WO2002088738A3 - Device and method for the assay of a specific particle in a liquid sample - Google Patents

Device and method for the assay of a specific particle in a liquid sample Download PDF

Info

Publication number
WO2002088738A3
WO2002088738A3 PCT/NL2002/000172 NL0200172W WO02088738A3 WO 2002088738 A3 WO2002088738 A3 WO 2002088738A3 NL 0200172 W NL0200172 W NL 0200172W WO 02088738 A3 WO02088738 A3 WO 02088738A3
Authority
WO
WIPO (PCT)
Prior art keywords
specific type
particles
liquid sample
binding
hydraulic network
Prior art date
Application number
PCT/NL2002/000172
Other languages
French (fr)
Other versions
WO2002088738A2 (en
Inventor
Richard Bernardus M Schasfoort
Original Assignee
Ibis Technologies B V
Richard Bernardus M Schasfoort
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ibis Technologies B V, Richard Bernardus M Schasfoort filed Critical Ibis Technologies B V
Priority to AU2002239166A priority Critical patent/AU2002239166A1/en
Publication of WO2002088738A2 publication Critical patent/WO2002088738A2/en
Publication of WO2002088738A3 publication Critical patent/WO2002088738A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G01N33/587—Nanoparticles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings

Abstract

A device and method for the assay of at least one specific type of particle in a liquid sample. The device comprising: - a hydraulic network comprising at least one capillary duct and at least one fluid reservoir; - at least two electrodes for the application of an electric potential difference for the purpose of generating an electro-osmotic flow in at least a part of the hydraulic network; - at least one binding surface connected to the hydraulic network along which surface a liquid can flow, the surface being suitable to be provided with binding sites where a selective bonding can take place with particles of the specific type, and - a detection system for the assaying of the particles of the specific type. The method comprising the following steps: A. the application of a number of binding sites onto the binding surface; B. conducting of at least a part of the liquid sample to the binding surface by generating an electro-osmotic flow in at least a part of the hydraulic network by the application of electric potential differences by means of electrodes, whereby a bonding takes place between particles of the specific type and at least a part of the binding sites applied on the binding surface, and C. assaying the particles of the specific type by means of a detection system.
PCT/NL2002/000172 2001-03-16 2002-03-13 Device and method for the assay of a specific particle in a liquid sample WO2002088738A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002239166A AU2002239166A1 (en) 2001-03-16 2002-03-13 Device and method for the assay of a specific particle in a liquid sample

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL1017625 2001-03-16
NL1017625A NL1017625C2 (en) 2001-03-16 2001-03-16 Device and method for determining at least one specific type of particle in a liquid sample.

Publications (2)

Publication Number Publication Date
WO2002088738A2 WO2002088738A2 (en) 2002-11-07
WO2002088738A3 true WO2002088738A3 (en) 2003-05-08

Family

ID=19773087

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/NL2002/000172 WO2002088738A2 (en) 2001-03-16 2002-03-13 Device and method for the assay of a specific particle in a liquid sample

Country Status (3)

Country Link
AU (1) AU2002239166A1 (en)
NL (1) NL1017625C2 (en)
WO (1) WO2002088738A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL1027633C2 (en) * 2004-12-01 2006-06-02 Stichting Tech Wetenschapp Determining several types of target particles in a sample comprises loading zones of a carrier with different types of first particles and contacting subzones with mixtures of second particles bound to third particles

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5194300A (en) * 1987-07-15 1993-03-16 Cheung Sau W Methods of making fluorescent microspheres
WO1996002837A1 (en) * 1994-07-20 1996-02-01 Sios, Inc. Apparatus and method for the detection and assay of organic molecules
EP0851230A1 (en) * 1996-12-30 1998-07-01 Diagnostic Products Corporation Method and Apparatus for Immunoassay using Fluorescent Induced Surface Plasma Emission

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5194300A (en) * 1987-07-15 1993-03-16 Cheung Sau W Methods of making fluorescent microspheres
WO1996002837A1 (en) * 1994-07-20 1996-02-01 Sios, Inc. Apparatus and method for the detection and assay of organic molecules
EP0851230A1 (en) * 1996-12-30 1998-07-01 Diagnostic Products Corporation Method and Apparatus for Immunoassay using Fluorescent Induced Surface Plasma Emission

Also Published As

Publication number Publication date
NL1017625C2 (en) 2002-09-24
AU2002239166A1 (en) 2002-11-11
WO2002088738A2 (en) 2002-11-07

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