WO2002081729A2 - Nucleic acid amplification utilizing microfluidic devices - Google Patents
Nucleic acid amplification utilizing microfluidic devices Download PDFInfo
- Publication number
- WO2002081729A2 WO2002081729A2 PCT/US2002/010815 US0210815W WO02081729A2 WO 2002081729 A2 WO2002081729 A2 WO 2002081729A2 US 0210815 W US0210815 W US 0210815W WO 02081729 A2 WO02081729 A2 WO 02081729A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- temperature
- flow channel
- sample
- microfluidic device
- flow channels
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/50—Circulation mixers, e.g. wherein at least part of the mixture is discharged from and reintroduced into a receptacle
- B01F25/51—Circulation mixers, e.g. wherein at least part of the mixture is discharged from and reintroduced into a receptacle in which the mixture is circulated through a set of tubes, e.g. with gradual introduction of a component into the circulating flow
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/50—Circulation mixers, e.g. wherein at least part of the mixture is discharged from and reintroduced into a receptacle
- B01F25/54—Circulation mixers, e.g. wherein at least part of the mixture is discharged from and reintroduced into a receptacle provided with a pump inside the receptacle to recirculate the material within the receptacle
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
- B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
- B01L7/525—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples with physical movement of samples between temperature zones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q3/00—Condition responsive control processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/90—Heating or cooling systems
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/088—Channel loops
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0883—Serpentine channels
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0887—Laminated structure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/12—Specific details about materials
- B01L2300/123—Flexible; Elastomeric
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
- B01L2300/1822—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using Peltier elements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
- B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1838—Means for temperature control using fluid heat transfer medium
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0633—Valves, specific forms thereof with moving parts
- B01L2400/0655—Valves, specific forms thereof with moving parts pinch valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L9/00—Supporting devices; Holding devices
- B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
- B01L9/527—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
Abstract
Description
Claims
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2002307152A AU2002307152A1 (en) | 2001-04-06 | 2002-04-05 | Nucleic acid amplification utilizing microfluidic devices |
EP02763966A EP1384022A4 (en) | 2001-04-06 | 2002-04-05 | Nucleic acid amplification utilizing microfluidic devices |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28196001P | 2001-04-06 | 2001-04-06 | |
US60/281,960 | 2001-04-06 | ||
US30051601P | 2001-06-22 | 2001-06-22 | |
US60/300,516 | 2001-06-22 | ||
US33447301P | 2001-11-16 | 2001-11-16 | |
US60/334,473 | 2001-11-16 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2002081729A2 true WO2002081729A2 (en) | 2002-10-17 |
WO2002081729A3 WO2002081729A3 (en) | 2002-12-05 |
Family
ID=27403264
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2002/010815 WO2002081729A2 (en) | 2001-04-06 | 2002-04-05 | Nucleic acid amplification utilizing microfluidic devices |
Country Status (4)
Country | Link |
---|---|
US (4) | US6960437B2 (en) |
EP (1) | EP1384022A4 (en) |
AU (1) | AU2002307152A1 (en) |
WO (1) | WO2002081729A2 (en) |
Cited By (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003042410A1 (en) * | 2001-11-10 | 2003-05-22 | Samsung Electronics Co., Ltd. | Apparatus for circulating carrier fluid |
EP1464399A2 (en) * | 2003-04-02 | 2004-10-06 | Hitachi, Ltd. | Nucleic-acid amplifying apparatus and nucleic-acid amplifying method |
WO2005094981A1 (en) * | 2004-03-29 | 2005-10-13 | Agilent Technologies, Inc. | Cyclic pcr system |
GB2433259A (en) * | 2005-11-30 | 2007-06-20 | Deltadot Ltd | Nucleic acid amplification method and microfluidic apparatus therefore |
US7307802B2 (en) | 2004-06-07 | 2007-12-11 | Fluidigm Corporation | Optical lens system and method for microfluidic devices |
WO2008154036A1 (en) | 2007-06-11 | 2008-12-18 | Wako Pure Chemical Industries, Ltd. | Microchip large-volume pcr with integrated real-time ce detection |
EP2008717A2 (en) | 2007-06-28 | 2008-12-31 | Sony Corporation | Reaction device with accurate temperature control |
GB2452057A (en) * | 2007-08-23 | 2009-02-25 | Shaw Stewart P D | A microfluidic device for thermal assays |
USRE41780E1 (en) | 2003-03-14 | 2010-09-28 | Lawrence Livermore National Security, Llc | Chemical amplification based on fluid partitioning in an immiscible liquid |
US7815868B1 (en) | 2006-02-28 | 2010-10-19 | Fluidigm Corporation | Microfluidic reaction apparatus for high throughput screening |
US7820427B2 (en) | 2001-11-30 | 2010-10-26 | Fluidigm Corporation | Microfluidic device and methods of using same |
US7833708B2 (en) | 2001-04-06 | 2010-11-16 | California Institute Of Technology | Nucleic acid amplification using microfluidic devices |
US7887753B2 (en) | 2000-11-16 | 2011-02-15 | California Institute Of Technology | Apparatus and methods for conducting assays and high throughput screening |
EP2286247A2 (en) * | 2008-04-23 | 2011-02-23 | Bioscale, Inc. | Method and apparatus for analyte processing |
EP2285491A1 (en) * | 2008-04-25 | 2011-02-23 | Claros Diagnostics, Inc. | Flow control in microfluidic systems |
WO2011045288A2 (en) | 2009-10-13 | 2011-04-21 | Iti Scotland Limited | Microfluidic mixer |
JP2013503605A (en) * | 2009-09-01 | 2013-02-04 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | Devices and methods for microarray selection |
WO2013166857A1 (en) | 2012-05-07 | 2013-11-14 | Capitalbio Corporation | Microfluidic devices for multi-index biochemical detection |
US8632973B2 (en) | 2004-05-13 | 2014-01-21 | Nanobiosym, Inc. | Nano-PCR: methods and devices for nucleic acid amplification and detection |
US8658418B2 (en) | 2002-04-01 | 2014-02-25 | Fluidigm Corporation | Microfluidic particle-analysis systems |
CN103952288A (en) * | 2009-04-02 | 2014-07-30 | 弗卢伊蒂格姆公司 | Multi-primer amplification method for barcoding of target nucleic acids |
US8871446B2 (en) | 2002-10-02 | 2014-10-28 | California Institute Of Technology | Microfluidic nucleic acid analysis |
US9074204B2 (en) | 2011-05-20 | 2015-07-07 | Fluidigm Corporation | Nucleic acid encoding reactions |
US9089844B2 (en) | 2010-11-01 | 2015-07-28 | Bio-Rad Laboratories, Inc. | System for forming emulsions |
US9101933B2 (en) | 2008-10-10 | 2015-08-11 | University Of Hull | Microfluidic apparatus and method for DNA extraction, amplification and analysis |
WO2015162060A1 (en) * | 2014-04-25 | 2015-10-29 | Robert Bosch Gmbh | Microfluidic device and method for analysing a sample of biological material |
WO2016008822A3 (en) * | 2014-07-16 | 2016-05-19 | Technische Universität Dresden | Method for identifying high-affinity complexes of two ligands and a receptor, device for carrying out the method and self-assemblying chemical library for use with said method |
EP1796824A4 (en) * | 2004-05-02 | 2016-10-19 | Fluidigm Corp | Thermal reaction device and method for using the same |
US9492797B2 (en) | 2008-09-23 | 2016-11-15 | Bio-Rad Laboratories, Inc. | System for detection of spaced droplets |
US9623384B2 (en) | 2008-09-23 | 2017-04-18 | Bio-Rad Laboratories, Inc. | System for transporting emulsions from an array to a detector |
EP3181229A1 (en) * | 2015-12-17 | 2017-06-21 | Euroimmun Medizinische Labordiagnostika AG | Analytical device for carrying out a pcr reaction |
US9714443B2 (en) | 2002-09-25 | 2017-07-25 | California Institute Of Technology | Microfabricated structure having parallel and orthogonal flow channels controlled by row and column multiplexors |
US9764322B2 (en) | 2008-09-23 | 2017-09-19 | Bio-Rad Laboratories, Inc. | System for generating droplets with pressure monitoring |
EP3051293A4 (en) * | 2013-09-25 | 2017-11-22 | The University of Tokyo | Solution mixer, fluid device, and solution mixing method |
US9840732B2 (en) | 2012-05-21 | 2017-12-12 | Fluidigm Corporation | Single-particle analysis of particle populations |
US9862984B2 (en) | 2006-04-21 | 2018-01-09 | Nanobiosym, Inc. | Single-molecule platform for drug discovery: methods and apparatuses for drug discovery, including discovery of anticancer and antiviral agents |
US9885034B2 (en) | 2011-04-25 | 2018-02-06 | Bio-Rad Laboratories, Inc. | Methods and compositions for nucleic acid analysis |
WO2018065102A1 (en) * | 2016-10-07 | 2018-04-12 | Boehringer Ingelheim Vetmedica Gmbh | Method and analysis system for testing a sample |
CN108541225A (en) * | 2016-01-08 | 2018-09-14 | 高丽大学校产学协力团 | Instant nucleic acid amplification measuring device based on surface measurement sensing |
US10099219B2 (en) | 2010-03-25 | 2018-10-16 | Bio-Rad Laboratories, Inc. | Device for generating droplets |
US10131934B2 (en) | 2003-04-03 | 2018-11-20 | Fluidigm Corporation | Thermal reaction device and method for using the same |
US10166522B2 (en) | 2009-09-02 | 2019-01-01 | Bio-Rad Laboratories, Inc. | System for mixing fluids by coalescence of multiple emulsions |
US10378048B2 (en) | 2010-03-02 | 2019-08-13 | Bio-Rad Laboratories, Inc. | Emulsion chemistry for encapsulated droplets |
US10512910B2 (en) | 2008-09-23 | 2019-12-24 | Bio-Rad Laboratories, Inc. | Droplet-based analysis method |
US10590386B2 (en) | 2010-06-13 | 2020-03-17 | Insitute Of Biophysics, Chinese Academy Of Sciences | Methods and compositions for preparing cardiomyocytes from stem cells and uses thereof |
US10933417B2 (en) | 2013-03-15 | 2021-03-02 | Nanobiosym, Inc. | Systems and methods for mobile device analysis of nucleic acids and proteins |
US11117113B2 (en) | 2015-12-16 | 2021-09-14 | Fluidigm Corporation | High-level multiplex amplification |
US11130128B2 (en) | 2008-09-23 | 2021-09-28 | Bio-Rad Laboratories, Inc. | Detection method for a target nucleic acid |
US11192106B2 (en) | 2016-06-06 | 2021-12-07 | Nikon Corporation | Fluidic device, system, method of detecting sample material and method of purifying sample material |
US11339371B2 (en) | 2012-07-23 | 2022-05-24 | Institute Of Biophysics, Chinese Academy Of Sciences | Method for inducing pluripotent stem cells to differentiate into ventricular myocytes in vitro |
Families Citing this family (463)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6221654B1 (en) | 1996-09-25 | 2001-04-24 | California Institute Of Technology | Method and apparatus for analysis and sorting of polynucleotides based on size |
US6833242B2 (en) * | 1997-09-23 | 2004-12-21 | California Institute Of Technology | Methods for detecting and sorting polynucleotides based on size |
US7306672B2 (en) | 2001-04-06 | 2007-12-11 | California Institute Of Technology | Microfluidic free interface diffusion techniques |
US7459022B2 (en) | 2001-04-06 | 2008-12-02 | California Institute Of Technology | Microfluidic protein crystallography |
US7217321B2 (en) | 2001-04-06 | 2007-05-15 | California Institute Of Technology | Microfluidic protein crystallography techniques |
US7144616B1 (en) | 1999-06-28 | 2006-12-05 | California Institute Of Technology | Microfabricated elastomeric valve and pump systems |
US7244402B2 (en) * | 2001-04-06 | 2007-07-17 | California Institute Of Technology | Microfluidic protein crystallography |
US7195670B2 (en) * | 2000-06-27 | 2007-03-27 | California Institute Of Technology | High throughput screening of crystallization of materials |
US7601270B1 (en) * | 1999-06-28 | 2009-10-13 | California Institute Of Technology | Microfabricated elastomeric valve and pump systems |
US8709153B2 (en) | 1999-06-28 | 2014-04-29 | California Institute Of Technology | Microfludic protein crystallography techniques |
US7052545B2 (en) * | 2001-04-06 | 2006-05-30 | California Institute Of Technology | High throughput screening of crystallization of materials |
CA2290731A1 (en) * | 1999-11-26 | 2001-05-26 | D. Jed Harrison | Apparatus and method for trapping bead based reagents within microfluidic analysis system |
US6432290B1 (en) | 1999-11-26 | 2002-08-13 | The Governors Of The University Of Alberta | Apparatus and method for trapping bead based reagents within microfluidic analysis systems |
US7485454B1 (en) * | 2000-03-10 | 2009-02-03 | Bioprocessors Corp. | Microreactor |
US7867763B2 (en) * | 2004-01-25 | 2011-01-11 | Fluidigm Corporation | Integrated chip carriers with thermocycler interfaces and methods of using the same |
US20050118073A1 (en) | 2003-11-26 | 2005-06-02 | Fluidigm Corporation | Devices and methods for holding microfluidic devices |
US7351376B1 (en) | 2000-06-05 | 2008-04-01 | California Institute Of Technology | Integrated active flux microfluidic devices and methods |
AU2001273057A1 (en) * | 2000-06-27 | 2002-01-08 | Fluidigm Corporation | A microfluidic design automation method and system |
AU2001290879A1 (en) | 2000-09-15 | 2002-03-26 | California Institute Of Technology | Microfabricated crossflow devices and methods |
EP1336097A4 (en) * | 2000-10-13 | 2006-02-01 | Fluidigm Corp | Microfluidic device based sample injection system for analytical devices |
US8900811B2 (en) * | 2000-11-16 | 2014-12-02 | Caliper Life Sciences, Inc. | Method and apparatus for generating thermal melting curves in a microfluidic device |
EP1354064A2 (en) | 2000-12-01 | 2003-10-22 | Visigen Biotechnologies, Inc. | Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity |
US6692700B2 (en) | 2001-02-14 | 2004-02-17 | Handylab, Inc. | Heat-reduction methods and systems related to microfluidic devices |
WO2002072264A1 (en) * | 2001-03-09 | 2002-09-19 | Biomicro Systems, Inc. | Method and system for microfluidic interfacing to arrays |
US8895311B1 (en) | 2001-03-28 | 2014-11-25 | Handylab, Inc. | Methods and systems for control of general purpose microfluidic devices |
US7829025B2 (en) | 2001-03-28 | 2010-11-09 | Venture Lending & Leasing Iv, Inc. | Systems and methods for thermal actuation of microfluidic devices |
JP2004527247A (en) * | 2001-04-10 | 2004-09-09 | バイオプロセッサーズ コーポレイション | Microfermentor devices and cell-based screening methods |
US20040132166A1 (en) * | 2001-04-10 | 2004-07-08 | Bioprocessors Corp. | Determination and/or control of reactor environmental conditions |
US20040058407A1 (en) * | 2001-04-10 | 2004-03-25 | Miller Scott E. | Reactor systems having a light-interacting component |
US20040058437A1 (en) * | 2001-04-10 | 2004-03-25 | Rodgers Seth T. | Materials and reactor systems having humidity and gas control |
US20050032204A1 (en) * | 2001-04-10 | 2005-02-10 | Bioprocessors Corp. | Microreactor architecture and methods |
KR100421359B1 (en) * | 2001-07-24 | 2004-03-06 | 엘지전자 주식회사 | Method for delivering fluid in elastic substrate and device for it |
US8440093B1 (en) | 2001-10-26 | 2013-05-14 | Fuidigm Corporation | Methods and devices for electronic and magnetic sensing of the contents of microfluidic flow channels |
US7691333B2 (en) * | 2001-11-30 | 2010-04-06 | Fluidigm Corporation | Microfluidic device and methods of using same |
US7312085B2 (en) * | 2002-04-01 | 2007-12-25 | Fluidigm Corporation | Microfluidic particle-analysis systems |
US20050026134A1 (en) * | 2002-04-10 | 2005-02-03 | Bioprocessors Corp. | Systems and methods for control of pH and other reactor environment conditions |
AUPS267702A0 (en) * | 2002-05-30 | 2002-06-20 | Corbett Research Pty Ltd | Optical means for calibrating temperature |
US20050106714A1 (en) * | 2002-06-05 | 2005-05-19 | Zarur Andrey J. | Rotatable reactor systems and methods |
US8168139B2 (en) * | 2002-06-24 | 2012-05-01 | Fluidigm Corporation | Recirculating fluidic network and methods for using the same |
US7329545B2 (en) | 2002-09-24 | 2008-02-12 | Duke University | Methods for sampling a liquid flow |
US6911132B2 (en) | 2002-09-24 | 2005-06-28 | Duke University | Apparatus for manipulating droplets by electrowetting-based techniques |
US8220494B2 (en) | 2002-09-25 | 2012-07-17 | California Institute Of Technology | Microfluidic large scale integration |
US20050089875A1 (en) * | 2002-11-21 | 2005-04-28 | Sention Inc. | Quantitative analysis of expression profiling information produced at various stages of an amplification process |
CA2510166A1 (en) | 2002-12-20 | 2004-09-30 | Caliper Life Sciences, Inc. | Single molecule amplification and detection of dna |
