WO2002097409A1 - Verfahren zur automatisierten erkennung, spektroskopischen analyse und identifizierung von partikeln - Google Patents

Verfahren zur automatisierten erkennung, spektroskopischen analyse und identifizierung von partikeln Download PDF

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Publication number
WO2002097409A1
WO2002097409A1 PCT/EP2002/005779 EP0205779W WO02097409A1 WO 2002097409 A1 WO2002097409 A1 WO 2002097409A1 EP 0205779 W EP0205779 W EP 0205779W WO 02097409 A1 WO02097409 A1 WO 02097409A1
Authority
WO
WIPO (PCT)
Prior art keywords
particle
scattered light
particles
identification
analysis
Prior art date
Application number
PCT/EP2002/005779
Other languages
German (de)
English (en)
French (fr)
Inventor
Heiko Leonhardt
Ludwig Pohlmann
Lothar Holz
Markus Lankers
Original Assignee
Rap.Id Particle Systems Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rap.Id Particle Systems Gmbh filed Critical Rap.Id Particle Systems Gmbh
Priority to DE10292357T priority Critical patent/DE10292357D2/de
Publication of WO2002097409A1 publication Critical patent/WO2002097409A1/de

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65Raman scattering
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/02Investigating particle size or size distribution
    • G01N15/0205Investigating particle size or size distribution by optical means, e.g. by light scattering, diffraction, holography or imaging
    • G01N15/0211Investigating a scatter or diffraction pattern
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84Systems specially adapted for particular applications
    • G01N21/88Investigating the presence of flaws or contamination
    • G01N21/94Investigating contamination, e.g. dust
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28Investigating the spectrum
    • G01J3/44Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
    • G01J3/4412Scattering spectrometry
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Electro-optical investigation, e.g. flow cytometers
    • G01N15/1468Electro-optical investigation, e.g. flow cytometers with spatial resolution of the texture or inner structure of the particle
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Electro-optical investigation, e.g. flow cytometers
    • G01N15/1434Electro-optical investigation, e.g. flow cytometers using an analyser being characterised by its optical arrangement
    • G01N2015/1452Adjustment of focus; Alignment
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • G01N21/6456Spatial resolved fluorescence measurements; Imaging
    • G01N2021/646Detecting fluorescent inhomogeneities at a position, e.g. for detecting defects
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65Raman scattering
    • G01N2021/653Coherent methods [CARS]
    • G01N2021/656Raman microprobe
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • G01N21/6456Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458Fluorescence microscopy
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84Systems specially adapted for particular applications
    • G01N21/88Investigating the presence of flaws or contamination
    • G01N21/8806Specially adapted optical and illumination features
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00Features of devices classified in G01N21/00
    • G01N2201/10Scanning
    • G01N2201/103Scanning by mechanical motion of stage
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00Features of devices classified in G01N21/00
    • G01N2201/10Scanning
    • G01N2201/108Miscellaneous
    • G01N2201/1087Focussed scan beam, e.g. laser

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Dispersion Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
PCT/EP2002/005779 2001-05-31 2002-05-24 Verfahren zur automatisierten erkennung, spektroskopischen analyse und identifizierung von partikeln WO2002097409A1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE10292357T DE10292357D2 (de) 2001-05-31 2002-05-24 Verfahren zur automatisierten Erkennung, spektroskopischen Analyse und Identifizierung von Partikeln

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10127538 2001-05-31
DE10127538.2 2001-05-31

Publications (1)

Publication Number Publication Date
WO2002097409A1 true WO2002097409A1 (de) 2002-12-05

Family

ID=7687430

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/005779 WO2002097409A1 (de) 2001-05-31 2002-05-24 Verfahren zur automatisierten erkennung, spektroskopischen analyse und identifizierung von partikeln

Country Status (2)

