WO2002083310A3 - Microfluidic metering systems and methods - Google Patents

Microfluidic metering systems and methods Download PDF

Info

Publication number
WO2002083310A3
WO2002083310A3 PCT/US2001/031790 US0131790W WO02083310A3 WO 2002083310 A3 WO2002083310 A3 WO 2002083310A3 US 0131790 W US0131790 W US 0131790W WO 02083310 A3 WO02083310 A3 WO 02083310A3
Authority
WO
WIPO (PCT)
Prior art keywords
fluid
microfluidic
metering
methods
metered
Prior art date
Application number
PCT/US2001/031790
Other languages
French (fr)
Other versions
WO2002083310A8 (en
WO2002083310A2 (en
Inventor
Stephen D O'connor
Christoph D Karp
Marci Pezzuto
Eugene Dantsker
Original Assignee
Nanostream Inc
Stephen D O'connor
Christoph D Karp
Marci Pezzuto
Eugene Dantsker
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2001/012244 external-priority patent/WO2001078893A2/en
Application filed by Nanostream Inc, Stephen D O'connor, Christoph D Karp, Marci Pezzuto, Eugene Dantsker filed Critical Nanostream Inc
Priority to AU2002213115A priority Critical patent/AU2002213115A1/en
Publication of WO2002083310A2 publication Critical patent/WO2002083310A2/en
Publication of WO2002083310A3 publication Critical patent/WO2002083310A3/en
Publication of WO2002083310A8 publication Critical patent/WO2002083310A8/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/08—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0605—Metering of fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0621—Control of the sequence of chambers filled or emptied
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0673—Handling of plugs of fluid surrounded by immiscible fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0874—Three dimensional network
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries

Abstract

Microfluidic devices capable of metering fluid flow are provided. Devices and methods for trunk-branch metering of fluid plugs in which one or more branch channels of defined volume are metered from a bulk fluid are described. Also described are the metering of at least one discrete plug by selecting the supply conditions of a first and a second fluid to a microfluidic channel. The first fluid may be a liquid and the second fluid a gas. Reduced-area channel segments are provided to assist with metering one or more discrete fluid plugs. In another aspect, a microfluidic volume is metered by filling a microfluidic chamber with fluid, sealing an inlet channel, and then extracting the fluid.
PCT/US2001/031790 2001-04-13 2001-10-12 Microfluidic metering systems and methods WO2002083310A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002213115A AU2002213115A1 (en) 2001-04-13 2001-10-12 Microfluidic metering systems and methods

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
USPCT/US01/12244 2001-04-13
PCT/US2001/012244 WO2001078893A2 (en) 2000-04-14 2001-04-13 Fluidic impedances in microfluidic system
US30352001P 2001-07-07 2001-07-07
US60/303,520 2001-07-07

Publications (3)

Publication Number Publication Date
WO2002083310A2 WO2002083310A2 (en) 2002-10-24
WO2002083310A3 true WO2002083310A3 (en) 2003-01-23
WO2002083310A8 WO2002083310A8 (en) 2003-05-01

Family

ID=26680460

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/031790 WO2002083310A2 (en) 2001-04-13 2001-10-12 Microfluidic metering systems and methods

Country Status (2)

Country Link
AU (1) AU2002213115A1 (en)
WO (1) WO2002083310A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6919058B2 (en) 2001-08-28 2005-07-19 Gyros Ab Retaining microfluidic microcavity and other microfluidic structures
US6845787B2 (en) * 2002-02-23 2005-01-25 Nanostream, Inc. Microfluidic multi-splitter
JP2005533651A (en) * 2002-07-26 2005-11-10 アプレラ コーポレイション Microchannel design features that facilitate fluid movement by centripetal force
US7041258B2 (en) 2002-07-26 2006-05-09 Applera Corporation Micro-channel design features that facilitate centripetal fluid transfer
WO2006005923A1 (en) * 2004-07-08 2006-01-19 Norgren Limited Liquid dispensing system
DE102005016509A1 (en) * 2005-04-09 2006-10-12 Boehringer Ingelheim Microparts Gmbh Apparatus for assaying a liquid sample comprises reaction chambers containing immobilized reagents, each connected to an assay chamber so that liquid can be transferred by centrifugal force
DE102005016508A1 (en) * 2005-04-09 2006-10-12 Boehringer Ingelheim Microparts Gmbh Apparatus for assaying a liquid sample comprises reaction chambers containing immobilized reagents, each connected to an assay chamber so that liquid can be transferred by centrifugal force
JP4837725B2 (en) 2005-04-09 2011-12-14 ベーリンガー インゲルハイム マイクロパーツ ゲゼルシャフト ミット ベシュレンクテル ハフツング Sample liquid inspection apparatus and method
DE102005042601A1 (en) * 2005-04-09 2006-10-12 Boehringer Ingelheim Microparts Gmbh Enzyme-linked immunosorbent assay (ELISA) process and assembly has a grid array of micro-dimension liquid holders and passages
EP1946830B1 (en) * 2005-11-07 2019-04-03 Konica Minolta Medical & Graphic, Inc. Microreactor
DE102010061910B4 (en) * 2010-11-24 2016-04-28 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Microfluidic device and method of making same
GB201216454D0 (en) * 2012-09-14 2012-10-31 Carclo Technical Plastics Ltd Sample metering device
WO2015026911A1 (en) * 2013-08-23 2015-02-26 Daktari Diagnostics, Inc. Microfluidic metering of fluids
CN109954522A (en) * 2017-12-22 2019-07-02 郑州达诺生物技术有限公司 More fluid passage lateral chromatography quantitative testing devices and preparation method