WO2004061085A2 (en) * | 2002-12-30 | 2004-07-22 | The Regents Of The University Of California | Methods and apparatus for pathogen detection and analysis |
JPWO2004068144A1 (en) * | 2003-01-31 | 2006-05-25 | ユニバーサル・バイオ・リサーチ株式会社 | Method and apparatus for analyzing liquid sample |
GB0304033D0 (en) * | 2003-02-21 | 2003-03-26 | Imp College Innovations Ltd | Apparatus |
CN100439515C (en) * | 2003-03-03 | 2008-12-03 | 清华大学 | Laboratory nucleic acid analyzing chip system and its application |
US10533998B2 (en) | 2008-07-18 | 2020-01-14 | Bio-Rad Laboratories, Inc. | Enzyme quantification |
GB0307428D0 (en) | 2003-03-31 | 2003-05-07 | Medical Res Council | Compartmentalised combinatorial chemistry |
US20060078893A1 (en) | 2004-10-12 | 2006-04-13 | Medical Research Council | Compartmentalised combinatorial chemistry by microfluidic control |
GB0307403D0 (en) | 2003-03-31 | 2003-05-07 | Medical Res Council | Selection by compartmentalised screening |
DE10315074A1 (en) * | 2003-04-02 | 2004-10-14 | Clondiag Chip Technologies Gmbh | Device for the duplication and detection of nucleic acids |
US20050145496A1 (en) | 2003-04-03 | 2005-07-07 | Federico Goodsaid | Thermal reaction device and method for using the same |
US7476363B2 (en) * | 2003-04-03 | 2009-01-13 | Fluidigm Corporation | Microfluidic devices and methods of using same |
US8828663B2 (en) * | 2005-03-18 | 2014-09-09 | Fluidigm Corporation | Thermal reaction device and method for using the same |
AU2004228678A1 (en) * | 2003-04-03 | 2004-10-21 | Fluidigm Corp. | Microfluidic devices and methods of using same |
CN1280428C (en) * | 2003-05-19 | 2006-10-18 | 清华大学 | Biochip system based on minute particle and its application |
WO2004103563A2 (en) | 2003-05-20 | 2004-12-02 | Fluidigm Corporation | Method and system for microfluidic device and imaging thereof |
DE04752947T1 (en) | 2003-05-23 | 2006-11-16 | Bio-Rad Laboratories, Inc., Hercules | LOCALIZED TEMPERATURE CONTROL FOR ROOM ARRANGEMENTS OF REACTION MEDIA |
US20050026273A1 (en) * | 2003-06-05 | 2005-02-03 | Zarur Andrey J. | Reactor with memory component |
US7648835B2 (en) * | 2003-06-06 | 2010-01-19 | Micronics, Inc. | System and method for heating, cooling and heat cycling on microfluidic device |
CN1812839A (en) * | 2003-06-06 | 2006-08-02 | 精密公司 | System and method for heating, cooling and heat cycling on microfluidic device |
EP1649056A1 (en) * | 2003-07-02 | 2006-04-26 | Caliper Life Sciences, Inc. | Methods for amplifying and detecting nucleic acids in microfluidic devices under continuous and non-continuous flow conditions. |
WO2005011947A2 (en) | 2003-07-28 | 2005-02-10 | Fluidigm Corporation | Image processing method and system for microfluidic devices |
EP2402089A1 (en) | 2003-07-31 | 2012-01-04 | Handylab, Inc. | Processing particle-containing samples |
US7413712B2 (en) * | 2003-08-11 | 2008-08-19 | California Institute Of Technology | Microfluidic rotary flow reactor matrix |
DE10361927B4 (en) * | 2003-12-19 | 2006-12-14 | Technische Universität Dresden | Ion channel sensor array |
US7407799B2 (en) | 2004-01-16 | 2008-08-05 | California Institute Of Technology | Microfluidic chemostat |
CA2554240A1 (en) * | 2004-01-25 | 2005-08-11 | Fluidigm Corporation | Crystal forming devices and systems and methods for making and using the same |
AU2004315186B2 (en) * | 2004-02-03 | 2008-03-13 | Bioneer Corporation | High throughput device for performing continuous-flow reactions |
JP2005278480A (en) * | 2004-03-29 | 2005-10-13 | Fujitsu Ltd | Device for introducing material and tip for introducing material |
US20050221339A1 (en) | 2004-03-31 | 2005-10-06 | Medical Research Council Harvard University | Compartmentalised screening by microfluidic control |
US20180243741A1 (en) * | 2004-05-02 | 2018-08-30 | Fluidigm Corporation | Thermal reaction device and method for using the same |
US8852862B2 (en) | 2004-05-03 | 2014-10-07 | Handylab, Inc. | Method for processing polynucleotide-containing samples |
US8916348B2 (en) * | 2004-05-06 | 2014-12-23 | Clondiag Gmbh | Method and device for the detection of molecular interactions |
US7694694B2 (en) * | 2004-05-10 | 2010-04-13 | The Aerospace Corporation | Phase-change valve apparatuses |
US8642353B2 (en) * | 2004-05-10 | 2014-02-04 | The Aerospace Corporation | Microfluidic device for inducing separations by freezing and associated method |
US7799553B2 (en) | 2004-06-01 | 2010-09-21 | The Regents Of The University Of California | Microfabricated integrated DNA analysis system |
US20050282130A1 (en) * | 2004-06-01 | 2005-12-22 | Fuji Photo Film Co., Ltd. | Method for experiment using scientific phenomenon evaluation apparatus, and scientific phenomenon evaluation apparatus |
WO2005118138A1 (en) * | 2004-06-04 | 2005-12-15 | Crystal Vision Microsystems Llc | Device and process for continuous on-chip flow injection analysis |
EP1765487A1 (en) * | 2004-06-07 | 2007-03-28 | Bioprocessors Corporation | Reactor mixing |
WO2005121307A2 (en) * | 2004-06-07 | 2005-12-22 | Bioprocessor Corp. | Gas control in a microreactor |
JP2008501365A (en) * | 2004-06-07 | 2008-01-24 | バイオプロセッサーズ コーポレイション | Generation of shear force in the reactor |
EP1761331A2 (en) * | 2004-06-07 | 2007-03-14 | Bioprocessors Corporation | Control of reactor environmental conditions |
US7121998B1 (en) * | 2004-06-08 | 2006-10-17 | Eurica Califorrniaa | Vented microcradle for prenidial incubator |
US7650910B2 (en) * | 2004-06-24 | 2010-01-26 | The Aerospace Corporation | Electro-hydraulic valve apparatuses |
US7721762B2 (en) * | 2004-06-24 | 2010-05-25 | The Aerospace Corporation | Fast acting valve apparatuses |
US7686040B2 (en) * | 2004-06-24 | 2010-03-30 | The Aerospace Corporation | Electro-hydraulic devices |
EP1784505B1 (en) * | 2004-09-02 | 2016-06-22 | Bioneer Corporation | Miniaturized apparatus for real-time monitoring |
EP1794581A2 (en) * | 2004-09-15 | 2007-06-13 | Microchip Biotechnologies, Inc. | Microfluidic devices |
US7968287B2 (en) | 2004-10-08 | 2011-06-28 | Medical Research Council Harvard University | In vitro evolution in microfluidic systems |
JP4999103B2 (en) | 2004-10-27 | 2012-08-15 | セフィード | Multistage nucleic acid amplification reaction in closed system |
JP2008522795A (en) * | 2004-12-03 | 2008-07-03 | カリフォルニア インスティチュート オブ テクノロジー | Microfluidic device with chemical reaction circuit |
US20080264863A1 (en) * | 2004-12-03 | 2008-10-30 | California Institute Of Technology | Microfluidic Sieve Valves |
NZ537147A (en) * | 2004-12-13 | 2007-06-29 | Australo Ltd | Method and apparatus for particle analysis |
KR100682920B1 (en) * | 2005-01-20 | 2007-02-15 | 삼성전자주식회사 | Microfluidic chip for multiple bioassay and its method for production |
CN101146595B (en) | 2005-01-28 | 2012-07-04 | 杜克大学 | Apparatuses and methods for manipulating droplets on a printed circuit board |
EP1861512A4 (en) * | 2005-03-18 | 2009-12-09 | Fluidigm Corp | Thermal reaction device and method for using the same |
JP4517921B2 (en) * | 2005-03-31 | 2010-08-04 | ソニー株式会社 | Biological reaction execution device and biological reaction execution method, information processing device and information processing method, program, and recording medium |
WO2006106643A1 (en) * | 2005-04-01 | 2006-10-12 | Konica Minolta Medical & Graphic, Inc. | Micro overall analysis system, inspection chip, and inspection method |
WO2006127191A2 (en) | 2005-04-20 | 2006-11-30 | Fluidigm Corporation | Analysis engine and database for manipulating parameters for fluidic systems on a chip |
AU2012200153B2 (en) * | 2005-05-09 | 2012-09-27 | Biofire Diagnostics, Llc | Self-Contained Biological Analysis |
CA2607661C (en) * | 2005-05-09 | 2017-08-08 | Idaho Technology, Inc. | A device and method for two-stage nucleic acid amplification |
AU2006247752B2 (en) | 2005-05-11 | 2012-04-12 | Advanced Liquid Logic, Inc. | Method and device for conducting biochemical or chemical reactions at multiple temperatures |
WO2007044091A2 (en) | 2005-06-02 | 2007-04-19 | Fluidigm Corporation | Analysis using microfluidic partitioning devices |
TWI271435B (en) * | 2005-06-29 | 2007-01-21 | Univ Nat Cheng Kung | Polymerare Chain Reaction chip |
JP5049274B2 (en) * | 2005-06-30 | 2012-10-17 | ビオカルティ ソシエテ アノニム | Cartridge for automated medical diagnosis |
US9376658B2 (en) * | 2008-01-03 | 2016-06-28 | Emd Millipore Corporation | Cell culture array system for automated assays and methods of operation and manufacture thereof |
US9388374B2 (en) | 2005-07-07 | 2016-07-12 | Emd Millipore Corporation | Microfluidic cell culture systems |
US8257964B2 (en) | 2006-01-04 | 2012-09-04 | Cell ASIC | Microwell cell-culture device and fabrication method |
EP3029135B1 (en) | 2005-07-07 | 2021-03-17 | The Regents of the University of California | Apparatus for cell culture array |
US9637715B2 (en) | 2005-07-07 | 2017-05-02 | Emd Millipore Corporation | Cell culture and invasion assay method and system |
US9354156B2 (en) * | 2007-02-08 | 2016-05-31 | Emd Millipore Corporation | Microfluidic particle analysis method, device and system |
KR20080027392A (en) * | 2005-07-14 | 2008-03-26 | 나노디텍 코포레이션 | Microfluidic devices and methods of preparing and using the same |
WO2007021814A2 (en) * | 2005-08-11 | 2007-02-22 | Eksigent Technologies, Llc | Plastic surfaces and apparatuses for reduced adsorption of solutes and methods of preparing the same |
US20070054293A1 (en) * | 2005-08-30 | 2007-03-08 | California Institute Of Technology | Microfluidic chaotic mixing systems and methods |
JP2007078393A (en) * | 2005-09-12 | 2007-03-29 | Yamaha Corp | Microchip |
EP1938101A2 (en) * | 2005-09-13 | 2008-07-02 | Fluidigm Corporation | Microfluidic assay devices and methods |
ATE548112T1 (en) * | 2005-09-29 | 2012-03-15 | Siemens Medical Solutions | MICROFLUIDIIC CHIP CAPABILITY OF SYNTHESIS OF RADIOACTIVE LABELED MOLECULES ON A SCALE SUITABLE FOR HUMAN IMAGING USING POSITRON EMISSION TOPOGRAPHY |
US8263022B2 (en) | 2005-10-04 | 2012-09-11 | Headway Technologies, Inc. | Microfluidic detection of analytes |
EP1946057B1 (en) * | 2005-10-31 | 2017-10-11 | Senzime AB (publ.) | A biosensor apparatus for detection of thermal flow |
US20090165876A1 (en) * | 2005-11-22 | 2009-07-02 | Micah James Atkin | Microfluidic Structures |
US8068991B2 (en) | 2005-11-30 | 2011-11-29 | The Invention Science Fund I, Llc | Systems and methods for transmitting pathogen related information and responding |
US20080241935A1 (en) | 2007-03-27 | 2008-10-02 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Methods for pathogen detection |
KR101157176B1 (en) * | 2005-12-20 | 2012-06-20 | 삼성전자주식회사 | Microfluidic device and method for concentration or purification of cells or viruses |
US8703445B2 (en) * | 2005-12-29 | 2014-04-22 | Abbott Point Of Care Inc. | Molecular diagnostics amplification system and methods |
WO2007081386A2 (en) | 2006-01-11 | 2007-07-19 | Raindance Technologies, Inc. | Microfluidic devices and methods of use |
EP1987358A4 (en) * | 2006-01-26 | 2013-12-04 | California Inst Of Techn | Mechanically induced trapping of molecular interactions |
US7749365B2 (en) | 2006-02-01 | 2010-07-06 | IntegenX, Inc. | Optimized sample injection structures in microfluidic separations |
US7888017B2 (en) * | 2006-02-02 | 2011-02-15 | The Board Of Trustees Of The Leland Stanford Junior University | Non-invasive fetal genetic screening by digital analysis |
WO2008030631A2 (en) | 2006-02-03 | 2008-03-13 | Microchip Biotechnologies, Inc. | Microfluidic devices |
US20100304446A1 (en) * | 2006-02-07 | 2010-12-02 | Stokes Bio Limited | Devices, systems, and methods for amplifying nucleic acids |
WO2007091230A1 (en) | 2006-02-07 | 2007-08-16 | Stokes Bio Limited | A microfluidic analysis system |
EP1991657A4 (en) * | 2006-03-02 | 2011-03-23 | Univ California | Integrated microfluidics for parallel screening of chemical reactions |
WO2007106579A2 (en) * | 2006-03-15 | 2007-09-20 | Micronics, Inc. | Integrated nucleic acid assays |
US7766033B2 (en) | 2006-03-22 | 2010-08-03 | The Regents Of The University Of California | Multiplexed latching valves for microfluidic devices and processors |
US10900066B2 (en) | 2006-03-24 | 2021-01-26 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
US7998708B2 (en) | 2006-03-24 | 2011-08-16 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
JP5415253B2 (en) | 2006-03-24 | 2014-02-12 | ハンディラブ・インコーポレーテッド | Integrated system for processing microfluidic samples and methods of use thereof |
US11806718B2 (en) | 2006-03-24 | 2023-11-07 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
US9476856B2 (en) | 2006-04-13 | 2016-10-25 | Advanced Liquid Logic, Inc. | Droplet-based affinity assays |
US8637317B2 (en) * | 2006-04-18 | 2014-01-28 | Advanced Liquid Logic, Inc. | Method of washing beads |
US8492168B2 (en) | 2006-04-18 | 2013-07-23 | Advanced Liquid Logic Inc. | Droplet-based affinity assays |
US20140193807A1 (en) | 2006-04-18 | 2014-07-10 | Advanced Liquid Logic, Inc. | Bead manipulation techniques |
US7727723B2 (en) * | 2006-04-18 | 2010-06-01 | Advanced Liquid Logic, Inc. | Droplet-based pyrosequencing |
US8716015B2 (en) | 2006-04-18 | 2014-05-06 | Advanced Liquid Logic, Inc. | Manipulation of cells on a droplet actuator |
US10078078B2 (en) | 2006-04-18 | 2018-09-18 | Advanced Liquid Logic, Inc. | Bead incubation and washing on a droplet actuator |
US7815871B2 (en) | 2006-04-18 | 2010-10-19 | Advanced Liquid Logic, Inc. | Droplet microactuator system |
US7816121B2 (en) | 2006-04-18 | 2010-10-19 | Advanced Liquid Logic, Inc. | Droplet actuation system and method |
US8809068B2 (en) | 2006-04-18 | 2014-08-19 | Advanced Liquid Logic, Inc. | Manipulation of beads in droplets and methods for manipulating droplets |
US7901947B2 (en) | 2006-04-18 | 2011-03-08 | Advanced Liquid Logic, Inc. | Droplet-based particle sorting |
US7439014B2 (en) | 2006-04-18 | 2008-10-21 | Advanced Liquid Logic, Inc. | Droplet-based surface modification and washing |
US8637324B2 (en) | 2006-04-18 | 2014-01-28 | Advanced Liquid Logic, Inc. | Bead incubation and washing on a droplet actuator |
WO2007123908A2 (en) | 2006-04-18 | 2007-11-01 | Advanced Liquid Logic, Inc. | Droplet-based multiwell operations |
US8828661B2 (en) | 2006-04-24 | 2014-09-09 | Fluidigm Corporation | Methods for detection and quantification of nucleic acid or protein targets in a sample |
US8900828B2 (en) | 2006-05-01 | 2014-12-02 | Cepheid | Methods and apparatus for sequential amplification reactions |
CN101500709A (en) * | 2006-05-01 | 2009-08-05 | 皇家飞利浦电子股份有限公司 | Fluid sample transport device with reduced dead volume for processing, controlling and/or detecting a fluid sample |
US7939021B2 (en) | 2007-05-09 | 2011-05-10 | Advanced Liquid Logic, Inc. | Droplet actuator analyzer with cartridge |
US8041463B2 (en) * | 2006-05-09 | 2011-10-18 | Advanced Liquid Logic, Inc. | Modular droplet actuator drive |
US7822510B2 (en) | 2006-05-09 | 2010-10-26 | Advanced Liquid Logic, Inc. | Systems, methods, and products for graphically illustrating and controlling a droplet actuator |
US9562837B2 (en) | 2006-05-11 | 2017-02-07 | Raindance Technologies, Inc. | Systems for handling microfludic droplets |
US20080014589A1 (en) | 2006-05-11 | 2008-01-17 | Link Darren R | Microfluidic devices and methods of use thereof |
US7641860B2 (en) * | 2006-06-01 | 2010-01-05 | Nanotek, Llc | Modular and reconfigurable multi-stage microreactor cartridge apparatus |
US7998418B1 (en) | 2006-06-01 | 2011-08-16 | Nanotek, Llc | Evaporator and concentrator in reactor and loading system |
US20080070792A1 (en) | 2006-06-14 | 2008-03-20 | Roland Stoughton | Use of highly parallel snp genotyping for fetal diagnosis |
EP2589668A1 (en) | 2006-06-14 | 2013-05-08 | Verinata Health, Inc | Rare cell analysis using sample splitting and DNA tags |
US8137912B2 (en) | 2006-06-14 | 2012-03-20 | The General Hospital Corporation | Methods for the diagnosis of fetal abnormalities |
US20080050739A1 (en) | 2006-06-14 | 2008-02-28 | Roland Stoughton | Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats |
US8119352B2 (en) * | 2006-06-20 | 2012-02-21 | Cepheld | Multi-stage amplification reactions by control of sequence replication times |
EP1870027A1 (en) * | 2006-06-21 | 2007-12-26 | Trace Analytics GmbH | Devices and method for detecting an analyte |
DE102006030068A1 (en) * | 2006-06-28 | 2008-01-03 | M2P-Labs Gmbh | Apparatus and method for the supply and removal of fluids in shaken microreactors arrays |
WO2008005246A2 (en) * | 2006-06-30 | 2008-01-10 | Canon U.S. Life Sciences, Inc. | Systems and methods for monitoring the amplification and dissociation behavior of dna molecules |
US7629124B2 (en) * | 2006-06-30 | 2009-12-08 | Canon U.S. Life Sciences, Inc. | Real-time PCR in micro-channels |
WO2008005241A2 (en) * | 2006-06-30 | 2008-01-10 | Canon U.S. Life Sciences, Inc. | Systems and methods for monitoring the amplification and dissociation behavior of dna molecules |
JP4899681B2 (en) * | 2006-07-18 | 2012-03-21 | 富士ゼロックス株式会社 | Microchannel device |
