WO2002078675A3 - Particles for inhalation having sustained release properties - Google Patents

Particles for inhalation having sustained release properties Download PDF

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Publication number
WO2002078675A3
WO2002078675A3 PCT/US2002/009697 US0209697W WO02078675A3 WO 2002078675 A3 WO2002078675 A3 WO 2002078675A3 US 0209697 W US0209697 W US 0209697W WO 02078675 A3 WO02078675 A3 WO 02078675A3
Authority
WO
WIPO (PCT)
Prior art keywords
agent
particles
diagnostic
prophylactic
therapeutic
Prior art date
Application number
PCT/US2002/009697
Other languages
French (fr)
Other versions
WO2002078675A2 (en
Inventor
David A Edwards
Jeffrey S Hrkach
Original Assignee
Advanced Inhalation Res Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advanced Inhalation Res Inc filed Critical Advanced Inhalation Res Inc
Publication of WO2002078675A2 publication Critical patent/WO2002078675A2/en
Publication of WO2002078675A3 publication Critical patent/WO2002078675A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds

Abstract

The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in sustained fashion, and to particles suitable for use in the method. In particular, the invention relates to a method for the pulmonary delivery of a therapeutic, prophylactic or diagnostic agent comprising administering to the respiratory tract of a patient in need of treatment, prophylaxis or diagnostic and effective amount of particles comprising a multivalent metal cation which is complexed with a therapeutic, prophylactic or diagnostic agent of any combination thereof having a charge capable of complexing with the cation upon association with the agent, a pharmaceutically acceptable carrier and optionally, a multivalent metal cation-containing component wherein the total amount of multivalent metal cation present in the particles is more than 1% weight/weight of the total weight of the agent (%w/w). Release of the agent from the administrated particles occurs in a sustained fashion.
PCT/US2002/009697 2001-03-30 2002-03-27 Particles for inhalation having sustained release properties WO2002078675A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/822,716 2001-03-30
US09/822,716 US7678364B2 (en) 1999-08-25 2001-03-30 Particles for inhalation having sustained release properties

Publications (2)

Publication Number Publication Date
WO2002078675A2 WO2002078675A2 (en) 2002-10-10
WO2002078675A3 true WO2002078675A3 (en) 2002-11-28

Family

ID=25236771

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/009697 WO2002078675A2 (en) 2001-03-30 2002-03-27 Particles for inhalation having sustained release properties

Country Status (2)

Country Link
US (1) US7678364B2 (en)
WO (1) WO2002078675A2 (en)

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