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3471262A (en) * 1965-12-03 1969-10-07 Ceskoslovenska Akademie Ved Method and means for exactly sectionalizing a flow of liquid in a capillary tubing
US3756459A (en) * 1971-01-12 1973-09-04 Damon Corp Method and apparatus for metering fluid utilizing pressure differentials
US4259291A (en) * 1979-07-13 1981-03-31 Technicon Instruments Corporation Metering device
EP0107631A2 (en) * 1982-09-28 1984-05-02 Bifok Ab Integrated microconduits for continuous flow analysis
US4676274A (en) * 1985-02-28 1987-06-30 Brown James F Capillary flow control
US5834314A (en) * 1994-11-07 1998-11-10 Abbott Laboratories Method and apparatus for metering a fluid
WO1999017093A1 (en) * 1997-09-26 1999-04-08 The Regents Of The University Of Michigan Moving microdroplets
US5942443A (en) * 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
WO1999042805A1 (en) * 1998-02-18 1999-08-26 Orchid Biosciences, Inc. Device for delivering defined volumes
WO2000021666A1 (en) * 1998-10-14 2000-04-20 Caliper Technologies Corp. External material accession systems and methods

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3471262A (en) * 1965-12-03 1969-10-07 Ceskoslovenska Akademie Ved Method and means for exactly sectionalizing a flow of liquid in a capillary tubing
US3756459A (en) * 1971-01-12 1973-09-04 Damon Corp Method and apparatus for metering fluid utilizing pressure differentials
US4259291A (en) * 1979-07-13 1981-03-31 Technicon Instruments Corporation Metering device
EP0107631A2 (en) * 1982-09-28 1984-05-02 Bifok Ab Integrated microconduits for continuous flow analysis
US4676274A (en) * 1985-02-28 1987-06-30 Brown James F Capillary flow control
US5834314A (en) * 1994-11-07 1998-11-10 Abbott Laboratories Method and apparatus for metering a fluid
US5942443A (en) * 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
WO1999017093A1 (en) * 1997-09-26 1999-04-08 The Regents Of The University Of Michigan Moving microdroplets
WO1999042805A1 (en) * 1998-02-18 1999-08-26 Orchid Biosciences, Inc. Device for delivering defined volumes
WO2000021666A1 (en) * 1998-10-14 2000-04-20 Caliper Technologies Corp. External material accession systems and methods

Also Published As

Publication number Publication date
WO2002083310A8 (en) 2003-05-01
AU2002213115A1 (en) 2002-10-28
WO2002083310A2 (en) 2002-10-24

Similar Documents

Publication Publication Date Title
WO2002083310A8 (en) Microfluidic metering systems and methods
WO2008127818A3 (en) Method of pumping fluid through a microfluidic device
WO2004112866A3 (en) Fluid handling device and method of making same
MY122718A (en) Gas storage and dispensing system comprising regulator interiorly disposed in fluid containment vessel and adjustable in situ therein.
DE60207708D1 (en) MICROFLUIDING SYSTEMS FOR COMBINING DISKRETER FLUID VOLUME
WO2005037706A3 (en) Fluid injection system
PL1658130T3 (en) Mixing in microfluidic devices
WO2003000416A3 (en) Microfluidic system including a virtual wall fluid interface port for interfacing fluids with the microfluidic system
WO2005022058A3 (en) Portable water cooler with bagged fluids
ATE473051T1 (en) MICROFLUIDIC ARRANGEMENT FOR DOSING LIQUIDS
WO2005037350A3 (en) Internal fluid connector for establishing a fluid connection
DE60018584D1 (en) PUMP PREVENTION DEVICE
WO2005089326A3 (en) Closed system and method for the sampling and testing of fluid
AU2003210387A8 (en) Microfluid system
WO2004024371A3 (en) Molten metal pressure pour furnace and metering valve
WO2009078107A1 (en) Dispensing device
AUPS229802A0 (en) Apparatus for mixing and/or testing small volumes of fluids
WO2006065520A3 (en) Atmospheric pressure ionization with optimized drying gas flow
WO2009154801A3 (en) Seal-retaining valve for fluid metering device
EP1649911A3 (en) Solid phase extraction
NO332958B1 (en) Plug device and method using the same
WO2006127661A3 (en) Method and system for performing an interfacial reaction in a microfluidic device
WO2004106861A3 (en) Multiphase flowmeter
HK1110927A1 (en) Fluid pump
DK1303313T3 (en) Methods for dispensing measured amounts of hyperpolarized noble gas and associated devices

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PH PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PH PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WR Later publication of a revised version of an international search report
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP