WO2002087687A1 - Mikrokontaktstruktur zur implantation bei einem säugetier, insbesondere bei einem menschen - Google Patents
Mikrokontaktstruktur zur implantation bei einem säugetier, insbesondere bei einem menschen Download PDFInfo
- Publication number
- WO2002087687A1 WO2002087687A1 PCT/EP2001/004865 EP0104865W WO02087687A1 WO 2002087687 A1 WO2002087687 A1 WO 2002087687A1 EP 0104865 W EP0104865 W EP 0104865W WO 02087687 A1 WO02087687 A1 WO 02087687A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- micro
- area
- contact structure
- contacts
- structure according
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0526—Head electrodes
- A61N1/0543—Retinal electrodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0551—Spinal or peripheral nerve electrodes
Definitions
- the present invention relates to a micro-contact structure intended for implantation in a mammal, in particular in humans, which is provided for contacting nerve tissue in the visual system. More precisely, the micro-contact structure should be set up to contact the ganglion cells in the retina around the fovea on the one hand or to contact the visual cortex (Area VI).
- the first cause is the destruction of the photoreceptor layer in the retina, after which incident photons are not converted into appropriate stimulation of the ganglion cells.
- the ganglion cells are only partially affected, so that external stimulation of the ganglion cells still present can produce a visual perception.
- developments have been undertaken for some time that involve the implantation of a
- micro contact structure for contacting the ganglion cells.
- the second essential cause of blindness in the present context can be an interruption of the signal transmission between the ganglion cells and the area in the brain responsible for visual perception or a malfunction of the ganglion cells themselves. Implants are also being developed for this clinical picture, in which a micro-contact structure directly with the visual
- Cortex more precisely the area VI of the visual cortex, are in contact and generate a visual perception there by electrical stimulation.
- micro-contact structures known hitherto consist essentially of a carrier material which carries on one side electrically conductive, pin-shaped or needle-shaped contact elements which rise above the plane of the carrier film.
- Such microcontact structures are known for example from US 5,109,844, US 5,159,927, US 5,411,540, DE 19525570 AI or EP 0460320 B1.
- the individual contacts are uniform, that is to say distributed with a constant areal density on the surface of the implant.
- the areal density is approximately in the range of up to 20 contacts per mm 2 . So far it has been assumed that to increase the visual resolution, the highest possible surface density of the micro-contacts is desirable.
- each individual micro contact is fed by a separate channel of an encoder.
- the boundary conditions of this external device are the dimensions, the energy consumption and ultimately also the costs. If a given number of micro-contacts can be supplied with a given external supply unit, then this number of micro-contacts should be used to generate the best possible visual perception.
- the current distribution of the microcontacts with constant areal density is disadvantageous for this, because it does not take into account that an area of the central field of view for the
- Detection of certain objects is rated higher than the surrounding edge area.
- the tissue to be contacted with the microcontacts is not constructed in such a way that a certain distance between two points on the tissue in each area of the field of view corresponds to the same angular distance with respect to the viewing axis. It is rather the case that in the case of ganglion cells of the retina around the area of the sharpest vision, which is called fovea, there are no ganglion cells at all, then there is a large density of ganglion cells at a small radial distance from the center of the fovea, which is too one crater-like bulge at the edge of the fovea. Following this area, the layer of ganglion cells becomes thinner.
- the micro contacts in the center of the fovea do not reach ganglion cells.
- the channels of the external supply device connected to these microcontacts remain without physiological function.
- In the area of the "crater rim" of the fovea there are very many ganglion cells per unit area, so that for a given number of ganglion cells there are relatively few micro-contacts available. Outside, the areal density of the ganglion cells then decreases, while the areal density of
- Microcontact remains the same. The number of microcontacts available for a certain number of ganglion cells is increasing.
- This task is solved for the implantation in the eye by a micro-contact structure with the features of claim 1 and for the implantation on the visual cortex by a micro-contact structure with the features of claim 7.