Country Link
DE (1) DE10292357D2 (es)
WO (1) WO2002097409A1 (es)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004008762A1 (de) * 2004-02-23 2005-09-08 Erwin Kayser-Threde Gmbh Verfahren und Vorrichtung zur Detektion und zum Identifizieren von Biopartikeln
WO2008020343A2 (en) * 2006-08-18 2008-02-21 Primus Special Projects (Pty) Ltd A sorter
NL1039263C2 (nl) * 2011-12-23 2013-06-26 Zevenaar Elektronica & Sensoren B V Apparaat en werkwijze voor het tellen en bemeten van deeltjes.
EP1904826B1 (en) * 2005-07-14 2019-02-20 Battelle Memorial Institute Systems and methods for biological and chemical detection
CN110346042A (zh) * 2019-08-01 2019-10-18 南京邮电大学 一种多传感器杂散光消除光谱仪

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0056426A2 (de) * 1980-10-08 1982-07-28 Firma Carl Zeiss Vorrichtung zur Darstellung von Probenparametern
US4766324A (en) * 1987-08-07 1988-08-23 Tencor Instruments Particle detection method including comparison between sequential scans
DE4111903A1 (de) * 1991-04-12 1992-10-15 Bayer Ag Spektroskopiekorrelierte licht-rastermikroskopie
EP0685731A1 (en) * 1994-06-02 1995-12-06 Mitsubishi Denki Kabushiki Kaisha Positioning method and analysis method of fine foreign matter and analyzer used therefor
DE19946110C1 (de) * 1999-09-17 2001-02-01 Apsys Advanced Particle System Optisches Verfahren zur Charakterisierung von Partikeln in einem System, z.B. einem Reinraum, und Vorrichtung zur Durchführung des Verfahrens

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0056426A2 (de) * 1980-10-08 1982-07-28 Firma Carl Zeiss Vorrichtung zur Darstellung von Probenparametern
US4766324A (en) * 1987-08-07 1988-08-23 Tencor Instruments Particle detection method including comparison between sequential scans
DE4111903A1 (de) * 1991-04-12 1992-10-15 Bayer Ag Spektroskopiekorrelierte licht-rastermikroskopie
EP0685731A1 (en) * 1994-06-02 1995-12-06 Mitsubishi Denki Kabushiki Kaisha Positioning method and analysis method of fine foreign matter and analyzer used therefor
DE19946110C1 (de) * 1999-09-17 2001-02-01 Apsys Advanced Particle System Optisches Verfahren zur Charakterisierung von Partikeln in einem System, z.B. einem Reinraum, und Vorrichtung zur Durchführung des Verfahrens

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004008762A1 (de) * 2004-02-23 2005-09-08 Erwin Kayser-Threde Gmbh Verfahren und Vorrichtung zur Detektion und zum Identifizieren von Biopartikeln
DE102004008762B4 (de) * 2004-02-23 2006-10-12 Erwin Kayser-Threde Gmbh Verfahren und Vorrichtung zur Detektion und zum Identifizieren von Biopartikeln
EP1904826B1 (en) * 2005-07-14 2019-02-20 Battelle Memorial Institute Systems and methods for biological and chemical detection
WO2008020343A2 (en) * 2006-08-18 2008-02-21 Primus Special Projects (Pty) Ltd A sorter
WO2008020343A3 (en) * 2006-08-18 2008-04-24 Primus Special Projects Pty Lt A sorter
NL1039263C2 (nl) * 2011-12-23 2013-06-26 Zevenaar Elektronica & Sensoren B V Apparaat en werkwijze voor het tellen en bemeten van deeltjes.
CN110346042A (zh) * 2019-08-01 2019-10-18 南京邮电大学 一种多传感器杂散光消除光谱仪
CN110346042B (zh) * 2019-08-01 2022-03-08 南京邮电大学 一种多传感器杂散光消除光谱仪

Also Published As

Publication number Publication date
DE10292357D2 (de) 2004-07-01

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