is therefore optimally tolerated by the body.
- a sufficiently dense or impermeable barrier layer 3 can also be formed with silicon dioxide.
- the barrier layer 3 Due to a relatively small thickness of the barrier layer 3, it is possible to use virtually any material for the barrier layer 3 that is in any case not MR-compatible. Due to the small total amount that is required to form the barrier layer 3, sufficient MR compatibility is maintained overall. If necessary, the barrier layer 3 can simultaneously represent a desired “marking” of the implant 1, that is to say cause the implant 1 to be used by means of MR — for example, in the case of a core spin tomography - and / or for X-rays - for example, in X-rays or computer tomography - is still visible, which is not the case when only high-purity aluminum is used.
- the barrier layer 3 can also consist of other materials, in particular at least essentially of aluminum oxide or titanium dioxide.
- a formation of aluminum oxide is appropriate, since the base material 2 - at least insofar as it is aluminum - only has to be oxidized on its surface. This is done in particular by electrolytic oxidation (anodization), a sufficiently dense or impermeable barrier layer 3 having the desired properties — sufficient flexibility, amorphous structure — being achievable.
- cavities 5 are formed in the barrier layer 3 - for example by appropriate anodization, in particular when using aluminum oxide as the material for the barrier layer 3 - to accommodate an MR-visible and / or X-ray-visible substance 6 ,
- the marking substance 6 can be formed, for example, by a metal, in particular a noble metal or a heavy metal, preferably tantalum. If necessary, the marking substance 6 can be bound to walls 8 of the cavities 5 via schematically indicated binding partners 7.
- the cavities 5 are open to the outside or surface 9 of the barrier layer 3, that is to say they have openings 10. If necessary, the openings 10 or the surface 9 can be covered by a cover layer 11, for example made of gold.
- cavities 5 are formed in the barrier layer 3, they preferably do not extend through the entire thickness of the barrier layer 3 Obtain barrier effect or barrier effect of the barrier layer 3, that is to ensure the desired impermeability.
- the marking substance 6 can also be embedded in the base material 2 and / or the barrier layer 3 in another manner, if necessary, and may be mixed with the respective material.
- the marking substance 6 can also be embedded in the base material 2 and / or the barrier layer 3 in another manner, if necessary, and may be mixed with the respective material.
- the implant 1 according to FIG. 4 is a "seed” and in particular radioactive, for example by taking a radioactive material into the cavities 5.
- the marking by the substance 6 thus enables the position of the implant 1 in the implanted state to be determined by MR and / or X-ray.
Abstract
Description
Claims
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE20220502U DE20220502U1 (de) | 2001-03-23 | 2002-03-22 | Implantat |
AU2002315263A AU2002315263A1 (en) | 2001-03-23 | 2002-03-22 | Aluminium implant and use thereof |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10114621.3 | 2001-03-23 | ||
DE10114621 | 2001-03-23 | ||
DE10123442A DE10123442C2 (de) | 2001-03-23 | 2001-05-14 | Operationswerkzeug |
DE10123442.2 | 2001-05-14 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2002078510A2 true WO2002078510A2 (de) | 2002-10-10 |
WO2002078510A3 WO2002078510A3 (de) | 2003-01-30 |
Family
ID=26008893
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2002/003248 WO2002078510A2 (de) | 2001-03-23 | 2002-03-22 | Aluminiumimplantat und dessen verwendung |