EP2077912B1 (en) | 2006-08-07 | 2019-03-27 | The President and Fellows of Harvard College | Fluorocarbon emulsion stabilizing surfactants |
US8656949B2 (en) * | 2006-08-15 | 2014-02-25 | University Of Maryland College Park | Microfluidic devices and methods of fabrication |
US20090047673A1 (en) * | 2006-08-22 | 2009-02-19 | Cary Robert B | Miniaturized lateral flow device for rapid and sensitive detection of proteins or nucleic acids |
US8980561B1 (en) | 2006-08-22 | 2015-03-17 | Los Alamos National Security, Llc. | Nucleic acid detection system and method for detecting influenza |
US7854902B2 (en) * | 2006-08-23 | 2010-12-21 | Nanotek, Llc | Modular and reconfigurable multi-stage high temperature microreactor cartridge apparatus and system for using same |
US8055034B2 (en) | 2006-09-13 | 2011-11-08 | Fluidigm Corporation | Methods and systems for image processing of microfluidic devices |
US10753927B2 (en) | 2006-09-22 | 2020-08-25 | ALERE TECHNOLOGIES GmbH | Methods for detecting an analyte |
WO2008135564A2 (en) * | 2007-05-03 | 2008-11-13 | Clondiag Gmbh | Assays |
US8163480B2 (en) * | 2006-10-05 | 2012-04-24 | Quest Diagnostics Investments Incorporated | Nucleic acid size detection method |
US8841116B2 (en) | 2006-10-25 | 2014-09-23 | The Regents Of The University Of California | Inline-injection microdevice and microfabricated integrated DNA analysis system using same |
WO2008055915A2 (en) * | 2006-11-06 | 2008-05-15 | Clondiag Gmbh | Device and process for assays using binding members |
WO2008061165A2 (en) | 2006-11-14 | 2008-05-22 | Handylab, Inc. | Microfluidic cartridge and method of making same |
WO2008060604A2 (en) | 2006-11-14 | 2008-05-22 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
US9102911B2 (en) | 2009-05-15 | 2015-08-11 | Biofire Diagnostics, Llc | High density self-contained biological analysis |
US9114398B2 (en) * | 2006-11-29 | 2015-08-25 | Canon U.S. Life Sciences, Inc. | Device and method for digital multiplex PCR assays |
US7593560B2 (en) * | 2006-11-30 | 2009-09-22 | Canon U.S. Life Sciences, Inc. | Systems and methods for monitoring the amplification and dissociation behavior of DNA molecules |
WO2008067552A2 (en) * | 2006-11-30 | 2008-06-05 | Fluidigm Corporation | Method and apparatus for biological sample analysis |
EP1931158B1 (en) * | 2006-12-08 | 2013-04-10 | Samsung Electronics Co., Ltd. | Apparatus and method for selecting frame structure in multihop relay broadband wireless access communication system |
US8262900B2 (en) | 2006-12-14 | 2012-09-11 | Life Technologies Corporation | Methods and apparatus for measuring analytes using large scale FET arrays |
EP4134667A1 (en) | 2006-12-14 | 2023-02-15 | Life Technologies Corporation | Apparatus for measuring analytes using fet arrays |
US11339430B2 (en) | 2007-07-10 | 2022-05-24 | Life Technologies Corporation | Methods and apparatus for measuring analytes using large scale FET arrays |
WO2008089493A2 (en) * | 2007-01-19 | 2008-07-24 | Fluidigm Corporation | High precision microfluidic devices and methods |
US7829032B2 (en) * | 2007-01-23 | 2010-11-09 | Siemens Medical Solutions Usa, Inc. | Fully-automated microfluidic system for the synthesis of radiolabeled biomarkers for positron emission tomography |
US8617903B2 (en) | 2007-01-29 | 2013-12-31 | The Invention Science Fund I, Llc | Methods for allergen detection |
US10001496B2 (en) | 2007-01-29 | 2018-06-19 | Gearbox, Llc | Systems for allergen detection |
WO2008115626A2 (en) * | 2007-02-05 | 2008-09-25 | Microchip Biotechnologies, Inc. | Microfluidic and nanofluidic devices, systems, and applications |
US8772046B2 (en) | 2007-02-06 | 2014-07-08 | Brandeis University | Manipulation of fluids and reactions in microfluidic systems |
WO2008118808A1 (en) | 2007-03-23 | 2008-10-02 | Advion Bioscience, Inc. | Liquid chromatography-mass spectrometry |
JP5151204B2 (en) * | 2007-03-27 | 2013-02-27 | 富士ゼロックス株式会社 | Microchannel device and method of manufacturing microchannel device |
US20090227005A1 (en) * | 2007-03-27 | 2009-09-10 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Methods for pathogen detection |
US8071035B2 (en) * | 2007-04-12 | 2011-12-06 | Siemens Medical Solutions Usa, Inc. | Microfluidic radiosynthesis system for positron emission tomography biomarkers |
US8592221B2 (en) | 2007-04-19 | 2013-11-26 | Brandeis University | Manipulation of fluids, fluid components and reactions in microfluidic systems |
JP5205802B2 (en) * | 2007-05-11 | 2013-06-05 | ソニー株式会社 | Real-time PCR device |
CA2691451C (en) | 2007-06-21 | 2015-03-24 | Sara H. Fan | Instrument and receptacles for performing processes |
US9618139B2 (en) | 2007-07-13 | 2017-04-11 | Handylab, Inc. | Integrated heater and magnetic separator |
US8287820B2 (en) | 2007-07-13 | 2012-10-16 | Handylab, Inc. | Automated pipetting apparatus having a combined liquid pump and pipette head system |
US9186677B2 (en) | 2007-07-13 | 2015-11-17 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
US8182763B2 (en) | 2007-07-13 | 2012-05-22 | Handylab, Inc. | Rack for sample tubes and reagent holders |
US8105783B2 (en) | 2007-07-13 | 2012-01-31 | Handylab, Inc. | Microfluidic cartridge |
CA2693654C (en) | 2007-07-13 | 2018-02-13 | Handylab, Inc. | Polynucleotide capture materials, and methods of using same |
PT2557517T (en) | 2007-07-23 | 2023-01-04 | Univ Hong Kong Chinese | Determining a nucleic acid sequence imbalance |
US20100112590A1 (en) | 2007-07-23 | 2010-05-06 | The Chinese University Of Hong Kong | Diagnosing Fetal Chromosomal Aneuploidy Using Genomic Sequencing With Enrichment |
US8454906B2 (en) * | 2007-07-24 | 2013-06-04 | The Regents Of The University Of California | Microfabricated droplet generator for single molecule/cell genetic analysis in engineered monodispersed emulsions |
EP2171420A1 (en) * | 2007-07-31 | 2010-04-07 | Micronics, Inc. | Sanitary swab collection system, microfluidic assay device, and methods for diagnostic assays |
WO2009020982A1 (en) * | 2007-08-06 | 2009-02-12 | The Regents Of The University Of California | Nano-microfluidic apparatus for continuous real-time analysis of targets in thin liquid films |
WO2009021233A2 (en) | 2007-08-09 | 2009-02-12 | Advanced Liquid Logic, Inc. | Pcb droplet actuator fabrication |
US8306773B2 (en) | 2007-08-29 | 2012-11-06 | Canon U.S. Life Sciences, Inc. | Microfluidic devices with integrated resistive heater electrodes including systems and methods for controlling and measuring the temperatures of such heater electrodes |
US9221056B2 (en) * | 2007-08-29 | 2015-12-29 | Canon U.S. Life Sciences, Inc. | Microfluidic devices with integrated resistive heater electrodes including systems and methods for controlling and measuring the temperatures of such heater electrodes |
US8380457B2 (en) * | 2007-08-29 | 2013-02-19 | Canon U.S. Life Sciences, Inc. | Microfluidic devices with integrated resistive heater electrodes including systems and methods for controlling and measuring the temperatures of such heater electrodes |
WO2009033178A1 (en) | 2007-09-07 | 2009-03-12 | Fluidigm Corporation | Copy number variation determination, methods and systems |
AU2008298612A1 (en) | 2007-09-14 | 2009-03-19 | University Of South Florida | Gene signature for the prediction of radiation therapy response |
CA2700946A1 (en) * | 2007-09-28 | 2009-04-02 | University Of Toronto | A system, apparatus and method for applying mechanical force to a material |
JP5119848B2 (en) * | 2007-10-12 | 2013-01-16 | 富士ゼロックス株式会社 | Microreactor device |
WO2009049268A1 (en) | 2007-10-12 | 2009-04-16 | Rheonix, Inc. | Integrated microfluidic device and methods |
WO2009055050A1 (en) | 2007-10-25 | 2009-04-30 | Canon U.S. Life Sciences, Inc | High-resolution melting analysis |
US9114397B2 (en) * | 2007-10-25 | 2015-08-25 | Canon U.S. Life Sciences, Inc. | Method of reducing cross-contamination in continuous amplification reactions in a channel |
US20090130746A1 (en) * | 2007-10-25 | 2009-05-21 | Canon U.S. Life Sciences, Inc. | Microchannel surface coating |
WO2009059022A1 (en) | 2007-10-30 | 2009-05-07 | Complete Genomics, Inc. | Apparatus for high throughput sequencing of nucleic acids |
EP2212437A4 (en) * | 2007-11-07 | 2011-09-28 | Univ British Columbia | Microfluidic device and method of using same |
US9551026B2 (en) | 2007-12-03 | 2017-01-24 | Complete Genomincs, Inc. | Method for nucleic acid detection using voltage enhancement |
JP5224801B2 (en) * | 2007-12-21 | 2013-07-03 | キヤノン株式会社 | Nucleic acid amplification equipment |
US8189186B2 (en) * | 2007-12-27 | 2012-05-29 | Lawrence Livermore National Security, Llc. | Signal enhancement using a switchable magnetic trap |
US9170060B2 (en) * | 2008-01-22 | 2015-10-27 | Lawrence Livermore National Security, Llc | Rapid microfluidic thermal cycler for nucleic acid amplification |
WO2009108260A2 (en) * | 2008-01-22 | 2009-09-03 | Microchip Biotechnologies, Inc. | Universal sample preparation system and use in an integrated analysis system |
US9157116B2 (en) * | 2008-02-08 | 2015-10-13 | Fluidigm Corporation | Combinatorial amplification and detection of nucleic acids |
EP3636341B1 (en) * | 2008-03-14 | 2021-12-08 | Abbott Rapid Diagnostics Jena GmbH | Assays and devices |
US8367976B2 (en) | 2008-03-21 | 2013-02-05 | Lawrence Livermore National Security, Llc | Laser heating of aqueous samples on a micro-optical-electro-mechanical system |
EP2280905B1 (en) | 2008-04-11 | 2016-07-06 | Fluidigm Corporation | Multilevel microfluidic systems and methods |
EP2279403B1 (en) | 2008-05-05 | 2016-03-16 | Los Alamos National Security, LLC | Highly simplified lateral flow-based nucleic acid sample preparation and passive fluid flow control |
US9879360B2 (en) * | 2008-06-20 | 2018-01-30 | International Business Machines Corporation | Microfluidic selection of library elements |
EP2138587A1 (en) * | 2008-06-23 | 2009-12-30 | Koninklijke Philips Electronics N.V. | Amplification of nucleic acids using temperature zones |
US9724695B2 (en) | 2008-06-23 | 2017-08-08 | Canon U.S. Life Sciences, Inc. | Systems and methods for amplifying nucleic acids |
US8122901B2 (en) | 2008-06-30 | 2012-02-28 | Canon U.S. Life Sciences, Inc. | System and method for microfluidic flow control |
US20090325159A1 (en) * | 2008-06-30 | 2009-12-31 | Canon U.S. Life Sciences, Inc. | System and method to prevent cross-contamination in assays performed in a microfluidic channel |
USD787087S1 (en) | 2008-07-14 | 2017-05-16 | Handylab, Inc. | Housing |
WO2010009365A1 (en) | 2008-07-18 | 2010-01-21 | Raindance Technologies, Inc. | Droplet libraries |
EP2315848B1 (en) * | 2008-07-18 | 2014-12-10 | Canon U.S. Life Sciences, Inc. | Methods and systems for microfluidic dna sample preparation |
CN104043490A (en) | 2008-07-25 | 2014-09-17 | 弗卢丁公司 | Method and system for manufacturing integrated fluidic chips |
WO2010017210A1 (en) | 2008-08-07 | 2010-02-11 | Fluidigm Corporation | Microfluidic mixing and reaction systems for high efficiency screening |
US10123380B2 (en) | 2008-08-08 | 2018-11-06 | Lawrence Livermore National Security, Llc | Instantaneous in-line heating of samples on a monolithic microwave integrated circuit microfluidic device |
US9540686B2 (en) * | 2008-09-18 | 2017-01-10 | Canon U.S. Life Sciences, Inc. | Systems and methods for the amplification of DNA |
SI2334812T1 (en) | 2008-09-20 | 2017-05-31 | The Board of Trustees of the Leland Stanford Junior University Office of the General Counsel Building 170 | Noninvasive diagnosis of fetal aneuploidy by sequencing |
US8951939B2 (en) | 2011-07-12 | 2015-02-10 | Bio-Rad Laboratories, Inc. | Digital assays with multiplexed detection of two or more targets in the same optical channel |
US8709762B2 (en) | 2010-03-02 | 2014-04-29 | Bio-Rad Laboratories, Inc. | System for hot-start amplification via a multiple emulsion |
US9132394B2 (en) | 2008-09-23 | 2015-09-15 | Bio-Rad Laboratories, Inc. | System for detection of spaced droplets |
WO2011120006A1 (en) | 2010-03-25 | 2011-09-29 | Auantalife, Inc. A Delaware Corporation | Detection system for droplet-based assays |
US8633015B2 (en) * | 2008-09-23 | 2014-01-21 | Bio-Rad Laboratories, Inc. | Flow-based thermocycling system with thermoelectric cooler |
US9399215B2 (en) | 2012-04-13 | 2016-07-26 | Bio-Rad Laboratories, Inc. | Sample holder with a well having a wicking promoter |
US9417190B2 (en) | 2008-09-23 | 2016-08-16 | Bio-Rad Laboratories, Inc. | Calibrations and controls for droplet-based assays |
US8663920B2 (en) | 2011-07-29 | 2014-03-04 | Bio-Rad Laboratories, Inc. | Library characterization by digital assay |
US8082810B2 (en) * | 2008-09-29 | 2011-12-27 | Ysi Incorporated | Microfluidic elastic micro-aliquotter |
US20100093098A1 (en) * | 2008-10-14 | 2010-04-15 | Siemens Medical Solutions | Nonflow-through appratus and mehod using enhanced flow mechanisms |
US11951474B2 (en) | 2008-10-22 | 2024-04-09 | Life Technologies Corporation | Fluidics systems for sequential delivery of reagents |
US8546128B2 (en) | 2008-10-22 | 2013-10-01 | Life Technologies Corporation | Fluidics system for sequential delivery of reagents |
US20100301398A1 (en) | 2009-05-29 | 2010-12-02 | Ion Torrent Systems Incorporated | Methods and apparatus for measuring analytes |
US20100137143A1 (en) | 2008-10-22 | 2010-06-03 | Ion Torrent Systems Incorporated | Methods and apparatus for measuring analytes |
CH699853A1 (en) * | 2008-11-13 | 2010-05-14 | Tecan Trading Ag | Meter and method for determining provided by a laboratory fluid system parameters. |
JP2010115624A (en) | 2008-11-14 | 2010-05-27 | Fuji Xerox Co Ltd | Microchannel device, separation device, and separation method |
US20100129872A1 (en) * | 2008-11-24 | 2010-05-27 | Ghc Technologies, Inc. | System and method for movement and positioning of reaction mixture during nucleic acid amplification |
US10434514B2 (en) * | 2008-12-05 | 2019-10-08 | Biocartis S.A. | Thermal cycling system comprising transport heater |
KR20110111449A (en) * | 2008-12-31 | 2011-10-11 | 인터젠엑스 인크. | Instrument with microfluidic chip |
US8058630B2 (en) * | 2009-01-16 | 2011-11-15 | Fluidigm Corporation | Microfluidic devices and methods |
US9404152B2 (en) | 2009-01-26 | 2016-08-02 | Canon U.S. Life Sciences, Inc. | Microfluidic flow monitoring |
US10066977B2 (en) | 2009-01-26 | 2018-09-04 | Canon U.S. Life Sciences, Inc. | Microfluidic flow monitoring |
US9542526B2 (en) * | 2009-03-10 | 2017-01-10 | Canon U.S. Life Sciences, Inc. | Method and system for temperature correction in thermal melt analysis |
JP5003702B2 (en) | 2009-03-16 | 2012-08-15 | 富士ゼロックス株式会社 | Microfluidic device and microfluidic control method |
US8528589B2 (en) | 2009-03-23 | 2013-09-10 | Raindance Technologies, Inc. | Manipulation of microfluidic droplets |
WO2010111690A2 (en) | 2009-03-27 | 2010-09-30 | Life Technologies Corporation | Polymerase compositions and methods |
WO2010118430A1 (en) | 2009-04-10 | 2010-10-14 | Canon U.S. Life Sciences, Inc. | A method of delivering pcr solution to microfluidic pcr chamber |
JP5709840B2 (en) * | 2009-04-13 | 2015-04-30 | キヤノン ユー.エス. ライフ サイエンシズ, インコーポレイテッドCanon U.S. Life Sciences, Inc. | Rapid method of pattern recognition, machine learning, and automatic genotyping with dynamic signal correlation analysis |
US8337082B2 (en) | 2009-05-08 | 2012-12-25 | Canon U.S. Life Sciences, Inc. | Systems and methods for auto-calibration of resistive temperature sensors |
US8329117B2 (en) * | 2009-05-14 | 2012-12-11 | Canon U.S. Life Sciences, Inc. | Microfluidic chip features for optical and thermal isolation |
CN102459565A (en) * | 2009-06-02 | 2012-05-16 | 尹特根埃克斯有限公司 | Fluidic devices with diaphragm valves |
AU2010257118B2 (en) * | 2009-06-04 | 2014-08-28 | Lockheed Martin Corporation | Multiple-sample microfluidic chip for DNA analysis |
JP2012529268A (en) | 2009-06-05 | 2012-11-22 | インテジェンクス,インコーポレイテッド | Use of universal sample preparation system and integrated analysis system |
EP2451578A4 (en) * | 2009-06-29 | 2013-04-10 | Canon Us Life Sciences Inc | Microfluidic systems and methods for thermal control |
US8551787B2 (en) * | 2009-07-23 | 2013-10-08 | Fluidigm Corporation | Microfluidic devices and methods for binary mixing |
SG169918A1 (en) | 2009-10-02 | 2011-04-29 | Fluidigm Corp | Microfluidic devices with removable cover and methods of fabrication and application |
EP2486409A1 (en) | 2009-10-09 | 2012-08-15 | Universite De Strasbourg | Labelled silica-based nanomaterial with enhanced properties and uses thereof |
KR101472581B1 (en) | 2009-10-21 | 2014-12-16 | 비오까르띠 엔브이 | Microfluidic cartridge with parallel pneumatic interface plate |
US20110143378A1 (en) * | 2009-11-12 | 2011-06-16 | CyVek LLC. | Microfluidic method and apparatus for high performance biological assays |
US9500645B2 (en) | 2009-11-23 | 2016-11-22 | Cyvek, Inc. | Micro-tube particles for microfluidic assays and methods of manufacture |
US10065403B2 (en) | 2009-11-23 | 2018-09-04 | Cyvek, Inc. | Microfluidic assay assemblies and methods of manufacture |
