WO2002096415A3 - Use of azetidinone substituted derivatives in the treatment of alzheimer's disease - Google Patents

Use of azetidinone substituted derivatives in the treatment of alzheimer's disease Download PDF

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Publication number
WO2002096415A3
WO2002096415A3 PCT/US2002/016306 US0216306W WO02096415A3 WO 2002096415 A3 WO2002096415 A3 WO 2002096415A3 US 0216306 W US0216306 W US 0216306W WO 02096415 A3 WO02096415 A3 WO 02096415A3
Authority
WO
WIPO (PCT)
Prior art keywords
alzheimer
disease
treatment
substituted derivatives
azetidinone
Prior art date
Application number
PCT/US2002/016306
Other languages
French (fr)
Other versions
WO2002096415A2 (en
Inventor
Harry R Davis
Eric Mcfee Parker
Heek Margaret Van
Gwendolyn Tse Wong
Laura B Merkel
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Priority to MXPA03010843A priority Critical patent/MXPA03010843A/en
Priority to EP02774113A priority patent/EP1392287B8/en
Priority to JP2002592925A priority patent/JP2004532868A/en
Priority to AU2002308778A priority patent/AU2002308778A1/en
Priority to DE60216275T priority patent/DE60216275T2/en
Priority to DK02774113T priority patent/DK1392287T3/en
Priority to CA002447884A priority patent/CA2447884A1/en
Publication of WO2002096415A2 publication Critical patent/WO2002096415A2/en
Publication of WO2002096415A3 publication Critical patent/WO2002096415A3/en
Priority to CY20071100048T priority patent/CY1105922T1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

Methods of preventing, treating, or ameliorating symptoms of Alzheimer's Disease, regulating production or levels of amyloid β (Aβ) peptides and/or regulating the amount of ApoE isoform 4 in the bloodstream and/or brain are provided which include the step of administering to a subject in need of such treatment an effective amount of a composition including at least one compound represented by Formulae (I-X) disclosed herein.
PCT/US2002/016306 2001-05-25 2002-05-22 Use of azetidinone substituted derivatives in the treatment of alzheimer's disease WO2002096415A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
MXPA03010843A MXPA03010843A (en) 2001-05-25 2002-05-22 Use of azetidinone substituted derivatives in the treatment of alzheimer's disease.
EP02774113A EP1392287B8 (en) 2001-05-25 2002-05-22 Use of substituted azetidinone derivatives in the treatment of Alzheimer's disease
JP2002592925A JP2004532868A (en) 2001-05-25 2002-05-22 Use of azetidinone-substituted derivatives in the treatment of Alzheimer's disease
AU2002308778A AU2002308778A1 (en) 2001-05-25 2002-05-22 Use of azetidinone substituted derivatives in the treatment of alzheimer's disease
DE60216275T DE60216275T2 (en) 2001-05-25 2002-05-22 USE OF AZETIDINONE-SUBSTITUTED DERIVATIVES IN THE TREATMENT OF ALZHEIMER DISEASE
DK02774113T DK1392287T3 (en) 2001-05-25 2002-05-22 Use of substituted azetidinone derivatives in the treatment of Alzheimer's disease
CA002447884A CA2447884A1 (en) 2001-05-25 2002-05-22 Use of azetidinone substituted derivatives in the treatment of alzheimer's disease
CY20071100048T CY1105922T1 (en) 2001-05-25 2007-01-15 USE OF SUBSTITUTED AZETIDINONE DERIVATIVES IN THE TREATMENT OF ALZHEIMER'S DISEASE

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US29365101P 2001-05-25 2001-05-25
US60/293,651 2001-05-25
US32391101P 2001-09-21 2001-09-21
US60/323,911 2001-09-21

Publications (2)

Publication Number Publication Date
WO2002096415A2 WO2002096415A2 (en) 2002-12-05
WO2002096415A3 true WO2002096415A3 (en) 2003-01-16

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/016306 WO2002096415A2 (en) 2001-05-25 2002-05-22 Use of azetidinone substituted derivatives in the treatment of alzheimer's disease

Country Status (14)

Country Link
US (1) US20030013699A1 (en)
EP (1) EP1392287B8 (en)
JP (1) JP2004532868A (en)
AR (1) AR038956A1 (en)
AT (1) ATE345792T1 (en)
AU (1) AU2002308778A1 (en)
CA (1) CA2447884A1 (en)
CY (1) CY1105922T1 (en)
DE (1) DE60216275T2 (en)
DK (1) DK1392287T3 (en)
ES (1) ES2275007T3 (en)
MX (1) MXPA03010843A (en)
PT (1) PT1392287E (en)
WO (1) WO2002096415A2 (en)

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Also Published As

Publication number Publication date
EP1392287B1 (en) 2006-11-22
WO2002096415A2 (en) 2002-12-05
EP1392287B8 (en) 2007-01-10
US20030013699A1 (en) 2003-01-16
ES2275007T3 (en) 2007-06-01
EP1392287A2 (en) 2004-03-03
AR038956A1 (en) 2005-02-02
DE60216275T2 (en) 2007-06-21
DE60216275D1 (en) 2007-01-04
ATE345792T1 (en) 2006-12-15
AU2002308778A1 (en) 2002-12-09
JP2004532868A (en) 2004-10-28
MXPA03010843A (en) 2004-02-17
CA2447884A1 (en) 2002-12-05
CY1105922T1 (en) 2011-04-06
DK1392287T3 (en) 2007-03-19
PT1392287E (en) 2007-02-28

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