- the distribution of the microcontacts can be chosen so that the available channels, which are limited by the external resources, are allocated to the one to be mapped as efficiently as possible Field of view. Received in the process Areas of the visual field with a higher physiological rating have a higher microcontact density than areas with less relevance.
- the areal density of the microcontacts can be adapted to the density of the neurons to be contacted in the tissue contacted in each case.
- Micro-contact structure for epiretinal contacting a round or oval rotationally symmetrical configuration with a center point is selected, the center point being arranged in the implanted state in the area of the fovea of the eye and an area with a radius of approximately 175 to 200 ⁇ m around this center point free of micro contacts, at least of actively used micro contacts.
- the microcontacts are preferably arranged with their largest available surface density in a region that is spaced radially from the center by about 200 ⁇ m to 1200 ⁇ m. In a region that is spaced radially from the center point by more than approximately 1200 ⁇ m and is rated physiologically less, the microcontacts preferably have a lower surface density than in the first region, so that fewer resources of the external supply device are required for this region.
- micro-contacts are preferably arranged essentially rotationally symmetrically around the center of the micro-contact structure.
- the distribution of the micro-contacts in the first area and in the second area becomes advantageous varies continuously, with a surface density maximum in the first region and from there the surface density continuously decreases radially outwards. Given the limited number of micro-contacts (a few 100 per implant), one can also speak of a quasi-continuous distribution.
- a further optimization between the physiological benefit of the visual perception generated by the micro-contact structure and the number of available micro-contacts or the resources associated with the micro-contacts is achieved if the surface density of the micro-contacts is greater in the plane that represents the horizontal in the natural visual field than in the areas that are up and down in the natural field of vision.
- the microcontacts are preferably arranged in an approximately parabolic area in accordance with the retinotopic projection of the visual field on the visual cortex, more precisely on the area VI per half of the visual field, the areal density of the microcontacts having a maximum in the area of the apex of the parabola.
- the parabolic area preferably corresponds to the shape of the visual cortex, the greatest density of the microcontacts being in an area which corresponds to the fovea.
- About 90% of the microcontacts are preferably arranged in the area which corresponds to an approximately concentric field of view with an opening angle of 5 ° from the viewing axis.
- the areal density of the microcontacts preferably decreases continuously or quasi-continuously in each direction.
- a particularly good utilization of the resources is achieved if the areal density in the direction depicting the horizontal plane of the natural visual field is higher than in the areas which represent the top and bottom of the natural visual field.
- the areal density of the microcontacts decreases in a temporal and further eccentric direction.
- a micro contact structure with an approximately rotationally symmetrical arrangement for the epiretinal implantation in a plan view;
- micro-contact structure with an approximately parabolic arrangement for the cortical implantation, likewise in a top view; such as
- Fig. 4 a graphical representation of the course of the
- FIG. 1 shows a micro-contact structure with an approximately rotationally symmetrical arrangement for epiretinal implantation in one eye in a top view.
- the micro-contact structure has an approximately circular disk-shaped carrier film 1, which is divided into several sectors, for example, and is made of polyimide. A multiplicity (approximately 200 in FIG. 1) of microcontacts 2 is formed on this carrier film, which micro-contacts 2 consist, for example, of small, protruding platinum structures which are approximately perpendicular to the carrier film. These micro-contacts 2 are in turn connected via conductor tracks to a data line 3 leading to the outside, which unidirectionally or bidirectionally conducts signals to the micro-contacts 2 or receives them. Instead of a data line, wireless communication can also be provided.
- the carrier film 1 has a total of three concentric regions, a central region 5, which covers the fovea in the implanted state, a first region 6, which covers the crater-shaped edge of the fovea in the implanted state, and an outer region 7, which extends radially further out lying areas of the retina.
- the area 5 can also be free of material in a specific exemplary embodiment, that is to say form a central hole in the implant. This area 5 has no function for the implant in the present context.