US9651568B2 (en) | 2009-11-23 | 2017-05-16 | Cyvek, Inc. | Methods and systems for epi-fluorescent monitoring and scanning for microfluidic assays |
US9700889B2 (en) | 2009-11-23 | 2017-07-11 | Cyvek, Inc. | Methods and systems for manufacture of microarray assay systems, conducting microfluidic assays, and monitoring and scanning to obtain microfluidic assay results |
US9855735B2 (en) | 2009-11-23 | 2018-01-02 | Cyvek, Inc. | Portable microfluidic assay devices and methods of manufacture and use |
JP5701894B2 (en) | 2009-11-23 | 2015-04-15 | サイヴェク・インコーポレイテッド | Method and apparatus for performing an assay |
US9759718B2 (en) | 2009-11-23 | 2017-09-12 | Cyvek, Inc. | PDMS membrane-confined nucleic acid and antibody/antigen-functionalized microlength tube capture elements, and systems employing them, and methods of their use |
EP2506882A4 (en) | 2009-11-30 | 2017-05-17 | Fluidigm Corporation | Microfluidic device regeneration |
US8584703B2 (en) | 2009-12-01 | 2013-11-19 | Integenx Inc. | Device with diaphragm valve |
US10837883B2 (en) | 2009-12-23 | 2020-11-17 | Bio-Rad Laboratories, Inc. | Microfluidic systems and methods for reducing the exchange of molecules between droplets |
US8398418B2 (en) | 2010-01-07 | 2013-03-19 | Life Technologies Corporation | Electronic connector having a clamping member urging a flow cell toward an electrical circuitry with an electrically conductive membrane disposed in between |
WO2011091046A1 (en) | 2010-01-19 | 2011-07-28 | Verinata Health, Inc. | Identification of polymorphic sequences in mixtures of genomic dna by whole genome sequencing |
US9353342B2 (en) | 2010-01-21 | 2016-05-31 | Emd Millipore Corporation | Cell culture and gradient migration assay methods and devices |
KR101851117B1 (en) | 2010-01-29 | 2018-04-23 | 마이크로닉스 인코포레이티드. | Sample-to-answer microfluidic cartridge |
US9366632B2 (en) | 2010-02-12 | 2016-06-14 | Raindance Technologies, Inc. | Digital analyte analysis |
US10351905B2 (en) | 2010-02-12 | 2019-07-16 | Bio-Rad Laboratories, Inc. | Digital analyte analysis |
US9399797B2 (en) | 2010-02-12 | 2016-07-26 | Raindance Technologies, Inc. | Digital analyte analysis |
WO2011100604A2 (en) | 2010-02-12 | 2011-08-18 | Raindance Technologies, Inc. | Digital analyte analysis |
CA2767114A1 (en) | 2010-03-25 | 2011-09-29 | Bio-Rad Laboratories, Inc. | Droplet transport system for detection |
US8512538B2 (en) | 2010-05-28 | 2013-08-20 | Integenx Inc. | Capillary electrophoresis device |
EP2588859B1 (en) | 2010-06-29 | 2019-05-22 | Canon U.S. Life Sciences, Inc. | System and method for genotype analysis |
EP2588851B1 (en) | 2010-06-30 | 2016-12-21 | Life Technologies Corporation | Ion-sensing charge-accumulation circuit and method |
CN106198656B (en) | 2010-08-18 | 2018-12-11 | 生命科技股份有限公司 | The immersion coating of micropore for electrochemical detection device |
WO2012024658A2 (en) | 2010-08-20 | 2012-02-23 | IntegenX, Inc. | Integrated analysis system |
WO2012024657A1 (en) | 2010-08-20 | 2012-02-23 | IntegenX, Inc. | Microfluidic devices with mechanically-sealed diaphragm valves |
EP2611899A4 (en) | 2010-08-31 | 2017-06-21 | Canon U.S. Life Sciences, Inc. | Composition and method for in-system priming microfluidic devices |
EP2612096B1 (en) | 2010-08-31 | 2019-06-12 | Canon U.S. Life Sciences, Inc. | Air cooling systems and methods for microfluidic devices |
WO2012030995A2 (en) | 2010-08-31 | 2012-03-08 | Canon U.S. Life Sciences, Inc. | Optical system for high resolution thermal melt detection |
EP3447155A1 (en) | 2010-09-30 | 2019-02-27 | Raindance Technologies, Inc. | Sandwich assays in droplets |
EP2441520A1 (en) | 2010-10-12 | 2012-04-18 | Eppendorf AG | Real-time amplification and micro-array based detection of nucleic acid targets in a flow chip assay |
MX2013004184A (en) | 2010-10-15 | 2013-07-29 | Lockheed Corp | Micro fluidic optic design. |
WO2012054933A2 (en) | 2010-10-22 | 2012-04-26 | Fluidigm Corporation | Universal probe assay methods |
WO2012075360A1 (en) | 2010-12-03 | 2012-06-07 | Idaho Technology, Inc. | Thermal cycler apparatus and related methods |
US9594870B2 (en) | 2010-12-29 | 2017-03-14 | Life Technologies Corporation | Time-warped background signal for sequencing-by-synthesis operations |
EP2658999B1 (en) | 2010-12-30 | 2019-03-13 | Life Technologies Corporation | Models for analyzing data from sequencing-by-synthesis operations |
US10241075B2 (en) | 2010-12-30 | 2019-03-26 | Life Technologies Corporation | Methods, systems, and computer readable media for nucleic acid sequencing |
US20130060482A1 (en) | 2010-12-30 | 2013-03-07 | Life Technologies Corporation | Methods, systems, and computer readable media for making base calls in nucleic acid sequencing |
WO2012109600A2 (en) | 2011-02-11 | 2012-08-16 | Raindance Technologies, Inc. | Methods for forming mixed droplets |
US9266104B2 (en) * | 2011-02-11 | 2016-02-23 | Raindance Technologies, Inc. | Thermocycling device for nucleic acid amplification and methods of use |
WO2012112804A1 (en) | 2011-02-18 | 2012-08-23 | Raindance Technoligies, Inc. | Compositions and methods for molecular labeling |
CN103534360A (en) | 2011-03-18 | 2014-01-22 | 伯乐生命医学产品有限公司 | Multiplexed digital assays with combinatorial use of signals |
CN106552682B (en) | 2011-03-22 | 2020-06-19 | 西维克公司 | Microfluidic device and methods of manufacture and use |
US9168531B2 (en) | 2011-03-24 | 2015-10-27 | Fluidigm Corporation | Method for thermal cycling of microfluidic samples |
US10526572B2 (en) | 2011-04-01 | 2020-01-07 | EMD Millipore Corporaticn | Cell culture and invasion assay method and system |
CA3082652A1 (en) | 2011-04-15 | 2012-10-18 | Becton, Dickinson And Company | Scanning real-time microfluidic thermocycler and methods for synchronized thermocycling and scanning optical detection |
DK2699700T3 (en) | 2011-04-20 | 2016-08-01 | Mesa Biotech Inc | Integrated device for nukleinsyreregistrering and identification |
DE102011017596A1 (en) * | 2011-04-27 | 2012-10-31 | Robert Bosch Gmbh | Microfluidic system and method for polymerase chain reaction |
US9644231B2 (en) | 2011-05-09 | 2017-05-09 | Fluidigm Corporation | Nucleic acid detection using probes |
WO2012154876A1 (en) | 2011-05-09 | 2012-11-15 | Fluidigm Corporation | Probe based nucleic acid detection |
US8841071B2 (en) | 2011-06-02 | 2014-09-23 | Raindance Technologies, Inc. | Sample multiplexing |
WO2013009927A2 (en) | 2011-07-11 | 2013-01-17 | Advanced Liquid Logic, Inc. | Droplet actuators and techniques for droplet-based assays |
EP3081937B1 (en) | 2011-07-18 | 2019-11-13 | President and Fellows of Harvard College | Engineered microbe-targeting molecules and uses thereof |
US8658430B2 (en) | 2011-07-20 | 2014-02-25 | Raindance Technologies, Inc. | Manipulating droplet size |
US9207690B2 (en) * | 2011-09-23 | 2015-12-08 | Analogic Corporation | Thermal cycling |
DK2761305T3 (en) | 2011-09-30 | 2017-11-20 | Becton Dickinson Co | United Reagent Strip |
USD692162S1 (en) | 2011-09-30 | 2013-10-22 | Becton, Dickinson And Company | Single piece reagent holder |
US20150136604A1 (en) | 2011-10-21 | 2015-05-21 | Integenx Inc. | Sample preparation, processing and analysis systems |
US10865440B2 (en) | 2011-10-21 | 2020-12-15 | IntegenX, Inc. | Sample preparation, processing and analysis systems |
US9128046B2 (en) * | 2011-10-31 | 2015-09-08 | Cellomics, Inc. | Slide holder assembly for comet assay |
US9689835B2 (en) | 2011-10-31 | 2017-06-27 | Taiwan Semiconductor Manufacturing Company, Ltd. | Amplified dual-gate bio field effect transistor |
US9459234B2 (en) | 2011-10-31 | 2016-10-04 | Taiwan Semiconductor Manufacturing Company, Ltd., (“TSMC”) | CMOS compatible BioFET |
US10837879B2 (en) | 2011-11-02 | 2020-11-17 | Complete Genomics, Inc. | Treatment for stabilizing nucleic acid arrays |
EP2773892B1 (en) | 2011-11-04 | 2020-10-07 | Handylab, Inc. | Polynucleotide sample preparation device |
ES2870857T3 (en) | 2011-12-03 | 2021-10-27 | Emd Millipore Corp | Microfluidic system for cell culture |
EP2872523B1 (en) | 2011-12-30 | 2018-01-17 | Abbott Molecular Inc. | Microorganism nucleic acid purification from host samples |
US9194840B2 (en) | 2012-01-19 | 2015-11-24 | Life Technologies Corporation | Sensor arrays and methods for making same |
RU2658773C2 (en) | 2012-02-03 | 2018-06-22 | Бектон, Дикинсон Энд Компани | System and method of implementation of automated assays on plurality of biological samples |
US9322054B2 (en) | 2012-02-22 | 2016-04-26 | Lockheed Martin Corporation | Microfluidic cartridge |
US9304065B2 (en) | 2012-02-29 | 2016-04-05 | Fluidigm Corporation | Methods, systems and devices for multiple single-cell capturing and processing using microfluidics |
KR102114734B1 (en) | 2012-03-08 | 2020-05-25 | 싸이벡, 아이엔씨 | Micro-tube particles for microfluidic assays and methods of manufacture |
WO2013132645A1 (en) | 2012-03-09 | 2013-09-12 | 独立行政法人産業技術総合研究所 | Nucleic acid amplification method |
US9803239B2 (en) | 2012-03-29 | 2017-10-31 | Complete Genomics, Inc. | Flow cells for high density array chips |
CA2867665C (en) * | 2012-04-03 | 2022-01-04 | Illumina, Inc. | Integrated optoelectronic read head and fluidic cartridge useful for nucleic acid sequencing |
US9646132B2 (en) | 2012-05-11 | 2017-05-09 | Life Technologies Corporation | Models for analyzing data from sequencing-by-synthesis operations |
EP2875078B1 (en) | 2012-07-18 | 2017-12-20 | President and Fellows of Harvard College | Modification of surfaces for simulataneous repellency and targeted binding of desired moieties |
US20140322706A1 (en) | 2012-10-24 | 2014-10-30 | Jon Faiz Kayyem | Integrated multipelx target analysis |
CA2889415C (en) | 2012-10-24 | 2020-06-02 | Genmark Diagnostics, Inc. | Integrated multiplex target analysis |
US8728844B1 (en) | 2012-12-05 | 2014-05-20 | Taiwan Semiconductor Manufacturing Company, Ltd. | Backside CMOS compatible bioFET with no plasma induced damage |
WO2014100725A1 (en) | 2012-12-21 | 2014-06-26 | Micronics, Inc. | Portable fluorescence detection system and microassay cartridge |
EP2935908B1 (en) | 2012-12-21 | 2019-08-14 | PerkinElmer Health Sciences, Inc. | Fluidic circuits and related manufacturing methods |
WO2014100743A2 (en) | 2012-12-21 | 2014-06-26 | Micronics, Inc. | Low elasticity films for microfluidic use |
CN103060193A (en) * | 2012-12-31 | 2013-04-24 | 苏州汶颢芯片科技有限公司 | Novel temperature response micro-fluidic cell culturing chip and preparation method thereof |
WO2014113663A1 (en) * | 2013-01-18 | 2014-07-24 | Hill David A | In-line polymerase chain reaction |
US9625493B2 (en) * | 2013-02-22 | 2017-04-18 | Taiwan Semiconductor Manufacturing Company, Ltd. | Process control monitoring for biochips |
US20140255270A1 (en) * | 2013-02-28 | 2014-09-11 | California Institute Of Technology | Removing sacrificial layer to form liquid containment structure and methods of use thereof |
US8963216B2 (en) | 2013-03-13 | 2015-02-24 | Life Technologies Corporation | Chemical sensor with sidewall spacer sensor surface |
US20140264468A1 (en) | 2013-03-14 | 2014-09-18 | Taiwan Semiconductor Manufacturing Company, Ltd. | Biofet with increased sensing area |
US9389199B2 (en) | 2013-03-14 | 2016-07-12 | Taiwan Semiconductor Manufacturing Company, Ltd. | Backside sensing bioFET with enhanced performance |
EP2969217A2 (en) | 2013-03-15 | 2016-01-20 | Genmark Diagnostics Inc. | Systems, methods, and apparatus for manipulating deformable fluid vessels |
US20140264472A1 (en) | 2013-03-15 | 2014-09-18 | Life Technologies Corporation | Chemical sensor with consistent sensor surface areas |
JP2016521350A (en) | 2013-03-15 | 2016-07-21 | フリューダイム・コーポレイション | Method and apparatus for analysis of defined multicellular combinations |
US10569225B2 (en) * | 2013-03-28 | 2020-02-25 | National Research Council Of Canada | Peristaltic pump microfluidic separator |
WO2014182847A1 (en) | 2013-05-07 | 2014-11-13 | Micronics, Inc. | Device for preparation and analysis of nucleic acids |
WO2014182844A1 (en) | 2013-05-07 | 2014-11-13 | Micronics, Inc. | Microfluidic devices and methods for performing serum separation and blood cross-matching |
CA2911303C (en) | 2013-05-07 | 2021-02-16 | Micronics, Inc. | Methods for preparation of nucleic acid-containing samples using clay minerals and alkaline solutions |
AU2014278537B2 (en) | 2013-06-12 | 2018-04-19 | The General Hospital Corporation | Methods, kits, and systems for multiplexed detection of target molecules and uses thereof |
GB2516675A (en) | 2013-07-29 | 2015-02-04 | Atlas Genetics Ltd | A valve which depressurises, and a valve system |
GB2516672B (en) * | 2013-07-29 | 2015-05-20 | Atlas Genetics Ltd | A system and method for expelling liquid from a fluidic cartridge |
US11901041B2 (en) | 2013-10-04 | 2024-02-13 | Bio-Rad Laboratories, Inc. | Digital analysis of nucleic acid modification |
US10410739B2 (en) | 2013-10-04 | 2019-09-10 | Life Technologies Corporation | Methods and systems for modeling phasing effects in sequencing using termination chemistry |
CA2866542A1 (en) * | 2013-10-08 | 2015-04-08 | Ponnambalam Selvaganapathy | Integrated reagentless sample preprocessing for molecular diagnostics using a nanoporous membrane based microfluidic device |
US9498778B2 (en) | 2014-11-11 | 2016-11-22 | Genmark Diagnostics, Inc. | Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system |
USD881409S1 (en) | 2013-10-24 | 2020-04-14 | Genmark Diagnostics, Inc. | Biochip cartridge |
CN105873681B (en) | 2013-11-18 | 2019-10-11 | 尹特根埃克斯有限公司 | Cartridge and instrument for sample analysis |
CN105792924A (en) | 2013-11-29 | 2016-07-20 | 皇家飞利浦有限公司 | Optical controlling of a chemical reaction |
US9476853B2 (en) | 2013-12-10 | 2016-10-25 | Life Technologies Corporation | System and method for forming microwells |
US9944977B2 (en) | 2013-12-12 | 2018-04-17 | Raindance Technologies, Inc. | Distinguishing rare variations in a nucleic acid sequence from a sample |
EP3083658B1 (en) | 2013-12-18 | 2019-05-08 | President and Fellows of Harvard College | Crp capture/detection of gram positive bacteria |
EP3090063B1 (en) | 2013-12-31 | 2019-11-06 | Bio-Rad Laboratories, Inc. | Method for detection of latent retrovirus |
WO2015179098A1 (en) | 2014-05-21 | 2015-11-26 | Integenx Inc. | Fluidic cartridge with valve mechanism |
JP2016066193A (en) * | 2014-09-24 | 2016-04-28 | 株式会社リコー | Information processing system and information processing method |
JP6740222B2 (en) | 2014-10-10 | 2020-08-12 | クアンタポール, インコーポレイテッド | Nanopore-based polymer analysis with fluorescent labels quenching each other |
WO2016060974A1 (en) | 2014-10-13 | 2016-04-21 | Life Technologies Corporation | Methods, systems, and computer-readable media for accelerated base calling |
EP3552690A1 (en) | 2014-10-22 | 2019-10-16 | IntegenX Inc. | Systems and methods for sample preparation, processing and analysis |
EP3213240B1 (en) | 2014-10-27 | 2021-01-20 | King Abdullah University Of Science And Technology | Methods and systems for identifying ligand-protein binding sites |
US10005080B2 (en) | 2014-11-11 | 2018-06-26 | Genmark Diagnostics, Inc. | Instrument and cartridge for performing assays in a closed sample preparation and reaction system employing electrowetting fluid manipulation |
US9598722B2 (en) | 2014-11-11 | 2017-03-21 | Genmark Diagnostics, Inc. | Cartridge for performing assays in a closed sample preparation and reaction system |
US10364467B2 (en) | 2015-01-13 | 2019-07-30 | The Chinese University Of Hong Kong | Using size and number aberrations in plasma DNA for detecting cancer |
JP5783586B1 (en) | 2015-01-22 | 2015-09-24 | 有限会社フルイド | PCR apparatus and PCR method |
WO2016145360A1 (en) * | 2015-03-11 | 2016-09-15 | Hexna Corp. | Portable dna analysis machine |
US10509008B2 (en) | 2015-04-29 | 2019-12-17 | Taiwan Semiconductor Manufacturing Co., Ltd. | Biological device and biosensing method thereof |
US9709524B2 (en) | 2015-05-15 | 2017-07-18 | Taiwan Semiconductor Manufacturing Co., Ltd. | Integrated circuit device with adaptations for multiplexed biosensing |
WO2017004250A1 (en) | 2015-06-29 | 2017-01-05 | Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State University | Systems and methods for continuous flow digital droplet polymerase chain reaction bioanalysis |
JP6882782B2 (en) | 2015-08-04 | 2021-06-02 | デューク ユニバーシティ | Genetically encoded, essentially chaotic delivery stealth polymers and how to use them |
US10435457B2 (en) | 2015-08-06 | 2019-10-08 | President And Fellows Of Harvard College | Microbe-binding molecules and uses thereof |
US10647981B1 (en) | 2015-09-08 | 2020-05-12 | Bio-Rad Laboratories, Inc. | Nucleic acid library generation methods and compositions |
US11054367B2 (en) | 2015-10-12 | 2021-07-06 | The Regents Of The University Of California | Spectroscopy imaging and analysis of live cells |
US10228367B2 (en) | 2015-12-01 | 2019-03-12 | ProteinSimple | Segmented multi-use automated assay cartridge |