Country Status (4)
Country | Link |
---|---|
US (1) | US6697662B2 (de) |
AU (1) | AU2002315263A1 (de) |
DE (1) | DE20220502U1 (de) |
WO (1) | WO2002078510A2 (de) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10119452B4 (de) * | 2001-04-20 | 2004-02-12 | Siemens Ag | MR-kompatibles Liquorventil |
AU2002345328A1 (en) | 2001-06-27 | 2003-03-03 | Remon Medical Technologies Ltd. | Method and device for electrochemical formation of therapeutic species in vivo |
US7488343B2 (en) * | 2003-09-16 | 2009-02-10 | Boston Scientific Scimed, Inc. | Medical devices |
US8137397B2 (en) * | 2004-02-26 | 2012-03-20 | Boston Scientific Scimed, Inc. | Medical devices |
US20060231817A1 (en) * | 2005-04-14 | 2006-10-19 | Worth Willie R | Apparatus and method for center post stop debris removal |
US8840660B2 (en) | 2006-01-05 | 2014-09-23 | Boston Scientific Scimed, Inc. | Bioerodible endoprostheses and methods of making the same |
US8089029B2 (en) | 2006-02-01 | 2012-01-03 | Boston Scientific Scimed, Inc. | Bioabsorbable metal medical device and method of manufacture |
US8048150B2 (en) | 2006-04-12 | 2011-11-01 | Boston Scientific Scimed, Inc. | Endoprosthesis having a fiber meshwork disposed thereon |
EP2054537A2 (de) | 2006-08-02 | 2009-05-06 | Boston Scientific Scimed, Inc. | Endoprothese mit dreidimensionaler desintegrationssteuerung |
JP2010503494A (ja) | 2006-09-15 | 2010-02-04 | ボストン サイエンティフィック リミテッド | 生分解性内部人工器官およびその製造方法 |
WO2008034031A2 (en) | 2006-09-15 | 2008-03-20 | Boston Scientific Limited | Bioerodible endoprostheses and methods of making the same |
CA2663220A1 (en) | 2006-09-15 | 2008-03-20 | Boston Scientific Limited | Medical devices and methods of making the same |
WO2008034048A2 (en) | 2006-09-15 | 2008-03-20 | Boston Scientific Limited | Bioerodible endoprosthesis with biostable inorganic layers |
JP2010503490A (ja) | 2006-09-15 | 2010-02-04 | ボストン サイエンティフィック リミテッド | 調整可能な表面特徴を備えた内部人工器官 |
EP2068962B1 (de) | 2006-09-18 | 2013-01-30 | Boston Scientific Limited | Endoprothesen |
ES2506144T3 (es) | 2006-12-28 | 2014-10-13 | Boston Scientific Limited | Endoprótesis bioerosionables y procedimiento de fabricación de las mismas |
US8052745B2 (en) | 2007-09-13 | 2011-11-08 | Boston Scientific Scimed, Inc. | Endoprosthesis |
US7998192B2 (en) | 2008-05-09 | 2011-08-16 | Boston Scientific Scimed, Inc. | Endoprostheses |
US8236046B2 (en) | 2008-06-10 | 2012-08-07 | Boston Scientific Scimed, Inc. | Bioerodible endoprosthesis |
US7985252B2 (en) | 2008-07-30 | 2011-07-26 | Boston Scientific Scimed, Inc. | Bioerodible endoprosthesis |
US8382824B2 (en) | 2008-10-03 | 2013-02-26 | Boston Scientific Scimed, Inc. | Medical implant having NANO-crystal grains with barrier layers of metal nitrides or fluorides |
WO2010101901A2 (en) | 2009-03-02 | 2010-09-10 | Boston Scientific Scimed, Inc. | Self-buffering medical implants |
US8668732B2 (en) | 2010-03-23 | 2014-03-11 | Boston Scientific Scimed, Inc. | Surface treated bioerodible metal endoprostheses |
Citations (8)
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US4000525A (en) * | 1975-08-21 | 1977-01-04 | The United States Of America As Represented By The Secretary Of The Navy | Ceramic prosthetic implant suitable for a knee joint plateau |
DE3101679A1 (de) * | 1980-01-21 | 1981-12-17 | Shin-Etsu Chemical Co., Ltd., Tokyo | Alloplastische prothese und deren verwendung |
EP0231838A2 (de) * | 1986-01-30 | 1987-08-12 | Feldmühle Aktiengesellschaft | Zahnimplantat |
DE19506188A1 (de) * | 1995-02-22 | 1996-08-29 | Miladin Dr Lazarov | Implantat |
DE29804531U1 (de) * | 1998-03-13 | 1998-05-20 | Aesculap Ag & Co Kg | Chirurgisches Instrument |