- the first area 6 contacts the "crater rim", ie the area immediately surrounding the fovea, in which the density of the ganglion cells is greatest.
- the area of the ganglion cells that corresponds to the central foveal and parafoveal visual field.
- the micro contacts 2 with the greatest area density are arranged in this area 6.
- the area 6 contains approximately 180 of the approximately 200 microcontacts in FIG. 1. It represents a field of view up to an eccentricity of approximately 8 ° (conical with an opening angle of 16 °).
- the area 6 will not be flat, but will be adapted to the outer contour of the foveal area of the retina and, if necessary, will be divided into sectors.
- the central region 5 is free of micro-contacts and consequently has an areal density of 0.
- the first area 6 has a maximum at 10, which corresponds as closely as possible to the area of the highest ganglion cell density of the retina.
- the second outer area 7 has a decreasing surface density, which also reflects the less physiologically significant significance of the assigned outer visual field.
- the first area 6, with its higher resolution should enable the implant carrier to recognize an object, while the second area, with its lower resolution, should in particular enable movement to be perceived.
- FIG. 3 shows a top view of a cortical implant 11 with micro contacts 12 which are on the Surface as in the embodiment of FIG. 1 are arranged perpendicular to the plane of the carrier film.
- a unidirectional or bidirectional data line 13 establishes the connection to an external resource.
- the shape of the implant corresponds to the shape of the right visual cortex in the brain of a rhesus monkey, in which the visual field is mapped onto a parabolic area.
- This retinotopic mapping of the visual field to Area VI of the visual cortex is known from the literature and has been experimentally proven, see Tootell et al., J. Neur. 1988 vol. 8 pp. 1531 - 1568.
- the visual field of other mammals is also mapped onto the respective visual cortex, the shape of which can vary.
- a second mirror-image implant is provided, which contacts the opposite left visual cortex. Both halves of the visual field are then accessible.
- the areal density of the microcontacts is illustrated in FIG. 4 in a representation corresponding to FIG. 2.
- the areal density decreases continuously, an area extending from point F' to approximately line 15 having a field of view up to an eccentricity of 5 ° for the associated left half of the field of view.
- This area contains around 80% of the available micro contacts 12.
- this configuration means that, as described above, the central region up to an eccentricity of, for example, 5 ° allows objects to be recognized, while the region of greater eccentricity lying outside this cone only allows a perception which may cause the implant carrier to be the peripherally perceived object to be able to recognize it.
- micro contacts themselves can be pointed in areas with a high surface density or with a particularly small diameter, while in the Outside areas with a low surface density of micro contacts, these can have a blunt design, for example hemispherical.
- the assigned receptive fields are stimulated very selectively, while in the outside area larger receptive fields are reached with a few micro contacts.
- Embodiments may also be micro-contacts with a uniform areal density if the number of micro-contacts actively connected to the external resource varies. A greater number of microcontacts will then be physically present in the peripheral area, but will not be contacted, while in the area of the central field of view every or almost every microcontact is active.
Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01938141A EP1383574B1 (de) | 2001-04-28 | 2001-04-30 | Mikrokontaktstruktur zur implantation bei einem säugetier, insbesondere bei einem menschen |
DE50110515T DE50110515D1 (de) | 2001-04-28 | 2001-04-30 | Mikrokontaktstruktur zur implantation bei einem säugetier, insbesondere bei einem menschen |
US10/476,239 US7177697B2 (en) | 2001-04-28 | 2001-04-30 | Microcontact structure for implantation in a mammal, especially a human being |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10120908A DE10120908A1 (de) | 2001-04-28 | 2001-04-28 | Mikrokontaktstruktur zur Implantation bei einem Säugetier, insbesondere bei einem Menschen |
DE10120908.8 | 2001-04-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2002087687A1 true WO2002087687A1 (de) | 2002-11-07 |
Family
ID=7683085
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2001/004865 WO2002087687A1 (de) | 2001-04-28 | 2001-04-30 | Mikrokontaktstruktur zur implantation bei einem säugetier, insbesondere bei einem menschen |
Country Status (7)
Country | Link |
---|---|
US (1) | US7177697B2 (de) |
EP (3) | EP1383574B1 (de) |
AT (3) | ATE556740T1 (de) |
DE (3) | DE10120908A1 (de) |
ES (3) | ES2269411T3 (de) |
TW (1) | TW520987B (de) |
WO (1) | WO2002087687A1 (de) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7149586B2 (en) * | 2002-03-28 | 2006-12-12 | Second Sight Medical Products, Inc. | Variable pitch electrode array |
US8190266B2 (en) * | 2006-02-15 | 2012-05-29 | Dohey Eye Institute | Wide-field retinal prosthesis |
US8197539B2 (en) * | 2006-05-05 | 2012-06-12 | University Of Southern California | Intraocular camera for retinal prostheses |
US8718784B2 (en) * | 2010-01-14 | 2014-05-06 | Nano-Retina, Inc. | Penetrating electrodes for retinal stimulation |
US8442641B2 (en) | 2010-08-06 | 2013-05-14 | Nano-Retina, Inc. | Retinal prosthesis techniques |
US8150526B2 (en) | 2009-02-09 | 2012-04-03 | Nano-Retina, Inc. | Retinal prosthesis |
US8706243B2 (en) | 2009-02-09 | 2014-04-22 | Rainbow Medical Ltd. | Retinal prosthesis techniques |
US8428740B2 (en) | 2010-08-06 | 2013-04-23 | Nano-Retina, Inc. | Retinal prosthesis techniques |
US8588921B2 (en) | 2010-11-12 | 2013-11-19 | Second Sight Medical Products, Inc. | Visual prosthesis with an improved electrode array adapted for foveal stimulation |
US8571669B2 (en) | 2011-02-24 | 2013-10-29 | Nano-Retina, Inc. | Retinal prosthesis with efficient processing circuits |
US9370417B2 (en) | 2013-03-14 | 2016-06-21 | Nano-Retina, Inc. | Foveated retinal prosthesis |
US9474902B2 (en) | 2013-12-31 | 2016-10-25 | Nano Retina Ltd. | Wearable apparatus for delivery of power to a retinal prosthesis |
US9331791B2 (en) | 2014-01-21 | 2016-05-03 | Nano Retina Ltd. | Transfer of power and data |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0460320A2 (de) | 1989-08-08 | 1991-12-11 | Alan Y. Chow | Künstliche Netzhaut |
US5109844A (en) | 1990-10-11 | 1992-05-05 | Duke University | Retinal microstimulation |
US5159927A (en) | 1989-07-26 | 1992-11-03 | Ferdinand Schmid | Visual prosthesis apparatus and method |
US5411540A (en) | 1993-06-03 | 1995-05-02 | Massachusetts Institute Of Technology | Method and apparatus for preferential neuron stimulation |
DE19525570A1 (de) | 1994-07-13 | 1996-01-18 | Fraunhofer Ges Forschung | Flexible künstliche Nervenplatte |
WO1996039221A1 (en) * | 1995-06-06 | 1996-12-12 | Vincent Chow | Multi-phasic microphotodiode retinal implant and adaptive imaging retinal stimulation system |
DE19705987A1 (de) * | 1996-10-23 | 1998-05-14 | Univ Eberhard Karls | Optisch ansteuerbare Mikroelektrodenanordnung zum Stimulieren von Zellen, insbesondere Retina-Implantat |
US5873901A (en) * | 1995-06-30 | 1999-02-23 | Space Vacuum Epitaxy Center University Of Houston | Treating retinal damage by implanting thin film optical detectors |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4628933A (en) * | 1985-07-23 | 1986-12-16 | Michelson Robin P | Method and apparatus for visual prosthesis |
US5215088A (en) * | 1989-11-07 | 1993-06-01 | The University Of Utah | Three-dimensional electrode device |
DE19707046A1 (de) * | 1997-02-21 | 1998-08-27 | Rolf Prof Dr Ing Eckmiller | Lernfähiger "Active Vision" Implant Encoder |
US5935155A (en) * | 1998-03-13 | 1999-08-10 | John Hopkins University, School Of Medicine | Visual prosthesis and method of using same |
US6324429B1 (en) * | 1998-05-08 | 2001-11-27 | Massachusetts Eye And Ear Infirmary | Chronically implantable retinal prosthesis |
DE10020846A1 (de) * | 2000-04-28 | 2001-12-06 | Intelligent Implants Gmbh | Mikrokontaktstruktur für Neuroprothesen zur Implantation an Nervengewebe und Verfahren hierzu |
-
2001
- 2001-04-28 DE DE10120908A patent/DE10120908A1/de not_active Withdrawn
- 2001-04-30 EP EP01938141A patent/EP1383574B1/de not_active Expired - Lifetime
- 2001-04-30 AT AT10008956T patent/ATE556740T1/de active
- 2001-04-30 AT AT01938141T patent/ATE333301T1/de active
- 2001-04-30 ES ES01938141T patent/ES2269411T3/es not_active Expired - Lifetime
- 2001-04-30 DE DE50110515T patent/DE50110515D1/de not_active Expired - Lifetime
- 2001-04-30 US US10/476,239 patent/US7177697B2/en not_active Expired - Fee Related
- 2001-04-30 DE DE50115683T patent/DE50115683D1/de not_active Expired - Lifetime
- 2001-04-30 AT AT06012895T patent/ATE485861T1/de active
- 2001-04-30 ES ES10008956T patent/ES2387738T3/es not_active Expired - Lifetime
- 2001-04-30 EP EP06012895A patent/EP1712253B1/de not_active Expired - Lifetime
- 2001-04-30 WO PCT/EP2001/004865 patent/WO2002087687A1/de active IP Right Grant
- 2001-04-30 EP EP10008956A patent/EP2263740B1/de not_active Expired - Lifetime
- 2001-04-30 ES ES06012895T patent/ES2355253T3/es not_active Expired - Lifetime
- 2001-11-22 TW TW090128977A patent/TW520987B/zh not_active IP Right Cessation
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5159927A (en) | 1989-07-26 | 1992-11-03 | Ferdinand Schmid | Visual prosthesis apparatus and method |
EP0460320A2 (de) | 1989-08-08 | 1991-12-11 | Alan Y. Chow | Künstliche Netzhaut |
US5109844A (en) | 1990-10-11 | 1992-05-05 | Duke University | Retinal microstimulation |
US5411540A (en) | 1993-06-03 | 1995-05-02 | Massachusetts Institute Of Technology | Method and apparatus for preferential neuron stimulation |
DE19525570A1 (de) | 1994-07-13 | 1996-01-18 | Fraunhofer Ges Forschung | Flexible künstliche Nervenplatte |
WO1996039221A1 (en) * | 1995-06-06 | 1996-12-12 | Vincent Chow | Multi-phasic microphotodiode retinal implant and adaptive imaging retinal stimulation system |
US5873901A (en) * | 1995-06-30 | 1999-02-23 | Space Vacuum Epitaxy Center University Of Houston | Treating retinal damage by implanting thin film optical detectors |
DE19705987A1 (de) * | 1996-10-23 | 1998-05-14 | Univ Eberhard Karls | Optisch ansteuerbare Mikroelektrodenanordnung zum Stimulieren von Zellen, insbesondere Retina-Implantat |