US10161901B2 (en) | 2015-12-07 | 2018-12-25 | Taiwan Semiconductor Manufacturing Co., Ltd. | Dual gate biologically sensitive field effect transistor |
US11752213B2 (en) | 2015-12-21 | 2023-09-12 | Duke University | Surfaces having reduced non-specific binding and antigenicity |
WO2017119382A1 (en) * | 2016-01-05 | 2017-07-13 | 日本板硝子株式会社 | Reaction treatment device, reaction treatment container, and reaction treatment method |
EP3313978B1 (en) * | 2016-01-08 | 2024-02-28 | Hewlett-Packard Development Company, L.P. | Polymerase chain reaction device |
EP3248681A1 (en) * | 2016-05-23 | 2017-11-29 | ETH Zurich | Microfluidic device defining an array of sample chambers |
US11467156B2 (en) | 2016-06-01 | 2022-10-11 | Duke University | Nonfouling biosensors |
US10409227B2 (en) * | 2016-08-03 | 2019-09-10 | Texas Instruments Incorporated | Temperature gradient in microfabricated sensor cavity |
JP2020500517A (en) | 2016-11-28 | 2020-01-16 | アリゾナ ボード オブ リージェンツ オン ビハーフ オブ アリゾナ ステート ユニバーシティ | Systems and methods relating to continuous flow droplet reactions |
US11648200B2 (en) | 2017-01-12 | 2023-05-16 | Duke University | Genetically encoded lipid-polypeptide hybrid biomaterials that exhibit temperature triggered hierarchical self-assembly |
WO2018213320A1 (en) | 2017-05-15 | 2018-11-22 | Duke University | Recombinant production of hybrid lipid-biopolymer materials that self-assemble and encapsulate agents |
US11912970B2 (en) | 2017-05-15 | 2024-02-27 | The University Of Chicago | Universal microfluidic culture system to analyze and control cell dynamics |
WO2019006374A1 (en) | 2017-06-30 | 2019-01-03 | Duke University | Order and disorder as a design principle for stimuli-responsive biopolymer networks |
GB201717103D0 (en) * | 2017-10-18 | 2017-11-29 | Tech Partnership Plc | Fluid ejector system |
US11680957B2 (en) | 2018-02-12 | 2023-06-20 | Hewlett-Packard Development Company, L.P. | Microfluidic flow sensor |
WO2019156711A1 (en) * | 2018-02-12 | 2019-08-15 | Hewlett-Packard Development Company, L.P. | Devices to measure flow rates with movable elements |
KR20210006337A (en) | 2018-03-15 | 2021-01-18 | 크립토스 바이오테크놀로지스, 인코포레이티드 | Methods and systems for performing heat assisted biochemical reactions |
US20210016281A1 (en) * | 2018-03-22 | 2021-01-21 | Nikon Corporation | Fluid device |
CN112236218B (en) | 2018-04-02 | 2022-04-26 | 滴管公司 | System and method for continuous flow emulsion processing |
US10898871B2 (en) | 2018-07-02 | 2021-01-26 | International Business Machines Corporation | Micro electrical mechanical system (MEMS) multiplexing mixing |
JP7430701B2 (en) | 2018-07-23 | 2024-02-13 | ディーエヌエー スクリプト | Large-scale parallel enzymatic synthesis of nucleic acid strands |
EP3829622A4 (en) | 2018-08-02 | 2022-05-11 | Duke University | Dual agonist fusion proteins |
WO2020081342A1 (en) * | 2018-10-19 | 2020-04-23 | President And Fellows Of Harvard College | Smart toilet paper |
US20210154673A1 (en) * | 2018-11-13 | 2021-05-27 | The University Of North Carolina At Chapel Hill | Analysis systems with microfluidic devices, microfluidic devices and related methods |
CN113423503A (en) * | 2018-12-10 | 2021-09-21 | 康比纳提公司 | Microfluidic array for sample digitization |
US11268091B2 (en) | 2018-12-13 | 2022-03-08 | Dna Script Sas | Direct oligonucleotide synthesis on cells and biomolecules |
JP2022515912A (en) | 2019-01-03 | 2022-02-22 | ディーエヌエー スクリプト | One-pot synthesis of oligonucleotide sets |
US11609208B2 (en) * | 2019-04-12 | 2023-03-21 | Western Digital Technologies, Inc. | Devices and methods for molecule detection based on thermal stabilities of magnetic nanoparticles |
US11512314B2 (en) | 2019-07-12 | 2022-11-29 | Duke University | Amphiphilic polynucleotides |
CN111019804B (en) * | 2019-12-17 | 2024-04-05 | 东莞市东阳光诊断产品有限公司 | Nucleic acid amplification device, system and method |
WO2022040495A1 (en) * | 2020-08-21 | 2022-02-24 | Duke University | Microfluidic assay device |
TW202214866A (en) * | 2020-09-30 | 2022-04-16 | 富佳生技股份有限公司 | Heating structure, detection chip, nucleic acid detection disc and nucleic acid detection device |
CN116888273A (en) * | 2020-10-19 | 2023-10-13 | 富默乐国际控股有限公司 | Device with fluid channel geometry for sample-to-result PCR analysis and method of use thereof |
CN114690812A (en) * | 2020-12-31 | 2022-07-01 | 中元汇吉生物技术股份有限公司 | Temperature control unit, temperature control unit and temperature control device |
JP2024502618A (en) | 2021-01-08 | 2024-01-22 | セラノーム, インコーポレイテッド | Devices and methods for analyzing biological samples |
NL2027654B1 (en) * | 2021-02-08 | 2022-09-09 | Nutcracker Therapeutics Inc | Methods for manufacturing a syntetic template |
CN114225980A (en) * | 2021-12-10 | 2022-03-25 | 广西科技大学 | Micro-fluidic chip for molecular cycle adsorption and continuous optical detection and method for detecting multiple nucleic acid samples by using micro-fluidic chip |
CN115181655A (en) * | 2022-07-07 | 2022-10-14 | 四川华汉三创生物科技有限公司 | Microfluidic card box for PCR amplification and hybridization reaction and use method thereof |
WO2024035754A1 (en) * | 2022-08-10 | 2024-02-15 | Nutcracker Therapeutics, Inc. | Apparatuses and methods for measuring dna/rna production in biochips |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990015070A1 (en) * | 1989-06-07 | 1990-12-13 | Affymax Technologies N.V. | Very large scale immobilized peptide synthesis |
WO1992016657A1 (en) * | 1991-03-13 | 1992-10-01 | E.I. Du Pont De Nemours And Company | Method of identifying a nucleotide present at a defined position in a nucleic acid |
US5802856A (en) * | 1996-07-31 | 1998-09-08 | Stanford University | Multizone bake/chill thermal cycling module |
US6018616A (en) * | 1998-02-23 | 2000-01-25 | Applied Materials, Inc. | Thermal cycling module and process using radiant heat |
WO2001001025A2 (en) * | 1999-06-28 | 2001-01-04 | California Institute Of Technology | Microfabricated elastomeric valve and pump systems |
US6227809B1 (en) * | 1995-03-09 | 2001-05-08 | University Of Washington | Method for making micropumps |
Family Cites Families (317)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2656508A (en) | 1949-08-27 | 1953-10-20 | Wallace H Coulter | Means for counting particles suspended in a fluid |
US3570515A (en) * | 1969-06-19 | 1971-03-16 | Foxboro Co | Aminar stream cross-flow fluid diffusion logic gate |
NL7102074A (en) * | 1971-02-17 | 1972-08-21 | ||
US3839176A (en) | 1971-03-08 | 1974-10-01 | North American Rockwell | Method and apparatus for removing contaminants from liquids |
US3984307A (en) | 1973-03-05 | 1976-10-05 | Bio/Physics Systems, Inc. | Combined particle sorter and segregation indicator |
US3915652A (en) | 1973-08-16 | 1975-10-28 | Samuel Natelson | Means for transferring a liquid in a capillary open at both ends to an analyzing system |
FR2287606A1 (en) * | 1974-10-08 | 1976-05-07 | Pegourie Jean Pierre | PNEUMATIC LOGIC CIRCUITS AND THEIR INTEGRATED CIRCUITS |
US4018565A (en) | 1975-10-17 | 1977-04-19 | The Foxboro Company | Automatic process titration system |
JPS5941169B2 (en) | 1975-12-25 | 1984-10-05 | シチズン時計株式会社 | Elastomer |
US4153855A (en) | 1977-12-16 | 1979-05-08 | The United States Of America As Represented By The Secretary Of The Army | Method of making a plate having a pattern of microchannels |
US4245673A (en) | 1978-03-01 | 1981-01-20 | La Telemechanique Electrique | Pneumatic logic circuit |
US4245873A (en) * | 1979-03-08 | 1981-01-20 | Markowitz Isral J | Adjustably positionable electrical outlet |
US4373527B1 (en) | 1979-04-27 | 1995-06-27 | Univ Johns Hopkins | Implantable programmable medication infusion system |
US4344064A (en) * | 1979-12-06 | 1982-08-10 | Western Electric Co., Inc. | Article carrying a distinctive mark |
US4434704A (en) * | 1980-04-14 | 1984-03-06 | Halliburton Company | Hydraulic digital stepper actuator |
GB2097692B (en) | 1981-01-10 | 1985-05-22 | Shaw Stewart P D | Combining chemical reagents |
US4399219A (en) | 1981-01-29 | 1983-08-16 | Massachusetts Institute Of Technology | Process for isolating microbiologically active material |
US4707237A (en) * | 1982-09-09 | 1987-11-17 | Ciba Corning Diagnostics Corp. | System for identification of cells by electrophoresis |
US4575681A (en) | 1982-11-12 | 1986-03-11 | Teleco Oilfield Services Inc. | Insulating and electrode structure for a drill string |
US4662710A (en) | 1982-12-03 | 1987-05-05 | Amp Incorporated | Method and apparatus for breaking an optical fiber |
US4585209A (en) | 1983-10-27 | 1986-04-29 | Harry E. Aine | Miniature valve and method of making same |
US4581624A (en) | 1984-03-01 | 1986-04-08 | Allied Corporation | Microminiature semiconductor valve |
GB8408529D0 (en) | 1984-04-03 | 1984-05-16 | Health Lab Service Board | Concentration of biological particles |
US6040166A (en) | 1985-03-28 | 2000-03-21 | Roche Molecular Systems, Inc. | Kits for amplifying and detecting nucleic acid sequences, including a probe |
JPH07104855B2 (en) | 1985-03-28 | 1995-11-13 | インターナショナル・ビジネス・マシーンズ・コーポレーション | Numerical simulation device |
US4963498A (en) | 1985-08-05 | 1990-10-16 | Biotrack | Capillary flow device |
US5140161A (en) | 1985-08-05 | 1992-08-18 | Biotrack | Capillary flow device |
US4675300A (en) | 1985-09-18 | 1987-06-23 | The Board Of Trustees Of The Leland Stanford Junior University | Laser-excitation fluorescence detection electrokinetic separation |
US5088515A (en) * | 1989-05-01 | 1992-02-18 | Kamen Dean L | Valve system with removable fluid interface |
US4786165A (en) | 1986-07-10 | 1988-11-22 | Toa Medical Electronics Co., Ltd. | Flow cytometry and apparatus therefor |
US5525464A (en) | 1987-04-01 | 1996-06-11 | Hyseq, Inc. | Method of sequencing by hybridization of oligonucleotide probes |
EP0314469B1 (en) | 1987-10-27 | 1993-06-23 | Fujitsu Limited | Process and apparatus for preparation of single crystal of biopolymer |
US4936465A (en) | 1987-12-07 | 1990-06-26 | Zoeld Tibor | Method and apparatus for fast, reliable, and environmentally safe dispensing of fluids, gases and individual particles of a suspension through pressure control at well defined parts of a closed flow-through system |
US5002867A (en) | 1988-04-25 | 1991-03-26 | Macevicz Stephen C | Nucleic acid sequence determination by multiple mixed oligonucleotide probes |
US5354695A (en) | 1992-04-08 | 1994-10-11 | Leedy Glenn J | Membrane dielectric isolation IC fabrication |
US4908112A (en) | 1988-06-16 | 1990-03-13 | E. I. Du Pont De Nemours & Co. | Silicon semiconductor wafer for analyzing micronic biological samples |
US4965743A (en) | 1988-07-14 | 1990-10-23 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Discrete event simulation tool for analysis of qualitative models of continuous processing system |
US4898582A (en) | 1988-08-09 | 1990-02-06 | Pharmetrix Corporation | Portable infusion device assembly |
US5032381A (en) | 1988-12-20 | 1991-07-16 | Tropix, Inc. | Chemiluminescence-based static and flow cytometry |
US4992312A (en) | 1989-03-13 | 1991-02-12 | Dow Corning Wright Corporation | Methods of forming permeation-resistant, silicone elastomer-containing composite laminates and devices produced thereby |
CH679555A5 (en) | 1989-04-11 | 1992-03-13 | Westonbridge Int Ltd | |
ES2061042T3 (en) | 1989-06-14 | 1994-12-01 | Westonbridge Int Ltd | PERFECTED MICROPUMP. |
US5100627A (en) | 1989-11-30 | 1992-03-31 | The Regents Of The University Of California | Chamber for the optical manipulation of microscopic particles |
US5171132A (en) | 1989-12-27 | 1992-12-15 | Seiko Epson Corporation | Two-valve thin plate micropump |
US5091652A (en) * | 1990-01-12 | 1992-02-25 | The Regents Of The University Of California | Laser excited confocal microscope fluorescence scanner and method |
JPH03239770A (en) | 1990-02-16 | 1991-10-25 | Kansai Paint Co Ltd | Resin composition for cationic electrodeposition coating |
EP0517760A1 (en) | 1990-02-24 | 1992-12-16 | University Of Hertfordshire | Biorheological measurement |
DE4006152A1 (en) | 1990-02-27 | 1991-08-29 | Fraunhofer Ges Forschung | MICROMINIATURIZED PUMP |
US5126022A (en) | 1990-02-28 | 1992-06-30 | Soane Tecnologies, Inc. | Method and device for moving molecules by the application of a plurality of electrical fields |
US5770029A (en) * | 1996-07-30 | 1998-06-23 | Soane Biosciences | Integrated electrophoretic microdevices |
US5750015A (en) | 1990-02-28 | 1998-05-12 | Soane Biosciences | Method and device for moving molecules by the application of a plurality of electrical fields |
US5858188A (en) | 1990-02-28 | 1999-01-12 | Aclara Biosciences, Inc. | Acrylic microchannels and their use in electrophoretic applications |
US5096388A (en) | 1990-03-22 | 1992-03-17 | The Charles Stark Draper Laboratory, Inc. | Microfabricated pump |
US5867399A (en) | 1990-04-06 | 1999-02-02 | Lsi Logic Corporation | System and method for creating and validating structural description of electronic system from higher-level and behavior-oriented description |
GB9008044D0 (en) | 1990-04-09 | 1990-06-06 | Hatfield Polytechnic Higher Ed | Microfabricated device for biological cell sorting |
SE470347B (en) | 1990-05-10 | 1994-01-31 | Pharmacia Lkb Biotech | Microstructure for fluid flow systems and process for manufacturing such a system |
DE69106240T2 (en) | 1990-07-02 | 1995-05-11 | Seiko Epson Corp | Micropump and method of making a micropump. |
US6074818A (en) | 1990-08-24 | 2000-06-13 | The University Of Tennessee Research Corporation | Fingerprinting of nucleic acids, products and methods |
CA2069894C (en) | 1990-08-31 | 2001-04-24 | Harald T. G. Van Lintel | Valve equipped with a position detector and a micropump incorporating said valve |
WO1992019960A1 (en) | 1991-05-09 | 1992-11-12 | Nanophore, Inc. | Methods for the electrophoretic separation of nucleic acids and other linear macromolecules in gel media with restrictive pore diameters |
DE4119955C2 (en) | 1991-06-18 | 2000-05-31 | Danfoss As | Miniature actuator |
US5164558A (en) * | 1991-07-05 | 1992-11-17 | Massachusetts Institute Of Technology | Micromachined threshold pressure switch and method of manufacture |
JP3328300B2 (en) * | 1991-07-18 | 2002-09-24 | アイシン精機株式会社 | Fluid control device |
US5307186A (en) | 1991-08-09 | 1994-04-26 | Sharp Kabushiki Kaisha | Liquid crystal light valve having capability of providing high-contrast image |
DE4127405C2 (en) | 1991-08-19 | 1996-02-29 | Fraunhofer Ges Forschung | Process for the separation of mixtures of microscopic dielectric particles suspended in a liquid or a gel and device for carrying out the process |
DE4143343C2 (en) | 1991-09-11 | 1994-09-22 | Fraunhofer Ges Forschung | Microminiaturized, electrostatically operated micromembrane pump |
US5265327A (en) | 1991-09-13 | 1993-11-30 | Faris Sadeg M | Microchannel plate technology |
WO1993006239A1 (en) | 1991-09-24 | 1993-04-01 | Keygene N.V. | Selective restriction fragment amplification: a general method for dna fingerprinting |
US6569382B1 (en) | 1991-11-07 | 2003-05-27 | Nanogen, Inc. | Methods apparatus for the electronic, homogeneous assembly and fabrication of devices |
US5846708A (en) | 1991-11-19 | 1998-12-08 | Massachusetts Institiute Of Technology | Optical and electrical methods and apparatus for molecule detection |
GB2264296B (en) | 1992-02-07 | 1995-06-28 | Zortech Int | Microporous thermal insulation material |
US5558998A (en) | 1992-02-25 | 1996-09-24 | The Regents Of The Univ. Of California | DNA fragment sizing and sorting by laser-induced fluorescence |
GB2264496B (en) | 1992-02-25 | 1995-10-25 | Us Energy | Sizing of fragments from a nucleic acid sequence |
JPH05236997A (en) | 1992-02-28 | 1993-09-17 | Hitachi Ltd | Chip for catching polynucleotide |
JP2740705B2 (en) | 1992-04-08 | 1998-04-15 | 本田技研工業株式会社 | Fluid torque converter characteristic simulation method and apparatus |
US5637469A (en) | 1992-05-01 | 1997-06-10 | Trustees Of The University Of Pennsylvania | Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems |
US5486335A (en) | 1992-05-01 | 1996-01-23 | Trustees Of The University Of Pennsylvania | Analysis based on flow restriction |
US5498392A (en) | 1992-05-01 | 1996-03-12 | Trustees Of The University Of Pennsylvania | Mesoscale polynucleotide amplification device and method |
US5726026A (en) * | 1992-05-01 | 1998-03-10 | Trustees Of The University Of Pennsylvania | Mesoscale sample preparation device and systems for determination and processing of analytes |
US5304487A (en) * | 1992-05-01 | 1994-04-19 | Trustees Of The University Of Pennsylvania | Fluid handling in mesoscale analytical devices |
DE4220077A1 (en) | 1992-06-19 | 1993-12-23 | Bosch Gmbh Robert | Micro-pump for delivery of gases - uses working chamber warmed by heating element and controlled by silicon wafer valves. |
US5284568A (en) | 1992-07-17 | 1994-02-08 | E. I. Du Pont De Nemours And Company | Disposable cartridge for ion selective electrode sensors |
US5629147A (en) | 1992-07-17 | 1997-05-13 | Aprogenex, Inc. | Enriching and identifying fetal cells in maternal blood for in situ hybridization |