EP0982041A1 (de) * | 1998-08-21 | 2000-03-01 | Medtronic Ave, Inc. | Gerinnungsbeständige Beschichtung auf der Basis von Silanen oder Siloxanen |
DE19855421A1 (de) * | 1998-11-02 | 2000-05-11 | Wolfgang Brandau | Implantat |
DE19858579A1 (de) * | 1998-12-18 | 2000-06-21 | Aesculap Ag & Co Kg | Implantat |
Family Cites Families (13)
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US5096558A (en) | 1984-04-12 | 1992-03-17 | Plasco Dr. Ehrich Plasma - Coating Gmbh | Method and apparatus for evaporating material in vacuum |
DE3413891A1 (de) | 1984-04-12 | 1985-10-17 | Horst Dipl.-Phys. Dr. 4270 Dorsten Ehrich | Verfahren und vorrichtung zum verdampfen von material in vakuum |
DD282180A5 (de) | 1989-03-03 | 1990-09-05 | Univ Schiller Jena | Verfahren zur herstellung bioaktiver und mechanisch hoch belastbarer implantate |
DE4012048A1 (de) | 1990-04-13 | 1991-10-17 | Berchem & Schaberg Gmbh | Metallimplantat fuer medizinische zwecke |
US5342283A (en) * | 1990-08-13 | 1994-08-30 | Good Roger R | Endocurietherapy |
DE4200429A1 (de) | 1992-01-10 | 1993-07-15 | Ehrich Plasma Coating | Verfahren zur ionisation thermisch erzeugter materialdaempfe und vorrichtung zur durchfuehrung des verfahrens |
US5565248A (en) | 1994-02-09 | 1996-10-15 | The Coca-Cola Company | Method and apparatus for coating hollow containers through plasma-assisted deposition of an inorganic substance |
US6333971B2 (en) * | 1995-06-07 | 2001-12-25 | George S. Allen | Fiducial marker |
US5744958A (en) * | 1995-11-07 | 1998-04-28 | Iti Medical Technologies, Inc. | Instrument having ultra-thin conductive coating and method for magnetic resonance imaging of such instrument |
US6045497A (en) * | 1997-01-02 | 2000-04-04 | Myocor, Inc. | Heart wall tension reduction apparatus and method |
DE19858578C2 (de) | 1998-12-18 | 2001-01-04 | Aesculap Ag & Co Kg | Chirurgisches Instrument |
DE19948783C2 (de) | 1999-02-18 | 2001-06-13 | Alcove Surfaces Gmbh | Implantat |
US6447443B1 (en) * | 2001-01-13 | 2002-09-10 | Medtronic, Inc. | Method for organ positioning and stabilization |
-
2002
- 2002-03-22 WO PCT/EP2002/003248 patent/WO2002078510A2/de not_active Application Discontinuation
- 2002-03-22 AU AU2002315263A patent/AU2002315263A1/en not_active Abandoned
- 2002-03-22 US US10/103,570 patent/US6697662B2/en not_active Expired - Fee Related
- 2002-03-22 DE DE20220502U patent/DE20220502U1/de not_active Expired - Lifetime
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4000525A (en) * | 1975-08-21 | 1977-01-04 | The United States Of America As Represented By The Secretary Of The Navy | Ceramic prosthetic implant suitable for a knee joint plateau |
DE3101679A1 (de) * | 1980-01-21 | 1981-12-17 | Shin-Etsu Chemical Co., Ltd., Tokyo | Alloplastische prothese und deren verwendung |
EP0231838A2 (de) * | 1986-01-30 | 1987-08-12 | Feldmühle Aktiengesellschaft | Zahnimplantat |
DE19506188A1 (de) * | 1995-02-22 | 1996-08-29 | Miladin Dr Lazarov | Implantat |
DE29804531U1 (de) * | 1998-03-13 | 1998-05-20 | Aesculap Ag & Co Kg | Chirurgisches Instrument |
EP0982041A1 (de) * | 1998-08-21 | 2000-03-01 | Medtronic Ave, Inc. | Gerinnungsbeständige Beschichtung auf der Basis von Silanen oder Siloxanen |
DE19855421A1 (de) * | 1998-11-02 | 2000-05-11 | Wolfgang Brandau | Implantat |
DE19858579A1 (de) * | 1998-12-18 | 2000-06-21 | Aesculap Ag & Co Kg | Implantat |
Also Published As
Publication number | Publication date |
---|---|
AU2002315263A1 (en) | 2002-10-15 |
WO2002078510A3 (de) | 2003-01-30 |
DE20220502U1 (de) | 2003-10-02 |
US6697662B2 (en) | 2004-02-24 |
US20020165578A1 (en) | 2002-11-07 |
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