WO2002087438A3 - Closed loop neuromodulation for supperssion of epileptic activity - Google Patents

Closed loop neuromodulation for supperssion of epileptic activity Download PDF

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Publication number
WO2002087438A3
WO2002087438A3 PCT/US2002/010995 US0210995W WO02087438A3 WO 2002087438 A3 WO2002087438 A3 WO 2002087438A3 US 0210995 W US0210995 W US 0210995W WO 02087438 A3 WO02087438 A3 WO 02087438A3
Authority
WO
WIPO (PCT)
Prior art keywords
supperssion
occurrence
closed loop
neurological
epileptic activity
Prior art date
Application number
PCT/US2002/010995
Other languages
French (fr)
Other versions
WO2002087438A2 (en
Inventor
Wytse Wadman
Frans L H Gielen
Original Assignee
Medtronic Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medtronic Inc filed Critical Medtronic Inc
Priority to AT02747811T priority Critical patent/ATE296576T1/en
Priority to DE60204451T priority patent/DE60204451T2/en
Priority to EP02747811A priority patent/EP1385426B1/en
Publication of WO2002087438A2 publication Critical patent/WO2002087438A2/en
Publication of WO2002087438A3 publication Critical patent/WO2002087438A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A61B5/369—Electroencephalography [EEG]
    • A61B5/377—Electroencephalography [EEG] using evoked responses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/40—Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4076—Diagnosing or monitoring particular conditions of the nervous system
    • A61B5/4094—Diagnosing or monitoring seizure diseases, e.g. epilepsy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36082—Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease

Abstract

A system and method for predicting the likelihood of occurrence of an impending neurological episode. Electrical stimuli are delivered to a structure of the brain. Response field potentials evoked by the stimuli are sensed. Analysis of these field potentials allows for predictions as to the occurrence of an impending, but not yet occurring, neurological disorder. In one example, a measurement of change in response pulses is used to determine a level of interconnectivity in the structures of the brain. The level of functional interconnectivity is used in predicting the occurrence of the neurological event. An example of such a neurological event includes an epileptic seizure.
PCT/US2002/010995 2001-04-27 2002-04-05 Closed loop neuromodulation for supperssion of epileptic activity WO2002087438A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AT02747811T ATE296576T1 (en) 2001-04-27 2002-04-05 DETERMINATION OF NEUROLOGICAL CONDITIONS USING STIMULUS EVOCATED POTENTIALS
DE60204451T DE60204451T2 (en) 2001-04-27 2002-04-05 DETERMINATION OF NEUROLOGICAL CONDITIONS BY MEANS OF IRRITANT POTENTIALS
EP02747811A EP1385426B1 (en) 2001-04-27 2002-04-05 Detection of neurological disorders using evoked response potentials

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/842,813 2001-04-27
US09/842,813 US6671555B2 (en) 2001-04-27 2001-04-27 Closed loop neuromodulation for suppression of epileptic activity

Publications (2)

Publication Number Publication Date
WO2002087438A2 WO2002087438A2 (en) 2002-11-07
WO2002087438A3 true WO2002087438A3 (en) 2003-11-27

Family

ID=25288290

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/010995 WO2002087438A2 (en) 2001-04-27 2002-04-05 Closed loop neuromodulation for supperssion of epileptic activity

Country Status (5)

Country Link
US (2) US6671555B2 (en)
EP (1) EP1385426B1 (en)
AT (1) ATE296576T1 (en)
DE (1) DE60204451T2 (en)
WO (1) WO2002087438A2 (en)

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