US5639423A (en) | 1992-08-31 | 1997-06-17 | The Regents Of The University Of Calfornia | Microfabricated reactor |
US5364742A (en) | 1992-09-21 | 1994-11-15 | International Business Machines Corporation | Micro-miniature structures and method of fabrication thereof |
US5477474A (en) | 1992-10-29 | 1995-12-19 | Altera Corporation | Computer logic simulation with dynamic modeling |
EP0600608B1 (en) | 1992-10-29 | 1999-12-22 | Altera Corporation | Design verification method for programmable logic design |
JP2812629B2 (en) * | 1992-11-25 | 1998-10-22 | 宇宙開発事業団 | Crystal growth cell |
US5290240A (en) | 1993-02-03 | 1994-03-01 | Pharmetrix Corporation | Electrochemical controlled dispensing assembly and method for selective and controlled delivery of a dispensing fluid |
US5604098A (en) | 1993-03-24 | 1997-02-18 | Molecular Biology Resources, Inc. | Methods and materials for restriction endonuclease applications |
US5400741A (en) | 1993-05-21 | 1995-03-28 | Medical Foundation Of Buffalo, Inc. | Device for growing crystals |
EP0700485B1 (en) * | 1993-05-27 | 1997-08-13 | Fraunhofer-Gesellschaft Zur Förderung Der Angewandten Forschung E.V. | Microvalve |
SE501713C2 (en) | 1993-09-06 | 1995-05-02 | Pharmacia Biosensor Ab | Diaphragm-type valve, especially for liquid handling blocks with micro-flow channels |
US5837832A (en) | 1993-06-25 | 1998-11-17 | Affymetrix, Inc. | Arrays of nucleic acid probes on biological chips |
US5642015A (en) | 1993-07-14 | 1997-06-24 | The University Of British Columbia | Elastomeric micro electro mechanical systems |
US5417235A (en) | 1993-07-28 | 1995-05-23 | Regents Of The University Of Michigan | Integrated microvalve structures with monolithic microflow controller |
US5659171A (en) | 1993-09-22 | 1997-08-19 | Northrop Grumman Corporation | Micro-miniature diaphragm pump for the low pressure pumping of gases |
DE69431994T2 (en) | 1993-10-04 | 2003-10-30 | Res Int Inc | MICRO-MACHINED FLUID TREATMENT DEVICE WITH FILTER AND CONTROL VALVE |
US5512131A (en) | 1993-10-04 | 1996-04-30 | President And Fellows Of Harvard College | Formation of microstamped patterns on surfaces and derivative articles |
CH689836A5 (en) | 1994-01-14 | 1999-12-15 | Westonbridge Int Ltd | Micropump. |
EP0670489A3 (en) | 1994-03-03 | 1996-03-06 | Ciba Geigy Ag | Apparatus and process for separating fluid substances. |
US5580523A (en) | 1994-04-01 | 1996-12-03 | Bard; Allen J. | Integrated chemical synthesizers |
US5587081A (en) | 1994-04-26 | 1996-12-24 | Jet-Tech, Inc. | Thermophilic aerobic waste treatment process |
DE69527585T2 (en) | 1994-06-08 | 2003-04-03 | Affymetrix Inc | Method and device for packaging chips |
US5807522A (en) | 1994-06-17 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for fabricating microarrays of biological samples |
US6001229A (en) | 1994-08-01 | 1999-12-14 | Lockheed Martin Energy Systems, Inc. | Apparatus and method for performing microfluidic manipulations for chemical analysis |
DE4433894A1 (en) | 1994-09-22 | 1996-03-28 | Fraunhofer Ges Forschung | Method and device for controlling a micropump |
EP0706004B1 (en) | 1994-10-07 | 2003-08-06 | Bayer Corporation | Relief valve |
US5496009A (en) | 1994-10-07 | 1996-03-05 | Bayer Corporation | Valve |
US5695934A (en) * | 1994-10-13 | 1997-12-09 | Lynx Therapeutics, Inc. | Massively parallel sequencing of sorted polynucleotides |
DE4437274C2 (en) | 1994-10-18 | 1998-11-05 | Inst Chemo Biosensorik | Analyte selective sensor |
US5571410A (en) | 1994-10-19 | 1996-11-05 | Hewlett Packard Company | Fully integrated miniaturized planar liquid sample handling and analysis device |
US5641400A (en) | 1994-10-19 | 1997-06-24 | Hewlett-Packard Company | Use of temperature control devices in miniaturized planar column devices and miniaturized total analysis systems |
US5500071A (en) | 1994-10-19 | 1996-03-19 | Hewlett-Packard Company | Miniaturized planar columns in novel support media for liquid phase analysis |
DE4438785C2 (en) | 1994-10-24 | 1996-11-07 | Wita Gmbh Wittmann Inst Of Tec | Microchemical reaction and analysis unit |
US5788468A (en) | 1994-11-03 | 1998-08-04 | Memstek Products, Llc | Microfabricated fluidic devices |
US5585069A (en) | 1994-11-10 | 1996-12-17 | David Sarnoff Research Center, Inc. | Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis |
CA2204912C (en) * | 1994-11-10 | 2005-01-04 | David Sarnoff Research Center, Inc. | Liquid distribution system |
US5632876A (en) | 1995-06-06 | 1997-05-27 | David Sarnoff Research Center, Inc. | Apparatus and methods for controlling fluid flow in microchannels |
US5665070A (en) | 1995-01-19 | 1997-09-09 | I-Flow Corporation | Infusion pump with magnetic bag compression |
AU5171696A (en) | 1995-02-27 | 1996-09-18 | Ely Michael Rabani | Device, compounds, algorithms, and methods of molecular characterization and manipulation with molecular parallelism |
JP3094880B2 (en) | 1995-03-01 | 2000-10-03 | 住友金属工業株式会社 | Method for controlling crystallization of organic compound and solid state element for controlling crystallization used therein |
US5775371A (en) | 1995-03-08 | 1998-07-07 | Abbott Laboratories | Valve control |
US5876187A (en) | 1995-03-09 | 1999-03-02 | University Of Washington | Micropumps with fixed valves |
US6140045A (en) | 1995-03-10 | 2000-10-31 | Meso Scale Technologies | Multi-array, multi-specific electrochemiluminescence testing |
US5608519A (en) | 1995-03-20 | 1997-03-04 | Gourley; Paul L. | Laser apparatus and method for microscopic and spectroscopic analysis and processing of biological cells |
US5661222A (en) | 1995-04-13 | 1997-08-26 | Dentsply Research & Development Corp. | Polyvinylsiloxane impression material |
US5757482A (en) | 1995-04-20 | 1998-05-26 | Perseptive Biosystems, Inc. | Module for optical detection in microscale fluidic analyses |
US5976822A (en) * | 1995-05-18 | 1999-11-02 | Coulter International Corp. | Method and reagent for monitoring apoptosis and distinguishing apoptosis from necrosis |
DE19520298A1 (en) | 1995-06-02 | 1996-12-05 | Bayer Ag | Sorting device for biological cells or viruses |
US5716852A (en) | 1996-03-29 | 1998-02-10 | University Of Washington | Microfabricated diffusion-based chemical sensor |
AU6541596A (en) | 1995-06-16 | 1997-01-15 | University Of Washington | Microfabricated differential extraction device and method |
US5589136A (en) | 1995-06-20 | 1996-12-31 | Regents Of The University Of California | Silicon-based sleeve devices for chemical reactions |
US5856174A (en) | 1995-06-29 | 1999-01-05 | Affymetrix, Inc. | Integrated nucleic acid diagnostic device |
US6057103A (en) | 1995-07-18 | 2000-05-02 | Diversa Corporation | Screening for novel bioactivities |
US5958672A (en) | 1995-07-18 | 1999-09-28 | Diversa Corporation | Protein activity screening of clones having DNA from uncultivated microorganisms |
US5812394A (en) | 1995-07-21 | 1998-09-22 | Control Systems International | Object-oriented computer program, system, and method for developing control schemes for facilities |
US5872010A (en) | 1995-07-21 | 1999-02-16 | Northeastern University | Microscale fluid handling system |
JPH0943251A (en) | 1995-08-03 | 1997-02-14 | Olympus Optical Co Ltd | Dispenser |
CA2183478C (en) * | 1995-08-17 | 2004-02-24 | Stephen A. Carter | Digital gas metering system using tri-stable and bi-stable solenoids |
US6130098A (en) | 1995-09-15 | 2000-10-10 | The Regents Of The University Of Michigan | Moving microdroplets |
US5726751A (en) | 1995-09-27 | 1998-03-10 | University Of Washington | Silicon microchannel optical flow cytometer |
US6132580A (en) * | 1995-09-28 | 2000-10-17 | The Regents Of The University Of California | Miniature reaction chamber and devices incorporating same |
JP3563175B2 (en) | 1995-10-17 | 2004-09-08 | シチズン時計株式会社 | Composite display clock with EL illumination |
US5871697A (en) | 1995-10-24 | 1999-02-16 | Curagen Corporation | Method and apparatus for identifying, classifying, or quantifying DNA sequences in a sample without sequencing |
US5958344A (en) | 1995-11-09 | 1999-09-28 | Sarnoff Corporation | System for liquid distribution |
JPH09149799A (en) | 1995-11-30 | 1997-06-10 | Hitachi Ltd | Analysis or detection of nucleic acid and analyser or inspection device of nucleic acid |
US5705018A (en) | 1995-12-13 | 1998-01-06 | Hartley; Frank T. | Micromachined peristaltic pump |
KR100207410B1 (en) | 1995-12-19 | 1999-07-15 | 전주범 | Fabrication method for lightpath modulation device |
US5978822A (en) | 1995-12-29 | 1999-11-02 | Atmel Corporation | Circuit for rotating, left shifting, or right shifting bits |
US5863502A (en) * | 1996-01-24 | 1999-01-26 | Sarnoff Corporation | Parallel reaction cassette and associated devices |
US5660370A (en) | 1996-03-07 | 1997-08-26 | Integrated Fludics, Inc. | Valve with flexible sheet member and two port non-flexing backer member |
US5885470A (en) | 1997-04-14 | 1999-03-23 | Caliper Technologies Corporation | Controlled fluid transport in microfabricated polymeric substrates |
US5942443A (en) * | 1996-06-28 | 1999-08-24 | Caliper Technologies Corporation | High throughput screening assay systems in microscale fluidic devices |
US5867266A (en) * | 1996-04-17 | 1999-02-02 | Cornell Research Foundation, Inc. | Multiple optical channels for chemical analysis |
US5726404A (en) | 1996-05-31 | 1998-03-10 | University Of Washington | Valveless liquid microswitch |
FR2749663B1 (en) * | 1996-06-07 | 1998-07-31 | Bio Merieux | SINGLE USE ANALYSIS CARD COMPRISING A LIQUID FLOW CONDUIT |
US5763239A (en) | 1996-06-18 | 1998-06-09 | Diversa Corporation | Production and use of normalized DNA libraries |
NZ333346A (en) | 1996-06-28 | 2000-03-27 | Caliper Techn Corp | High-throughput screening assay systems in microscale fluidic devices |
US5779868A (en) | 1996-06-28 | 1998-07-14 | Caliper Technologies Corporation | Electropipettor and compensation means for electrophoretic bias |
WO1998000705A1 (en) | 1996-06-28 | 1998-01-08 | Caliper Technologies Corporation | Electropipettor and compensation means for electrophoretic bias |
US5800690A (en) | 1996-07-03 | 1998-09-01 | Caliper Technologies Corporation | Variable control of electroosmotic and/or electrophoretic forces within a fluid-containing structure via electrical forces |
CA2259395C (en) | 1996-07-15 | 2002-03-05 | Sumitomo Metal Industries, Ltd. | Equipment for crystal growth and crystal-growing method using the same |
US5699157A (en) | 1996-07-16 | 1997-12-16 | Caliper Technologies Corp. | Fourier detection of species migrating in a microchannel |
EP0956364A1 (en) | 1996-07-26 | 1999-11-17 | Genzyme Corporation | Whole cell assay |
US6074827A (en) | 1996-07-30 | 2000-06-13 | Aclara Biosciences, Inc. | Microfluidic method for nucleic acid purification and processing |
US6136212A (en) * | 1996-08-12 | 2000-10-24 | The Regents Of The University Of Michigan | Polymer-based micromachining for microfluidic devices |
AU4164597A (en) | 1996-08-26 | 1998-03-19 | Princeton University | Reversibly sealable microstructure sorting devices |
US5832165A (en) * | 1996-08-28 | 1998-11-03 | University Of Utah Research Foundation | Composite waveguide for solid phase binding assays |
DE69709377T2 (en) | 1996-09-04 | 2002-08-14 | Scandinavian Micro Biodevices | MICROFLOWING SYSTEM FOR PARTICLE ANALYSIS AND SEPARATION |
US5738799A (en) | 1996-09-12 | 1998-04-14 | Xerox Corporation | Method and materials for fabricating an ink-jet printhead |
US6221654B1 (en) * | 1996-09-25 | 2001-04-24 | California Institute Of Technology | Method and apparatus for analysis and sorting of polynucleotides based on size |
US5854684A (en) | 1996-09-26 | 1998-12-29 | Sarnoff Corporation | Massively parallel detection |
US5858187A (en) | 1996-09-26 | 1999-01-12 | Lockheed Martin Energy Systems, Inc. | Apparatus and method for performing electrodynamic focusing on a microchip |
US5876817A (en) | 1996-10-31 | 1999-03-02 | Minnesota Mining And Manufacturing Company | Adhesive clip |
US6056428A (en) | 1996-11-12 | 2000-05-02 | Invention Machine Corporation | Computer based system for imaging and analyzing an engineering object system and indicating values of specific design changes |
US5839722A (en) | 1996-11-26 | 1998-11-24 | Xerox Corporation | Paper handling system having embedded control structures |
US5971355A (en) | 1996-11-27 | 1999-10-26 | Xerox Corporation | Microdevice valve structures to fluid control |
US5804384A (en) | 1996-12-06 | 1998-09-08 | Vysis, Inc. | Devices and methods for detecting multiple analytes in samples |
US5815306A (en) | 1996-12-24 | 1998-09-29 | Xerox Corporation | "Eggcrate" substrate for a twisting ball display |
WO1998035376A1 (en) | 1997-01-27 | 1998-08-13 | California Institute Of Technology | Mems electrospray nozzle for mass spectroscopy |
US6376971B1 (en) | 1997-02-07 | 2002-04-23 | Sri International | Electroactive polymer electrodes |
DE69825601T2 (en) * | 1997-02-12 | 2005-04-28 | Chan, Eugene Y, Brookline | METHOD FOR THE ANALYSIS OF POLYMERS |
US6117634A (en) | 1997-03-05 | 2000-09-12 | The Reagents Of The University Of Michigan | Nucleic acid sequencing and mapping |
JP2001521622A (en) | 1997-04-04 | 2001-11-06 | カリパー テクノロジーズ コーポレイション | Closed-loop biochemical analyzer |
US6235471B1 (en) | 1997-04-04 | 2001-05-22 | Caliper Technologies Corp. | Closed-loop biochemical analyzers |
AU727083B2 (en) | 1997-04-25 | 2000-11-30 | Caliper Life Sciences, Inc. | Microfluidic devices incorporating improved channel geometries |
JP2002503336A (en) | 1997-05-16 | 2002-01-29 | アルバータ リサーチ カウンシル | Micro-distribution system and method of using the same |
US5876946A (en) * | 1997-06-03 | 1999-03-02 | Pharmacopeia, Inc. | High-throughput assay |
US5922604A (en) * | 1997-06-05 | 1999-07-13 | Gene Tec Corporation | Thin reaction chambers for containing and handling liquid microvolumes |
US5869004A (en) | 1997-06-09 | 1999-02-09 | Caliper Technologies Corp. | Methods and apparatus for in situ concentration and/or dilution of materials in microfluidic systems |
US5888778A (en) * | 1997-06-16 | 1999-03-30 | Exact Laboratories, Inc. | High-throughput screening method for identification of genetic mutations or disease-causing microorganisms using segmented primers |
US5939709A (en) | 1997-06-19 | 1999-08-17 | Ghislain; Lucien P. | Scanning probe optical microscope using a solid immersion lens |
AU8275998A (en) | 1997-06-27 | 1999-01-19 | Immunetics, Inc. | Rapid flow-through binding assay apparatus and method |
US6529612B1 (en) | 1997-07-16 | 2003-03-04 | Diversified Scientific, Inc. | Method for acquiring, storing and analyzing crystal images |
US5932799A (en) | 1997-07-21 | 1999-08-03 | Ysi Incorporated | Microfluidic analyzer module |
US6073482A (en) | 1997-07-21 | 2000-06-13 | Ysi Incorporated | Fluid flow module |
US5972639A (en) * | 1997-07-24 | 1999-10-26 | Irori | Fluorescence-based assays for measuring cell proliferation |
US6375871B1 (en) | 1998-06-18 | 2002-04-23 | 3M Innovative Properties Company | Methods of manufacturing microfluidic articles |
US5876675A (en) * | 1997-08-05 | 1999-03-02 | Caliper Technologies Corp. | Microfluidic devices and systems |
US5965410A (en) | 1997-09-02 | 1999-10-12 | Caliper Technologies Corp. | Electrical current for controlling fluid parameters in microchannels |
JP2001516573A (en) | 1997-09-18 | 2001-10-02 | スミスクライン・ビーチャム・コーポレイション | Screening method for antimicrobial compounds |
TW352471B (en) * | 1997-09-20 | 1999-02-11 | United Microelectronics Corp | Method for preventing B-P-Si glass from subsiding |
US6540895B1 (en) | 1997-09-23 | 2003-04-01 | California Institute Of Technology | Microfabricated cell sorter for chemical and biological materials |
US7214298B2 (en) | 1997-09-23 | 2007-05-08 | California Institute Of Technology | Microfabricated cell sorter |
US6833242B2 (en) | 1997-09-23 | 2004-12-21 | California Institute Of Technology | Methods for detecting and sorting polynucleotides based on size |
WO1999018438A1 (en) * | 1997-10-02 | 1999-04-15 | Aclara Biosciences, Inc. | Capillary assays involving separation of free and bound species |
US5842787A (en) * | 1997-10-09 | 1998-12-01 | Caliper Technologies Corporation | Microfluidic systems incorporating varied channel dimensions |
US5836750A (en) | 1997-10-09 | 1998-11-17 | Honeywell Inc. | Electrostatically actuated mesopump having a plurality of elementary cells |
US5958694A (en) * | 1997-10-16 | 1999-09-28 | Caliper Technologies Corp. | Apparatus and methods for sequencing nucleic acids in microfluidic systems |
US6345502B1 (en) | 1997-11-12 | 2002-02-12 | California Institute Of Technology | Micromachined parylene membrane valve and pump |
US6174675B1 (en) | 1997-11-25 | 2001-01-16 | Caliper Technologies Corp. | Electrical current for controlling fluid parameters in microchannels |
US5948227A (en) | 1997-12-17 | 1999-09-07 | Caliper Technologies Corp. | Methods and systems for performing electrophoretic molecular separations |
US6089534A (en) | 1998-01-08 | 2000-07-18 | Xerox Corporation | Fast variable flow microelectromechanical valves |
US6269846B1 (en) | 1998-01-13 | 2001-08-07 | Genetic Microsystems, Inc. | Depositing fluid specimens on substrates, resulting ordered arrays, techniques for deposition of arrays |
AU2459799A (en) * | 1998-01-20 | 1999-08-02 | Triconex, Incorporated | Two out of three voting solenoid arrangement |
US6167910B1 (en) | 1998-01-20 | 2001-01-02 | Caliper Technologies Corp. | Multi-layer microfluidic devices |
DE59905737D1 (en) * | 1998-02-11 | 2003-07-03 | Inst Physikalische Hochtech Ev | MINIATURIZED TEMPERATURE ZONES RIVER REACTOR |
US5997961A (en) | 1998-03-06 | 1999-12-07 | Battelle Memorial Institute | Method of bonding functional surface materials to substrates and applications in microtechnology and antifouling |
WO1999052633A1 (en) | 1998-04-14 | 1999-10-21 | Ivd Systems | Test cartridge with a single inlet port |
JP4269194B2 (en) | 1998-04-14 | 2009-05-27 | 日東紡績株式会社 | Low dielectric constant glass fiber |
ATE530891T1 (en) | 1998-05-22 | 2011-11-15 | California Inst Of Techn | MINIATURIZED CELL SORTER |
US6246330B1 (en) | 1998-05-29 | 2001-06-12 | Wyn Y. Nielsen | Elimination-absorber monitoring system |
JPH11352409A (en) * | 1998-06-05 | 1999-12-24 | Olympus Optical Co Ltd | Fluorescence detector |
WO2000000678A1 (en) | 1998-06-26 | 2000-01-06 | University Of Washington | Crystallization media |
US6406921B1 (en) | 1998-07-14 | 2002-06-18 | Zyomyx, Incorporated | Protein arrays for high-throughput screening |
US6576478B1 (en) | 1998-07-14 | 2003-06-10 | Zyomyx, Inc. | Microdevices for high-throughput screening of biomolecules |
US6132685A (en) * | 1998-08-10 | 2000-10-17 | Caliper Technologies Corporation | High throughput microfluidic systems and methods |
CN100435900C (en) | 1998-09-17 | 2008-11-26 | 阿德文生物科学公司 | Liquid chromatography system, chemical separating arrangement and apparatus and method for mass spectrometric analysis |
US6146842A (en) * | 1998-09-21 | 2000-11-14 | Mitotix, Inc. | High-throughput screening assays utilizing metal-chelate capture |
US6605472B1 (en) | 1998-10-09 | 2003-08-12 | The Governors Of The University Of Alberta | Microfluidic devices connected to glass capillaries with minimal dead volume |
US6637463B1 (en) | 1998-10-13 | 2003-10-28 | Biomicro Systems, Inc. | Multi-channel microfluidic system design with balanced fluid flow distribution |
US6149787A (en) | 1998-10-14 | 2000-11-21 | Caliper Technologies Corp. | External material accession systems and methods |
RU2143343C1 (en) | 1998-11-03 | 1999-12-27 | Самсунг Электроникс Ко., Лтд. | Microinjector and microinjector manufacture method |
US6541539B1 (en) | 1998-11-04 | 2003-04-01 | President And Fellows Of Harvard College | Hierarchically ordered porous oxides |
US6062261A (en) * | 1998-12-16 | 2000-05-16 | Lockheed Martin Energy Research Corporation | MicrofluIdic circuit designs for performing electrokinetic manipulations that reduce the number of voltage sources and fluid reservoirs |
US6887693B2 (en) | 1998-12-24 | 2005-05-03 | Cepheid | Device and method for lysing cells, spores, or microorganisms |
US6361671B1 (en) * | 1999-01-11 | 2002-03-26 | The Regents Of The University Of California | Microfabricated capillary electrophoresis chip and method for simultaneously detecting multiple redox labels |
US6150119A (en) * | 1999-01-19 | 2000-11-21 | Caliper Technologies Corp. | Optimized high-throughput analytical system |
ATE556149T1 (en) | 1999-02-23 | 2012-05-15 | Caliper Life Sciences Inc | MANIPULATION OF MICROPARTICLES IN MICROFLUIDIC SYSTEMS |
US6749814B1 (en) | 1999-03-03 | 2004-06-15 | Symyx Technologies, Inc. | Chemical processing microsystems comprising parallel flow microreactors and methods for using same |
US6171850B1 (en) * | 1999-03-08 | 2001-01-09 | Caliper Technologies Corp. | Integrated devices and systems for performing temperature controlled reactions and analyses |
WO2000053801A1 (en) | 1999-03-08 | 2000-09-14 | Merck Frosst Canada & Co. | Intact cell assay for protein tyrosine phosphatases |
US6500323B1 (en) | 1999-03-26 | 2002-12-31 | Caliper Technologies Corp. | Methods and software for designing microfluidic devices |
ATE357656T1 (en) | 1999-04-06 | 2007-04-15 | Univ Alabama Res Found | DEVICE FOR SCREENING CRYSTALIZATION CONDITIONS IN CRYSTAL GROWING SOLUTIONS |
US6352838B1 (en) | 1999-04-07 | 2002-03-05 | The Regents Of The Universtiy Of California | Microfluidic DNA sample preparation method and device |
US6346373B1 (en) | 1999-05-05 | 2002-02-12 | Merck Frosst Canada & Co., | Whole cell assay for cathepsin K activity |
GB9911095D0 (en) | 1999-05-13 | 1999-07-14 | Secr Defence | Microbiological test method and reagents |
US6225109B1 (en) * | 1999-05-27 | 2001-05-01 | Orchid Biosciences, Inc. | Genetic analysis device |
WO2000074751A1 (en) | 1999-06-08 | 2000-12-14 | Medical Research Group, Inc. | Method and apparatus for infusing liquids using a chemical reaction in an implanted infusion device |
US6296673B1 (en) | 1999-06-18 | 2001-10-02 | The Regents Of The University Of California | Methods and apparatus for performing array microcrystallizations |
US6899137B2 (en) | 1999-06-28 | 2005-05-31 | California Institute Of Technology | Microfabricated elastomeric valve and pump systems |
US7052545B2 (en) | 2001-04-06 | 2006-05-30 | California Institute Of Technology | High throughput screening of crystallization of materials |
US6533914B1 (en) | 1999-07-08 | 2003-03-18 | Shaorong Liu | Microfabricated injector and capillary array assembly for high-resolution and high throughput separation |
DE19933614C1 (en) | 1999-07-17 | 2000-11-30 | Moeller Gmbh | Contact system for current-limiting load switch has 2-armed contact arm carrying contact pieces cooperating with contact pieces of fixed contact rails fitted to pivot axis via elongate slot |
DE60037433T2 (en) | 1999-07-20 | 2008-12-04 | Sri International, Menlo Park | Electroactive polymer generators |
US6488872B1 (en) | 1999-07-23 | 2002-12-03 | The Board Of Trustees Of The University Of Illinois | Microfabricated devices and method of manufacturing the same |
WO2001007061A1 (en) | 1999-07-27 | 2001-02-01 | Smithkline Beecham Corporation | Whole cell assay |
US6977145B2 (en) * | 1999-07-28 | 2005-12-20 | Serono Genetics Institute S.A. | Method for carrying out a biochemical protocol in continuous flow in a microreactor |
AU6396500A (en) | 1999-08-02 | 2001-02-19 | Emerald Biostructures, Inc. | Method and system for creating a crystallization results database |
US6505125B1 (en) | 1999-09-28 | 2003-01-07 | Affymetrix, Inc. | Methods and computer software products for multiple probe gene expression analysis |
DE29917313U1 (en) * | 1999-10-01 | 2001-02-15 | Mwg Biotech Ag | Device for carrying out chemical or biological reactions |
GB9923324D0 (en) | 1999-10-01 | 1999-12-08 | Pyrosequencing Ab | Separation apparatus and method |
WO2001032930A1 (en) | 1999-11-04 | 2001-05-10 | California Institute Of Technology | Methods and apparatuses for analyzing polynucleotide sequences |
US6361958B1 (en) | 1999-11-12 | 2002-03-26 | Motorola, Inc. | Biochannel assay for hybridization with biomaterial |
CA2364381C (en) | 1999-12-22 | 2009-03-10 | Gene Logic, Inc. | Flow-thru chip cartridge, chip holder, system and method thereof |
WO2001053794A1 (en) | 2000-01-18 | 2001-07-26 | Northeastern University | Parallel sample loading and injection device for multichannel microfluidic devices |
US6866785B2 (en) | 2001-08-13 | 2005-03-15 | The Board Of Trustees Of The Leland Stanford Junior University | Photopolymerized sol-gel column and associated methods |
WO2001067369A2 (en) | 2000-03-03 | 2001-09-13 | California Institute Of Technology | Combinatorial array for nucleic acid analysis |
US6541071B1 (en) | 2000-03-23 | 2003-04-01 | Corning Incorporated | Method for fabricating supported bilayer-lipid membranes |
US6358387B1 (en) | 2000-03-27 | 2002-03-19 | Caliper Technologies Corporation | Ultra high throughput microfluidic analytical systems and methods |
AU2001251218B2 (en) | 2000-03-31 | 2006-06-29 | Perkinelmer Health Sciences, Inc. | Protein crystallization in microfluidic structures |
US6431212B1 (en) | 2000-05-24 | 2002-08-13 | Jon W. Hayenga | Valve for use in microfluidic structures |
US6645432B1 (en) | 2000-05-25 | 2003-11-11 | President & Fellows Of Harvard College | Microfluidic systems including three-dimensionally arrayed channel networks |
US7351376B1 (en) * | 2000-06-05 | 2008-04-01 | California Institute Of Technology | Integrated active flux microfluidic devices and methods |
AU2001273057A1 (en) | 2000-06-27 | 2002-01-08 | Fluidigm Corporation | A microfluidic design automation method and system |
US6885982B2 (en) | 2000-06-27 | 2005-04-26 | Fluidigm Corporation | Object oriented microfluidic design method and system |
US6627159B1 (en) | 2000-06-28 | 2003-09-30 | 3M Innovative Properties Company | Centrifugal filling of sample processing devices |
JP3542550B2 (en) | 2000-07-19 | 2004-07-14 | 本田技研工業株式会社 | Method of forming fuel cell seal |
US7054508B2 (en) * | 2000-08-03 | 2006-05-30 | Canon Kabushiki Kaisha | Data editing apparatus and method |
AU2001290879A1 (en) | 2000-09-15 | 2002-03-26 | California Institute Of Technology | Microfabricated crossflow devices and methods |
US6787339B1 (en) | 2000-10-02 | 2004-09-07 | Motorola, Inc. | Microfluidic devices having embedded metal conductors and methods of fabricating said devices |
EP1322936A2 (en) | 2000-10-03 | 2003-07-02 | California Institute Of Technology | Microfluidic devices and methods of use |
US6508988B1 (en) * | 2000-10-03 | 2003-01-21 | California Institute Of Technology | Combinatorial synthesis system |
US6827095B2 (en) | 2000-10-12 | 2004-12-07 | Nanostream, Inc. | Modular microfluidic systems |
EP1336097A4 (en) | 2000-10-13 | 2006-02-01 | Fluidigm Corp | Microfluidic device based sample injection system for analytical devices |
DE60103924T2 (en) | 2000-11-06 | 2005-07-14 | Nanostream, Inc., Pasadena | MICROFLUID FLOW RATE DEVICE |
US7232109B2 (en) | 2000-11-06 | 2007-06-19 | California Institute Of Technology | Electrostatic valves for microfluidic devices |
EP1343973B2 (en) | 2000-11-16 | 2020-09-16 | California Institute Of Technology | Apparatus and methods for conducting assays and high throughput screening |
US6951632B2 (en) | 2000-11-16 | 2005-10-04 | Fluidigm Corporation | Microfluidic devices for introducing and dispensing fluids from microfluidic systems |
US6736978B1 (en) | 2000-12-13 | 2004-05-18 | Iowa State University Research Foundation, Inc. | Method and apparatus for magnetoresistive monitoring of analytes in flow streams |
US20050196785A1 (en) | 2001-03-05 | 2005-09-08 | California Institute Of Technology | Combinational array for nucleic acid analysis |
CA2440754A1 (en) | 2001-03-12 | 2002-09-19 | Stephen Quake | Methods and apparatus for analyzing polynucleotide sequences by asynchronous base extension |
US6960437B2 (en) | 2001-04-06 | 2005-11-01 | California Institute Of Technology | Nucleic acid amplification utilizing microfluidic devices |
US6802342B2 (en) | 2001-04-06 | 2004-10-12 | Fluidigm Corporation | Microfabricated fluidic circuit elements and applications |
EP1392484B1 (en) | 2001-04-06 | 2013-06-12 | California Institute Of Technology | High throughput screening of crystalization of materials |
US6752922B2 (en) | 2001-04-06 | 2004-06-22 | Fluidigm Corporation | Microfluidic chromatography |
US6847153B1 (en) | 2001-06-13 | 2005-01-25 | The United States Of America As Represented By The Secretary Of The Navy | Polyurethane electrostriction |
US6444318B1 (en) | 2001-07-17 | 2002-09-03 | Surmodics, Inc. | Self assembling monolayer compositions |
US7075162B2 (en) | 2001-08-30 | 2006-07-11 | Fluidigm Corporation | Electrostatic/electrostrictive actuation of elastomer structures using compliant electrodes |
WO2003031066A1 (en) | 2001-10-11 | 2003-04-17 | California Institute Of Technology | Devices utilizing self-assembled gel and method of manufacture |
US6627076B2 (en) | 2001-10-19 | 2003-09-30 | Sandia National Laboratories | Compact microchannel system |
US20030175947A1 (en) | 2001-11-05 | 2003-09-18 | Liu Robin Hui | Enhanced mixing in microfluidic devices |
JP2005509883A (en) | 2001-11-15 | 2005-04-14 | アリックス,インコーポレーテッド | Sample tip |
EP1463796B1 (en) | 2001-11-30 | 2013-01-09 | Fluidigm Corporation | Microfluidic device and methods of using same |
US6893613B2 (en) | 2002-01-25 | 2005-05-17 | Bristol-Myers Squibb Company | Parallel chemistry reactor with interchangeable vessel carrying inserts |
US6581441B1 (en) | 2002-02-01 | 2003-06-24 | Perseptive Biosystems, Inc. | Capillary column chromatography process and system |
US6662818B2 (en) | 2002-02-01 | 2003-12-16 | Perseptive Biosystems, Inc. | Programmable tracking pressure regulator for control of higher pressures in microfluidic circuits |
US7312085B2 (en) | 2002-04-01 | 2007-12-25 | Fluidigm Corporation | Microfluidic particle-analysis systems |
US7059348B2 (en) | 2002-05-13 | 2006-06-13 | Fluidigm Corporation | Drug delivery system |
US7186383B2 (en) | 2002-09-27 | 2007-03-06 | Ast Management Inc. | Miniaturized fluid delivery and analysis system |
JP5695287B2 (en) | 2002-10-02 | 2015-04-01 | カリフォルニア インスティテュート オブ テクノロジー | Nucleic acid analysis of microfluids |
CA2503789A1 (en) | 2002-11-08 | 2004-05-27 | Irm, Llc | Apparatus and methods to process substrate surface features |
US7604965B2 (en) | 2003-04-03 | 2009-10-20 | Fluidigm Corporation | Thermal reaction device and method for using the same |
US7476363B2 (en) | 2003-04-03 | 2009-01-13 | Fluidigm Corporation | Microfluidic devices and methods of using same |
US7413712B2 (en) | 2003-08-11 | 2008-08-19 | California Institute Of Technology | Microfluidic rotary flow reactor matrix |
US7407799B2 (en) | 2004-01-16 | 2008-08-05 | California Institute Of Technology | Microfluidic chemostat |
-
2002
- 2002-04-05 US US10/118,466 patent/US6960437B2/en not_active Expired - Fee Related
- 2002-04-05 WO PCT/US2002/010815 patent/WO2002081729A2/en not_active Application Discontinuation
- 2002-04-05 EP EP02763966A patent/EP1384022A4/en not_active Withdrawn
- 2002-04-05 AU AU2002307152A patent/AU2002307152A1/en not_active Abandoned
-
2005
- 2005-05-19 US US11/133,805 patent/US7833708B2/en not_active Expired - Fee Related
-
2010
- 2010-11-16 US US12/947,774 patent/US8486636B2/en not_active Expired - Lifetime
-
2013
- 2013-07-02 US US13/934,052 patent/US8936764B2/en not_active Expired - Fee Related
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990015070A1 (en) * | 1989-06-07 | 1990-12-13 | Affymax Technologies N.V. | Very large scale immobilized peptide synthesis |
WO1992016657A1 (en) * | 1991-03-13 | 1992-10-01 | E.I. Du Pont De Nemours And Company | Method of identifying a nucleotide present at a defined position in a nucleic acid |
US6227809B1 (en) * | 1995-03-09 | 2001-05-08 | University Of Washington | Method for making micropumps |
US5802856A (en) * | 1996-07-31 | 1998-09-08 | Stanford University | Multizone bake/chill thermal cycling module |
US6018616A (en) * | 1998-02-23 | 2000-01-25 | Applied Materials, Inc. | Thermal cycling module and process using radiant heat |
WO2001001025A2 (en) * | 1999-06-28 | 2001-01-04 | California Institute Of Technology | Microfabricated elastomeric valve and pump systems |
Non-Patent Citations (1)
Title |
---|
See also references of EP1384022A2 * |
Cited By (119)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9926521B2 (en) | 2000-06-27 | 2018-03-27 | Fluidigm Corporation | Microfluidic particle-analysis systems |
US10509018B2 (en) | 2000-11-16 | 2019-12-17 | California Institute Of Technology | Apparatus and methods for conducting assays and high throughput screening |
US7887753B2 (en) | 2000-11-16 | 2011-02-15 | California Institute Of Technology | Apparatus and methods for conducting assays and high throughput screening |
US8273574B2 (en) | 2000-11-16 | 2012-09-25 | California Institute Of Technology | Apparatus and methods for conducting assays and high throughput screening |
US9176137B2 (en) | 2000-11-16 | 2015-11-03 | California Institute Of Technology | Apparatus and methods for conducting assays and high throughput screening |
US8455258B2 (en) | 2000-11-16 | 2013-06-04 | California Insitute Of Technology | Apparatus and methods for conducting assays and high throughput screening |
US8673645B2 (en) | 2000-11-16 | 2014-03-18 | California Institute Of Technology | Apparatus and methods for conducting assays and high throughput screening |
US8486636B2 (en) | 2001-04-06 | 2013-07-16 | California Institute Of Technology | Nucleic acid amplification using microfluidic devices |
US8936764B2 (en) | 2001-04-06 | 2015-01-20 | California Institute Of Technology | Nucleic acid amplification using microfluidic devices |
