WO2002095362A3 - Method and apparatus for feedback controlled electrospray - Google Patents

Method and apparatus for feedback controlled electrospray Download PDF

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Publication number
WO2002095362A3
WO2002095362A3 PCT/US2002/016559 US0216559W WO02095362A3 WO 2002095362 A3 WO2002095362 A3 WO 2002095362A3 US 0216559 W US0216559 W US 0216559W WO 02095362 A3 WO02095362 A3 WO 02095362A3
Authority
WO
WIPO (PCT)
Prior art keywords
mobile phase
capillary
nozzle
light
electrospray
Prior art date
Application number
PCT/US2002/016559
Other languages
French (fr)
Other versions
WO2002095362A2 (en
Inventor
Gary A Valaskovic
Mike S Lee
Original Assignee
New Objective Inc
Gary A Valaskovic
Mike S Lee
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by New Objective Inc, Gary A Valaskovic, Mike S Lee filed Critical New Objective Inc
Priority to CA002448387A priority Critical patent/CA2448387C/en
Priority to EP02744176A priority patent/EP1395939A4/en
Priority to AU2002339871A priority patent/AU2002339871A1/en
Priority to JP2002591790A priority patent/JP4080893B2/en
Priority to DE2002744176 priority patent/DE02744176T1/en
Publication of WO2002095362A2 publication Critical patent/WO2002095362A2/en
Publication of WO2002095362A3 publication Critical patent/WO2002095362A3/en

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Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/165—Electrospray ionisation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B12/00—Arrangements for controlling delivery; Arrangements for controlling the spray area
    • B05B12/08—Arrangements for controlling delivery; Arrangements for controlling the spray area responsive to condition of liquid or other fluent material to be discharged, of ambient medium or of target ; responsive to condition of spray devices or of supply means, e.g. pipes, pumps or their drive means
    • B05B12/082—Arrangements for controlling delivery; Arrangements for controlling the spray area responsive to condition of liquid or other fluent material to be discharged, of ambient medium or of target ; responsive to condition of spray devices or of supply means, e.g. pipes, pumps or their drive means responsive to a condition of the discharged jet or spray, e.g. to jet shape, spray pattern or droplet size

Abstract

A capillary nozzle (1) is provided with mobile phase by mobile phase pump (2), which pumps the mobile phase through the capillary to discharge from the nozzle at opening (I1) Electrical voltage is applied to capillary nozzle (1) by high voltage power supply (3) through electrode (4). A counter electrode (5), which is incorporated into to the inlet of a mass spectrometer is 'grounded', i.e., is at ground potential. The light source (7) illuminates electospray (6) with intense light, which is positioned and focused by lens (71) to optimize contrast and the scattering of light by the electrospray (6) droplets.
PCT/US2002/016559 2001-05-24 2002-05-24 Method and apparatus for feedback controlled electrospray WO2002095362A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA002448387A CA2448387C (en) 2001-05-24 2002-05-24 Method and apparatus for feedback controlled electrospray
EP02744176A EP1395939A4 (en) 2001-05-24 2002-05-24 Method and apparatus for feedback controlled electrospray
AU2002339871A AU2002339871A1 (en) 2001-05-24 2002-05-24 Method and apparatus for feedback controlled electrospray
JP2002591790A JP4080893B2 (en) 2001-05-24 2002-05-24 Method and apparatus for feedback control of electrospray
DE2002744176 DE02744176T1 (en) 2001-05-24 2002-05-24 METHOD AND DEVICE FOR ELECTROSPRAY WITH FEEDBACK CONTROL

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29334101P 2001-05-24 2001-05-24
US60/293,341 2001-05-24

Publications (2)

Publication Number Publication Date
WO2002095362A2 WO2002095362A2 (en) 2002-11-28
WO2002095362A3 true WO2002095362A3 (en) 2003-10-30

Family

ID=23128682

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/016559 WO2002095362A2 (en) 2001-05-24 2002-05-24 Method and apparatus for feedback controlled electrospray

Country Status (7)

Country Link
US (2) US6744046B2 (en)
EP (1) EP1395939A4 (en)
JP (1) JP4080893B2 (en)
AU (1) AU2002339871A1 (en)
CA (1) CA2448387C (en)
DE (1) DE02744176T1 (en)
WO (1) WO2002095362A2 (en)

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CA2448387C (en) 2008-02-05
US6977372B2 (en) 2005-12-20
EP1395939A2 (en) 2004-03-10
WO2002095362A2 (en) 2002-11-28
US20020190203A1 (en) 2002-12-19
US6744046B2 (en) 2004-06-01
CA2448387A1 (en) 2002-11-28
JP2004534354A (en) 2004-11-11
DE02744176T1 (en) 2005-01-13
JP4080893B2 (en) 2008-04-23
AU2002339871A1 (en) 2002-12-03
EP1395939A4 (en) 2006-06-07
US20040173743A1 (en) 2004-09-09

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