Also Published As
Publication number | Publication date |
---|---|
EP1712253B1 (de) | 2010-10-27 |
EP2263740A3 (de) | 2011-03-16 |
EP1712253A3 (de) | 2009-01-14 |
TW520987B (en) | 2003-02-21 |
ATE485861T1 (de) | 2010-11-15 |
ATE333301T1 (de) | 2006-08-15 |
ES2387738T3 (es) | 2012-10-01 |
US7177697B2 (en) | 2007-02-13 |
EP1383574B1 (de) | 2006-07-19 |
ES2269411T3 (es) | 2007-04-01 |
EP2263740A2 (de) | 2010-12-22 |
EP1712253A2 (de) | 2006-10-18 |
DE50115683D1 (de) | 2010-12-09 |
DE10120908A1 (de) | 2002-10-31 |
DE50110515D1 (de) | 2006-08-31 |
ES2355253T3 (es) | 2011-03-24 |
US20040172099A1 (en) | 2004-09-02 |
EP2263740B1 (de) | 2012-05-09 |
ATE556740T1 (de) | 2012-05-15 |
EP1383574A1 (de) | 2004-01-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP1448264B1 (de) | Retina-implantat mit elektrodenanordnung zur elektrischen stimulation von biologischem material | |
EP0951312B1 (de) | Optisch ansteuerbare mikroelektrodenanordnung zum stimulieren von zellen, insbesondere retina-implantat | |
EP2699311B1 (de) | Vorrichtung zur aufbringung eines transkutanen elektrischen stimulationsreizes auf die oberfläche eines abschnitts des menschlichen ohrs | |
EP1712253B1 (de) | Mikrokontaktstruktur zur Implantation bei einem Säugetier, insbesondere bei einem Menschen | |
DE19705988C2 (de) | Retina-Implantat | |
DE102006037546A1 (de) | Vorrichtung zur Unterstützung der Regeneration der Sehkraft und/oder des Sehvermögens | |
EP3784327B1 (de) | Elektrodenkörper einer elektrodenanordnung und elektrodenanordnung zur elektrischen stimulation sowie verfahren zur herstellung einer elektrodenanordnung | |
DE202012012950U1 (de) | Sonde für Brainmapping | |
EP1587578B1 (de) | Retina-implantat zum stimulieren einer retina in abhängigkeit von einfallendem licht | |
EP1349608A1 (de) | Siebelektrode zur anbindung an einen nervenstumpf | |
DE102007019842A1 (de) | Verfahren und Anordnung zum elektrischen Kontaktieren eines membranumhüllten Objekts mit einer Elektrode | |
DE112018000005T5 (de) | Linsenstruktur und Fahrzeuglampensystem | |
WO2005087309A1 (de) | Stimulationselektrode | |
WO2008022366A1 (de) | Mehrkanalelektrode für cochlea-implantate mit einer mehrzahl von über die länge der elektrode verteilten kontakten | |
DE4424753B4 (de) | Retina-Implantat | |
DE102007038160B4 (de) | Vorrichtung zur Stimulation des Riechepithels | |
DE10028522A1 (de) | Biodegradable Neuroelektrode | |
DE19705987C2 (de) | Optisch ansteuerbare Mikroelektrodenanordnung zum Stimulieren von Zellen, insbesondere Retina-Implantat | |
EP1790379B1 (de) | Retina Implantat zur elektrischen Stimulation der Netzhaut | |
EP3884546B1 (de) | Implantierbare elektrische verbindungseinrichtung | |
Lenarz | Funktionsersatz des Innenohres | |
WO2021219614A1 (de) | Hörprothese, insbesondere cochlea-implantat | |
DE10102183A1 (de) | Siebelektrode zur Anbindung an einen Nervenstumpf |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
WWE | Wipo information: entry into national phase |
Ref document number: 2001938141 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 10476239 Country of ref document: US |
|
WWP | Wipo information: published in national office |
Ref document number: 2001938141 Country of ref document: EP |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
NENP | Non-entry into the national phase |
Ref country code: JP |
|
WWG | Wipo information: grant in national office |
Ref document number: 2001938141 Country of ref document: EP |