US7833708B2 (en) | 2001-04-06 | 2010-11-16 | California Institute Of Technology | Nucleic acid amplification using microfluidic devices |
US7329535B2 (en) | 2001-11-10 | 2008-02-12 | Samsung Electronics Co., Ltd. | Apparatus for circulating carrier fluid |
CN100335609C (en) * | 2001-11-10 | 2007-09-05 | 三星电子株式会社 | Apparatus for circulating carrier fluid |
WO2003042410A1 (en) * | 2001-11-10 | 2003-05-22 | Samsung Electronics Co., Ltd. | Apparatus for circulating carrier fluid |
US9643178B2 (en) | 2001-11-30 | 2017-05-09 | Fluidigm Corporation | Microfluidic device with reaction sites configured for blind filling |
US8163492B2 (en) | 2001-11-30 | 2012-04-24 | Fluidign Corporation | Microfluidic device and methods of using same |
US7820427B2 (en) | 2001-11-30 | 2010-10-26 | Fluidigm Corporation | Microfluidic device and methods of using same |
US8658418B2 (en) | 2002-04-01 | 2014-02-25 | Fluidigm Corporation | Microfluidic particle-analysis systems |
US9714443B2 (en) | 2002-09-25 | 2017-07-25 | California Institute Of Technology | Microfabricated structure having parallel and orthogonal flow channels controlled by row and column multiplexors |
US8871446B2 (en) | 2002-10-02 | 2014-10-28 | California Institute Of Technology | Microfluidic nucleic acid analysis |
US9579650B2 (en) | 2002-10-02 | 2017-02-28 | California Institute Of Technology | Microfluidic nucleic acid analysis |
US10940473B2 (en) | 2002-10-02 | 2021-03-09 | California Institute Of Technology | Microfluidic nucleic acid analysis |
US10328428B2 (en) | 2002-10-02 | 2019-06-25 | California Institute Of Technology | Apparatus for preparing cDNA libraries from single cells |
USRE43365E1 (en) | 2003-03-14 | 2012-05-08 | Lawrence Livermore National Security, Llc | Apparatus for chemical amplification based on fluid partitioning in an immiscible liquid |
USRE47080E1 (en) | 2003-03-14 | 2018-10-09 | Lawrence Livermore National Security, Llc | Chemical amplification based on fluid partitioning |
USRE48788E1 (en) | 2003-03-14 | 2021-10-26 | Lawrence Livermore National Security, Llc | Chemical amplification based on fluid partitioning |
USRE41780E1 (en) | 2003-03-14 | 2010-09-28 | Lawrence Livermore National Security, Llc | Chemical amplification based on fluid partitioning in an immiscible liquid |
EP1464399A3 (en) * | 2003-04-02 | 2005-11-16 | Hitachi, Ltd. | Nucleic-acid amplifying apparatus and nucleic-acid amplifying method |
EP1464399A2 (en) * | 2003-04-02 | 2004-10-06 | Hitachi, Ltd. | Nucleic-acid amplifying apparatus and nucleic-acid amplifying method |
US10131934B2 (en) | 2003-04-03 | 2018-11-20 | Fluidigm Corporation | Thermal reaction device and method for using the same |
WO2005094981A1 (en) * | 2004-03-29 | 2005-10-13 | Agilent Technologies, Inc. | Cyclic pcr system |
EP1796824A4 (en) * | 2004-05-02 | 2016-10-19 | Fluidigm Corp | Thermal reaction device and method for using the same |
EP3640342A1 (en) | 2004-05-13 | 2020-04-22 | Nanobiosym, Inc. | Nano-pcr: methods and devices for nucleic acid amplification and detection |
US8632973B2 (en) | 2004-05-13 | 2014-01-21 | Nanobiosym, Inc. | Nano-PCR: methods and devices for nucleic acid amplification and detection |
US8048378B2 (en) | 2004-06-07 | 2011-11-01 | Fluidigm Corporation | Optical lens system and method for microfluidic devices |
US7906072B2 (en) | 2004-06-07 | 2011-03-15 | Fluidigm Corporation | Optical lens system and method for microfluidic devices |
US8512640B2 (en) | 2004-06-07 | 2013-08-20 | Fluidigm Corporation | Optical lens system and method for microfluidic devices |
US10745748B2 (en) | 2004-06-07 | 2020-08-18 | Fluidigm Corporation | Optical lens system and method for microfluidic devices |
US9663821B2 (en) | 2004-06-07 | 2017-05-30 | Fluidigm Corporation | Optical lens system and method for microfluidic devices |
US7307802B2 (en) | 2004-06-07 | 2007-12-11 | Fluidigm Corporation | Optical lens system and method for microfluidic devices |
US10106846B2 (en) | 2004-06-07 | 2018-10-23 | Fluidigm Corporation | Optical lens system and method for microfluidic devices |
US9234237B2 (en) | 2004-06-07 | 2016-01-12 | Fluidigm Corporation | Optical lens system and method for microfluidic devices |
US8721968B2 (en) | 2004-06-07 | 2014-05-13 | Fluidigm Corporation | Optical lens system and method for microfluidic devices |
US8926905B2 (en) | 2004-06-07 | 2015-01-06 | Fluidigm Corporation | Optical lens system and method for microfluidic devices |
US7588672B2 (en) | 2004-06-07 | 2009-09-15 | Fluidigm Corporation | Optical lens system and method for microfluidic devices |
GB2433259A (en) * | 2005-11-30 | 2007-06-20 | Deltadot Ltd | Nucleic acid amplification method and microfluidic apparatus therefore |
US8420017B2 (en) | 2006-02-28 | 2013-04-16 | Fluidigm Corporation | Microfluidic reaction apparatus for high throughput screening |
US7815868B1 (en) | 2006-02-28 | 2010-10-19 | Fluidigm Corporation | Microfluidic reaction apparatus for high throughput screening |
US11807892B2 (en) | 2006-04-21 | 2023-11-07 | Nanobiosym, Inc. | Single-molecule platform for drug discovery: methods and apparatuses for drug discovery, including discovery of anticancer and antiviral agents |
US9862984B2 (en) | 2006-04-21 | 2018-01-09 | Nanobiosym, Inc. | Single-molecule platform for drug discovery: methods and apparatuses for drug discovery, including discovery of anticancer and antiviral agents |
CN101680013A (en) * | 2007-06-11 | 2010-03-24 | 和光纯药工业株式会社 | microchip large-volume pcr with integrated real-time ce detection |
WO2008154036A1 (en) | 2007-06-11 | 2008-12-18 | Wako Pure Chemical Industries, Ltd. | Microchip large-volume pcr with integrated real-time ce detection |
EP2717041A1 (en) * | 2007-06-11 | 2014-04-09 | Wako Pure Chemical Industries, Ltd. | Microchip large volume polymerase chain reaction (PCR) with integrated real-time capillary electrophoresis detection |
EP2152893A1 (en) * | 2007-06-11 | 2010-02-17 | Wako Pure Chemical Industries, Ltd. | Microchip large-volume pcr with integrated real-time ce detection |
EP2152893A4 (en) * | 2007-06-11 | 2010-12-08 | Wako Pure Chem Ind Ltd | Microchip large-volume pcr with integrated real-time ce detection |
EP2008717A2 (en) | 2007-06-28 | 2008-12-31 | Sony Corporation | Reaction device with accurate temperature control |
EP2008717A3 (en) * | 2007-06-28 | 2012-11-07 | Sony Corporation | Reaction device with accurate temperature control |
GB2452057A (en) * | 2007-08-23 | 2009-02-25 | Shaw Stewart P D | A microfluidic device for thermal assays |
GB2452101A (en) * | 2007-08-23 | 2009-02-25 | Shaw Stewart P D | A microfluidic device for thermal shift assays |
EP2286247A2 (en) * | 2008-04-23 | 2011-02-23 | Bioscale, Inc. | Method and apparatus for analyte processing |
EP2285491A1 (en) * | 2008-04-25 | 2011-02-23 | Claros Diagnostics, Inc. | Flow control in microfluidic systems |
US9623384B2 (en) | 2008-09-23 | 2017-04-18 | Bio-Rad Laboratories, Inc. | System for transporting emulsions from an array to a detector |
US11633739B2 (en) | 2008-09-23 | 2023-04-25 | Bio-Rad Laboratories, Inc. | Droplet-based assay system |
US9636682B2 (en) | 2008-09-23 | 2017-05-02 | Bio-Rad Laboratories, Inc. | System for generating droplets—instruments and cassette |
US10258988B2 (en) | 2008-09-23 | 2019-04-16 | Bio-Rad Laboratories, Inc. | Device for generating droplets |
US9649635B2 (en) | 2008-09-23 | 2017-05-16 | Bio-Rad Laboratories, Inc. | System for generating droplets with push-back to remove oil |
US9492797B2 (en) | 2008-09-23 | 2016-11-15 | Bio-Rad Laboratories, Inc. | System for detection of spaced droplets |
US9764322B2 (en) | 2008-09-23 | 2017-09-19 | Bio-Rad Laboratories, Inc. | System for generating droplets with pressure monitoring |
US10512910B2 (en) | 2008-09-23 | 2019-12-24 | Bio-Rad Laboratories, Inc. | Droplet-based analysis method |
US11130128B2 (en) | 2008-09-23 | 2021-09-28 | Bio-Rad Laboratories, Inc. | Detection method for a target nucleic acid |
US10258989B2 (en) | 2008-09-23 | 2019-04-16 | Bio-Rad Laboratories, Inc. | Method of making a device for generating droplets |
US11612892B2 (en) | 2008-09-23 | 2023-03-28 | Bio-Rad Laboratories, Inc. | Method of performing droplet-based assays |
US10279350B2 (en) | 2008-09-23 | 2019-05-07 | Bio-Rad Laboratories, Inc. | Method of generating droplets |
US11130134B2 (en) | 2008-09-23 | 2021-09-28 | Bio-Rad Laboratories, Inc. | Method of performing droplet-based assays |
US9101933B2 (en) | 2008-10-10 | 2015-08-11 | University Of Hull | Microfluidic apparatus and method for DNA extraction, amplification and analysis |
US11795494B2 (en) | 2009-04-02 | 2023-10-24 | Fluidigm Corporation | Multi-primer amplification method for barcoding of target nucleic acids |
CN103952288A (en) * | 2009-04-02 | 2014-07-30 | 弗卢伊蒂格姆公司 | Multi-primer amplification method for barcoding of target nucleic acids |
US10344318B2 (en) | 2009-04-02 | 2019-07-09 | Fluidigm Corporation | Multi-primer amplification method for barcoding of target nucleic acids |
US9677119B2 (en) | 2009-04-02 | 2017-06-13 | Fluidigm Corporation | Multi-primer amplification method for tagging of target nucleic acids |
EP2789694A1 (en) * | 2009-04-02 | 2014-10-15 | Fluidigm Corporation | Microfluidic device with reaction product recovery system |
JP2013503605A (en) * | 2009-09-01 | 2013-02-04 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | Devices and methods for microarray selection |
US10677693B2 (en) | 2009-09-02 | 2020-06-09 | Bio-Rad Laboratories, Inc. | System for mixing fluids by coalescence of multiple emulsions |
US10166522B2 (en) | 2009-09-02 | 2019-01-01 | Bio-Rad Laboratories, Inc. | System for mixing fluids by coalescence of multiple emulsions |
WO2011045288A3 (en) * | 2009-10-13 | 2011-06-30 | Iti Scotland Limited | Microfluidic mixer and method |
WO2011045288A2 (en) | 2009-10-13 | 2011-04-21 | Iti Scotland Limited | Microfluidic mixer |
US11060136B2 (en) | 2010-03-02 | 2021-07-13 | Bio-Rad Laboratories, Inc. | Emulsion chemistry for encapsulated droplets |
US11866771B2 (en) | 2010-03-02 | 2024-01-09 | Bio-Rad Laboratories, Inc. | Emulsion chemistry for encapsulated droplets |
US10378048B2 (en) | 2010-03-02 | 2019-08-13 | Bio-Rad Laboratories, Inc. | Emulsion chemistry for encapsulated droplets |
US10099219B2 (en) | 2010-03-25 | 2018-10-16 | Bio-Rad Laboratories, Inc. | Device for generating droplets |
US10744506B2 (en) | 2010-03-25 | 2020-08-18 | Bio-Rad Laboratories, Inc. | Device for generating droplets |
US10272432B2 (en) | 2010-03-25 | 2019-04-30 | Bio-Rad Laboratories, Inc. | Device for generating droplets |
US10590386B2 (en) | 2010-06-13 | 2020-03-17 | Insitute Of Biophysics, Chinese Academy Of Sciences | Methods and compositions for preparing cardiomyocytes from stem cells and uses thereof |
US9089844B2 (en) | 2010-11-01 | 2015-07-28 | Bio-Rad Laboratories, Inc. | System for forming emulsions |
US10190115B2 (en) | 2011-04-25 | 2019-01-29 | Bio-Rad Laboratories, Inc. | Methods and compositions for nucleic acid analysis |
US11939573B2 (en) | 2011-04-25 | 2024-03-26 | Bio-Rad Laboratories, Inc. | Methods and compositions for nucleic acid analysis |
US10760073B2 (en) | 2011-04-25 | 2020-09-01 | Bio-Rad Laboratories, Inc. | Methods and compositions for nucleic acid analysis |
US9885034B2 (en) | 2011-04-25 | 2018-02-06 | Bio-Rad Laboratories, Inc. | Methods and compositions for nucleic acid analysis |
US9074204B2 (en) | 2011-05-20 | 2015-07-07 | Fluidigm Corporation | Nucleic acid encoding reactions |
US10501786B2 (en) | 2011-05-20 | 2019-12-10 | Fluidigm Corporation | Nucleic acid encoding reactions |
EP2846913A4 (en) * | 2012-05-07 | 2016-01-27 | Capitalbio Corp | Microfluidic devices for multi-index biochemical detection |
WO2013166857A1 (en) | 2012-05-07 | 2013-11-14 | Capitalbio Corporation | Microfluidic devices for multi-index biochemical detection |
US10758903B2 (en) | 2012-05-07 | 2020-09-01 | Capitalbio Corporation | Microfluidic devices for multi-index biochemical detection |
US9840732B2 (en) | 2012-05-21 | 2017-12-12 | Fluidigm Corporation | Single-particle analysis of particle populations |
US11339371B2 (en) | 2012-07-23 | 2022-05-24 | Institute Of Biophysics, Chinese Academy Of Sciences | Method for inducing pluripotent stem cells to differentiate into ventricular myocytes in vitro |
US10933417B2 (en) | 2013-03-15 | 2021-03-02 | Nanobiosym, Inc. | Systems and methods for mobile device analysis of nucleic acids and proteins |
EP3051293A4 (en) * | 2013-09-25 | 2017-11-22 | The University of Tokyo | Solution mixer, fluid device, and solution mixing method |
US11642636B2 (en) | 2013-09-25 | 2023-05-09 | The University Of Tokyo | Solution mixer, fluidic device, and solution mixing method |
WO2015162060A1 (en) * | 2014-04-25 | 2015-10-29 | Robert Bosch Gmbh | Microfluidic device and method for analysing a sample of biological material |
US11365439B2 (en) | 2014-07-16 | 2022-06-21 | Dynabind Gmbh | Method for identifying high-affinity complexes made of two ligands and one receptor, device for implementing the method and self-assembling chemical library for use in the method |
WO2016008822A3 (en) * | 2014-07-16 | 2016-05-19 | Technische Universität Dresden | Method for identifying high-affinity complexes of two ligands and a receptor, device for carrying out the method and self-assemblying chemical library for use with said method |
US11857940B2 (en) | 2015-12-16 | 2024-01-02 | Fluidigm Corporation | High-level multiplex amplification |
US11117113B2 (en) | 2015-12-16 | 2021-09-14 | Fluidigm Corporation | High-level multiplex amplification |
EP3181229A1 (en) * | 2015-12-17 | 2017-06-21 | Euroimmun Medizinische Labordiagnostika AG | Analytical device for carrying out a pcr reaction |
CN108541225B (en) * | 2016-01-08 | 2020-10-23 | 高丽大学校产学协力团 | Apparatus for point-of-care nucleic acid amplification measurement using surface measurement techniques |
CN108541225A (en) * | 2016-01-08 | 2018-09-14 | 高丽大学校产学协力团 | Instant nucleic acid amplification measuring device based on surface measurement sensing |
EP3401015A4 (en) * | 2016-01-08 | 2019-12-11 | Korea University Research and Business Foundation | Surface measurement sensing-based real time nucleic acid amplification measuring device |
US11192106B2 (en) | 2016-06-06 | 2021-12-07 | Nikon Corporation | Fluidic device, system, method of detecting sample material and method of purifying sample material |
US10953403B2 (en) | 2016-10-07 | 2021-03-23 | Boehringer Ingelheim Vetmedica Gmbh | Method and analysis system for testing a sample |
WO2018065102A1 (en) * | 2016-10-07 | 2018-04-12 | Boehringer Ingelheim Vetmedica Gmbh | Method and analysis system for testing a sample |
JP2019537706A (en) * | 2016-10-07 | 2019-12-26 | ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハーBoehringer Ingelheim Vetmedica GmbH | Method and analysis system for testing a sample |
Also Published As
Publication number | Publication date |
---|---|
US20120009663A1 (en) | 2012-01-12 |
EP1384022A2 (en) | 2004-01-28 |
US7833708B2 (en) | 2010-11-16 |
US8936764B2 (en) | 2015-01-20 |
WO2002081729A3 (en) | 2002-12-05 |
US6960437B2 (en) | 2005-11-01 |
EP1384022A4 (en) | 2004-08-04 |
US20140141498A1 (en) | 2014-05-22 |
US20050221373A1 (en) | 2005-10-06 |
AU2002307152A1 (en) | 2002-10-21 |
US20030008308A1 (en) | 2003-01-09 |
US8486636B2 (en) | 2013-07-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US8936764B2 (en) | Nucleic acid amplification using microfluidic devices | |
US10131934B2 (en) | Thermal reaction device and method for using the same | |
JP4355210B2 (en) | Microfluidic device and method of using microfluidic device | |
CA2521171C (en) | Microfluidic devices and methods of using same | |
US7691333B2 (en) | Microfluidic device and methods of using same | |
US8420017B2 (en) | Microfluidic reaction apparatus for high throughput screening | |
US8007746B2 (en) | Microfluidic devices and methods of using same | |
US20080292504A1 (en) | Thermal Reaction Device and Method for Using the Same | |
EP2371453A1 (en) | Microfluidic device | |
CA2807591C (en) | Microfluidic devices and methods of using same |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG US UZ VN YU ZA ZM ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
AK | Designated states |
Kind code of ref document: A3 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG US UZ VN YU ZA ZM ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A3 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
WWE | Wipo information: entry into national phase |
Ref document number: 2002763966 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 2002763966 Country of ref document: EP |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
NENP | Non-entry into the national phase |
Ref country code: JP |
|
WWW | Wipo information: withdrawn in national office |
Country of ref document: JP |
|
WWW | Wipo information: withdrawn in national office |
Ref document number: 2002763966 Country of ref document: EP |